locus-tag	class	description
SPS5912_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SPS5912_RS00010	COG0592	DNA-directed DNA polymerase activity
SPS5912_RS00020	COG2501	S4 domain
SPS5912_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SPS5912_RS00030	COG0187	DNA topoisomerase II activity
SPS5912_RS00040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SPS5912_RS00045	COG2986	histidine ammonia-lyase
SPS5912_RS00055	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
SPS5912_RS00065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SPS5912_RS00070	COG4241	membrane
SPS5912_RS00075	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
SPS5912_RS00080	COG0359	binds to the 23S rRNA
SPS5912_RS00090	COG0305	Participates in initiation and elongation during chromosome replication
SPS5912_RS00095	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SPS5912_RS00100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPS5912_RS00120	COG0745	RESPONSE REGULATOR receiver
SPS5912_RS00125	COG5002	protein histidine kinase activity
SPS5912_RS00130	COG4863	YycH protein
SPS5912_RS00140	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPS5912_RS00145	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SPS5912_RS00170	COG2311	Membrane
SPS5912_RS00190	COG0531	amino acid
SPS5912_RS00195	COG2217	Heavy metal translocating P-type atpase
SPS5912_RS00220	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SPS5912_RS00230	COG0415	Belongs to the DNA photolyase family
SPS5912_RS00245	COG0702	epimerase
SPS5912_RS00250	COG2130	NADP-dependent
SPS5912_RS00265	COG3177	Filamentation induced by cAMP protein fic
SPS5912_RS00270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPS5912_RS00280	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SPS5912_RS00285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPS5912_RS00305	COG2235	arginine
SPS5912_RS00320	COG2197	response regulator
SPS5912_RS00325	COG2203	Gaf domain
SPS5912_RS00325	COG4585	Histidine kinase
SPS5912_RS00330	COG0842	Transport permease protein
SPS5912_RS00335	COG1131	(ABC) transporter
SPS5912_RS00355	COG0431	NADPH-dependent FMN reductase
SPS5912_RS00400	COG1609	Transcriptional regulator
SPS5912_RS00410	COG0673	inositol 2-dehydrogenase activity
SPS5912_RS00420	COG0366	Alpha amylase catalytic
SPS5912_RS00430	COG3833	ABC-type maltose transport systems, permease component
SPS5912_RS00435	COG1175	transmembrane transport
SPS5912_RS00445	COG3842	ATPase activity
SPS5912_RS00450	COG0475	glutathione-regulated potassium exporter activity
SPS5912_RS00455	COG0490	domain, Protein
SPS5912_RS00465	COG0346	lactoylglutathione lyase activity
SPS5912_RS00475	COG0366	Alpha amylase catalytic
SPS5912_RS00480	COG2188	Transcriptional regulator
SPS5912_RS00485	COG2222	sugar isomerase
SPS5912_RS00490	COG1105	Belongs to the carbohydrate kinase PfkB family
SPS5912_RS00505	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPS5912_RS00505	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPS5912_RS00510	COG3715	PTS system
SPS5912_RS00515	COG3716	PTS system mannose fructose sorbose family IID component
SPS5912_RS00525	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SPS5912_RS00545	COG3314	Sporulation integral membrane protein YlbJ
SPS5912_RS00565	COG1063	alcohol dehydrogenase
SPS5912_RS00580	COG1620	l-lactate permease
SPS5912_RS00585	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SPS5912_RS00590	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SPS5912_RS00595	COG0156	8-amino-7-oxononanoate synthase activity
SPS5912_RS00640	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SPS5912_RS00655	COG0076	glutamate decarboxylase activity
SPS5912_RS00670	COG2318	DinB family
SPS5912_RS00675	COG0753	catalase activity
SPS5912_RS00685	COG0783	Belongs to the Dps family
SPS5912_RS00695	COG0436	Aminotransferase
SPS5912_RS00720	COG1136	(ABC) transporter
SPS5912_RS00730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPS5912_RS00740	COG1755	Isoprenylcysteine carboxyl methyltransferase
SPS5912_RS00765	COG0579	oxidoreductase
SPS5912_RS00785	COG1073	alpha beta
SPS5912_RS00805	COG0438	transferase activity, transferring glycosyl groups
SPS5912_RS00810	COG0183	Belongs to the thiolase family
SPS5912_RS00825	COG0318	PFAM AMP-dependent synthetase and ligase
SPS5912_RS00835	COG2814	Major facilitator Superfamily
SPS5912_RS00845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SPS5912_RS00875	COG1609	Transcriptional regulator
SPS5912_RS00880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SPS5912_RS00885	COG1869	D-ribose catabolic process
SPS5912_RS00910	COG3711	transcriptional antiterminator
SPS5912_RS00915	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPS5912_RS00925	COG3037	sugar-specific permease SgaT UlaA
SPS5912_RS00930	COG1328	CTP reductase activity
SPS5912_RS00950	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPS5912_RS00955	COG1942	4-Oxalocrotonate Tautomerase
SPS5912_RS00965	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPS5912_RS00965	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPS5912_RS00990	COG2207	Transcriptional regulator
SPS5912_RS00990	COG4753	response regulator
SPS5912_RS00995	COG2972	Histidine kinase
SPS5912_RS01005	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SPS5912_RS01010	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
SPS5912_RS01015	COG0477	Major facilitator Superfamily
SPS5912_RS01020	COG2211	Major facilitator Superfamily
SPS5912_RS01025	COG3250	beta-galactosidase activity
SPS5912_RS01030	COG1957	nucleoside hydrolase
SPS5912_RS01065	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SPS5912_RS01070	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
SPS5912_RS01075	COG2807	transmembrane transport
SPS5912_RS01080	COG1396	sequence-specific DNA binding
SPS5912_RS01095	COG1785	Belongs to the alkaline phosphatase family
SPS5912_RS01120	COG1510	regulation of RNA biosynthetic process
SPS5912_RS01125	COG1012	belongs to the aldehyde dehydrogenase family
SPS5912_RS01130	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SPS5912_RS01135	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SPS5912_RS01145	COG0156	8-amino-7-oxononanoate synthase activity
SPS5912_RS01160	COG0107	imidazoleglycerol-phosphate synthase activity
SPS5912_RS01165	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SPS5912_RS01180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SPS5912_RS01185	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SPS5912_RS01190	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SPS5912_RS01195	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SPS5912_RS01235	COG2376	Dihydroxyacetone kinase
SPS5912_RS01240	COG1461	Dihydroxyacetone kinase
SPS5912_RS01245	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SPS5912_RS01250	COG2824	Alkylphosphonate utilization operon protein PhnA
SPS5912_RS01255	COG1012	belongs to the aldehyde dehydrogenase family
SPS5912_RS01270	COG0596	Alpha beta hydrolase
SPS5912_RS01275	COG0789	Transcriptional regulator
SPS5912_RS01280	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPS5912_RS01280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPS5912_RS01280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPS5912_RS01290	COG3942	CHAP domain
SPS5912_RS01290	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPS5912_RS01300	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SPS5912_RS01305	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SPS5912_RS01310	COG0747	negative chemotaxis
SPS5912_RS01335	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SPS5912_RS01335	COG0463	Glycosyl transferase, family 2
SPS5912_RS01340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SPS5912_RS01345	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SPS5912_RS01350	COG3344	reverse transcriptase
SPS5912_RS01365	COG3181	Tripartite tricarboxylate transporter family receptor
SPS5912_RS01370	COG0778	Nitroreductase
SPS5912_RS01375	COG3001	Fructosamine kinase
SPS5912_RS01400	COG1136	(ABC) transporter
SPS5912_RS01405	COG0577	efflux transmembrane transporter activity
SPS5912_RS01415	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
SPS5912_RS01425	COG4413	Urea transporter
SPS5912_RS01435	COG0832	Belongs to the urease beta subunit family
SPS5912_RS01440	COG0804	urea catabolic process
SPS5912_RS01445	COG0717	Belongs to the dCTP deaminase family
SPS5912_RS01450	COG0523	cobalamin synthesis protein
SPS5912_RS01460	COG1141	Ferredoxin
SPS5912_RS01490	COG0583	DNA-binding transcription factor activity
SPS5912_RS01500	COG1346	cytolysis
SPS5912_RS01515	COG1846	Transcriptional regulator
SPS5912_RS01520	COG0778	Nitroreductase
SPS5912_RS01525	COG2357	RelA SpoT domain protein
SPS5912_RS01565	COG1028	Short-chain dehydrogenase reductase Sdr
SPS5912_RS01580	COG3835	regulator
SPS5912_RS01585	COG2855	membrane
SPS5912_RS01590	COG3961	Belongs to the TPP enzyme family
SPS5912_RS01595	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPS5912_RS01600	COG0512	Glutamine amidotransferase of anthranilate synthase
SPS5912_RS01610	COG0134	indole-3-glycerol-phosphate synthase activity
SPS5912_RS01620	COG0133	tryptophan synthase activity
SPS5912_RS01625	COG0159	tryptophan synthase activity
SPS5912_RS01645	COG0277	FAD linked oxidase domain protein
SPS5912_RS01650	COG0247	lactate metabolic process
SPS5912_RS01655	COG1132	(ABC) transporter
SPS5912_RS01660	COG1132	(ABC) transporter
SPS5912_RS01665	COG0789	Transcriptional regulator
SPS5912_RS01675	COG3871	stress protein (general stress protein 26)
SPS5912_RS01680	COG1115	amino acid carrier protein
SPS5912_RS01685	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
SPS5912_RS01690	COG2814	Major facilitator Superfamily
SPS5912_RS01695	COG2271	Major facilitator Superfamily
