locus-tag	class	description
JGZ50_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JGZ50_RS00010	COG0592	DNA-directed DNA polymerase activity
JGZ50_RS00015	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JGZ50_RS00015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JGZ50_RS00020	COG2501	S4 domain
JGZ50_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JGZ50_RS00030	COG0187	DNA topoisomerase II activity
JGZ50_RS00040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JGZ50_RS00045	COG2986	histidine ammonia-lyase
JGZ50_RS00055	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
JGZ50_RS00065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JGZ50_RS00070	COG4241	membrane
JGZ50_RS00075	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
JGZ50_RS00080	COG0359	binds to the 23S rRNA
JGZ50_RS00085	COG0305	Participates in initiation and elongation during chromosome replication
JGZ50_RS00090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JGZ50_RS00095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JGZ50_RS00115	COG0745	RESPONSE REGULATOR receiver
JGZ50_RS00120	COG5002	protein histidine kinase activity
JGZ50_RS00125	COG4863	YycH protein
JGZ50_RS00135	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
JGZ50_RS00140	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
JGZ50_RS00220	COG0531	amino acid
JGZ50_RS00225	COG2217	Heavy metal translocating P-type atpase
JGZ50_RS00235	COG2188	Transcriptional regulator
JGZ50_RS00240	COG2723	6-phospho-beta-galactosidase activity
JGZ50_RS00250	COG0415	Belongs to the DNA photolyase family
JGZ50_RS00265	COG0702	epimerase
JGZ50_RS00270	COG2130	NADP-dependent
JGZ50_RS00285	COG3177	Filamentation induced by cAMP protein fic
JGZ50_RS00290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JGZ50_RS00300	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
JGZ50_RS00305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JGZ50_RS00325	COG2235	arginine
JGZ50_RS00340	COG2197	response regulator
JGZ50_RS00345	COG2203	Gaf domain
JGZ50_RS00345	COG4585	Histidine kinase
JGZ50_RS00350	COG0842	Transport permease protein
JGZ50_RS00355	COG1131	(ABC) transporter
JGZ50_RS00375	COG0431	NADPH-dependent FMN reductase
JGZ50_RS00380	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JGZ50_RS00380	COG3583	domain protein
JGZ50_RS00380	COG4932	domain protein
JGZ50_RS00400	COG1609	Transcriptional regulator
JGZ50_RS00410	COG0673	inositol 2-dehydrogenase activity
JGZ50_RS00420	COG0366	Alpha amylase catalytic
JGZ50_RS00430	COG3833	ABC-type maltose transport systems, permease component
JGZ50_RS00435	COG1175	transmembrane transport
JGZ50_RS00445	COG3842	ATPase activity
JGZ50_RS00450	COG0475	glutathione-regulated potassium exporter activity
JGZ50_RS00455	COG0490	domain, Protein
JGZ50_RS00465	COG0346	lactoylglutathione lyase activity
JGZ50_RS00500	COG1131	(ABC) transporter
JGZ50_RS00515	COG2188	Transcriptional regulator
JGZ50_RS00520	COG2222	sugar isomerase
JGZ50_RS00525	COG1105	Belongs to the carbohydrate kinase PfkB family
JGZ50_RS00540	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
JGZ50_RS00540	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JGZ50_RS00545	COG3715	PTS system
JGZ50_RS00550	COG3716	PTS system mannose fructose sorbose family IID component
JGZ50_RS00560	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JGZ50_RS00580	COG3314	Sporulation integral membrane protein YlbJ
JGZ50_RS00600	COG1063	alcohol dehydrogenase
JGZ50_RS00615	COG1620	l-lactate permease
JGZ50_RS00620	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
JGZ50_RS00625	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JGZ50_RS00630	COG0156	8-amino-7-oxononanoate synthase activity
JGZ50_RS00675	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
JGZ50_RS00690	COG0076	glutamate decarboxylase activity
JGZ50_RS00705	COG2318	DinB family
JGZ50_RS00710	COG0753	catalase activity
JGZ50_RS00720	COG0783	Belongs to the Dps family
JGZ50_RS00730	COG0436	Aminotransferase
JGZ50_RS00755	COG1136	(ABC) transporter
JGZ50_RS00765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JGZ50_RS00780	COG1755	Isoprenylcysteine carboxyl methyltransferase
JGZ50_RS00805	COG0579	oxidoreductase
JGZ50_RS00845	COG1073	alpha beta
JGZ50_RS00865	COG0438	transferase activity, transferring glycosyl groups
JGZ50_RS00870	COG0183	Belongs to the thiolase family
JGZ50_RS00885	COG0318	PFAM AMP-dependent synthetase and ligase
JGZ50_RS00895	COG2814	Major facilitator Superfamily
JGZ50_RS00905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JGZ50_RS00935	COG1609	Transcriptional regulator
JGZ50_RS00940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JGZ50_RS00975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JGZ50_RS00985	COG3037	sugar-specific permease SgaT UlaA
JGZ50_RS00995	COG1328	CTP reductase activity
JGZ50_RS01015	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JGZ50_RS01020	COG1942	4-Oxalocrotonate Tautomerase
JGZ50_RS01030	COG0803	Belongs to the bacterial solute-binding protein 9 family
JGZ50_RS01030	COG3443	Belongs to the bacterial solute-binding protein 9 family
JGZ50_RS01055	COG4753	response regulator
JGZ50_RS01055	COG2207	Transcriptional regulator
JGZ50_RS01060	COG2972	Histidine kinase
JGZ50_RS01075	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JGZ50_RS01080	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JGZ50_RS01085	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
JGZ50_RS01090	COG0477	Major facilitator Superfamily
JGZ50_RS01095	COG2211	Major facilitator Superfamily
JGZ50_RS01100	COG3250	beta-galactosidase activity
JGZ50_RS01105	COG1957	nucleoside hydrolase
JGZ50_RS01120	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
JGZ50_RS01125	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
JGZ50_RS01130	COG2807	transmembrane transport
JGZ50_RS01135	COG1396	sequence-specific DNA binding
JGZ50_RS01150	COG1785	Belongs to the alkaline phosphatase family
JGZ50_RS01155	COG0494	nUDIX hydrolase
JGZ50_RS01165	COG1914	H( )-stimulated, divalent metal cation uptake system
JGZ50_RS01175	COG1510	regulation of RNA biosynthetic process
JGZ50_RS01180	COG1012	belongs to the aldehyde dehydrogenase family
JGZ50_RS01185	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
JGZ50_RS01190	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JGZ50_RS01200	COG0107	imidazoleglycerol-phosphate synthase activity
JGZ50_RS01205	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JGZ50_RS01220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JGZ50_RS01225	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JGZ50_RS01230	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JGZ50_RS01235	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
JGZ50_RS01280	COG2376	Dihydroxyacetone kinase
JGZ50_RS01285	COG1461	Dihydroxyacetone kinase
JGZ50_RS01290	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
JGZ50_RS01295	COG2824	Alkylphosphonate utilization operon protein PhnA
JGZ50_RS01300	COG1012	belongs to the aldehyde dehydrogenase family
JGZ50_RS01315	COG0596	Alpha beta hydrolase
JGZ50_RS01320	COG0789	Transcriptional regulator
JGZ50_RS01325	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JGZ50_RS01325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JGZ50_RS01325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JGZ50_RS01335	COG3942	CHAP domain
JGZ50_RS01335	COG1705	Flagellar rod assembly protein muramidase FlgJ
JGZ50_RS01345	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JGZ50_RS01350	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JGZ50_RS01355	COG0747	negative chemotaxis
JGZ50_RS01380	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JGZ50_RS01380	COG0463	Glycosyl transferase, family 2
JGZ50_RS01385	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JGZ50_RS01385	COG0463	Glycosyl transferase, family 2
JGZ50_RS01390	COG0438	transferase activity, transferring glycosyl groups
JGZ50_RS01415	COG3181	Tripartite tricarboxylate transporter family receptor
JGZ50_RS01420	COG0778	Nitroreductase
JGZ50_RS01425	COG3001	Fructosamine kinase
JGZ50_RS01450	COG1136	(ABC) transporter
JGZ50_RS01455	COG0577	efflux transmembrane transporter activity
JGZ50_RS01475	COG4413	Urea transporter
JGZ50_RS01485	COG0832	Belongs to the urease beta subunit family
JGZ50_RS01490	COG0804	urea catabolic process
JGZ50_RS01495	COG0717	Belongs to the dCTP deaminase family
JGZ50_RS01500	COG0523	cobalamin synthesis protein
JGZ50_RS01510	COG1141	Ferredoxin
JGZ50_RS01535	COG0583	DNA-binding transcription factor activity
JGZ50_RS01545	COG1346	cytolysis
JGZ50_RS01560	COG1846	Transcriptional regulator
JGZ50_RS01565	COG0778	Nitroreductase
JGZ50_RS01570	COG2357	RelA SpoT domain protein
JGZ50_RS01645	COG1028	Short-chain dehydrogenase reductase Sdr
JGZ50_RS01660	COG3835	regulator
JGZ50_RS01665	COG2855	membrane
JGZ50_RS01670	COG3961	Belongs to the TPP enzyme family
JGZ50_RS01675	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JGZ50_RS01680	COG0512	Glutamine amidotransferase of anthranilate synthase
JGZ50_RS01690	COG0134	indole-3-glycerol-phosphate synthase activity
JGZ50_RS01700	COG0133	tryptophan synthase activity
JGZ50_RS01705	COG0159	tryptophan synthase activity
