locus-tag	class	description
DNI88_RS00065	COG1674	ftsk spoiiie
DNI88_RS00070	COG0433	COG0433 Predicted ATPase
DNI88_RS00090	COG2946	Replication initiation factor
DNI88_RS00120	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DNI88_RS00125	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DNI88_RS00130	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DNI88_RS00135	COG0477	Major facilitator Superfamily
DNI88_RS00140	COG2211	Major facilitator Superfamily
DNI88_RS00145	COG3250	beta-galactosidase activity
DNI88_RS00150	COG1957	nucleoside hydrolase
DNI88_RS00185	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DNI88_RS00190	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
DNI88_RS00195	COG2807	transmembrane transport
DNI88_RS00200	COG1396	sequence-specific DNA binding
DNI88_RS00215	COG1785	Belongs to the alkaline phosphatase family
DNI88_RS00220	COG0494	nUDIX hydrolase
DNI88_RS00225	COG0556	nucleotide-excision repair
DNI88_RS00240	COG1510	regulation of RNA biosynthetic process
DNI88_RS00245	COG1012	belongs to the aldehyde dehydrogenase family
DNI88_RS00250	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DNI88_RS00255	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DNI88_RS00265	COG0107	imidazoleglycerol-phosphate synthase activity
DNI88_RS00270	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DNI88_RS00285	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DNI88_RS00290	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DNI88_RS00295	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DNI88_RS00300	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DNI88_RS00335	COG2376	Dihydroxyacetone kinase
DNI88_RS00340	COG1461	Dihydroxyacetone kinase
DNI88_RS00345	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
DNI88_RS00350	COG2824	Alkylphosphonate utilization operon protein PhnA
DNI88_RS00355	COG1012	belongs to the aldehyde dehydrogenase family
DNI88_RS00370	COG0596	Alpha beta hydrolase
DNI88_RS00375	COG0789	Transcriptional regulator
DNI88_RS00380	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DNI88_RS00380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DNI88_RS00380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DNI88_RS00390	COG3942	CHAP domain
DNI88_RS00390	COG1705	Flagellar rod assembly protein muramidase FlgJ
DNI88_RS00400	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DNI88_RS00405	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DNI88_RS00410	COG0747	negative chemotaxis
DNI88_RS00435	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DNI88_RS00435	COG0463	Glycosyl transferase, family 2
DNI88_RS00440	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DNI88_RS00440	COG0463	Glycosyl transferase, family 2
DNI88_RS00445	COG0438	transferase activity, transferring glycosyl groups
DNI88_RS00450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DNI88_RS00455	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DNI88_RS00475	COG3181	Tripartite tricarboxylate transporter family receptor
DNI88_RS00480	COG0778	Nitroreductase
DNI88_RS00485	COG3001	Fructosamine kinase
DNI88_RS00510	COG1136	(ABC) transporter
DNI88_RS00515	COG0577	efflux transmembrane transporter activity
DNI88_RS00535	COG4413	Urea transporter
DNI88_RS00545	COG0832	Belongs to the urease beta subunit family
DNI88_RS00550	COG0804	urea catabolic process
DNI88_RS00555	COG0717	Belongs to the dCTP deaminase family
DNI88_RS00560	COG0523	cobalamin synthesis protein
DNI88_RS00570	COG1141	Ferredoxin
DNI88_RS00595	COG0583	DNA-binding transcription factor activity
DNI88_RS00605	COG1346	cytolysis
DNI88_RS00620	COG1846	Transcriptional regulator
DNI88_RS00625	COG0778	Nitroreductase
DNI88_RS00630	COG2357	RelA SpoT domain protein
DNI88_RS00670	COG1028	Short-chain dehydrogenase reductase Sdr
DNI88_RS00685	COG3835	regulator
DNI88_RS00690	COG2855	membrane
DNI88_RS00695	COG3961	Belongs to the TPP enzyme family
DNI88_RS00700	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DNI88_RS00705	COG0512	Glutamine amidotransferase of anthranilate synthase
DNI88_RS00715	COG0134	indole-3-glycerol-phosphate synthase activity
DNI88_RS00725	COG0133	tryptophan synthase activity
DNI88_RS00730	COG0159	tryptophan synthase activity
DNI88_RS00750	COG0277	FAD linked oxidase domain protein
DNI88_RS00755	COG0247	lactate metabolic process
DNI88_RS00760	COG1132	(ABC) transporter
DNI88_RS00765	COG1132	(ABC) transporter
DNI88_RS00770	COG0789	Transcriptional regulator
DNI88_RS00770	COG4978	Transcriptional regulator
DNI88_RS00775	COG3871	stress protein (general stress protein 26)
DNI88_RS00780	COG1115	amino acid carrier protein
DNI88_RS00785	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
DNI88_RS00790	COG2814	Major facilitator Superfamily
DNI88_RS00795	COG2271	Major facilitator Superfamily
DNI88_RS00800	COG3764	Sortase (surface protein transpeptidase)
DNI88_RS00805	COG1929	Belongs to the glycerate kinase type-1 family
DNI88_RS00815	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
DNI88_RS00835	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DNI88_RS00840	COG0702	epimerase
DNI88_RS00845	COG4166	transmembrane transport
DNI88_RS00850	COG0444	Belongs to the ABC transporter superfamily
DNI88_RS00855	COG4608	Belongs to the ABC transporter superfamily
DNI88_RS00860	COG0601	transmembrane transport
DNI88_RS00865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DNI88_RS00870	COG4166	transmembrane transport
DNI88_RS00875	COG0444	Belongs to the ABC transporter superfamily
DNI88_RS00880	COG4608	Belongs to the ABC transporter superfamily
DNI88_RS00885	COG0601	transmembrane transport
DNI88_RS00890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DNI88_RS00900	COG1760	l-serine dehydratase
DNI88_RS00905	COG1760	l-serine dehydratase
DNI88_RS00935	COG0471	metal ion transport
DNI88_RS00940	COG2116	formate transmembrane transporter activity
DNI88_RS00945	COG0454	-acetyltransferase
DNI88_RS00955	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DNI88_RS00955	COG1648	precorrin-2 dehydrogenase activity
DNI88_RS00960	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DNI88_RS00965	COG2146	nitrite reductase [NAD(P)H] activity
DNI88_RS00970	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DNI88_RS00970	COG1648	precorrin-2 dehydrogenase activity
DNI88_RS00975	COG0737	Belongs to the 5'-nucleotidase family
DNI88_RS00985	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DNI88_RS00990	COG1140	nitrate reductase beta subunit
DNI88_RS01000	COG2181	nitrate reductase activity
DNI88_RS01010	COG4585	Histidine kinase
DNI88_RS01015	COG2197	response regulator
DNI88_RS01020	COG2223	nitrite transmembrane transporter activity
DNI88_RS01030	COG4187	Peptidase family M20/M25/M40
DNI88_RS01040	COG0039	L-malate dehydrogenase activity
DNI88_RS01045	COG1363	Peptidase, m42
DNI88_RS01050	COG0697	spore germination
DNI88_RS01060	COG2807	transmembrane transport
DNI88_RS01070	COG1263	PTS System
DNI88_RS01070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DNI88_RS01085	COG1283	sodium-dependent phosphate transmembrane transporter activity
DNI88_RS01105	COG0492	ferredoxin-NADP+ reductase activity
DNI88_RS01110	COG2814	Major facilitator Superfamily
DNI88_RS01115	COG0604	alcohol dehydrogenase
DNI88_RS01130	COG1620	l-lactate permease
DNI88_RS01135	COG0438	transferase activity, transferring glycosyl groups
DNI88_RS01140	COG0579	oxidoreductase
DNI88_RS01155	COG0577	efflux transmembrane transporter activity
DNI88_RS01190	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DNI88_RS01200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DNI88_RS01220	COG1304	FMN binding
DNI88_RS01225	COG0523	cobalamin synthesis protein
DNI88_RS01230	COG0786	glutamate:sodium symporter activity
DNI88_RS01235	COG2207	Transcriptional regulator
DNI88_RS01240	COG3250	beta-galactosidase activity
DNI88_RS01260	COG1757	Na H antiporter
DNI88_RS01265	COG2094	Belongs to the DNA glycosylase MPG family
DNI88_RS01270	COG3152	Membrane
DNI88_RS01275	COG4152	abc transporter atp-binding protein
DNI88_RS01280	COG1668	transmembrane transport
DNI88_RS01285	COG1742	UPF0060 membrane protein
DNI88_RS01290	COG2017	converts alpha-aldose to the beta-anomer
DNI88_RS01295	COG2258	MOSC domain
DNI88_RS01300	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DNI88_RS01310	COG1266	CAAX protease self-immunity
DNI88_RS01315	COG0583	DNA-binding transcription factor activity
DNI88_RS01320	COG3314	Sporulation integral membrane protein YlbJ
DNI88_RS01325	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DNI88_RS01330	COG1228	amidohydrolase
DNI88_RS01335	COG0659	secondary active sulfate transmembrane transporter activity
DNI88_RS01360	COG0385	Bile acid
DNI88_RS01370	COG0346	lactoylglutathione lyase activity
DNI88_RS01375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DNI88_RS01400	COG1113	amino acid transport
DNI88_RS01425	COG1316	TRANSCRIPTIONal
DNI88_RS01440	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DNI88_RS01445	COG3383	formate dehydrogenase (NAD+) activity
DNI88_RS01470	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DNI88_RS01475	COG2076	Multidrug Resistance protein
DNI88_RS01480	COG2076	Multidrug Resistance protein
DNI88_RS01485	COG3942	CHAP domain
DNI88_RS01495	COG1757	Na H antiporter
DNI88_RS01505	COG3942	CHAP domain
DNI88_RS01525	COG1960	acyl-CoA dehydrogenase activity
DNI88_RS01530	COG2832	Protein of unknown function (DUF454)
DNI88_RS01535	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DNI88_RS01540	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DNI88_RS01550	COG2186	Transcriptional regulator
DNI88_RS01560	COG1268	BioY protein
DNI88_RS01575	COG1609	Transcriptional regulator
