locus-tag	class	description
I6I29_RS00015	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I6I29_RS00020	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6I29_RS00025	COG0110	maltose O-acetyltransferase activity
I6I29_RS00040	COG1660	Displays ATPase and GTPase activities
I6I29_RS00045	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6I29_RS00050	COG1481	regulation of sporulation
I6I29_RS00070	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I29_RS00295	COG4824	toxin secretion phage lysis holin
I6I29_RS00320	COG0740	serine-type endopeptidase activity
I6I29_RS00330	COG1090	epimerase
I6I29_RS00350	COG0126	phosphoglycerate kinase activity
I6I29_RS00355	COG0149	triose-phosphate isomerase activity
I6I29_RS00360	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6I29_RS00365	COG0148	phosphopyruvate hydratase activity
I6I29_RS00380	COG3344	reverse transcriptase
I6I29_RS00390	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6I29_RS00395	COG1647	Serine aminopeptidase, S33
I6I29_RS00400	COG0557	exoribonuclease II activity
I6I29_RS00430	COG0346	lactoylglutathione lyase activity
I6I29_RS00450	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I29_RS00465	COG1764	response to oxidative stress
I6I29_RS00475	COG0710	3-dehydroquinate dehydratase activity
I6I29_RS00485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I29_RS00490	COG1393	Belongs to the ArsC family
I6I29_RS00500	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I6I29_RS00505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I29_RS00515	COG2011	ABC-type metal ion transport system permease component
I6I29_RS00520	COG1464	Belongs to the NlpA lipoprotein family
I6I29_RS00525	COG1464	Belongs to the NlpA lipoprotein family
I6I29_RS00540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I29_RS00545	COG3343	RNA polymerase activity
I6I29_RS00550	COG0504	CTP synthase activity
I6I29_RS00570	COG4821	SIS domain
I6I29_RS00575	COG0191	fructose-bisphosphate aldolase activity
I6I29_RS00580	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6I29_RS00585	COG1733	regulation of RNA biosynthetic process
I6I29_RS00595	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6I29_RS00600	COG0254	rRNA binding
I6I29_RS00610	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6I29_RS00615	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I29_RS00620	COG0009	L-threonylcarbamoyladenylate synthase
I6I29_RS00625	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I29_RS00630	COG4475	Protein of unknown function (DUF436)
I6I29_RS00635	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6I29_RS00640	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6I29_RS00645	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6I29_RS00655	COG0356	it plays a direct role in the translocation of protons across the membrane
I6I29_RS00660	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6I29_RS00670	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6I29_RS00680	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6I29_RS00710	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I29_RS00725	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6I29_RS00735	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6I29_RS00740	COG0352	thiamine-phosphate diphosphorylase activity
I6I29_RS00745	COG0706	membrane insertase activity
I6I29_RS00750	COG1418	mRNA catabolic process
I6I29_RS00755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I29_RS00760	COG1937	Protein conserved in bacteria
I6I29_RS00775	COG2217	Heavy metal translocating P-type atpase
I6I29_RS00795	COG0772	Belongs to the SEDS family
I6I29_RS00800	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I29_RS00805	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6I29_RS00810	COG0513	Belongs to the DEAD box helicase family
I6I29_RS00825	COG3402	PFAM membrane-flanked domain
I6I29_RS00830	COG0736	holo-[acyl-carrier-protein] synthase activity
I6I29_RS00835	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I29_RS00845	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6I29_RS00850	COG2208	phosphoserine phosphatase activity
I6I29_RS00855	COG1366	Belongs to the anti-sigma-factor antagonist family
I6I29_RS00865	COG1191	sigma factor activity
I6I29_RS00870	COG2183	response to ionizing radiation
I6I29_RS00875	COG3091	SprT-like family
I6I29_RS00920	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6I29_RS00930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I29_RS00935	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6I29_RS00945	COG0028	Belongs to the TPP enzyme family
I6I29_RS00950	COG0129	dihydroxy-acid dehydratase activity
I6I29_RS00955	COG0802	atpase or kinase
I6I29_RS00960	COG1214	PFAM Peptidase M22, glycoprotease
I6I29_RS00965	COG0456	acetyltransferase
I6I29_RS00970	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6I29_RS00980	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6I29_RS00985	COG0488	(ABC) transporter
I6I29_RS00990	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I6I29_RS00995	COG2814	Major facilitator Superfamily
I6I29_RS01000	COG1846	Transcriptional regulator
I6I29_RS01010	COG2124	cytochrome p450
I6I29_RS01015	COG1609	Transcriptional regulator
I6I29_RS01020	COG1621	beta-fructofuranosidase activity
I6I29_RS01025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I29_RS01045	COG4512	PFAM Accessory gene regulator B
I6I29_RS01085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I29_RS01090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I29_RS01110	COG1131	(ABC) transporter
I6I29_RS01125	COG1070	Carbohydrate kinase
I6I29_RS01130	COG2610	gluconate transmembrane transporter activity
I6I29_RS01165	COG2706	6-phosphogluconolactonase activity
I6I29_RS01170	COG1012	belongs to the aldehyde dehydrogenase family
I6I29_RS01180	COG1227	inorganic diphosphatase activity
I6I29_RS01185	COG1335	isochorismatase
I6I29_RS01195	COG1605	Chorismate mutase
I6I29_RS01195	COG0077	Prephenate dehydratase
I6I29_RS01205	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6I29_RS01215	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
I6I29_RS01225	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6I29_RS01230	COG4496	protein, YerC YecD
I6I29_RS01235	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
I6I29_RS01240	COG0210	DNA helicase
I6I29_RS01245	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6I29_RS01250	COG4851	CamS sex pheromone cAM373 precursor
I6I29_RS01255	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I29_RS01260	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I29_RS01270	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I29_RS01275	COG1597	lipid kinase activity
I6I29_RS01300	COG0488	(ABC) transporter
I6I29_RS01310	COG1396	sequence-specific DNA binding
I6I29_RS01330	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I29_RS01340	COG1528	Iron-storage protein
I6I29_RS01355	COG4129	membrane
I6I29_RS01360	COG0024	Methionine aminopeptidase
I6I29_RS01385	COG0288	reversible hydration of carbon dioxide
I6I29_RS01390	COG1295	ribonuclease BN
I6I29_RS01405	COG4840	Belongs to the UPF0435 family
I6I29_RS01410	COG2309	aminopeptidase activity
I6I29_RS01415	COG1607	acyl-coa hydrolase
I6I29_RS01420	COG0535	radical SAM domain protein
I6I29_RS01430	COG0693	protein deglycase activity
I6I29_RS01435	COG0028	Belongs to the TPP enzyme family
I6I29_RS01440	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I29_RS01445	COG2137	regulation of response to DNA damage stimulus
I6I29_RS01455	COG1388	LysM domain
I6I29_RS01455	COG1134	teichoic acid transport
I6I29_RS01465	COG1988	membrane-bound metal-dependent
I6I29_RS01470	COG1194	a g-specific adenine glycosylase
I6I29_RS01475	COG3557	Belongs to the UPF0374 family
I6I29_RS01485	COG0069	glutamate synthase activity
I6I29_RS01490	COG4129	membrane
I6I29_RS01495	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6I29_RS01500	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I29_RS01510	COG0735	belongs to the Fur family
I6I29_RS01735	COG0765	amino acid transport
I6I29_RS01740	COG1126	abc transporter atp-binding protein
I6I29_RS01745	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6I29_RS01755	COG0363	glucosamine-6-phosphate deaminase activity
I6I29_RS01770	COG0114	fumarate hydratase activity
I6I29_RS01775	COG0248	Ppx GppA phosphatase
I6I29_RS01780	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6I29_RS01785	COG0564	pseudouridine synthase activity
I6I29_RS01790	COG2203	Gaf domain
I6I29_RS01790	COG4585	Histidine kinase
I6I29_RS01795	COG2197	response regulator
I6I29_RS01805	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6I29_RS01815	COG4399	Belongs to the UPF0754 family
I6I29_RS01820	COG3679	Belongs to the UPF0342 family
I6I29_RS01825	COG0420	3'-5' exonuclease activity
I6I29_RS01835	COG3481	metal-dependent phosphohydrolase, HD sub domain
I6I29_RS01840	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I29_RS01855	COG1846	Transcriptional regulator
I6I29_RS01865	COG0537	adenosine 5'-monophosphoramidase activity
I6I29_RS01870	COG1131	(ABC) transporter
I6I29_RS01875	COG4473	ABC transporter
I6I29_RS01880	COG3344	reverse transcriptase