SPS5912_RS01700	COG3764	Sortase (surface protein transpeptidase)
SPS5912_RS01705	COG1929	Belongs to the glycerate kinase type-1 family
SPS5912_RS01715	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
SPS5912_RS01735	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPS5912_RS01740	COG0702	epimerase
SPS5912_RS01745	COG4166	transmembrane transport
SPS5912_RS01750	COG0444	Belongs to the ABC transporter superfamily
SPS5912_RS01755	COG4608	Belongs to the ABC transporter superfamily
SPS5912_RS01760	COG0601	transmembrane transport
SPS5912_RS01765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPS5912_RS01770	COG4166	transmembrane transport
SPS5912_RS01775	COG0444	Belongs to the ABC transporter superfamily
SPS5912_RS01780	COG4608	Belongs to the ABC transporter superfamily
SPS5912_RS01785	COG0601	transmembrane transport
SPS5912_RS01790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPS5912_RS01800	COG1760	l-serine dehydratase
SPS5912_RS01805	COG1760	l-serine dehydratase
SPS5912_RS01860	COG0471	metal ion transport
SPS5912_RS01865	COG2116	formate transmembrane transporter activity
SPS5912_RS01870	COG0454	-acetyltransferase
SPS5912_RS01880	COG1648	precorrin-2 dehydrogenase activity
SPS5912_RS01880	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SPS5912_RS01885	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SPS5912_RS01890	COG2146	nitrite reductase [NAD(P)H] activity
SPS5912_RS01895	COG1648	precorrin-2 dehydrogenase activity
SPS5912_RS01895	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SPS5912_RS01900	COG0737	Belongs to the 5'-nucleotidase family
SPS5912_RS01915	COG0018	arginyl-trna synthetase
SPS5912_RS01935	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
SPS5912_RS01940	COG1140	nitrate reductase beta subunit
SPS5912_RS01950	COG2181	nitrate reductase activity
SPS5912_RS01960	COG4585	Histidine kinase
SPS5912_RS01965	COG2197	response regulator
SPS5912_RS01975	COG2223	nitrite transmembrane transporter activity
SPS5912_RS01980	COG3344	reverse transcriptase
SPS5912_RS01985	COG4187	Peptidase family M20/M25/M40
SPS5912_RS01995	COG0039	L-malate dehydrogenase activity
SPS5912_RS02000	COG1363	Peptidase, m42
SPS5912_RS02005	COG0697	spore germination
SPS5912_RS02015	COG2807	transmembrane transport
SPS5912_RS02025	COG1263	PTS System
SPS5912_RS02025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPS5912_RS02040	COG1283	sodium-dependent phosphate transmembrane transporter activity
SPS5912_RS02060	COG0492	ferredoxin-NADP+ reductase activity
SPS5912_RS02065	COG2814	Major facilitator Superfamily
SPS5912_RS02070	COG0604	alcohol dehydrogenase
SPS5912_RS02085	COG1620	l-lactate permease
SPS5912_RS02090	COG0438	transferase activity, transferring glycosyl groups
SPS5912_RS02095	COG0579	oxidoreductase
SPS5912_RS02110	COG0577	efflux transmembrane transporter activity
SPS5912_RS02145	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SPS5912_RS02155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPS5912_RS02175	COG1304	FMN binding
SPS5912_RS02180	COG0523	cobalamin synthesis protein
SPS5912_RS02185	COG0786	glutamate:sodium symporter activity
SPS5912_RS02190	COG2207	Transcriptional regulator
SPS5912_RS02195	COG3250	beta-galactosidase activity
SPS5912_RS02215	COG1757	Na H antiporter
SPS5912_RS02220	COG2094	Belongs to the DNA glycosylase MPG family
SPS5912_RS02225	COG3152	Membrane
SPS5912_RS02230	COG4152	abc transporter atp-binding protein
SPS5912_RS02235	COG1668	transmembrane transport
SPS5912_RS02240	COG1742	UPF0060 membrane protein
SPS5912_RS02245	COG2017	converts alpha-aldose to the beta-anomer
SPS5912_RS02250	COG2258	MOSC domain
SPS5912_RS02255	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SPS5912_RS02265	COG1266	CAAX protease self-immunity
SPS5912_RS02270	COG0583	DNA-binding transcription factor activity
SPS5912_RS02275	COG3314	Sporulation integral membrane protein YlbJ
SPS5912_RS02280	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SPS5912_RS02285	COG1228	amidohydrolase
SPS5912_RS02290	COG0659	secondary active sulfate transmembrane transporter activity
SPS5912_RS02295	COG1473	amidohydrolase
SPS5912_RS02315	COG0385	Bile acid
SPS5912_RS02325	COG0346	lactoylglutathione lyase activity
SPS5912_RS02330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SPS5912_RS02355	COG1113	amino acid transport
SPS5912_RS02380	COG1316	TRANSCRIPTIONal
SPS5912_RS02395	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SPS5912_RS02400	COG3383	formate dehydrogenase (NAD+) activity
SPS5912_RS02425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SPS5912_RS02430	COG2076	Multidrug Resistance protein
SPS5912_RS02435	COG2076	Multidrug Resistance protein
SPS5912_RS02440	COG3942	CHAP domain
SPS5912_RS02450	COG1757	Na H antiporter
SPS5912_RS02460	COG3942	CHAP domain
SPS5912_RS02480	COG1960	acyl-CoA dehydrogenase activity
SPS5912_RS02485	COG2832	Protein of unknown function (DUF454)
SPS5912_RS02490	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SPS5912_RS02495	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPS5912_RS02505	COG2186	Transcriptional regulator
SPS5912_RS02515	COG1268	BioY protein
SPS5912_RS02530	COG1609	Transcriptional regulator
SPS5912_RS02535	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SPS5912_RS02540	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPS5912_RS02545	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPS5912_RS02555	COG4149	molybdate abc transporter
SPS5912_RS02560	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SPS5912_RS02565	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SPS5912_RS02570	COG0521	Mo-molybdopterin cofactor biosynthetic process
SPS5912_RS02590	COG0314	molybdopterin synthase activity
SPS5912_RS02600	COG0746	molybdenum cofactor guanylyltransferase activity
SPS5912_RS02605	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SPS5912_RS02630	COG2348	transferase activity, transferring amino-acyl groups
SPS5912_RS02635	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SPS5912_RS02640	COG0436	Aminotransferase
SPS5912_RS02660	COG0551	DNA topoisomerase type I activity
SPS5912_RS02660	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPS5912_RS02665	COG2252	PERMEase
SPS5912_RS02685	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SPS5912_RS02690	COG0088	Forms part of the polypeptide exit tunnel
SPS5912_RS02695	COG0089	rRNA binding
SPS5912_RS02700	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SPS5912_RS02705	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SPS5912_RS02710	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SPS5912_RS02715	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SPS5912_RS02720	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SPS5912_RS02725	COG0255	Belongs to the universal ribosomal protein uL29 family
SPS5912_RS02735	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SPS5912_RS02750	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SPS5912_RS02755	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SPS5912_RS02760	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SPS5912_RS02770	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SPS5912_RS02775	COG1841	ribosomal large subunit assembly
SPS5912_RS02785	COG0201	protein transport
SPS5912_RS02800	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SPS5912_RS02810	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SPS5912_RS02815	COG0202	RNA polymerase activity
SPS5912_RS02820	COG0203	ribosomal protein L17
SPS5912_RS02825	COG1122	ATPase activity
SPS5912_RS02830	COG1122	ATPase activity
SPS5912_RS02840	COG0101	tRNA pseudouridine synthase activity
SPS5912_RS02845	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPS5912_RS02870	COG3344	reverse transcriptase
SPS5912_RS02885	COG1349	DNA-binding transcription factor activity
SPS5912_RS02900	COG3684	Belongs to the aldolase LacD family
SPS5912_RS02910	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPS5912_RS02910	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPS5912_RS02920	COG0488	(ABC) transporter
SPS5912_RS02925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPS5912_RS02935	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SPS5912_RS02950	COG1302	Protein conserved in bacteria
SPS5912_RS02955	COG2814	Major facilitator Superfamily
SPS5912_RS02960	COG4264	IucA IucC family
SPS5912_RS02965	COG2814	Major facilitator Superfamily
SPS5912_RS02970	COG4264	IucA IucC family
SPS5912_RS02975	COG3457	Alanine racemase
SPS5912_RS02980	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
SPS5912_RS02985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPS5912_RS02990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPS5912_RS02995	COG3314	Sporulation integral membrane protein YlbJ
SPS5912_RS03005	COG1988	membrane-bound metal-dependent
SPS5912_RS03010	COG4284	Utp--glucose-1-phosphate uridylyltransferase
SPS5912_RS03015	COG1272	protein, Hemolysin III
SPS5912_RS03035	COG2814	Major facilitator Superfamily
SPS5912_RS03040	COG0489	protein tyrosine kinase activity
SPS5912_RS03105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPS5912_RS03120	COG3711	transcriptional antiterminator
SPS5912_RS03150	COG1119	ATPase activity
SPS5912_RS03155	COG0561	phosphatase activity
SPS5912_RS03165	COG2186	Transcriptional regulator
SPS5912_RS03170	COG1482	cell wall glycoprotein biosynthetic process
SPS5912_RS03185	COG3344	reverse transcriptase
SPS5912_RS03195	COG1757	Na H antiporter
SPS5912_RS03205	COG0813	purine-nucleoside phosphorylase activity
SPS5912_RS03240	COG5146	pantothenate kinase activity
SPS5912_RS03255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPS5912_RS03265	COG0504	CTP synthase activity
SPS5912_RS03270	COG2271	Major facilitator Superfamily
SPS5912_RS03275	COG4821	SIS domain