DNI88_RS01580	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DNI88_RS01585	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DNI88_RS01590	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
DNI88_RS01600	COG4149	molybdate abc transporter
DNI88_RS01605	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DNI88_RS01610	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DNI88_RS01640	COG0314	molybdopterin synthase activity
DNI88_RS01650	COG0746	molybdenum cofactor guanylyltransferase activity
DNI88_RS01680	COG2348	transferase activity, transferring amino-acyl groups
DNI88_RS01685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DNI88_RS01690	COG0436	Aminotransferase
DNI88_RS01725	COG2252	PERMEase
DNI88_RS01745	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DNI88_RS01750	COG0088	Forms part of the polypeptide exit tunnel
DNI88_RS01755	COG0089	rRNA binding
DNI88_RS01760	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DNI88_RS01765	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DNI88_RS01770	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DNI88_RS01775	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DNI88_RS01780	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DNI88_RS01785	COG0255	Belongs to the universal ribosomal protein uL29 family
DNI88_RS01795	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DNI88_RS01810	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DNI88_RS01815	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DNI88_RS01820	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DNI88_RS01830	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DNI88_RS01835	COG1841	ribosomal large subunit assembly
DNI88_RS01845	COG0201	protein transport
DNI88_RS01860	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DNI88_RS01870	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DNI88_RS01875	COG0202	RNA polymerase activity
DNI88_RS01880	COG0203	ribosomal protein L17
DNI88_RS01885	COG1122	ATPase activity
DNI88_RS01890	COG1122	ATPase activity
DNI88_RS01900	COG0101	tRNA pseudouridine synthase activity
DNI88_RS01905	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DNI88_RS01925	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DNI88_RS01990	COG3684	Belongs to the aldolase LacD family
DNI88_RS02000	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DNI88_RS02000	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DNI88_RS02010	COG0488	(ABC) transporter
DNI88_RS02015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DNI88_RS02025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DNI88_RS02040	COG1302	Protein conserved in bacteria
DNI88_RS02045	COG2814	Major facilitator Superfamily
DNI88_RS02050	COG4264	IucA IucC family
DNI88_RS02055	COG2814	Major facilitator Superfamily
DNI88_RS02060	COG4264	IucA IucC family
DNI88_RS02065	COG3457	Alanine racemase
DNI88_RS02070	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DNI88_RS02075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DNI88_RS02080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DNI88_RS02085	COG3314	Sporulation integral membrane protein YlbJ
DNI88_RS02095	COG1988	membrane-bound metal-dependent
DNI88_RS02100	COG4284	Utp--glucose-1-phosphate uridylyltransferase
DNI88_RS02105	COG1272	protein, Hemolysin III
DNI88_RS02125	COG2814	Major facilitator Superfamily
DNI88_RS02130	COG0489	protein tyrosine kinase activity
DNI88_RS02195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DNI88_RS02210	COG3711	transcriptional antiterminator
DNI88_RS02240	COG1119	ATPase activity
DNI88_RS02245	COG0561	phosphatase activity
DNI88_RS02255	COG2186	Transcriptional regulator
DNI88_RS02260	COG1482	cell wall glycoprotein biosynthetic process
DNI88_RS02275	COG1757	Na H antiporter
DNI88_RS02285	COG0813	purine-nucleoside phosphorylase activity
DNI88_RS02320	COG5146	pantothenate kinase activity
DNI88_RS02335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DNI88_RS02340	COG3343	RNA polymerase activity
DNI88_RS02345	COG0504	CTP synthase activity
DNI88_RS02350	COG2271	Major facilitator Superfamily
DNI88_RS02355	COG4821	SIS domain
DNI88_RS02360	COG0191	fructose-bisphosphate aldolase activity
DNI88_RS02365	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DNI88_RS02370	COG1733	regulation of RNA biosynthetic process
DNI88_RS02380	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DNI88_RS02385	COG0254	rRNA binding
DNI88_RS02395	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DNI88_RS02400	COG2890	protein-(glutamine-N5) methyltransferase activity
DNI88_RS02405	COG0009	L-threonylcarbamoyladenylate synthase
DNI88_RS02410	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DNI88_RS02415	COG4475	Protein of unknown function (DUF436)
DNI88_RS02420	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DNI88_RS02425	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DNI88_RS02430	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DNI88_RS02440	COG0356	it plays a direct role in the translocation of protons across the membrane
DNI88_RS02445	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DNI88_RS02455	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DNI88_RS02465	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DNI88_RS02495	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DNI88_RS02510	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DNI88_RS02520	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DNI88_RS02525	COG0352	thiamine-phosphate diphosphorylase activity
DNI88_RS02530	COG0706	membrane insertase activity
DNI88_RS02535	COG1418	mRNA catabolic process
DNI88_RS02540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DNI88_RS02545	COG1937	Protein conserved in bacteria
DNI88_RS02560	COG2217	Heavy metal translocating P-type atpase
DNI88_RS02575	COG0772	Belongs to the SEDS family
DNI88_RS02580	COG1181	Belongs to the D-alanine--D-alanine ligase family
DNI88_RS02585	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DNI88_RS02590	COG0513	Belongs to the DEAD box helicase family
DNI88_RS02605	COG3402	PFAM membrane-flanked domain
DNI88_RS02610	COG0736	holo-[acyl-carrier-protein] synthase activity
DNI88_RS02615	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DNI88_RS02625	COG2337	Toxic component of a toxin-antitoxin (TA) module
DNI88_RS02630	COG2208	phosphoserine phosphatase activity
DNI88_RS02635	COG1366	Belongs to the anti-sigma-factor antagonist family
DNI88_RS02645	COG1191	sigma factor activity
DNI88_RS02650	COG2183	response to ionizing radiation
DNI88_RS02655	COG3091	SprT-like family
DNI88_RS02715	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DNI88_RS02725	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DNI88_RS02730	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DNI88_RS02740	COG0028	Belongs to the TPP enzyme family
DNI88_RS02745	COG0129	dihydroxy-acid dehydratase activity
DNI88_RS02750	COG0802	atpase or kinase
DNI88_RS02755	COG1214	PFAM Peptidase M22, glycoprotease
DNI88_RS02760	COG0456	acetyltransferase
DNI88_RS02765	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DNI88_RS02770	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DNI88_RS02775	COG0488	(ABC) transporter
DNI88_RS02780	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DNI88_RS02785	COG2814	Major facilitator Superfamily
DNI88_RS02790	COG1846	Transcriptional regulator
DNI88_RS02800	COG2124	cytochrome p450
DNI88_RS02810	COG1609	Transcriptional regulator
DNI88_RS02815	COG1621	beta-fructofuranosidase activity
DNI88_RS02820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DNI88_RS02840	COG4512	PFAM Accessory gene regulator B
DNI88_RS02885	COG1404	Belongs to the peptidase S8 family
DNI88_RS02890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DNI88_RS02895	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DNI88_RS02915	COG1131	(ABC) transporter
DNI88_RS02930	COG1070	Carbohydrate kinase
DNI88_RS02935	COG2610	gluconate transmembrane transporter activity
DNI88_RS02970	COG2706	6-phosphogluconolactonase activity
DNI88_RS02975	COG1012	belongs to the aldehyde dehydrogenase family
DNI88_RS02985	COG1227	inorganic diphosphatase activity
DNI88_RS02990	COG1335	isochorismatase
DNI88_RS03000	COG0077	Prephenate dehydratase
DNI88_RS03010	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DNI88_RS03020	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
DNI88_RS03030	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DNI88_RS03035	COG4496	protein, YerC YecD
DNI88_RS03040	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
DNI88_RS03045	COG0210	DNA helicase
DNI88_RS03050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DNI88_RS03055	COG4851	CamS sex pheromone cAM373 precursor
DNI88_RS03060	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DNI88_RS03065	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DNI88_RS03075	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DNI88_RS03080	COG1597	lipid kinase activity
DNI88_RS03090	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DNI88_RS03105	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DNI88_RS03115	COG1528	Iron-storage protein
DNI88_RS03130	COG4129	membrane
DNI88_RS03135	COG0024	Methionine aminopeptidase
DNI88_RS03160	COG0288	reversible hydration of carbon dioxide
DNI88_RS03165	COG1295	ribonuclease BN
DNI88_RS03180	COG4840	Belongs to the UPF0435 family
DNI88_RS03185	COG2309	aminopeptidase activity
DNI88_RS03190	COG1607	acyl-coa hydrolase
DNI88_RS03195	COG0535	radical SAM domain protein
DNI88_RS03205	COG0693	protein deglycase activity
DNI88_RS03210	COG0028	Belongs to the TPP enzyme family