I6I29_RS01890	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6I29_RS01900	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6I29_RS01905	COG3545	Serine hydrolase
I6I29_RS01965	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I29_RS02085	COG0756	dUTP diphosphatase activity
I6I29_RS02140	COG4695	Portal protein
I6I29_RS02230	COG5632	N-Acetylmuramoyl-L-alanine amidase
I6I29_RS02230	COG1388	LysM domain
I6I29_RS02280	COG3037	sugar-specific permease SgaT UlaA
I6I29_RS02300	COG3623	hexulose-6-phosphate isomerase
I6I29_RS02305	COG0235	Class ii aldolase
I6I29_RS02325	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6I29_RS02330	COG0494	nUDIX hydrolase
I6I29_RS02335	COG1506	peptidase
I6I29_RS02340	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I6I29_RS02345	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6I29_RS02355	COG0656	L-ascorbic acid biosynthetic process
I6I29_RS02360	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I29_RS02365	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I29_RS02375	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I29_RS02400	COG5632	N-Acetylmuramoyl-L-alanine amidase
I6I29_RS02400	COG4193	domain, Protein
I6I29_RS02400	COG3266	domain, Protein
I6I29_RS02410	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I29_RS02410	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I29_RS02415	COG0307	riboflavin synthase, alpha
I6I29_RS02420	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6I29_RS02420	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6I29_RS02425	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6I29_RS02440	COG2267	carboxylic ester hydrolase activity
I6I29_RS02445	COG0039	L-malate dehydrogenase activity
I6I29_RS02455	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6I29_RS02460	COG1242	4 iron, 4 sulfur cluster binding
I6I29_RS02465	COG2814	Major facilitator Superfamily
I6I29_RS02470	COG0495	leucyl-tRNA aminoacylation
I6I29_RS02475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I29_RS02480	COG2081	HI0933 family
I6I29_RS02485	COG2244	polysaccharide biosynthetic process
I6I29_RS02490	COG1187	pseudouridine synthase activity
I6I29_RS02500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I29_RS02505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I29_RS02510	COG0510	thiamine kinase activity
I6I29_RS02515	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6I29_RS02520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I29_RS02530	COG1363	Peptidase, m42
I6I29_RS02535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I29_RS02540	COG4848	Belongs to the UPF0354 family
I6I29_RS02545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I29_RS02550	COG1674	ftsk spoiiie
I6I29_RS02555	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I29_RS02560	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
I6I29_RS02570	COG1605	Chorismate mutase
I6I29_RS02570	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I6I29_RS02575	COG1609	Transcriptional regulator
I6I29_RS02580	COG3344	reverse transcriptase
I6I29_RS02590	COG0454	-acetyltransferase
I6I29_RS02595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I29_RS02600	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6I29_RS02605	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6I29_RS02615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I29_RS02620	COG0204	Acyl-transferase
I6I29_RS02630	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I29_RS02635	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6I29_RS02640	COG1764	response to oxidative stress
I6I29_RS02680	COG0456	acetyltransferase
I6I29_RS02700	COG3344	reverse transcriptase
I6I29_RS02715	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6I29_RS02720	COG1956	GAF domain-containing protein
I6I29_RS02725	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I6I29_RS02730	COG1104	cysteine desulfurase activity
I6I29_RS02735	COG0301	tRNA thio-modification
I6I29_RS02745	COG0616	signal peptide processing
I6I29_RS02750	COG1714	RDD family
I6I29_RS02755	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6I29_RS02760	COG0827	DNA restriction-modification system
I6I29_RS02765	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6I29_RS02770	COG0589	response to stress
I6I29_RS02775	COG0686	Belongs to the AlaDH PNT family
I6I29_RS02785	COG0006	proline dipeptidase activity
I6I29_RS02790	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6I29_RS02800	COG4109	DRTGG domain
I6I29_RS02805	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6I29_RS02810	COG0587	DNA-directed DNA polymerase activity
I6I29_RS02815	COG0281	malic enzyme
I6I29_RS02820	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6I29_RS02825	COG0825	malonyl-CoA metabolic process
I6I29_RS02830	COG0205	6-phosphofructokinase activity
I6I29_RS02835	COG0469	pyruvate kinase activity
I6I29_RS02840	COG0372	Belongs to the citrate synthase family
I6I29_RS02845	COG0538	isocitrate dehydrogenase activity
I6I29_RS02850	COG0745	RESPONSE REGULATOR receiver
I6I29_RS02855	COG5002	protein histidine kinase activity
I6I29_RS02860	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I29_RS02860	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I29_RS02870	COG0237	dephospho-CoA kinase activity
I6I29_RS02885	COG3611	Membrane attachment protein
I6I29_RS02890	COG1484	DNA-dependent DNA replication
I6I29_RS02900	COG0833	amino acid
I6I29_RS02910	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6I29_RS02915	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6I29_RS02920	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6I29_RS02925	COG3344	reverse transcriptase
I6I29_RS02940	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6I29_RS02950	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6I29_RS02955	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6I29_RS02965	COG0181	hydroxymethylbilane synthase activity
I6I29_RS02980	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6I29_RS02990	COG2818	Glycosylase
I6I29_RS02995	COG0525	valine-tRNA ligase activity
I6I29_RS03000	COG0285	dihydrofolate synthase activity
I6I29_RS03010	COG2003	Belongs to the UPF0758 family
I6I29_RS03045	COG2868	ribosomal protein
I6I29_RS03055	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6I29_RS03065	COG0632	four-way junction helicase activity
I6I29_RS03075	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6I29_RS03085	COG1862	Preprotein translocase
I6I29_RS03090	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I29_RS03090	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I29_RS03095	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6I29_RS03095	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6I29_RS03100	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I29_RS03110	COG1490	D-aminoacyl-tRNA deacylase activity
I6I29_RS03115	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I29_RS03125	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6I29_RS03135	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6I29_RS03140	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6I29_RS03145	COG1959	2 iron, 2 sulfur cluster binding
I6I29_RS03160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I29_RS03165	COG1104	cysteine desulfurase activity
I6I29_RS03170	COG0482	sulfurtransferase activity
I6I29_RS03180	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I29_RS03185	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I29_RS03190	COG4472	Bacterial protein of unknown function (DUF965)
I6I29_RS03195	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6I29_RS03200	COG3906	Belongs to the UPF0473 family
I6I29_RS03205	COG4122	O-methyltransferase activity
I6I29_RS03210	COG0826	peptidase U32
I6I29_RS03215	COG0826	peptidase U32
I6I29_RS03220	COG0572	uridine kinase
I6I29_RS03230	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6I29_RS03235	COG1984	allophanate hydrolase subunit 2
I6I29_RS03240	COG0511	ligase activity, forming carbon-carbon bonds
I6I29_RS03245	COG0439	Biotin carboxylase
I6I29_RS03250	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6I29_RS03255	COG1914	H( )-stimulated, divalent metal cation uptake system
I6I29_RS03260	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6I29_RS03265	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I6I29_RS03270	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6I29_RS03275	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I29_RS03280	COG1534	Rna-binding protein
I6I29_RS03290	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6I29_RS03295	COG0799	negative regulation of ribosome biogenesis
I6I29_RS03300	COG2226	methyltransferase
I6I29_RS03305	COG1596	polysaccharide export
I6I29_RS03305	COG1555	photosystem II stabilization
I6I29_RS03310	COG2131	deaminase
I6I29_RS03315	COG2333	competence protein COMEC
I6I29_RS03315	COG0658	competence protein
I6I29_RS03320	COG1466	dna polymerase III delta subunit
I6I29_RS03325	COG0268	Binds directly to 16S ribosomal RNA
I6I29_RS03335	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I29_RS03355	COG0484	heat shock protein binding
I6I29_RS03360	COG2264	protein methyltransferase activity
I6I29_RS03365	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6I29_RS03370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I29_RS03385	COG1030	water channel activity
