locus-tag	class	description
A9I65_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A9I65_RS00010	COG0592	DNA-directed DNA polymerase activity
A9I65_RS00015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A9I65_RS00015	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A9I65_RS00020	COG2501	S4 domain
A9I65_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A9I65_RS00030	COG0187	DNA topoisomerase II activity
A9I65_RS00040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A9I65_RS00045	COG2986	histidine ammonia-lyase
A9I65_RS00055	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A9I65_RS00065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A9I65_RS00070	COG4241	membrane
A9I65_RS00075	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
A9I65_RS00080	COG0359	binds to the 23S rRNA
A9I65_RS00085	COG0305	Participates in initiation and elongation during chromosome replication
A9I65_RS00090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A9I65_RS00095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A9I65_RS00115	COG0745	RESPONSE REGULATOR receiver
A9I65_RS00120	COG5002	protein histidine kinase activity
A9I65_RS00125	COG4863	YycH protein
A9I65_RS00135	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A9I65_RS00165	COG0584	glycerophosphoryl diester phosphodiesterase
A9I65_RS00170	COG2030	dehydratase
A9I65_RS00190	COG1846	Transcriptional regulator
A9I65_RS00190	COG1940	carbohydrate kinase activity
A9I65_RS00210	COG1937	Protein conserved in bacteria
A9I65_RS00215	COG2003	Belongs to the UPF0758 family
A9I65_RS00290	COG0514	ATP-dependent DNA helicase (RecQ)
A9I65_RS00295	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
A9I65_RS00305	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A9I65_RS00345	COG0531	amino acid
A9I65_RS00350	COG2217	Heavy metal translocating P-type atpase
A9I65_RS00365	COG3655	Transcriptional regulator
A9I65_RS00380	COG2188	Transcriptional regulator
A9I65_RS00385	COG2723	6-phospho-beta-galactosidase activity
A9I65_RS00395	COG0415	Belongs to the DNA photolyase family
A9I65_RS00410	COG0702	epimerase
A9I65_RS00415	COG2130	NADP-dependent
A9I65_RS00425	COG3177	Filamentation induced by cAMP protein fic
A9I65_RS00430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A9I65_RS00445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A9I65_RS00465	COG2235	arginine
A9I65_RS00480	COG2197	response regulator
A9I65_RS00485	COG4585	Histidine kinase
A9I65_RS00485	COG2203	Gaf domain
A9I65_RS00490	COG0842	Transport permease protein
A9I65_RS00535	COG1609	Transcriptional regulator
A9I65_RS00545	COG0673	inositol 2-dehydrogenase activity
A9I65_RS00555	COG0366	Alpha amylase catalytic
A9I65_RS00565	COG3833	ABC-type maltose transport systems, permease component
A9I65_RS00570	COG1175	transmembrane transport
A9I65_RS00580	COG3842	ATPase activity
A9I65_RS00585	COG0475	glutathione-regulated potassium exporter activity
A9I65_RS00590	COG0490	domain, Protein
A9I65_RS00600	COG0346	lactoylglutathione lyase activity
A9I65_RS00630	COG1131	(ABC) transporter
A9I65_RS00640	COG0366	Alpha amylase catalytic
A9I65_RS00645	COG2188	Transcriptional regulator
A9I65_RS00650	COG2222	sugar isomerase
A9I65_RS00655	COG1105	Belongs to the carbohydrate kinase PfkB family
A9I65_RS00670	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A9I65_RS00670	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A9I65_RS00675	COG3715	PTS system
A9I65_RS00680	COG3716	PTS system mannose fructose sorbose family IID component
A9I65_RS00690	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A9I65_RS00710	COG3314	Sporulation integral membrane protein YlbJ
A9I65_RS00745	COG1620	l-lactate permease
A9I65_RS00750	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A9I65_RS00755	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A9I65_RS00760	COG0156	8-amino-7-oxononanoate synthase activity
A9I65_RS00805	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A9I65_RS00820	COG0076	glutamate decarboxylase activity
A9I65_RS00835	COG2318	DinB family
A9I65_RS00840	COG0753	catalase activity
A9I65_RS00850	COG0783	Belongs to the Dps family
A9I65_RS00860	COG0436	Aminotransferase
A9I65_RS00885	COG1136	(ABC) transporter
A9I65_RS00895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A9I65_RS00915	COG1755	Isoprenylcysteine carboxyl methyltransferase
A9I65_RS00940	COG0579	oxidoreductase
A9I65_RS00975	COG1073	alpha beta
A9I65_RS00995	COG0438	transferase activity, transferring glycosyl groups
A9I65_RS01000	COG0183	Belongs to the thiolase family
A9I65_RS01015	COG0318	PFAM AMP-dependent synthetase and ligase
A9I65_RS01025	COG2814	Major facilitator Superfamily
A9I65_RS01035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A9I65_RS01045	COG1116	anion transmembrane transporter activity
A9I65_RS01065	COG1609	Transcriptional regulator
A9I65_RS01070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A9I65_RS01075	COG1869	D-ribose catabolic process
A9I65_RS01090	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A9I65_RS01130	COG3711	transcriptional antiterminator
A9I65_RS01135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A9I65_RS01145	COG3037	sugar-specific permease SgaT UlaA
A9I65_RS01150	COG1328	CTP reductase activity
A9I65_RS01175	COG1942	4-Oxalocrotonate Tautomerase
A9I65_RS01185	COG3443	Belongs to the bacterial solute-binding protein 9 family
A9I65_RS01185	COG0803	Belongs to the bacterial solute-binding protein 9 family
A9I65_RS01210	COG2207	Transcriptional regulator
A9I65_RS01210	COG4753	response regulator
A9I65_RS01215	COG2972	Histidine kinase
A9I65_RS01225	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A9I65_RS01230	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A9I65_RS01235	COG0477	Major facilitator Superfamily
A9I65_RS01240	COG2211	Major facilitator Superfamily
A9I65_RS01245	COG3250	beta-galactosidase activity
A9I65_RS01250	COG1957	nucleoside hydrolase
A9I65_RS01280	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A9I65_RS01285	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
A9I65_RS01290	COG2807	transmembrane transport
A9I65_RS01295	COG1396	sequence-specific DNA binding
A9I65_RS01310	COG1785	Belongs to the alkaline phosphatase family
A9I65_RS01315	COG0494	nUDIX hydrolase
A9I65_RS01320	COG0556	nucleotide-excision repair
A9I65_RS01335	COG1510	regulation of RNA biosynthetic process
A9I65_RS01340	COG1012	belongs to the aldehyde dehydrogenase family
A9I65_RS01345	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A9I65_RS01350	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A9I65_RS01360	COG0156	8-amino-7-oxononanoate synthase activity
A9I65_RS01375	COG0107	imidazoleglycerol-phosphate synthase activity
A9I65_RS01380	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A9I65_RS01395	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A9I65_RS01400	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A9I65_RS01405	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A9I65_RS01410	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A9I65_RS01450	COG2376	Dihydroxyacetone kinase
A9I65_RS01455	COG1461	Dihydroxyacetone kinase
A9I65_RS01460	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
A9I65_RS01465	COG2824	Alkylphosphonate utilization operon protein PhnA
A9I65_RS01470	COG1012	belongs to the aldehyde dehydrogenase family
A9I65_RS01485	COG0596	Alpha beta hydrolase
A9I65_RS01490	COG0789	Transcriptional regulator
A9I65_RS01495	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A9I65_RS01495	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A9I65_RS01495	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A9I65_RS01505	COG3942	CHAP domain
A9I65_RS01505	COG1705	Flagellar rod assembly protein muramidase FlgJ
A9I65_RS01515	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A9I65_RS01520	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A9I65_RS01525	COG0747	negative chemotaxis
A9I65_RS01550	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A9I65_RS01550	COG0463	Glycosyl transferase, family 2
A9I65_RS01565	COG0778	Nitroreductase
A9I65_RS01570	COG3001	Fructosamine kinase
A9I65_RS01595	COG1136	(ABC) transporter
A9I65_RS01600	COG0577	efflux transmembrane transporter activity
A9I65_RS01610	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A9I65_RS01620	COG4413	Urea transporter
A9I65_RS01630	COG0832	Belongs to the urease beta subunit family
A9I65_RS01635	COG0804	urea catabolic process
A9I65_RS01640	COG0717	Belongs to the dCTP deaminase family
A9I65_RS01645	COG0523	cobalamin synthesis protein
A9I65_RS01655	COG1141	Ferredoxin
A9I65_RS01680	COG0583	DNA-binding transcription factor activity
A9I65_RS01690	COG1346	cytolysis
A9I65_RS01700	COG1846	Transcriptional regulator
A9I65_RS01705	COG0778	Nitroreductase
A9I65_RS01710	COG2357	RelA SpoT domain protein
A9I65_RS01750	COG1028	Short-chain dehydrogenase reductase Sdr
A9I65_RS01765	COG3835	regulator
A9I65_RS01770	COG2855	membrane
A9I65_RS01775	COG3961	Belongs to the TPP enzyme family
A9I65_RS01780	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A9I65_RS01785	COG0512	Glutamine amidotransferase of anthranilate synthase
A9I65_RS01795	COG0134	indole-3-glycerol-phosphate synthase activity
