locus-tag	class	description
JGZ18_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JGZ18_RS00010	COG0592	DNA-directed DNA polymerase activity
JGZ18_RS00015	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JGZ18_RS00015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JGZ18_RS00020	COG2501	S4 domain
JGZ18_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JGZ18_RS00030	COG0187	DNA topoisomerase II activity
JGZ18_RS00040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JGZ18_RS00045	COG2986	histidine ammonia-lyase
JGZ18_RS00055	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
JGZ18_RS00065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JGZ18_RS00070	COG4241	membrane
JGZ18_RS00075	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
JGZ18_RS00080	COG0359	binds to the 23S rRNA
JGZ18_RS00085	COG0305	Participates in initiation and elongation during chromosome replication
JGZ18_RS00090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JGZ18_RS00095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JGZ18_RS00115	COG0745	RESPONSE REGULATOR receiver
JGZ18_RS00120	COG5002	protein histidine kinase activity
JGZ18_RS00125	COG4863	YycH protein
JGZ18_RS00135	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
JGZ18_RS00165	COG0584	glycerophosphoryl diester phosphodiesterase
JGZ18_RS00170	COG2030	dehydratase
JGZ18_RS00205	COG2210	Belongs to the sulfur carrier protein TusA family
JGZ18_RS00210	COG1937	Protein conserved in bacteria
JGZ18_RS00215	COG0730	response to heat
JGZ18_RS00295	COG0514	ATP-dependent DNA helicase (RecQ)
JGZ18_RS00300	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
JGZ18_RS00310	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
JGZ18_RS00350	COG0531	amino acid
JGZ18_RS00355	COG2217	Heavy metal translocating P-type atpase
JGZ18_RS00370	COG3655	Transcriptional regulator
JGZ18_RS00385	COG2188	Transcriptional regulator
JGZ18_RS00390	COG2723	6-phospho-beta-galactosidase activity
JGZ18_RS00400	COG0415	Belongs to the DNA photolyase family
JGZ18_RS00415	COG0702	epimerase
JGZ18_RS00420	COG2130	NADP-dependent
JGZ18_RS00435	COG3177	Filamentation induced by cAMP protein fic
JGZ18_RS00440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JGZ18_RS00455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JGZ18_RS00475	COG2235	arginine
JGZ18_RS00490	COG2197	response regulator
JGZ18_RS00495	COG2203	Gaf domain
JGZ18_RS00495	COG4585	Histidine kinase
JGZ18_RS00500	COG0842	Transport permease protein
JGZ18_RS00525	COG0431	NADPH-dependent FMN reductase
JGZ18_RS00550	COG1609	Transcriptional regulator
JGZ18_RS00560	COG0673	inositol 2-dehydrogenase activity
JGZ18_RS00570	COG0366	Alpha amylase catalytic
JGZ18_RS00580	COG3833	ABC-type maltose transport systems, permease component
JGZ18_RS00585	COG1175	transmembrane transport
JGZ18_RS00600	COG0475	glutathione-regulated potassium exporter activity
JGZ18_RS00605	COG0490	domain, Protein
JGZ18_RS00615	COG0346	lactoylglutathione lyase activity
JGZ18_RS00645	COG1131	(ABC) transporter
JGZ18_RS00655	COG0366	Alpha amylase catalytic
JGZ18_RS00660	COG2188	Transcriptional regulator
JGZ18_RS00665	COG2222	sugar isomerase
JGZ18_RS00670	COG1105	Belongs to the carbohydrate kinase PfkB family
JGZ18_RS00685	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
JGZ18_RS00685	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JGZ18_RS00690	COG3715	PTS system
JGZ18_RS00695	COG3716	PTS system mannose fructose sorbose family IID component
JGZ18_RS00705	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JGZ18_RS00725	COG3314	Sporulation integral membrane protein YlbJ
JGZ18_RS00745	COG1063	alcohol dehydrogenase
JGZ18_RS00760	COG1620	l-lactate permease
JGZ18_RS00765	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
JGZ18_RS00770	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JGZ18_RS00775	COG0156	8-amino-7-oxononanoate synthase activity
JGZ18_RS00820	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
JGZ18_RS00835	COG0076	glutamate decarboxylase activity
JGZ18_RS00850	COG2318	DinB family
JGZ18_RS00855	COG0753	catalase activity
JGZ18_RS00865	COG0783	Belongs to the Dps family
JGZ18_RS00875	COG0436	Aminotransferase
JGZ18_RS00900	COG1136	(ABC) transporter
JGZ18_RS00910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JGZ18_RS00930	COG1755	Isoprenylcysteine carboxyl methyltransferase
JGZ18_RS00955	COG0579	oxidoreductase
JGZ18_RS01020	COG1073	alpha beta
JGZ18_RS01040	COG0438	transferase activity, transferring glycosyl groups
JGZ18_RS01045	COG0183	Belongs to the thiolase family
JGZ18_RS01060	COG0318	PFAM AMP-dependent synthetase and ligase
JGZ18_RS01070	COG2814	Major facilitator Superfamily
JGZ18_RS01080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JGZ18_RS01090	COG1116	anion transmembrane transporter activity
JGZ18_RS01110	COG1609	Transcriptional regulator
JGZ18_RS01115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JGZ18_RS01120	COG1869	D-ribose catabolic process
JGZ18_RS01140	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JGZ18_RS01175	COG3711	transcriptional antiterminator
JGZ18_RS01180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JGZ18_RS01190	COG3037	sugar-specific permease SgaT UlaA
JGZ18_RS01200	COG1328	CTP reductase activity
JGZ18_RS01220	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JGZ18_RS01225	COG1942	4-Oxalocrotonate Tautomerase
JGZ18_RS01235	COG0803	Belongs to the bacterial solute-binding protein 9 family
JGZ18_RS01235	COG3443	Belongs to the bacterial solute-binding protein 9 family
JGZ18_RS01260	COG2207	Transcriptional regulator
JGZ18_RS01260	COG4753	response regulator
JGZ18_RS01265	COG2972	Histidine kinase
JGZ18_RS01275	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JGZ18_RS01280	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
JGZ18_RS01285	COG0477	Major facilitator Superfamily
JGZ18_RS01290	COG2211	Major facilitator Superfamily
JGZ18_RS01295	COG3250	beta-galactosidase activity
JGZ18_RS01300	COG1957	nucleoside hydrolase
JGZ18_RS01330	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
JGZ18_RS01335	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
JGZ18_RS01340	COG2807	transmembrane transport
JGZ18_RS01345	COG1396	sequence-specific DNA binding
JGZ18_RS01360	COG1785	Belongs to the alkaline phosphatase family
JGZ18_RS01365	COG0494	nUDIX hydrolase
JGZ18_RS01370	COG0556	nucleotide-excision repair
JGZ18_RS01385	COG1510	regulation of RNA biosynthetic process
JGZ18_RS01390	COG1012	belongs to the aldehyde dehydrogenase family
JGZ18_RS01395	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
JGZ18_RS01400	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JGZ18_RS01410	COG0156	8-amino-7-oxononanoate synthase activity
JGZ18_RS01425	COG0107	imidazoleglycerol-phosphate synthase activity
JGZ18_RS01430	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JGZ18_RS01445	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JGZ18_RS01450	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JGZ18_RS01455	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JGZ18_RS01460	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
JGZ18_RS01500	COG2376	Dihydroxyacetone kinase
JGZ18_RS01505	COG1461	Dihydroxyacetone kinase
JGZ18_RS01510	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
JGZ18_RS01515	COG2824	Alkylphosphonate utilization operon protein PhnA
JGZ18_RS01520	COG1012	belongs to the aldehyde dehydrogenase family
JGZ18_RS01535	COG0596	Alpha beta hydrolase
JGZ18_RS01540	COG0789	Transcriptional regulator
JGZ18_RS01545	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JGZ18_RS01545	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JGZ18_RS01545	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JGZ18_RS01555	COG3942	CHAP domain
JGZ18_RS01555	COG1705	Flagellar rod assembly protein muramidase FlgJ
JGZ18_RS01565	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JGZ18_RS01570	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JGZ18_RS01575	COG0747	negative chemotaxis
JGZ18_RS01615	COG0778	Nitroreductase
JGZ18_RS01620	COG3001	Fructosamine kinase
JGZ18_RS01645	COG1136	(ABC) transporter
JGZ18_RS01650	COG0577	efflux transmembrane transporter activity
JGZ18_RS01660	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
JGZ18_RS01670	COG4413	Urea transporter
JGZ18_RS01680	COG0832	Belongs to the urease beta subunit family
JGZ18_RS01685	COG0804	urea catabolic process
JGZ18_RS01690	COG0717	Belongs to the dCTP deaminase family
JGZ18_RS01695	COG0523	cobalamin synthesis protein
JGZ18_RS01705	COG1141	Ferredoxin
JGZ18_RS01730	COG0583	DNA-binding transcription factor activity
JGZ18_RS01740	COG1346	cytolysis
JGZ18_RS01755	COG1846	Transcriptional regulator
JGZ18_RS01760	COG0778	Nitroreductase
JGZ18_RS01765	COG2357	RelA SpoT domain protein
JGZ18_RS01805	COG1028	Short-chain dehydrogenase reductase Sdr
JGZ18_RS01820	COG3835	regulator
JGZ18_RS01825	COG2855	membrane
JGZ18_RS01830	COG3961	Belongs to the TPP enzyme family
JGZ18_RS01835	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JGZ18_RS01840	COG0512	Glutamine amidotransferase of anthranilate synthase
JGZ18_RS01850	COG0134	indole-3-glycerol-phosphate synthase activity
JGZ18_RS01860	COG0133	tryptophan synthase activity
JGZ18_RS01865	COG0159	tryptophan synthase activity
JGZ18_RS01885	COG0277	FAD linked oxidase domain protein
JGZ18_RS01890	COG0247	lactate metabolic process
JGZ18_RS01895	COG1132	(ABC) transporter
JGZ18_RS01900	COG1132	(ABC) transporter