I6I29_RS03390	COG4864	UPF0365 protein
I6I29_RS03400	COG1702	phosphate starvation-inducible protein PhoH
I6I29_RS03410	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6I29_RS03420	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6I29_RS03425	COG1381	Involved in DNA repair and RecF pathway recombination
I6I29_RS03430	COG0423	glycine-tRNA ligase activity
I6I29_RS03435	COG0517	IMP dehydrogenase activity
I6I29_RS03440	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6I29_RS03445	COG0358	DNA primase activity
I6I29_RS03450	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6I29_RS03455	COG2384	SAM-dependent methyltransferase
I6I29_RS03460	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6I29_RS03465	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6I29_RS03470	COG0513	Belongs to the DEAD box helicase family
I6I29_RS03475	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6I29_RS03480	COG1121	(ABC) transporter
I6I29_RS03485	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I29_RS03490	COG0735	belongs to the Fur family
I6I29_RS03495	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6I29_RS03505	COG0768	penicillin binding
I6I29_RS03510	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6I29_RS03515	COG0573	inorganic phosphate transmembrane transporter activity
I6I29_RS03520	COG0581	inorganic phosphate transmembrane transporter activity
I6I29_RS03525	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6I29_RS03530	COG0704	Plays a role in the regulation of phosphate uptake
I6I29_RS03540	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6I29_RS03545	COG0705	Rhomboid family
I6I29_RS03550	COG4483	Protein conserved in bacteria
I6I29_RS03555	COG1940	carbohydrate kinase activity
I6I29_RS03560	COG0011	TIGRFAM Protein of
I6I29_RS03565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I29_RS03575	COG0582	viral genome integration into host DNA
I6I29_RS03670	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I29_RS03830	COG4824	toxin secretion phage lysis holin
I6I29_RS03865	COG3969	phosphoadenosine phosphosulfate
I6I29_RS03870	COG1475	DNA binding
I6I29_RS03905	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6I29_RS03910	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6I29_RS03920	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I29_RS03925	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I29_RS03930	COG0095	Lipoate-protein ligase
I6I29_RS03945	COG0006	proline dipeptidase activity
I6I29_RS03950	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I29_RS03955	COG0511	ligase activity, forming carbon-carbon bonds
I6I29_RS03960	COG0439	Biotin carboxylase
I6I29_RS03965	COG1302	Protein conserved in bacteria
I6I29_RS03975	COG1570	exodeoxyribonuclease VII activity
I6I29_RS03980	COG1722	exodeoxyribonuclease VII activity
I6I29_RS03990	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6I29_RS03995	COG1438	arginine binding
I6I29_RS04000	COG0497	DNA recombination
I6I29_RS04005	COG0280	phosphate acetyltransferase
I6I29_RS04010	COG3426	butyrate kinase activity
I6I29_RS04015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I29_RS04020	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6I29_RS04025	COG0022	dehydrogenase e1 component
I6I29_RS04030	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I29_RS04040	COG4129	membrane
I6I29_RS04050	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6I29_RS04080	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6I29_RS04085	COG1234	tRNA 3'-trailer cleavage
I6I29_RS04090	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6I29_RS04100	COG0667	Aldo Keto reductase
I6I29_RS04105	COG0494	nUDIX hydrolase
I6I29_RS04110	COG0735	belongs to the Fur family
I6I29_RS04125	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6I29_RS04130	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6I29_RS04135	COG1187	pseudouridine synthase activity
I6I29_RS04140	COG0745	RESPONSE REGULATOR receiver
I6I29_RS04155	COG1141	Ferredoxin
I6I29_RS04165	COG0514	ATP-dependent DNA helicase (RecQ)
I6I29_RS04175	COG0492	ferredoxin-NADP+ reductase activity
I6I29_RS04180	COG0252	asparaginase activity
I6I29_RS04190	COG0539	negative regulation of cytoplasmic translation
I6I29_RS04195	COG3344	reverse transcriptase
I6I29_RS04200	COG1160	GTP binding
I6I29_RS04205	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6I29_RS04225	COG0142	geranyltranstransferase activity
I6I29_RS04230	COG0105	UTP biosynthetic process
I6I29_RS04240	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6I29_RS04250	COG0457	Tetratricopeptide repeat
I6I29_RS04255	COG5582	Belongs to the UPF0302 family
I6I29_RS04260	COG4347	Protein of unknown function (DUF1405)
I6I29_RS04270	COG1694	Mazg nucleotide pyrophosphohydrolase
I6I29_RS04275	COG0438	transferase activity, transferring glycosyl groups
I6I29_RS04280	COG0617	tRNA 3'-terminal CCA addition
I6I29_RS04295	COG0017	Asparaginyl-tRNA synthetase
I6I29_RS04305	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6I29_RS04315	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6I29_RS04315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I29_RS04330	COG4474	Belongs to the UPF0398 family
I6I29_RS04335	COG3599	regulation of cell shape
I6I29_RS04345	COG0116	Belongs to the methyltransferase superfamily
I6I29_RS04350	COG2962	Rard protein
I6I29_RS04355	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6I29_RS04360	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I29_RS04370	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6I29_RS04380	COG1413	lyase activity
I6I29_RS04415	COG2190	(PTS) system
I6I29_RS04425	COG0793	Belongs to the peptidase S41A family
I6I29_RS04440	COG0671	phosphoesterase, PA-phosphatase related
I6I29_RS04450	COG5002	protein histidine kinase activity
I6I29_RS04455	COG0567	Dehydrogenase, E1 component
I6I29_RS04480	COG0714	Associated with various cellular activities
I6I29_RS04485	COG4548	von Willebrand factor, type A
I6I29_RS04490	COG1114	Component of the transport system for branched-chain amino acids
I6I29_RS04495	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I29_RS04505	COG3853	Toxic anion resistance protein (TelA)
I6I29_RS04525	COG1278	Cold shock
I6I29_RS04545	COG1473	amidohydrolase
I6I29_RS04550	COG2171	N-acyltransferase activity
I6I29_RS04555	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6I29_RS04560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I29_RS04565	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6I29_RS04570	COG0488	(ABC) transporter
I6I29_RS04575	COG2996	Protein conserved in bacteria
I6I29_RS04605	COG1363	Peptidase, m42
I6I29_RS04610	COG0287	Prephenate dehydrogenase
I6I29_RS04615	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I29_RS04625	COG1942	4-Oxalocrotonate Tautomerase
I6I29_RS04645	COG0628	permease
I6I29_RS04655	COG3711	transcriptional antiterminator
I6I29_RS04660	COG1115	amino acid carrier protein
I6I29_RS04665	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6I29_RS04675	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6I29_RS04680	COG4841	protein insertion into membrane
I6I29_RS04685	COG0824	Thioesterase
I6I29_RS04695	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I29_RS04700	COG1970	mechanosensitive ion channel activity
I6I29_RS04705	COG0419	ATPase involved in DNA repair
I6I29_RS04710	COG0420	3'-5' exonuclease activity
I6I29_RS04715	COG4846	Membrane protein involved in cytochrome C biogenesis
I6I29_RS04720	COG3763	UPF0154 protein
I6I29_RS04730	COG4224	UPF0291 protein
I6I29_RS04740	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I29_RS04750	COG0516	GMP reductase activity
I6I29_RS04755	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6I29_RS04765	COG0833	amino acid
I6I29_RS04780	COG0083	homoserine kinase activity
I6I29_RS04785	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6I29_RS04790	COG0460	homoserine dehydrogenase
I6I29_RS04795	COG0527	aspartate kinase activity
I6I29_RS04815	COG1525	nuclease
I6I29_RS04845	COG0584	glycerophosphoryl diester phosphodiesterase
I6I29_RS04920	COG3344	reverse transcriptase
I6I29_RS04930	COG0789	Transcriptional regulator
I6I29_RS04935	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I6I29_RS04940	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6I29_RS04945	COG0386	Belongs to the glutathione peroxidase family
I6I29_RS04955	COG2267	carboxylic ester hydrolase activity
I6I29_RS04960	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6I29_RS04965	COG1923	regulation of RNA biosynthetic process
I6I29_RS04970	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6I29_RS04980	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6I29_RS04985	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6I29_RS04990	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I6I29_RS04995	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6I29_RS05015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I29_RS05025	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6I29_RS05030	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6I29_RS05030	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6I29_RS05035	COG1692	metallophosphoesterase