DNI88_RS03215	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DNI88_RS03220	COG2137	regulation of response to DNA damage stimulus
DNI88_RS03230	COG1134	teichoic acid transport
DNI88_RS03230	COG1388	LysM domain
DNI88_RS03240	COG1988	membrane-bound metal-dependent
DNI88_RS03245	COG1194	a g-specific adenine glycosylase
DNI88_RS03250	COG3557	Belongs to the UPF0374 family
DNI88_RS03265	COG4129	membrane
DNI88_RS03270	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DNI88_RS03275	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DNI88_RS03285	COG0735	belongs to the Fur family
DNI88_RS03510	COG0765	amino acid transport
DNI88_RS03515	COG1126	abc transporter atp-binding protein
DNI88_RS03520	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DNI88_RS03530	COG0363	glucosamine-6-phosphate deaminase activity
DNI88_RS03545	COG0114	fumarate hydratase activity
DNI88_RS03550	COG0248	Ppx GppA phosphatase
DNI88_RS03555	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DNI88_RS03560	COG0564	pseudouridine synthase activity
DNI88_RS03565	COG2203	Gaf domain
DNI88_RS03565	COG4585	Histidine kinase
DNI88_RS03570	COG2197	response regulator
DNI88_RS03580	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DNI88_RS03590	COG4399	Belongs to the UPF0754 family
DNI88_RS03595	COG3679	Belongs to the UPF0342 family
DNI88_RS03600	COG0420	3'-5' exonuclease activity
DNI88_RS03610	COG3481	metal-dependent phosphohydrolase, HD sub domain
DNI88_RS03615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DNI88_RS03630	COG1846	Transcriptional regulator
DNI88_RS03640	COG0537	adenosine 5'-monophosphoramidase activity
DNI88_RS03645	COG1131	(ABC) transporter
DNI88_RS03650	COG4473	ABC transporter
DNI88_RS03665	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DNI88_RS03675	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DNI88_RS03680	COG3545	Serine hydrolase
DNI88_RS03745	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DNI88_RS03845	COG1484	DNA-dependent DNA replication
DNI88_RS04015	COG0739	heme binding
DNI88_RS04115	COG3037	sugar-specific permease SgaT UlaA
DNI88_RS04135	COG3623	hexulose-6-phosphate isomerase
DNI88_RS04140	COG0235	Class ii aldolase
DNI88_RS04160	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DNI88_RS04165	COG0494	nUDIX hydrolase
DNI88_RS04170	COG1506	peptidase
DNI88_RS04175	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DNI88_RS04180	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DNI88_RS04190	COG0656	L-ascorbic acid biosynthetic process
DNI88_RS04195	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DNI88_RS04200	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DNI88_RS04210	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DNI88_RS04235	COG3266	domain, Protein
DNI88_RS04235	COG4193	domain, Protein
DNI88_RS04235	COG5632	N-Acetylmuramoyl-L-alanine amidase
DNI88_RS04245	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DNI88_RS04245	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DNI88_RS04250	COG0307	riboflavin synthase, alpha
DNI88_RS04255	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DNI88_RS04255	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DNI88_RS04260	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DNI88_RS04275	COG2267	carboxylic ester hydrolase activity
DNI88_RS04280	COG0039	L-malate dehydrogenase activity
DNI88_RS04290	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DNI88_RS04295	COG1242	4 iron, 4 sulfur cluster binding
DNI88_RS04300	COG2814	Major facilitator Superfamily
DNI88_RS04305	COG0495	leucyl-tRNA aminoacylation
DNI88_RS04310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DNI88_RS04315	COG2081	HI0933 family
DNI88_RS04320	COG2244	polysaccharide biosynthetic process
DNI88_RS04325	COG1187	pseudouridine synthase activity
DNI88_RS04335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DNI88_RS04340	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DNI88_RS04345	COG0510	thiamine kinase activity
DNI88_RS04350	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DNI88_RS04355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DNI88_RS04365	COG1363	Peptidase, m42
DNI88_RS04370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DNI88_RS04375	COG4848	Belongs to the UPF0354 family
DNI88_RS04380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DNI88_RS04385	COG1674	ftsk spoiiie
DNI88_RS04390	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DNI88_RS04395	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
DNI88_RS04405	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DNI88_RS04405	COG1605	Chorismate mutase
DNI88_RS04410	COG1609	Transcriptional regulator
DNI88_RS04420	COG0454	-acetyltransferase
DNI88_RS04425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DNI88_RS04430	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DNI88_RS04435	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DNI88_RS04445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DNI88_RS04450	COG0204	Acyl-transferase
DNI88_RS04460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DNI88_RS04465	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DNI88_RS04470	COG1764	response to oxidative stress
DNI88_RS04505	COG0456	acetyltransferase
DNI88_RS04540	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DNI88_RS04545	COG1956	GAF domain-containing protein
DNI88_RS04550	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
DNI88_RS04555	COG1104	cysteine desulfurase activity
DNI88_RS04560	COG0301	tRNA thio-modification
DNI88_RS04570	COG0616	signal peptide processing
DNI88_RS04575	COG1714	RDD family
DNI88_RS04580	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DNI88_RS04585	COG0827	DNA restriction-modification system
DNI88_RS04590	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DNI88_RS04595	COG0589	response to stress
DNI88_RS04600	COG0686	Belongs to the AlaDH PNT family
DNI88_RS04610	COG0006	proline dipeptidase activity
DNI88_RS04615	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DNI88_RS04625	COG4109	DRTGG domain
DNI88_RS04630	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DNI88_RS04635	COG0587	DNA-directed DNA polymerase activity
DNI88_RS04640	COG0281	malic enzyme
DNI88_RS04645	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DNI88_RS04650	COG0825	malonyl-CoA metabolic process
DNI88_RS04655	COG0205	6-phosphofructokinase activity
DNI88_RS04660	COG0469	pyruvate kinase activity
DNI88_RS04665	COG0372	Belongs to the citrate synthase family
DNI88_RS04670	COG0538	isocitrate dehydrogenase activity
DNI88_RS04675	COG0745	RESPONSE REGULATOR receiver
DNI88_RS04680	COG5002	protein histidine kinase activity
DNI88_RS04685	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DNI88_RS04685	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DNI88_RS04695	COG0237	dephospho-CoA kinase activity
DNI88_RS04710	COG3611	Membrane attachment protein
DNI88_RS04715	COG1484	DNA-dependent DNA replication
DNI88_RS04725	COG0833	amino acid
DNI88_RS04735	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DNI88_RS04740	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DNI88_RS04745	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DNI88_RS04760	COG0544	peptidyl-prolyl cis-trans isomerase activity
DNI88_RS04770	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DNI88_RS04775	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DNI88_RS04785	COG0181	hydroxymethylbilane synthase activity
DNI88_RS04800	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DNI88_RS04810	COG2818	Glycosylase
DNI88_RS04815	COG0525	valine-tRNA ligase activity
DNI88_RS04820	COG0285	dihydrofolate synthase activity
DNI88_RS04830	COG2003	Belongs to the UPF0758 family
DNI88_RS04865	COG2868	ribosomal protein
DNI88_RS04875	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DNI88_RS04885	COG0632	four-way junction helicase activity
DNI88_RS04895	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DNI88_RS04905	COG1862	Preprotein translocase
DNI88_RS04910	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DNI88_RS04910	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DNI88_RS04915	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DNI88_RS04915	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DNI88_RS04920	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DNI88_RS04930	COG1490	D-aminoacyl-tRNA deacylase activity
DNI88_RS04935	COG0860	N-Acetylmuramoyl-L-alanine amidase
DNI88_RS04945	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DNI88_RS04955	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DNI88_RS04960	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DNI88_RS04965	COG1959	2 iron, 2 sulfur cluster binding
DNI88_RS04985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DNI88_RS04990	COG1104	cysteine desulfurase activity
DNI88_RS04995	COG0482	sulfurtransferase activity
DNI88_RS05005	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DNI88_RS05010	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DNI88_RS05015	COG4472	Bacterial protein of unknown function (DUF965)
DNI88_RS05020	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DNI88_RS05025	COG3906	Belongs to the UPF0473 family
DNI88_RS05030	COG4122	O-methyltransferase activity
DNI88_RS05035	COG0826	peptidase U32
DNI88_RS05040	COG0826	peptidase U32
DNI88_RS05045	COG0572	uridine kinase
DNI88_RS05055	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DNI88_RS05060	COG1984	allophanate hydrolase subunit 2
DNI88_RS05065	COG0511	ligase activity, forming carbon-carbon bonds
DNI88_RS05070	COG0439	Biotin carboxylase
DNI88_RS05075	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DNI88_RS05080	COG1914	H( )-stimulated, divalent metal cation uptake system
