locus-tag	class	description
SPSE_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SPSE_RS00010	COG0592	DNA-directed DNA polymerase activity
SPSE_RS00015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
SPSE_RS00015	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
SPSE_RS00020	COG2501	S4 domain
SPSE_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SPSE_RS00030	COG0187	DNA topoisomerase II activity
SPSE_RS00040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SPSE_RS00045	COG2986	histidine ammonia-lyase
SPSE_RS00055	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
SPSE_RS00065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SPSE_RS00070	COG4241	membrane
SPSE_RS00075	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
SPSE_RS00080	COG0359	binds to the 23S rRNA
SPSE_RS00085	COG0305	Participates in initiation and elongation during chromosome replication
SPSE_RS00090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SPSE_RS00095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPSE_RS00115	COG0745	RESPONSE REGULATOR receiver
SPSE_RS00120	COG5002	protein histidine kinase activity
SPSE_RS00125	COG4863	YycH protein
SPSE_RS00135	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPSE_RS00160	COG2311	Membrane
SPSE_RS00180	COG0531	amino acid
SPSE_RS00185	COG2217	Heavy metal translocating P-type atpase
SPSE_RS00200	COG3655	Transcriptional regulator
SPSE_RS00215	COG2188	Transcriptional regulator
SPSE_RS00220	COG2723	6-phospho-beta-galactosidase activity
SPSE_RS00230	COG0415	Belongs to the DNA photolyase family
SPSE_RS00245	COG0702	epimerase
SPSE_RS00250	COG2130	NADP-dependent
SPSE_RS00260	COG3177	Filamentation induced by cAMP protein fic
SPSE_RS00265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPSE_RS00270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPSE_RS00270	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SPSE_RS00275	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SPSE_RS00280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPSE_RS00300	COG2235	arginine
SPSE_RS00330	COG0431	NADPH-dependent FMN reductase
SPSE_RS00335	COG4932	domain protein
SPSE_RS00335	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
SPSE_RS00335	COG3583	domain protein
SPSE_RS00370	COG1609	Transcriptional regulator
SPSE_RS00380	COG0673	inositol 2-dehydrogenase activity
SPSE_RS00390	COG0366	Alpha amylase catalytic
SPSE_RS00400	COG3833	ABC-type maltose transport systems, permease component
SPSE_RS00405	COG1175	transmembrane transport
SPSE_RS00415	COG3842	ATPase activity
SPSE_RS00420	COG0475	glutathione-regulated potassium exporter activity
SPSE_RS00425	COG0490	domain, Protein
SPSE_RS00435	COG0346	lactoylglutathione lyase activity
SPSE_RS00460	COG1131	(ABC) transporter
SPSE_RS00475	COG0366	Alpha amylase catalytic
SPSE_RS00475	COG0366	Alpha amylase catalytic
SPSE_RS00480	COG2188	Transcriptional regulator
SPSE_RS00485	COG2222	sugar isomerase
SPSE_RS00490	COG1105	Belongs to the carbohydrate kinase PfkB family
SPSE_RS00505	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPSE_RS00505	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPSE_RS00510	COG3715	PTS system
SPSE_RS00515	COG3716	PTS system mannose fructose sorbose family IID component
SPSE_RS00525	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SPSE_RS00545	COG3314	Sporulation integral membrane protein YlbJ
SPSE_RS00565	COG1063	alcohol dehydrogenase
SPSE_RS00580	COG1620	l-lactate permease
SPSE_RS00585	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SPSE_RS00590	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SPSE_RS00595	COG0156	8-amino-7-oxononanoate synthase activity
SPSE_RS00640	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SPSE_RS00655	COG0076	glutamate decarboxylase activity
SPSE_RS00670	COG2318	DinB family
SPSE_RS00675	COG0753	catalase activity
SPSE_RS00685	COG0783	Belongs to the Dps family
SPSE_RS00695	COG0436	Aminotransferase
SPSE_RS00720	COG1136	(ABC) transporter
SPSE_RS00730	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPSE_RS00735	COG3344	reverse transcriptase
SPSE_RS00750	COG1755	Isoprenylcysteine carboxyl methyltransferase
SPSE_RS00770	COG0579	oxidoreductase
SPSE_RS00790	COG1073	alpha beta
SPSE_RS00810	COG0438	transferase activity, transferring glycosyl groups
SPSE_RS00815	COG0183	Belongs to the thiolase family
SPSE_RS00825	COG1960	acyl-CoA dehydrogenase activity
SPSE_RS00830	COG0318	PFAM AMP-dependent synthetase and ligase
SPSE_RS00840	COG2814	Major facilitator Superfamily
SPSE_RS00850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SPSE_RS00880	COG1609	Transcriptional regulator
SPSE_RS00885	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SPSE_RS00890	COG1869	D-ribose catabolic process
SPSE_RS00915	COG3711	transcriptional antiterminator
SPSE_RS00920	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPSE_RS00930	COG3037	sugar-specific permease SgaT UlaA
SPSE_RS00935	COG1328	CTP reductase activity
SPSE_RS00955	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPSE_RS00960	COG1942	4-Oxalocrotonate Tautomerase
SPSE_RS00970	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPSE_RS00970	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPSE_RS00995	COG2207	Transcriptional regulator
SPSE_RS00995	COG4753	response regulator
SPSE_RS01000	COG2972	Histidine kinase
SPSE_RS01010	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SPSE_RS01015	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
SPSE_RS01020	COG0477	Major facilitator Superfamily
SPSE_RS01025	COG2211	Major facilitator Superfamily
SPSE_RS01030	COG3250	beta-galactosidase activity
SPSE_RS01035	COG1957	nucleoside hydrolase
SPSE_RS01050	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SPSE_RS01055	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
SPSE_RS01060	COG2807	transmembrane transport
SPSE_RS01065	COG1396	sequence-specific DNA binding
SPSE_RS01080	COG1785	Belongs to the alkaline phosphatase family
SPSE_RS01085	COG0494	nUDIX hydrolase
SPSE_RS01090	COG0556	nucleotide-excision repair
SPSE_RS01105	COG1510	regulation of RNA biosynthetic process
SPSE_RS01110	COG1012	belongs to the aldehyde dehydrogenase family
SPSE_RS01115	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SPSE_RS01120	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SPSE_RS01130	COG0107	imidazoleglycerol-phosphate synthase activity
SPSE_RS01135	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SPSE_RS01150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SPSE_RS01155	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SPSE_RS01160	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SPSE_RS01165	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SPSE_RS01205	COG2376	Dihydroxyacetone kinase
SPSE_RS01210	COG1461	Dihydroxyacetone kinase
SPSE_RS01215	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SPSE_RS01220	COG2824	Alkylphosphonate utilization operon protein PhnA
SPSE_RS01225	COG1012	belongs to the aldehyde dehydrogenase family
SPSE_RS01240	COG0596	Alpha beta hydrolase
SPSE_RS01245	COG0789	Transcriptional regulator
SPSE_RS01250	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPSE_RS01250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPSE_RS01250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPSE_RS01260	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPSE_RS01260	COG3942	CHAP domain
SPSE_RS01270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SPSE_RS01275	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SPSE_RS01280	COG0747	negative chemotaxis
SPSE_RS01305	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SPSE_RS01305	COG0463	Glycosyl transferase, family 2
SPSE_RS01310	COG0463	Glycosyl transferase, family 2
SPSE_RS01310	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SPSE_RS01315	COG0438	transferase activity, transferring glycosyl groups
SPSE_RS01320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SPSE_RS01340	COG3181	Tripartite tricarboxylate transporter family receptor
SPSE_RS01345	COG0778	Nitroreductase
SPSE_RS01350	COG3001	Fructosamine kinase
SPSE_RS01375	COG1136	(ABC) transporter
SPSE_RS01380	COG0577	efflux transmembrane transporter activity
SPSE_RS01400	COG4413	Urea transporter
SPSE_RS01410	COG0832	Belongs to the urease beta subunit family
SPSE_RS01415	COG0804	urea catabolic process
SPSE_RS01420	COG0717	Belongs to the dCTP deaminase family
SPSE_RS01425	COG0523	cobalamin synthesis protein
SPSE_RS01435	COG1141	Ferredoxin
SPSE_RS01460	COG0583	DNA-binding transcription factor activity
SPSE_RS01470	COG1346	cytolysis
SPSE_RS01485	COG1846	Transcriptional regulator
SPSE_RS01490	COG0778	Nitroreductase
SPSE_RS01495	COG2357	RelA SpoT domain protein
SPSE_RS01535	COG1028	Short-chain dehydrogenase reductase Sdr
SPSE_RS01550	COG3835	regulator
SPSE_RS01555	COG2855	membrane
SPSE_RS01560	COG3961	Belongs to the TPP enzyme family
SPSE_RS01565	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPSE_RS01570	COG0512	Glutamine amidotransferase of anthranilate synthase
SPSE_RS01580	COG0134	indole-3-glycerol-phosphate synthase activity
SPSE_RS01590	COG0133	tryptophan synthase activity
SPSE_RS01595	COG0159	tryptophan synthase activity
SPSE_RS01615	COG0277	FAD linked oxidase domain protein
SPSE_RS01620	COG0247	lactate metabolic process
SPSE_RS01625	COG1132	(ABC) transporter
SPSE_RS01630	COG1132	(ABC) transporter
SPSE_RS01635	COG0789	Transcriptional regulator