I6I29_RS05055	COG1418	mRNA catabolic process
I6I29_RS05060	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6I29_RS05065	COG1058	Belongs to the CinA family
I6I29_RS05065	COG1546	Belongs to the CinA family
I6I29_RS05085	COG0300	oxidoreductase activity
I6I29_RS05090	COG0612	Peptidase, M16
I6I29_RS05095	COG0612	Peptidase, M16
I6I29_RS05100	COG2188	Transcriptional regulator
I6I29_RS05115	COG1185	polyribonucleotide nucleotidyltransferase activity
I6I29_RS05125	COG0196	riboflavin kinase activity
I6I29_RS05130	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6I29_RS05135	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6I29_RS05145	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6I29_RS05150	COG1358	cellular component organization or biogenesis
I6I29_RS05155	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6I29_RS05160	COG0195	Participates in both transcription termination and antitermination
I6I29_RS05165	COG0779	Required for maturation of 30S ribosomal subunits
I6I29_RS05175	COG0442	prolyl-tRNA aminoacylation
I6I29_RS05185	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6I29_RS05190	COG4589	Belongs to the CDS family
I6I29_RS05200	COG0233	cytoplasmic translational termination
I6I29_RS05205	COG0528	UMP kinase activity
I6I29_RS05210	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6I29_RS05215	COG0052	Belongs to the universal ribosomal protein uS2 family
I6I29_RS05220	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I6I29_RS05225	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I6I29_RS05230	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6I29_RS05235	COG4974	Belongs to the 'phage' integrase family
I6I29_RS05240	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I6I29_RS05245	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6I29_RS05250	COG0758	DNA mediated transformation
I6I29_RS05260	COG0045	succinate-CoA ligase (ADP-forming) activity
I6I29_RS05270	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6I29_RS05285	COG4485	Bacterial membrane protein, YfhO
I6I29_RS05320	COG0336	Belongs to the RNA methyltransferase TrmD family
I6I29_RS05325	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6I29_RS05330	COG0228	four-way junction DNA binding
I6I29_RS05350	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6I29_RS05365	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6I29_RS05370	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I6I29_RS05375	COG0552	protein localization to endoplasmic reticulum
I6I29_RS05380	COG1196	nuclear chromosome segregation
I6I29_RS05385	COG0571	ribonuclease III activity
I6I29_RS05390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I29_RS05405	COG0416	fatty acid biosynthetic process
I6I29_RS05410	COG1349	DNA-binding transcription factor activity
I6I29_RS05420	COG1760	l-serine dehydratase
I6I29_RS05425	COG1760	l-serine dehydratase
I6I29_RS05435	COG1302	Protein conserved in bacteria
I6I29_RS05450	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6I29_RS05455	COG1162	GTPase activity
I6I29_RS05460	COG2124	cytochrome p450
I6I29_RS05475	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6I29_RS05480	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6I29_RS05480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I29_RS05485	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I29_RS05490	COG0242	peptide deformylase activity
I6I29_RS05495	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6I29_RS05500	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6I29_RS05520	COG1758	RNA polymerase activity
I6I29_RS05540	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6I29_RS05545	COG0284	orotidine-5'-phosphate decarboxylase activity
I6I29_RS05550	COG0167	dihydroorotate dehydrogenase activity
I6I29_RS05560	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6I29_RS05565	COG0505	Belongs to the CarA family
I6I29_RS05585	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I6I29_RS05590	COG0564	pseudouridine synthase activity
I6I29_RS05595	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6I29_RS05600	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6I29_RS05605	COG3599	regulation of cell shape
I6I29_RS05620	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I29_RS05625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I29_RS05635	COG4975	Glucose uptake
I6I29_RS05640	COG1869	D-ribose catabolic process
I6I29_RS05645	COG0762	integral membrane protein
I6I29_RS05650	COG1799	cell septum assembly
I6I29_RS05655	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6I29_RS05665	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6I29_RS05670	COG0849	cell division
I6I29_RS05680	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6I29_RS05690	COG0768	penicillin binding
I6I29_RS05695	COG4839	cell division protein FtsL
I6I29_RS05700	COG0275	rRNA processing
I6I29_RS05705	COG2001	Belongs to the MraZ family
I6I29_RS05710	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
I6I29_RS05715	COG0454	-acetyltransferase
I6I29_RS05720	COG1011	Hydrolase
I6I29_RS05735	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I29_RS05795	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6I29_RS05800	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6I29_RS05805	COG1053	succinate dehydrogenase
I6I29_RS05810	COG2009	succinate dehydrogenase
I6I29_RS05815	COG0322	excinuclease ABC activity
I6I29_RS05820	COG3118	belongs to the thioredoxin family
I6I29_RS05825	COG1193	negative regulation of DNA recombination
I6I29_RS05830	COG1796	DNA polymerase
I6I29_RS05830	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6I29_RS05845	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6I29_RS05860	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6I29_RS05865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I29_RS05870	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6I29_RS05890	COG0742	ribosomal rna small subunit methyltransferase
I6I29_RS05900	COG4471	UPF0298 protein
I6I29_RS05905	COG0584	glycerophosphoryl diester phosphodiesterase
I6I29_RS05910	COG3679	Belongs to the UPF0342 family
I6I29_RS05925	COG0109	protoheme IX farnesyltransferase activity
I6I29_RS05945	COG3344	reverse transcriptase
I6I29_RS05950	COG0772	Belongs to the SEDS family
I6I29_RS05955	COG4838	Belongs to the UPF0358 family
I6I29_RS05960	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6I29_RS05965	COG4896	Protein conserved in bacteria
I6I29_RS05970	COG1902	pentaerythritol trinitrate reductase activity
I6I29_RS05975	COG1217	gtp-binding protein TYPA
I6I29_RS05985	COG0483	inositol monophosphate 1-phosphatase activity
I6I29_RS05990	COG4493	Belongs to the UPF0637 family
I6I29_RS06005	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6I29_RS06010	COG1177	transmembrane transport
I6I29_RS06020	COG3842	ATPase activity
I6I29_RS06030	COG4476	Belongs to the UPF0223 family
I6I29_RS06070	COG5503	Protein of unknown function (DUF1447)
I6I29_RS06075	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6I29_RS06085	COG0492	ferredoxin-NADP+ reductase activity
I6I29_RS06110	COG0569	domain protein
I6I29_RS06115	COG1294	oxidase, subunit
I6I29_RS06120	COG1271	oxidase subunit
I6I29_RS06125	COG1393	Belongs to the ArsC family
I6I29_RS06130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I29_RS06135	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I29_RS06145	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6I29_RS06165	COG4172	Belongs to the ABC transporter superfamily
I6I29_RS06175	COG0151	Belongs to the GarS family
I6I29_RS06180	COG0138	bifunctional purine biosynthesis protein purh
I6I29_RS06190	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6I29_RS06195	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6I29_RS06205	COG0047	phosphoribosylformylglycinamidine synthase activity
I6I29_RS06210	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I29_RS06215	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6I29_RS06220	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6I29_RS06225	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6I29_RS06230	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6I29_RS06235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I29_RS06235	COG1017	nitric oxide dioxygenase activity
I6I29_RS06245	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6I29_RS06255	COG1845	cytochrome c oxidase, subunit III
I6I29_RS06260	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6I29_RS06270	COG3973	AAA domain
I6I29_RS06310	COG3212	peptidase
I6I29_RS06325	COG1134	teichoic acid transport
I6I29_RS06335	COG1682	transport, permease protein
I6I29_RS06345	COG1215	transferase activity, transferring glycosyl groups
I6I29_RS06355	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6I29_RS06360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I29_RS06365	COG1316	TRANSCRIPTIONal
I6I29_RS06390	COG3594	Acyltransferase
I6I29_RS06395	COG0436	Aminotransferase
I6I29_RS06400	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6I29_RS06410	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6I29_RS06415	COG1169	isochorismate synthase
I6I29_RS06420	COG1575	Belongs to the MenA family. Type 1 subfamily