DNI88_RS05085	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DNI88_RS05090	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DNI88_RS05095	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DNI88_RS05100	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DNI88_RS05105	COG1534	Rna-binding protein
DNI88_RS05115	COG1713	HD superfamily hydrolase involved in NAD metabolism
DNI88_RS05120	COG0799	negative regulation of ribosome biogenesis
DNI88_RS05125	COG2226	methyltransferase
DNI88_RS05130	COG1555	photosystem II stabilization
DNI88_RS05130	COG1596	polysaccharide export
DNI88_RS05135	COG2131	deaminase
DNI88_RS05140	COG2333	competence protein COMEC
DNI88_RS05140	COG0658	competence protein
DNI88_RS05145	COG1466	dna polymerase III delta subunit
DNI88_RS05150	COG0268	Binds directly to 16S ribosomal RNA
DNI88_RS05160	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DNI88_RS05175	COG0443	Heat shock 70 kDa protein
DNI88_RS05180	COG0484	heat shock protein binding
DNI88_RS05185	COG2264	protein methyltransferase activity
DNI88_RS05190	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DNI88_RS05195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DNI88_RS05215	COG1030	water channel activity
DNI88_RS05220	COG4864	UPF0365 protein
DNI88_RS05230	COG1702	phosphate starvation-inducible protein PhoH
DNI88_RS05240	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DNI88_RS05250	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DNI88_RS05255	COG1381	Involved in DNA repair and RecF pathway recombination
DNI88_RS05260	COG0423	glycine-tRNA ligase activity
DNI88_RS05265	COG0517	IMP dehydrogenase activity
DNI88_RS05270	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DNI88_RS05275	COG0358	DNA primase activity
DNI88_RS05280	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DNI88_RS05285	COG2384	SAM-dependent methyltransferase
DNI88_RS05290	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DNI88_RS05295	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DNI88_RS05300	COG0513	Belongs to the DEAD box helicase family
DNI88_RS05305	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DNI88_RS05310	COG1121	(ABC) transporter
DNI88_RS05315	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DNI88_RS05320	COG0735	belongs to the Fur family
DNI88_RS05325	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DNI88_RS05335	COG0768	penicillin binding
DNI88_RS05340	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DNI88_RS05345	COG0573	inorganic phosphate transmembrane transporter activity
DNI88_RS05350	COG0581	inorganic phosphate transmembrane transporter activity
DNI88_RS05355	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DNI88_RS05360	COG0704	Plays a role in the regulation of phosphate uptake
DNI88_RS05370	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DNI88_RS05375	COG0705	Rhomboid family
DNI88_RS05375	COG0457	Tetratricopeptide repeat
DNI88_RS05380	COG4483	Protein conserved in bacteria
DNI88_RS05385	COG1940	carbohydrate kinase activity
DNI88_RS05390	COG0011	TIGRFAM Protein of
DNI88_RS05395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DNI88_RS05400	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DNI88_RS05430	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DNI88_RS05435	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DNI88_RS05445	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DNI88_RS05450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DNI88_RS05455	COG0095	Lipoate-protein ligase
DNI88_RS05470	COG0006	proline dipeptidase activity
DNI88_RS05475	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DNI88_RS05480	COG0511	ligase activity, forming carbon-carbon bonds
DNI88_RS05485	COG0439	Biotin carboxylase
DNI88_RS05490	COG1302	Protein conserved in bacteria
DNI88_RS05500	COG1570	exodeoxyribonuclease VII activity
DNI88_RS05505	COG1722	exodeoxyribonuclease VII activity
DNI88_RS05510	COG0142	geranyltranstransferase activity
DNI88_RS05515	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DNI88_RS05520	COG1438	arginine binding
DNI88_RS05525	COG0497	DNA recombination
DNI88_RS05530	COG0280	phosphate acetyltransferase
DNI88_RS05535	COG3426	butyrate kinase activity
DNI88_RS05540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DNI88_RS05545	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DNI88_RS05550	COG0022	dehydrogenase e1 component
DNI88_RS05555	COG0508	dehydrogenase complex catalyzes the overall conversion of
DNI88_RS05565	COG4129	membrane
DNI88_RS05575	COG2195	Cleaves the N-terminal amino acid of tripeptides
DNI88_RS05605	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DNI88_RS05610	COG1234	tRNA 3'-trailer cleavage
DNI88_RS05615	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DNI88_RS05625	COG0667	Aldo Keto reductase
DNI88_RS05630	COG0494	nUDIX hydrolase
DNI88_RS05635	COG0735	belongs to the Fur family
DNI88_RS05650	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DNI88_RS05655	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DNI88_RS05660	COG1187	pseudouridine synthase activity
DNI88_RS05665	COG0745	RESPONSE REGULATOR receiver
DNI88_RS05680	COG1141	Ferredoxin
DNI88_RS05690	COG0514	ATP-dependent DNA helicase (RecQ)
DNI88_RS05700	COG0492	ferredoxin-NADP+ reductase activity
DNI88_RS05705	COG0252	asparaginase activity
DNI88_RS05715	COG0539	negative regulation of cytoplasmic translation
DNI88_RS05720	COG1160	GTP binding
DNI88_RS05725	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DNI88_RS05745	COG0142	geranyltranstransferase activity
DNI88_RS05750	COG0105	UTP biosynthetic process
DNI88_RS05760	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DNI88_RS05770	COG0457	Tetratricopeptide repeat
DNI88_RS05775	COG5582	Belongs to the UPF0302 family
DNI88_RS05780	COG4347	Protein of unknown function (DUF1405)
DNI88_RS05790	COG1694	Mazg nucleotide pyrophosphohydrolase
DNI88_RS05795	COG0438	transferase activity, transferring glycosyl groups
DNI88_RS05800	COG0617	tRNA 3'-terminal CCA addition
DNI88_RS05815	COG0017	Asparaginyl-tRNA synthetase
DNI88_RS05820	COG3935	DnaD domain protein
DNI88_RS05825	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DNI88_RS05835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DNI88_RS05835	COG4499	WXG100 protein secretion system (Wss), protein YukC
DNI88_RS05850	COG4474	Belongs to the UPF0398 family
DNI88_RS05855	COG3599	regulation of cell shape
DNI88_RS05865	COG0116	Belongs to the methyltransferase superfamily
DNI88_RS05870	COG2962	Rard protein
DNI88_RS05875	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DNI88_RS05880	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DNI88_RS05890	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DNI88_RS05900	COG1413	lyase activity
DNI88_RS05935	COG2190	(PTS) system
DNI88_RS05945	COG0793	Belongs to the peptidase S41A family
DNI88_RS05955	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DNI88_RS05960	COG0671	phosphoesterase, PA-phosphatase related
DNI88_RS05970	COG5002	protein histidine kinase activity
DNI88_RS05975	COG0567	Dehydrogenase, E1 component
DNI88_RS06000	COG0714	Associated with various cellular activities
DNI88_RS06005	COG4548	von Willebrand factor, type A
DNI88_RS06010	COG1114	Component of the transport system for branched-chain amino acids
DNI88_RS06015	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DNI88_RS06025	COG3853	Toxic anion resistance protein (TelA)
DNI88_RS06045	COG1278	Cold shock
DNI88_RS06065	COG1473	amidohydrolase
DNI88_RS06070	COG2171	N-acyltransferase activity
DNI88_RS06075	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DNI88_RS06080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DNI88_RS06085	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DNI88_RS06090	COG0488	(ABC) transporter
DNI88_RS06095	COG2996	Protein conserved in bacteria
DNI88_RS06145	COG1363	Peptidase, m42
DNI88_RS06150	COG0287	Prephenate dehydrogenase
DNI88_RS06155	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DNI88_RS06165	COG1942	4-Oxalocrotonate Tautomerase
DNI88_RS06190	COG0628	permease
DNI88_RS06205	COG3711	transcriptional antiterminator
DNI88_RS06210	COG1115	amino acid carrier protein
DNI88_RS06215	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DNI88_RS06225	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DNI88_RS06230	COG4841	protein insertion into membrane
DNI88_RS06235	COG0824	Thioesterase
DNI88_RS06245	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DNI88_RS06250	COG1970	mechanosensitive ion channel activity
DNI88_RS06255	COG0419	ATPase involved in DNA repair
DNI88_RS06260	COG0420	3'-5' exonuclease activity
DNI88_RS06265	COG4846	Membrane protein involved in cytochrome C biogenesis
DNI88_RS06270	COG3763	UPF0154 protein
DNI88_RS06280	COG4224	UPF0291 protein
DNI88_RS06290	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DNI88_RS06300	COG0516	GMP reductase activity
DNI88_RS06305	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DNI88_RS06315	COG0833	amino acid
DNI88_RS06330	COG0083	homoserine kinase activity
DNI88_RS06335	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DNI88_RS06340	COG0460	homoserine dehydrogenase
DNI88_RS06345	COG0527	aspartate kinase activity
DNI88_RS06365	COG1525	nuclease
DNI88_RS06395	COG0584	glycerophosphoryl diester phosphodiesterase
DNI88_RS06420	COG0789	Transcriptional regulator
DNI88_RS06425	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DNI88_RS06430	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DNI88_RS06435	COG0386	Belongs to the glutathione peroxidase family
DNI88_RS06440	COG2267	carboxylic ester hydrolase activity
DNI88_RS06445	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DNI88_RS06450	COG1923	regulation of RNA biosynthetic process