JGZ18_RS01905	COG0789	Transcriptional regulator
JGZ18_RS01910	COG3871	stress protein (general stress protein 26)
JGZ18_RS01915	COG1115	amino acid carrier protein
JGZ18_RS01920	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
JGZ18_RS01925	COG2814	Major facilitator Superfamily
JGZ18_RS01930	COG2271	Major facilitator Superfamily
JGZ18_RS01935	COG3764	Sortase (surface protein transpeptidase)
JGZ18_RS01940	COG1929	Belongs to the glycerate kinase type-1 family
JGZ18_RS01950	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
JGZ18_RS01970	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JGZ18_RS01980	COG4166	transmembrane transport
JGZ18_RS01985	COG0444	Belongs to the ABC transporter superfamily
JGZ18_RS01990	COG4608	Belongs to the ABC transporter superfamily
JGZ18_RS01995	COG0601	transmembrane transport
JGZ18_RS02000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JGZ18_RS02005	COG4166	transmembrane transport
JGZ18_RS02010	COG0444	Belongs to the ABC transporter superfamily
JGZ18_RS02015	COG4608	Belongs to the ABC transporter superfamily
JGZ18_RS02020	COG0601	transmembrane transport
JGZ18_RS02025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JGZ18_RS02035	COG1760	l-serine dehydratase
JGZ18_RS02040	COG1760	l-serine dehydratase
JGZ18_RS02090	COG0471	metal ion transport
JGZ18_RS02095	COG2116	formate transmembrane transporter activity
JGZ18_RS02100	COG0454	-acetyltransferase
JGZ18_RS02110	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JGZ18_RS02110	COG1648	precorrin-2 dehydrogenase activity
JGZ18_RS02115	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JGZ18_RS02120	COG2146	nitrite reductase [NAD(P)H] activity
JGZ18_RS02125	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JGZ18_RS02125	COG1648	precorrin-2 dehydrogenase activity
JGZ18_RS02130	COG0737	Belongs to the 5'-nucleotidase family
JGZ18_RS02140	COG0018	arginyl-trna synthetase
JGZ18_RS02155	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
JGZ18_RS02160	COG1140	nitrate reductase beta subunit
JGZ18_RS02170	COG2181	nitrate reductase activity
JGZ18_RS02180	COG4585	Histidine kinase
JGZ18_RS02185	COG2197	response regulator
JGZ18_RS02190	COG2223	nitrite transmembrane transporter activity
JGZ18_RS02195	COG3344	reverse transcriptase
JGZ18_RS02200	COG4187	Peptidase family M20/M25/M40
JGZ18_RS02210	COG0039	L-malate dehydrogenase activity
JGZ18_RS02215	COG1363	Peptidase, m42
JGZ18_RS02220	COG0697	spore germination
JGZ18_RS02230	COG2807	transmembrane transport
JGZ18_RS02240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JGZ18_RS02240	COG1263	PTS System
JGZ18_RS02255	COG1283	sodium-dependent phosphate transmembrane transporter activity
JGZ18_RS02275	COG0492	ferredoxin-NADP+ reductase activity
JGZ18_RS02280	COG2814	Major facilitator Superfamily
JGZ18_RS02285	COG0604	alcohol dehydrogenase
JGZ18_RS02300	COG1620	l-lactate permease
JGZ18_RS02305	COG0438	transferase activity, transferring glycosyl groups
JGZ18_RS02310	COG0579	oxidoreductase
JGZ18_RS02325	COG0577	efflux transmembrane transporter activity
JGZ18_RS02355	COG3344	reverse transcriptase
JGZ18_RS02365	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
JGZ18_RS02375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JGZ18_RS02395	COG1304	FMN binding
JGZ18_RS02400	COG0523	cobalamin synthesis protein
JGZ18_RS02405	COG0786	glutamate:sodium symporter activity
JGZ18_RS02410	COG2207	Transcriptional regulator
JGZ18_RS02435	COG1757	Na H antiporter
JGZ18_RS02440	COG2094	Belongs to the DNA glycosylase MPG family
JGZ18_RS02445	COG3152	Membrane
JGZ18_RS02450	COG4152	abc transporter atp-binding protein
JGZ18_RS02455	COG1668	transmembrane transport
JGZ18_RS02460	COG1742	UPF0060 membrane protein
JGZ18_RS02465	COG2017	converts alpha-aldose to the beta-anomer
JGZ18_RS02470	COG2258	MOSC domain
JGZ18_RS02485	COG1266	CAAX protease self-immunity
JGZ18_RS02490	COG0583	DNA-binding transcription factor activity
JGZ18_RS02495	COG3314	Sporulation integral membrane protein YlbJ
JGZ18_RS02500	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
JGZ18_RS02505	COG1228	amidohydrolase
JGZ18_RS02510	COG0659	secondary active sulfate transmembrane transporter activity
JGZ18_RS02515	COG1473	amidohydrolase
JGZ18_RS02535	COG0385	Bile acid
JGZ18_RS02545	COG0346	lactoylglutathione lyase activity
JGZ18_RS02550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JGZ18_RS02575	COG1113	amino acid transport
JGZ18_RS02615	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
JGZ18_RS02620	COG3383	formate dehydrogenase (NAD+) activity
JGZ18_RS02645	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JGZ18_RS02650	COG2076	Multidrug Resistance protein
JGZ18_RS02655	COG2076	Multidrug Resistance protein
JGZ18_RS02660	COG3942	CHAP domain
JGZ18_RS02670	COG1757	Na H antiporter
JGZ18_RS02680	COG3942	CHAP domain
JGZ18_RS02700	COG1960	acyl-CoA dehydrogenase activity
JGZ18_RS02705	COG2832	Protein of unknown function (DUF454)
JGZ18_RS02710	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JGZ18_RS02715	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JGZ18_RS02725	COG2186	Transcriptional regulator
JGZ18_RS02735	COG1268	BioY protein
JGZ18_RS02750	COG1609	Transcriptional regulator
JGZ18_RS02755	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JGZ18_RS02760	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JGZ18_RS02765	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
JGZ18_RS02775	COG4149	molybdate abc transporter
JGZ18_RS02780	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
JGZ18_RS02785	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JGZ18_RS02790	COG0521	Mo-molybdopterin cofactor biosynthetic process
JGZ18_RS02810	COG0314	molybdopterin synthase activity
JGZ18_RS02820	COG0746	molybdenum cofactor guanylyltransferase activity
JGZ18_RS02825	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JGZ18_RS02850	COG2348	transferase activity, transferring amino-acyl groups
JGZ18_RS02855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JGZ18_RS02860	COG0436	Aminotransferase
JGZ18_RS02890	COG2252	PERMEase
JGZ18_RS02910	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JGZ18_RS02915	COG0088	Forms part of the polypeptide exit tunnel
JGZ18_RS02920	COG0089	rRNA binding
JGZ18_RS02925	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JGZ18_RS02930	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JGZ18_RS02935	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JGZ18_RS02940	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JGZ18_RS02945	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JGZ18_RS02950	COG0255	Belongs to the universal ribosomal protein uL29 family
JGZ18_RS02960	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JGZ18_RS02975	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JGZ18_RS02980	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JGZ18_RS02985	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JGZ18_RS02995	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JGZ18_RS03000	COG1841	ribosomal large subunit assembly
JGZ18_RS03010	COG0201	protein transport
JGZ18_RS03025	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JGZ18_RS03035	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JGZ18_RS03040	COG0202	RNA polymerase activity
JGZ18_RS03045	COG0203	ribosomal protein L17
JGZ18_RS03050	COG1122	ATPase activity
JGZ18_RS03055	COG1122	ATPase activity
JGZ18_RS03065	COG0101	tRNA pseudouridine synthase activity
JGZ18_RS03070	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JGZ18_RS03090	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JGZ18_RS03095	COG3344	reverse transcriptase
JGZ18_RS03135	COG1349	DNA-binding transcription factor activity
JGZ18_RS03150	COG3684	Belongs to the aldolase LacD family
JGZ18_RS03160	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JGZ18_RS03160	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JGZ18_RS03170	COG0488	(ABC) transporter
JGZ18_RS03175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JGZ18_RS03185	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JGZ18_RS03200	COG1302	Protein conserved in bacteria
JGZ18_RS03205	COG2814	Major facilitator Superfamily
JGZ18_RS03210	COG4264	IucA IucC family
JGZ18_RS03215	COG2814	Major facilitator Superfamily
JGZ18_RS03220	COG4264	IucA IucC family
JGZ18_RS03225	COG3457	Alanine racemase
JGZ18_RS03230	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
JGZ18_RS03235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JGZ18_RS03240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JGZ18_RS03245	COG3314	Sporulation integral membrane protein YlbJ
JGZ18_RS03255	COG1988	membrane-bound metal-dependent
JGZ18_RS03260	COG4284	Utp--glucose-1-phosphate uridylyltransferase
JGZ18_RS03265	COG1272	protein, Hemolysin III
JGZ18_RS03285	COG2814	Major facilitator Superfamily
JGZ18_RS03290	COG0489	protein tyrosine kinase activity
JGZ18_RS03355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JGZ18_RS03370	COG3711	transcriptional antiterminator
JGZ18_RS03390	COG1119	ATPase activity
JGZ18_RS03395	COG0561	phosphatase activity
JGZ18_RS03405	COG2186	Transcriptional regulator
JGZ18_RS03410	COG1482	cell wall glycoprotein biosynthetic process
JGZ18_RS03425	COG1757	Na H antiporter
JGZ18_RS03435	COG0813	purine-nucleoside phosphorylase activity
JGZ18_RS03465	COG3344	reverse transcriptase
JGZ18_RS03480	COG5146	pantothenate kinase activity
JGZ18_RS03495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JGZ18_RS03500	COG3343	RNA polymerase activity