SPS5912_RS03280	COG0191	fructose-bisphosphate aldolase activity
SPS5912_RS03285	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPS5912_RS03290	COG1733	regulation of RNA biosynthetic process
SPS5912_RS03305	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SPS5912_RS03310	COG0254	rRNA binding
SPS5912_RS03320	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SPS5912_RS03325	COG2890	protein-(glutamine-N5) methyltransferase activity
SPS5912_RS03330	COG0009	L-threonylcarbamoyladenylate synthase
SPS5912_RS03335	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPS5912_RS03340	COG4475	Protein of unknown function (DUF436)
SPS5912_RS03345	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SPS5912_RS03350	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SPS5912_RS03355	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SPS5912_RS03365	COG0356	it plays a direct role in the translocation of protons across the membrane
SPS5912_RS03370	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPS5912_RS03380	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPS5912_RS03390	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SPS5912_RS03420	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SPS5912_RS03435	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SPS5912_RS03445	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SPS5912_RS03450	COG0352	thiamine-phosphate diphosphorylase activity
SPS5912_RS03455	COG0706	membrane insertase activity
SPS5912_RS03460	COG1418	mRNA catabolic process
SPS5912_RS03465	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPS5912_RS03470	COG1937	Protein conserved in bacteria
SPS5912_RS03485	COG2217	Heavy metal translocating P-type atpase
SPS5912_RS03500	COG0772	Belongs to the SEDS family
SPS5912_RS03505	COG1181	Belongs to the D-alanine--D-alanine ligase family
SPS5912_RS03510	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPS5912_RS03515	COG0513	Belongs to the DEAD box helicase family
SPS5912_RS03530	COG3402	PFAM membrane-flanked domain
SPS5912_RS03535	COG0736	holo-[acyl-carrier-protein] synthase activity
SPS5912_RS03540	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SPS5912_RS03550	COG2337	Toxic component of a toxin-antitoxin (TA) module
SPS5912_RS03555	COG2208	phosphoserine phosphatase activity
SPS5912_RS03560	COG1366	Belongs to the anti-sigma-factor antagonist family
SPS5912_RS03570	COG1191	sigma factor activity
SPS5912_RS03575	COG2183	response to ionizing radiation
SPS5912_RS03580	COG3091	SprT-like family
SPS5912_RS03615	COG0515	serine threonine protein kinase
SPS5912_RS03635	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SPS5912_RS03645	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SPS5912_RS03650	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SPS5912_RS03660	COG0028	Belongs to the TPP enzyme family
SPS5912_RS03665	COG0129	dihydroxy-acid dehydratase activity
SPS5912_RS03670	COG0802	atpase or kinase
SPS5912_RS03675	COG1214	PFAM Peptidase M22, glycoprotease
SPS5912_RS03680	COG0456	acetyltransferase
SPS5912_RS03685	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SPS5912_RS03695	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SPS5912_RS03700	COG0488	(ABC) transporter
SPS5912_RS03705	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SPS5912_RS03710	COG0425	Belongs to the sulfur carrier protein TusA family
SPS5912_RS03715	COG2391	methyltransferase activity
SPS5912_RS03720	COG1609	Transcriptional regulator
SPS5912_RS03725	COG1621	beta-fructofuranosidase activity
SPS5912_RS03730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SPS5912_RS03750	COG4512	PFAM Accessory gene regulator B
SPS5912_RS03800	COG1404	Belongs to the peptidase S8 family
SPS5912_RS03805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPS5912_RS03810	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SPS5912_RS03825	COG1131	(ABC) transporter
SPS5912_RS03840	COG1070	Carbohydrate kinase
SPS5912_RS03845	COG2610	gluconate transmembrane transporter activity
SPS5912_RS03875	COG2706	6-phosphogluconolactonase activity
SPS5912_RS03880	COG1012	belongs to the aldehyde dehydrogenase family
SPS5912_RS03890	COG1227	inorganic diphosphatase activity
SPS5912_RS03895	COG1335	isochorismatase
SPS5912_RS03905	COG0077	Prephenate dehydratase
SPS5912_RS03905	COG1605	Chorismate mutase
SPS5912_RS03915	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPS5912_RS03925	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
SPS5912_RS03935	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPS5912_RS03940	COG4496	protein, YerC YecD
SPS5912_RS03945	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
SPS5912_RS03950	COG0210	DNA helicase
SPS5912_RS03955	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SPS5912_RS03960	COG4851	CamS sex pheromone cAM373 precursor
SPS5912_RS03965	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPS5912_RS03970	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SPS5912_RS03980	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SPS5912_RS03985	COG1597	lipid kinase activity
SPS5912_RS04010	COG0488	(ABC) transporter
SPS5912_RS04020	COG1396	sequence-specific DNA binding
SPS5912_RS04025	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SPS5912_RS04030	COG2211	Major facilitator Superfamily
SPS5912_RS04040	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SPS5912_RS04050	COG1528	Iron-storage protein
SPS5912_RS04065	COG4129	membrane
SPS5912_RS04070	COG0024	Methionine aminopeptidase
SPS5912_RS04095	COG0288	reversible hydration of carbon dioxide
SPS5912_RS04100	COG1295	ribonuclease BN
SPS5912_RS04115	COG4840	Belongs to the UPF0435 family
SPS5912_RS04120	COG2309	aminopeptidase activity
SPS5912_RS04125	COG1607	acyl-coa hydrolase
SPS5912_RS04130	COG0535	radical SAM domain protein
SPS5912_RS04135	COG0693	protein deglycase activity
SPS5912_RS04140	COG0028	Belongs to the TPP enzyme family
SPS5912_RS04145	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPS5912_RS04150	COG2137	regulation of response to DNA damage stimulus
SPS5912_RS04160	COG1134	teichoic acid transport
SPS5912_RS04160	COG1388	LysM domain
SPS5912_RS04170	COG1988	membrane-bound metal-dependent
SPS5912_RS04175	COG1194	a g-specific adenine glycosylase
SPS5912_RS04180	COG3557	Belongs to the UPF0374 family
SPS5912_RS04190	COG0069	glutamate synthase activity
SPS5912_RS04195	COG4129	membrane
SPS5912_RS04200	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SPS5912_RS04205	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SPS5912_RS04215	COG0735	belongs to the Fur family
SPS5912_RS04450	COG0765	amino acid transport
SPS5912_RS04455	COG1126	abc transporter atp-binding protein
SPS5912_RS04460	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SPS5912_RS04470	COG0363	glucosamine-6-phosphate deaminase activity
SPS5912_RS04480	COG0114	fumarate hydratase activity
SPS5912_RS04485	COG0248	Ppx GppA phosphatase
SPS5912_RS04490	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SPS5912_RS04495	COG0564	pseudouridine synthase activity
SPS5912_RS04500	COG4585	Histidine kinase
SPS5912_RS04500	COG2203	Gaf domain
SPS5912_RS04505	COG2197	response regulator
SPS5912_RS04510	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPS5912_RS04530	COG4399	Belongs to the UPF0754 family
SPS5912_RS04535	COG3679	Belongs to the UPF0342 family
SPS5912_RS04540	COG0420	3'-5' exonuclease activity
SPS5912_RS04550	COG3481	metal-dependent phosphohydrolase, HD sub domain
SPS5912_RS04555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SPS5912_RS04565	COG1846	Transcriptional regulator
SPS5912_RS04575	COG0537	adenosine 5'-monophosphoramidase activity
SPS5912_RS04580	COG1131	(ABC) transporter
SPS5912_RS04585	COG4473	ABC transporter
SPS5912_RS04590	COG3344	reverse transcriptase
SPS5912_RS04600	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SPS5912_RS04610	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SPS5912_RS04615	COG3545	Serine hydrolase
SPS5912_RS04705	COG3037	sugar-specific permease SgaT UlaA
SPS5912_RS04725	COG3623	hexulose-6-phosphate isomerase
SPS5912_RS04730	COG0235	Class ii aldolase
SPS5912_RS04750	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SPS5912_RS04755	COG0494	nUDIX hydrolase
SPS5912_RS04760	COG1506	peptidase
SPS5912_RS04765	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SPS5912_RS04770	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SPS5912_RS04780	COG0656	L-ascorbic acid biosynthetic process
SPS5912_RS04785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPS5912_RS04790	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPS5912_RS04800	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SPS5912_RS04825	COG3266	domain, Protein
SPS5912_RS04825	COG4193	domain, Protein
SPS5912_RS04825	COG5632	N-Acetylmuramoyl-L-alanine amidase
SPS5912_RS04835	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SPS5912_RS04835	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SPS5912_RS04840	COG0307	riboflavin synthase, alpha
SPS5912_RS04845	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPS5912_RS04845	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPS5912_RS04850	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SPS5912_RS04865	COG2267	carboxylic ester hydrolase activity
SPS5912_RS04870	COG0039	L-malate dehydrogenase activity
SPS5912_RS04880	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SPS5912_RS04885	COG1242	4 iron, 4 sulfur cluster binding
SPS5912_RS04890	COG2814	Major facilitator Superfamily
SPS5912_RS04895	COG0495	leucyl-tRNA aminoacylation
SPS5912_RS04900	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPS5912_RS04905	COG2081	HI0933 family
SPS5912_RS04910	COG2244	polysaccharide biosynthetic process
SPS5912_RS04915	COG1187	pseudouridine synthase activity