JGZ50_RS01725	COG0277	FAD linked oxidase domain protein
JGZ50_RS01730	COG0247	lactate metabolic process
JGZ50_RS01735	COG1132	(ABC) transporter
JGZ50_RS01740	COG1132	(ABC) transporter
JGZ50_RS01745	COG0789	Transcriptional regulator
JGZ50_RS01750	COG3871	stress protein (general stress protein 26)
JGZ50_RS01755	COG1115	amino acid carrier protein
JGZ50_RS01760	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
JGZ50_RS01765	COG2814	Major facilitator Superfamily
JGZ50_RS01770	COG2271	Major facilitator Superfamily
JGZ50_RS01775	COG3764	Sortase (surface protein transpeptidase)
JGZ50_RS01780	COG1929	Belongs to the glycerate kinase type-1 family
JGZ50_RS01790	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
JGZ50_RS01810	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JGZ50_RS01830	COG1760	l-serine dehydratase
JGZ50_RS01835	COG1760	l-serine dehydratase
JGZ50_RS01865	COG0471	metal ion transport
JGZ50_RS01870	COG2116	formate transmembrane transporter activity
JGZ50_RS01875	COG0454	-acetyltransferase
JGZ50_RS01885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JGZ50_RS01885	COG1648	precorrin-2 dehydrogenase activity
JGZ50_RS01890	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JGZ50_RS01895	COG2146	nitrite reductase [NAD(P)H] activity
JGZ50_RS01900	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JGZ50_RS01900	COG1648	precorrin-2 dehydrogenase activity
JGZ50_RS01905	COG0737	Belongs to the 5'-nucleotidase family
JGZ50_RS01915	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
JGZ50_RS01920	COG1140	nitrate reductase beta subunit
JGZ50_RS01930	COG2181	nitrate reductase activity
JGZ50_RS01940	COG4585	Histidine kinase
JGZ50_RS01945	COG2197	response regulator
JGZ50_RS01950	COG2223	nitrite transmembrane transporter activity
JGZ50_RS01955	COG4187	Peptidase family M20/M25/M40
JGZ50_RS01965	COG0039	L-malate dehydrogenase activity
JGZ50_RS01970	COG1363	Peptidase, m42
JGZ50_RS01975	COG0697	spore germination
JGZ50_RS01985	COG2807	transmembrane transport
JGZ50_RS01995	COG1263	PTS System
JGZ50_RS01995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JGZ50_RS02010	COG1283	sodium-dependent phosphate transmembrane transporter activity
JGZ50_RS02030	COG0492	ferredoxin-NADP+ reductase activity
JGZ50_RS02035	COG2814	Major facilitator Superfamily
JGZ50_RS02040	COG0604	alcohol dehydrogenase
JGZ50_RS02055	COG1620	l-lactate permease
JGZ50_RS02060	COG0438	transferase activity, transferring glycosyl groups
JGZ50_RS02065	COG0579	oxidoreductase
JGZ50_RS02080	COG0577	efflux transmembrane transporter activity
JGZ50_RS02105	COG4640	response to antibiotic
JGZ50_RS02115	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
JGZ50_RS02125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JGZ50_RS02145	COG1304	FMN binding
JGZ50_RS02150	COG0523	cobalamin synthesis protein
JGZ50_RS02180	COG0786	glutamate:sodium symporter activity
JGZ50_RS02185	COG2207	Transcriptional regulator
JGZ50_RS02190	COG3250	beta-galactosidase activity
JGZ50_RS02210	COG1757	Na H antiporter
JGZ50_RS02215	COG2094	Belongs to the DNA glycosylase MPG family
JGZ50_RS02220	COG3152	Membrane
JGZ50_RS02225	COG4152	abc transporter atp-binding protein
JGZ50_RS02230	COG1668	transmembrane transport
JGZ50_RS02235	COG1742	UPF0060 membrane protein
JGZ50_RS02240	COG2017	converts alpha-aldose to the beta-anomer
JGZ50_RS02245	COG2258	MOSC domain
JGZ50_RS02260	COG1266	CAAX protease self-immunity
JGZ50_RS02265	COG0583	DNA-binding transcription factor activity
JGZ50_RS02270	COG3314	Sporulation integral membrane protein YlbJ
JGZ50_RS02275	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
JGZ50_RS02280	COG1228	amidohydrolase
JGZ50_RS02285	COG0659	secondary active sulfate transmembrane transporter activity
JGZ50_RS02290	COG1473	amidohydrolase
JGZ50_RS02310	COG0385	Bile acid
JGZ50_RS02320	COG0346	lactoylglutathione lyase activity
JGZ50_RS02325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JGZ50_RS02350	COG1113	amino acid transport
JGZ50_RS02390	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
JGZ50_RS02420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JGZ50_RS02425	COG2076	Multidrug Resistance protein
JGZ50_RS02430	COG2076	Multidrug Resistance protein
JGZ50_RS02435	COG3942	CHAP domain
JGZ50_RS02445	COG1757	Na H antiporter
JGZ50_RS02455	COG3942	CHAP domain
JGZ50_RS02475	COG1960	acyl-CoA dehydrogenase activity
JGZ50_RS02480	COG2832	Protein of unknown function (DUF454)
JGZ50_RS02485	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JGZ50_RS02490	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JGZ50_RS02500	COG2186	Transcriptional regulator
JGZ50_RS02510	COG1268	BioY protein
JGZ50_RS02525	COG1609	Transcriptional regulator
JGZ50_RS02530	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JGZ50_RS02535	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JGZ50_RS02540	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
JGZ50_RS02550	COG4149	molybdate abc transporter
JGZ50_RS02555	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
JGZ50_RS02560	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JGZ50_RS02565	COG0521	Mo-molybdopterin cofactor biosynthetic process
JGZ50_RS02585	COG0314	molybdopterin synthase activity
JGZ50_RS02595	COG0746	molybdenum cofactor guanylyltransferase activity
JGZ50_RS02600	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JGZ50_RS02630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JGZ50_RS02635	COG0436	Aminotransferase
JGZ50_RS02660	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JGZ50_RS02660	COG0551	DNA topoisomerase type I activity
JGZ50_RS02665	COG2252	PERMEase
JGZ50_RS02685	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JGZ50_RS02690	COG0088	Forms part of the polypeptide exit tunnel
JGZ50_RS02695	COG0089	rRNA binding
JGZ50_RS02700	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JGZ50_RS02705	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JGZ50_RS02710	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JGZ50_RS02715	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JGZ50_RS02720	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JGZ50_RS02725	COG0255	Belongs to the universal ribosomal protein uL29 family
JGZ50_RS02735	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JGZ50_RS02750	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JGZ50_RS02755	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JGZ50_RS02760	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JGZ50_RS02770	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JGZ50_RS02775	COG1841	ribosomal large subunit assembly
JGZ50_RS02785	COG0201	protein transport
JGZ50_RS02800	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JGZ50_RS02810	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JGZ50_RS02815	COG0202	RNA polymerase activity
JGZ50_RS02825	COG1122	ATPase activity
JGZ50_RS02830	COG1122	ATPase activity
JGZ50_RS02840	COG0101	tRNA pseudouridine synthase activity
JGZ50_RS02845	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JGZ50_RS02860	COG1335	isochorismatase
JGZ50_RS02865	COG1349	DNA-binding transcription factor activity
JGZ50_RS02880	COG3684	Belongs to the aldolase LacD family
JGZ50_RS02890	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JGZ50_RS02890	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JGZ50_RS02900	COG0488	(ABC) transporter
JGZ50_RS02905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JGZ50_RS02915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JGZ50_RS02930	COG1302	Protein conserved in bacteria
JGZ50_RS02935	COG2814	Major facilitator Superfamily
JGZ50_RS02940	COG4264	IucA IucC family
JGZ50_RS02945	COG2814	Major facilitator Superfamily
JGZ50_RS02950	COG4264	IucA IucC family
JGZ50_RS02955	COG3457	Alanine racemase
JGZ50_RS02960	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
JGZ50_RS02965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JGZ50_RS02970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JGZ50_RS02975	COG3314	Sporulation integral membrane protein YlbJ
JGZ50_RS02985	COG1988	membrane-bound metal-dependent
JGZ50_RS02990	COG4284	Utp--glucose-1-phosphate uridylyltransferase
JGZ50_RS02995	COG1272	protein, Hemolysin III
JGZ50_RS03015	COG2814	Major facilitator Superfamily
JGZ50_RS03020	COG0489	protein tyrosine kinase activity
JGZ50_RS03085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JGZ50_RS03100	COG3711	transcriptional antiterminator
JGZ50_RS03120	COG1119	ATPase activity
JGZ50_RS03125	COG0561	phosphatase activity
JGZ50_RS03135	COG2186	Transcriptional regulator
JGZ50_RS03140	COG1482	cell wall glycoprotein biosynthetic process
JGZ50_RS03155	COG1757	Na H antiporter
JGZ50_RS03165	COG0813	purine-nucleoside phosphorylase activity
JGZ50_RS03200	COG5146	pantothenate kinase activity
JGZ50_RS03215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JGZ50_RS03225	COG0504	CTP synthase activity
JGZ50_RS03230	COG2271	Major facilitator Superfamily
JGZ50_RS03235	COG4821	SIS domain
JGZ50_RS03240	COG0191	fructose-bisphosphate aldolase activity
JGZ50_RS03245	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JGZ50_RS03250	COG1733	regulation of RNA biosynthetic process
JGZ50_RS03260	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