JGZ18_RS03505	COG0504	CTP synthase activity
JGZ18_RS03525	COG4821	SIS domain
JGZ18_RS03530	COG0191	fructose-bisphosphate aldolase activity
JGZ18_RS03535	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JGZ18_RS03540	COG1733	regulation of RNA biosynthetic process
JGZ18_RS03550	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
JGZ18_RS03555	COG0254	rRNA binding
JGZ18_RS03565	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JGZ18_RS03570	COG2890	protein-(glutamine-N5) methyltransferase activity
JGZ18_RS03575	COG0009	L-threonylcarbamoyladenylate synthase
JGZ18_RS03580	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JGZ18_RS03585	COG4475	Protein of unknown function (DUF436)
JGZ18_RS03590	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JGZ18_RS03595	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JGZ18_RS03600	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
JGZ18_RS03610	COG0356	it plays a direct role in the translocation of protons across the membrane
JGZ18_RS03615	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JGZ18_RS03625	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JGZ18_RS03635	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JGZ18_RS03665	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JGZ18_RS03680	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
JGZ18_RS03690	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
JGZ18_RS03695	COG0352	thiamine-phosphate diphosphorylase activity
JGZ18_RS03700	COG0706	membrane insertase activity
JGZ18_RS03705	COG1418	mRNA catabolic process
JGZ18_RS03710	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JGZ18_RS03715	COG1937	Protein conserved in bacteria
JGZ18_RS03730	COG2217	Heavy metal translocating P-type atpase
JGZ18_RS03750	COG0772	Belongs to the SEDS family
JGZ18_RS03755	COG1181	Belongs to the D-alanine--D-alanine ligase family
JGZ18_RS03760	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JGZ18_RS03765	COG0513	Belongs to the DEAD box helicase family
JGZ18_RS03780	COG3402	PFAM membrane-flanked domain
JGZ18_RS03785	COG0736	holo-[acyl-carrier-protein] synthase activity
JGZ18_RS03790	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JGZ18_RS03800	COG2337	Toxic component of a toxin-antitoxin (TA) module
JGZ18_RS03805	COG2208	phosphoserine phosphatase activity
JGZ18_RS03810	COG1366	Belongs to the anti-sigma-factor antagonist family
JGZ18_RS03820	COG1191	sigma factor activity
JGZ18_RS03825	COG2183	response to ionizing radiation
JGZ18_RS03830	COG3091	SprT-like family
JGZ18_RS03875	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JGZ18_RS03885	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JGZ18_RS03890	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JGZ18_RS03900	COG0028	Belongs to the TPP enzyme family
JGZ18_RS03905	COG0129	dihydroxy-acid dehydratase activity
JGZ18_RS03910	COG0802	atpase or kinase
JGZ18_RS03915	COG1214	PFAM Peptidase M22, glycoprotease
JGZ18_RS03920	COG0456	acetyltransferase
JGZ18_RS03925	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JGZ18_RS03935	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JGZ18_RS03940	COG0488	(ABC) transporter
JGZ18_RS03945	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
JGZ18_RS03950	COG2814	Major facilitator Superfamily
JGZ18_RS03955	COG1846	Transcriptional regulator
JGZ18_RS03965	COG2124	cytochrome p450
JGZ18_RS03970	COG1609	Transcriptional regulator
JGZ18_RS03975	COG1621	beta-fructofuranosidase activity
JGZ18_RS03980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JGZ18_RS04000	COG4512	PFAM Accessory gene regulator B
JGZ18_RS04040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JGZ18_RS04045	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JGZ18_RS04065	COG1131	(ABC) transporter
JGZ18_RS04080	COG1070	Carbohydrate kinase
JGZ18_RS04085	COG2610	gluconate transmembrane transporter activity
JGZ18_RS04120	COG2706	6-phosphogluconolactonase activity
JGZ18_RS04125	COG1012	belongs to the aldehyde dehydrogenase family
JGZ18_RS04135	COG1227	inorganic diphosphatase activity
JGZ18_RS04140	COG1335	isochorismatase
JGZ18_RS04150	COG0077	Prephenate dehydratase
JGZ18_RS04150	COG1605	Chorismate mutase
JGZ18_RS04160	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
JGZ18_RS04170	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
JGZ18_RS04180	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JGZ18_RS04185	COG4496	protein, YerC YecD
JGZ18_RS04190	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
JGZ18_RS04195	COG0210	DNA helicase
JGZ18_RS04200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JGZ18_RS04205	COG4851	CamS sex pheromone cAM373 precursor
JGZ18_RS04210	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JGZ18_RS04215	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JGZ18_RS04225	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JGZ18_RS04230	COG1597	lipid kinase activity
JGZ18_RS04255	COG0488	(ABC) transporter
JGZ18_RS04265	COG1396	sequence-specific DNA binding
JGZ18_RS04285	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JGZ18_RS04295	COG1528	Iron-storage protein
JGZ18_RS04310	COG4129	membrane
JGZ18_RS04315	COG0024	Methionine aminopeptidase
JGZ18_RS04340	COG0288	reversible hydration of carbon dioxide
JGZ18_RS04345	COG1295	ribonuclease BN
JGZ18_RS04360	COG4840	Belongs to the UPF0435 family
JGZ18_RS04365	COG2309	aminopeptidase activity
JGZ18_RS04370	COG1607	acyl-coa hydrolase
JGZ18_RS04375	COG0535	radical SAM domain protein
JGZ18_RS04385	COG0693	protein deglycase activity
JGZ18_RS04390	COG0028	Belongs to the TPP enzyme family
JGZ18_RS04395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JGZ18_RS04400	COG2137	regulation of response to DNA damage stimulus
JGZ18_RS04410	COG1134	teichoic acid transport
JGZ18_RS04410	COG1388	LysM domain
JGZ18_RS04420	COG1988	membrane-bound metal-dependent
JGZ18_RS04425	COG1194	a g-specific adenine glycosylase
JGZ18_RS04430	COG3557	Belongs to the UPF0374 family
JGZ18_RS04440	COG0069	glutamate synthase activity
JGZ18_RS04445	COG4129	membrane
JGZ18_RS04450	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JGZ18_RS04455	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JGZ18_RS04465	COG0735	belongs to the Fur family
JGZ18_RS04690	COG0765	amino acid transport
JGZ18_RS04695	COG1126	abc transporter atp-binding protein
JGZ18_RS04700	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JGZ18_RS04710	COG0363	glucosamine-6-phosphate deaminase activity
JGZ18_RS04725	COG0114	fumarate hydratase activity
JGZ18_RS04735	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
JGZ18_RS04740	COG0564	pseudouridine synthase activity
JGZ18_RS04745	COG4585	Histidine kinase
JGZ18_RS04745	COG2203	Gaf domain
JGZ18_RS04750	COG2197	response regulator
JGZ18_RS04760	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
JGZ18_RS04770	COG4399	Belongs to the UPF0754 family
JGZ18_RS04775	COG3679	Belongs to the UPF0342 family
JGZ18_RS04780	COG0420	3'-5' exonuclease activity
JGZ18_RS04790	COG3481	metal-dependent phosphohydrolase, HD sub domain
JGZ18_RS04795	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JGZ18_RS04810	COG1846	Transcriptional regulator
JGZ18_RS04820	COG0537	adenosine 5'-monophosphoramidase activity
JGZ18_RS04825	COG1131	(ABC) transporter
JGZ18_RS04830	COG4473	ABC transporter
JGZ18_RS04840	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JGZ18_RS04855	COG3545	Serine hydrolase
JGZ18_RS04915	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JGZ18_RS05025	COG0756	dUTP diphosphatase activity
JGZ18_RS05080	COG4695	Portal protein
JGZ18_RS05170	COG1388	LysM domain
JGZ18_RS05170	COG5632	N-Acetylmuramoyl-L-alanine amidase
JGZ18_RS05220	COG3037	sugar-specific permease SgaT UlaA
JGZ18_RS05240	COG3623	hexulose-6-phosphate isomerase
JGZ18_RS05245	COG0235	Class ii aldolase
JGZ18_RS05265	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
JGZ18_RS05270	COG0494	nUDIX hydrolase
JGZ18_RS05275	COG1506	peptidase
JGZ18_RS05280	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
JGZ18_RS05285	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JGZ18_RS05295	COG0656	L-ascorbic acid biosynthetic process
JGZ18_RS05300	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JGZ18_RS05305	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JGZ18_RS05315	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JGZ18_RS05340	COG4193	domain, Protein
JGZ18_RS05340	COG5632	N-Acetylmuramoyl-L-alanine amidase
JGZ18_RS05340	COG3266	domain, Protein
JGZ18_RS05350	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JGZ18_RS05350	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JGZ18_RS05355	COG0307	riboflavin synthase, alpha
JGZ18_RS05360	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JGZ18_RS05360	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JGZ18_RS05365	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
JGZ18_RS05380	COG2267	carboxylic ester hydrolase activity
JGZ18_RS05385	COG0039	L-malate dehydrogenase activity
JGZ18_RS05395	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
JGZ18_RS05400	COG1242	4 iron, 4 sulfur cluster binding
JGZ18_RS05405	COG2814	Major facilitator Superfamily
JGZ18_RS05410	COG0495	leucyl-tRNA aminoacylation
JGZ18_RS05415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JGZ18_RS05420	COG2081	HI0933 family
JGZ18_RS05425	COG2244	polysaccharide biosynthetic process
JGZ18_RS05430	COG1187	pseudouridine synthase activity