A9I65_RS01805	COG0133	tryptophan synthase activity
A9I65_RS01810	COG0159	tryptophan synthase activity
A9I65_RS01830	COG0277	FAD linked oxidase domain protein
A9I65_RS01835	COG0247	lactate metabolic process
A9I65_RS01840	COG1132	(ABC) transporter
A9I65_RS01845	COG1132	(ABC) transporter
A9I65_RS01850	COG0789	Transcriptional regulator
A9I65_RS01860	COG3871	stress protein (general stress protein 26)
A9I65_RS01865	COG1115	amino acid carrier protein
A9I65_RS01870	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
A9I65_RS01875	COG2814	Major facilitator Superfamily
A9I65_RS01880	COG2271	Major facilitator Superfamily
A9I65_RS01885	COG3764	Sortase (surface protein transpeptidase)
A9I65_RS01890	COG1929	Belongs to the glycerate kinase type-1 family
A9I65_RS01900	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
A9I65_RS01920	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A9I65_RS01925	COG0702	epimerase
A9I65_RS01935	COG0444	Belongs to the ABC transporter superfamily
A9I65_RS01940	COG4608	Belongs to the ABC transporter superfamily
A9I65_RS01945	COG0601	transmembrane transport
A9I65_RS01950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A9I65_RS01955	COG4166	transmembrane transport
A9I65_RS01960	COG0444	Belongs to the ABC transporter superfamily
A9I65_RS01965	COG4608	Belongs to the ABC transporter superfamily
A9I65_RS01970	COG0601	transmembrane transport
A9I65_RS01975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A9I65_RS01985	COG1760	l-serine dehydratase
A9I65_RS01990	COG1760	l-serine dehydratase
A9I65_RS02045	COG0471	metal ion transport
A9I65_RS02050	COG2116	formate transmembrane transporter activity
A9I65_RS02055	COG0454	-acetyltransferase
A9I65_RS02065	COG1648	precorrin-2 dehydrogenase activity
A9I65_RS02065	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A9I65_RS02070	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A9I65_RS02075	COG2146	nitrite reductase [NAD(P)H] activity
A9I65_RS02080	COG1648	precorrin-2 dehydrogenase activity
A9I65_RS02080	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A9I65_RS02085	COG0737	Belongs to the 5'-nucleotidase family
A9I65_RS02095	COG0018	arginyl-trna synthetase
A9I65_RS02105	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A9I65_RS02110	COG1140	nitrate reductase beta subunit
A9I65_RS02120	COG2181	nitrate reductase activity
A9I65_RS02130	COG4585	Histidine kinase
A9I65_RS02135	COG2197	response regulator
A9I65_RS02140	COG2223	nitrite transmembrane transporter activity
A9I65_RS02145	COG4187	Peptidase family M20/M25/M40
A9I65_RS02155	COG0039	L-malate dehydrogenase activity
A9I65_RS02160	COG1363	Peptidase, m42
A9I65_RS02165	COG0697	spore germination
A9I65_RS02175	COG2807	transmembrane transport
A9I65_RS02185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A9I65_RS02185	COG1263	PTS System
A9I65_RS02200	COG1283	sodium-dependent phosphate transmembrane transporter activity
A9I65_RS02225	COG0492	ferredoxin-NADP+ reductase activity
A9I65_RS02230	COG2814	Major facilitator Superfamily
A9I65_RS02235	COG0604	alcohol dehydrogenase
A9I65_RS02250	COG1620	l-lactate permease
A9I65_RS02265	COG0438	transferase activity, transferring glycosyl groups
A9I65_RS02270	COG0579	oxidoreductase
A9I65_RS02285	COG0577	efflux transmembrane transporter activity
A9I65_RS02320	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A9I65_RS02330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A9I65_RS02350	COG1304	FMN binding
A9I65_RS02355	COG0523	cobalamin synthesis protein
A9I65_RS02360	COG0786	glutamate:sodium symporter activity
A9I65_RS02365	COG2207	Transcriptional regulator
A9I65_RS02390	COG1757	Na H antiporter
A9I65_RS02400	COG3152	Membrane
A9I65_RS02405	COG4152	abc transporter atp-binding protein
A9I65_RS02410	COG1668	transmembrane transport
A9I65_RS02415	COG1742	UPF0060 membrane protein
A9I65_RS02420	COG2017	converts alpha-aldose to the beta-anomer
A9I65_RS02425	COG2258	MOSC domain
A9I65_RS02430	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A9I65_RS02440	COG1266	CAAX protease self-immunity
A9I65_RS02445	COG0583	DNA-binding transcription factor activity
A9I65_RS02450	COG3314	Sporulation integral membrane protein YlbJ
A9I65_RS02455	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A9I65_RS02460	COG1228	amidohydrolase
A9I65_RS02465	COG0659	secondary active sulfate transmembrane transporter activity
A9I65_RS02470	COG1473	amidohydrolase
A9I65_RS02490	COG0385	Bile acid
A9I65_RS02500	COG0346	lactoylglutathione lyase activity
A9I65_RS02505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A9I65_RS02530	COG1113	amino acid transport
A9I65_RS02550	COG1316	TRANSCRIPTIONal
A9I65_RS02565	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
A9I65_RS02570	COG3383	formate dehydrogenase (NAD+) activity
A9I65_RS02595	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A9I65_RS02600	COG2076	Multidrug Resistance protein
A9I65_RS02605	COG2076	Multidrug Resistance protein
A9I65_RS02610	COG3942	CHAP domain
A9I65_RS02620	COG1757	Na H antiporter
A9I65_RS02630	COG3942	CHAP domain
A9I65_RS02650	COG1960	acyl-CoA dehydrogenase activity
A9I65_RS02655	COG2832	Protein of unknown function (DUF454)
A9I65_RS02660	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A9I65_RS02665	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A9I65_RS02675	COG2186	Transcriptional regulator
A9I65_RS02685	COG1268	BioY protein
A9I65_RS02700	COG1609	Transcriptional regulator
A9I65_RS02705	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A9I65_RS02710	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A9I65_RS02715	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
A9I65_RS02730	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A9I65_RS02735	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A9I65_RS02740	COG0521	Mo-molybdopterin cofactor biosynthetic process
A9I65_RS02760	COG0314	molybdopterin synthase activity
A9I65_RS02770	COG0746	molybdenum cofactor guanylyltransferase activity
A9I65_RS02775	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A9I65_RS02800	COG2348	transferase activity, transferring amino-acyl groups
A9I65_RS02805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A9I65_RS02810	COG0436	Aminotransferase
A9I65_RS02835	COG2252	PERMEase
A9I65_RS02855	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A9I65_RS02860	COG0088	Forms part of the polypeptide exit tunnel
A9I65_RS02865	COG0089	rRNA binding
A9I65_RS02870	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A9I65_RS02875	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A9I65_RS02880	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A9I65_RS02885	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A9I65_RS02890	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A9I65_RS02895	COG0255	Belongs to the universal ribosomal protein uL29 family
A9I65_RS02905	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A9I65_RS02920	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A9I65_RS02925	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A9I65_RS02930	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A9I65_RS02940	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A9I65_RS02945	COG1841	ribosomal large subunit assembly
A9I65_RS02955	COG0201	protein transport
A9I65_RS02970	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A9I65_RS02980	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A9I65_RS02985	COG0202	RNA polymerase activity
A9I65_RS02990	COG0203	ribosomal protein L17
A9I65_RS02995	COG1122	ATPase activity
A9I65_RS03000	COG1122	ATPase activity
A9I65_RS03010	COG0101	tRNA pseudouridine synthase activity
A9I65_RS03015	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A9I65_RS03020	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A9I65_RS03070	COG1349	DNA-binding transcription factor activity
A9I65_RS03085	COG3684	Belongs to the aldolase LacD family
A9I65_RS03095	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A9I65_RS03095	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A9I65_RS03105	COG0488	(ABC) transporter
A9I65_RS03110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A9I65_RS03120	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A9I65_RS03135	COG1302	Protein conserved in bacteria
A9I65_RS03140	COG2814	Major facilitator Superfamily
A9I65_RS03145	COG4264	IucA IucC family
A9I65_RS03150	COG2814	Major facilitator Superfamily
A9I65_RS03155	COG4264	IucA IucC family
A9I65_RS03160	COG3457	Alanine racemase
A9I65_RS03165	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A9I65_RS03170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A9I65_RS03175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A9I65_RS03180	COG3314	Sporulation integral membrane protein YlbJ
A9I65_RS03195	COG4284	Utp--glucose-1-phosphate uridylyltransferase
A9I65_RS03200	COG1272	protein, Hemolysin III
A9I65_RS03220	COG2814	Major facilitator Superfamily
A9I65_RS03225	COG0489	protein tyrosine kinase activity
A9I65_RS03290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A9I65_RS03305	COG3711	transcriptional antiterminator
A9I65_RS03325	COG1119	ATPase activity
A9I65_RS03330	COG0561	phosphatase activity