I6I29_RS06425	COG0390	transport system, permease component
I6I29_RS06430	COG4619	ABC transporter
I6I29_RS06450	COG4873	Protein conserved in bacteria
I6I29_RS06500	COG2378	regulation of single-species biofilm formation
I6I29_RS06510	COG0456	acetyltransferase
I6I29_RS06520	COG2226	methyltransferase
I6I29_RS06605	COG0737	Belongs to the 5'-nucleotidase family
I6I29_RS06615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I29_RS06620	COG1696	Membrane protein involved in D-alanine export
I6I29_RS06630	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I6I29_RS06635	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I29_RS06640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I29_RS06645	COG0861	Integral membrane protein TerC family
I6I29_RS06650	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6I29_RS06660	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I29_RS06665	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I29_RS06670	COG2814	Major facilitator Superfamily
I6I29_RS06680	COG3715	PTS system
I6I29_RS06685	COG3716	PTS system mannose fructose sorbose family IID component
I6I29_RS06690	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6I29_RS06695	COG2382	esterase
I6I29_RS06700	COG1115	amino acid carrier protein
I6I29_RS06705	COG0628	permease
I6I29_RS06710	COG4409	exo-alpha-(2->6)-sialidase activity
I6I29_RS06715	COG2211	Major facilitator Superfamily
I6I29_RS06720	COG0673	inositol 2-dehydrogenase activity
I6I29_RS06730	COG0569	domain protein
I6I29_RS06730	COG0475	glutathione-regulated potassium exporter activity
I6I29_RS06735	COG2239	Acts as a magnesium transporter
I6I29_RS06740	COG0564	pseudouridine synthase activity
I6I29_RS06750	COG2357	RelA SpoT domain protein
I6I29_RS06765	COG2346	COG2346, Truncated hemoglobins
I6I29_RS06770	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6I29_RS06780	COG1164	Oligoendopeptidase f
I6I29_RS06805	COG1393	Belongs to the ArsC family
I6I29_RS06810	COG0180	Tryptophanyl-tRNA synthetase
I6I29_RS06815	COG4166	transmembrane transport
I6I29_RS06820	COG4608	Belongs to the ABC transporter superfamily
I6I29_RS06825	COG0444	Belongs to the ABC transporter superfamily
I6I29_RS06830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I29_RS06835	COG0601	transmembrane transport
I6I29_RS06860	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I6I29_RS06880	COG0561	phosphatase activity
I6I29_RS06885	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I29_RS06900	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I29_RS06910	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I6I29_RS06925	COG0166	Belongs to the GPI family
I6I29_RS06930	COG0137	argininosuccinate synthase activity
I6I29_RS06940	COG0584	glycerophosphoryl diester phosphodiesterase
I6I29_RS06955	COG1012	belongs to the aldehyde dehydrogenase family
I6I29_RS06960	COG1098	S1 RNA binding domain
I6I29_RS06970	COG1278	Cold shock
I6I29_RS07015	COG1131	(ABC) transporter
I6I29_RS07045	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6I29_RS07055	COG2111	Na H antiporter
I6I29_RS07055	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I29_RS07060	COG2111	Na H antiporter
I6I29_RS07065	COG1006	Multisubunit Na H antiporter MnhC subunit
I6I29_RS07070	COG0651	ATP synthesis coupled electron transport
I6I29_RS07075	COG1863	multisubunit Na H antiporter MnhE subunit
I6I29_RS07080	COG2212	antiporter activity
I6I29_RS07085	COG1320	monovalent cation:proton antiporter activity
I6I29_RS07095	COG2056	Na+-H+ antiporter family
I6I29_RS07100	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6I29_RS07105	COG1252	NADH dehydrogenase
I6I29_RS07110	COG0316	Belongs to the HesB IscA family
I6I29_RS07115	COG4844	belongs to the
I6I29_RS07120	COG1252	NADH dehydrogenase
I6I29_RS07125	COG4837	Protein of unknown function (DUF1462)
I6I29_RS07130	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6I29_RS07135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I29_RS07140	COG0647	UMP catabolic process
I6I29_RS07145	COG2445	Protein of unknown function DUF86
I6I29_RS07155	COG4470	Protein conserved in bacteria
I6I29_RS07160	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I29_RS07165	COG0737	Belongs to the 5'-nucleotidase family
I6I29_RS07170	COG0730	response to heat
I6I29_RS07175	COG1801	Protein of unknown function DUF72
I6I29_RS07190	COG1253	flavin adenine dinucleotide binding
I6I29_RS07200	COG5632	N-Acetylmuramoyl-L-alanine amidase
I6I29_RS07200	COG1388	LysM domain
I6I29_RS07320	COG3728	DNA packaging
I6I29_RS07320	COG5484	DNA packaging
I6I29_RS07480	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I29_RS07625	COG1783	phage Terminase large subunit
I6I29_RS07630	COG3728	DNA packaging
I6I29_RS07630	COG5484	DNA packaging
I6I29_RS07655	COG0756	dUTP diphosphatase activity
I6I29_RS07730	COG0305	Participates in initiation and elongation during chromosome replication
I6I29_RS07830	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I29_RS07860	COG0719	Fe-S assembly protein
I6I29_RS07865	COG0822	iron-sulfur transferase activity
I6I29_RS07875	COG0719	Fe-S assembly protein
I6I29_RS07880	COG0396	ATPase activity
I6I29_RS07895	COG5146	pantothenate kinase activity
I6I29_RS07930	COG0813	purine-nucleoside phosphorylase activity
I6I29_RS07940	COG1757	Na H antiporter
I6I29_RS07945	COG3344	reverse transcriptase
I6I29_RS07960	COG1482	cell wall glycoprotein biosynthetic process
I6I29_RS07965	COG2186	Transcriptional regulator
I6I29_RS07975	COG0561	phosphatase activity
I6I29_RS07980	COG1119	ATPase activity
I6I29_RS08000	COG3711	transcriptional antiterminator
I6I29_RS08015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I29_RS08080	COG0489	protein tyrosine kinase activity
I6I29_RS08085	COG2814	Major facilitator Superfamily
I6I29_RS08105	COG1272	protein, Hemolysin III
I6I29_RS08110	COG4284	Utp--glucose-1-phosphate uridylyltransferase
I6I29_RS08115	COG1988	membrane-bound metal-dependent
I6I29_RS08125	COG3314	Sporulation integral membrane protein YlbJ
I6I29_RS08130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I29_RS08135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I29_RS08140	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6I29_RS08145	COG3457	Alanine racemase
I6I29_RS08150	COG4264	IucA IucC family
I6I29_RS08155	COG2814	Major facilitator Superfamily
I6I29_RS08160	COG4264	IucA IucC family
I6I29_RS08165	COG2814	Major facilitator Superfamily
I6I29_RS08170	COG1302	Protein conserved in bacteria
I6I29_RS08185	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I29_RS08195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I29_RS08200	COG0488	(ABC) transporter
I6I29_RS08210	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I29_RS08210	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6I29_RS08220	COG3684	Belongs to the aldolase LacD family
I6I29_RS08235	COG1349	DNA-binding transcription factor activity
I6I29_RS08275	COG3344	reverse transcriptase
I6I29_RS08280	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6I29_RS08300	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6I29_RS08305	COG0101	tRNA pseudouridine synthase activity
I6I29_RS08315	COG1122	ATPase activity
I6I29_RS08320	COG1122	ATPase activity
I6I29_RS08325	COG0203	ribosomal protein L17
I6I29_RS08330	COG0202	RNA polymerase activity
I6I29_RS08335	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6I29_RS08345	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I29_RS08360	COG0201	protein transport
I6I29_RS08370	COG1841	ribosomal large subunit assembly
I6I29_RS08375	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6I29_RS08385	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6I29_RS08390	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6I29_RS08395	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6I29_RS08410	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6I29_RS08420	COG0255	Belongs to the universal ribosomal protein uL29 family
I6I29_RS08425	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6I29_RS08430	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6I29_RS08435	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6I29_RS08440	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6I29_RS08445	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6I29_RS08450	COG0089	rRNA binding
I6I29_RS08455	COG0088	Forms part of the polypeptide exit tunnel
I6I29_RS08460	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6I29_RS08480	COG2252	PERMEase
I6I29_RS08510	COG0436	Aminotransferase
I6I29_RS08515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I29_RS08520	COG2348	transferase activity, transferring amino-acyl groups
I6I29_RS08545	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6I29_RS08550	COG0746	molybdenum cofactor guanylyltransferase activity
I6I29_RS08560	COG0314	molybdopterin synthase activity
I6I29_RS08580	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6I29_RS08585	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6I29_RS08590	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6I29_RS08595	COG4149	molybdate abc transporter