SPS5912_RS04925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPS5912_RS04930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPS5912_RS04935	COG0510	thiamine kinase activity
SPS5912_RS04940	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SPS5912_RS04945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SPS5912_RS04955	COG1363	Peptidase, m42
SPS5912_RS04960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPS5912_RS04965	COG4848	Belongs to the UPF0354 family
SPS5912_RS04970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPS5912_RS04975	COG1674	ftsk spoiiie
SPS5912_RS04980	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SPS5912_RS04985	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
SPS5912_RS04995	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SPS5912_RS04995	COG1605	Chorismate mutase
SPS5912_RS05000	COG1609	Transcriptional regulator
SPS5912_RS05010	COG0454	-acetyltransferase
SPS5912_RS05015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SPS5912_RS05020	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SPS5912_RS05025	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SPS5912_RS05035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPS5912_RS05040	COG0204	Acyl-transferase
SPS5912_RS05050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SPS5912_RS05055	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SPS5912_RS05060	COG1764	response to oxidative stress
SPS5912_RS05115	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SPS5912_RS05120	COG1956	GAF domain-containing protein
SPS5912_RS05125	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
SPS5912_RS05130	COG1104	cysteine desulfurase activity
SPS5912_RS05135	COG0301	tRNA thio-modification
SPS5912_RS05145	COG0616	signal peptide processing
SPS5912_RS05150	COG1714	RDD family
SPS5912_RS05155	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SPS5912_RS05160	COG0827	DNA restriction-modification system
SPS5912_RS05165	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SPS5912_RS05175	COG0589	response to stress
SPS5912_RS05180	COG0686	Belongs to the AlaDH PNT family
SPS5912_RS05190	COG0006	proline dipeptidase activity
SPS5912_RS05195	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SPS5912_RS05205	COG4109	DRTGG domain
SPS5912_RS05210	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPS5912_RS05215	COG0587	DNA-directed DNA polymerase activity
SPS5912_RS05220	COG0281	malic enzyme
SPS5912_RS05225	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SPS5912_RS05230	COG0825	malonyl-CoA metabolic process
SPS5912_RS05235	COG0205	6-phosphofructokinase activity
SPS5912_RS05240	COG0469	pyruvate kinase activity
SPS5912_RS05245	COG0372	Belongs to the citrate synthase family
SPS5912_RS05250	COG0538	isocitrate dehydrogenase activity
SPS5912_RS05255	COG0745	RESPONSE REGULATOR receiver
SPS5912_RS05260	COG5002	protein histidine kinase activity
SPS5912_RS05265	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPS5912_RS05265	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPS5912_RS05275	COG0237	dephospho-CoA kinase activity
SPS5912_RS05290	COG3611	Membrane attachment protein
SPS5912_RS05295	COG1484	DNA-dependent DNA replication
SPS5912_RS05305	COG0833	amino acid
SPS5912_RS05310	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SPS5912_RS05315	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SPS5912_RS05335	COG0544	peptidyl-prolyl cis-trans isomerase activity
SPS5912_RS05345	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SPS5912_RS05350	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SPS5912_RS05360	COG0181	hydroxymethylbilane synthase activity
SPS5912_RS05375	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SPS5912_RS05385	COG2818	Glycosylase
SPS5912_RS05390	COG0525	valine-tRNA ligase activity
SPS5912_RS05395	COG0285	dihydrofolate synthase activity
SPS5912_RS05405	COG2003	Belongs to the UPF0758 family
SPS5912_RS05430	COG2868	ribosomal protein
SPS5912_RS05440	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SPS5912_RS05450	COG0632	four-way junction helicase activity
SPS5912_RS05455	COG2255	four-way junction helicase activity
SPS5912_RS05460	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SPS5912_RS05470	COG1862	Preprotein translocase
SPS5912_RS05475	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SPS5912_RS05475	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SPS5912_RS05480	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPS5912_RS05480	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPS5912_RS05485	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPS5912_RS05495	COG1490	D-aminoacyl-tRNA deacylase activity
SPS5912_RS05500	COG0860	N-Acetylmuramoyl-L-alanine amidase
SPS5912_RS05510	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SPS5912_RS05520	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SPS5912_RS05525	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPS5912_RS05530	COG1959	2 iron, 2 sulfur cluster binding
SPS5912_RS05545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPS5912_RS05550	COG1104	cysteine desulfurase activity
SPS5912_RS05555	COG0482	sulfurtransferase activity
SPS5912_RS05565	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPS5912_RS05570	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SPS5912_RS05575	COG4472	Bacterial protein of unknown function (DUF965)
SPS5912_RS05580	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SPS5912_RS05585	COG3906	Belongs to the UPF0473 family
SPS5912_RS05590	COG4122	O-methyltransferase activity
SPS5912_RS05595	COG0826	peptidase U32
SPS5912_RS05600	COG0826	peptidase U32
SPS5912_RS05605	COG0572	uridine kinase
SPS5912_RS05615	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SPS5912_RS05620	COG1984	allophanate hydrolase subunit 2
SPS5912_RS05625	COG0511	ligase activity, forming carbon-carbon bonds
SPS5912_RS05630	COG0439	Biotin carboxylase
SPS5912_RS05635	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SPS5912_RS05640	COG1914	H( )-stimulated, divalent metal cation uptake system
SPS5912_RS05645	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPS5912_RS05650	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SPS5912_RS05655	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPS5912_RS05660	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SPS5912_RS05665	COG1534	Rna-binding protein
SPS5912_RS05675	COG1713	HD superfamily hydrolase involved in NAD metabolism
SPS5912_RS05680	COG0799	negative regulation of ribosome biogenesis
SPS5912_RS05685	COG2226	methyltransferase
SPS5912_RS05690	COG1555	photosystem II stabilization
SPS5912_RS05690	COG1596	polysaccharide export
SPS5912_RS05695	COG2131	deaminase
SPS5912_RS05700	COG2333	competence protein COMEC
SPS5912_RS05700	COG0658	competence protein
SPS5912_RS05705	COG1466	dna polymerase III delta subunit
SPS5912_RS05710	COG0268	Binds directly to 16S ribosomal RNA
SPS5912_RS05720	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPS5912_RS05740	COG0484	heat shock protein binding
SPS5912_RS05745	COG2264	protein methyltransferase activity
SPS5912_RS05750	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPS5912_RS05755	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SPS5912_RS05770	COG1030	water channel activity
SPS5912_RS05775	COG4864	UPF0365 protein
SPS5912_RS05785	COG1702	phosphate starvation-inducible protein PhoH
SPS5912_RS05795	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPS5912_RS05805	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SPS5912_RS05810	COG1381	Involved in DNA repair and RecF pathway recombination
SPS5912_RS05815	COG0423	glycine-tRNA ligase activity
SPS5912_RS05820	COG0517	IMP dehydrogenase activity
SPS5912_RS05825	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SPS5912_RS05830	COG0358	DNA primase activity
SPS5912_RS05835	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPS5912_RS05840	COG2384	SAM-dependent methyltransferase
SPS5912_RS05845	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SPS5912_RS05850	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SPS5912_RS05855	COG0513	Belongs to the DEAD box helicase family
SPS5912_RS05860	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SPS5912_RS05865	COG1121	(ABC) transporter
SPS5912_RS05870	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPS5912_RS05875	COG0735	belongs to the Fur family
SPS5912_RS05880	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SPS5912_RS05890	COG0768	penicillin binding
SPS5912_RS05895	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPS5912_RS05900	COG0573	inorganic phosphate transmembrane transporter activity
SPS5912_RS05905	COG0581	inorganic phosphate transmembrane transporter activity
SPS5912_RS05910	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPS5912_RS05915	COG0704	Plays a role in the regulation of phosphate uptake
SPS5912_RS05925	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SPS5912_RS05930	COG0457	Tetratricopeptide repeat
SPS5912_RS05930	COG0705	Rhomboid family
SPS5912_RS05935	COG4483	Protein conserved in bacteria
SPS5912_RS05940	COG1940	carbohydrate kinase activity
SPS5912_RS05945	COG0011	TIGRFAM Protein of
SPS5912_RS05950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SPS5912_RS05955	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPS5912_RS05990	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SPS5912_RS05995	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SPS5912_RS06005	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SPS5912_RS06010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPS5912_RS06015	COG0095	Lipoate-protein ligase
SPS5912_RS06030	COG0006	proline dipeptidase activity
SPS5912_RS06035	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SPS5912_RS06040	COG0511	ligase activity, forming carbon-carbon bonds