A9I65_RS03340	COG2186	Transcriptional regulator
A9I65_RS03345	COG1482	cell wall glycoprotein biosynthetic process
A9I65_RS03365	COG1757	Na H antiporter
A9I65_RS03375	COG0813	purine-nucleoside phosphorylase activity
A9I65_RS03415	COG5146	pantothenate kinase activity
A9I65_RS03435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A9I65_RS03440	COG3343	RNA polymerase activity
A9I65_RS03445	COG0504	CTP synthase activity
A9I65_RS03450	COG2271	Major facilitator Superfamily
A9I65_RS03460	COG2271	Major facilitator Superfamily
A9I65_RS03465	COG4821	SIS domain
A9I65_RS03475	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A9I65_RS03480	COG1733	regulation of RNA biosynthetic process
A9I65_RS03490	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A9I65_RS03495	COG0254	rRNA binding
A9I65_RS03505	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A9I65_RS03510	COG2890	protein-(glutamine-N5) methyltransferase activity
A9I65_RS03515	COG0009	L-threonylcarbamoyladenylate synthase
A9I65_RS03520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A9I65_RS03525	COG4475	Protein of unknown function (DUF436)
A9I65_RS03530	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A9I65_RS03535	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A9I65_RS03540	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A9I65_RS03550	COG0356	it plays a direct role in the translocation of protons across the membrane
A9I65_RS03555	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A9I65_RS03565	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A9I65_RS03575	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A9I65_RS03605	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A9I65_RS03620	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A9I65_RS03630	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A9I65_RS03635	COG0352	thiamine-phosphate diphosphorylase activity
A9I65_RS03640	COG0706	membrane insertase activity
A9I65_RS03645	COG1418	mRNA catabolic process
A9I65_RS03650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A9I65_RS03655	COG1937	Protein conserved in bacteria
A9I65_RS03670	COG2217	Heavy metal translocating P-type atpase
A9I65_RS03690	COG0772	Belongs to the SEDS family
A9I65_RS03695	COG1181	Belongs to the D-alanine--D-alanine ligase family
A9I65_RS03700	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A9I65_RS03705	COG0513	Belongs to the DEAD box helicase family
A9I65_RS03720	COG3402	PFAM membrane-flanked domain
A9I65_RS03725	COG0736	holo-[acyl-carrier-protein] synthase activity
A9I65_RS03730	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A9I65_RS03740	COG2337	Toxic component of a toxin-antitoxin (TA) module
A9I65_RS03745	COG2208	phosphoserine phosphatase activity
A9I65_RS03750	COG1366	Belongs to the anti-sigma-factor antagonist family
A9I65_RS03760	COG1191	sigma factor activity
A9I65_RS03765	COG2183	response to ionizing radiation
A9I65_RS03770	COG3091	SprT-like family
A9I65_RS03815	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A9I65_RS03825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A9I65_RS03830	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A9I65_RS03840	COG0028	Belongs to the TPP enzyme family
A9I65_RS03850	COG0802	atpase or kinase
A9I65_RS03855	COG1214	PFAM Peptidase M22, glycoprotease
A9I65_RS03860	COG0456	acetyltransferase
A9I65_RS03865	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A9I65_RS03870	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A9I65_RS03875	COG0488	(ABC) transporter
A9I65_RS03880	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A9I65_RS03885	COG2814	Major facilitator Superfamily
A9I65_RS03890	COG1846	Transcriptional regulator
A9I65_RS03900	COG2124	cytochrome p450
A9I65_RS03905	COG1609	Transcriptional regulator
A9I65_RS03910	COG1621	beta-fructofuranosidase activity
A9I65_RS03915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A9I65_RS03935	COG4512	PFAM Accessory gene regulator B
A9I65_RS03970	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A9I65_RS03975	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A9I65_RS03990	COG1131	(ABC) transporter
A9I65_RS04005	COG1070	Carbohydrate kinase
A9I65_RS04010	COG2610	gluconate transmembrane transporter activity
A9I65_RS04040	COG2706	6-phosphogluconolactonase activity
A9I65_RS04045	COG1012	belongs to the aldehyde dehydrogenase family
A9I65_RS04055	COG1227	inorganic diphosphatase activity
A9I65_RS04060	COG1335	isochorismatase
A9I65_RS04070	COG1605	Chorismate mutase
A9I65_RS04070	COG0077	Prephenate dehydratase
A9I65_RS04080	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A9I65_RS04090	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
A9I65_RS04100	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A9I65_RS04105	COG4496	protein, YerC YecD
A9I65_RS04110	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
A9I65_RS04115	COG0210	DNA helicase
A9I65_RS04120	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A9I65_RS04125	COG4851	CamS sex pheromone cAM373 precursor
A9I65_RS04130	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A9I65_RS04135	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A9I65_RS04145	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A9I65_RS04150	COG1597	lipid kinase activity
A9I65_RS04175	COG0488	(ABC) transporter
A9I65_RS04180	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A9I65_RS04185	COG1396	sequence-specific DNA binding
A9I65_RS04205	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A9I65_RS04215	COG1528	Iron-storage protein
A9I65_RS04230	COG4129	membrane
A9I65_RS04235	COG0024	Methionine aminopeptidase
A9I65_RS04260	COG0288	reversible hydration of carbon dioxide
A9I65_RS04265	COG1295	ribonuclease BN
A9I65_RS04280	COG4840	Belongs to the UPF0435 family
A9I65_RS04285	COG2309	aminopeptidase activity
A9I65_RS04290	COG1607	acyl-coa hydrolase
A9I65_RS04295	COG0535	radical SAM domain protein
A9I65_RS04300	COG0693	protein deglycase activity
A9I65_RS04305	COG0028	Belongs to the TPP enzyme family
A9I65_RS04310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A9I65_RS04315	COG2137	regulation of response to DNA damage stimulus
A9I65_RS04325	COG1388	LysM domain
A9I65_RS04325	COG1134	teichoic acid transport
A9I65_RS04335	COG1988	membrane-bound metal-dependent
A9I65_RS04340	COG1194	a g-specific adenine glycosylase
A9I65_RS04345	COG3557	Belongs to the UPF0374 family
A9I65_RS04355	COG0069	glutamate synthase activity
A9I65_RS04360	COG4129	membrane
A9I65_RS04365	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A9I65_RS04370	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A9I65_RS04380	COG0735	belongs to the Fur family
A9I65_RS04615	COG0765	amino acid transport
A9I65_RS04620	COG1126	abc transporter atp-binding protein
A9I65_RS04625	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A9I65_RS04635	COG0363	glucosamine-6-phosphate deaminase activity
A9I65_RS04645	COG0114	fumarate hydratase activity
A9I65_RS04650	COG0248	Ppx GppA phosphatase
A9I65_RS04655	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A9I65_RS04660	COG0564	pseudouridine synthase activity
A9I65_RS04665	COG4585	Histidine kinase
A9I65_RS04665	COG2203	Gaf domain
A9I65_RS04670	COG2197	response regulator
A9I65_RS04680	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A9I65_RS04690	COG4399	Belongs to the UPF0754 family
A9I65_RS04695	COG3679	Belongs to the UPF0342 family
A9I65_RS04700	COG0420	3'-5' exonuclease activity
A9I65_RS04710	COG3481	metal-dependent phosphohydrolase, HD sub domain
A9I65_RS04715	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A9I65_RS04725	COG1846	Transcriptional regulator
A9I65_RS04735	COG0537	adenosine 5'-monophosphoramidase activity
A9I65_RS04740	COG1131	(ABC) transporter
A9I65_RS04745	COG4473	ABC transporter
A9I65_RS04755	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A9I65_RS04770	COG3545	Serine hydrolase
A9I65_RS04855	COG3037	sugar-specific permease SgaT UlaA
A9I65_RS04875	COG3623	hexulose-6-phosphate isomerase
A9I65_RS04880	COG0235	Class ii aldolase
A9I65_RS04900	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A9I65_RS04905	COG0494	nUDIX hydrolase
A9I65_RS04910	COG1506	peptidase
A9I65_RS04915	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A9I65_RS04920	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A9I65_RS04930	COG0656	L-ascorbic acid biosynthetic process
A9I65_RS04935	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A9I65_RS04950	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A9I65_RS04975	COG4193	domain, Protein
A9I65_RS04975	COG3266	domain, Protein
A9I65_RS04975	COG5632	N-Acetylmuramoyl-L-alanine amidase
A9I65_RS04985	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A9I65_RS04985	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A9I65_RS04990	COG0307	riboflavin synthase, alpha
A9I65_RS04995	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A9I65_RS04995	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A9I65_RS05000	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A9I65_RS05015	COG2267	carboxylic ester hydrolase activity
A9I65_RS05020	COG0039	L-malate dehydrogenase activity
A9I65_RS05030	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A9I65_RS05035	COG1242	4 iron, 4 sulfur cluster binding