SPSE_RS01645	COG3871	stress protein (general stress protein 26)
SPSE_RS01650	COG1115	amino acid carrier protein
SPSE_RS01655	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
SPSE_RS01660	COG2814	Major facilitator Superfamily
SPSE_RS01665	COG2271	Major facilitator Superfamily
SPSE_RS01670	COG3764	Sortase (surface protein transpeptidase)
SPSE_RS01675	COG1929	Belongs to the glycerate kinase type-1 family
SPSE_RS01685	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
SPSE_RS01705	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPSE_RS01710	COG0702	epimerase
SPSE_RS01715	COG4166	transmembrane transport
SPSE_RS01720	COG0444	Belongs to the ABC transporter superfamily
SPSE_RS01725	COG4608	Belongs to the ABC transporter superfamily
SPSE_RS01730	COG0601	transmembrane transport
SPSE_RS01735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPSE_RS01740	COG4166	transmembrane transport
SPSE_RS01745	COG0444	Belongs to the ABC transporter superfamily
SPSE_RS01750	COG4608	Belongs to the ABC transporter superfamily
SPSE_RS01755	COG0601	transmembrane transport
SPSE_RS01760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPSE_RS01770	COG1760	l-serine dehydratase
SPSE_RS01775	COG1760	l-serine dehydratase
SPSE_RS01830	COG0471	metal ion transport
SPSE_RS01835	COG2116	formate transmembrane transporter activity
SPSE_RS01840	COG0454	-acetyltransferase
SPSE_RS01850	COG1648	precorrin-2 dehydrogenase activity
SPSE_RS01850	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SPSE_RS01855	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SPSE_RS01860	COG2146	nitrite reductase [NAD(P)H] activity
SPSE_RS01865	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SPSE_RS01865	COG1648	precorrin-2 dehydrogenase activity
SPSE_RS01905	COG0018	arginyl-trna synthetase
SPSE_RS01915	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
SPSE_RS01920	COG1140	nitrate reductase beta subunit
SPSE_RS01930	COG2181	nitrate reductase activity
SPSE_RS01940	COG4585	Histidine kinase
SPSE_RS01945	COG2197	response regulator
SPSE_RS01950	COG2223	nitrite transmembrane transporter activity
SPSE_RS01955	COG4187	Peptidase family M20/M25/M40
SPSE_RS01965	COG0039	L-malate dehydrogenase activity
SPSE_RS01970	COG1363	Peptidase, m42
SPSE_RS01975	COG0697	spore germination
SPSE_RS01985	COG2807	transmembrane transport
SPSE_RS01995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPSE_RS01995	COG1263	PTS System
SPSE_RS02010	COG1283	sodium-dependent phosphate transmembrane transporter activity
SPSE_RS02035	COG0492	ferredoxin-NADP+ reductase activity
SPSE_RS02040	COG2814	Major facilitator Superfamily
SPSE_RS02045	COG0604	alcohol dehydrogenase
SPSE_RS02060	COG1620	l-lactate permease
SPSE_RS02070	COG0438	transferase activity, transferring glycosyl groups
SPSE_RS02075	COG0579	oxidoreductase
SPSE_RS02090	COG0577	efflux transmembrane transporter activity
SPSE_RS02125	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SPSE_RS02135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPSE_RS02155	COG1304	FMN binding
SPSE_RS02160	COG0523	cobalamin synthesis protein
SPSE_RS02175	COG3328	transposase activity
SPSE_RS02180	COG0786	glutamate:sodium symporter activity
SPSE_RS02185	COG2207	Transcriptional regulator
SPSE_RS02190	COG3250	beta-galactosidase activity
SPSE_RS02210	COG1757	Na H antiporter
SPSE_RS02215	COG2094	Belongs to the DNA glycosylase MPG family
SPSE_RS02220	COG3152	Membrane
SPSE_RS02225	COG4152	abc transporter atp-binding protein
SPSE_RS02230	COG1668	transmembrane transport
SPSE_RS02235	COG1742	UPF0060 membrane protein
SPSE_RS02240	COG2017	converts alpha-aldose to the beta-anomer
SPSE_RS02245	COG2258	MOSC domain
SPSE_RS02250	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SPSE_RS02260	COG1266	CAAX protease self-immunity
SPSE_RS02265	COG0583	DNA-binding transcription factor activity
SPSE_RS02270	COG3314	Sporulation integral membrane protein YlbJ
SPSE_RS02275	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SPSE_RS02280	COG1228	amidohydrolase
SPSE_RS02285	COG0659	secondary active sulfate transmembrane transporter activity
SPSE_RS02290	COG1473	amidohydrolase
SPSE_RS02310	COG0385	Bile acid
SPSE_RS02320	COG0346	lactoylglutathione lyase activity
SPSE_RS02325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SPSE_RS02350	COG1113	amino acid transport
SPSE_RS02370	COG1316	TRANSCRIPTIONal
SPSE_RS02385	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SPSE_RS02390	COG3383	formate dehydrogenase (NAD+) activity
SPSE_RS02415	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SPSE_RS02420	COG2076	Multidrug Resistance protein
SPSE_RS02425	COG2076	Multidrug Resistance protein
SPSE_RS02430	COG3942	CHAP domain
SPSE_RS02440	COG1757	Na H antiporter
SPSE_RS02450	COG3942	CHAP domain
SPSE_RS02470	COG1960	acyl-CoA dehydrogenase activity
SPSE_RS02475	COG2832	Protein of unknown function (DUF454)
SPSE_RS02480	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SPSE_RS02485	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPSE_RS02495	COG2186	Transcriptional regulator
SPSE_RS02505	COG1268	BioY protein
SPSE_RS02520	COG1609	Transcriptional regulator
SPSE_RS02525	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SPSE_RS02530	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPSE_RS02535	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPSE_RS02545	COG4149	molybdate abc transporter
SPSE_RS02550	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SPSE_RS02555	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SPSE_RS02560	COG0521	Mo-molybdopterin cofactor biosynthetic process
SPSE_RS02580	COG0314	molybdopterin synthase activity
SPSE_RS02590	COG0746	molybdenum cofactor guanylyltransferase activity
SPSE_RS02595	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SPSE_RS02620	COG2348	transferase activity, transferring amino-acyl groups
SPSE_RS02625	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SPSE_RS02630	COG0436	Aminotransferase
SPSE_RS02650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPSE_RS02650	COG0551	DNA topoisomerase type I activity
SPSE_RS02655	COG2252	PERMEase
SPSE_RS02675	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SPSE_RS02680	COG0088	Forms part of the polypeptide exit tunnel
SPSE_RS02685	COG0089	rRNA binding
SPSE_RS02690	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SPSE_RS02695	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SPSE_RS02700	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SPSE_RS02705	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SPSE_RS02710	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SPSE_RS02715	COG0255	Belongs to the universal ribosomal protein uL29 family
SPSE_RS02725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SPSE_RS02740	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SPSE_RS02745	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SPSE_RS02750	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SPSE_RS02760	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SPSE_RS02765	COG1841	ribosomal large subunit assembly
SPSE_RS02775	COG0201	protein transport
SPSE_RS02790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SPSE_RS02800	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SPSE_RS02805	COG0202	RNA polymerase activity
SPSE_RS02810	COG0203	ribosomal protein L17
SPSE_RS02815	COG1122	ATPase activity
SPSE_RS02820	COG1122	ATPase activity
SPSE_RS02830	COG0101	tRNA pseudouridine synthase activity
SPSE_RS02835	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPSE_RS02840	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SPSE_RS02850	COG3344	reverse transcriptase
SPSE_RS02865	COG1349	DNA-binding transcription factor activity
SPSE_RS02880	COG3684	Belongs to the aldolase LacD family
SPSE_RS02890	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPSE_RS02890	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPSE_RS02900	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
SPSE_RS02905	COG1518	maintenance of DNA repeat elements
SPSE_RS02925	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SPSE_RS02940	COG1302	Protein conserved in bacteria
SPSE_RS02945	COG2814	Major facilitator Superfamily
SPSE_RS02950	COG4264	IucA IucC family
SPSE_RS02955	COG2814	Major facilitator Superfamily
SPSE_RS02960	COG4264	IucA IucC family
SPSE_RS02965	COG3457	Alanine racemase
SPSE_RS02970	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
SPSE_RS02975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPSE_RS02980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPSE_RS02985	COG3314	Sporulation integral membrane protein YlbJ
SPSE_RS02995	COG1988	membrane-bound metal-dependent
SPSE_RS03000	COG4284	Utp--glucose-1-phosphate uridylyltransferase
SPSE_RS03005	COG1272	protein, Hemolysin III
SPSE_RS03025	COG2814	Major facilitator Superfamily
SPSE_RS03030	COG0489	protein tyrosine kinase activity
SPSE_RS03095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPSE_RS03100	COG0246	Mannitol dehydrogenase
SPSE_RS03110	COG3711	transcriptional antiterminator
SPSE_RS03140	COG1119	ATPase activity
SPSE_RS03145	COG0561	phosphatase activity
SPSE_RS03155	COG2186	Transcriptional regulator
SPSE_RS03160	COG1482	cell wall glycoprotein biosynthetic process
SPSE_RS03180	COG1757	Na H antiporter
SPSE_RS03190	COG0813	purine-nucleoside phosphorylase activity
SPSE_RS03225	COG5146	pantothenate kinase activity
SPSE_RS03240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPSE_RS03250	COG0504	CTP synthase activity