SPS5912_RS06045	COG0439	Biotin carboxylase
SPS5912_RS06050	COG1302	Protein conserved in bacteria
SPS5912_RS06060	COG1570	exodeoxyribonuclease VII activity
SPS5912_RS06065	COG1722	exodeoxyribonuclease VII activity
SPS5912_RS06070	COG0142	geranyltranstransferase activity
SPS5912_RS06075	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SPS5912_RS06080	COG1438	arginine binding
SPS5912_RS06085	COG0497	DNA recombination
SPS5912_RS06090	COG0280	phosphate acetyltransferase
SPS5912_RS06095	COG3426	butyrate kinase activity
SPS5912_RS06100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPS5912_RS06105	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPS5912_RS06110	COG0022	dehydrogenase e1 component
SPS5912_RS06115	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPS5912_RS06125	COG4129	membrane
SPS5912_RS06130	COG2195	Cleaves the N-terminal amino acid of tripeptides
SPS5912_RS06155	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SPS5912_RS06160	COG1234	tRNA 3'-trailer cleavage
SPS5912_RS06165	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPS5912_RS06175	COG0667	Aldo Keto reductase
SPS5912_RS06180	COG0494	nUDIX hydrolase
SPS5912_RS06185	COG0735	belongs to the Fur family
SPS5912_RS06200	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SPS5912_RS06205	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SPS5912_RS06210	COG1187	pseudouridine synthase activity
SPS5912_RS06215	COG0745	RESPONSE REGULATOR receiver
SPS5912_RS06230	COG1141	Ferredoxin
SPS5912_RS06240	COG0514	ATP-dependent DNA helicase (RecQ)
SPS5912_RS06250	COG0492	ferredoxin-NADP+ reductase activity
SPS5912_RS06290	COG0252	asparaginase activity
SPS5912_RS06300	COG0539	negative regulation of cytoplasmic translation
SPS5912_RS06305	COG1160	GTP binding
SPS5912_RS06310	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SPS5912_RS06330	COG0142	geranyltranstransferase activity
SPS5912_RS06335	COG0105	UTP biosynthetic process
SPS5912_RS06345	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SPS5912_RS06355	COG0457	Tetratricopeptide repeat
SPS5912_RS06360	COG5582	Belongs to the UPF0302 family
SPS5912_RS06365	COG4347	Protein of unknown function (DUF1405)
SPS5912_RS06375	COG1694	Mazg nucleotide pyrophosphohydrolase
SPS5912_RS06380	COG0438	transferase activity, transferring glycosyl groups
SPS5912_RS06385	COG0617	tRNA 3'-terminal CCA addition
SPS5912_RS06400	COG0017	Asparaginyl-tRNA synthetase
SPS5912_RS06405	COG3935	DnaD domain protein
SPS5912_RS06410	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPS5912_RS06420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPS5912_RS06420	COG4499	WXG100 protein secretion system (Wss), protein YukC
SPS5912_RS06435	COG4474	Belongs to the UPF0398 family
SPS5912_RS06440	COG3599	regulation of cell shape
SPS5912_RS06450	COG0116	Belongs to the methyltransferase superfamily
SPS5912_RS06455	COG2962	Rard protein
SPS5912_RS06460	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SPS5912_RS06465	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPS5912_RS06475	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SPS5912_RS06485	COG1413	lyase activity
SPS5912_RS06520	COG2190	(PTS) system
SPS5912_RS06530	COG0793	Belongs to the peptidase S41A family
SPS5912_RS06540	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SPS5912_RS06545	COG0671	phosphoesterase, PA-phosphatase related
SPS5912_RS06555	COG5002	protein histidine kinase activity
SPS5912_RS06560	COG0567	Dehydrogenase, E1 component
SPS5912_RS06585	COG0714	Associated with various cellular activities
SPS5912_RS06590	COG4548	von Willebrand factor, type A
SPS5912_RS06595	COG1114	Component of the transport system for branched-chain amino acids
SPS5912_RS06605	COG3853	Toxic anion resistance protein (TelA)
SPS5912_RS06625	COG1278	Cold shock
SPS5912_RS06645	COG1473	amidohydrolase
SPS5912_RS06650	COG2171	N-acyltransferase activity
SPS5912_RS06655	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SPS5912_RS06660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPS5912_RS06665	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SPS5912_RS06670	COG0488	(ABC) transporter
SPS5912_RS06675	COG2996	Protein conserved in bacteria
SPS5912_RS06705	COG1363	Peptidase, m42
SPS5912_RS06710	COG0287	Prephenate dehydrogenase
SPS5912_RS06715	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SPS5912_RS06725	COG1942	4-Oxalocrotonate Tautomerase
SPS5912_RS06745	COG0628	permease
SPS5912_RS06755	COG3711	transcriptional antiterminator
SPS5912_RS06760	COG1115	amino acid carrier protein
SPS5912_RS06765	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPS5912_RS06775	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SPS5912_RS06780	COG4841	protein insertion into membrane
SPS5912_RS06785	COG0824	Thioesterase
SPS5912_RS06795	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SPS5912_RS06800	COG1970	mechanosensitive ion channel activity
SPS5912_RS06805	COG0419	ATPase involved in DNA repair
SPS5912_RS06810	COG0420	3'-5' exonuclease activity
SPS5912_RS06815	COG3344	reverse transcriptase
SPS5912_RS06820	COG4846	Membrane protein involved in cytochrome C biogenesis
SPS5912_RS06825	COG3763	UPF0154 protein
SPS5912_RS06835	COG4224	UPF0291 protein
SPS5912_RS06845	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SPS5912_RS06855	COG0516	GMP reductase activity
SPS5912_RS06860	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SPS5912_RS06870	COG0833	amino acid
SPS5912_RS06885	COG0083	homoserine kinase activity
SPS5912_RS06890	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SPS5912_RS06895	COG0460	homoserine dehydrogenase
SPS5912_RS06900	COG0527	aspartate kinase activity
SPS5912_RS06920	COG3344	reverse transcriptase
SPS5912_RS06925	COG1525	nuclease
SPS5912_RS06955	COG0584	glycerophosphoryl diester phosphodiesterase
SPS5912_RS06975	COG3344	reverse transcriptase
SPS5912_RS06985	COG0789	Transcriptional regulator
SPS5912_RS06990	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SPS5912_RS06995	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPS5912_RS07000	COG0386	Belongs to the glutathione peroxidase family
SPS5912_RS07005	COG2267	carboxylic ester hydrolase activity
SPS5912_RS07010	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SPS5912_RS07015	COG1923	regulation of RNA biosynthetic process
SPS5912_RS07020	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SPS5912_RS07030	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPS5912_RS07035	COG1619	proteins homologs of microcin C7 resistance protein MccF
SPS5912_RS07040	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
SPS5912_RS07045	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SPS5912_RS07065	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SPS5912_RS07075	COG1013	pyruvate-flavodoxin oxidoreductase activity
SPS5912_RS07080	COG0674	pyruvate-flavodoxin oxidoreductase activity
SPS5912_RS07080	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SPS5912_RS07085	COG1692	metallophosphoesterase
SPS5912_RS07105	COG1418	mRNA catabolic process
SPS5912_RS07110	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SPS5912_RS07115	COG1058	Belongs to the CinA family
SPS5912_RS07115	COG1546	Belongs to the CinA family
SPS5912_RS07135	COG0300	oxidoreductase activity
SPS5912_RS07140	COG0612	Peptidase, M16
SPS5912_RS07145	COG0612	Peptidase, M16
SPS5912_RS07150	COG2188	Transcriptional regulator
SPS5912_RS07170	COG1185	polyribonucleotide nucleotidyltransferase activity
SPS5912_RS07180	COG0196	riboflavin kinase activity
SPS5912_RS07185	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SPS5912_RS07190	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SPS5912_RS07200	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SPS5912_RS07205	COG1358	cellular component organization or biogenesis
SPS5912_RS07210	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SPS5912_RS07215	COG0195	Participates in both transcription termination and antitermination
SPS5912_RS07220	COG0779	Required for maturation of 30S ribosomal subunits
SPS5912_RS07230	COG0442	prolyl-tRNA aminoacylation
SPS5912_RS07240	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SPS5912_RS07245	COG4589	Belongs to the CDS family
SPS5912_RS07250	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SPS5912_RS07255	COG0233	cytoplasmic translational termination
SPS5912_RS07260	COG0528	UMP kinase activity
SPS5912_RS07265	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SPS5912_RS07270	COG0052	Belongs to the universal ribosomal protein uS2 family
SPS5912_RS07275	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SPS5912_RS07280	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SPS5912_RS07285	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SPS5912_RS07290	COG4974	Belongs to the 'phage' integrase family
SPS5912_RS07295	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SPS5912_RS07300	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPS5912_RS07305	COG0758	DNA mediated transformation
SPS5912_RS07315	COG0045	succinate-CoA ligase (ADP-forming) activity
SPS5912_RS07325	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SPS5912_RS07340	COG4485	Bacterial membrane protein, YfhO
SPS5912_RS07380	COG0336	Belongs to the RNA methyltransferase TrmD family
SPS5912_RS07385	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SPS5912_RS07390	COG0228	four-way junction DNA binding
SPS5912_RS07400	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SPS5912_RS07445	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPS5912_RS07450	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
SPS5912_RS07455	COG0552	protein localization to endoplasmic reticulum
SPS5912_RS07460	COG1196	nuclear chromosome segregation