DNI88_RS06455	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DNI88_RS06465	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DNI88_RS06470	COG1619	proteins homologs of microcin C7 resistance protein MccF
DNI88_RS06475	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
DNI88_RS06500	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DNI88_RS06510	COG1013	pyruvate-flavodoxin oxidoreductase activity
DNI88_RS06515	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DNI88_RS06515	COG0674	pyruvate-flavodoxin oxidoreductase activity
DNI88_RS06520	COG1692	metallophosphoesterase
DNI88_RS06540	COG1418	mRNA catabolic process
DNI88_RS06545	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DNI88_RS06550	COG1546	Belongs to the CinA family
DNI88_RS06550	COG1058	Belongs to the CinA family
DNI88_RS06570	COG0300	oxidoreductase activity
DNI88_RS06575	COG0612	Peptidase, M16
DNI88_RS06580	COG0612	Peptidase, M16
DNI88_RS06585	COG2188	Transcriptional regulator
DNI88_RS06600	COG1185	polyribonucleotide nucleotidyltransferase activity
DNI88_RS06610	COG0196	riboflavin kinase activity
DNI88_RS06615	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DNI88_RS06620	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DNI88_RS06630	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DNI88_RS06635	COG1358	cellular component organization or biogenesis
DNI88_RS06640	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DNI88_RS06645	COG0195	Participates in both transcription termination and antitermination
DNI88_RS06650	COG0779	Required for maturation of 30S ribosomal subunits
DNI88_RS06660	COG0442	prolyl-tRNA aminoacylation
DNI88_RS06670	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DNI88_RS06675	COG4589	Belongs to the CDS family
DNI88_RS06685	COG0233	cytoplasmic translational termination
DNI88_RS06690	COG0528	UMP kinase activity
DNI88_RS06695	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DNI88_RS06700	COG0052	Belongs to the universal ribosomal protein uS2 family
DNI88_RS06705	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DNI88_RS06710	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DNI88_RS06715	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DNI88_RS06720	COG4974	Belongs to the 'phage' integrase family
DNI88_RS06725	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DNI88_RS06730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DNI88_RS06735	COG0758	DNA mediated transformation
DNI88_RS06745	COG0045	succinate-CoA ligase (ADP-forming) activity
DNI88_RS06755	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DNI88_RS06770	COG4485	Bacterial membrane protein, YfhO
DNI88_RS06810	COG0336	Belongs to the RNA methyltransferase TrmD family
DNI88_RS06815	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DNI88_RS06820	COG0228	four-way junction DNA binding
DNI88_RS06875	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DNI88_RS06880	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DNI88_RS06885	COG0552	protein localization to endoplasmic reticulum
DNI88_RS06890	COG1196	nuclear chromosome segregation
DNI88_RS06895	COG0571	ribonuclease III activity
DNI88_RS06900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DNI88_RS06915	COG0416	fatty acid biosynthetic process
DNI88_RS06920	COG1349	DNA-binding transcription factor activity
DNI88_RS06930	COG1760	l-serine dehydratase
DNI88_RS06935	COG1760	l-serine dehydratase
DNI88_RS06945	COG1302	Protein conserved in bacteria
DNI88_RS06960	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DNI88_RS06965	COG1162	GTPase activity
DNI88_RS06975	COG2124	cytochrome p450
DNI88_RS06990	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DNI88_RS06995	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DNI88_RS06995	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DNI88_RS07000	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DNI88_RS07005	COG0242	peptide deformylase activity
DNI88_RS07010	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DNI88_RS07015	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DNI88_RS07035	COG1758	RNA polymerase activity
DNI88_RS07055	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DNI88_RS07060	COG0284	orotidine-5'-phosphate decarboxylase activity
DNI88_RS07065	COG0167	dihydroorotate dehydrogenase activity
DNI88_RS07075	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DNI88_RS07080	COG0505	Belongs to the CarA family
DNI88_RS07100	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DNI88_RS07105	COG0564	pseudouridine synthase activity
DNI88_RS07110	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DNI88_RS07115	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DNI88_RS07120	COG3599	regulation of cell shape
DNI88_RS07130	COG0673	inositol 2-dehydrogenase activity
DNI88_RS07135	COG4409	exo-alpha-(2->6)-sialidase activity
DNI88_RS07145	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DNI88_RS07150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DNI88_RS07160	COG4975	Glucose uptake
DNI88_RS07165	COG1869	D-ribose catabolic process
DNI88_RS07170	COG0762	integral membrane protein
DNI88_RS07175	COG1799	cell septum assembly
DNI88_RS07180	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DNI88_RS07190	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DNI88_RS07195	COG0849	cell division
DNI88_RS07205	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DNI88_RS07215	COG0768	penicillin binding
DNI88_RS07220	COG4839	cell division protein FtsL
DNI88_RS07225	COG0275	rRNA processing
DNI88_RS07230	COG2001	Belongs to the MraZ family
DNI88_RS07235	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
DNI88_RS07240	COG0454	-acetyltransferase
DNI88_RS07245	COG1011	Hydrolase
DNI88_RS07260	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DNI88_RS07300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DNI88_RS07360	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DNI88_RS07365	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DNI88_RS07370	COG1053	succinate dehydrogenase
DNI88_RS07375	COG2009	succinate dehydrogenase
DNI88_RS07380	COG0322	excinuclease ABC activity
DNI88_RS07385	COG3118	belongs to the thioredoxin family
DNI88_RS07390	COG1193	negative regulation of DNA recombination
DNI88_RS07395	COG1796	DNA polymerase
DNI88_RS07395	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DNI88_RS07410	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DNI88_RS07425	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DNI88_RS07430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DNI88_RS07435	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DNI88_RS07455	COG0742	ribosomal rna small subunit methyltransferase
DNI88_RS07465	COG4471	UPF0298 protein
DNI88_RS07470	COG0584	glycerophosphoryl diester phosphodiesterase
DNI88_RS07475	COG3679	Belongs to the UPF0342 family
DNI88_RS07490	COG0109	protoheme IX farnesyltransferase activity
DNI88_RS07525	COG0772	Belongs to the SEDS family
DNI88_RS07530	COG4838	Belongs to the UPF0358 family
DNI88_RS07535	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DNI88_RS07540	COG4896	Protein conserved in bacteria
DNI88_RS07545	COG1902	pentaerythritol trinitrate reductase activity
DNI88_RS07550	COG1217	gtp-binding protein TYPA
DNI88_RS07560	COG0483	inositol monophosphate 1-phosphatase activity
DNI88_RS07565	COG4493	Belongs to the UPF0637 family
DNI88_RS07580	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DNI88_RS07585	COG1177	transmembrane transport
DNI88_RS07595	COG3842	ATPase activity
DNI88_RS07605	COG4476	Belongs to the UPF0223 family
DNI88_RS07645	COG5503	Protein of unknown function (DUF1447)
DNI88_RS07650	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DNI88_RS07655	COG0569	domain protein
DNI88_RS07660	COG1294	oxidase, subunit
DNI88_RS07665	COG1271	oxidase subunit
DNI88_RS07670	COG1393	Belongs to the ArsC family
DNI88_RS07680	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DNI88_RS07685	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DNI88_RS07695	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DNI88_RS07710	COG4172	Belongs to the ABC transporter superfamily
DNI88_RS07720	COG0151	Belongs to the GarS family
DNI88_RS07725	COG0138	bifunctional purine biosynthesis protein purh
DNI88_RS07735	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DNI88_RS07740	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DNI88_RS07750	COG0047	phosphoribosylformylglycinamidine synthase activity
DNI88_RS07755	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DNI88_RS07760	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DNI88_RS07765	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DNI88_RS07770	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DNI88_RS07775	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DNI88_RS07780	COG1017	nitric oxide dioxygenase activity
DNI88_RS07780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DNI88_RS07790	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DNI88_RS07800	COG1845	cytochrome c oxidase, subunit III
DNI88_RS07805	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DNI88_RS07815	COG3212	peptidase
DNI88_RS07830	COG1134	teichoic acid transport
DNI88_RS07840	COG1682	transport, permease protein
DNI88_RS07850	COG1215	transferase activity, transferring glycosyl groups
DNI88_RS07860	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
DNI88_RS07865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DNI88_RS07870	COG1316	TRANSCRIPTIONal
DNI88_RS07895	COG3594	Acyltransferase
DNI88_RS07900	COG0436	Aminotransferase