A9I65_RS05040	COG2814	Major facilitator Superfamily
A9I65_RS05045	COG0495	leucyl-tRNA aminoacylation
A9I65_RS05050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A9I65_RS05055	COG2081	HI0933 family
A9I65_RS05060	COG2244	polysaccharide biosynthetic process
A9I65_RS05065	COG1187	pseudouridine synthase activity
A9I65_RS05080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A9I65_RS05085	COG0510	thiamine kinase activity
A9I65_RS05090	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A9I65_RS05095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A9I65_RS05105	COG1363	Peptidase, m42
A9I65_RS05110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A9I65_RS05115	COG4848	Belongs to the UPF0354 family
A9I65_RS05120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A9I65_RS05125	COG1674	ftsk spoiiie
A9I65_RS05130	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A9I65_RS05135	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
A9I65_RS05145	COG1605	Chorismate mutase
A9I65_RS05145	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A9I65_RS05150	COG1609	Transcriptional regulator
A9I65_RS05165	COG0454	-acetyltransferase
A9I65_RS05170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A9I65_RS05175	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A9I65_RS05180	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A9I65_RS05190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A9I65_RS05195	COG0204	Acyl-transferase
A9I65_RS05205	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A9I65_RS05210	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A9I65_RS05215	COG1764	response to oxidative stress
A9I65_RS05250	COG0456	acetyltransferase
A9I65_RS05280	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A9I65_RS05285	COG1956	GAF domain-containing protein
A9I65_RS05295	COG1104	cysteine desulfurase activity
A9I65_RS05300	COG0301	tRNA thio-modification
A9I65_RS05310	COG0616	signal peptide processing
A9I65_RS05315	COG1714	RDD family
A9I65_RS05320	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A9I65_RS05325	COG0827	DNA restriction-modification system
A9I65_RS05330	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A9I65_RS05335	COG0589	response to stress
A9I65_RS05340	COG0686	Belongs to the AlaDH PNT family
A9I65_RS05350	COG0006	proline dipeptidase activity
A9I65_RS05355	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A9I65_RS05365	COG4109	DRTGG domain
A9I65_RS05370	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A9I65_RS05375	COG0587	DNA-directed DNA polymerase activity
A9I65_RS05380	COG0281	malic enzyme
A9I65_RS05390	COG0825	malonyl-CoA metabolic process
A9I65_RS05395	COG0205	6-phosphofructokinase activity
A9I65_RS05400	COG0469	pyruvate kinase activity
A9I65_RS05405	COG0372	Belongs to the citrate synthase family
A9I65_RS05410	COG0538	isocitrate dehydrogenase activity
A9I65_RS05415	COG0745	RESPONSE REGULATOR receiver
A9I65_RS05420	COG5002	protein histidine kinase activity
A9I65_RS05425	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A9I65_RS05425	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A9I65_RS05435	COG0237	dephospho-CoA kinase activity
A9I65_RS05450	COG3611	Membrane attachment protein
A9I65_RS05455	COG1484	DNA-dependent DNA replication
A9I65_RS05465	COG0833	amino acid
A9I65_RS05470	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A9I65_RS05475	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A9I65_RS05480	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A9I65_RS05495	COG0544	peptidyl-prolyl cis-trans isomerase activity
A9I65_RS05505	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A9I65_RS05510	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A9I65_RS05520	COG0181	hydroxymethylbilane synthase activity
A9I65_RS05535	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A9I65_RS05545	COG2818	Glycosylase
A9I65_RS05550	COG0525	valine-tRNA ligase activity
A9I65_RS05555	COG0285	dihydrofolate synthase activity
A9I65_RS05565	COG2003	Belongs to the UPF0758 family
A9I65_RS05595	COG2868	ribosomal protein
A9I65_RS05605	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A9I65_RS05615	COG0632	four-way junction helicase activity
A9I65_RS05620	COG2255	four-way junction helicase activity
A9I65_RS05625	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A9I65_RS05635	COG1862	Preprotein translocase
A9I65_RS05640	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A9I65_RS05640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A9I65_RS05645	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A9I65_RS05645	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A9I65_RS05650	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A9I65_RS05660	COG1490	D-aminoacyl-tRNA deacylase activity
A9I65_RS05665	COG0860	N-Acetylmuramoyl-L-alanine amidase
A9I65_RS05675	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A9I65_RS05685	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A9I65_RS05690	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A9I65_RS05695	COG1959	2 iron, 2 sulfur cluster binding
A9I65_RS05710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A9I65_RS05715	COG1104	cysteine desulfurase activity
A9I65_RS05720	COG0482	sulfurtransferase activity
A9I65_RS05730	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A9I65_RS05735	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A9I65_RS05740	COG4472	Bacterial protein of unknown function (DUF965)
A9I65_RS05745	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A9I65_RS05750	COG3906	Belongs to the UPF0473 family
A9I65_RS05755	COG4122	O-methyltransferase activity
A9I65_RS05760	COG0826	peptidase U32
A9I65_RS05765	COG0826	peptidase U32
A9I65_RS05770	COG0572	uridine kinase
A9I65_RS05785	COG1984	allophanate hydrolase subunit 2
A9I65_RS05790	COG0511	ligase activity, forming carbon-carbon bonds
A9I65_RS05795	COG0439	Biotin carboxylase
A9I65_RS05800	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A9I65_RS05805	COG1914	H( )-stimulated, divalent metal cation uptake system
A9I65_RS05810	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A9I65_RS05815	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A9I65_RS05820	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A9I65_RS05825	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A9I65_RS05830	COG1534	Rna-binding protein
A9I65_RS05840	COG1713	HD superfamily hydrolase involved in NAD metabolism
A9I65_RS05845	COG0799	negative regulation of ribosome biogenesis
A9I65_RS05850	COG2226	methyltransferase
A9I65_RS05855	COG1555	photosystem II stabilization
A9I65_RS05855	COG1596	polysaccharide export
A9I65_RS05860	COG2131	deaminase
A9I65_RS05870	COG1466	dna polymerase III delta subunit
A9I65_RS05875	COG0268	Binds directly to 16S ribosomal RNA
A9I65_RS05885	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A9I65_RS05905	COG0484	heat shock protein binding
A9I65_RS05910	COG2264	protein methyltransferase activity
A9I65_RS05915	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A9I65_RS05920	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A9I65_RS05935	COG1030	water channel activity
A9I65_RS05940	COG4864	UPF0365 protein
A9I65_RS05950	COG1702	phosphate starvation-inducible protein PhoH
A9I65_RS05960	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A9I65_RS05970	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A9I65_RS05975	COG1381	Involved in DNA repair and RecF pathway recombination
A9I65_RS05980	COG0423	glycine-tRNA ligase activity
A9I65_RS05985	COG0517	IMP dehydrogenase activity
A9I65_RS05990	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A9I65_RS05995	COG0358	DNA primase activity
A9I65_RS06000	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A9I65_RS06005	COG2384	SAM-dependent methyltransferase
A9I65_RS06010	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A9I65_RS06015	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A9I65_RS06020	COG0513	Belongs to the DEAD box helicase family
A9I65_RS06025	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A9I65_RS06030	COG1121	(ABC) transporter
A9I65_RS06035	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A9I65_RS06040	COG0735	belongs to the Fur family
A9I65_RS06045	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A9I65_RS06055	COG0768	penicillin binding
A9I65_RS06060	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A9I65_RS06065	COG0573	inorganic phosphate transmembrane transporter activity
A9I65_RS06070	COG0581	inorganic phosphate transmembrane transporter activity
A9I65_RS06075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A9I65_RS06080	COG0704	Plays a role in the regulation of phosphate uptake
A9I65_RS06090	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A9I65_RS06095	COG0705	Rhomboid family
A9I65_RS06100	COG4483	Protein conserved in bacteria
A9I65_RS06105	COG1940	carbohydrate kinase activity
A9I65_RS06110	COG0011	TIGRFAM Protein of
A9I65_RS06115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A9I65_RS06120	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A9I65_RS06125	COG0582	viral genome integration into host DNA