JGZ50_RS03265	COG0254	rRNA binding
JGZ50_RS03275	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JGZ50_RS03280	COG2890	protein-(glutamine-N5) methyltransferase activity
JGZ50_RS03285	COG0009	L-threonylcarbamoyladenylate synthase
JGZ50_RS03290	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JGZ50_RS03295	COG4475	Protein of unknown function (DUF436)
JGZ50_RS03305	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JGZ50_RS03310	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
JGZ50_RS03320	COG0356	it plays a direct role in the translocation of protons across the membrane
JGZ50_RS03325	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JGZ50_RS03335	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JGZ50_RS03345	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JGZ50_RS03375	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JGZ50_RS03390	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
JGZ50_RS03400	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
JGZ50_RS03405	COG0352	thiamine-phosphate diphosphorylase activity
JGZ50_RS03410	COG0706	membrane insertase activity
JGZ50_RS03415	COG1418	mRNA catabolic process
JGZ50_RS03420	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JGZ50_RS03425	COG1937	Protein conserved in bacteria
JGZ50_RS03440	COG2217	Heavy metal translocating P-type atpase
JGZ50_RS03455	COG0772	Belongs to the SEDS family
JGZ50_RS03460	COG1181	Belongs to the D-alanine--D-alanine ligase family
JGZ50_RS03465	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JGZ50_RS03470	COG0513	Belongs to the DEAD box helicase family
JGZ50_RS03485	COG3402	PFAM membrane-flanked domain
JGZ50_RS03490	COG0736	holo-[acyl-carrier-protein] synthase activity
JGZ50_RS03495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JGZ50_RS03505	COG2337	Toxic component of a toxin-antitoxin (TA) module
JGZ50_RS03510	COG2208	phosphoserine phosphatase activity
JGZ50_RS03515	COG1366	Belongs to the anti-sigma-factor antagonist family
JGZ50_RS03525	COG1191	sigma factor activity
JGZ50_RS03535	COG3091	SprT-like family
JGZ50_RS03590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JGZ50_RS03605	COG0028	Belongs to the TPP enzyme family
JGZ50_RS03610	COG0129	dihydroxy-acid dehydratase activity
JGZ50_RS03615	COG0802	atpase or kinase
JGZ50_RS03620	COG1214	PFAM Peptidase M22, glycoprotease
JGZ50_RS03625	COG0456	acetyltransferase
JGZ50_RS03630	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JGZ50_RS03640	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JGZ50_RS03645	COG0488	(ABC) transporter
JGZ50_RS03650	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
JGZ50_RS03655	COG2814	Major facilitator Superfamily
JGZ50_RS03660	COG1846	Transcriptional regulator
JGZ50_RS03670	COG2124	cytochrome p450
JGZ50_RS03680	COG1609	Transcriptional regulator
JGZ50_RS03685	COG1621	beta-fructofuranosidase activity
JGZ50_RS03690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JGZ50_RS03710	COG4512	PFAM Accessory gene regulator B
JGZ50_RS03755	COG1404	Belongs to the peptidase S8 family
JGZ50_RS03760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JGZ50_RS03765	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JGZ50_RS03775	COG0436	Aminotransferase
JGZ50_RS03785	COG1131	(ABC) transporter
JGZ50_RS03800	COG1070	Carbohydrate kinase
JGZ50_RS03805	COG2610	gluconate transmembrane transporter activity
JGZ50_RS03840	COG2706	6-phosphogluconolactonase activity
JGZ50_RS03845	COG1012	belongs to the aldehyde dehydrogenase family
JGZ50_RS03855	COG1227	inorganic diphosphatase activity
JGZ50_RS03860	COG1335	isochorismatase
JGZ50_RS03870	COG0077	Prephenate dehydratase
JGZ50_RS03880	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
JGZ50_RS03890	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
JGZ50_RS03900	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JGZ50_RS03905	COG4496	protein, YerC YecD
JGZ50_RS03910	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
JGZ50_RS03915	COG0210	DNA helicase
JGZ50_RS03920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JGZ50_RS03925	COG4851	CamS sex pheromone cAM373 precursor
JGZ50_RS03930	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JGZ50_RS03935	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JGZ50_RS03945	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JGZ50_RS03950	COG1597	lipid kinase activity
JGZ50_RS03975	COG0488	(ABC) transporter
JGZ50_RS03980	COG0488	(ABC) transporter
JGZ50_RS03990	COG1396	sequence-specific DNA binding
JGZ50_RS04005	COG2211	Major facilitator Superfamily
JGZ50_RS04015	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JGZ50_RS04025	COG1528	Iron-storage protein
JGZ50_RS04040	COG4129	membrane
JGZ50_RS04045	COG0024	Methionine aminopeptidase
JGZ50_RS04070	COG0288	reversible hydration of carbon dioxide
JGZ50_RS04075	COG1295	ribonuclease BN
JGZ50_RS04090	COG4840	Belongs to the UPF0435 family
JGZ50_RS04095	COG2309	aminopeptidase activity
JGZ50_RS04100	COG1607	acyl-coa hydrolase
JGZ50_RS04105	COG0535	radical SAM domain protein
JGZ50_RS04115	COG0693	protein deglycase activity
JGZ50_RS04120	COG0028	Belongs to the TPP enzyme family
JGZ50_RS04125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JGZ50_RS04130	COG2137	regulation of response to DNA damage stimulus
JGZ50_RS04140	COG1388	LysM domain
JGZ50_RS04140	COG1134	teichoic acid transport
JGZ50_RS04150	COG1988	membrane-bound metal-dependent
JGZ50_RS04155	COG1194	a g-specific adenine glycosylase
JGZ50_RS04160	COG3557	Belongs to the UPF0374 family
JGZ50_RS04170	COG0069	glutamate synthase activity
JGZ50_RS04175	COG4129	membrane
JGZ50_RS04180	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JGZ50_RS04185	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JGZ50_RS04195	COG0735	belongs to the Fur family
JGZ50_RS04420	COG0765	amino acid transport
JGZ50_RS04425	COG1126	abc transporter atp-binding protein
JGZ50_RS04430	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JGZ50_RS04440	COG0363	glucosamine-6-phosphate deaminase activity
JGZ50_RS04460	COG0114	fumarate hydratase activity
JGZ50_RS04465	COG0248	Ppx GppA phosphatase
JGZ50_RS04470	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
JGZ50_RS04475	COG0564	pseudouridine synthase activity
JGZ50_RS04480	COG4585	Histidine kinase
JGZ50_RS04480	COG2203	Gaf domain
JGZ50_RS04485	COG2197	response regulator
JGZ50_RS04495	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
JGZ50_RS04505	COG4399	Belongs to the UPF0754 family
JGZ50_RS04510	COG3679	Belongs to the UPF0342 family
JGZ50_RS04515	COG0420	3'-5' exonuclease activity
JGZ50_RS04525	COG3481	metal-dependent phosphohydrolase, HD sub domain
JGZ50_RS04530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JGZ50_RS04545	COG1846	Transcriptional regulator
JGZ50_RS04555	COG0537	adenosine 5'-monophosphoramidase activity
JGZ50_RS04560	COG1131	(ABC) transporter
JGZ50_RS04565	COG4473	ABC transporter
JGZ50_RS04575	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JGZ50_RS04585	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
JGZ50_RS04590	COG3545	Serine hydrolase
JGZ50_RS04705	COG3037	sugar-specific permease SgaT UlaA
JGZ50_RS04725	COG3623	hexulose-6-phosphate isomerase
JGZ50_RS04730	COG0235	Class ii aldolase
JGZ50_RS04750	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
JGZ50_RS04755	COG0494	nUDIX hydrolase
JGZ50_RS04760	COG1506	peptidase
JGZ50_RS04765	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
JGZ50_RS04770	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JGZ50_RS04780	COG0656	L-ascorbic acid biosynthetic process
JGZ50_RS04785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JGZ50_RS04790	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JGZ50_RS04800	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JGZ50_RS04825	COG5632	N-Acetylmuramoyl-L-alanine amidase
JGZ50_RS04825	COG3266	domain, Protein
JGZ50_RS04825	COG4193	domain, Protein
JGZ50_RS04835	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JGZ50_RS04835	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JGZ50_RS04840	COG0307	riboflavin synthase, alpha
JGZ50_RS04845	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JGZ50_RS04845	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JGZ50_RS04850	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
JGZ50_RS04865	COG2267	carboxylic ester hydrolase activity
JGZ50_RS04870	COG0039	L-malate dehydrogenase activity
JGZ50_RS04880	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
JGZ50_RS04885	COG1242	4 iron, 4 sulfur cluster binding
JGZ50_RS04890	COG2814	Major facilitator Superfamily
JGZ50_RS04895	COG0495	leucyl-tRNA aminoacylation
JGZ50_RS04900	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JGZ50_RS04905	COG2081	HI0933 family
JGZ50_RS04910	COG2244	polysaccharide biosynthetic process
JGZ50_RS04915	COG1187	pseudouridine synthase activity
JGZ50_RS04925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JGZ50_RS04930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JGZ50_RS04940	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JGZ50_RS04945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JGZ50_RS04955	COG1363	Peptidase, m42
JGZ50_RS04960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JGZ50_RS04965	COG4848	Belongs to the UPF0354 family