SPSE_RS03255	COG2271	Major facilitator Superfamily
SPSE_RS03260	COG4821	SIS domain
SPSE_RS03265	COG0191	fructose-bisphosphate aldolase activity
SPSE_RS03270	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPSE_RS03275	COG1733	regulation of RNA biosynthetic process
SPSE_RS03285	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SPSE_RS03290	COG0254	rRNA binding
SPSE_RS03300	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SPSE_RS03305	COG2890	protein-(glutamine-N5) methyltransferase activity
SPSE_RS03310	COG0009	L-threonylcarbamoyladenylate synthase
SPSE_RS03315	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPSE_RS03320	COG4475	Protein of unknown function (DUF436)
SPSE_RS03325	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SPSE_RS03330	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SPSE_RS03335	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SPSE_RS03345	COG0356	it plays a direct role in the translocation of protons across the membrane
SPSE_RS03350	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPSE_RS03360	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPSE_RS03370	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SPSE_RS03400	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SPSE_RS03415	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SPSE_RS03425	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SPSE_RS03430	COG0352	thiamine-phosphate diphosphorylase activity
SPSE_RS03435	COG0706	membrane insertase activity
SPSE_RS03440	COG1418	mRNA catabolic process
SPSE_RS03445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPSE_RS03450	COG1937	Protein conserved in bacteria
SPSE_RS03465	COG2217	Heavy metal translocating P-type atpase
SPSE_RS03480	COG0772	Belongs to the SEDS family
SPSE_RS03485	COG1181	Belongs to the D-alanine--D-alanine ligase family
SPSE_RS03490	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPSE_RS03495	COG0513	Belongs to the DEAD box helicase family
SPSE_RS03510	COG3402	PFAM membrane-flanked domain
SPSE_RS03515	COG0736	holo-[acyl-carrier-protein] synthase activity
SPSE_RS03520	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SPSE_RS03530	COG2337	Toxic component of a toxin-antitoxin (TA) module
SPSE_RS03535	COG2208	phosphoserine phosphatase activity
SPSE_RS03540	COG1366	Belongs to the anti-sigma-factor antagonist family
SPSE_RS03550	COG1191	sigma factor activity
SPSE_RS03555	COG2183	response to ionizing radiation
SPSE_RS03560	COG3091	SprT-like family
SPSE_RS03605	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SPSE_RS03615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SPSE_RS03620	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SPSE_RS03630	COG0028	Belongs to the TPP enzyme family
SPSE_RS03635	COG0129	dihydroxy-acid dehydratase activity
SPSE_RS03640	COG0802	atpase or kinase
SPSE_RS03645	COG1214	PFAM Peptidase M22, glycoprotease
SPSE_RS03650	COG0456	acetyltransferase
SPSE_RS03655	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SPSE_RS03660	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SPSE_RS03665	COG0488	(ABC) transporter
SPSE_RS03670	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SPSE_RS03675	COG2814	Major facilitator Superfamily
SPSE_RS03680	COG1846	Transcriptional regulator
SPSE_RS03690	COG2124	cytochrome p450
SPSE_RS03695	COG1609	Transcriptional regulator
SPSE_RS03700	COG1621	beta-fructofuranosidase activity
SPSE_RS03705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SPSE_RS03725	COG4512	PFAM Accessory gene regulator B
SPSE_RS03745	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SPSE_RS03760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPSE_RS03765	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SPSE_RS03790	COG1131	(ABC) transporter
SPSE_RS03805	COG1070	Carbohydrate kinase
SPSE_RS03810	COG2610	gluconate transmembrane transporter activity
SPSE_RS03830	COG3344	reverse transcriptase
SPSE_RS03845	COG2706	6-phosphogluconolactonase activity
SPSE_RS03850	COG1012	belongs to the aldehyde dehydrogenase family
SPSE_RS03860	COG1227	inorganic diphosphatase activity
SPSE_RS03865	COG1335	isochorismatase
SPSE_RS03875	COG0077	Prephenate dehydratase
SPSE_RS03885	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPSE_RS03895	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
SPSE_RS03905	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPSE_RS03910	COG4496	protein, YerC YecD
SPSE_RS03920	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
SPSE_RS03925	COG0210	DNA helicase
SPSE_RS03930	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SPSE_RS03935	COG4851	CamS sex pheromone cAM373 precursor
SPSE_RS03940	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPSE_RS03945	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SPSE_RS03955	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SPSE_RS03960	COG1597	lipid kinase activity
SPSE_RS03985	COG0488	(ABC) transporter
SPSE_RS03990	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SPSE_RS04005	COG2211	Major facilitator Superfamily
SPSE_RS04015	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SPSE_RS04025	COG1528	Iron-storage protein
SPSE_RS04040	COG4129	membrane
SPSE_RS04045	COG0024	Methionine aminopeptidase
SPSE_RS04070	COG0288	reversible hydration of carbon dioxide
SPSE_RS04075	COG1295	ribonuclease BN
SPSE_RS04090	COG4840	Belongs to the UPF0435 family
SPSE_RS04095	COG2309	aminopeptidase activity
SPSE_RS04100	COG1607	acyl-coa hydrolase
SPSE_RS04105	COG0535	radical SAM domain protein
SPSE_RS04110	COG0693	protein deglycase activity
SPSE_RS04115	COG0028	Belongs to the TPP enzyme family
SPSE_RS04120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPSE_RS04125	COG2137	regulation of response to DNA damage stimulus
SPSE_RS04135	COG1388	LysM domain
SPSE_RS04135	COG1134	teichoic acid transport
SPSE_RS04145	COG1988	membrane-bound metal-dependent
SPSE_RS04150	COG1194	a g-specific adenine glycosylase
SPSE_RS04155	COG3557	Belongs to the UPF0374 family
SPSE_RS04165	COG0069	glutamate synthase activity
SPSE_RS04170	COG4129	membrane
SPSE_RS04175	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SPSE_RS04180	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SPSE_RS04190	COG0735	belongs to the Fur family
SPSE_RS04425	COG0765	amino acid transport
SPSE_RS04430	COG1126	abc transporter atp-binding protein
SPSE_RS04435	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SPSE_RS04445	COG0363	glucosamine-6-phosphate deaminase activity
SPSE_RS04455	COG0114	fumarate hydratase activity
SPSE_RS04460	COG0248	Ppx GppA phosphatase
SPSE_RS04465	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SPSE_RS04470	COG0564	pseudouridine synthase activity
SPSE_RS04475	COG2203	Gaf domain
SPSE_RS04475	COG4585	Histidine kinase
SPSE_RS04480	COG2197	response regulator
SPSE_RS04490	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPSE_RS04500	COG4399	Belongs to the UPF0754 family
SPSE_RS04505	COG3679	Belongs to the UPF0342 family
SPSE_RS04510	COG0420	3'-5' exonuclease activity
SPSE_RS04520	COG3481	metal-dependent phosphohydrolase, HD sub domain
SPSE_RS04525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SPSE_RS04535	COG1846	Transcriptional regulator
SPSE_RS04545	COG0537	adenosine 5'-monophosphoramidase activity
SPSE_RS04550	COG1131	(ABC) transporter
SPSE_RS04555	COG4473	ABC transporter
SPSE_RS04560	COG3344	reverse transcriptase
SPSE_RS04570	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SPSE_RS04580	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SPSE_RS04585	COG3545	Serine hydrolase
SPSE_RS04670	COG3037	sugar-specific permease SgaT UlaA
SPSE_RS04690	COG3623	hexulose-6-phosphate isomerase
SPSE_RS04695	COG0235	Class ii aldolase
SPSE_RS04715	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SPSE_RS04720	COG0494	nUDIX hydrolase
SPSE_RS04725	COG1506	peptidase
SPSE_RS04730	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SPSE_RS04735	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SPSE_RS04745	COG0656	L-ascorbic acid biosynthetic process
SPSE_RS04750	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPSE_RS04755	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPSE_RS04765	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SPSE_RS04790	COG3266	domain, Protein
SPSE_RS04790	COG4193	domain, Protein
SPSE_RS04790	COG5632	N-Acetylmuramoyl-L-alanine amidase
SPSE_RS04800	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SPSE_RS04800	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SPSE_RS04805	COG0307	riboflavin synthase, alpha
SPSE_RS04810	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPSE_RS04810	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPSE_RS04815	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SPSE_RS04830	COG2267	carboxylic ester hydrolase activity
SPSE_RS04835	COG0039	L-malate dehydrogenase activity
SPSE_RS04845	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SPSE_RS04850	COG1242	4 iron, 4 sulfur cluster binding
SPSE_RS04855	COG2814	Major facilitator Superfamily
SPSE_RS04860	COG0495	leucyl-tRNA aminoacylation
SPSE_RS04865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPSE_RS04870	COG2081	HI0933 family
SPSE_RS04875	COG2244	polysaccharide biosynthetic process
SPSE_RS04880	COG1187	pseudouridine synthase activity
SPSE_RS04890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPSE_RS04895	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPSE_RS04900	COG0510	thiamine kinase activity