A9I65_RS06215	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A9I65_RS06375	COG4824	toxin secretion phage lysis holin
A9I65_RS06405	COG3969	phosphoadenosine phosphosulfate
A9I65_RS06410	COG1475	DNA binding
A9I65_RS06415	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A9I65_RS06445	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A9I65_RS06450	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A9I65_RS06460	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A9I65_RS06465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A9I65_RS06470	COG0095	Lipoate-protein ligase
A9I65_RS06485	COG0006	proline dipeptidase activity
A9I65_RS06490	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A9I65_RS06495	COG0511	ligase activity, forming carbon-carbon bonds
A9I65_RS06500	COG0439	Biotin carboxylase
A9I65_RS06505	COG1302	Protein conserved in bacteria
A9I65_RS06515	COG1570	exodeoxyribonuclease VII activity
A9I65_RS06520	COG1722	exodeoxyribonuclease VII activity
A9I65_RS06530	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A9I65_RS06535	COG1438	arginine binding
A9I65_RS06540	COG0497	DNA recombination
A9I65_RS06545	COG0280	phosphate acetyltransferase
A9I65_RS06555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A9I65_RS06560	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A9I65_RS06565	COG0022	dehydrogenase e1 component
A9I65_RS06570	COG0508	dehydrogenase complex catalyzes the overall conversion of
A9I65_RS06585	COG2195	Cleaves the N-terminal amino acid of tripeptides
A9I65_RS06620	COG1234	tRNA 3'-trailer cleavage
A9I65_RS06635	COG0667	Aldo Keto reductase
A9I65_RS06640	COG0494	nUDIX hydrolase
A9I65_RS06645	COG0735	belongs to the Fur family
A9I65_RS06660	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A9I65_RS06670	COG1187	pseudouridine synthase activity
A9I65_RS06675	COG0745	RESPONSE REGULATOR receiver
A9I65_RS06690	COG1141	Ferredoxin
A9I65_RS06700	COG0514	ATP-dependent DNA helicase (RecQ)
A9I65_RS06710	COG0492	ferredoxin-NADP+ reductase activity
A9I65_RS06715	COG0252	asparaginase activity
A9I65_RS06725	COG0539	negative regulation of cytoplasmic translation
A9I65_RS06730	COG1160	GTP binding
A9I65_RS06735	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A9I65_RS06755	COG0142	geranyltranstransferase activity
A9I65_RS06760	COG0105	UTP biosynthetic process
A9I65_RS06770	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A9I65_RS06780	COG0457	Tetratricopeptide repeat
A9I65_RS06785	COG5582	Belongs to the UPF0302 family
A9I65_RS06790	COG4347	Protein of unknown function (DUF1405)
A9I65_RS06800	COG1694	Mazg nucleotide pyrophosphohydrolase
A9I65_RS06805	COG0438	transferase activity, transferring glycosyl groups
A9I65_RS06825	COG0017	Asparaginyl-tRNA synthetase
A9I65_RS06835	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A9I65_RS06845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A9I65_RS06845	COG4499	WXG100 protein secretion system (Wss), protein YukC
A9I65_RS06860	COG4474	Belongs to the UPF0398 family
A9I65_RS06865	COG3599	regulation of cell shape
A9I65_RS06875	COG0116	Belongs to the methyltransferase superfamily
A9I65_RS06880	COG2962	Rard protein
A9I65_RS06885	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A9I65_RS06890	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A9I65_RS06900	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A9I65_RS06910	COG1413	lyase activity
A9I65_RS06945	COG2190	(PTS) system
A9I65_RS06955	COG0793	Belongs to the peptidase S41A family
A9I65_RS06970	COG0671	phosphoesterase, PA-phosphatase related
A9I65_RS06980	COG5002	protein histidine kinase activity
A9I65_RS07010	COG0714	Associated with various cellular activities
A9I65_RS07015	COG4548	von Willebrand factor, type A
A9I65_RS07020	COG1114	Component of the transport system for branched-chain amino acids
A9I65_RS07025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A9I65_RS07030	COG3853	Toxic anion resistance protein (TelA)
A9I65_RS07050	COG1278	Cold shock
A9I65_RS07070	COG1473	amidohydrolase
A9I65_RS07075	COG2171	N-acyltransferase activity
A9I65_RS07080	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A9I65_RS07085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A9I65_RS07090	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A9I65_RS07095	COG0488	(ABC) transporter
A9I65_RS07100	COG2996	Protein conserved in bacteria
A9I65_RS07130	COG1363	Peptidase, m42
A9I65_RS07135	COG0287	Prephenate dehydrogenase
A9I65_RS07140	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A9I65_RS07150	COG1942	4-Oxalocrotonate Tautomerase
A9I65_RS07170	COG0628	permease
A9I65_RS07180	COG3711	transcriptional antiterminator
A9I65_RS07185	COG1115	amino acid carrier protein
A9I65_RS07190	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A9I65_RS07200	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A9I65_RS07205	COG4841	protein insertion into membrane
A9I65_RS07210	COG0824	Thioesterase
A9I65_RS07220	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A9I65_RS07225	COG1970	mechanosensitive ion channel activity
A9I65_RS07230	COG0419	ATPase involved in DNA repair
A9I65_RS07235	COG0420	3'-5' exonuclease activity
A9I65_RS07240	COG4846	Membrane protein involved in cytochrome C biogenesis
A9I65_RS07245	COG3763	UPF0154 protein
A9I65_RS07255	COG4224	UPF0291 protein
A9I65_RS07265	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A9I65_RS07275	COG0516	GMP reductase activity
A9I65_RS07280	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A9I65_RS07290	COG0833	amino acid
A9I65_RS07305	COG0083	homoserine kinase activity
A9I65_RS07310	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A9I65_RS07315	COG0460	homoserine dehydrogenase
A9I65_RS07320	COG0527	aspartate kinase activity
A9I65_RS07340	COG1525	nuclease
A9I65_RS07370	COG0584	glycerophosphoryl diester phosphodiesterase
A9I65_RS07450	COG0789	Transcriptional regulator
A9I65_RS07455	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
A9I65_RS07460	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A9I65_RS07465	COG0386	Belongs to the glutathione peroxidase family
A9I65_RS07475	COG2267	carboxylic ester hydrolase activity
A9I65_RS07480	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A9I65_RS07485	COG1923	regulation of RNA biosynthetic process
A9I65_RS07490	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A9I65_RS07500	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A9I65_RS07505	COG1619	proteins homologs of microcin C7 resistance protein MccF
A9I65_RS07510	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
A9I65_RS07535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A9I65_RS07545	COG1013	pyruvate-flavodoxin oxidoreductase activity
A9I65_RS07550	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A9I65_RS07550	COG0674	pyruvate-flavodoxin oxidoreductase activity
A9I65_RS07555	COG1692	metallophosphoesterase
A9I65_RS07575	COG1418	mRNA catabolic process
A9I65_RS07580	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A9I65_RS07585	COG1546	Belongs to the CinA family
A9I65_RS07585	COG1058	Belongs to the CinA family
A9I65_RS07605	COG0300	oxidoreductase activity
A9I65_RS07610	COG0612	Peptidase, M16
A9I65_RS07615	COG0612	Peptidase, M16
A9I65_RS07635	COG1185	polyribonucleotide nucleotidyltransferase activity
A9I65_RS07645	COG0196	riboflavin kinase activity
A9I65_RS07650	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A9I65_RS07665	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A9I65_RS07670	COG1358	cellular component organization or biogenesis
A9I65_RS07675	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A9I65_RS07680	COG0195	Participates in both transcription termination and antitermination
A9I65_RS07685	COG0779	Required for maturation of 30S ribosomal subunits
A9I65_RS07695	COG0442	prolyl-tRNA aminoacylation
A9I65_RS07705	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A9I65_RS07710	COG4589	Belongs to the CDS family
A9I65_RS07720	COG0233	cytoplasmic translational termination
A9I65_RS07725	COG0528	UMP kinase activity
A9I65_RS07730	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A9I65_RS07735	COG0052	Belongs to the universal ribosomal protein uS2 family
A9I65_RS07740	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A9I65_RS07745	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A9I65_RS07750	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A9I65_RS07755	COG4974	Belongs to the 'phage' integrase family
A9I65_RS07760	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A9I65_RS07765	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A9I65_RS07770	COG0758	DNA mediated transformation
A9I65_RS07780	COG0045	succinate-CoA ligase (ADP-forming) activity
A9I65_RS07790	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A9I65_RS07805	COG4485	Bacterial membrane protein, YfhO
A9I65_RS07845	COG0336	Belongs to the RNA methyltransferase TrmD family
A9I65_RS07850	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A9I65_RS07855	COG0228	four-way junction DNA binding
A9I65_RS07890	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A9I65_RS07895	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
A9I65_RS07900	COG0552	protein localization to endoplasmic reticulum