JGZ50_RS04970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JGZ50_RS04975	COG1674	ftsk spoiiie
JGZ50_RS04980	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JGZ50_RS04985	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
JGZ50_RS04995	COG1605	Chorismate mutase
JGZ50_RS04995	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
JGZ50_RS05000	COG1609	Transcriptional regulator
JGZ50_RS05010	COG0454	-acetyltransferase
JGZ50_RS05015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JGZ50_RS05020	COG2759	Belongs to the formate--tetrahydrofolate ligase family
JGZ50_RS05025	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
JGZ50_RS05035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JGZ50_RS05040	COG0204	Acyl-transferase
JGZ50_RS05050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JGZ50_RS05055	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JGZ50_RS05060	COG1764	response to oxidative stress
JGZ50_RS05110	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JGZ50_RS05115	COG1956	GAF domain-containing protein
JGZ50_RS05120	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
JGZ50_RS05125	COG1104	cysteine desulfurase activity
JGZ50_RS05140	COG0616	signal peptide processing
JGZ50_RS05145	COG1714	RDD family
JGZ50_RS05150	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
JGZ50_RS05155	COG0827	DNA restriction-modification system
JGZ50_RS05160	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JGZ50_RS05165	COG0589	response to stress
JGZ50_RS05170	COG0686	Belongs to the AlaDH PNT family
JGZ50_RS05180	COG0006	proline dipeptidase activity
JGZ50_RS05185	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
JGZ50_RS05195	COG4109	DRTGG domain
JGZ50_RS05200	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
JGZ50_RS05205	COG0587	DNA-directed DNA polymerase activity
JGZ50_RS05210	COG0281	malic enzyme
JGZ50_RS05215	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JGZ50_RS05220	COG0825	malonyl-CoA metabolic process
JGZ50_RS05225	COG0205	6-phosphofructokinase activity
JGZ50_RS05230	COG0469	pyruvate kinase activity
JGZ50_RS05235	COG0372	Belongs to the citrate synthase family
JGZ50_RS05240	COG0538	isocitrate dehydrogenase activity
JGZ50_RS05245	COG0745	RESPONSE REGULATOR receiver
JGZ50_RS05250	COG5002	protein histidine kinase activity
JGZ50_RS05255	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JGZ50_RS05255	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JGZ50_RS05265	COG0237	dephospho-CoA kinase activity
JGZ50_RS05270	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JGZ50_RS05280	COG3611	Membrane attachment protein
JGZ50_RS05285	COG1484	DNA-dependent DNA replication
JGZ50_RS05295	COG0833	amino acid
JGZ50_RS05305	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JGZ50_RS05310	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JGZ50_RS05315	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
JGZ50_RS05340	COG0218	Necessary for normal cell division and for the maintenance of normal septation
JGZ50_RS05345	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JGZ50_RS05355	COG0181	hydroxymethylbilane synthase activity
JGZ50_RS05370	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JGZ50_RS05380	COG2818	Glycosylase
JGZ50_RS05385	COG0525	valine-tRNA ligase activity
JGZ50_RS05390	COG0285	dihydrofolate synthase activity
JGZ50_RS05400	COG2003	Belongs to the UPF0758 family
JGZ50_RS05435	COG2868	ribosomal protein
JGZ50_RS05445	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JGZ50_RS05455	COG0632	four-way junction helicase activity
JGZ50_RS05465	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
JGZ50_RS05475	COG1862	Preprotein translocase
JGZ50_RS05480	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JGZ50_RS05480	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JGZ50_RS05485	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
JGZ50_RS05485	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JGZ50_RS05490	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JGZ50_RS05500	COG1490	D-aminoacyl-tRNA deacylase activity
JGZ50_RS05505	COG0860	N-Acetylmuramoyl-L-alanine amidase
JGZ50_RS05515	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JGZ50_RS05525	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JGZ50_RS05530	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JGZ50_RS05535	COG1959	2 iron, 2 sulfur cluster binding
JGZ50_RS05550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JGZ50_RS05555	COG1104	cysteine desulfurase activity
JGZ50_RS05560	COG0482	sulfurtransferase activity
JGZ50_RS05570	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JGZ50_RS05575	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JGZ50_RS05580	COG4472	Bacterial protein of unknown function (DUF965)
JGZ50_RS05590	COG3906	Belongs to the UPF0473 family
JGZ50_RS05595	COG4122	O-methyltransferase activity
JGZ50_RS05600	COG0826	peptidase U32
JGZ50_RS05605	COG0826	peptidase U32
JGZ50_RS05610	COG0572	uridine kinase
JGZ50_RS05620	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JGZ50_RS05625	COG1984	allophanate hydrolase subunit 2
JGZ50_RS05630	COG0511	ligase activity, forming carbon-carbon bonds
JGZ50_RS05635	COG0439	Biotin carboxylase
JGZ50_RS05640	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
JGZ50_RS05645	COG1914	H( )-stimulated, divalent metal cation uptake system
JGZ50_RS05650	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JGZ50_RS05655	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
JGZ50_RS05660	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
JGZ50_RS05665	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JGZ50_RS05670	COG1534	Rna-binding protein
JGZ50_RS05680	COG1713	HD superfamily hydrolase involved in NAD metabolism
JGZ50_RS05685	COG0799	negative regulation of ribosome biogenesis
JGZ50_RS05690	COG2226	methyltransferase
JGZ50_RS05695	COG1555	photosystem II stabilization
JGZ50_RS05695	COG1596	polysaccharide export
JGZ50_RS05700	COG2131	deaminase
JGZ50_RS05705	COG0658	competence protein
JGZ50_RS05705	COG2333	competence protein COMEC
JGZ50_RS05715	COG0268	Binds directly to 16S ribosomal RNA
JGZ50_RS05725	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JGZ50_RS05740	COG0443	Heat shock 70 kDa protein
JGZ50_RS05745	COG0484	heat shock protein binding
JGZ50_RS05750	COG2264	protein methyltransferase activity
JGZ50_RS05755	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JGZ50_RS05760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JGZ50_RS05775	COG1030	water channel activity
JGZ50_RS05780	COG4864	UPF0365 protein
JGZ50_RS05790	COG1702	phosphate starvation-inducible protein PhoH
JGZ50_RS05800	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JGZ50_RS05810	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JGZ50_RS05815	COG1381	Involved in DNA repair and RecF pathway recombination
JGZ50_RS05820	COG0423	glycine-tRNA ligase activity
JGZ50_RS05825	COG0517	IMP dehydrogenase activity
JGZ50_RS05830	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JGZ50_RS05835	COG0358	DNA primase activity
JGZ50_RS05840	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JGZ50_RS05845	COG2384	SAM-dependent methyltransferase
JGZ50_RS05850	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JGZ50_RS05855	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JGZ50_RS05860	COG0513	Belongs to the DEAD box helicase family
JGZ50_RS05865	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
JGZ50_RS05870	COG1121	(ABC) transporter
JGZ50_RS05875	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JGZ50_RS05880	COG0735	belongs to the Fur family
JGZ50_RS05885	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JGZ50_RS05895	COG0768	penicillin binding
JGZ50_RS05900	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JGZ50_RS05905	COG0573	inorganic phosphate transmembrane transporter activity
JGZ50_RS05910	COG0581	inorganic phosphate transmembrane transporter activity
JGZ50_RS05915	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JGZ50_RS05920	COG0704	Plays a role in the regulation of phosphate uptake
JGZ50_RS05935	COG0705	Rhomboid family
JGZ50_RS05935	COG0457	Tetratricopeptide repeat
JGZ50_RS05940	COG4483	Protein conserved in bacteria
JGZ50_RS05945	COG1940	carbohydrate kinase activity
JGZ50_RS05950	COG0011	TIGRFAM Protein of
JGZ50_RS05955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JGZ50_RS05960	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JGZ50_RS05990	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JGZ50_RS05995	COG0404	The glycine cleavage system catalyzes the degradation of glycine
JGZ50_RS06005	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JGZ50_RS06010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JGZ50_RS06015	COG0095	Lipoate-protein ligase
JGZ50_RS06030	COG0006	proline dipeptidase activity
JGZ50_RS06035	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JGZ50_RS06045	COG0439	Biotin carboxylase
JGZ50_RS06050	COG1302	Protein conserved in bacteria
JGZ50_RS06060	COG1570	exodeoxyribonuclease VII activity
JGZ50_RS06065	COG1722	exodeoxyribonuclease VII activity
JGZ50_RS06070	COG0142	geranyltranstransferase activity