JGZ18_RS05440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JGZ18_RS05445	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JGZ18_RS05455	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JGZ18_RS05460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JGZ18_RS05470	COG1363	Peptidase, m42
JGZ18_RS05475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JGZ18_RS05480	COG4848	Belongs to the UPF0354 family
JGZ18_RS05485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JGZ18_RS05490	COG1674	ftsk spoiiie
JGZ18_RS05495	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JGZ18_RS05500	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
JGZ18_RS05510	COG1605	Chorismate mutase
JGZ18_RS05510	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
JGZ18_RS05515	COG1609	Transcriptional regulator
JGZ18_RS05520	COG3344	reverse transcriptase
JGZ18_RS05530	COG0454	-acetyltransferase
JGZ18_RS05535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JGZ18_RS05540	COG2759	Belongs to the formate--tetrahydrofolate ligase family
JGZ18_RS05545	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
JGZ18_RS05555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JGZ18_RS05560	COG0204	Acyl-transferase
JGZ18_RS05570	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JGZ18_RS05575	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JGZ18_RS05580	COG1764	response to oxidative stress
JGZ18_RS05615	COG0456	acetyltransferase
JGZ18_RS05650	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JGZ18_RS05655	COG1956	GAF domain-containing protein
JGZ18_RS05660	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
JGZ18_RS05665	COG3344	reverse transcriptase
JGZ18_RS05670	COG1104	cysteine desulfurase activity
JGZ18_RS05675	COG0301	tRNA thio-modification
JGZ18_RS05685	COG0616	signal peptide processing
JGZ18_RS05690	COG1714	RDD family
JGZ18_RS05695	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
JGZ18_RS05700	COG0827	DNA restriction-modification system
JGZ18_RS05705	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JGZ18_RS05710	COG0589	response to stress
JGZ18_RS05715	COG0686	Belongs to the AlaDH PNT family
JGZ18_RS05725	COG0006	proline dipeptidase activity
JGZ18_RS05730	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
JGZ18_RS05740	COG4109	DRTGG domain
JGZ18_RS05745	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
JGZ18_RS05750	COG0587	DNA-directed DNA polymerase activity
JGZ18_RS05755	COG0281	malic enzyme
JGZ18_RS05760	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JGZ18_RS05765	COG0825	malonyl-CoA metabolic process
JGZ18_RS05770	COG0205	6-phosphofructokinase activity
JGZ18_RS05775	COG0469	pyruvate kinase activity
JGZ18_RS05780	COG0372	Belongs to the citrate synthase family
JGZ18_RS05790	COG0745	RESPONSE REGULATOR receiver
JGZ18_RS05795	COG5002	protein histidine kinase activity
JGZ18_RS05800	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JGZ18_RS05800	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JGZ18_RS05825	COG3611	Membrane attachment protein
JGZ18_RS05830	COG1484	DNA-dependent DNA replication
JGZ18_RS05840	COG0833	amino acid
JGZ18_RS05850	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JGZ18_RS05855	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JGZ18_RS05860	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
JGZ18_RS05885	COG0218	Necessary for normal cell division and for the maintenance of normal septation
JGZ18_RS05890	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JGZ18_RS05900	COG0181	hydroxymethylbilane synthase activity
JGZ18_RS05915	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JGZ18_RS05925	COG2818	Glycosylase
JGZ18_RS05930	COG0525	valine-tRNA ligase activity
JGZ18_RS05935	COG0285	dihydrofolate synthase activity
JGZ18_RS05945	COG2003	Belongs to the UPF0758 family
JGZ18_RS05980	COG2868	ribosomal protein
JGZ18_RS05990	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JGZ18_RS06000	COG0632	four-way junction helicase activity
JGZ18_RS06010	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
JGZ18_RS06020	COG1862	Preprotein translocase
JGZ18_RS06025	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JGZ18_RS06025	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JGZ18_RS06030	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JGZ18_RS06030	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
JGZ18_RS06035	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JGZ18_RS06045	COG1490	D-aminoacyl-tRNA deacylase activity
JGZ18_RS06050	COG0860	N-Acetylmuramoyl-L-alanine amidase
JGZ18_RS06060	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JGZ18_RS06070	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JGZ18_RS06075	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JGZ18_RS06080	COG1959	2 iron, 2 sulfur cluster binding
JGZ18_RS06095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JGZ18_RS06100	COG1104	cysteine desulfurase activity
JGZ18_RS06105	COG0482	sulfurtransferase activity
JGZ18_RS06115	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JGZ18_RS06120	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JGZ18_RS06125	COG4472	Bacterial protein of unknown function (DUF965)
JGZ18_RS06135	COG3906	Belongs to the UPF0473 family
JGZ18_RS06140	COG4122	O-methyltransferase activity
JGZ18_RS06145	COG0826	peptidase U32
JGZ18_RS06150	COG0826	peptidase U32
JGZ18_RS06155	COG0572	uridine kinase
JGZ18_RS06165	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JGZ18_RS06170	COG1984	allophanate hydrolase subunit 2
JGZ18_RS06175	COG0511	ligase activity, forming carbon-carbon bonds
JGZ18_RS06180	COG0439	Biotin carboxylase
JGZ18_RS06185	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
JGZ18_RS06190	COG1914	H( )-stimulated, divalent metal cation uptake system
JGZ18_RS06195	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JGZ18_RS06200	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
JGZ18_RS06205	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
JGZ18_RS06210	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JGZ18_RS06215	COG1534	Rna-binding protein
JGZ18_RS06225	COG1713	HD superfamily hydrolase involved in NAD metabolism
JGZ18_RS06230	COG0799	negative regulation of ribosome biogenesis
JGZ18_RS06235	COG2226	methyltransferase
JGZ18_RS06240	COG1555	photosystem II stabilization
JGZ18_RS06240	COG1596	polysaccharide export
JGZ18_RS06245	COG2131	deaminase
JGZ18_RS06250	COG2333	competence protein COMEC
JGZ18_RS06250	COG0658	competence protein
JGZ18_RS06260	COG0268	Binds directly to 16S ribosomal RNA
JGZ18_RS06270	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JGZ18_RS06290	COG0484	heat shock protein binding
JGZ18_RS06295	COG2264	protein methyltransferase activity
JGZ18_RS06300	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JGZ18_RS06305	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JGZ18_RS06320	COG1030	water channel activity
JGZ18_RS06325	COG4864	UPF0365 protein
JGZ18_RS06335	COG1702	phosphate starvation-inducible protein PhoH
JGZ18_RS06345	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JGZ18_RS06355	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JGZ18_RS06360	COG1381	Involved in DNA repair and RecF pathway recombination
JGZ18_RS06365	COG0423	glycine-tRNA ligase activity
JGZ18_RS06370	COG0517	IMP dehydrogenase activity
JGZ18_RS06375	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JGZ18_RS06380	COG0358	DNA primase activity
JGZ18_RS06385	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JGZ18_RS06390	COG2384	SAM-dependent methyltransferase
JGZ18_RS06395	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JGZ18_RS06400	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JGZ18_RS06405	COG0513	Belongs to the DEAD box helicase family
JGZ18_RS06410	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
JGZ18_RS06415	COG1121	(ABC) transporter
JGZ18_RS06420	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JGZ18_RS06425	COG0735	belongs to the Fur family
JGZ18_RS06430	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JGZ18_RS06440	COG0768	penicillin binding
JGZ18_RS06445	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JGZ18_RS06450	COG0573	inorganic phosphate transmembrane transporter activity
JGZ18_RS06455	COG0581	inorganic phosphate transmembrane transporter activity
JGZ18_RS06460	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JGZ18_RS06465	COG0704	Plays a role in the regulation of phosphate uptake
JGZ18_RS06480	COG0705	Rhomboid family
JGZ18_RS06485	COG4483	Protein conserved in bacteria
JGZ18_RS06490	COG1940	carbohydrate kinase activity
JGZ18_RS06495	COG0011	TIGRFAM Protein of
JGZ18_RS06500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JGZ18_RS06510	COG0582	viral genome integration into host DNA
JGZ18_RS06600	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JGZ18_RS06760	COG4824	toxin secretion phage lysis holin
JGZ18_RS06795	COG3969	phosphoadenosine phosphosulfate
JGZ18_RS06800	COG1475	DNA binding
JGZ18_RS06835	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JGZ18_RS06850	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JGZ18_RS06855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JGZ18_RS06860	COG0095	Lipoate-protein ligase
JGZ18_RS06875	COG0006	proline dipeptidase activity
JGZ18_RS06880	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JGZ18_RS06890	COG0439	Biotin carboxylase
JGZ18_RS06895	COG1302	Protein conserved in bacteria