A9I65_RS07905	COG1196	nuclear chromosome segregation
A9I65_RS07910	COG0571	ribonuclease III activity
A9I65_RS07915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A9I65_RS07930	COG0416	fatty acid biosynthetic process
A9I65_RS07935	COG1349	DNA-binding transcription factor activity
A9I65_RS07945	COG1760	l-serine dehydratase
A9I65_RS07950	COG1760	l-serine dehydratase
A9I65_RS07960	COG1302	Protein conserved in bacteria
A9I65_RS07975	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A9I65_RS07980	COG1162	GTPase activity
A9I65_RS07985	COG2124	cytochrome p450
A9I65_RS08000	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A9I65_RS08005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A9I65_RS08005	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A9I65_RS08015	COG0242	peptide deformylase activity
A9I65_RS08020	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A9I65_RS08025	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A9I65_RS08040	COG1758	RNA polymerase activity
A9I65_RS08060	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A9I65_RS08065	COG0284	orotidine-5'-phosphate decarboxylase activity
A9I65_RS08070	COG0167	dihydroorotate dehydrogenase activity
A9I65_RS08080	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A9I65_RS08085	COG0505	Belongs to the CarA family
A9I65_RS08105	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A9I65_RS08110	COG0564	pseudouridine synthase activity
A9I65_RS08115	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A9I65_RS08125	COG3599	regulation of cell shape
A9I65_RS08145	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A9I65_RS08160	COG4975	Glucose uptake
A9I65_RS08165	COG1869	D-ribose catabolic process
A9I65_RS08170	COG0762	integral membrane protein
A9I65_RS08175	COG1799	cell septum assembly
A9I65_RS08180	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A9I65_RS08190	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A9I65_RS08195	COG0849	cell division
A9I65_RS08205	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A9I65_RS08215	COG0768	penicillin binding
A9I65_RS08220	COG4839	cell division protein FtsL
A9I65_RS08225	COG0275	rRNA processing
A9I65_RS08230	COG2001	Belongs to the MraZ family
A9I65_RS08235	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
A9I65_RS08240	COG0454	-acetyltransferase
A9I65_RS08245	COG1011	Hydrolase
A9I65_RS08255	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A9I65_RS08300	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A9I65_RS08305	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A9I65_RS08310	COG1053	succinate dehydrogenase
A9I65_RS08315	COG2009	succinate dehydrogenase
A9I65_RS08320	COG0322	excinuclease ABC activity
A9I65_RS08325	COG3118	belongs to the thioredoxin family
A9I65_RS08330	COG1193	negative regulation of DNA recombination
A9I65_RS08335	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A9I65_RS08335	COG1796	DNA polymerase
A9I65_RS08350	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A9I65_RS08365	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A9I65_RS08375	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A9I65_RS08395	COG0742	ribosomal rna small subunit methyltransferase
A9I65_RS08405	COG4471	UPF0298 protein
A9I65_RS08410	COG0584	glycerophosphoryl diester phosphodiesterase
A9I65_RS08415	COG3679	Belongs to the UPF0342 family
A9I65_RS08430	COG0109	protoheme IX farnesyltransferase activity
A9I65_RS08450	COG3344	reverse transcriptase
A9I65_RS08455	COG0772	Belongs to the SEDS family
A9I65_RS08460	COG4838	Belongs to the UPF0358 family
A9I65_RS08465	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A9I65_RS08470	COG4896	Protein conserved in bacteria
A9I65_RS08475	COG1902	pentaerythritol trinitrate reductase activity
A9I65_RS08480	COG1217	gtp-binding protein TYPA
A9I65_RS08490	COG0483	inositol monophosphate 1-phosphatase activity
A9I65_RS08495	COG4493	Belongs to the UPF0637 family
A9I65_RS08510	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A9I65_RS08515	COG1177	transmembrane transport
A9I65_RS08525	COG3842	ATPase activity
A9I65_RS08535	COG4476	Belongs to the UPF0223 family
A9I65_RS08575	COG5503	Protein of unknown function (DUF1447)
A9I65_RS08580	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A9I65_RS08585	COG0492	ferredoxin-NADP+ reductase activity
A9I65_RS08605	COG0569	domain protein
A9I65_RS08610	COG1294	oxidase, subunit
A9I65_RS08615	COG1271	oxidase subunit
A9I65_RS08620	COG1393	Belongs to the ArsC family
A9I65_RS08625	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A9I65_RS08630	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A9I65_RS08640	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A9I65_RS08655	COG4172	Belongs to the ABC transporter superfamily
A9I65_RS08665	COG0151	Belongs to the GarS family
A9I65_RS08670	COG0138	bifunctional purine biosynthesis protein purh
A9I65_RS08680	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A9I65_RS08685	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A9I65_RS08695	COG0047	phosphoribosylformylglycinamidine synthase activity
A9I65_RS08700	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A9I65_RS08705	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A9I65_RS08710	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A9I65_RS08715	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A9I65_RS08720	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A9I65_RS08725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A9I65_RS08725	COG1017	nitric oxide dioxygenase activity
A9I65_RS08735	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A9I65_RS08745	COG1845	cytochrome c oxidase, subunit III
A9I65_RS08750	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A9I65_RS08760	COG3973	AAA domain
A9I65_RS08800	COG3212	peptidase
A9I65_RS08815	COG1134	teichoic acid transport
A9I65_RS08825	COG1682	transport, permease protein
A9I65_RS08835	COG1215	transferase activity, transferring glycosyl groups
A9I65_RS08845	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A9I65_RS08855	COG1316	TRANSCRIPTIONal
A9I65_RS08880	COG3594	Acyltransferase
A9I65_RS08885	COG0436	Aminotransferase
A9I65_RS08890	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A9I65_RS08900	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A9I65_RS08905	COG1169	isochorismate synthase
A9I65_RS08910	COG1575	Belongs to the MenA family. Type 1 subfamily
A9I65_RS08915	COG0390	transport system, permease component
A9I65_RS08920	COG4619	ABC transporter
A9I65_RS08940	COG4873	Protein conserved in bacteria
A9I65_RS08995	COG2378	regulation of single-species biofilm formation
A9I65_RS09005	COG0456	acetyltransferase
A9I65_RS09015	COG2226	methyltransferase
A9I65_RS09070	COG0737	Belongs to the 5'-nucleotidase family
A9I65_RS09080	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A9I65_RS09085	COG1696	Membrane protein involved in D-alanine export
A9I65_RS09095	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A9I65_RS09100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A9I65_RS09105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A9I65_RS09110	COG0861	Integral membrane protein TerC family
A9I65_RS09115	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A9I65_RS09125	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A9I65_RS09135	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A9I65_RS09140	COG2814	Major facilitator Superfamily
A9I65_RS09150	COG3715	PTS system
A9I65_RS09155	COG3716	PTS system mannose fructose sorbose family IID component
A9I65_RS09160	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A9I65_RS09165	COG2382	esterase
A9I65_RS09170	COG1115	amino acid carrier protein
A9I65_RS09175	COG0628	permease
A9I65_RS09180	COG4409	exo-alpha-(2->6)-sialidase activity
A9I65_RS09185	COG2211	Major facilitator Superfamily
A9I65_RS09190	COG0673	inositol 2-dehydrogenase activity
A9I65_RS09200	COG0475	glutathione-regulated potassium exporter activity
A9I65_RS09200	COG0569	domain protein
A9I65_RS09205	COG2239	Acts as a magnesium transporter
A9I65_RS09210	COG0564	pseudouridine synthase activity
A9I65_RS09220	COG2357	RelA SpoT domain protein
A9I65_RS09235	COG2346	COG2346, Truncated hemoglobins
A9I65_RS09240	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A9I65_RS09250	COG1164	Oligoendopeptidase f
A9I65_RS09265	COG3591	Belongs to the peptidase S1B family
A9I65_RS09275	COG1393	Belongs to the ArsC family
A9I65_RS09280	COG0180	Tryptophanyl-tRNA synthetase
A9I65_RS09285	COG4166	transmembrane transport
A9I65_RS09290	COG4608	Belongs to the ABC transporter superfamily
A9I65_RS09295	COG0444	Belongs to the ABC transporter superfamily
A9I65_RS09300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A9I65_RS09305	COG0601	transmembrane transport
A9I65_RS09330	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A9I65_RS09350	COG0561	phosphatase activity
A9I65_RS09355	COG0446	pyridine nucleotide-disulphide oxidoreductase
A9I65_RS09360	COG3344	reverse transcriptase
A9I65_RS09370	COG0179	Fumarylacetoacetate (FAA) hydrolase
A9I65_RS09380	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A9I65_RS09395	COG0166	Belongs to the GPI family