JGZ50_RS06075	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JGZ50_RS06080	COG1438	arginine binding
JGZ50_RS06085	COG0497	DNA recombination
JGZ50_RS06090	COG0280	phosphate acetyltransferase
JGZ50_RS06095	COG3426	butyrate kinase activity
JGZ50_RS06100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JGZ50_RS06105	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
JGZ50_RS06110	COG0022	dehydrogenase e1 component
JGZ50_RS06115	COG0508	dehydrogenase complex catalyzes the overall conversion of
JGZ50_RS06125	COG4129	membrane
JGZ50_RS06135	COG2195	Cleaves the N-terminal amino acid of tripeptides
JGZ50_RS06165	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
JGZ50_RS06170	COG1234	tRNA 3'-trailer cleavage
JGZ50_RS06175	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JGZ50_RS06185	COG0667	Aldo Keto reductase
JGZ50_RS06190	COG0494	nUDIX hydrolase
JGZ50_RS06195	COG0735	belongs to the Fur family
JGZ50_RS06210	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
JGZ50_RS06215	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
JGZ50_RS06220	COG1187	pseudouridine synthase activity
JGZ50_RS06225	COG0745	RESPONSE REGULATOR receiver
JGZ50_RS06240	COG1141	Ferredoxin
JGZ50_RS06250	COG0514	ATP-dependent DNA helicase (RecQ)
JGZ50_RS06260	COG0492	ferredoxin-NADP+ reductase activity
JGZ50_RS06265	COG0252	asparaginase activity
JGZ50_RS06275	COG0539	negative regulation of cytoplasmic translation
JGZ50_RS06280	COG1160	GTP binding
JGZ50_RS06285	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JGZ50_RS06305	COG0142	geranyltranstransferase activity
JGZ50_RS06310	COG0105	UTP biosynthetic process
JGZ50_RS06320	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JGZ50_RS06330	COG0457	Tetratricopeptide repeat
JGZ50_RS06335	COG5582	Belongs to the UPF0302 family
JGZ50_RS06340	COG4347	Protein of unknown function (DUF1405)
JGZ50_RS06350	COG1694	Mazg nucleotide pyrophosphohydrolase
JGZ50_RS06355	COG0438	transferase activity, transferring glycosyl groups
JGZ50_RS06360	COG0617	tRNA 3'-terminal CCA addition
JGZ50_RS06375	COG0017	Asparaginyl-tRNA synthetase
JGZ50_RS06380	COG3935	DnaD domain protein
JGZ50_RS06385	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JGZ50_RS06395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JGZ50_RS06395	COG4499	WXG100 protein secretion system (Wss), protein YukC
JGZ50_RS06410	COG4474	Belongs to the UPF0398 family
JGZ50_RS06415	COG3599	regulation of cell shape
JGZ50_RS06430	COG2962	Rard protein
JGZ50_RS06435	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
JGZ50_RS06440	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JGZ50_RS06450	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
JGZ50_RS06460	COG1413	lyase activity
JGZ50_RS06495	COG2190	(PTS) system
JGZ50_RS06505	COG0793	Belongs to the peptidase S41A family
JGZ50_RS06515	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JGZ50_RS06520	COG0671	phosphoesterase, PA-phosphatase related
JGZ50_RS06530	COG5002	protein histidine kinase activity
JGZ50_RS06535	COG0567	Dehydrogenase, E1 component
JGZ50_RS06560	COG0714	Associated with various cellular activities
JGZ50_RS06565	COG4548	von Willebrand factor, type A
JGZ50_RS06570	COG1114	Component of the transport system for branched-chain amino acids
JGZ50_RS06575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JGZ50_RS06580	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JGZ50_RS06585	COG3853	Toxic anion resistance protein (TelA)
JGZ50_RS06605	COG1278	Cold shock
JGZ50_RS06625	COG1473	amidohydrolase
JGZ50_RS06630	COG2171	N-acyltransferase activity
JGZ50_RS06635	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JGZ50_RS06640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JGZ50_RS06645	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JGZ50_RS06650	COG0488	(ABC) transporter
JGZ50_RS06655	COG2996	Protein conserved in bacteria
JGZ50_RS06685	COG1363	Peptidase, m42
JGZ50_RS06690	COG0287	Prephenate dehydrogenase
JGZ50_RS06695	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JGZ50_RS06705	COG1942	4-Oxalocrotonate Tautomerase
JGZ50_RS06725	COG0628	permease
JGZ50_RS06735	COG3711	transcriptional antiterminator
JGZ50_RS06740	COG1115	amino acid carrier protein
JGZ50_RS06745	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JGZ50_RS06755	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
JGZ50_RS06760	COG4841	protein insertion into membrane
JGZ50_RS06765	COG0824	Thioesterase
JGZ50_RS06775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JGZ50_RS06780	COG1970	mechanosensitive ion channel activity
JGZ50_RS06790	COG0420	3'-5' exonuclease activity
JGZ50_RS06795	COG4846	Membrane protein involved in cytochrome C biogenesis
JGZ50_RS06800	COG3763	UPF0154 protein
JGZ50_RS06810	COG4224	UPF0291 protein
JGZ50_RS06820	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JGZ50_RS06830	COG0516	GMP reductase activity
JGZ50_RS06835	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JGZ50_RS06845	COG0833	amino acid
JGZ50_RS06860	COG0083	homoserine kinase activity
JGZ50_RS06865	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JGZ50_RS06870	COG0460	homoserine dehydrogenase
JGZ50_RS06875	COG0527	aspartate kinase activity
JGZ50_RS06895	COG1525	nuclease
JGZ50_RS06925	COG0584	glycerophosphoryl diester phosphodiesterase
JGZ50_RS06975	COG0789	Transcriptional regulator
JGZ50_RS06980	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
JGZ50_RS06985	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JGZ50_RS06990	COG0386	Belongs to the glutathione peroxidase family
JGZ50_RS06995	COG2267	carboxylic ester hydrolase activity
JGZ50_RS07000	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JGZ50_RS07005	COG1923	regulation of RNA biosynthetic process
JGZ50_RS07010	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JGZ50_RS07020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JGZ50_RS07025	COG1619	proteins homologs of microcin C7 resistance protein MccF
JGZ50_RS07030	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
JGZ50_RS07035	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
JGZ50_RS07055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JGZ50_RS07065	COG1013	pyruvate-flavodoxin oxidoreductase activity
JGZ50_RS07070	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JGZ50_RS07070	COG0674	pyruvate-flavodoxin oxidoreductase activity
JGZ50_RS07075	COG1692	metallophosphoesterase
JGZ50_RS07095	COG1418	mRNA catabolic process
JGZ50_RS07100	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JGZ50_RS07105	COG1058	Belongs to the CinA family
JGZ50_RS07105	COG1546	Belongs to the CinA family
JGZ50_RS07125	COG0300	oxidoreductase activity
JGZ50_RS07130	COG0612	Peptidase, M16
JGZ50_RS07135	COG0612	Peptidase, M16
JGZ50_RS07140	COG2188	Transcriptional regulator
JGZ50_RS07155	COG1185	polyribonucleotide nucleotidyltransferase activity
JGZ50_RS07165	COG0196	riboflavin kinase activity
JGZ50_RS07170	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JGZ50_RS07175	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JGZ50_RS07185	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JGZ50_RS07190	COG1358	cellular component organization or biogenesis
JGZ50_RS07195	COG2740	Nucleic-acid-binding protein implicated in transcription termination
JGZ50_RS07200	COG0195	Participates in both transcription termination and antitermination
JGZ50_RS07205	COG0779	Required for maturation of 30S ribosomal subunits
JGZ50_RS07215	COG0442	prolyl-tRNA aminoacylation
JGZ50_RS07230	COG4589	Belongs to the CDS family
JGZ50_RS07235	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JGZ50_RS07240	COG0233	cytoplasmic translational termination
JGZ50_RS07245	COG0528	UMP kinase activity
JGZ50_RS07250	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JGZ50_RS07255	COG0052	Belongs to the universal ribosomal protein uS2 family
JGZ50_RS07260	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
JGZ50_RS07265	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
JGZ50_RS07270	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
JGZ50_RS07275	COG4974	Belongs to the 'phage' integrase family
JGZ50_RS07280	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
JGZ50_RS07290	COG0758	DNA mediated transformation
JGZ50_RS07300	COG0045	succinate-CoA ligase (ADP-forming) activity
JGZ50_RS07310	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JGZ50_RS07325	COG4485	Bacterial membrane protein, YfhO
JGZ50_RS07365	COG0336	Belongs to the RNA methyltransferase TrmD family
JGZ50_RS07370	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JGZ50_RS07375	COG0228	four-way junction DNA binding
JGZ50_RS07445	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JGZ50_RS07450	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
JGZ50_RS07455	COG0552	protein localization to endoplasmic reticulum
JGZ50_RS07460	COG1196	nuclear chromosome segregation
JGZ50_RS07465	COG0571	ribonuclease III activity
JGZ50_RS07470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JGZ50_RS07485	COG0416	fatty acid biosynthetic process
JGZ50_RS07490	COG1349	DNA-binding transcription factor activity
JGZ50_RS07500	COG1760	l-serine dehydratase
JGZ50_RS07505	COG1760	l-serine dehydratase
JGZ50_RS07515	COG1302	Protein conserved in bacteria