JGZ18_RS06905	COG1570	exodeoxyribonuclease VII activity
JGZ18_RS06910	COG1722	exodeoxyribonuclease VII activity
JGZ18_RS06920	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JGZ18_RS06925	COG1438	arginine binding
JGZ18_RS06930	COG0497	DNA recombination
JGZ18_RS06935	COG0280	phosphate acetyltransferase
JGZ18_RS06940	COG3426	butyrate kinase activity
JGZ18_RS06945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JGZ18_RS06950	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
JGZ18_RS06955	COG0022	dehydrogenase e1 component
JGZ18_RS06960	COG0508	dehydrogenase complex catalyzes the overall conversion of
JGZ18_RS06970	COG4129	membrane
JGZ18_RS06980	COG2195	Cleaves the N-terminal amino acid of tripeptides
JGZ18_RS07010	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
JGZ18_RS07015	COG1234	tRNA 3'-trailer cleavage
JGZ18_RS07020	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JGZ18_RS07030	COG0667	Aldo Keto reductase
JGZ18_RS07035	COG0494	nUDIX hydrolase
JGZ18_RS07040	COG0735	belongs to the Fur family
JGZ18_RS07055	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
JGZ18_RS07060	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
JGZ18_RS07065	COG1187	pseudouridine synthase activity
JGZ18_RS07070	COG0745	RESPONSE REGULATOR receiver
JGZ18_RS07085	COG1141	Ferredoxin
JGZ18_RS07095	COG0514	ATP-dependent DNA helicase (RecQ)
JGZ18_RS07105	COG0492	ferredoxin-NADP+ reductase activity
JGZ18_RS07110	COG0252	asparaginase activity
JGZ18_RS07120	COG0539	negative regulation of cytoplasmic translation
JGZ18_RS07125	COG3344	reverse transcriptase
JGZ18_RS07130	COG1160	GTP binding
JGZ18_RS07135	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JGZ18_RS07155	COG0142	geranyltranstransferase activity
JGZ18_RS07160	COG0105	UTP biosynthetic process
JGZ18_RS07170	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JGZ18_RS07180	COG0457	Tetratricopeptide repeat
JGZ18_RS07185	COG5582	Belongs to the UPF0302 family
JGZ18_RS07190	COG4347	Protein of unknown function (DUF1405)
JGZ18_RS07200	COG1694	Mazg nucleotide pyrophosphohydrolase
JGZ18_RS07205	COG0438	transferase activity, transferring glycosyl groups
JGZ18_RS07210	COG0617	tRNA 3'-terminal CCA addition
JGZ18_RS07225	COG0017	Asparaginyl-tRNA synthetase
JGZ18_RS07235	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JGZ18_RS07245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JGZ18_RS07245	COG4499	WXG100 protein secretion system (Wss), protein YukC
JGZ18_RS07260	COG4474	Belongs to the UPF0398 family
JGZ18_RS07265	COG3599	regulation of cell shape
JGZ18_RS07275	COG0116	Belongs to the methyltransferase superfamily
JGZ18_RS07280	COG2962	Rard protein
JGZ18_RS07285	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
JGZ18_RS07290	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JGZ18_RS07300	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
JGZ18_RS07310	COG1413	lyase activity
JGZ18_RS07345	COG2190	(PTS) system
JGZ18_RS07355	COG0793	Belongs to the peptidase S41A family
JGZ18_RS07370	COG0671	phosphoesterase, PA-phosphatase related
JGZ18_RS07380	COG5002	protein histidine kinase activity
JGZ18_RS07385	COG0567	Dehydrogenase, E1 component
JGZ18_RS07410	COG0714	Associated with various cellular activities
JGZ18_RS07415	COG4548	von Willebrand factor, type A
JGZ18_RS07420	COG1114	Component of the transport system for branched-chain amino acids
JGZ18_RS07425	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JGZ18_RS07435	COG3853	Toxic anion resistance protein (TelA)
JGZ18_RS07455	COG1278	Cold shock
JGZ18_RS07475	COG1473	amidohydrolase
JGZ18_RS07480	COG2171	N-acyltransferase activity
JGZ18_RS07485	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JGZ18_RS07490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JGZ18_RS07495	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JGZ18_RS07500	COG0488	(ABC) transporter
JGZ18_RS07505	COG2996	Protein conserved in bacteria
JGZ18_RS07535	COG1363	Peptidase, m42
JGZ18_RS07540	COG0287	Prephenate dehydrogenase
JGZ18_RS07545	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JGZ18_RS07555	COG1942	4-Oxalocrotonate Tautomerase
JGZ18_RS07575	COG0628	permease
JGZ18_RS07585	COG3711	transcriptional antiterminator
JGZ18_RS07590	COG1115	amino acid carrier protein
JGZ18_RS07595	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JGZ18_RS07605	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
JGZ18_RS07610	COG4841	protein insertion into membrane
JGZ18_RS07615	COG0824	Thioesterase
JGZ18_RS07625	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JGZ18_RS07630	COG1970	mechanosensitive ion channel activity
JGZ18_RS07640	COG0420	3'-5' exonuclease activity
JGZ18_RS07645	COG4846	Membrane protein involved in cytochrome C biogenesis
JGZ18_RS07650	COG3763	UPF0154 protein
JGZ18_RS07660	COG4224	UPF0291 protein
JGZ18_RS07670	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JGZ18_RS07680	COG0516	GMP reductase activity
JGZ18_RS07685	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JGZ18_RS07695	COG0833	amino acid
JGZ18_RS07710	COG0083	homoserine kinase activity
JGZ18_RS07715	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JGZ18_RS07720	COG0460	homoserine dehydrogenase
JGZ18_RS07725	COG0527	aspartate kinase activity
JGZ18_RS07745	COG1525	nuclease
JGZ18_RS07775	COG0584	glycerophosphoryl diester phosphodiesterase
JGZ18_RS07855	COG0789	Transcriptional regulator
JGZ18_RS07860	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
JGZ18_RS07865	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JGZ18_RS07870	COG0386	Belongs to the glutathione peroxidase family
JGZ18_RS07880	COG2267	carboxylic ester hydrolase activity
JGZ18_RS07885	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JGZ18_RS07890	COG1923	regulation of RNA biosynthetic process
JGZ18_RS07895	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JGZ18_RS07905	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JGZ18_RS07910	COG1619	proteins homologs of microcin C7 resistance protein MccF
JGZ18_RS07915	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
JGZ18_RS07920	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
JGZ18_RS07940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JGZ18_RS07950	COG1013	pyruvate-flavodoxin oxidoreductase activity
JGZ18_RS07955	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JGZ18_RS07955	COG0674	pyruvate-flavodoxin oxidoreductase activity
JGZ18_RS07960	COG1692	metallophosphoesterase
JGZ18_RS07980	COG1418	mRNA catabolic process
JGZ18_RS07985	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JGZ18_RS07990	COG1058	Belongs to the CinA family
JGZ18_RS07990	COG1546	Belongs to the CinA family
JGZ18_RS08010	COG0300	oxidoreductase activity
JGZ18_RS08015	COG0612	Peptidase, M16
JGZ18_RS08020	COG0612	Peptidase, M16
JGZ18_RS08025	COG2188	Transcriptional regulator
JGZ18_RS08040	COG1185	polyribonucleotide nucleotidyltransferase activity
JGZ18_RS08050	COG0196	riboflavin kinase activity
JGZ18_RS08055	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JGZ18_RS08060	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JGZ18_RS08070	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JGZ18_RS08075	COG1358	cellular component organization or biogenesis
JGZ18_RS08080	COG2740	Nucleic-acid-binding protein implicated in transcription termination
JGZ18_RS08085	COG0195	Participates in both transcription termination and antitermination
JGZ18_RS08090	COG0779	Required for maturation of 30S ribosomal subunits
JGZ18_RS08100	COG0442	prolyl-tRNA aminoacylation
JGZ18_RS08110	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
JGZ18_RS08115	COG4589	Belongs to the CDS family
JGZ18_RS08125	COG0233	cytoplasmic translational termination
JGZ18_RS08130	COG0528	UMP kinase activity
JGZ18_RS08135	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JGZ18_RS08140	COG0052	Belongs to the universal ribosomal protein uS2 family
JGZ18_RS08145	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
JGZ18_RS08150	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
JGZ18_RS08155	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
JGZ18_RS08160	COG4974	Belongs to the 'phage' integrase family
JGZ18_RS08165	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
JGZ18_RS08170	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JGZ18_RS08175	COG0758	DNA mediated transformation
JGZ18_RS08185	COG0045	succinate-CoA ligase (ADP-forming) activity
JGZ18_RS08195	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JGZ18_RS08210	COG4485	Bacterial membrane protein, YfhO
JGZ18_RS08245	COG0336	Belongs to the RNA methyltransferase TrmD family
JGZ18_RS08250	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JGZ18_RS08255	COG0228	four-way junction DNA binding
JGZ18_RS08275	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
JGZ18_RS08290	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JGZ18_RS08295	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
JGZ18_RS08300	COG0552	protein localization to endoplasmic reticulum
JGZ18_RS08305	COG1196	nuclear chromosome segregation
JGZ18_RS08310	COG0571	ribonuclease III activity
JGZ18_RS08315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JGZ18_RS08330	COG0416	fatty acid biosynthetic process
JGZ18_RS08335	COG1349	DNA-binding transcription factor activity
JGZ18_RS08345	COG1760	l-serine dehydratase
JGZ18_RS08350	COG1760	l-serine dehydratase
JGZ18_RS08360	COG1302	Protein conserved in bacteria