SPS5912_RS07465	COG0571	ribonuclease III activity
SPS5912_RS07470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPS5912_RS07485	COG0416	fatty acid biosynthetic process
SPS5912_RS07490	COG1349	DNA-binding transcription factor activity
SPS5912_RS07500	COG1760	l-serine dehydratase
SPS5912_RS07505	COG1760	l-serine dehydratase
SPS5912_RS07515	COG1302	Protein conserved in bacteria
SPS5912_RS07530	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SPS5912_RS07535	COG1162	GTPase activity
SPS5912_RS07540	COG2124	cytochrome p450
SPS5912_RS07555	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SPS5912_RS07560	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPS5912_RS07560	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPS5912_RS07565	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SPS5912_RS07570	COG0242	peptide deformylase activity
SPS5912_RS07575	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPS5912_RS07580	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPS5912_RS07585	COG1758	RNA polymerase activity
SPS5912_RS07605	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SPS5912_RS07610	COG0284	orotidine-5'-phosphate decarboxylase activity
SPS5912_RS07615	COG0167	dihydroorotate dehydrogenase activity
SPS5912_RS07625	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SPS5912_RS07630	COG0505	Belongs to the CarA family
SPS5912_RS07650	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SPS5912_RS07655	COG0564	pseudouridine synthase activity
SPS5912_RS07660	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SPS5912_RS07665	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SPS5912_RS07670	COG3599	regulation of cell shape
SPS5912_RS07690	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPS5912_RS07695	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPS5912_RS07705	COG4975	Glucose uptake
SPS5912_RS07710	COG1869	D-ribose catabolic process
SPS5912_RS07715	COG0762	integral membrane protein
SPS5912_RS07720	COG1799	cell septum assembly
SPS5912_RS07725	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPS5912_RS07735	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SPS5912_RS07740	COG0849	cell division
SPS5912_RS07750	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SPS5912_RS07760	COG0768	penicillin binding
SPS5912_RS07765	COG4839	cell division protein FtsL
SPS5912_RS07770	COG0275	rRNA processing
SPS5912_RS07775	COG2001	Belongs to the MraZ family
SPS5912_RS07780	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
SPS5912_RS07785	COG0454	-acetyltransferase
SPS5912_RS07790	COG1011	Hydrolase
SPS5912_RS07805	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPS5912_RS07840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPS5912_RS07845	COG0783	Belongs to the Dps family
SPS5912_RS07895	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SPS5912_RS07900	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SPS5912_RS07905	COG1053	succinate dehydrogenase
SPS5912_RS07910	COG2009	succinate dehydrogenase
SPS5912_RS07915	COG0322	excinuclease ABC activity
SPS5912_RS07920	COG3118	belongs to the thioredoxin family
SPS5912_RS07925	COG1193	negative regulation of DNA recombination
SPS5912_RS07930	COG1796	DNA polymerase
SPS5912_RS07930	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SPS5912_RS07945	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SPS5912_RS07960	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SPS5912_RS07965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPS5912_RS07970	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SPS5912_RS07990	COG0742	ribosomal rna small subunit methyltransferase
SPS5912_RS08000	COG4471	UPF0298 protein
SPS5912_RS08005	COG0584	glycerophosphoryl diester phosphodiesterase
SPS5912_RS08010	COG3679	Belongs to the UPF0342 family
SPS5912_RS08025	COG0109	protoheme IX farnesyltransferase activity
SPS5912_RS08045	COG3344	reverse transcriptase
SPS5912_RS08050	COG0772	Belongs to the SEDS family
SPS5912_RS08055	COG4838	Belongs to the UPF0358 family
SPS5912_RS08060	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SPS5912_RS08065	COG4896	Protein conserved in bacteria
SPS5912_RS08070	COG1902	pentaerythritol trinitrate reductase activity
SPS5912_RS08075	COG1217	gtp-binding protein TYPA
SPS5912_RS08085	COG0483	inositol monophosphate 1-phosphatase activity
SPS5912_RS08090	COG4493	Belongs to the UPF0637 family
SPS5912_RS08105	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SPS5912_RS08110	COG1177	transmembrane transport
SPS5912_RS08120	COG3842	ATPase activity
SPS5912_RS08130	COG4476	Belongs to the UPF0223 family
SPS5912_RS08170	COG5503	Protein of unknown function (DUF1447)
SPS5912_RS08175	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SPS5912_RS08185	COG0569	domain protein
SPS5912_RS08190	COG1294	oxidase, subunit
SPS5912_RS08195	COG1271	oxidase subunit
SPS5912_RS08200	COG1393	Belongs to the ArsC family
SPS5912_RS08210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SPS5912_RS08215	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPS5912_RS08225	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPS5912_RS08240	COG4172	Belongs to the ABC transporter superfamily
SPS5912_RS08250	COG0151	Belongs to the GarS family
SPS5912_RS08255	COG0138	bifunctional purine biosynthesis protein purh
SPS5912_RS08265	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SPS5912_RS08270	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SPS5912_RS08280	COG0047	phosphoribosylformylglycinamidine synthase activity
SPS5912_RS08285	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPS5912_RS08290	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SPS5912_RS08295	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SPS5912_RS08300	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPS5912_RS08305	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SPS5912_RS08310	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SPS5912_RS08310	COG1017	nitric oxide dioxygenase activity
SPS5912_RS08320	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SPS5912_RS08330	COG1845	cytochrome c oxidase, subunit III
SPS5912_RS08335	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
SPS5912_RS08345	COG3973	AAA domain
SPS5912_RS08390	COG3212	peptidase
SPS5912_RS08405	COG1134	teichoic acid transport
SPS5912_RS08415	COG1682	transport, permease protein
SPS5912_RS08425	COG1215	transferase activity, transferring glycosyl groups
SPS5912_RS08435	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
SPS5912_RS08460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPS5912_RS08465	COG1316	TRANSCRIPTIONal
SPS5912_RS08490	COG3594	Acyltransferase
SPS5912_RS08495	COG0436	Aminotransferase
SPS5912_RS08500	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SPS5912_RS08510	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SPS5912_RS08515	COG1169	isochorismate synthase
SPS5912_RS08520	COG1575	Belongs to the MenA family. Type 1 subfamily
SPS5912_RS08525	COG0390	transport system, permease component
SPS5912_RS08530	COG4619	ABC transporter
SPS5912_RS08540	COG3682	Transcriptional regulator
SPS5912_RS08575	COG4974	Belongs to the 'phage' integrase family
SPS5912_RS08595	COG4873	Protein conserved in bacteria
SPS5912_RS08675	COG3344	reverse transcriptase
SPS5912_RS08700	COG0737	Belongs to the 5'-nucleotidase family
SPS5912_RS08710	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SPS5912_RS08715	COG1696	Membrane protein involved in D-alanine export
SPS5912_RS08725	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SPS5912_RS08730	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPS5912_RS08735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPS5912_RS08740	COG0861	Integral membrane protein TerC family
SPS5912_RS08745	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SPS5912_RS08755	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SPS5912_RS08765	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SPS5912_RS08770	COG2814	Major facilitator Superfamily
SPS5912_RS08780	COG3715	PTS system
SPS5912_RS08785	COG3716	PTS system mannose fructose sorbose family IID component
SPS5912_RS08790	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SPS5912_RS08795	COG2382	esterase
SPS5912_RS08800	COG1115	amino acid carrier protein
SPS5912_RS08805	COG0628	permease
SPS5912_RS08810	COG4409	exo-alpha-(2->6)-sialidase activity
SPS5912_RS08815	COG2211	Major facilitator Superfamily
SPS5912_RS08820	COG0673	inositol 2-dehydrogenase activity
SPS5912_RS08830	COG0475	glutathione-regulated potassium exporter activity
SPS5912_RS08830	COG0569	domain protein
SPS5912_RS08835	COG2239	Acts as a magnesium transporter
SPS5912_RS08840	COG0564	pseudouridine synthase activity
SPS5912_RS08850	COG2357	RelA SpoT domain protein
SPS5912_RS08865	COG2346	COG2346, Truncated hemoglobins
SPS5912_RS08870	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SPS5912_RS08880	COG1164	Oligoendopeptidase f
SPS5912_RS08895	COG3591	Belongs to the peptidase S1B family
SPS5912_RS08905	COG1393	Belongs to the ArsC family
SPS5912_RS08910	COG0180	Tryptophanyl-tRNA synthetase
SPS5912_RS08915	COG4166	transmembrane transport
SPS5912_RS08920	COG4608	Belongs to the ABC transporter superfamily
SPS5912_RS08925	COG0444	Belongs to the ABC transporter superfamily
SPS5912_RS08930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPS5912_RS08935	COG0601	transmembrane transport
SPS5912_RS08960	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SPS5912_RS08985	COG0561	phosphatase activity
SPS5912_RS08990	COG0446	pyridine nucleotide-disulphide oxidoreductase
SPS5912_RS08995	COG3344	reverse transcriptase
SPS5912_RS09005	COG0179	Fumarylacetoacetate (FAA) hydrolase