I6I29_RS08605	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I6I29_RS08610	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I29_RS08615	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6I29_RS08620	COG1609	Transcriptional regulator
I6I29_RS08635	COG1268	BioY protein
I6I29_RS08645	COG2186	Transcriptional regulator
I6I29_RS08655	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I29_RS08660	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I29_RS08665	COG2832	Protein of unknown function (DUF454)
I6I29_RS08670	COG1960	acyl-CoA dehydrogenase activity
I6I29_RS08690	COG3942	CHAP domain
I6I29_RS08700	COG1757	Na H antiporter
I6I29_RS08710	COG3942	CHAP domain
I6I29_RS08715	COG2076	Multidrug Resistance protein
I6I29_RS08720	COG2076	Multidrug Resistance protein
I6I29_RS08725	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I29_RS08750	COG3383	formate dehydrogenase (NAD+) activity
I6I29_RS08755	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I6I29_RS08770	COG1316	TRANSCRIPTIONal
I6I29_RS08795	COG1113	amino acid transport
I6I29_RS08820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6I29_RS08825	COG0346	lactoylglutathione lyase activity
I6I29_RS08835	COG0385	Bile acid
I6I29_RS08855	COG1473	amidohydrolase
I6I29_RS08860	COG0659	secondary active sulfate transmembrane transporter activity
I6I29_RS08865	COG1228	amidohydrolase
I6I29_RS08870	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6I29_RS08875	COG3314	Sporulation integral membrane protein YlbJ
I6I29_RS08880	COG0583	DNA-binding transcription factor activity
I6I29_RS08885	COG1266	CAAX protease self-immunity
I6I29_RS08895	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6I29_RS08900	COG2258	MOSC domain
I6I29_RS08905	COG2017	converts alpha-aldose to the beta-anomer
I6I29_RS08910	COG1742	UPF0060 membrane protein
I6I29_RS08915	COG1668	transmembrane transport
I6I29_RS08920	COG4152	abc transporter atp-binding protein
I6I29_RS08925	COG3152	Membrane
I6I29_RS08930	COG2094	Belongs to the DNA glycosylase MPG family
I6I29_RS08935	COG1757	Na H antiporter
I6I29_RS08960	COG2207	Transcriptional regulator
I6I29_RS08965	COG0786	glutamate:sodium symporter activity
I6I29_RS08970	COG0523	cobalamin synthesis protein
I6I29_RS08975	COG1304	FMN binding
I6I29_RS08995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I29_RS09005	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6I29_RS09015	COG3344	reverse transcriptase
I6I29_RS09045	COG0577	efflux transmembrane transporter activity
I6I29_RS09060	COG0579	oxidoreductase
I6I29_RS09065	COG0438	transferase activity, transferring glycosyl groups
I6I29_RS09070	COG1620	l-lactate permease
I6I29_RS09085	COG0604	alcohol dehydrogenase
I6I29_RS09090	COG2814	Major facilitator Superfamily
I6I29_RS09095	COG0492	ferredoxin-NADP+ reductase activity
I6I29_RS09115	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6I29_RS09130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I29_RS09130	COG1263	PTS System
I6I29_RS09140	COG2807	transmembrane transport
I6I29_RS09150	COG0697	spore germination
I6I29_RS09155	COG1363	Peptidase, m42
I6I29_RS09160	COG0039	L-malate dehydrogenase activity
I6I29_RS09170	COG4187	Peptidase family M20/M25/M40
I6I29_RS09175	COG3344	reverse transcriptase
I6I29_RS09180	COG2223	nitrite transmembrane transporter activity
I6I29_RS09185	COG2197	response regulator
I6I29_RS09190	COG4585	Histidine kinase
I6I29_RS09200	COG2181	nitrate reductase activity
I6I29_RS09210	COG1140	nitrate reductase beta subunit
I6I29_RS09215	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6I29_RS09230	COG0018	arginyl-trna synthetase
I6I29_RS09240	COG0737	Belongs to the 5'-nucleotidase family
I6I29_RS09245	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I29_RS09245	COG1648	precorrin-2 dehydrogenase activity
I6I29_RS09250	COG2146	nitrite reductase [NAD(P)H] activity
I6I29_RS09255	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I29_RS09260	COG1648	precorrin-2 dehydrogenase activity
I6I29_RS09260	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I29_RS09270	COG0454	-acetyltransferase
I6I29_RS09275	COG2116	formate transmembrane transporter activity
I6I29_RS09280	COG0471	metal ion transport
I6I29_RS09330	COG1760	l-serine dehydratase
I6I29_RS09335	COG1760	l-serine dehydratase
I6I29_RS09345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I29_RS09350	COG0601	transmembrane transport
I6I29_RS09355	COG4608	Belongs to the ABC transporter superfamily
I6I29_RS09360	COG0444	Belongs to the ABC transporter superfamily
I6I29_RS09365	COG4166	transmembrane transport
I6I29_RS09370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I29_RS09375	COG0601	transmembrane transport
I6I29_RS09380	COG4608	Belongs to the ABC transporter superfamily
I6I29_RS09385	COG0444	Belongs to the ABC transporter superfamily
I6I29_RS09390	COG4166	transmembrane transport
I6I29_RS09395	COG0702	epimerase
I6I29_RS09400	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6I29_RS09420	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
I6I29_RS09430	COG1929	Belongs to the glycerate kinase type-1 family
I6I29_RS09435	COG3764	Sortase (surface protein transpeptidase)
I6I29_RS09440	COG2271	Major facilitator Superfamily
I6I29_RS09445	COG2814	Major facilitator Superfamily
I6I29_RS09450	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
I6I29_RS09455	COG1115	amino acid carrier protein
I6I29_RS09460	COG3871	stress protein (general stress protein 26)
I6I29_RS09465	COG0789	Transcriptional regulator
I6I29_RS09470	COG1132	(ABC) transporter
I6I29_RS09475	COG1132	(ABC) transporter
I6I29_RS09480	COG0247	lactate metabolic process
I6I29_RS09485	COG0277	FAD linked oxidase domain protein
I6I29_RS09505	COG0159	tryptophan synthase activity
I6I29_RS09510	COG0133	tryptophan synthase activity
I6I29_RS09520	COG0134	indole-3-glycerol-phosphate synthase activity
I6I29_RS09530	COG0512	Glutamine amidotransferase of anthranilate synthase
I6I29_RS09535	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6I29_RS09540	COG3961	Belongs to the TPP enzyme family
I6I29_RS09545	COG2855	membrane
I6I29_RS09550	COG3835	regulator
I6I29_RS09565	COG1028	Short-chain dehydrogenase reductase Sdr
I6I29_RS09605	COG2357	RelA SpoT domain protein
I6I29_RS09610	COG0778	Nitroreductase
I6I29_RS09615	COG1846	Transcriptional regulator
I6I29_RS09630	COG1346	cytolysis
I6I29_RS09640	COG0583	DNA-binding transcription factor activity
I6I29_RS09665	COG1141	Ferredoxin
I6I29_RS09675	COG0523	cobalamin synthesis protein
I6I29_RS09680	COG0717	Belongs to the dCTP deaminase family
I6I29_RS09685	COG0804	urea catabolic process
I6I29_RS09690	COG0832	Belongs to the urease beta subunit family
I6I29_RS09700	COG4413	Urea transporter
I6I29_RS09710	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I6I29_RS09720	COG0577	efflux transmembrane transporter activity
I6I29_RS09725	COG1136	(ABC) transporter
I6I29_RS09750	COG3001	Fructosamine kinase
I6I29_RS09755	COG0778	Nitroreductase
I6I29_RS09770	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6I29_RS09770	COG0463	Glycosyl transferase, family 2
I6I29_RS09795	COG0747	negative chemotaxis
I6I29_RS09800	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6I29_RS09805	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6I29_RS09815	COG3942	CHAP domain
I6I29_RS09815	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6I29_RS09825	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I29_RS09825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I29_RS09825	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I29_RS09830	COG0789	Transcriptional regulator
I6I29_RS09835	COG0596	Alpha beta hydrolase
I6I29_RS09850	COG1012	belongs to the aldehyde dehydrogenase family
I6I29_RS09855	COG2824	Alkylphosphonate utilization operon protein PhnA
I6I29_RS09860	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I6I29_RS09865	COG1461	Dihydroxyacetone kinase
I6I29_RS09870	COG2376	Dihydroxyacetone kinase
I6I29_RS09910	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I6I29_RS09915	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6I29_RS09920	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6I29_RS09925	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I29_RS09940	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6I29_RS09945	COG0107	imidazoleglycerol-phosphate synthase activity
I6I29_RS09960	COG0156	8-amino-7-oxononanoate synthase activity
I6I29_RS09970	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6I29_RS09975	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6I29_RS09980	COG1012	belongs to the aldehyde dehydrogenase family
I6I29_RS09985	COG1510	regulation of RNA biosynthetic process
I6I29_RS10000	COG0556	nucleotide-excision repair
I6I29_RS10005	COG0494	nUDIX hydrolase
I6I29_RS10010	COG1785	Belongs to the alkaline phosphatase family
I6I29_RS10025	COG1396	sequence-specific DNA binding
I6I29_RS10030	COG2807	transmembrane transport
I6I29_RS10035	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I6I29_RS10040	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I6I29_RS10070	COG1957	nucleoside hydrolase
I6I29_RS10075	COG3250	beta-galactosidase activity
I6I29_RS10080	COG2211	Major facilitator Superfamily
I6I29_RS10085	COG0477	Major facilitator Superfamily