A9I65_RS09400	COG0137	argininosuccinate synthase activity
A9I65_RS09410	COG0584	glycerophosphoryl diester phosphodiesterase
A9I65_RS09430	COG1098	S1 RNA binding domain
A9I65_RS09445	COG1278	Cold shock
A9I65_RS09485	COG1131	(ABC) transporter
A9I65_RS09510	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A9I65_RS09520	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A9I65_RS09520	COG2111	Na H antiporter
A9I65_RS09525	COG2111	Na H antiporter
A9I65_RS09530	COG1006	Multisubunit Na H antiporter MnhC subunit
A9I65_RS09535	COG0651	ATP synthesis coupled electron transport
A9I65_RS09540	COG1863	multisubunit Na H antiporter MnhE subunit
A9I65_RS09545	COG2212	antiporter activity
A9I65_RS09550	COG1320	monovalent cation:proton antiporter activity
A9I65_RS09560	COG2056	Na+-H+ antiporter family
A9I65_RS09565	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A9I65_RS09570	COG1252	NADH dehydrogenase
A9I65_RS09575	COG0316	Belongs to the HesB IscA family
A9I65_RS09580	COG4844	belongs to the
A9I65_RS09585	COG1252	NADH dehydrogenase
A9I65_RS09590	COG4837	Protein of unknown function (DUF1462)
A9I65_RS09595	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A9I65_RS09600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A9I65_RS09605	COG0647	UMP catabolic process
A9I65_RS09610	COG2445	Protein of unknown function DUF86
A9I65_RS09620	COG4470	Protein conserved in bacteria
A9I65_RS09625	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A9I65_RS09630	COG0737	Belongs to the 5'-nucleotidase family
A9I65_RS09635	COG0730	response to heat
A9I65_RS09640	COG1801	Protein of unknown function DUF72
A9I65_RS09655	COG1253	flavin adenine dinucleotide binding
A9I65_RS09665	COG1388	LysM domain
A9I65_RS09665	COG5632	N-Acetylmuramoyl-L-alanine amidase
A9I65_RS09780	COG1783	phage Terminase large subunit
A9I65_RS09785	COG5484	DNA packaging
A9I65_RS09785	COG3728	DNA packaging
A9I65_RS09800	COG0756	dUTP diphosphatase activity
A9I65_RS09845	COG0305	Participates in initiation and elongation during chromosome replication
A9I65_RS09955	COG0719	Fe-S assembly protein
A9I65_RS09960	COG0822	iron-sulfur transferase activity
A9I65_RS09970	COG0719	Fe-S assembly protein
A9I65_RS09975	COG0396	ATPase activity
A9I65_RS09985	COG2124	cytochrome p450
A9I65_RS09990	COG1162	GTPase activity
A9I65_RS09995	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A9I65_RS10010	COG1302	Protein conserved in bacteria
A9I65_RS10020	COG1760	l-serine dehydratase
A9I65_RS10025	COG1760	l-serine dehydratase
A9I65_RS10035	COG1764	response to oxidative stress
A9I65_RS10050	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A9I65_RS10070	COG0346	lactoylglutathione lyase activity
A9I65_RS10100	COG0557	exoribonuclease II activity
A9I65_RS10105	COG1647	Serine aminopeptidase, S33
A9I65_RS10110	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A9I65_RS10145	COG0148	phosphopyruvate hydratase activity
A9I65_RS10150	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A9I65_RS10155	COG0149	triose-phosphate isomerase activity
A9I65_RS10160	COG0126	phosphoglycerate kinase activity
A9I65_RS10180	COG1090	epimerase
A9I65_RS10190	COG0740	serine-type endopeptidase activity
A9I65_RS10215	COG4824	toxin secretion phage lysis holin
A9I65_RS10425	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A9I65_RS10445	COG1481	regulation of sporulation
A9I65_RS10450	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A9I65_RS10455	COG1660	Displays ATPase and GTPase activities
A9I65_RS10470	COG0110	maltose O-acetyltransferase activity
A9I65_RS10475	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A9I65_RS10480	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A9I65_RS10510	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A9I65_RS10530	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A9I65_RS10540	COG1739	Uncharacterized protein family UPF0029
A9I65_RS10545	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A9I65_RS10565	COG2195	Cleaves the N-terminal amino acid of tripeptides
A9I65_RS10570	COG1929	Belongs to the glycerate kinase type-1 family
A9I65_RS10575	COG3118	belongs to the thioredoxin family
A9I65_RS10590	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A9I65_RS10600	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A9I65_RS10605	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A9I65_RS10635	COG3104	oligopeptide transport
A9I65_RS10640	COG3104	oligopeptide transport
A9I65_RS10655	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A9I65_RS10660	COG1174	glycine betaine transport
A9I65_RS10665	COG1125	glycine betaine transport
A9I65_RS10665	COG0517	IMP dehydrogenase activity
A9I65_RS10670	COG0514	ATP-dependent DNA helicase (RecQ)
A9I65_RS10675	COG0488	(ABC) transporter
A9I65_RS10685	COG2274	protein secretion by the type I secretion system
A9I65_RS10700	COG0463	Glycosyl transferase, family 2
A9I65_RS10710	COG1368	sulfuric ester hydrolase activity
A9I65_RS10720	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A9I65_RS10740	COG0512	Glutamine amidotransferase of anthranilate synthase
A9I65_RS10750	COG0720	synthase
A9I65_RS10755	COG0602	queuosine metabolic process
A9I65_RS10770	COG0463	Glycosyl transferase, family 2
A9I65_RS10775	COG1253	flavin adenine dinucleotide binding
A9I65_RS10780	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A9I65_RS10780	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A9I65_RS10780	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A9I65_RS10785	COG1105	Belongs to the carbohydrate kinase PfkB family
A9I65_RS10790	COG1349	DNA-binding transcription factor activity
A9I65_RS10810	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A9I65_RS10835	COG0039	L-malate dehydrogenase activity
A9I65_RS10850	COG4989	oxidoreductase activity
A9I65_RS10855	COG0523	cobalamin synthesis protein
A9I65_RS10865	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A9I65_RS10870	COG4988	ABC transporter
A9I65_RS10875	COG1968	undecaprenyl-diphosphatase activity
A9I65_RS10885	COG1671	Belongs to the UPF0178 family
A9I65_RS10890	COG1611	Belongs to the LOG family
A9I65_RS10920	COG2839	Protein conserved in bacteria
A9I65_RS10925	COG2814	Major facilitator Superfamily
A9I65_RS10930	COG0583	DNA-binding transcription factor activity
A9I65_RS10945	COG0217	transcriptional regulatory protein
A9I65_RS10950	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A9I65_RS10955	COG2022	thiamine diphosphate biosynthetic process
A9I65_RS10965	COG0352	thiamine-phosphate diphosphorylase activity
A9I65_RS10975	COG1388	LysM domain
A9I65_RS10975	COG3942	CHAP domain
A9I65_RS10980	COG0306	phosphate transporter
A9I65_RS10985	COG1392	Phosphate transport regulator
A9I65_RS10990	COG0577	efflux transmembrane transporter activity
A9I65_RS10995	COG1136	(ABC) transporter
A9I65_RS11005	COG0745	RESPONSE REGULATOR receiver
A9I65_RS11010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A9I65_RS11015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A9I65_RS11025	COG3949	Membrane
A9I65_RS11040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A9I65_RS11045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A9I65_RS11055	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A9I65_RS11060	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A9I65_RS11080	COG1132	(ABC) transporter
A9I65_RS11085	COG1686	Belongs to the peptidase S11 family
A9I65_RS11105	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A9I65_RS11110	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A9I65_RS11115	COG1682	transport, permease protein
A9I65_RS11125	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A9I65_RS11130	COG0110	maltose O-acetyltransferase activity
A9I65_RS11140	COG1475	DNA binding
A9I65_RS11145	COG0019	diaminopimelate decarboxylase activity
A9I65_RS11165	COG2814	Major facilitator Superfamily
A9I65_RS11170	COG4264	IucA IucC family
A9I65_RS11175	COG2423	ornithine cyclodeaminase activity
A9I65_RS11185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A9I65_RS11190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A9I65_RS11195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A9I65_RS11205	COG1121	(ABC) transporter
A9I65_RS11210	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A9I65_RS11225	COG1320	monovalent cation:proton antiporter activity
A9I65_RS11230	COG2212	antiporter activity
A9I65_RS11235	COG1863	multisubunit Na H antiporter MnhE subunit
A9I65_RS11245	COG1006	Multisubunit Na H antiporter MnhC subunit
A9I65_RS11250	COG2111	Na H antiporter
A9I65_RS11255	COG2111	Na H antiporter
A9I65_RS11255	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A9I65_RS11305	COG0546	phosphoglycolate phosphatase activity
A9I65_RS11310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A9I65_RS11315	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A9I65_RS11320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A9I65_RS11325	COG0805	protein transport
A9I65_RS11330	COG0018	arginyl-trna synthetase
A9I65_RS11345	COG1078	dGTPase activity
A9I65_RS11355	COG4844	belongs to the
A9I65_RS11450	COG0095	Lipoate-protein ligase
A9I65_RS11475	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A9I65_RS11480	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A9I65_RS11490	COG2814	Major facilitator Superfamily