SPSE_RS04905	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SPSE_RS04910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SPSE_RS04920	COG1363	Peptidase, m42
SPSE_RS04925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPSE_RS04930	COG4848	Belongs to the UPF0354 family
SPSE_RS04935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPSE_RS04940	COG1674	ftsk spoiiie
SPSE_RS04945	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SPSE_RS04950	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
SPSE_RS04960	COG1605	Chorismate mutase
SPSE_RS04960	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SPSE_RS04965	COG1609	Transcriptional regulator
SPSE_RS04975	COG0454	-acetyltransferase
SPSE_RS04980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SPSE_RS04985	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SPSE_RS04990	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SPSE_RS05000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPSE_RS05005	COG0204	Acyl-transferase
SPSE_RS05015	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SPSE_RS05020	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SPSE_RS05025	COG1764	response to oxidative stress
SPSE_RS05070	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SPSE_RS05075	COG1956	GAF domain-containing protein
SPSE_RS05080	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
SPSE_RS05090	COG1104	cysteine desulfurase activity
SPSE_RS05095	COG0301	tRNA thio-modification
SPSE_RS05105	COG0616	signal peptide processing
SPSE_RS05110	COG1714	RDD family
SPSE_RS05115	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SPSE_RS05120	COG0827	DNA restriction-modification system
SPSE_RS05125	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SPSE_RS05130	COG0589	response to stress
SPSE_RS05135	COG0686	Belongs to the AlaDH PNT family
SPSE_RS05145	COG0006	proline dipeptidase activity
SPSE_RS05150	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SPSE_RS05160	COG4109	DRTGG domain
SPSE_RS05165	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPSE_RS05170	COG0587	DNA-directed DNA polymerase activity
SPSE_RS05175	COG0281	malic enzyme
SPSE_RS05180	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SPSE_RS05185	COG0825	malonyl-CoA metabolic process
SPSE_RS05190	COG0205	6-phosphofructokinase activity
SPSE_RS05195	COG0469	pyruvate kinase activity
SPSE_RS05200	COG0372	Belongs to the citrate synthase family
SPSE_RS05205	COG0538	isocitrate dehydrogenase activity
SPSE_RS05215	COG0745	RESPONSE REGULATOR receiver
SPSE_RS05220	COG5002	protein histidine kinase activity
SPSE_RS05225	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPSE_RS05225	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPSE_RS05235	COG0237	dephospho-CoA kinase activity
SPSE_RS05250	COG3611	Membrane attachment protein
SPSE_RS05255	COG1484	DNA-dependent DNA replication
SPSE_RS05265	COG0833	amino acid
SPSE_RS05270	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SPSE_RS05275	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SPSE_RS05280	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SPSE_RS05295	COG0544	peptidyl-prolyl cis-trans isomerase activity
SPSE_RS05305	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SPSE_RS05310	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SPSE_RS05320	COG0181	hydroxymethylbilane synthase activity
SPSE_RS05335	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SPSE_RS05350	COG2818	Glycosylase
SPSE_RS05355	COG0525	valine-tRNA ligase activity
SPSE_RS05360	COG0285	dihydrofolate synthase activity
SPSE_RS05365	COG2003	Belongs to the UPF0758 family
SPSE_RS05380	COG2868	ribosomal protein
SPSE_RS05390	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SPSE_RS05400	COG0632	four-way junction helicase activity
SPSE_RS05405	COG2255	four-way junction helicase activity
SPSE_RS05410	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SPSE_RS05420	COG1862	Preprotein translocase
SPSE_RS05425	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SPSE_RS05425	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SPSE_RS05430	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPSE_RS05430	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPSE_RS05435	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPSE_RS05445	COG1490	D-aminoacyl-tRNA deacylase activity
SPSE_RS05450	COG0860	N-Acetylmuramoyl-L-alanine amidase
SPSE_RS05460	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SPSE_RS05465	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SPSE_RS05470	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPSE_RS05475	COG1959	2 iron, 2 sulfur cluster binding
SPSE_RS05490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPSE_RS05495	COG1104	cysteine desulfurase activity
SPSE_RS05500	COG0482	sulfurtransferase activity
SPSE_RS05510	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPSE_RS05515	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SPSE_RS05520	COG4472	Bacterial protein of unknown function (DUF965)
SPSE_RS05525	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SPSE_RS05530	COG3906	Belongs to the UPF0473 family
SPSE_RS05535	COG4122	O-methyltransferase activity
SPSE_RS05540	COG0826	peptidase U32
SPSE_RS05545	COG0826	peptidase U32
SPSE_RS05550	COG0572	uridine kinase
SPSE_RS05560	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SPSE_RS05565	COG1984	allophanate hydrolase subunit 2
SPSE_RS05570	COG0511	ligase activity, forming carbon-carbon bonds
SPSE_RS05575	COG0439	Biotin carboxylase
SPSE_RS05580	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SPSE_RS05585	COG1914	H( )-stimulated, divalent metal cation uptake system
SPSE_RS05590	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPSE_RS05595	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SPSE_RS05600	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPSE_RS05605	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SPSE_RS05610	COG1534	Rna-binding protein
SPSE_RS05620	COG1713	HD superfamily hydrolase involved in NAD metabolism
SPSE_RS05625	COG0799	negative regulation of ribosome biogenesis
SPSE_RS05630	COG2226	methyltransferase
SPSE_RS05635	COG1555	photosystem II stabilization
SPSE_RS05635	COG1596	polysaccharide export
SPSE_RS05640	COG2131	deaminase
SPSE_RS05645	COG2333	competence protein COMEC
SPSE_RS05645	COG0658	competence protein
SPSE_RS05650	COG1466	dna polymerase III delta subunit
SPSE_RS05655	COG0268	Binds directly to 16S ribosomal RNA
SPSE_RS05665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPSE_RS05680	COG0443	Heat shock 70 kDa protein
SPSE_RS05685	COG0484	heat shock protein binding
SPSE_RS05690	COG2264	protein methyltransferase activity
SPSE_RS05695	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPSE_RS05700	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SPSE_RS05715	COG1030	water channel activity
SPSE_RS05720	COG4864	UPF0365 protein
SPSE_RS05730	COG1702	phosphate starvation-inducible protein PhoH
SPSE_RS05740	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPSE_RS05750	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SPSE_RS05755	COG1381	Involved in DNA repair and RecF pathway recombination
SPSE_RS05760	COG0423	glycine-tRNA ligase activity
SPSE_RS05765	COG0517	IMP dehydrogenase activity
SPSE_RS05770	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SPSE_RS05775	COG0358	DNA primase activity
SPSE_RS05780	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPSE_RS05785	COG2384	SAM-dependent methyltransferase
SPSE_RS05790	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SPSE_RS05795	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SPSE_RS05800	COG0513	Belongs to the DEAD box helicase family
SPSE_RS05805	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SPSE_RS05810	COG1121	(ABC) transporter
SPSE_RS05815	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPSE_RS05820	COG0735	belongs to the Fur family
SPSE_RS05825	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SPSE_RS05835	COG0768	penicillin binding
SPSE_RS05840	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPSE_RS05845	COG0573	inorganic phosphate transmembrane transporter activity
SPSE_RS05850	COG0581	inorganic phosphate transmembrane transporter activity
SPSE_RS05855	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPSE_RS05860	COG0704	Plays a role in the regulation of phosphate uptake
SPSE_RS05870	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SPSE_RS05875	COG0457	Tetratricopeptide repeat
SPSE_RS05875	COG0705	Rhomboid family
SPSE_RS05880	COG4483	Protein conserved in bacteria
SPSE_RS05885	COG1940	carbohydrate kinase activity
SPSE_RS05890	COG0011	TIGRFAM Protein of
SPSE_RS05895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SPSE_RS05900	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPSE_RS05930	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SPSE_RS05935	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SPSE_RS05945	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SPSE_RS05950	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPSE_RS05955	COG0095	Lipoate-protein ligase
SPSE_RS05970	COG0006	proline dipeptidase activity
SPSE_RS05975	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SPSE_RS05980	COG0511	ligase activity, forming carbon-carbon bonds
SPSE_RS05985	COG0439	Biotin carboxylase
SPSE_RS05990	COG1302	Protein conserved in bacteria