JGZ50_RS07530	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JGZ50_RS07535	COG1162	GTPase activity
JGZ50_RS07540	COG2124	cytochrome p450
JGZ50_RS07555	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JGZ50_RS07560	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JGZ50_RS07560	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JGZ50_RS07565	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JGZ50_RS07570	COG0242	peptide deformylase activity
JGZ50_RS07575	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JGZ50_RS07580	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JGZ50_RS07585	COG1758	RNA polymerase activity
JGZ50_RS07605	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JGZ50_RS07610	COG0284	orotidine-5'-phosphate decarboxylase activity
JGZ50_RS07615	COG0167	dihydroorotate dehydrogenase activity
JGZ50_RS07625	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JGZ50_RS07630	COG0505	Belongs to the CarA family
JGZ50_RS07650	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
JGZ50_RS07655	COG0564	pseudouridine synthase activity
JGZ50_RS07660	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JGZ50_RS07665	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JGZ50_RS07670	COG3599	regulation of cell shape
JGZ50_RS07685	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JGZ50_RS07690	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JGZ50_RS07700	COG4975	Glucose uptake
JGZ50_RS07705	COG1869	D-ribose catabolic process
JGZ50_RS07710	COG0762	integral membrane protein
JGZ50_RS07715	COG1799	cell septum assembly
JGZ50_RS07720	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JGZ50_RS07730	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JGZ50_RS07735	COG0849	cell division
JGZ50_RS07745	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JGZ50_RS07755	COG0768	penicillin binding
JGZ50_RS07760	COG4839	cell division protein FtsL
JGZ50_RS07770	COG2001	Belongs to the MraZ family
JGZ50_RS07775	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
JGZ50_RS07780	COG0454	-acetyltransferase
JGZ50_RS07785	COG1011	Hydrolase
JGZ50_RS07800	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JGZ50_RS07875	COG0739	heme binding
JGZ50_RS07945	COG4626	Terminase
JGZ50_RS07945	COG1802	Transcriptional regulator
JGZ50_RS07975	COG0756	dUTP diphosphatase activity
JGZ50_RS08030	COG0305	Participates in initiation and elongation during chromosome replication
JGZ50_RS08125	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JGZ50_RS08150	COG0582	viral genome integration into host DNA
JGZ50_RS08225	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JGZ50_RS08230	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JGZ50_RS08235	COG1053	succinate dehydrogenase
JGZ50_RS08240	COG2009	succinate dehydrogenase
JGZ50_RS08245	COG0322	excinuclease ABC activity
JGZ50_RS08255	COG1193	negative regulation of DNA recombination
JGZ50_RS08260	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JGZ50_RS08260	COG1796	DNA polymerase
JGZ50_RS08295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JGZ50_RS08300	COG0333	Belongs to the bacterial ribosomal protein bL32 family
JGZ50_RS08320	COG0742	ribosomal rna small subunit methyltransferase
JGZ50_RS08330	COG4471	UPF0298 protein
JGZ50_RS08335	COG0584	glycerophosphoryl diester phosphodiesterase
JGZ50_RS08340	COG3679	Belongs to the UPF0342 family
JGZ50_RS08355	COG0109	protoheme IX farnesyltransferase activity
JGZ50_RS08375	COG0772	Belongs to the SEDS family
JGZ50_RS08380	COG4838	Belongs to the UPF0358 family
JGZ50_RS08385	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
JGZ50_RS08390	COG4896	Protein conserved in bacteria
JGZ50_RS08395	COG1902	pentaerythritol trinitrate reductase activity
JGZ50_RS08400	COG1217	gtp-binding protein TYPA
JGZ50_RS08410	COG0483	inositol monophosphate 1-phosphatase activity
JGZ50_RS08415	COG4493	Belongs to the UPF0637 family
JGZ50_RS08430	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
JGZ50_RS08435	COG1177	transmembrane transport
JGZ50_RS08445	COG3842	ATPase activity
JGZ50_RS08495	COG5503	Protein of unknown function (DUF1447)
JGZ50_RS08500	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
JGZ50_RS08505	COG0569	domain protein
JGZ50_RS08510	COG1294	oxidase, subunit
JGZ50_RS08515	COG1271	oxidase subunit
JGZ50_RS08520	COG1393	Belongs to the ArsC family
JGZ50_RS08525	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JGZ50_RS08530	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JGZ50_RS08540	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JGZ50_RS08560	COG4172	Belongs to the ABC transporter superfamily
JGZ50_RS08570	COG0151	Belongs to the GarS family
JGZ50_RS08575	COG0138	bifunctional purine biosynthesis protein purh
JGZ50_RS08585	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JGZ50_RS08590	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
JGZ50_RS08600	COG0047	phosphoribosylformylglycinamidine synthase activity
JGZ50_RS08605	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JGZ50_RS08610	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JGZ50_RS08615	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
JGZ50_RS08620	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JGZ50_RS08625	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JGZ50_RS08630	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JGZ50_RS08630	COG1017	nitric oxide dioxygenase activity
JGZ50_RS08640	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JGZ50_RS08650	COG1845	cytochrome c oxidase, subunit III
JGZ50_RS08655	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
JGZ50_RS08665	COG3212	peptidase
JGZ50_RS08680	COG1134	teichoic acid transport
JGZ50_RS08690	COG1682	transport, permease protein
JGZ50_RS08700	COG1215	transferase activity, transferring glycosyl groups
JGZ50_RS08710	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
JGZ50_RS08715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JGZ50_RS08720	COG1316	TRANSCRIPTIONal
JGZ50_RS08745	COG3594	Acyltransferase
JGZ50_RS08750	COG0436	Aminotransferase
JGZ50_RS08755	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
JGZ50_RS08765	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
JGZ50_RS08775	COG1575	Belongs to the MenA family. Type 1 subfamily
JGZ50_RS08780	COG0390	transport system, permease component
JGZ50_RS08785	COG4619	ABC transporter
JGZ50_RS08795	COG3682	Transcriptional regulator
JGZ50_RS08825	COG4974	Belongs to the 'phage' integrase family
JGZ50_RS08845	COG4873	Protein conserved in bacteria
JGZ50_RS08880	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
JGZ50_RS08880	COG3266	domain, Protein
JGZ50_RS08880	COG4932	domain protein
JGZ50_RS08895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JGZ50_RS08900	COG1696	Membrane protein involved in D-alanine export
JGZ50_RS08910	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
JGZ50_RS08915	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JGZ50_RS08920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JGZ50_RS08925	COG0861	Integral membrane protein TerC family
JGZ50_RS08930	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
JGZ50_RS08940	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JGZ50_RS08945	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JGZ50_RS08950	COG2814	Major facilitator Superfamily
JGZ50_RS08960	COG3715	PTS system
JGZ50_RS08965	COG3716	PTS system mannose fructose sorbose family IID component
JGZ50_RS08970	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
JGZ50_RS08975	COG2382	esterase
JGZ50_RS08980	COG1115	amino acid carrier protein
JGZ50_RS08985	COG0628	permease
JGZ50_RS08990	COG4409	exo-alpha-(2->6)-sialidase activity
JGZ50_RS08995	COG2211	Major facilitator Superfamily
JGZ50_RS09000	COG0673	inositol 2-dehydrogenase activity
JGZ50_RS09010	COG0475	glutathione-regulated potassium exporter activity
JGZ50_RS09010	COG0569	domain protein
JGZ50_RS09015	COG2239	Acts as a magnesium transporter
JGZ50_RS09020	COG0564	pseudouridine synthase activity
JGZ50_RS09030	COG2357	RelA SpoT domain protein
JGZ50_RS09045	COG2346	COG2346, Truncated hemoglobins
JGZ50_RS09050	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
JGZ50_RS09060	COG1164	Oligoendopeptidase f
JGZ50_RS09085	COG1393	Belongs to the ArsC family
JGZ50_RS09090	COG0180	Tryptophanyl-tRNA synthetase
JGZ50_RS09095	COG4166	transmembrane transport
JGZ50_RS09100	COG4608	Belongs to the ABC transporter superfamily
JGZ50_RS09105	COG0444	Belongs to the ABC transporter superfamily
JGZ50_RS09110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JGZ50_RS09115	COG0601	transmembrane transport
JGZ50_RS09140	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
JGZ50_RS09160	COG0561	phosphatase activity
JGZ50_RS09165	COG0446	pyridine nucleotide-disulphide oxidoreductase
JGZ50_RS09175	COG0179	Fumarylacetoacetate (FAA) hydrolase
JGZ50_RS09185	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
JGZ50_RS09200	COG0166	Belongs to the GPI family
JGZ50_RS09205	COG0137	argininosuccinate synthase activity
JGZ50_RS09215	COG0584	glycerophosphoryl diester phosphodiesterase
JGZ50_RS09230	COG1012	belongs to the aldehyde dehydrogenase family
JGZ50_RS09235	COG1098	S1 RNA binding domain
JGZ50_RS09245	COG1278	Cold shock