JGZ18_RS08375	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JGZ18_RS08380	COG1162	GTPase activity
JGZ18_RS08385	COG2124	cytochrome p450
JGZ18_RS08400	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JGZ18_RS08405	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JGZ18_RS08405	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JGZ18_RS08410	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JGZ18_RS08415	COG0242	peptide deformylase activity
JGZ18_RS08420	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JGZ18_RS08450	COG1758	RNA polymerase activity
JGZ18_RS08470	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JGZ18_RS08475	COG0284	orotidine-5'-phosphate decarboxylase activity
JGZ18_RS08480	COG0167	dihydroorotate dehydrogenase activity
JGZ18_RS08490	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JGZ18_RS08495	COG0505	Belongs to the CarA family
JGZ18_RS08515	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
JGZ18_RS08520	COG0564	pseudouridine synthase activity
JGZ18_RS08525	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JGZ18_RS08530	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JGZ18_RS08535	COG3599	regulation of cell shape
JGZ18_RS08550	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JGZ18_RS08555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JGZ18_RS08565	COG4975	Glucose uptake
JGZ18_RS08570	COG1869	D-ribose catabolic process
JGZ18_RS08575	COG0762	integral membrane protein
JGZ18_RS08580	COG1799	cell septum assembly
JGZ18_RS08585	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JGZ18_RS08595	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JGZ18_RS08600	COG0849	cell division
JGZ18_RS08610	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JGZ18_RS08620	COG0768	penicillin binding
JGZ18_RS08625	COG4839	cell division protein FtsL
JGZ18_RS08630	COG0275	rRNA processing
JGZ18_RS08635	COG2001	Belongs to the MraZ family
JGZ18_RS08640	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
JGZ18_RS08645	COG0454	-acetyltransferase
JGZ18_RS08650	COG1011	Hydrolase
JGZ18_RS08665	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JGZ18_RS08725	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JGZ18_RS08730	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JGZ18_RS08735	COG1053	succinate dehydrogenase
JGZ18_RS08740	COG2009	succinate dehydrogenase
JGZ18_RS08745	COG0322	excinuclease ABC activity
JGZ18_RS08750	COG3118	belongs to the thioredoxin family
JGZ18_RS08755	COG1193	negative regulation of DNA recombination
JGZ18_RS08760	COG1796	DNA polymerase
JGZ18_RS08760	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JGZ18_RS08775	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JGZ18_RS08790	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JGZ18_RS08795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JGZ18_RS08800	COG0333	Belongs to the bacterial ribosomal protein bL32 family
JGZ18_RS08820	COG0742	ribosomal rna small subunit methyltransferase
JGZ18_RS08830	COG4471	UPF0298 protein
JGZ18_RS08835	COG0584	glycerophosphoryl diester phosphodiesterase
JGZ18_RS08840	COG3679	Belongs to the UPF0342 family
JGZ18_RS08855	COG0109	protoheme IX farnesyltransferase activity
JGZ18_RS08875	COG3344	reverse transcriptase
JGZ18_RS08880	COG0772	Belongs to the SEDS family
JGZ18_RS08885	COG4838	Belongs to the UPF0358 family
JGZ18_RS08890	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
JGZ18_RS08895	COG4896	Protein conserved in bacteria
JGZ18_RS08900	COG1902	pentaerythritol trinitrate reductase activity
JGZ18_RS08905	COG1217	gtp-binding protein TYPA
JGZ18_RS08915	COG0483	inositol monophosphate 1-phosphatase activity
JGZ18_RS08920	COG4493	Belongs to the UPF0637 family
JGZ18_RS08935	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
JGZ18_RS08940	COG1177	transmembrane transport
JGZ18_RS08950	COG3842	ATPase activity
JGZ18_RS08960	COG4476	Belongs to the UPF0223 family
JGZ18_RS09000	COG5503	Protein of unknown function (DUF1447)
JGZ18_RS09005	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
JGZ18_RS09015	COG0492	ferredoxin-NADP+ reductase activity
JGZ18_RS09045	COG0569	domain protein
JGZ18_RS09050	COG1294	oxidase, subunit
JGZ18_RS09055	COG1271	oxidase subunit
JGZ18_RS09060	COG1393	Belongs to the ArsC family
JGZ18_RS09065	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JGZ18_RS09070	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JGZ18_RS09080	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JGZ18_RS09100	COG4172	Belongs to the ABC transporter superfamily
JGZ18_RS09110	COG0151	Belongs to the GarS family
JGZ18_RS09115	COG0138	bifunctional purine biosynthesis protein purh
JGZ18_RS09125	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JGZ18_RS09130	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
JGZ18_RS09140	COG0047	phosphoribosylformylglycinamidine synthase activity
JGZ18_RS09145	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JGZ18_RS09150	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JGZ18_RS09155	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
JGZ18_RS09160	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JGZ18_RS09165	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JGZ18_RS09170	COG1017	nitric oxide dioxygenase activity
JGZ18_RS09170	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JGZ18_RS09180	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JGZ18_RS09190	COG1845	cytochrome c oxidase, subunit III
JGZ18_RS09195	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
JGZ18_RS09210	COG3973	AAA domain
JGZ18_RS09250	COG3212	peptidase
JGZ18_RS09265	COG1134	teichoic acid transport
JGZ18_RS09275	COG1682	transport, permease protein
JGZ18_RS09285	COG1215	transferase activity, transferring glycosyl groups
JGZ18_RS09295	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
JGZ18_RS09300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JGZ18_RS09305	COG1316	TRANSCRIPTIONal
JGZ18_RS09330	COG3594	Acyltransferase
JGZ18_RS09335	COG0436	Aminotransferase
JGZ18_RS09340	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
JGZ18_RS09350	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
JGZ18_RS09360	COG1575	Belongs to the MenA family. Type 1 subfamily
JGZ18_RS09365	COG0390	transport system, permease component
JGZ18_RS09370	COG4619	ABC transporter
JGZ18_RS09390	COG4873	Protein conserved in bacteria
JGZ18_RS09440	COG2378	regulation of single-species biofilm formation
JGZ18_RS09450	COG0456	acetyltransferase
JGZ18_RS09460	COG2226	methyltransferase
JGZ18_RS09520	COG0551	DNA topoisomerase type I activity
JGZ18_RS09520	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JGZ18_RS09545	COG0737	Belongs to the 5'-nucleotidase family
JGZ18_RS09555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JGZ18_RS09560	COG1696	Membrane protein involved in D-alanine export
JGZ18_RS09570	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
JGZ18_RS09575	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JGZ18_RS09585	COG3344	reverse transcriptase
JGZ18_RS09595	COG0861	Integral membrane protein TerC family
JGZ18_RS09600	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
JGZ18_RS09610	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JGZ18_RS09615	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JGZ18_RS09620	COG2814	Major facilitator Superfamily
JGZ18_RS09630	COG3715	PTS system
JGZ18_RS09635	COG3716	PTS system mannose fructose sorbose family IID component
JGZ18_RS09640	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
JGZ18_RS09645	COG2382	esterase
JGZ18_RS09650	COG1115	amino acid carrier protein
JGZ18_RS09655	COG0628	permease
JGZ18_RS09660	COG4409	exo-alpha-(2->6)-sialidase activity
JGZ18_RS09665	COG2211	Major facilitator Superfamily
JGZ18_RS09670	COG0673	inositol 2-dehydrogenase activity
JGZ18_RS09680	COG0475	glutathione-regulated potassium exporter activity
JGZ18_RS09680	COG0569	domain protein
JGZ18_RS09685	COG2239	Acts as a magnesium transporter
JGZ18_RS09690	COG0564	pseudouridine synthase activity
JGZ18_RS09700	COG2357	RelA SpoT domain protein
JGZ18_RS09715	COG2346	COG2346, Truncated hemoglobins
JGZ18_RS09720	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
JGZ18_RS09730	COG1164	Oligoendopeptidase f
JGZ18_RS09745	COG3591	Belongs to the peptidase S1B family
JGZ18_RS09755	COG1393	Belongs to the ArsC family
JGZ18_RS09760	COG0180	Tryptophanyl-tRNA synthetase
JGZ18_RS09765	COG4166	transmembrane transport
JGZ18_RS09770	COG4608	Belongs to the ABC transporter superfamily
JGZ18_RS09775	COG0444	Belongs to the ABC transporter superfamily
JGZ18_RS09780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JGZ18_RS09785	COG0601	transmembrane transport
JGZ18_RS09810	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
JGZ18_RS09830	COG0561	phosphatase activity
JGZ18_RS09835	COG0446	pyridine nucleotide-disulphide oxidoreductase
JGZ18_RS09850	COG0179	Fumarylacetoacetate (FAA) hydrolase
JGZ18_RS09860	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
JGZ18_RS09875	COG0166	Belongs to the GPI family
JGZ18_RS09880	COG0137	argininosuccinate synthase activity
JGZ18_RS09890	COG0584	glycerophosphoryl diester phosphodiesterase
JGZ18_RS09905	COG1012	belongs to the aldehyde dehydrogenase family
JGZ18_RS09910	COG1098	S1 RNA binding domain
JGZ18_RS09920	COG1278	Cold shock
JGZ18_RS09965	COG4604	ABC transporter, ATP-binding protein
JGZ18_RS09995	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JGZ18_RS10005	COG2111	Na H antiporter