SPSE_RS06000	COG1570	exodeoxyribonuclease VII activity
SPSE_RS06005	COG1722	exodeoxyribonuclease VII activity
SPSE_RS06010	COG0142	geranyltranstransferase activity
SPSE_RS06015	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SPSE_RS06020	COG1438	arginine binding
SPSE_RS06025	COG0497	DNA recombination
SPSE_RS06030	COG0280	phosphate acetyltransferase
SPSE_RS06035	COG3426	butyrate kinase activity
SPSE_RS06040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPSE_RS06045	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPSE_RS06050	COG0022	dehydrogenase e1 component
SPSE_RS06055	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPSE_RS06065	COG4129	membrane
SPSE_RS06070	COG2195	Cleaves the N-terminal amino acid of tripeptides
SPSE_RS06100	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SPSE_RS06105	COG1234	tRNA 3'-trailer cleavage
SPSE_RS06110	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPSE_RS06120	COG0667	Aldo Keto reductase
SPSE_RS06125	COG0494	nUDIX hydrolase
SPSE_RS06130	COG0735	belongs to the Fur family
SPSE_RS06145	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SPSE_RS06150	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SPSE_RS06155	COG1187	pseudouridine synthase activity
SPSE_RS06160	COG0745	RESPONSE REGULATOR receiver
SPSE_RS06175	COG1141	Ferredoxin
SPSE_RS06185	COG0514	ATP-dependent DNA helicase (RecQ)
SPSE_RS06195	COG0492	ferredoxin-NADP+ reductase activity
SPSE_RS06200	COG0252	asparaginase activity
SPSE_RS06210	COG0539	negative regulation of cytoplasmic translation
SPSE_RS06215	COG1160	GTP binding
SPSE_RS06220	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SPSE_RS06240	COG0142	geranyltranstransferase activity
SPSE_RS06245	COG0105	UTP biosynthetic process
SPSE_RS06255	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SPSE_RS06265	COG0457	Tetratricopeptide repeat
SPSE_RS06270	COG5582	Belongs to the UPF0302 family
SPSE_RS06275	COG4347	Protein of unknown function (DUF1405)
SPSE_RS06285	COG1694	Mazg nucleotide pyrophosphohydrolase
SPSE_RS06290	COG0438	transferase activity, transferring glycosyl groups
SPSE_RS06295	COG0617	tRNA 3'-terminal CCA addition
SPSE_RS06310	COG0017	Asparaginyl-tRNA synthetase
SPSE_RS06315	COG3935	DnaD domain protein
SPSE_RS06320	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPSE_RS06330	COG4499	WXG100 protein secretion system (Wss), protein YukC
SPSE_RS06330	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPSE_RS06345	COG4474	Belongs to the UPF0398 family
SPSE_RS06350	COG3599	regulation of cell shape
SPSE_RS06355	COG0116	Belongs to the methyltransferase superfamily
SPSE_RS06360	COG2962	Rard protein
SPSE_RS06365	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SPSE_RS06370	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPSE_RS06380	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SPSE_RS06390	COG1413	lyase activity
SPSE_RS06425	COG2190	(PTS) system
SPSE_RS06435	COG0793	Belongs to the peptidase S41A family
SPSE_RS06445	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SPSE_RS06450	COG0671	phosphoesterase, PA-phosphatase related
SPSE_RS06460	COG5002	protein histidine kinase activity
SPSE_RS06465	COG0567	Dehydrogenase, E1 component
SPSE_RS06490	COG0714	Associated with various cellular activities
SPSE_RS06495	COG4548	von Willebrand factor, type A
SPSE_RS06500	COG1114	Component of the transport system for branched-chain amino acids
SPSE_RS06505	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SPSE_RS06510	COG3853	Toxic anion resistance protein (TelA)
SPSE_RS06530	COG1278	Cold shock
SPSE_RS06550	COG1473	amidohydrolase
SPSE_RS06555	COG2171	N-acyltransferase activity
SPSE_RS06560	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SPSE_RS06565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPSE_RS06570	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SPSE_RS06575	COG0488	(ABC) transporter
SPSE_RS06580	COG2996	Protein conserved in bacteria
SPSE_RS06610	COG1363	Peptidase, m42
SPSE_RS06615	COG0287	Prephenate dehydrogenase
SPSE_RS06620	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SPSE_RS06630	COG1942	4-Oxalocrotonate Tautomerase
SPSE_RS06650	COG0628	permease
SPSE_RS06660	COG3711	transcriptional antiterminator
SPSE_RS06670	COG1115	amino acid carrier protein
SPSE_RS06675	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPSE_RS06685	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SPSE_RS06690	COG4841	protein insertion into membrane
SPSE_RS06695	COG0824	Thioesterase
SPSE_RS06705	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SPSE_RS06710	COG1970	mechanosensitive ion channel activity
SPSE_RS06715	COG0419	ATPase involved in DNA repair
SPSE_RS06720	COG0420	3'-5' exonuclease activity
SPSE_RS06725	COG3344	reverse transcriptase
SPSE_RS06730	COG4846	Membrane protein involved in cytochrome C biogenesis
SPSE_RS06735	COG3763	UPF0154 protein
SPSE_RS06745	COG4224	UPF0291 protein
SPSE_RS06755	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SPSE_RS06765	COG0516	GMP reductase activity
SPSE_RS06770	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SPSE_RS06780	COG0833	amino acid
SPSE_RS06795	COG0083	homoserine kinase activity
SPSE_RS06800	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SPSE_RS06805	COG0460	homoserine dehydrogenase
SPSE_RS06810	COG0527	aspartate kinase activity
SPSE_RS06830	COG1525	nuclease
SPSE_RS06860	COG0584	glycerophosphoryl diester phosphodiesterase
SPSE_RS06885	COG4974	Belongs to the 'phage' integrase family
SPSE_RS06895	COG0789	Transcriptional regulator
SPSE_RS06900	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SPSE_RS06905	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPSE_RS06910	COG0386	Belongs to the glutathione peroxidase family
SPSE_RS06915	COG2267	carboxylic ester hydrolase activity
SPSE_RS06920	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SPSE_RS06925	COG1923	regulation of RNA biosynthetic process
SPSE_RS06930	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SPSE_RS06940	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPSE_RS06945	COG1619	proteins homologs of microcin C7 resistance protein MccF
SPSE_RS06950	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
SPSE_RS06955	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SPSE_RS06975	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SPSE_RS06985	COG1013	pyruvate-flavodoxin oxidoreductase activity
SPSE_RS06990	COG0674	pyruvate-flavodoxin oxidoreductase activity
SPSE_RS06990	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SPSE_RS06995	COG1692	metallophosphoesterase
SPSE_RS07015	COG1418	mRNA catabolic process
SPSE_RS07020	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SPSE_RS07025	COG1058	Belongs to the CinA family
SPSE_RS07025	COG1546	Belongs to the CinA family
SPSE_RS07045	COG0300	oxidoreductase activity
SPSE_RS07050	COG0612	Peptidase, M16
SPSE_RS07055	COG0612	Peptidase, M16
SPSE_RS07060	COG2188	Transcriptional regulator
SPSE_RS07075	COG1185	polyribonucleotide nucleotidyltransferase activity
SPSE_RS07085	COG0196	riboflavin kinase activity
SPSE_RS07090	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SPSE_RS07095	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SPSE_RS07105	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SPSE_RS07110	COG1358	cellular component organization or biogenesis
SPSE_RS07115	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SPSE_RS07120	COG0195	Participates in both transcription termination and antitermination
SPSE_RS07125	COG0779	Required for maturation of 30S ribosomal subunits
SPSE_RS07135	COG0442	prolyl-tRNA aminoacylation
SPSE_RS07145	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SPSE_RS07150	COG4589	Belongs to the CDS family
SPSE_RS07160	COG0233	cytoplasmic translational termination
SPSE_RS07165	COG0528	UMP kinase activity
SPSE_RS07170	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SPSE_RS07175	COG0052	Belongs to the universal ribosomal protein uS2 family
SPSE_RS07180	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SPSE_RS07185	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SPSE_RS07190	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SPSE_RS07195	COG4974	Belongs to the 'phage' integrase family
SPSE_RS07200	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SPSE_RS07205	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPSE_RS07210	COG0758	DNA mediated transformation
SPSE_RS07220	COG0045	succinate-CoA ligase (ADP-forming) activity
SPSE_RS07230	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SPSE_RS07245	COG4485	Bacterial membrane protein, YfhO
SPSE_RS07285	COG0336	Belongs to the RNA methyltransferase TrmD family
SPSE_RS07290	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SPSE_RS07295	COG0228	four-way junction DNA binding
SPSE_RS07305	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SPSE_RS07355	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPSE_RS07360	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
SPSE_RS07365	COG0552	protein localization to endoplasmic reticulum
SPSE_RS07370	COG1196	nuclear chromosome segregation
SPSE_RS07375	COG0571	ribonuclease III activity
SPSE_RS07380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPSE_RS07395	COG0416	fatty acid biosynthetic process
SPSE_RS07400	COG1349	DNA-binding transcription factor activity
SPSE_RS07410	COG1760	l-serine dehydratase
SPSE_RS07415	COG1760	l-serine dehydratase