I6I29_RS10090	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6I29_RS10095	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I29_RS10105	COG2972	Histidine kinase
I6I29_RS10110	COG2207	Transcriptional regulator
I6I29_RS10110	COG4753	response regulator
I6I29_RS10135	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6I29_RS10135	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6I29_RS10145	COG1942	4-Oxalocrotonate Tautomerase
I6I29_RS10150	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I29_RS10170	COG1328	CTP reductase activity
I6I29_RS10180	COG3037	sugar-specific permease SgaT UlaA
I6I29_RS10190	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I29_RS10195	COG3711	transcriptional antiterminator
I6I29_RS10230	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6I29_RS10250	COG1869	D-ribose catabolic process
I6I29_RS10255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I29_RS10260	COG1609	Transcriptional regulator
I6I29_RS10280	COG1116	anion transmembrane transporter activity
I6I29_RS10290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6I29_RS10300	COG2814	Major facilitator Superfamily
I6I29_RS10310	COG0318	PFAM AMP-dependent synthetase and ligase
I6I29_RS10325	COG0183	Belongs to the thiolase family
I6I29_RS10330	COG0438	transferase activity, transferring glycosyl groups
I6I29_RS10350	COG1073	alpha beta
I6I29_RS10410	COG0579	oxidoreductase
I6I29_RS10435	COG1755	Isoprenylcysteine carboxyl methyltransferase
I6I29_RS10455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I29_RS10465	COG1136	(ABC) transporter
I6I29_RS10490	COG0436	Aminotransferase
I6I29_RS10500	COG0783	Belongs to the Dps family
I6I29_RS10510	COG0753	catalase activity
I6I29_RS10515	COG2318	DinB family
I6I29_RS10530	COG0076	glutamate decarboxylase activity
I6I29_RS10545	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6I29_RS10590	COG0156	8-amino-7-oxononanoate synthase activity
I6I29_RS10595	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6I29_RS10600	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6I29_RS10605	COG1620	l-lactate permease
I6I29_RS10620	COG1063	alcohol dehydrogenase
I6I29_RS10640	COG3314	Sporulation integral membrane protein YlbJ
I6I29_RS10660	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6I29_RS10670	COG3716	PTS system mannose fructose sorbose family IID component
I6I29_RS10675	COG3715	PTS system
I6I29_RS10680	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I29_RS10680	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I29_RS10695	COG1105	Belongs to the carbohydrate kinase PfkB family
I6I29_RS10700	COG2222	sugar isomerase
I6I29_RS10705	COG2188	Transcriptional regulator
I6I29_RS10710	COG0366	Alpha amylase catalytic
I6I29_RS10720	COG1131	(ABC) transporter
I6I29_RS10750	COG0346	lactoylglutathione lyase activity
I6I29_RS10760	COG0490	domain, Protein
I6I29_RS10765	COG0475	glutathione-regulated potassium exporter activity
I6I29_RS10770	COG3842	ATPase activity
I6I29_RS10780	COG1175	transmembrane transport
I6I29_RS10785	COG3833	ABC-type maltose transport systems, permease component
I6I29_RS10795	COG0366	Alpha amylase catalytic
I6I29_RS10805	COG0673	inositol 2-dehydrogenase activity
I6I29_RS10815	COG1609	Transcriptional regulator
I6I29_RS10840	COG0431	NADPH-dependent FMN reductase
I6I29_RS10865	COG0842	Transport permease protein
I6I29_RS10870	COG2203	Gaf domain
I6I29_RS10870	COG4585	Histidine kinase
I6I29_RS10875	COG2197	response regulator
I6I29_RS10890	COG2235	arginine
I6I29_RS10910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I29_RS10925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I29_RS10930	COG3177	Filamentation induced by cAMP protein fic
I6I29_RS10945	COG2130	NADP-dependent
I6I29_RS10950	COG0702	epimerase
I6I29_RS10965	COG0415	Belongs to the DNA photolyase family
I6I29_RS10975	COG2723	6-phospho-beta-galactosidase activity
I6I29_RS10980	COG2188	Transcriptional regulator
I6I29_RS10995	COG3655	Transcriptional regulator
I6I29_RS11010	COG2217	Heavy metal translocating P-type atpase
I6I29_RS11015	COG0531	amino acid
I6I29_RS11055	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6I29_RS11065	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6I29_RS11070	COG0514	ATP-dependent DNA helicase (RecQ)
I6I29_RS11150	COG0730	response to heat
I6I29_RS11155	COG1937	Protein conserved in bacteria
I6I29_RS11160	COG2210	Belongs to the sulfur carrier protein TusA family
I6I29_RS11170	COG1940	carbohydrate kinase activity
I6I29_RS11170	COG1846	Transcriptional regulator
I6I29_RS11195	COG2030	dehydratase
I6I29_RS11200	COG0584	glycerophosphoryl diester phosphodiesterase
I6I29_RS11230	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6I29_RS11240	COG4863	YycH protein
I6I29_RS11245	COG5002	protein histidine kinase activity
I6I29_RS11250	COG0745	RESPONSE REGULATOR receiver
I6I29_RS11270	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6I29_RS11275	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6I29_RS11280	COG0305	Participates in initiation and elongation during chromosome replication
I6I29_RS11285	COG0359	binds to the 23S rRNA
I6I29_RS11290	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I6I29_RS11295	COG4241	membrane
I6I29_RS11300	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I29_RS11310	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6I29_RS11320	COG2986	histidine ammonia-lyase
I6I29_RS11325	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6I29_RS11335	COG0187	DNA topoisomerase II activity
I6I29_RS11340	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I29_RS11345	COG2501	S4 domain
I6I29_RS11350	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6I29_RS11350	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I29_RS11355	COG0592	DNA-directed DNA polymerase activity
I6I29_RS11360	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I29_RS11370	COG0594	ribonuclease P activity
I6I29_RS11375	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6I29_RS11380	COG0445	tRNA wobble uridine modification
I6I29_RS11385	COG0357	Ribosomal RNA small subunit methyltransferase G
I6I29_RS11400	COG0400	carboxylic ester hydrolase activity
I6I29_RS11405	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I29_RS11410	COG0346	lactoylglutathione lyase activity
I6I29_RS11415	COG1846	Transcriptional regulator
I6I29_RS11420	COG2388	GCN5-related N-acetyl-transferase
I6I29_RS11430	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
I6I29_RS11435	COG0830	nickel cation binding
I6I29_RS11445	COG0829	nickel cation binding
I6I29_RS11455	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6I29_RS11455	COG0646	methionine synthase
I6I29_RS11460	COG0626	cystathionine gamma-synthase activity
I6I29_RS11465	COG0626	cystathionine gamma-synthase activity
I6I29_RS11470	COG1475	DNA binding
I6I29_RS11475	COG0668	transmembrane transport
I6I29_RS11480	COG4481	Protein conserved in bacteria
I6I29_RS11485	COG0012	GTP binding
I6I29_RS11515	COG0012	GTP binding
I6I29_RS11520	COG1131	(ABC) transporter
I6I29_RS11525	COG1668	transmembrane transport
I6I29_RS11535	COG0360	Binds together with S18 to 16S ribosomal RNA
I6I29_RS11545	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6I29_RS11555	COG0753	catalase activity
I6I29_RS11560	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6I29_RS11565	COG1464	Belongs to the NlpA lipoprotein family
I6I29_RS11570	COG2011	ABC-type metal ion transport system permease component
I6I29_RS11575	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I29_RS11585	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6I29_RS11600	COG0450	alkyl hydroperoxide reductase
I6I29_RS11605	COG0778	Nitroreductase
I6I29_RS11630	COG1823	symporter activity
I6I29_RS11635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6I29_RS11640	COG5183	chlorophyll binding
I6I29_RS11655	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I29_RS11660	COG2233	PERMEase
I6I29_RS11665	COG0517	IMP dehydrogenase activity
I6I29_RS11665	COG0516	GMP reductase activity
I6I29_RS11670	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I29_RS11670	COG0519	Catalyzes the synthesis of GMP from XMP
I6I29_RS11675	COG0582	viral genome integration into host DNA
I6I29_RS11700	COG3617	BRO family, N-terminal domain
I6I29_RS11740	COG1525	nuclease
I6I29_RS11760	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6I29_RS11785	COG0747	negative chemotaxis
I6I29_RS11790	COG0601	transmembrane transport
I6I29_RS11795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I29_RS11800	COG0444	Belongs to the ABC transporter superfamily
I6I29_RS11805	COG1124	(ABC) transporter
I6I29_RS11830	COG3682	Transcriptional regulator
I6I29_RS11850	COG2814	Major facilitator Superfamily
I6I29_RS11855	COG0730	response to heat
I6I29_RS11860	COG1937	Protein conserved in bacteria
I6I29_RS11865	COG2210	Belongs to the sulfur carrier protein TusA family
I6I29_RS11885	COG1263	PTS System
I6I29_RS11885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I29_RS11890	COG1486	melibiose metabolic process
I6I29_RS11900	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6I29_RS11930	COG0574	Belongs to the PEP-utilizing enzyme family