SPS5912_RS09015	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SPS5912_RS09030	COG0166	Belongs to the GPI family
SPS5912_RS09035	COG0137	argininosuccinate synthase activity
SPS5912_RS09045	COG0584	glycerophosphoryl diester phosphodiesterase
SPS5912_RS09060	COG1012	belongs to the aldehyde dehydrogenase family
SPS5912_RS09065	COG1098	S1 RNA binding domain
SPS5912_RS09075	COG1278	Cold shock
SPS5912_RS09095	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SPS5912_RS09105	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SPS5912_RS09105	COG2111	Na H antiporter
SPS5912_RS09110	COG2111	Na H antiporter
SPS5912_RS09115	COG1006	Multisubunit Na H antiporter MnhC subunit
SPS5912_RS09120	COG0651	ATP synthesis coupled electron transport
SPS5912_RS09125	COG1863	multisubunit Na H antiporter MnhE subunit
SPS5912_RS09130	COG2212	antiporter activity
SPS5912_RS09135	COG1320	monovalent cation:proton antiporter activity
SPS5912_RS09145	COG2056	Na+-H+ antiporter family
SPS5912_RS09150	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SPS5912_RS09155	COG1252	NADH dehydrogenase
SPS5912_RS09160	COG0316	Belongs to the HesB IscA family
SPS5912_RS09165	COG4844	belongs to the
SPS5912_RS09170	COG1252	NADH dehydrogenase
SPS5912_RS09175	COG4837	Protein of unknown function (DUF1462)
SPS5912_RS09180	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SPS5912_RS09185	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SPS5912_RS09190	COG0647	UMP catabolic process
SPS5912_RS09195	COG2445	Protein of unknown function DUF86
SPS5912_RS09205	COG4470	Protein conserved in bacteria
SPS5912_RS09210	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SPS5912_RS09215	COG0737	Belongs to the 5'-nucleotidase family
SPS5912_RS09220	COG0730	response to heat
SPS5912_RS09225	COG1801	Protein of unknown function DUF72
SPS5912_RS09240	COG1253	flavin adenine dinucleotide binding
SPS5912_RS09250	COG0719	Fe-S assembly protein
SPS5912_RS09255	COG0822	iron-sulfur transferase activity
SPS5912_RS09265	COG0719	Fe-S assembly protein
SPS5912_RS09270	COG0396	ATPase activity
SPS5912_RS09280	COG1464	Belongs to the NlpA lipoprotein family
SPS5912_RS09285	COG1464	Belongs to the NlpA lipoprotein family
SPS5912_RS09290	COG2011	ABC-type metal ion transport system permease component
SPS5912_RS09295	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPS5912_RS09300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPS5912_RS09305	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SPS5912_RS09315	COG1393	Belongs to the ArsC family
SPS5912_RS09320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPS5912_RS09330	COG0710	3-dehydroquinate dehydratase activity
SPS5912_RS09340	COG1764	response to oxidative stress
SPS5912_RS09355	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPS5912_RS09375	COG0346	lactoylglutathione lyase activity
SPS5912_RS09405	COG0557	exoribonuclease II activity
SPS5912_RS09410	COG1647	Serine aminopeptidase, S33
SPS5912_RS09415	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SPS5912_RS09425	COG0148	phosphopyruvate hydratase activity
SPS5912_RS09430	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SPS5912_RS09435	COG0149	triose-phosphate isomerase activity
SPS5912_RS09440	COG0126	phosphoglycerate kinase activity
SPS5912_RS09465	COG1090	epimerase
SPS5912_RS09475	COG0740	serine-type endopeptidase activity
SPS5912_RS09490	COG1481	regulation of sporulation
SPS5912_RS09495	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SPS5912_RS09500	COG1660	Displays ATPase and GTPase activities
SPS5912_RS09515	COG0110	maltose O-acetyltransferase activity
SPS5912_RS09520	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SPS5912_RS09525	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SPS5912_RS09560	COG0653	protein targeting
SPS5912_RS09575	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SPS5912_RS09585	COG1739	Uncharacterized protein family UPF0029
SPS5912_RS09590	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SPS5912_RS09610	COG2195	Cleaves the N-terminal amino acid of tripeptides
SPS5912_RS09625	COG1929	Belongs to the glycerate kinase type-1 family
SPS5912_RS09630	COG3118	belongs to the thioredoxin family
SPS5912_RS09645	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SPS5912_RS09655	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPS5912_RS09660	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPS5912_RS09695	COG3104	oligopeptide transport
SPS5912_RS09700	COG3104	oligopeptide transport
SPS5912_RS09715	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SPS5912_RS09720	COG1174	glycine betaine transport
SPS5912_RS09725	COG1125	glycine betaine transport
SPS5912_RS09725	COG0517	IMP dehydrogenase activity
SPS5912_RS09730	COG0514	ATP-dependent DNA helicase (RecQ)
SPS5912_RS09735	COG0488	(ABC) transporter
SPS5912_RS09745	COG1368	sulfuric ester hydrolase activity
SPS5912_RS09755	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SPS5912_RS09775	COG0512	Glutamine amidotransferase of anthranilate synthase
SPS5912_RS09785	COG0720	synthase
SPS5912_RS09790	COG0602	queuosine metabolic process
SPS5912_RS09805	COG0463	Glycosyl transferase, family 2
SPS5912_RS09810	COG1253	flavin adenine dinucleotide binding
SPS5912_RS09815	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPS5912_RS09815	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPS5912_RS09815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPS5912_RS09820	COG1105	Belongs to the carbohydrate kinase PfkB family
SPS5912_RS09825	COG1349	DNA-binding transcription factor activity
SPS5912_RS09845	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SPS5912_RS09850	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SPS5912_RS09875	COG0039	L-malate dehydrogenase activity
SPS5912_RS09895	COG4989	oxidoreductase activity
SPS5912_RS09900	COG0523	cobalamin synthesis protein
SPS5912_RS09915	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SPS5912_RS09920	COG4988	ABC transporter
SPS5912_RS09925	COG1968	undecaprenyl-diphosphatase activity
SPS5912_RS09935	COG1671	Belongs to the UPF0178 family
SPS5912_RS09940	COG1611	Belongs to the LOG family
SPS5912_RS09970	COG2839	Protein conserved in bacteria
SPS5912_RS09975	COG2814	Major facilitator Superfamily
SPS5912_RS09980	COG0583	DNA-binding transcription factor activity
SPS5912_RS09995	COG0217	transcriptional regulatory protein
SPS5912_RS10000	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SPS5912_RS10005	COG2022	thiamine diphosphate biosynthetic process
SPS5912_RS10015	COG0352	thiamine-phosphate diphosphorylase activity
SPS5912_RS10025	COG3942	CHAP domain
SPS5912_RS10025	COG1388	LysM domain
SPS5912_RS10030	COG0306	phosphate transporter
SPS5912_RS10035	COG1392	Phosphate transport regulator
SPS5912_RS10040	COG0577	efflux transmembrane transporter activity
SPS5912_RS10045	COG1136	(ABC) transporter
SPS5912_RS10055	COG0745	RESPONSE REGULATOR receiver
SPS5912_RS10060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SPS5912_RS10065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPS5912_RS10075	COG3949	Membrane
SPS5912_RS10080	COG0477	Major facilitator Superfamily
SPS5912_RS10090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPS5912_RS10095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPS5912_RS10100	COG1120	ATPase activity
SPS5912_RS10105	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPS5912_RS10110	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SPS5912_RS10130	COG1132	(ABC) transporter
SPS5912_RS10135	COG1686	Belongs to the peptidase S11 family
SPS5912_RS10160	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SPS5912_RS10165	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SPS5912_RS10170	COG1682	transport, permease protein
SPS5912_RS10180	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
SPS5912_RS10185	COG0110	maltose O-acetyltransferase activity
SPS5912_RS10195	COG1475	DNA binding
SPS5912_RS10200	COG0019	diaminopimelate decarboxylase activity
SPS5912_RS10210	COG4264	IucA IucC family
SPS5912_RS10215	COG4264	IucA IucC family
SPS5912_RS10220	COG2814	Major facilitator Superfamily
SPS5912_RS10225	COG4264	IucA IucC family
SPS5912_RS10230	COG2423	ornithine cyclodeaminase activity
SPS5912_RS10240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SPS5912_RS10245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPS5912_RS10250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPS5912_RS10260	COG1121	(ABC) transporter
SPS5912_RS10265	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPS5912_RS10270	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPS5912_RS10275	COG1320	monovalent cation:proton antiporter activity
SPS5912_RS10280	COG2212	antiporter activity
SPS5912_RS10285	COG1863	multisubunit Na H antiporter MnhE subunit
SPS5912_RS10295	COG1006	Multisubunit Na H antiporter MnhC subunit
SPS5912_RS10300	COG2111	Na H antiporter
SPS5912_RS10305	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SPS5912_RS10305	COG2111	Na H antiporter
SPS5912_RS10355	COG0546	phosphoglycolate phosphatase activity
SPS5912_RS10360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPS5912_RS10365	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SPS5912_RS10370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SPS5912_RS10375	COG0805	protein transport
SPS5912_RS10380	COG0018	arginyl-trna synthetase
SPS5912_RS10395	COG1078	dGTPase activity
SPS5912_RS10405	COG4844	belongs to the
SPS5912_RS10465	COG0471	metal ion transport
SPS5912_RS10500	COG0095	Lipoate-protein ligase
SPS5912_RS10525	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPS5912_RS10530	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SPS5912_RS10540	COG2814	Major facilitator Superfamily
SPS5912_RS10545	COG1566	PFAM secretion protein HlyD family protein
SPS5912_RS10555	COG2311	Membrane