SPSE_RS07425	COG1302	Protein conserved in bacteria
SPSE_RS07440	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SPSE_RS07445	COG1162	GTPase activity
SPSE_RS07450	COG2124	cytochrome p450
SPSE_RS07465	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SPSE_RS07470	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPSE_RS07470	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPSE_RS07475	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SPSE_RS07480	COG0242	peptide deformylase activity
SPSE_RS07485	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPSE_RS07490	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPSE_RS07495	COG1758	RNA polymerase activity
SPSE_RS07515	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SPSE_RS07520	COG0284	orotidine-5'-phosphate decarboxylase activity
SPSE_RS07525	COG0167	dihydroorotate dehydrogenase activity
SPSE_RS07535	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SPSE_RS07540	COG0505	Belongs to the CarA family
SPSE_RS07560	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SPSE_RS07565	COG0564	pseudouridine synthase activity
SPSE_RS07570	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SPSE_RS07575	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SPSE_RS07580	COG3599	regulation of cell shape
SPSE_RS07590	COG0673	inositol 2-dehydrogenase activity
SPSE_RS07595	COG4409	exo-alpha-(2->6)-sialidase activity
SPSE_RS07605	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPSE_RS07610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPSE_RS07620	COG4975	Glucose uptake
SPSE_RS07625	COG1869	D-ribose catabolic process
SPSE_RS07630	COG0762	integral membrane protein
SPSE_RS07635	COG1799	cell septum assembly
SPSE_RS07640	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPSE_RS07650	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SPSE_RS07655	COG0849	cell division
SPSE_RS07665	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SPSE_RS07675	COG0768	penicillin binding
SPSE_RS07680	COG4839	cell division protein FtsL
SPSE_RS07685	COG0275	rRNA processing
SPSE_RS07690	COG2001	Belongs to the MraZ family
SPSE_RS07695	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
SPSE_RS07700	COG0454	-acetyltransferase
SPSE_RS07705	COG1011	Hydrolase
SPSE_RS07715	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPSE_RS07760	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SPSE_RS07765	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SPSE_RS07770	COG1053	succinate dehydrogenase
SPSE_RS07775	COG2009	succinate dehydrogenase
SPSE_RS07780	COG0322	excinuclease ABC activity
SPSE_RS07785	COG3118	belongs to the thioredoxin family
SPSE_RS07790	COG1193	negative regulation of DNA recombination
SPSE_RS07795	COG1796	DNA polymerase
SPSE_RS07795	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SPSE_RS07810	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SPSE_RS07825	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SPSE_RS07830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPSE_RS07835	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SPSE_RS07855	COG0742	ribosomal rna small subunit methyltransferase
SPSE_RS07865	COG4471	UPF0298 protein
SPSE_RS07870	COG0584	glycerophosphoryl diester phosphodiesterase
SPSE_RS07875	COG3679	Belongs to the UPF0342 family
SPSE_RS07890	COG0109	protoheme IX farnesyltransferase activity
SPSE_RS07910	COG3344	reverse transcriptase
SPSE_RS07915	COG0772	Belongs to the SEDS family
SPSE_RS07920	COG4838	Belongs to the UPF0358 family
SPSE_RS07925	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SPSE_RS07930	COG4896	Protein conserved in bacteria
SPSE_RS07935	COG1902	pentaerythritol trinitrate reductase activity
SPSE_RS07940	COG1217	gtp-binding protein TYPA
SPSE_RS07950	COG0483	inositol monophosphate 1-phosphatase activity
SPSE_RS07955	COG4493	Belongs to the UPF0637 family
SPSE_RS07970	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SPSE_RS07975	COG1177	transmembrane transport
SPSE_RS07985	COG3842	ATPase activity
SPSE_RS07995	COG4476	Belongs to the UPF0223 family
SPSE_RS08035	COG5503	Protein of unknown function (DUF1447)
SPSE_RS08040	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SPSE_RS08050	COG0569	domain protein
SPSE_RS08055	COG1294	oxidase, subunit
SPSE_RS08060	COG1271	oxidase subunit
SPSE_RS08065	COG1393	Belongs to the ArsC family
SPSE_RS08070	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SPSE_RS08075	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPSE_RS08085	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPSE_RS08100	COG4172	Belongs to the ABC transporter superfamily
SPSE_RS08110	COG0151	Belongs to the GarS family
SPSE_RS08115	COG0138	bifunctional purine biosynthesis protein purh
SPSE_RS08125	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SPSE_RS08130	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SPSE_RS08140	COG0047	phosphoribosylformylglycinamidine synthase activity
SPSE_RS08145	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPSE_RS08150	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SPSE_RS08155	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SPSE_RS08160	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPSE_RS08165	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SPSE_RS08170	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SPSE_RS08170	COG1017	nitric oxide dioxygenase activity
SPSE_RS08180	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SPSE_RS08190	COG1845	cytochrome c oxidase, subunit III
SPSE_RS08195	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
SPSE_RS08205	COG3973	AAA domain
SPSE_RS08245	COG3212	peptidase
SPSE_RS08260	COG1134	teichoic acid transport
SPSE_RS08270	COG1682	transport, permease protein
SPSE_RS08280	COG1215	transferase activity, transferring glycosyl groups
SPSE_RS08290	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
SPSE_RS08295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPSE_RS08300	COG1316	TRANSCRIPTIONal
SPSE_RS08325	COG3594	Acyltransferase
SPSE_RS08330	COG0436	Aminotransferase
SPSE_RS08335	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SPSE_RS08345	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SPSE_RS08350	COG1169	isochorismate synthase
SPSE_RS08355	COG1575	Belongs to the MenA family. Type 1 subfamily
SPSE_RS08360	COG0390	transport system, permease component
SPSE_RS08365	COG4619	ABC transporter
SPSE_RS08375	COG3682	Transcriptional regulator
SPSE_RS08405	COG4974	Belongs to the 'phage' integrase family
SPSE_RS08425	COG4873	Protein conserved in bacteria
SPSE_RS08480	COG2378	regulation of single-species biofilm formation
SPSE_RS08490	COG0456	acetyltransferase
SPSE_RS08500	COG2226	methyltransferase
SPSE_RS08540	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
SPSE_RS08550	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
SPSE_RS08550	COG4932	domain protein
SPSE_RS08550	COG3266	domain, Protein
SPSE_RS08555	COG0737	Belongs to the 5'-nucleotidase family
SPSE_RS08565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SPSE_RS08570	COG1696	Membrane protein involved in D-alanine export
SPSE_RS08580	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SPSE_RS08585	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPSE_RS08590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPSE_RS08595	COG0861	Integral membrane protein TerC family
SPSE_RS08600	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SPSE_RS08610	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SPSE_RS08620	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SPSE_RS08625	COG2814	Major facilitator Superfamily
SPSE_RS08635	COG3715	PTS system
SPSE_RS08640	COG3716	PTS system mannose fructose sorbose family IID component
SPSE_RS08645	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SPSE_RS08650	COG2382	esterase
SPSE_RS08655	COG1115	amino acid carrier protein
SPSE_RS08660	COG0628	permease
SPSE_RS08665	COG4409	exo-alpha-(2->6)-sialidase activity
SPSE_RS08670	COG2211	Major facilitator Superfamily
SPSE_RS08675	COG0673	inositol 2-dehydrogenase activity
SPSE_RS08685	COG0475	glutathione-regulated potassium exporter activity
SPSE_RS08685	COG0569	domain protein
SPSE_RS08690	COG2239	Acts as a magnesium transporter
SPSE_RS08695	COG0564	pseudouridine synthase activity
SPSE_RS08705	COG2357	RelA SpoT domain protein
SPSE_RS08720	COG2346	COG2346, Truncated hemoglobins
SPSE_RS08725	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SPSE_RS08735	COG1164	Oligoendopeptidase f
SPSE_RS08750	COG3591	Belongs to the peptidase S1B family
SPSE_RS08760	COG1393	Belongs to the ArsC family
SPSE_RS08765	COG0180	Tryptophanyl-tRNA synthetase
SPSE_RS08770	COG4166	transmembrane transport
SPSE_RS08775	COG4608	Belongs to the ABC transporter superfamily
SPSE_RS08780	COG0444	Belongs to the ABC transporter superfamily
SPSE_RS08785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPSE_RS08790	COG0601	transmembrane transport
SPSE_RS08815	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SPSE_RS08835	COG0561	phosphatase activity
SPSE_RS08840	COG0446	pyridine nucleotide-disulphide oxidoreductase
SPSE_RS08845	COG3344	reverse transcriptase
SPSE_RS08855	COG0179	Fumarylacetoacetate (FAA) hydrolase
SPSE_RS08860	COG1074	ATP-dependent DNA helicase activity
SPSE_RS08865	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SPSE_RS08880	COG0166	Belongs to the GPI family
SPSE_RS08885	COG0137	argininosuccinate synthase activity