DNI88_RS07905	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DNI88_RS07915	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DNI88_RS07920	COG1169	isochorismate synthase
DNI88_RS07925	COG1575	Belongs to the MenA family. Type 1 subfamily
DNI88_RS07930	COG0390	transport system, permease component
DNI88_RS07935	COG4619	ABC transporter
DNI88_RS07955	COG4873	Protein conserved in bacteria
DNI88_RS08035	COG2378	regulation of single-species biofilm formation
DNI88_RS08045	COG0456	acetyltransferase
DNI88_RS08055	COG2226	methyltransferase
DNI88_RS08095	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DNI88_RS08095	COG0551	DNA topoisomerase type I activity
DNI88_RS08140	COG0737	Belongs to the 5'-nucleotidase family
DNI88_RS08150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DNI88_RS08155	COG1696	Membrane protein involved in D-alanine export
DNI88_RS08165	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DNI88_RS08170	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DNI88_RS08175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DNI88_RS08180	COG0861	Integral membrane protein TerC family
DNI88_RS08185	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DNI88_RS08195	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DNI88_RS08200	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DNI88_RS08205	COG2814	Major facilitator Superfamily
DNI88_RS08215	COG3715	PTS system
DNI88_RS08220	COG3716	PTS system mannose fructose sorbose family IID component
DNI88_RS08225	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DNI88_RS08230	COG2382	esterase
DNI88_RS08235	COG1115	amino acid carrier protein
DNI88_RS08240	COG0628	permease
DNI88_RS08250	COG0569	domain protein
DNI88_RS08250	COG0475	glutathione-regulated potassium exporter activity
DNI88_RS08255	COG2239	Acts as a magnesium transporter
DNI88_RS08260	COG0564	pseudouridine synthase activity
DNI88_RS08270	COG2357	RelA SpoT domain protein
DNI88_RS08285	COG2346	COG2346, Truncated hemoglobins
DNI88_RS08290	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DNI88_RS08300	COG1164	Oligoendopeptidase f
DNI88_RS08325	COG1393	Belongs to the ArsC family
DNI88_RS08330	COG0180	Tryptophanyl-tRNA synthetase
DNI88_RS08335	COG4166	transmembrane transport
DNI88_RS08340	COG4608	Belongs to the ABC transporter superfamily
DNI88_RS08345	COG0444	Belongs to the ABC transporter superfamily
DNI88_RS08350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DNI88_RS08355	COG0601	transmembrane transport
DNI88_RS08380	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
DNI88_RS08400	COG0561	phosphatase activity
DNI88_RS08405	COG0446	pyridine nucleotide-disulphide oxidoreductase
DNI88_RS08420	COG0179	Fumarylacetoacetate (FAA) hydrolase
DNI88_RS08430	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DNI88_RS08445	COG0166	Belongs to the GPI family
DNI88_RS08450	COG0137	argininosuccinate synthase activity
DNI88_RS08460	COG0584	glycerophosphoryl diester phosphodiesterase
DNI88_RS08475	COG1012	belongs to the aldehyde dehydrogenase family
DNI88_RS08480	COG1098	S1 RNA binding domain
DNI88_RS08490	COG1278	Cold shock
DNI88_RS08510	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DNI88_RS08520	COG2111	Na H antiporter
DNI88_RS08520	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DNI88_RS08525	COG2111	Na H antiporter
DNI88_RS08530	COG1006	Multisubunit Na H antiporter MnhC subunit
DNI88_RS08535	COG0651	ATP synthesis coupled electron transport
DNI88_RS08540	COG1863	multisubunit Na H antiporter MnhE subunit
DNI88_RS08545	COG2212	antiporter activity
DNI88_RS08550	COG1320	monovalent cation:proton antiporter activity
DNI88_RS08560	COG2056	Na+-H+ antiporter family
DNI88_RS08565	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DNI88_RS08570	COG1252	NADH dehydrogenase
DNI88_RS08575	COG0316	Belongs to the HesB IscA family
DNI88_RS08580	COG4844	belongs to the
DNI88_RS08585	COG1252	NADH dehydrogenase
DNI88_RS08590	COG4837	Protein of unknown function (DUF1462)
DNI88_RS08595	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DNI88_RS08600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DNI88_RS08605	COG0647	UMP catabolic process
DNI88_RS08610	COG2445	Protein of unknown function DUF86
DNI88_RS08620	COG4470	Protein conserved in bacteria
DNI88_RS08625	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DNI88_RS08630	COG0737	Belongs to the 5'-nucleotidase family
DNI88_RS08635	COG0730	response to heat
DNI88_RS08640	COG1801	Protein of unknown function DUF72
DNI88_RS08655	COG1253	flavin adenine dinucleotide binding
DNI88_RS08665	COG0719	Fe-S assembly protein
DNI88_RS08670	COG0822	iron-sulfur transferase activity
DNI88_RS08680	COG0719	Fe-S assembly protein
DNI88_RS08685	COG0396	ATPase activity
DNI88_RS08695	COG1464	Belongs to the NlpA lipoprotein family
DNI88_RS08700	COG1464	Belongs to the NlpA lipoprotein family
DNI88_RS08705	COG2011	ABC-type metal ion transport system permease component
DNI88_RS08715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DNI88_RS08720	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DNI88_RS08730	COG1393	Belongs to the ArsC family
DNI88_RS08735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DNI88_RS08745	COG0710	3-dehydroquinate dehydratase activity
DNI88_RS08755	COG1764	response to oxidative stress
DNI88_RS08770	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DNI88_RS08790	COG0346	lactoylglutathione lyase activity
DNI88_RS08820	COG0557	exoribonuclease II activity
DNI88_RS08825	COG1647	Serine aminopeptidase, S33
DNI88_RS08830	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DNI88_RS08840	COG0148	phosphopyruvate hydratase activity
DNI88_RS08845	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DNI88_RS08875	COG1090	epimerase
DNI88_RS08885	COG0740	serine-type endopeptidase activity
DNI88_RS08895	COG1481	regulation of sporulation
DNI88_RS08900	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DNI88_RS08905	COG1660	Displays ATPase and GTPase activities
DNI88_RS08920	COG0110	maltose O-acetyltransferase activity
DNI88_RS08925	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DNI88_RS08930	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DNI88_RS08965	COG0653	protein targeting
DNI88_RS08980	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DNI88_RS08990	COG1739	Uncharacterized protein family UPF0029
DNI88_RS08995	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DNI88_RS09015	COG2195	Cleaves the N-terminal amino acid of tripeptides
DNI88_RS09020	COG1929	Belongs to the glycerate kinase type-1 family
DNI88_RS09025	COG3118	belongs to the thioredoxin family
DNI88_RS09040	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DNI88_RS09050	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DNI88_RS09055	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DNI88_RS09090	COG3104	oligopeptide transport
DNI88_RS09095	COG3104	oligopeptide transport
DNI88_RS09110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DNI88_RS09115	COG1174	glycine betaine transport
DNI88_RS09120	COG0517	IMP dehydrogenase activity
DNI88_RS09120	COG1125	glycine betaine transport
DNI88_RS09125	COG0514	ATP-dependent DNA helicase (RecQ)
DNI88_RS09130	COG0488	(ABC) transporter
DNI88_RS09150	COG0463	Glycosyl transferase, family 2
DNI88_RS09155	COG1368	sulfuric ester hydrolase activity
DNI88_RS09165	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DNI88_RS09185	COG0512	Glutamine amidotransferase of anthranilate synthase
DNI88_RS09195	COG0720	synthase
DNI88_RS09200	COG0602	queuosine metabolic process
DNI88_RS09215	COG0463	Glycosyl transferase, family 2
DNI88_RS09220	COG1253	flavin adenine dinucleotide binding
DNI88_RS09225	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DNI88_RS09225	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DNI88_RS09225	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DNI88_RS09230	COG1105	Belongs to the carbohydrate kinase PfkB family
DNI88_RS09235	COG1349	DNA-binding transcription factor activity
DNI88_RS09255	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DNI88_RS09260	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DNI88_RS09280	COG0039	L-malate dehydrogenase activity
DNI88_RS09300	COG4989	oxidoreductase activity
DNI88_RS09305	COG0523	cobalamin synthesis protein
DNI88_RS09315	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DNI88_RS09320	COG4988	ABC transporter
DNI88_RS09325	COG1968	undecaprenyl-diphosphatase activity
DNI88_RS09335	COG1671	Belongs to the UPF0178 family
DNI88_RS09340	COG1611	Belongs to the LOG family
DNI88_RS09370	COG2839	Protein conserved in bacteria
DNI88_RS09375	COG2814	Major facilitator Superfamily
DNI88_RS09380	COG0583	DNA-binding transcription factor activity
DNI88_RS09395	COG0217	transcriptional regulatory protein
DNI88_RS09400	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DNI88_RS09405	COG2022	thiamine diphosphate biosynthetic process
DNI88_RS09415	COG0352	thiamine-phosphate diphosphorylase activity
DNI88_RS09425	COG3942	CHAP domain
DNI88_RS09425	COG1388	LysM domain
DNI88_RS09430	COG0306	phosphate transporter
DNI88_RS09435	COG1392	Phosphate transport regulator
DNI88_RS09440	COG0577	efflux transmembrane transporter activity
DNI88_RS09445	COG1136	(ABC) transporter
DNI88_RS09455	COG0745	RESPONSE REGULATOR receiver
DNI88_RS09460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DNI88_RS09465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DNI88_RS09475	COG3949	Membrane
DNI88_RS09480	COG0477	Major facilitator Superfamily
DNI88_RS09490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DNI88_RS09495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DNI88_RS09500	COG1120	ATPase activity