JGZ18_RS10005	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JGZ18_RS10010	COG2111	Na H antiporter
JGZ18_RS10015	COG1006	Multisubunit Na H antiporter MnhC subunit
JGZ18_RS10020	COG0651	ATP synthesis coupled electron transport
JGZ18_RS10025	COG1863	multisubunit Na H antiporter MnhE subunit
JGZ18_RS10030	COG2212	antiporter activity
JGZ18_RS10035	COG1320	monovalent cation:proton antiporter activity
JGZ18_RS10045	COG2056	Na+-H+ antiporter family
JGZ18_RS10050	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JGZ18_RS10055	COG1252	NADH dehydrogenase
JGZ18_RS10060	COG0316	Belongs to the HesB IscA family
JGZ18_RS10065	COG4844	belongs to the
JGZ18_RS10070	COG1252	NADH dehydrogenase
JGZ18_RS10075	COG4837	Protein of unknown function (DUF1462)
JGZ18_RS10080	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
JGZ18_RS10085	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JGZ18_RS10090	COG0647	UMP catabolic process
JGZ18_RS10095	COG2445	Protein of unknown function DUF86
JGZ18_RS10105	COG4470	Protein conserved in bacteria
JGZ18_RS10110	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JGZ18_RS10115	COG0737	Belongs to the 5'-nucleotidase family
JGZ18_RS10120	COG0730	response to heat
JGZ18_RS10125	COG1801	Protein of unknown function DUF72
JGZ18_RS10140	COG1253	flavin adenine dinucleotide binding
JGZ18_RS10160	COG5632	N-Acetylmuramoyl-L-alanine amidase
JGZ18_RS10160	COG1388	LysM domain
JGZ18_RS10270	COG1783	phage Terminase large subunit
JGZ18_RS10275	COG3728	DNA packaging
JGZ18_RS10275	COG5484	DNA packaging
JGZ18_RS10370	COG0305	Participates in initiation and elongation during chromosome replication
JGZ18_RS10495	COG0719	Fe-S assembly protein
JGZ18_RS10500	COG0822	iron-sulfur transferase activity
JGZ18_RS10515	COG0396	ATPase activity
JGZ18_RS10530	COG1464	Belongs to the NlpA lipoprotein family
JGZ18_RS10535	COG1464	Belongs to the NlpA lipoprotein family
JGZ18_RS10540	COG2011	ABC-type metal ion transport system permease component
JGZ18_RS10550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JGZ18_RS10555	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
JGZ18_RS10565	COG1393	Belongs to the ArsC family
JGZ18_RS10570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JGZ18_RS10580	COG0710	3-dehydroquinate dehydratase activity
JGZ18_RS10590	COG1764	response to oxidative stress
JGZ18_RS10605	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JGZ18_RS10625	COG0346	lactoylglutathione lyase activity
JGZ18_RS10660	COG1647	Serine aminopeptidase, S33
JGZ18_RS10665	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JGZ18_RS10685	COG0148	phosphopyruvate hydratase activity
JGZ18_RS10690	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
JGZ18_RS10715	COG1090	epimerase
JGZ18_RS10725	COG0740	serine-type endopeptidase activity
JGZ18_RS10750	COG4824	toxin secretion phage lysis holin
JGZ18_RS10970	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JGZ18_RS10990	COG1481	regulation of sporulation
JGZ18_RS10995	COG0391	Required for morphogenesis under gluconeogenic growth conditions
JGZ18_RS11000	COG1660	Displays ATPase and GTPase activities
JGZ18_RS11015	COG0110	maltose O-acetyltransferase activity
JGZ18_RS11020	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JGZ18_RS11025	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
JGZ18_RS11060	COG0653	protein targeting
JGZ18_RS11075	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
JGZ18_RS11085	COG1739	Uncharacterized protein family UPF0029
JGZ18_RS11090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JGZ18_RS11110	COG2195	Cleaves the N-terminal amino acid of tripeptides
JGZ18_RS11115	COG1929	Belongs to the glycerate kinase type-1 family
JGZ18_RS11120	COG3118	belongs to the thioredoxin family
JGZ18_RS11135	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JGZ18_RS11145	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JGZ18_RS11150	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JGZ18_RS11185	COG3104	oligopeptide transport
JGZ18_RS11190	COG3104	oligopeptide transport
JGZ18_RS11205	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JGZ18_RS11210	COG1174	glycine betaine transport
JGZ18_RS11215	COG0517	IMP dehydrogenase activity
JGZ18_RS11215	COG1125	glycine betaine transport
JGZ18_RS11220	COG0514	ATP-dependent DNA helicase (RecQ)
JGZ18_RS11225	COG0488	(ABC) transporter
JGZ18_RS11235	COG2274	protein secretion by the type I secretion system
JGZ18_RS11250	COG0463	Glycosyl transferase, family 2
JGZ18_RS11255	COG1368	sulfuric ester hydrolase activity
JGZ18_RS11265	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JGZ18_RS11285	COG0512	Glutamine amidotransferase of anthranilate synthase
JGZ18_RS11295	COG0720	synthase
JGZ18_RS11300	COG0602	queuosine metabolic process
JGZ18_RS11315	COG0463	Glycosyl transferase, family 2
JGZ18_RS11320	COG1253	flavin adenine dinucleotide binding
JGZ18_RS11325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JGZ18_RS11325	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JGZ18_RS11325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JGZ18_RS11330	COG1105	Belongs to the carbohydrate kinase PfkB family
JGZ18_RS11335	COG1349	DNA-binding transcription factor activity
JGZ18_RS11350	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JGZ18_RS11355	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JGZ18_RS11375	COG0039	L-malate dehydrogenase activity
JGZ18_RS11395	COG4989	oxidoreductase activity
JGZ18_RS11400	COG0523	cobalamin synthesis protein
JGZ18_RS11410	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
JGZ18_RS11415	COG4988	ABC transporter
JGZ18_RS11420	COG1968	undecaprenyl-diphosphatase activity
JGZ18_RS11430	COG1671	Belongs to the UPF0178 family
JGZ18_RS11435	COG1611	Belongs to the LOG family
JGZ18_RS11470	COG2814	Major facilitator Superfamily
JGZ18_RS11475	COG0583	DNA-binding transcription factor activity
JGZ18_RS11490	COG0217	transcriptional regulatory protein
JGZ18_RS11495	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JGZ18_RS11500	COG2022	thiamine diphosphate biosynthetic process
JGZ18_RS11510	COG0352	thiamine-phosphate diphosphorylase activity
JGZ18_RS11520	COG1388	LysM domain
JGZ18_RS11520	COG3942	CHAP domain
JGZ18_RS11525	COG0306	phosphate transporter
JGZ18_RS11530	COG1392	Phosphate transport regulator
JGZ18_RS11535	COG0577	efflux transmembrane transporter activity
JGZ18_RS11540	COG1136	(ABC) transporter
JGZ18_RS11550	COG0745	RESPONSE REGULATOR receiver
JGZ18_RS11555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JGZ18_RS11560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JGZ18_RS11570	COG3949	Membrane
JGZ18_RS11575	COG0477	Major facilitator Superfamily
JGZ18_RS11585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JGZ18_RS11590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JGZ18_RS11595	COG1120	ATPase activity
JGZ18_RS11600	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JGZ18_RS11605	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JGZ18_RS11625	COG1132	(ABC) transporter
JGZ18_RS11630	COG1686	Belongs to the peptidase S11 family
JGZ18_RS11650	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
JGZ18_RS11655	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JGZ18_RS11660	COG1682	transport, permease protein
JGZ18_RS11670	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
JGZ18_RS11675	COG0110	maltose O-acetyltransferase activity
JGZ18_RS11685	COG1475	DNA binding
JGZ18_RS11690	COG0019	diaminopimelate decarboxylase activity
JGZ18_RS11700	COG4264	IucA IucC family
JGZ18_RS11705	COG4264	IucA IucC family
JGZ18_RS11710	COG2814	Major facilitator Superfamily
JGZ18_RS11715	COG4264	IucA IucC family
JGZ18_RS11720	COG2423	ornithine cyclodeaminase activity
JGZ18_RS11730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JGZ18_RS11735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JGZ18_RS11750	COG1121	(ABC) transporter
JGZ18_RS11755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JGZ18_RS11760	COG0803	Belongs to the bacterial solute-binding protein 9 family
JGZ18_RS11765	COG1320	monovalent cation:proton antiporter activity
JGZ18_RS11770	COG2212	antiporter activity
JGZ18_RS11775	COG1863	multisubunit Na H antiporter MnhE subunit
JGZ18_RS11785	COG1006	Multisubunit Na H antiporter MnhC subunit
JGZ18_RS11790	COG2111	Na H antiporter
JGZ18_RS11795	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JGZ18_RS11795	COG2111	Na H antiporter
JGZ18_RS11845	COG0546	phosphoglycolate phosphatase activity
JGZ18_RS11850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JGZ18_RS11855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JGZ18_RS11860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JGZ18_RS11865	COG0805	protein transport
JGZ18_RS11870	COG0018	arginyl-trna synthetase
JGZ18_RS11885	COG1078	dGTPase activity
JGZ18_RS11895	COG4844	belongs to the
JGZ18_RS11960	COG0471	metal ion transport
JGZ18_RS11990	COG0095	Lipoate-protein ligase
JGZ18_RS12010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JGZ18_RS12015	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
JGZ18_RS12025	COG2814	Major facilitator Superfamily
JGZ18_RS12030	COG1566	PFAM secretion protein HlyD family protein
JGZ18_RS12040	COG2311	Membrane
JGZ18_RS12055	COG2363	Small membrane protein
JGZ18_RS12085	COG0183	Belongs to the thiolase family
JGZ18_RS12090	COG0318	PFAM AMP-dependent synthetase and ligase
JGZ18_RS12095	COG0588	phosphoglycerate mutase activity