SPSE_RS08895	COG0584	glycerophosphoryl diester phosphodiesterase
SPSE_RS08915	COG1012	belongs to the aldehyde dehydrogenase family
SPSE_RS08920	COG1098	S1 RNA binding domain
SPSE_RS08930	COG1278	Cold shock
SPSE_RS08950	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SPSE_RS08960	COG2111	Na H antiporter
SPSE_RS08960	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SPSE_RS08965	COG2111	Na H antiporter
SPSE_RS08970	COG1006	Multisubunit Na H antiporter MnhC subunit
SPSE_RS08975	COG0651	ATP synthesis coupled electron transport
SPSE_RS08980	COG1863	multisubunit Na H antiporter MnhE subunit
SPSE_RS08985	COG2212	antiporter activity
SPSE_RS08990	COG1320	monovalent cation:proton antiporter activity
SPSE_RS09000	COG2056	Na+-H+ antiporter family
SPSE_RS09005	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SPSE_RS09010	COG1252	NADH dehydrogenase
SPSE_RS09015	COG0316	Belongs to the HesB IscA family
SPSE_RS09020	COG4844	belongs to the
SPSE_RS09025	COG1252	NADH dehydrogenase
SPSE_RS09030	COG4837	Protein of unknown function (DUF1462)
SPSE_RS09035	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SPSE_RS09040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SPSE_RS09045	COG0647	UMP catabolic process
SPSE_RS09050	COG2445	Protein of unknown function DUF86
SPSE_RS09060	COG4470	Protein conserved in bacteria
SPSE_RS09065	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SPSE_RS09070	COG0737	Belongs to the 5'-nucleotidase family
SPSE_RS09075	COG0730	response to heat
SPSE_RS09080	COG1801	Protein of unknown function DUF72
SPSE_RS09095	COG1253	flavin adenine dinucleotide binding
SPSE_RS09105	COG0719	Fe-S assembly protein
SPSE_RS09110	COG0822	iron-sulfur transferase activity
SPSE_RS09120	COG0719	Fe-S assembly protein
SPSE_RS09125	COG0396	ATPase activity
SPSE_RS09135	COG1464	Belongs to the NlpA lipoprotein family
SPSE_RS09140	COG1464	Belongs to the NlpA lipoprotein family
SPSE_RS09145	COG2011	ABC-type metal ion transport system permease component
SPSE_RS09155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPSE_RS09160	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SPSE_RS09170	COG1393	Belongs to the ArsC family
SPSE_RS09175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPSE_RS09185	COG0710	3-dehydroquinate dehydratase activity
SPSE_RS09195	COG1764	response to oxidative stress
SPSE_RS09210	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPSE_RS09230	COG0346	lactoylglutathione lyase activity
SPSE_RS09255	COG0557	exoribonuclease II activity
SPSE_RS09260	COG1647	Serine aminopeptidase, S33
SPSE_RS09265	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SPSE_RS09275	COG0148	phosphopyruvate hydratase activity
SPSE_RS09280	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SPSE_RS09285	COG0149	triose-phosphate isomerase activity
SPSE_RS09290	COG0126	phosphoglycerate kinase activity
SPSE_RS09310	COG1090	epimerase
SPSE_RS09320	COG0740	serine-type endopeptidase activity
SPSE_RS09330	COG1481	regulation of sporulation
SPSE_RS09335	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SPSE_RS09340	COG1660	Displays ATPase and GTPase activities
SPSE_RS09355	COG0110	maltose O-acetyltransferase activity
SPSE_RS09360	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SPSE_RS09365	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SPSE_RS09395	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SPSE_RS09400	COG0653	protein targeting
SPSE_RS09415	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SPSE_RS09425	COG1739	Uncharacterized protein family UPF0029
SPSE_RS09430	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SPSE_RS09450	COG2195	Cleaves the N-terminal amino acid of tripeptides
SPSE_RS09455	COG1929	Belongs to the glycerate kinase type-1 family
SPSE_RS09460	COG3118	belongs to the thioredoxin family
SPSE_RS09475	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SPSE_RS09485	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPSE_RS09490	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPSE_RS09540	COG3104	oligopeptide transport
SPSE_RS09545	COG3104	oligopeptide transport
SPSE_RS09560	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SPSE_RS09565	COG1174	glycine betaine transport
SPSE_RS09570	COG1125	glycine betaine transport
SPSE_RS09570	COG0517	IMP dehydrogenase activity
SPSE_RS09575	COG0514	ATP-dependent DNA helicase (RecQ)
SPSE_RS09580	COG0488	(ABC) transporter
SPSE_RS09590	COG1368	sulfuric ester hydrolase activity
SPSE_RS09600	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SPSE_RS09620	COG0512	Glutamine amidotransferase of anthranilate synthase
SPSE_RS09630	COG0720	synthase
SPSE_RS09635	COG0602	queuosine metabolic process
SPSE_RS09650	COG0463	Glycosyl transferase, family 2
SPSE_RS09655	COG1253	flavin adenine dinucleotide binding
SPSE_RS09660	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPSE_RS09660	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPSE_RS09660	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPSE_RS09665	COG1105	Belongs to the carbohydrate kinase PfkB family
SPSE_RS09670	COG1349	DNA-binding transcription factor activity
SPSE_RS09690	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SPSE_RS09695	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SPSE_RS09720	COG0039	L-malate dehydrogenase activity
SPSE_RS09740	COG4989	oxidoreductase activity
SPSE_RS09745	COG0523	cobalamin synthesis protein
SPSE_RS09755	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SPSE_RS09760	COG4988	ABC transporter
SPSE_RS09765	COG1968	undecaprenyl-diphosphatase activity
SPSE_RS09775	COG1671	Belongs to the UPF0178 family
SPSE_RS09780	COG1611	Belongs to the LOG family
SPSE_RS09810	COG2839	Protein conserved in bacteria
SPSE_RS09815	COG2814	Major facilitator Superfamily
SPSE_RS09820	COG0583	DNA-binding transcription factor activity
SPSE_RS09835	COG0217	transcriptional regulatory protein
SPSE_RS09840	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SPSE_RS09845	COG2022	thiamine diphosphate biosynthetic process
SPSE_RS09855	COG0352	thiamine-phosphate diphosphorylase activity
SPSE_RS09865	COG3942	CHAP domain
SPSE_RS09865	COG1388	LysM domain
SPSE_RS09870	COG0306	phosphate transporter
SPSE_RS09875	COG1392	Phosphate transport regulator
SPSE_RS09880	COG0577	efflux transmembrane transporter activity
SPSE_RS09885	COG1136	(ABC) transporter
SPSE_RS09895	COG0745	RESPONSE REGULATOR receiver
SPSE_RS09900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SPSE_RS09905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPSE_RS09915	COG3949	Membrane
SPSE_RS09920	COG0477	Major facilitator Superfamily
SPSE_RS09935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPSE_RS09940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPSE_RS09945	COG1120	ATPase activity
SPSE_RS09950	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPSE_RS09955	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SPSE_RS09975	COG1132	(ABC) transporter
SPSE_RS09980	COG1686	Belongs to the peptidase S11 family
SPSE_RS09995	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SPSE_RS10000	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SPSE_RS10005	COG1682	transport, permease protein
SPSE_RS10015	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
SPSE_RS10030	COG1475	DNA binding
SPSE_RS10035	COG0019	diaminopimelate decarboxylase activity
SPSE_RS10045	COG4264	IucA IucC family
SPSE_RS10050	COG4264	IucA IucC family
SPSE_RS10055	COG2814	Major facilitator Superfamily
SPSE_RS10060	COG4264	IucA IucC family
SPSE_RS10065	COG2423	ornithine cyclodeaminase activity
SPSE_RS10075	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SPSE_RS10080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPSE_RS10085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPSE_RS10095	COG1121	(ABC) transporter
SPSE_RS10100	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPSE_RS10105	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPSE_RS10110	COG1320	monovalent cation:proton antiporter activity
SPSE_RS10115	COG2212	antiporter activity
SPSE_RS10120	COG1863	multisubunit Na H antiporter MnhE subunit
SPSE_RS10130	COG1006	Multisubunit Na H antiporter MnhC subunit
SPSE_RS10135	COG2111	Na H antiporter
SPSE_RS10140	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SPSE_RS10140	COG2111	Na H antiporter
SPSE_RS10190	COG0546	phosphoglycolate phosphatase activity
SPSE_RS10195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPSE_RS10200	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SPSE_RS10205	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SPSE_RS10210	COG0805	protein transport
SPSE_RS10215	COG0018	arginyl-trna synthetase
SPSE_RS10230	COG1078	dGTPase activity
SPSE_RS10240	COG4844	belongs to the
SPSE_RS10295	COG0471	metal ion transport
SPSE_RS10320	COG0280	phosphate acetyltransferase
SPSE_RS10325	COG0095	Lipoate-protein ligase
SPSE_RS10350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPSE_RS10355	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SPSE_RS10365	COG2814	Major facilitator Superfamily
SPSE_RS10370	COG1566	PFAM secretion protein HlyD family protein
SPSE_RS10395	COG2363	Small membrane protein
SPSE_RS10425	COG0183	Belongs to the thiolase family
SPSE_RS10430	COG0318	PFAM AMP-dependent synthetase and ligase
SPSE_RS10435	COG0588	phosphoglycerate mutase activity
SPSE_RS10450	COG3344	reverse transcriptase
SPSE_RS10460	COG1131	(ABC) transporter
SPSE_RS10465	COG1994	Peptidase M50