JGZ50_RS09260	COG1131	(ABC) transporter
JGZ50_RS09290	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JGZ50_RS09300	COG2111	Na H antiporter
JGZ50_RS09300	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JGZ50_RS09305	COG2111	Na H antiporter
JGZ50_RS09310	COG1006	Multisubunit Na H antiporter MnhC subunit
JGZ50_RS09315	COG0651	ATP synthesis coupled electron transport
JGZ50_RS09320	COG1863	multisubunit Na H antiporter MnhE subunit
JGZ50_RS09325	COG2212	antiporter activity
JGZ50_RS09330	COG1320	monovalent cation:proton antiporter activity
JGZ50_RS09340	COG2056	Na+-H+ antiporter family
JGZ50_RS09345	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JGZ50_RS09350	COG1252	NADH dehydrogenase
JGZ50_RS09355	COG0316	Belongs to the HesB IscA family
JGZ50_RS09360	COG4844	belongs to the
JGZ50_RS09365	COG1252	NADH dehydrogenase
JGZ50_RS09370	COG4837	Protein of unknown function (DUF1462)
JGZ50_RS09375	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
JGZ50_RS09380	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JGZ50_RS09385	COG0647	UMP catabolic process
JGZ50_RS09390	COG2445	Protein of unknown function DUF86
JGZ50_RS09400	COG4470	Protein conserved in bacteria
JGZ50_RS09405	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JGZ50_RS09410	COG0737	Belongs to the 5'-nucleotidase family
JGZ50_RS09415	COG0730	response to heat
JGZ50_RS09420	COG1801	Protein of unknown function DUF72
JGZ50_RS09435	COG4536	flavin adenine dinucleotide binding
JGZ50_RS09445	COG0719	Fe-S assembly protein
JGZ50_RS09450	COG0822	iron-sulfur transferase activity
JGZ50_RS09465	COG0396	ATPase activity
JGZ50_RS09475	COG1464	Belongs to the NlpA lipoprotein family
JGZ50_RS09480	COG1464	Belongs to the NlpA lipoprotein family
JGZ50_RS09485	COG2011	ABC-type metal ion transport system permease component
JGZ50_RS09495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JGZ50_RS09500	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
JGZ50_RS09510	COG1393	Belongs to the ArsC family
JGZ50_RS09515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JGZ50_RS09525	COG0710	3-dehydroquinate dehydratase activity
JGZ50_RS09535	COG1764	response to oxidative stress
JGZ50_RS09550	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JGZ50_RS09570	COG0346	lactoylglutathione lyase activity
JGZ50_RS09610	COG0557	exoribonuclease II activity
JGZ50_RS09615	COG1647	Serine aminopeptidase, S33
JGZ50_RS09620	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JGZ50_RS09630	COG0148	phosphopyruvate hydratase activity
JGZ50_RS09635	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
JGZ50_RS09665	COG1090	epimerase
JGZ50_RS09675	COG0740	serine-type endopeptidase activity
JGZ50_RS09685	COG1481	regulation of sporulation
JGZ50_RS09690	COG0391	Required for morphogenesis under gluconeogenic growth conditions
JGZ50_RS09695	COG1660	Displays ATPase and GTPase activities
JGZ50_RS09710	COG0110	maltose O-acetyltransferase activity
JGZ50_RS09715	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JGZ50_RS09720	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
JGZ50_RS09755	COG0653	protein targeting
JGZ50_RS09770	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
JGZ50_RS09785	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JGZ50_RS09805	COG2195	Cleaves the N-terminal amino acid of tripeptides
JGZ50_RS09815	COG1929	Belongs to the glycerate kinase type-1 family
JGZ50_RS09820	COG3118	belongs to the thioredoxin family
JGZ50_RS09835	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JGZ50_RS09845	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JGZ50_RS09850	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JGZ50_RS09900	COG2801	Transposase and inactivated derivatives
JGZ50_RS09915	COG3104	oligopeptide transport
JGZ50_RS09920	COG3104	oligopeptide transport
JGZ50_RS09935	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JGZ50_RS09940	COG1174	glycine betaine transport
JGZ50_RS09945	COG0517	IMP dehydrogenase activity
JGZ50_RS09945	COG1125	glycine betaine transport
JGZ50_RS09950	COG0514	ATP-dependent DNA helicase (RecQ)
JGZ50_RS09955	COG0488	(ABC) transporter
JGZ50_RS09965	COG2274	protein secretion by the type I secretion system
JGZ50_RS09970	COG2274	protein secretion by the type I secretion system
JGZ50_RS09990	COG0463	Glycosyl transferase, family 2
JGZ50_RS09995	COG1368	sulfuric ester hydrolase activity
JGZ50_RS10005	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JGZ50_RS10025	COG0512	Glutamine amidotransferase of anthranilate synthase
JGZ50_RS10035	COG0720	synthase
JGZ50_RS10040	COG0602	queuosine metabolic process
JGZ50_RS10055	COG0463	Glycosyl transferase, family 2
JGZ50_RS10060	COG1253	flavin adenine dinucleotide binding
JGZ50_RS10065	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JGZ50_RS10065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JGZ50_RS10065	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JGZ50_RS10070	COG1105	Belongs to the carbohydrate kinase PfkB family
JGZ50_RS10075	COG1349	DNA-binding transcription factor activity
JGZ50_RS10095	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JGZ50_RS10100	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JGZ50_RS10120	COG0039	L-malate dehydrogenase activity
JGZ50_RS10150	COG4989	oxidoreductase activity
JGZ50_RS10165	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
JGZ50_RS10170	COG4988	ABC transporter
JGZ50_RS10175	COG1968	undecaprenyl-diphosphatase activity
JGZ50_RS10185	COG1671	Belongs to the UPF0178 family
JGZ50_RS10190	COG1611	Belongs to the LOG family
JGZ50_RS10220	COG2839	Protein conserved in bacteria
JGZ50_RS10225	COG2814	Major facilitator Superfamily
JGZ50_RS10230	COG0583	DNA-binding transcription factor activity
JGZ50_RS10245	COG0217	transcriptional regulatory protein
JGZ50_RS10250	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JGZ50_RS10265	COG0352	thiamine-phosphate diphosphorylase activity
JGZ50_RS10275	COG3942	CHAP domain
JGZ50_RS10275	COG1388	LysM domain
JGZ50_RS10280	COG0306	phosphate transporter
JGZ50_RS10285	COG1392	Phosphate transport regulator
JGZ50_RS10290	COG0577	efflux transmembrane transporter activity
JGZ50_RS10295	COG1136	(ABC) transporter
JGZ50_RS10305	COG0745	RESPONSE REGULATOR receiver
JGZ50_RS10310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JGZ50_RS10315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JGZ50_RS10325	COG3949	Membrane
JGZ50_RS10330	COG0477	Major facilitator Superfamily
JGZ50_RS10340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JGZ50_RS10345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JGZ50_RS10350	COG1120	ATPase activity
JGZ50_RS10355	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JGZ50_RS10360	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JGZ50_RS10380	COG1132	(ABC) transporter
JGZ50_RS10385	COG1686	Belongs to the peptidase S11 family
JGZ50_RS10400	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
JGZ50_RS10405	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JGZ50_RS10410	COG1682	transport, permease protein
JGZ50_RS10420	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
JGZ50_RS10435	COG1475	DNA binding
JGZ50_RS10450	COG4264	IucA IucC family
JGZ50_RS10455	COG4264	IucA IucC family
JGZ50_RS10460	COG2814	Major facilitator Superfamily
JGZ50_RS10465	COG4264	IucA IucC family
JGZ50_RS10470	COG2423	ornithine cyclodeaminase activity
JGZ50_RS10480	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JGZ50_RS10485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JGZ50_RS10490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JGZ50_RS10500	COG1121	(ABC) transporter
JGZ50_RS10505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JGZ50_RS10510	COG0803	Belongs to the bacterial solute-binding protein 9 family
JGZ50_RS10515	COG1320	monovalent cation:proton antiporter activity
JGZ50_RS10520	COG2212	antiporter activity
JGZ50_RS10525	COG1863	multisubunit Na H antiporter MnhE subunit
JGZ50_RS10535	COG1006	Multisubunit Na H antiporter MnhC subunit
JGZ50_RS10540	COG2111	Na H antiporter
JGZ50_RS10545	COG2111	Na H antiporter
JGZ50_RS10545	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JGZ50_RS10595	COG0546	phosphoglycolate phosphatase activity
JGZ50_RS10600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JGZ50_RS10605	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JGZ50_RS10610	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JGZ50_RS10615	COG0805	protein transport
JGZ50_RS10620	COG0018	arginyl-trna synthetase
JGZ50_RS10635	COG1078	dGTPase activity
JGZ50_RS10645	COG4844	belongs to the
JGZ50_RS10710	COG1695	Transcriptional regulator
JGZ50_RS10715	COG0471	metal ion transport
JGZ50_RS10740	COG0280	phosphate acetyltransferase
JGZ50_RS10745	COG0095	Lipoate-protein ligase
JGZ50_RS10765	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JGZ50_RS10770	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
JGZ50_RS10780	COG2814	Major facilitator Superfamily
JGZ50_RS10785	COG1566	PFAM secretion protein HlyD family protein
JGZ50_RS10795	COG2311	Membrane
JGZ50_RS10830	COG2363	Small membrane protein
JGZ50_RS10860	COG0183	Belongs to the thiolase family
JGZ50_RS10865	COG0318	PFAM AMP-dependent synthetase and ligase