SPS5912_RS10570	COG2363	Small membrane protein
SPS5912_RS10600	COG0183	Belongs to the thiolase family
SPS5912_RS10605	COG0318	PFAM AMP-dependent synthetase and ligase
SPS5912_RS10610	COG0588	phosphoglycerate mutase activity
SPS5912_RS10615	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SPS5912_RS10625	COG2814	Major facilitator Superfamily
SPS5912_RS10640	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SPS5912_RS10650	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
SPS5912_RS10665	COG2190	(PTS) system
SPS5912_RS10665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPS5912_RS10665	COG1263	PTS System
SPS5912_RS10680	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SPS5912_RS10685	COG1469	GTP cyclohydrolase I activity
SPS5912_RS10690	COG1136	(ABC) transporter
SPS5912_RS10690	COG0577	efflux transmembrane transporter activity
SPS5912_RS10705	COG0561	phosphatase activity
SPS5912_RS10715	COG1428	Deoxynucleoside kinase
SPS5912_RS10720	COG1428	Deoxynucleoside kinase
SPS5912_RS10725	COG0546	phosphoglycolate phosphatase activity
SPS5912_RS10755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SPS5912_RS10765	COG1473	amidohydrolase
SPS5912_RS10770	COG3527	Alpha-acetolactate decarboxylase
SPS5912_RS10775	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SPS5912_RS10780	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SPS5912_RS10785	COG0049	tRNA binding
SPS5912_RS10790	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SPS5912_RS10800	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SPS5912_RS10805	COG0085	RNA polymerase activity
SPS5912_RS10810	COG2813	Specifically methylates the guanine in position
SPS5912_RS10820	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SPS5912_RS10825	COG0081	regulation of translation
SPS5912_RS10830	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SPS5912_RS10835	COG0250	Participates in transcription elongation, termination and antitermination
SPS5912_RS10840	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SPS5912_RS10845	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SPS5912_RS10865	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SPS5912_RS10870	COG0215	cysteine-tRNA ligase activity
SPS5912_RS10875	COG1045	serine acetyltransferase
SPS5912_RS10880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SPS5912_RS10890	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SPS5912_RS10895	COG4956	integral membrane protein (PIN domain superfamily)
SPS5912_RS10900	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SPS5912_RS10935	COG0542	response to heat
SPS5912_RS10940	COG3869	Catalyzes the specific phosphorylation of arginine residues in
SPS5912_RS10945	COG3880	PFAM UvrB UvrC protein
SPS5912_RS10955	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SPS5912_RS10965	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SPS5912_RS10970	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SPS5912_RS10975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPS5912_RS10980	COG1289	transmembrane transporter activity
SPS5912_RS11070	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPS5912_RS11075	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SPS5912_RS11085	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SPS5912_RS11095	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SPS5912_RS11100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPS5912_RS11115	COG1098	S1 RNA binding domain
SPS5912_RS11125	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPS5912_RS11130	COG3956	TIGRFAM MazG family protein
SPS5912_RS11135	COG2244	polysaccharide biosynthetic process
SPS5912_RS11140	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPS5912_RS11145	COG0193	aminoacyl-tRNA hydrolase activity
SPS5912_RS11155	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPS5912_RS11160	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SPS5912_RS11165	COG2088	sporulation resulting in formation of a cellular spore
SPS5912_RS11170	COG0251	oxidation-reduction process
SPS5912_RS11175	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPS5912_RS11180	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SPS5912_RS11185	COG4466	Protein conserved in bacteria
SPS5912_RS11195	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SPS5912_RS11200	COG0084	hydrolase, TatD family'
SPS5912_RS11210	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SPS5912_RS11215	COG2827	Endonuclease containing a URI domain
SPS5912_RS11220	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SPS5912_RS11225	COG4467	Involved in initiation control of chromosome replication
SPS5912_RS11230	COG1774	PSP1 C-terminal conserved region
SPS5912_RS11235	COG0470	DNA polymerase III
SPS5912_RS11240	COG3870	Protein conserved in bacteria
SPS5912_RS11245	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SPS5912_RS11250	COG1982	Orn Lys Arg decarboxylase major
SPS5912_RS11275	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SPS5912_RS11280	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SPS5912_RS11285	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPS5912_RS11290	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SPS5912_RS11300	COG2188	Transcriptional regulator
SPS5912_RS11305	COG0366	Alpha amylase catalytic
SPS5912_RS11310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPS5912_RS11310	COG1263	PTS System
SPS5912_RS11320	COG0493	'glutamate synthase
SPS5912_RS11325	COG0067	glutamate synthase
SPS5912_RS11325	COG0069	glutamate synthase activity
SPS5912_RS11325	COG0070	glutamate synthase
SPS5912_RS11330	COG0583	DNA-binding transcription factor activity
SPS5912_RS11345	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SPS5912_RS11370	COG0626	cystathionine gamma-synthase activity
SPS5912_RS11375	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SPS5912_RS11380	COG2272	Belongs to the type-B carboxylesterase lipase family
SPS5912_RS11385	COG0733	neurotransmitter:sodium symporter activity
SPS5912_RS11400	COG0745	RESPONSE REGULATOR receiver
SPS5912_RS11405	COG2205	protein histidine kinase activity
SPS5912_RS11415	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SPS5912_RS11420	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SPS5912_RS11445	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SPS5912_RS11450	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SPS5912_RS11450	COG0574	Belongs to the PEP-utilizing enzyme family
SPS5912_RS11470	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
SPS5912_RS11480	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SPS5912_RS11490	COG1486	melibiose metabolic process
SPS5912_RS11495	COG1263	PTS System
SPS5912_RS11495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPS5912_RS11515	COG2210	Belongs to the sulfur carrier protein TusA family
SPS5912_RS11520	COG1937	Protein conserved in bacteria
SPS5912_RS11525	COG0730	response to heat
SPS5912_RS11530	COG2814	Major facilitator Superfamily
SPS5912_RS11545	COG1124	(ABC) transporter
SPS5912_RS11550	COG0444	Belongs to the ABC transporter superfamily
SPS5912_RS11555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPS5912_RS11560	COG0601	transmembrane transport
SPS5912_RS11565	COG0747	negative chemotaxis
SPS5912_RS11590	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPS5912_RS11610	COG1525	nuclease
SPS5912_RS11635	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SPS5912_RS11635	COG0519	Catalyzes the synthesis of GMP from XMP
SPS5912_RS11640	COG0516	GMP reductase activity
SPS5912_RS11640	COG0517	IMP dehydrogenase activity
SPS5912_RS11645	COG2233	PERMEase
SPS5912_RS11650	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPS5912_RS11665	COG5183	chlorophyll binding
SPS5912_RS11670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPS5912_RS11675	COG1823	symporter activity
SPS5912_RS11680	COG1136	(ABC) transporter
SPS5912_RS11680	COG0577	efflux transmembrane transporter activity
SPS5912_RS11695	COG0778	Nitroreductase
SPS5912_RS11700	COG0450	alkyl hydroperoxide reductase
SPS5912_RS11715	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SPS5912_RS11725	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPS5912_RS11730	COG2011	ABC-type metal ion transport system permease component
SPS5912_RS11735	COG1464	Belongs to the NlpA lipoprotein family
SPS5912_RS11740	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SPS5912_RS11745	COG0753	catalase activity
SPS5912_RS11755	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SPS5912_RS11765	COG0360	Binds together with S18 to 16S ribosomal RNA
SPS5912_RS11775	COG1668	transmembrane transport
SPS5912_RS11780	COG1131	(ABC) transporter
SPS5912_RS11785	COG0012	GTP binding
SPS5912_RS11790	COG4481	Protein conserved in bacteria
SPS5912_RS11795	COG0668	transmembrane transport
SPS5912_RS11800	COG1475	DNA binding
SPS5912_RS11805	COG0626	cystathionine gamma-synthase activity
SPS5912_RS11810	COG0626	cystathionine gamma-synthase activity
SPS5912_RS11815	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SPS5912_RS11815	COG0646	methionine synthase
SPS5912_RS11825	COG0829	nickel cation binding
SPS5912_RS11835	COG0830	nickel cation binding
SPS5912_RS11840	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SPS5912_RS11850	COG2388	GCN5-related N-acetyl-transferase
SPS5912_RS11855	COG1846	Transcriptional regulator
SPS5912_RS11860	COG0346	lactoylglutathione lyase activity
SPS5912_RS11865	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SPS5912_RS11870	COG0400	carboxylic ester hydrolase activity
SPS5912_RS11895	COG0357	Ribosomal RNA small subunit methyltransferase G
SPS5912_RS11900	COG0445	tRNA wobble uridine modification
SPS5912_RS11905	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SPS5912_RS11910	COG0594	ribonuclease P activity