DNI88_RS09505	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DNI88_RS09510	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DNI88_RS09530	COG1132	(ABC) transporter
DNI88_RS09535	COG1686	Belongs to the peptidase S11 family
DNI88_RS09550	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DNI88_RS09555	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DNI88_RS09560	COG1682	transport, permease protein
DNI88_RS09570	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
DNI88_RS09585	COG1475	DNA binding
DNI88_RS09590	COG0019	diaminopimelate decarboxylase activity
DNI88_RS09600	COG4264	IucA IucC family
DNI88_RS09605	COG4264	IucA IucC family
DNI88_RS09610	COG2814	Major facilitator Superfamily
DNI88_RS09615	COG4264	IucA IucC family
DNI88_RS09620	COG2423	ornithine cyclodeaminase activity
DNI88_RS09630	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DNI88_RS09635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DNI88_RS09640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DNI88_RS09650	COG1121	(ABC) transporter
DNI88_RS09655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DNI88_RS09660	COG0803	Belongs to the bacterial solute-binding protein 9 family
DNI88_RS09665	COG1320	monovalent cation:proton antiporter activity
DNI88_RS09670	COG2212	antiporter activity
DNI88_RS09675	COG1863	multisubunit Na H antiporter MnhE subunit
DNI88_RS09685	COG1006	Multisubunit Na H antiporter MnhC subunit
DNI88_RS09690	COG2111	Na H antiporter
DNI88_RS09695	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DNI88_RS09695	COG2111	Na H antiporter
DNI88_RS09745	COG0546	phosphoglycolate phosphatase activity
DNI88_RS09750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DNI88_RS09755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DNI88_RS09760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DNI88_RS09765	COG0805	protein transport
DNI88_RS09770	COG0018	arginyl-trna synthetase
DNI88_RS09785	COG1078	dGTPase activity
DNI88_RS09795	COG4844	belongs to the
DNI88_RS09890	COG0741	lytic transglycosylase activity
DNI88_RS09890	COG0791	NLP P60 protein
DNI88_RS09920	COG2946	Replication initiation factor
DNI88_RS09930	COG1674	ftsk spoiiie
DNI88_RS09960	COG0471	metal ion transport
DNI88_RS09990	COG0095	Lipoate-protein ligase
DNI88_RS10010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DNI88_RS10015	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DNI88_RS10025	COG2814	Major facilitator Superfamily
DNI88_RS10030	COG1566	PFAM secretion protein HlyD family protein
DNI88_RS10040	COG2311	Membrane
DNI88_RS10055	COG2363	Small membrane protein
DNI88_RS10085	COG0183	Belongs to the thiolase family
DNI88_RS10090	COG0318	PFAM AMP-dependent synthetase and ligase
DNI88_RS10095	COG0588	phosphoglycerate mutase activity
DNI88_RS10120	COG1131	(ABC) transporter
DNI88_RS10125	COG1994	Peptidase M50
DNI88_RS10130	COG0535	radical SAM domain protein
DNI88_RS10160	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DNI88_RS10170	COG2814	Major facilitator Superfamily
DNI88_RS10180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DNI88_RS10190	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DNI88_RS10205	COG1263	PTS System
DNI88_RS10205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DNI88_RS10205	COG2190	(PTS) system
DNI88_RS10220	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DNI88_RS10225	COG1469	GTP cyclohydrolase I activity
DNI88_RS10230	COG0577	efflux transmembrane transporter activity
DNI88_RS10230	COG1136	(ABC) transporter
DNI88_RS10245	COG0561	phosphatase activity
DNI88_RS10255	COG1428	Deoxynucleoside kinase
DNI88_RS10260	COG1428	Deoxynucleoside kinase
DNI88_RS10265	COG0546	phosphoglycolate phosphatase activity
DNI88_RS10295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DNI88_RS10305	COG1473	amidohydrolase
DNI88_RS10310	COG3527	Alpha-acetolactate decarboxylase
DNI88_RS10315	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DNI88_RS10320	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DNI88_RS10325	COG0049	tRNA binding
DNI88_RS10330	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DNI88_RS10340	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DNI88_RS10345	COG0085	RNA polymerase activity
DNI88_RS10350	COG2813	Specifically methylates the guanine in position
DNI88_RS10360	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DNI88_RS10365	COG0081	regulation of translation
DNI88_RS10370	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DNI88_RS10375	COG0250	Participates in transcription elongation, termination and antitermination
DNI88_RS10380	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DNI88_RS10385	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DNI88_RS10405	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
DNI88_RS10410	COG0215	cysteine-tRNA ligase activity
DNI88_RS10415	COG1045	serine acetyltransferase
DNI88_RS10420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DNI88_RS10430	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DNI88_RS10435	COG4956	integral membrane protein (PIN domain superfamily)
DNI88_RS10440	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DNI88_RS10475	COG0542	response to heat
DNI88_RS10480	COG3869	Catalyzes the specific phosphorylation of arginine residues in
DNI88_RS10485	COG3880	PFAM UvrB UvrC protein
DNI88_RS10495	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DNI88_RS10505	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DNI88_RS10510	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DNI88_RS10515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DNI88_RS10520	COG1289	transmembrane transporter activity
DNI88_RS10610	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DNI88_RS10615	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DNI88_RS10625	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DNI88_RS10635	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DNI88_RS10640	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DNI88_RS10655	COG1098	S1 RNA binding domain
DNI88_RS10665	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DNI88_RS10670	COG3956	TIGRFAM MazG family protein
DNI88_RS10675	COG2244	polysaccharide biosynthetic process
DNI88_RS10680	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DNI88_RS10685	COG0193	aminoacyl-tRNA hydrolase activity
DNI88_RS10695	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DNI88_RS10700	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DNI88_RS10705	COG2088	sporulation resulting in formation of a cellular spore
DNI88_RS10710	COG0251	oxidation-reduction process
DNI88_RS10715	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DNI88_RS10720	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DNI88_RS10725	COG4466	Protein conserved in bacteria
DNI88_RS10735	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DNI88_RS10740	COG0084	hydrolase, TatD family'
DNI88_RS10750	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DNI88_RS10755	COG2827	Endonuclease containing a URI domain
DNI88_RS10760	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DNI88_RS10765	COG4467	Involved in initiation control of chromosome replication
DNI88_RS10770	COG1774	PSP1 C-terminal conserved region
DNI88_RS10775	COG0470	DNA polymerase III
DNI88_RS10780	COG3870	Protein conserved in bacteria
DNI88_RS10785	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DNI88_RS10790	COG1982	Orn Lys Arg decarboxylase major
DNI88_RS10815	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DNI88_RS10820	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DNI88_RS10825	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DNI88_RS10830	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DNI88_RS10840	COG2188	Transcriptional regulator
DNI88_RS10845	COG0366	Alpha amylase catalytic
DNI88_RS10850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DNI88_RS10850	COG1263	PTS System
DNI88_RS10860	COG0493	'glutamate synthase
DNI88_RS10865	COG0069	glutamate synthase activity
DNI88_RS10865	COG0067	glutamate synthase
DNI88_RS10865	COG0070	glutamate synthase
DNI88_RS10870	COG0583	DNA-binding transcription factor activity
DNI88_RS10885	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DNI88_RS10900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DNI88_RS10910	COG0535	radical SAM domain protein
DNI88_RS10915	COG1131	(ABC) transporter
DNI88_RS10960	COG0626	cystathionine gamma-synthase activity
DNI88_RS10965	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DNI88_RS10970	COG2272	Belongs to the type-B carboxylesterase lipase family
DNI88_RS10975	COG0733	neurotransmitter:sodium symporter activity
DNI88_RS10985	COG0745	RESPONSE REGULATOR receiver
DNI88_RS10990	COG2205	protein histidine kinase activity
DNI88_RS11000	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DNI88_RS11005	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DNI88_RS11020	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DNI88_RS11025	COG0574	Belongs to the PEP-utilizing enzyme family
DNI88_RS11025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DNI88_RS11055	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DNI88_RS11065	COG1486	melibiose metabolic process
DNI88_RS11070	COG1263	PTS System
DNI88_RS11070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DNI88_RS11090	COG2210	Belongs to the sulfur carrier protein TusA family
DNI88_RS11095	COG1937	Protein conserved in bacteria
DNI88_RS11100	COG0730	response to heat
DNI88_RS11105	COG2814	Major facilitator Superfamily
DNI88_RS11115	COG3344	reverse transcriptase
DNI88_RS11130	COG3682	Transcriptional regulator
DNI88_RS11155	COG1124	(ABC) transporter
DNI88_RS11160	COG0444	Belongs to the ABC transporter superfamily