A9I65_RS11495	COG1566	PFAM secretion protein HlyD family protein
A9I65_RS11505	COG2311	Membrane
A9I65_RS11520	COG2363	Small membrane protein
A9I65_RS11555	COG0318	PFAM AMP-dependent synthetase and ligase
A9I65_RS11560	COG0588	phosphoglycerate mutase activity
A9I65_RS11565	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A9I65_RS11570	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A9I65_RS11580	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A9I65_RS11595	COG1263	PTS System
A9I65_RS11595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A9I65_RS11595	COG2190	(PTS) system
A9I65_RS11610	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A9I65_RS11615	COG1469	GTP cyclohydrolase I activity
A9I65_RS11645	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A9I65_RS11650	COG1136	(ABC) transporter
A9I65_RS11650	COG0577	efflux transmembrane transporter activity
A9I65_RS11665	COG0561	phosphatase activity
A9I65_RS11675	COG1428	Deoxynucleoside kinase
A9I65_RS11680	COG1428	Deoxynucleoside kinase
A9I65_RS11685	COG0546	phosphoglycolate phosphatase activity
A9I65_RS11710	COG0488	(ABC) transporter
A9I65_RS11715	COG1121	(ABC) transporter
A9I65_RS11740	COG1473	amidohydrolase
A9I65_RS11745	COG3527	Alpha-acetolactate decarboxylase
A9I65_RS11750	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A9I65_RS11760	COG0049	tRNA binding
A9I65_RS11765	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A9I65_RS11775	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A9I65_RS11780	COG0085	RNA polymerase activity
A9I65_RS11785	COG2813	Specifically methylates the guanine in position
A9I65_RS11795	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A9I65_RS11800	COG0081	regulation of translation
A9I65_RS11805	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A9I65_RS11810	COG0250	Participates in transcription elongation, termination and antitermination
A9I65_RS11815	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A9I65_RS11835	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
A9I65_RS11840	COG0215	cysteine-tRNA ligase activity
A9I65_RS11845	COG1045	serine acetyltransferase
A9I65_RS11850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A9I65_RS11860	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A9I65_RS11865	COG4956	integral membrane protein (PIN domain superfamily)
A9I65_RS11870	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A9I65_RS11905	COG0542	response to heat
A9I65_RS11910	COG3869	Catalyzes the specific phosphorylation of arginine residues in
A9I65_RS11915	COG3880	PFAM UvrB UvrC protein
A9I65_RS11925	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A9I65_RS11935	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
A9I65_RS11940	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
A9I65_RS11945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A9I65_RS11950	COG1289	transmembrane transporter activity
A9I65_RS12070	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A9I65_RS12080	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A9I65_RS12090	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A9I65_RS12100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A9I65_RS12115	COG1098	S1 RNA binding domain
A9I65_RS12125	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A9I65_RS12130	COG3956	TIGRFAM MazG family protein
A9I65_RS12135	COG2244	polysaccharide biosynthetic process
A9I65_RS12140	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A9I65_RS12145	COG0193	aminoacyl-tRNA hydrolase activity
A9I65_RS12155	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A9I65_RS12160	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A9I65_RS12165	COG2088	sporulation resulting in formation of a cellular spore
A9I65_RS12170	COG0251	oxidation-reduction process
A9I65_RS12175	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A9I65_RS12180	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A9I65_RS12185	COG4466	Protein conserved in bacteria
A9I65_RS12195	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A9I65_RS12200	COG0084	hydrolase, TatD family'
A9I65_RS12210	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A9I65_RS12215	COG2827	Endonuclease containing a URI domain
A9I65_RS12220	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A9I65_RS12225	COG4467	Involved in initiation control of chromosome replication
A9I65_RS12230	COG1774	PSP1 C-terminal conserved region
A9I65_RS12235	COG0470	DNA polymerase III
A9I65_RS12240	COG3870	Protein conserved in bacteria
A9I65_RS12245	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A9I65_RS12250	COG1982	Orn Lys Arg decarboxylase major
A9I65_RS12275	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A9I65_RS12280	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A9I65_RS12285	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A9I65_RS12290	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A9I65_RS12300	COG2188	Transcriptional regulator
A9I65_RS12305	COG0366	Alpha amylase catalytic
A9I65_RS12310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A9I65_RS12310	COG1263	PTS System
A9I65_RS12320	COG0493	'glutamate synthase
A9I65_RS12325	COG0067	glutamate synthase
A9I65_RS12325	COG0070	glutamate synthase
A9I65_RS12325	COG0069	glutamate synthase activity
A9I65_RS12330	COG0583	DNA-binding transcription factor activity
A9I65_RS12345	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A9I65_RS12360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A9I65_RS12370	COG0535	radical SAM domain protein
A9I65_RS12375	COG1131	(ABC) transporter
A9I65_RS12425	COG0626	cystathionine gamma-synthase activity
A9I65_RS12430	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A9I65_RS12435	COG2272	Belongs to the type-B carboxylesterase lipase family
A9I65_RS12440	COG0733	neurotransmitter:sodium symporter activity
A9I65_RS12450	COG0745	RESPONSE REGULATOR receiver
A9I65_RS12455	COG2205	protein histidine kinase activity
A9I65_RS12465	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A9I65_RS12470	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
A9I65_RS12485	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A9I65_RS12490	COG0574	Belongs to the PEP-utilizing enzyme family
A9I65_RS12490	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A9I65_RS12520	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A9I65_RS12530	COG1486	melibiose metabolic process
A9I65_RS12555	COG2210	Belongs to the sulfur carrier protein TusA family
A9I65_RS12560	COG1937	Protein conserved in bacteria
A9I65_RS12565	COG0730	response to heat
A9I65_RS12570	COG2814	Major facilitator Superfamily
A9I65_RS12595	COG3682	Transcriptional regulator
A9I65_RS12620	COG1124	(ABC) transporter
A9I65_RS12625	COG0444	Belongs to the ABC transporter superfamily
A9I65_RS12630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A9I65_RS12635	COG0601	transmembrane transport
A9I65_RS12640	COG0747	negative chemotaxis
A9I65_RS12665	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A9I65_RS12685	COG1525	nuclease
A9I65_RS12725	COG3617	BRO family, N-terminal domain
A9I65_RS12745	COG0582	viral genome integration into host DNA
A9I65_RS12750	COG0519	Catalyzes the synthesis of GMP from XMP
A9I65_RS12750	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A9I65_RS12760	COG2233	PERMEase
A9I65_RS12765	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A9I65_RS12780	COG5183	chlorophyll binding
A9I65_RS12815	COG0778	Nitroreductase
A9I65_RS12820	COG0450	alkyl hydroperoxide reductase
A9I65_RS12835	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A9I65_RS12845	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A9I65_RS12855	COG1464	Belongs to the NlpA lipoprotein family
A9I65_RS12860	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A9I65_RS12865	COG0753	catalase activity
A9I65_RS12875	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A9I65_RS12885	COG0360	Binds together with S18 to 16S ribosomal RNA
A9I65_RS12895	COG1668	transmembrane transport
A9I65_RS12900	COG1131	(ABC) transporter
A9I65_RS12930	COG0012	GTP binding
A9I65_RS12935	COG4481	Protein conserved in bacteria
A9I65_RS12940	COG0668	transmembrane transport
A9I65_RS12945	COG1475	DNA binding
A9I65_RS12950	COG0626	cystathionine gamma-synthase activity
A9I65_RS12955	COG0626	cystathionine gamma-synthase activity
A9I65_RS12960	COG0646	methionine synthase
A9I65_RS12960	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A9I65_RS12970	COG0829	nickel cation binding
A9I65_RS12980	COG0830	nickel cation binding
A9I65_RS12985	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
A9I65_RS12995	COG2388	GCN5-related N-acetyl-transferase
A9I65_RS13000	COG1846	Transcriptional regulator
A9I65_RS13005	COG0346	lactoylglutathione lyase activity
A9I65_RS13010	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A9I65_RS13015	COG0400	carboxylic ester hydrolase activity
A9I65_RS13030	COG0357	Ribosomal RNA small subunit methyltransferase G
A9I65_RS13035	COG0445	tRNA wobble uridine modification
A9I65_RS13040	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A9I65_RS13045	COG0594	ribonuclease P activity