JGZ18_RS12100	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JGZ18_RS12110	COG2814	Major facilitator Superfamily
JGZ18_RS12120	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JGZ18_RS12130	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
JGZ18_RS12145	COG2190	(PTS) system
JGZ18_RS12145	COG1263	PTS System
JGZ18_RS12145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JGZ18_RS12160	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JGZ18_RS12165	COG1469	GTP cyclohydrolase I activity
JGZ18_RS12210	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JGZ18_RS12215	COG1136	(ABC) transporter
JGZ18_RS12215	COG0577	efflux transmembrane transporter activity
JGZ18_RS12230	COG0561	phosphatase activity
JGZ18_RS12240	COG1428	Deoxynucleoside kinase
JGZ18_RS12245	COG1428	Deoxynucleoside kinase
JGZ18_RS12250	COG0546	phosphoglycolate phosphatase activity
JGZ18_RS12290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JGZ18_RS12300	COG1473	amidohydrolase
JGZ18_RS12305	COG3527	Alpha-acetolactate decarboxylase
JGZ18_RS12310	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JGZ18_RS12315	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JGZ18_RS12320	COG0049	tRNA binding
JGZ18_RS12325	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JGZ18_RS12335	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JGZ18_RS12340	COG0085	RNA polymerase activity
JGZ18_RS12345	COG2813	Specifically methylates the guanine in position
JGZ18_RS12355	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JGZ18_RS12360	COG0081	regulation of translation
JGZ18_RS12365	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JGZ18_RS12370	COG0250	Participates in transcription elongation, termination and antitermination
JGZ18_RS12375	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JGZ18_RS12380	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JGZ18_RS12400	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
JGZ18_RS12405	COG0215	cysteine-tRNA ligase activity
JGZ18_RS12410	COG1045	serine acetyltransferase
JGZ18_RS12415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JGZ18_RS12425	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JGZ18_RS12430	COG4956	integral membrane protein (PIN domain superfamily)
JGZ18_RS12435	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JGZ18_RS12470	COG0542	response to heat
JGZ18_RS12475	COG3869	Catalyzes the specific phosphorylation of arginine residues in
JGZ18_RS12480	COG3880	PFAM UvrB UvrC protein
JGZ18_RS12490	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JGZ18_RS12500	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
JGZ18_RS12505	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
JGZ18_RS12510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JGZ18_RS12515	COG1289	transmembrane transporter activity
JGZ18_RS12605	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JGZ18_RS12610	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JGZ18_RS12620	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JGZ18_RS12630	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
JGZ18_RS12635	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JGZ18_RS12650	COG1098	S1 RNA binding domain
JGZ18_RS12660	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
JGZ18_RS12665	COG3956	TIGRFAM MazG family protein
JGZ18_RS12670	COG2244	polysaccharide biosynthetic process
JGZ18_RS12675	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JGZ18_RS12680	COG0193	aminoacyl-tRNA hydrolase activity
JGZ18_RS12690	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JGZ18_RS12695	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JGZ18_RS12700	COG2088	sporulation resulting in formation of a cellular spore
JGZ18_RS12705	COG0251	oxidation-reduction process
JGZ18_RS12710	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JGZ18_RS12715	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JGZ18_RS12720	COG4466	Protein conserved in bacteria
JGZ18_RS12730	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
JGZ18_RS12735	COG0084	hydrolase, TatD family'
JGZ18_RS12745	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
JGZ18_RS12750	COG2827	Endonuclease containing a URI domain
JGZ18_RS12755	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
JGZ18_RS12760	COG4467	Involved in initiation control of chromosome replication
JGZ18_RS12765	COG1774	PSP1 C-terminal conserved region
JGZ18_RS12770	COG0470	DNA polymerase III
JGZ18_RS12775	COG3870	Protein conserved in bacteria
JGZ18_RS12780	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JGZ18_RS12785	COG1982	Orn Lys Arg decarboxylase major
JGZ18_RS12810	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JGZ18_RS12815	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JGZ18_RS12820	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JGZ18_RS12825	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JGZ18_RS12835	COG2188	Transcriptional regulator
JGZ18_RS12840	COG0366	Alpha amylase catalytic
JGZ18_RS12845	COG1263	PTS System
JGZ18_RS12845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JGZ18_RS12855	COG0493	'glutamate synthase
JGZ18_RS12860	COG0067	glutamate synthase
JGZ18_RS12860	COG0069	glutamate synthase activity
JGZ18_RS12860	COG0070	glutamate synthase
JGZ18_RS12865	COG0583	DNA-binding transcription factor activity
JGZ18_RS12895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JGZ18_RS12905	COG0535	radical SAM domain protein
JGZ18_RS12915	COG1131	(ABC) transporter
JGZ18_RS12960	COG3344	reverse transcriptase
JGZ18_RS12965	COG0626	cystathionine gamma-synthase activity
JGZ18_RS12970	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JGZ18_RS12975	COG2272	Belongs to the type-B carboxylesterase lipase family
JGZ18_RS12980	COG0733	neurotransmitter:sodium symporter activity
JGZ18_RS12990	COG0745	RESPONSE REGULATOR receiver
JGZ18_RS12995	COG2205	protein histidine kinase activity
JGZ18_RS13005	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
JGZ18_RS13010	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
JGZ18_RS13025	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JGZ18_RS13030	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JGZ18_RS13030	COG0574	Belongs to the PEP-utilizing enzyme family
JGZ18_RS13060	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
JGZ18_RS13070	COG1486	melibiose metabolic process
JGZ18_RS13075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JGZ18_RS13075	COG1263	PTS System
JGZ18_RS13095	COG2210	Belongs to the sulfur carrier protein TusA family
JGZ18_RS13100	COG1937	Protein conserved in bacteria
JGZ18_RS13105	COG0730	response to heat
JGZ18_RS13110	COG2814	Major facilitator Superfamily
JGZ18_RS13130	COG3682	Transcriptional regulator
JGZ18_RS13155	COG1124	(ABC) transporter
JGZ18_RS13160	COG0444	Belongs to the ABC transporter superfamily
JGZ18_RS13165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JGZ18_RS13170	COG0601	transmembrane transport
JGZ18_RS13175	COG0747	negative chemotaxis
JGZ18_RS13200	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
JGZ18_RS13220	COG1525	nuclease
JGZ18_RS13260	COG3617	BRO family, N-terminal domain
JGZ18_RS13285	COG0582	viral genome integration into host DNA
JGZ18_RS13290	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JGZ18_RS13290	COG0519	Catalyzes the synthesis of GMP from XMP
JGZ18_RS13295	COG0516	GMP reductase activity
JGZ18_RS13295	COG0517	IMP dehydrogenase activity
JGZ18_RS13300	COG2233	PERMEase
JGZ18_RS13305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JGZ18_RS13320	COG5183	chlorophyll binding
JGZ18_RS13325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JGZ18_RS13330	COG1823	symporter activity
JGZ18_RS13355	COG0778	Nitroreductase
JGZ18_RS13360	COG0450	alkyl hydroperoxide reductase
JGZ18_RS13375	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JGZ18_RS13385	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JGZ18_RS13390	COG2011	ABC-type metal ion transport system permease component
JGZ18_RS13395	COG1464	Belongs to the NlpA lipoprotein family
JGZ18_RS13400	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JGZ18_RS13405	COG0753	catalase activity
JGZ18_RS13415	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JGZ18_RS13425	COG0360	Binds together with S18 to 16S ribosomal RNA
JGZ18_RS13435	COG1668	transmembrane transport
JGZ18_RS13440	COG1131	(ABC) transporter
JGZ18_RS13445	COG0012	GTP binding
JGZ18_RS13475	COG0012	GTP binding
JGZ18_RS13480	COG4481	Protein conserved in bacteria
JGZ18_RS13485	COG0668	transmembrane transport
JGZ18_RS13490	COG1475	DNA binding
JGZ18_RS13495	COG0626	cystathionine gamma-synthase activity
JGZ18_RS13500	COG0626	cystathionine gamma-synthase activity
JGZ18_RS13505	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
JGZ18_RS13505	COG0646	methionine synthase
JGZ18_RS13515	COG0829	nickel cation binding
JGZ18_RS13525	COG0830	nickel cation binding
JGZ18_RS13530	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
JGZ18_RS13540	COG2388	GCN5-related N-acetyl-transferase
JGZ18_RS13545	COG1846	Transcriptional regulator
JGZ18_RS13550	COG0346	lactoylglutathione lyase activity
JGZ18_RS13555	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JGZ18_RS13560	COG0400	carboxylic ester hydrolase activity
JGZ18_RS13575	COG0357	Ribosomal RNA small subunit methyltransferase G
JGZ18_RS13580	COG0445	tRNA wobble uridine modification
JGZ18_RS13585	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
JGZ18_RS13590	COG0594	ribonuclease P activity