JGZ50_RS10870	COG0588	phosphoglycerate mutase activity
JGZ50_RS10875	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JGZ50_RS10885	COG2814	Major facilitator Superfamily
JGZ50_RS10895	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JGZ50_RS10905	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
JGZ50_RS10920	COG1263	PTS System
JGZ50_RS10920	COG2190	(PTS) system
JGZ50_RS10920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JGZ50_RS10935	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JGZ50_RS10940	COG1469	GTP cyclohydrolase I activity
JGZ50_RS10965	COG0561	phosphatase activity
JGZ50_RS10975	COG1428	Deoxynucleoside kinase
JGZ50_RS10980	COG1428	Deoxynucleoside kinase
JGZ50_RS10985	COG0546	phosphoglycolate phosphatase activity
JGZ50_RS11015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JGZ50_RS11025	COG1473	amidohydrolase
JGZ50_RS11030	COG3527	Alpha-acetolactate decarboxylase
JGZ50_RS11035	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JGZ50_RS11040	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JGZ50_RS11045	COG0049	tRNA binding
JGZ50_RS11050	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JGZ50_RS11060	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JGZ50_RS11065	COG0085	RNA polymerase activity
JGZ50_RS11080	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JGZ50_RS11085	COG0081	regulation of translation
JGZ50_RS11090	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JGZ50_RS11095	COG0250	Participates in transcription elongation, termination and antitermination
JGZ50_RS11100	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JGZ50_RS11105	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JGZ50_RS11125	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
JGZ50_RS11130	COG0215	cysteine-tRNA ligase activity
JGZ50_RS11135	COG1045	serine acetyltransferase
JGZ50_RS11140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JGZ50_RS11155	COG4956	integral membrane protein (PIN domain superfamily)
JGZ50_RS11160	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JGZ50_RS11195	COG0542	response to heat
JGZ50_RS11200	COG3869	Catalyzes the specific phosphorylation of arginine residues in
JGZ50_RS11205	COG3880	PFAM UvrB UvrC protein
JGZ50_RS11215	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JGZ50_RS11225	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
JGZ50_RS11230	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
JGZ50_RS11235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JGZ50_RS11240	COG1289	transmembrane transporter activity
JGZ50_RS11330	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JGZ50_RS11335	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JGZ50_RS11355	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
JGZ50_RS11360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JGZ50_RS11375	COG1098	S1 RNA binding domain
JGZ50_RS11385	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
JGZ50_RS11390	COG3956	TIGRFAM MazG family protein
JGZ50_RS11395	COG2244	polysaccharide biosynthetic process
JGZ50_RS11400	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JGZ50_RS11405	COG0193	aminoacyl-tRNA hydrolase activity
JGZ50_RS11415	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JGZ50_RS11420	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JGZ50_RS11425	COG2088	sporulation resulting in formation of a cellular spore
JGZ50_RS11430	COG0251	oxidation-reduction process
JGZ50_RS11435	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JGZ50_RS11440	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JGZ50_RS11445	COG4466	Protein conserved in bacteria
JGZ50_RS11455	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
JGZ50_RS11460	COG0084	hydrolase, TatD family'
JGZ50_RS11470	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
JGZ50_RS11475	COG2827	Endonuclease containing a URI domain
JGZ50_RS11480	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
JGZ50_RS11485	COG4467	Involved in initiation control of chromosome replication
JGZ50_RS11490	COG1774	PSP1 C-terminal conserved region
JGZ50_RS11495	COG0470	DNA polymerase III
JGZ50_RS11500	COG3870	Protein conserved in bacteria
JGZ50_RS11505	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JGZ50_RS11510	COG1982	Orn Lys Arg decarboxylase major
JGZ50_RS11530	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JGZ50_RS11535	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JGZ50_RS11540	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JGZ50_RS11545	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JGZ50_RS11555	COG2188	Transcriptional regulator
JGZ50_RS11560	COG0366	Alpha amylase catalytic
JGZ50_RS11565	COG1263	PTS System
JGZ50_RS11565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JGZ50_RS11575	COG0493	'glutamate synthase
JGZ50_RS11580	COG0067	glutamate synthase
JGZ50_RS11580	COG0069	glutamate synthase activity
JGZ50_RS11580	COG0070	glutamate synthase
JGZ50_RS11585	COG0583	DNA-binding transcription factor activity
JGZ50_RS11600	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JGZ50_RS11615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JGZ50_RS11625	COG0535	radical SAM domain protein
JGZ50_RS11635	COG1131	(ABC) transporter
JGZ50_RS11680	COG0626	cystathionine gamma-synthase activity
JGZ50_RS11685	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JGZ50_RS11690	COG2272	Belongs to the type-B carboxylesterase lipase family
JGZ50_RS11695	COG0733	neurotransmitter:sodium symporter activity
JGZ50_RS11710	COG0745	RESPONSE REGULATOR receiver
JGZ50_RS11715	COG2205	protein histidine kinase activity
JGZ50_RS11725	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
JGZ50_RS11730	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
JGZ50_RS11745	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JGZ50_RS11750	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JGZ50_RS11750	COG0574	Belongs to the PEP-utilizing enzyme family
JGZ50_RS11780	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
JGZ50_RS11790	COG1486	melibiose metabolic process
JGZ50_RS11795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JGZ50_RS11795	COG1263	PTS System
JGZ50_RS11815	COG2210	Belongs to the sulfur carrier protein TusA family
JGZ50_RS11820	COG1937	Protein conserved in bacteria
JGZ50_RS11825	COG0730	response to heat
JGZ50_RS11830	COG2814	Major facilitator Superfamily
JGZ50_RS11845	COG1124	(ABC) transporter
JGZ50_RS11850	COG0444	Belongs to the ABC transporter superfamily
JGZ50_RS11855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JGZ50_RS11860	COG0601	transmembrane transport
JGZ50_RS11865	COG0747	negative chemotaxis
JGZ50_RS11890	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
JGZ50_RS11910	COG1525	nuclease
JGZ50_RS11930	COG3344	reverse transcriptase
JGZ50_RS11955	COG0582	viral genome integration into host DNA
JGZ50_RS12040	COG0582	viral genome integration into host DNA
JGZ50_RS12050	COG0519	Catalyzes the synthesis of GMP from XMP
JGZ50_RS12050	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JGZ50_RS12055	COG0517	IMP dehydrogenase activity
JGZ50_RS12055	COG0516	GMP reductase activity
JGZ50_RS12060	COG2233	PERMEase
JGZ50_RS12065	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JGZ50_RS12080	COG5183	chlorophyll binding
JGZ50_RS12085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JGZ50_RS12090	COG1823	symporter activity
JGZ50_RS12095	COG0577	efflux transmembrane transporter activity
JGZ50_RS12095	COG1136	(ABC) transporter
JGZ50_RS12110	COG0778	Nitroreductase
JGZ50_RS12115	COG0450	alkyl hydroperoxide reductase
JGZ50_RS12130	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JGZ50_RS12140	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JGZ50_RS12145	COG2011	ABC-type metal ion transport system permease component
JGZ50_RS12150	COG1464	Belongs to the NlpA lipoprotein family
JGZ50_RS12155	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JGZ50_RS12160	COG0753	catalase activity
JGZ50_RS12170	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JGZ50_RS12180	COG0360	Binds together with S18 to 16S ribosomal RNA
JGZ50_RS12190	COG1668	transmembrane transport
JGZ50_RS12195	COG1131	(ABC) transporter
JGZ50_RS12215	COG4481	Protein conserved in bacteria
JGZ50_RS12220	COG0668	transmembrane transport
JGZ50_RS12225	COG1475	DNA binding
JGZ50_RS12230	COG0626	cystathionine gamma-synthase activity
JGZ50_RS12235	COG0626	cystathionine gamma-synthase activity
JGZ50_RS12240	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
JGZ50_RS12240	COG0646	methionine synthase
JGZ50_RS12250	COG0829	nickel cation binding
JGZ50_RS12260	COG0830	nickel cation binding
JGZ50_RS12265	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
JGZ50_RS12275	COG2388	GCN5-related N-acetyl-transferase
JGZ50_RS12280	COG1846	Transcriptional regulator
JGZ50_RS12285	COG0346	lactoylglutathione lyase activity
JGZ50_RS12290	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JGZ50_RS12295	COG0400	carboxylic ester hydrolase activity
JGZ50_RS12320	COG0357	Ribosomal RNA small subunit methyltransferase G
JGZ50_RS12325	COG0445	tRNA wobble uridine modification
JGZ50_RS12330	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
JGZ50_RS12335	COG0594	ribonuclease P activity