DNI88_RS11165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DNI88_RS11170	COG0601	transmembrane transport
DNI88_RS11175	COG0747	negative chemotaxis
DNI88_RS11200	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DNI88_RS11220	COG1525	nuclease
DNI88_RS11255	COG0582	viral genome integration into host DNA
DNI88_RS11260	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DNI88_RS11355	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DNI88_RS11355	COG0519	Catalyzes the synthesis of GMP from XMP
DNI88_RS11360	COG0517	IMP dehydrogenase activity
DNI88_RS11360	COG0516	GMP reductase activity
DNI88_RS11365	COG2233	PERMEase
DNI88_RS11370	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DNI88_RS11385	COG5183	chlorophyll binding
DNI88_RS11390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DNI88_RS11395	COG1823	symporter activity
DNI88_RS11420	COG0778	Nitroreductase
DNI88_RS11425	COG0450	alkyl hydroperoxide reductase
DNI88_RS11440	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DNI88_RS11450	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DNI88_RS11455	COG2011	ABC-type metal ion transport system permease component
DNI88_RS11460	COG1464	Belongs to the NlpA lipoprotein family
DNI88_RS11465	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DNI88_RS11470	COG0753	catalase activity
DNI88_RS11475	COG3842	ATPase activity
DNI88_RS11480	COG0673	inositol 2-dehydrogenase activity
DNI88_RS11485	COG0395	ABC-type sugar transport system, permease component
DNI88_RS11490	COG1175	transmembrane transport
DNI88_RS11500	COG0662	Cupin 2, conserved barrel domain protein
DNI88_RS11500	COG2207	Transcriptional regulator
DNI88_RS11505	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DNI88_RS11515	COG0360	Binds together with S18 to 16S ribosomal RNA
DNI88_RS11525	COG1668	transmembrane transport
DNI88_RS11530	COG1131	(ABC) transporter
DNI88_RS11545	COG0012	GTP binding
DNI88_RS11550	COG4481	Protein conserved in bacteria
DNI88_RS11555	COG0668	transmembrane transport
DNI88_RS11560	COG1475	DNA binding
DNI88_RS11565	COG0626	cystathionine gamma-synthase activity
DNI88_RS11570	COG0626	cystathionine gamma-synthase activity
DNI88_RS11575	COG0646	methionine synthase
DNI88_RS11575	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DNI88_RS11580	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DNI88_RS11585	COG0829	nickel cation binding
DNI88_RS11595	COG0830	nickel cation binding
DNI88_RS11600	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
DNI88_RS11615	COG2388	GCN5-related N-acetyl-transferase
DNI88_RS11620	COG1846	Transcriptional regulator
DNI88_RS11625	COG0346	lactoylglutathione lyase activity
DNI88_RS11630	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DNI88_RS11635	COG0400	carboxylic ester hydrolase activity
DNI88_RS11650	COG0357	Ribosomal RNA small subunit methyltransferase G
DNI88_RS11655	COG0445	tRNA wobble uridine modification
DNI88_RS11660	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DNI88_RS11665	COG0594	ribonuclease P activity
DNI88_RS11675	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DNI88_RS11680	COG0592	DNA-directed DNA polymerase activity
DNI88_RS11685	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DNI88_RS11685	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DNI88_RS11690	COG2501	S4 domain
DNI88_RS11695	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DNI88_RS11700	COG0187	DNA topoisomerase II activity
DNI88_RS11710	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DNI88_RS11715	COG2986	histidine ammonia-lyase
DNI88_RS11725	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DNI88_RS11735	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DNI88_RS11740	COG4241	membrane
DNI88_RS11745	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
DNI88_RS11750	COG0359	binds to the 23S rRNA
DNI88_RS11755	COG0305	Participates in initiation and elongation during chromosome replication
DNI88_RS11760	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DNI88_RS11765	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DNI88_RS11785	COG0745	RESPONSE REGULATOR receiver
DNI88_RS11790	COG5002	protein histidine kinase activity
DNI88_RS11795	COG4863	YycH protein
DNI88_RS11805	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DNI88_RS11830	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DNI88_RS11830	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DNI88_RS11875	COG0584	glycerophosphoryl diester phosphodiesterase
DNI88_RS11880	COG2030	dehydratase
DNI88_RS11930	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DNI88_RS11970	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
DNI88_RS11975	COG1353	crispr-associated protein
DNI88_RS11980	COG1421	Csm2 Type III-A
DNI88_RS11985	COG1337	RAMP superfamily
DNI88_RS11990	COG1567	CRISPR-associated RAMP protein, Csm4 family
DNI88_RS11995	COG1332	CRISPR-associated RAMP protein, Csm5 family
DNI88_RS12030	COG2311	Membrane
DNI88_RS12050	COG0531	amino acid
DNI88_RS12055	COG2217	Heavy metal translocating P-type atpase
DNI88_RS12085	COG2188	Transcriptional regulator
DNI88_RS12090	COG2723	6-phospho-beta-galactosidase activity
DNI88_RS12105	COG0415	Belongs to the DNA photolyase family
DNI88_RS12120	COG0702	epimerase
DNI88_RS12125	COG2130	NADP-dependent
DNI88_RS12140	COG3177	Filamentation induced by cAMP protein fic
DNI88_RS12145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DNI88_RS12155	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DNI88_RS12160	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DNI88_RS12180	COG2235	arginine
DNI88_RS12195	COG2197	response regulator
DNI88_RS12200	COG4585	Histidine kinase
DNI88_RS12200	COG2203	Gaf domain
DNI88_RS12205	COG0842	Transport permease protein
DNI88_RS12210	COG1131	(ABC) transporter
DNI88_RS12230	COG0431	NADPH-dependent FMN reductase
DNI88_RS12245	COG0583	DNA-binding transcription factor activity
DNI88_RS12250	COG1288	antiporter activity
DNI88_RS12255	COG1473	amidohydrolase
DNI88_RS12270	COG1353	crispr-associated protein
DNI88_RS12275	COG1421	Csm2 Type III-A
DNI88_RS12280	COG1337	RAMP superfamily
DNI88_RS12285	COG1567	CRISPR-associated RAMP protein, Csm4 family
DNI88_RS12290	COG1332	CRISPR-associated RAMP protein, Csm5 family
DNI88_RS12310	COG1609	Transcriptional regulator
DNI88_RS12320	COG0673	inositol 2-dehydrogenase activity
DNI88_RS12330	COG0366	Alpha amylase catalytic
DNI88_RS12340	COG3833	ABC-type maltose transport systems, permease component
DNI88_RS12345	COG1175	transmembrane transport
DNI88_RS12355	COG3842	ATPase activity
DNI88_RS12360	COG0475	glutathione-regulated potassium exporter activity
DNI88_RS12365	COG0490	domain, Protein
DNI88_RS12375	COG0346	lactoylglutathione lyase activity
DNI88_RS12410	COG1131	(ABC) transporter
DNI88_RS12420	COG0366	Alpha amylase catalytic
DNI88_RS12425	COG2188	Transcriptional regulator
DNI88_RS12430	COG2222	sugar isomerase
DNI88_RS12435	COG1105	Belongs to the carbohydrate kinase PfkB family
DNI88_RS12450	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DNI88_RS12450	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DNI88_RS12455	COG3715	PTS system
DNI88_RS12460	COG3716	PTS system mannose fructose sorbose family IID component
DNI88_RS12470	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DNI88_RS12490	COG3314	Sporulation integral membrane protein YlbJ
DNI88_RS12510	COG1063	alcohol dehydrogenase
DNI88_RS12525	COG1620	l-lactate permease
DNI88_RS12530	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DNI88_RS12535	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DNI88_RS12540	COG0156	8-amino-7-oxononanoate synthase activity
DNI88_RS12585	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DNI88_RS12600	COG0076	glutamate decarboxylase activity
DNI88_RS12615	COG2318	DinB family
DNI88_RS12620	COG0753	catalase activity
DNI88_RS12630	COG0783	Belongs to the Dps family
DNI88_RS12640	COG0436	Aminotransferase
DNI88_RS12665	COG1136	(ABC) transporter
DNI88_RS12675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DNI88_RS12695	COG1755	Isoprenylcysteine carboxyl methyltransferase
DNI88_RS12720	COG0579	oxidoreductase
DNI88_RS12795	COG1073	alpha beta
DNI88_RS12815	COG0438	transferase activity, transferring glycosyl groups
DNI88_RS12820	COG0183	Belongs to the thiolase family
DNI88_RS12830	COG1960	acyl-CoA dehydrogenase activity
DNI88_RS12835	COG0318	PFAM AMP-dependent synthetase and ligase
DNI88_RS12845	COG2814	Major facilitator Superfamily
DNI88_RS12855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DNI88_RS12885	COG1609	Transcriptional regulator
DNI88_RS12890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DNI88_RS12935	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DNI88_RS12970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DNI88_RS12980	COG3037	sugar-specific permease SgaT UlaA
DNI88_RS12990	COG1328	CTP reductase activity
DNI88_RS13010	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DNI88_RS13015	COG1942	4-Oxalocrotonate Tautomerase
DNI88_RS13025	COG0803	Belongs to the bacterial solute-binding protein 9 family
DNI88_RS13025	COG3443	Belongs to the bacterial solute-binding protein 9 family
DNI88_RS13035	COG1349	DNA-binding transcription factor activity
DNI88_RS13040	COG1012	belongs to the aldehyde dehydrogenase family
DNI88_RS13050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DNI88_RS13055	COG3962	Belongs to the TPP enzyme family
DNI88_RS13060	COG0673	inositol 2-dehydrogenase activity
DNI88_RS13070	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DNI88_RS13075	COG0673	inositol 2-dehydrogenase activity
DNI88_RS13080	COG0191	fructose-bisphosphate aldolase activity
DNI88_RS13105	COG2972	Histidine kinase