SPSE_RS10470	COG0535	radical SAM domain protein
SPSE_RS10490	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SPSE_RS10495	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SPSE_RS10505	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
SPSE_RS10520	COG2190	(PTS) system
SPSE_RS10520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPSE_RS10520	COG1263	PTS System
SPSE_RS10535	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SPSE_RS10540	COG1469	GTP cyclohydrolase I activity
SPSE_RS10545	COG1136	(ABC) transporter
SPSE_RS10545	COG0577	efflux transmembrane transporter activity
SPSE_RS10560	COG0561	phosphatase activity
SPSE_RS10570	COG1428	Deoxynucleoside kinase
SPSE_RS10575	COG1428	Deoxynucleoside kinase
SPSE_RS10580	COG0546	phosphoglycolate phosphatase activity
SPSE_RS10595	COG1121	(ABC) transporter
SPSE_RS10605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SPSE_RS10615	COG1473	amidohydrolase
SPSE_RS10620	COG3527	Alpha-acetolactate decarboxylase
SPSE_RS10625	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SPSE_RS10630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SPSE_RS10635	COG0049	tRNA binding
SPSE_RS10640	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SPSE_RS10650	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SPSE_RS10655	COG0085	RNA polymerase activity
SPSE_RS10660	COG2813	Specifically methylates the guanine in position
SPSE_RS10670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SPSE_RS10675	COG0081	regulation of translation
SPSE_RS10680	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SPSE_RS10685	COG0250	Participates in transcription elongation, termination and antitermination
SPSE_RS10690	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SPSE_RS10710	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SPSE_RS10715	COG0215	cysteine-tRNA ligase activity
SPSE_RS10720	COG1045	serine acetyltransferase
SPSE_RS10725	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SPSE_RS10735	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SPSE_RS10740	COG4956	integral membrane protein (PIN domain superfamily)
SPSE_RS10745	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SPSE_RS10780	COG0542	response to heat
SPSE_RS10785	COG3869	Catalyzes the specific phosphorylation of arginine residues in
SPSE_RS10790	COG3880	PFAM UvrB UvrC protein
SPSE_RS10800	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SPSE_RS10810	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SPSE_RS10815	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SPSE_RS10820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPSE_RS10825	COG1289	transmembrane transporter activity
SPSE_RS10895	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPSE_RS10900	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SPSE_RS10910	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SPSE_RS10920	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SPSE_RS10925	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPSE_RS10940	COG1098	S1 RNA binding domain
SPSE_RS10950	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPSE_RS10955	COG3956	TIGRFAM MazG family protein
SPSE_RS10960	COG2244	polysaccharide biosynthetic process
SPSE_RS10965	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPSE_RS10970	COG0193	aminoacyl-tRNA hydrolase activity
SPSE_RS10980	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPSE_RS10985	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SPSE_RS10990	COG2088	sporulation resulting in formation of a cellular spore
SPSE_RS10995	COG0251	oxidation-reduction process
SPSE_RS11000	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPSE_RS11005	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SPSE_RS11010	COG4466	Protein conserved in bacteria
SPSE_RS11020	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SPSE_RS11025	COG0084	hydrolase, TatD family'
SPSE_RS11035	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SPSE_RS11040	COG2827	Endonuclease containing a URI domain
SPSE_RS11045	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SPSE_RS11050	COG4467	Involved in initiation control of chromosome replication
SPSE_RS11055	COG1774	PSP1 C-terminal conserved region
SPSE_RS11060	COG0470	DNA polymerase III
SPSE_RS11065	COG3870	Protein conserved in bacteria
SPSE_RS11070	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SPSE_RS11075	COG1982	Orn Lys Arg decarboxylase major
SPSE_RS11100	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SPSE_RS11105	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SPSE_RS11110	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPSE_RS11115	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SPSE_RS11120	COG2188	Transcriptional regulator
SPSE_RS11125	COG0366	Alpha amylase catalytic
SPSE_RS11130	COG1263	PTS System
SPSE_RS11130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPSE_RS11145	COG0493	'glutamate synthase
SPSE_RS11150	COG0067	glutamate synthase
SPSE_RS11150	COG0069	glutamate synthase activity
SPSE_RS11150	COG0070	glutamate synthase
SPSE_RS11155	COG0583	DNA-binding transcription factor activity
SPSE_RS11170	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SPSE_RS11195	COG0626	cystathionine gamma-synthase activity
SPSE_RS11200	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SPSE_RS11205	COG2272	Belongs to the type-B carboxylesterase lipase family
SPSE_RS11210	COG0733	neurotransmitter:sodium symporter activity
SPSE_RS11220	COG0745	RESPONSE REGULATOR receiver
SPSE_RS11225	COG2205	protein histidine kinase activity
SPSE_RS11230	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SPSE_RS11235	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SPSE_RS11250	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SPSE_RS11255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SPSE_RS11255	COG0574	Belongs to the PEP-utilizing enzyme family
SPSE_RS11280	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SPSE_RS11290	COG1486	melibiose metabolic process
SPSE_RS11295	COG1263	PTS System
SPSE_RS11295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPSE_RS11315	COG2210	Belongs to the sulfur carrier protein TusA family
SPSE_RS11320	COG1937	Protein conserved in bacteria
SPSE_RS11325	COG0730	response to heat
SPSE_RS11330	COG2814	Major facilitator Superfamily
SPSE_RS11340	COG3344	reverse transcriptase
SPSE_RS11355	COG3682	Transcriptional regulator
SPSE_RS11380	COG1124	(ABC) transporter
SPSE_RS11385	COG0444	Belongs to the ABC transporter superfamily
SPSE_RS11390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPSE_RS11395	COG0601	transmembrane transport
SPSE_RS11400	COG0747	negative chemotaxis
SPSE_RS11425	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPSE_RS11445	COG1525	nuclease
SPSE_RS11480	COG3328	transposase activity
SPSE_RS11510	COG1674	ftsk spoiiie
SPSE_RS11515	COG2946	Replication initiation factor
SPSE_RS11560	COG0741	lytic transglycosylase activity
SPSE_RS11560	COG0791	NLP P60 protein
SPSE_RS11595	COG0582	viral genome integration into host DNA
SPSE_RS11600	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SPSE_RS11600	COG0519	Catalyzes the synthesis of GMP from XMP
SPSE_RS11605	COG0517	IMP dehydrogenase activity
SPSE_RS11605	COG0516	GMP reductase activity
SPSE_RS11610	COG2233	PERMEase
SPSE_RS11615	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPSE_RS11630	COG5183	chlorophyll binding
SPSE_RS11635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPSE_RS11640	COG1823	symporter activity
SPSE_RS11645	COG1136	(ABC) transporter
SPSE_RS11645	COG0577	efflux transmembrane transporter activity
SPSE_RS11660	COG0778	Nitroreductase
SPSE_RS11665	COG0450	alkyl hydroperoxide reductase
SPSE_RS11680	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SPSE_RS11690	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPSE_RS11695	COG2011	ABC-type metal ion transport system permease component
SPSE_RS11700	COG1464	Belongs to the NlpA lipoprotein family
SPSE_RS11705	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SPSE_RS11710	COG0753	catalase activity
SPSE_RS11720	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SPSE_RS11730	COG0360	Binds together with S18 to 16S ribosomal RNA
SPSE_RS11740	COG1668	transmembrane transport
SPSE_RS11745	COG1131	(ABC) transporter
SPSE_RS11760	COG0012	GTP binding
SPSE_RS11765	COG4481	Protein conserved in bacteria
SPSE_RS11770	COG0668	transmembrane transport
SPSE_RS11775	COG1475	DNA binding
SPSE_RS11780	COG0626	cystathionine gamma-synthase activity
SPSE_RS11785	COG0626	cystathionine gamma-synthase activity
SPSE_RS11790	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SPSE_RS11790	COG0646	methionine synthase
SPSE_RS11795	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SPSE_RS11800	COG0829	nickel cation binding
SPSE_RS11810	COG0830	nickel cation binding
SPSE_RS11815	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SPSE_RS11825	COG2388	GCN5-related N-acetyl-transferase
SPSE_RS11830	COG1846	Transcriptional regulator
SPSE_RS11835	COG0346	lactoylglutathione lyase activity
SPSE_RS11840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SPSE_RS11845	COG0400	carboxylic ester hydrolase activity
SPSE_RS11865	COG0357	Ribosomal RNA small subunit methyltransferase G
SPSE_RS11870	COG0445	tRNA wobble uridine modification
SPSE_RS11875	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SPSE_RS11880	COG0594	ribonuclease P activity
SPSE_RS11985	COG0488	(ABC) transporter