I6I29_RS11930	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I29_RS11935	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6I29_RS11950	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6I29_RS11955	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6I29_RS11965	COG2205	protein histidine kinase activity
I6I29_RS11970	COG0745	RESPONSE REGULATOR receiver
I6I29_RS11980	COG0733	neurotransmitter:sodium symporter activity
I6I29_RS11985	COG2272	Belongs to the type-B carboxylesterase lipase family
I6I29_RS11990	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I29_RS11995	COG0626	cystathionine gamma-synthase activity
I6I29_RS12040	COG1131	(ABC) transporter
I6I29_RS12050	COG0535	radical SAM domain protein
I6I29_RS12060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I29_RS12075	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6I29_RS12090	COG0583	DNA-binding transcription factor activity
I6I29_RS12095	COG0070	glutamate synthase
I6I29_RS12095	COG0069	glutamate synthase activity
I6I29_RS12095	COG0067	glutamate synthase
I6I29_RS12100	COG0493	'glutamate synthase
I6I29_RS12110	COG1263	PTS System
I6I29_RS12110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I29_RS12115	COG0366	Alpha amylase catalytic
I6I29_RS12120	COG2188	Transcriptional regulator
I6I29_RS12130	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6I29_RS12135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6I29_RS12140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6I29_RS12145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6I29_RS12170	COG1982	Orn Lys Arg decarboxylase major
I6I29_RS12175	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6I29_RS12180	COG3870	Protein conserved in bacteria
I6I29_RS12185	COG0470	DNA polymerase III
I6I29_RS12190	COG1774	PSP1 C-terminal conserved region
I6I29_RS12195	COG4467	Involved in initiation control of chromosome replication
I6I29_RS12200	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6I29_RS12205	COG2827	Endonuclease containing a URI domain
I6I29_RS12210	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6I29_RS12220	COG0084	hydrolase, TatD family'
I6I29_RS12225	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I6I29_RS12235	COG4466	Protein conserved in bacteria
I6I29_RS12240	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6I29_RS12245	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I29_RS12250	COG0251	oxidation-reduction process
I6I29_RS12255	COG2088	sporulation resulting in formation of a cellular spore
I6I29_RS12260	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I29_RS12265	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6I29_RS12275	COG0193	aminoacyl-tRNA hydrolase activity
I6I29_RS12280	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6I29_RS12285	COG2244	polysaccharide biosynthetic process
I6I29_RS12290	COG3956	TIGRFAM MazG family protein
I6I29_RS12295	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6I29_RS12305	COG1098	S1 RNA binding domain
I6I29_RS12320	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I29_RS12325	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6I29_RS12335	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6I29_RS12345	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6I29_RS12350	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I29_RS12440	COG1289	transmembrane transporter activity
I6I29_RS12445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I29_RS12450	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I6I29_RS12455	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I6I29_RS12465	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6I29_RS12475	COG3880	PFAM UvrB UvrC protein
I6I29_RS12480	COG3869	Catalyzes the specific phosphorylation of arginine residues in
I6I29_RS12485	COG0542	response to heat
I6I29_RS12520	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6I29_RS12525	COG4956	integral membrane protein (PIN domain superfamily)
I6I29_RS12530	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6I29_RS12540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I29_RS12545	COG1045	serine acetyltransferase
I6I29_RS12550	COG0215	cysteine-tRNA ligase activity
I6I29_RS12555	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I6I29_RS12575	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6I29_RS12580	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6I29_RS12585	COG0250	Participates in transcription elongation, termination and antitermination
I6I29_RS12590	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6I29_RS12595	COG0081	regulation of translation
I6I29_RS12600	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6I29_RS12610	COG2813	Specifically methylates the guanine in position
I6I29_RS12615	COG0085	RNA polymerase activity
I6I29_RS12620	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6I29_RS12630	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6I29_RS12635	COG0049	tRNA binding
I6I29_RS12640	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6I29_RS12645	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I29_RS12650	COG3527	Alpha-acetolactate decarboxylase
I6I29_RS12655	COG1473	amidohydrolase
I6I29_RS12665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I29_RS12705	COG0546	phosphoglycolate phosphatase activity
I6I29_RS12710	COG1428	Deoxynucleoside kinase
I6I29_RS12715	COG1428	Deoxynucleoside kinase
I6I29_RS12725	COG0561	phosphatase activity
I6I29_RS12740	COG1136	(ABC) transporter
I6I29_RS12740	COG0577	efflux transmembrane transporter activity
I6I29_RS12745	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6I29_RS12785	COG1469	GTP cyclohydrolase I activity
I6I29_RS12790	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6I29_RS12805	COG1263	PTS System
I6I29_RS12805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I29_RS12805	COG2190	(PTS) system
I6I29_RS12820	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I6I29_RS12830	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I29_RS12840	COG2814	Major facilitator Superfamily
I6I29_RS12850	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6I29_RS12855	COG0588	phosphoglycerate mutase activity
I6I29_RS12860	COG0318	PFAM AMP-dependent synthetase and ligase
I6I29_RS12865	COG0183	Belongs to the thiolase family
I6I29_RS12895	COG2363	Small membrane protein
I6I29_RS12910	COG2311	Membrane
I6I29_RS12920	COG1566	PFAM secretion protein HlyD family protein
I6I29_RS12925	COG2814	Major facilitator Superfamily
I6I29_RS12935	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6I29_RS12940	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I29_RS12960	COG0095	Lipoate-protein ligase
I6I29_RS12990	COG0471	metal ion transport
I6I29_RS13055	COG4844	belongs to the
I6I29_RS13065	COG1078	dGTPase activity
I6I29_RS13080	COG0018	arginyl-trna synthetase
I6I29_RS13085	COG0805	protein transport
I6I29_RS13090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I29_RS13095	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I29_RS13100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I29_RS13105	COG0546	phosphoglycolate phosphatase activity
I6I29_RS13155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I29_RS13155	COG2111	Na H antiporter
I6I29_RS13160	COG2111	Na H antiporter
I6I29_RS13165	COG1006	Multisubunit Na H antiporter MnhC subunit
I6I29_RS13175	COG1863	multisubunit Na H antiporter MnhE subunit
I6I29_RS13180	COG2212	antiporter activity
I6I29_RS13185	COG1320	monovalent cation:proton antiporter activity
I6I29_RS13190	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6I29_RS13195	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I29_RS13200	COG1121	(ABC) transporter
I6I29_RS13210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I29_RS13215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I29_RS13220	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I29_RS13230	COG2423	ornithine cyclodeaminase activity
I6I29_RS13235	COG4264	IucA IucC family
I6I29_RS13240	COG2814	Major facilitator Superfamily
I6I29_RS13245	COG4264	IucA IucC family
I6I29_RS13250	COG4264	IucA IucC family
I6I29_RS13260	COG0019	diaminopimelate decarboxylase activity
I6I29_RS13265	COG1475	DNA binding
I6I29_RS13275	COG0110	maltose O-acetyltransferase activity
I6I29_RS13280	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I6I29_RS13290	COG1682	transport, permease protein
I6I29_RS13295	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6I29_RS13300	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6I29_RS13320	COG1686	Belongs to the peptidase S11 family
I6I29_RS13325	COG1132	(ABC) transporter
I6I29_RS13345	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6I29_RS13350	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6I29_RS13355	COG1120	ATPase activity
I6I29_RS13360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I29_RS13365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I29_RS13375	COG0477	Major facilitator Superfamily
I6I29_RS13380	COG3949	Membrane
I6I29_RS13390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I29_RS13395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I29_RS13400	COG0745	RESPONSE REGULATOR receiver
I6I29_RS13410	COG1136	(ABC) transporter
I6I29_RS13415	COG0577	efflux transmembrane transporter activity
I6I29_RS13420	COG1392	Phosphate transport regulator
I6I29_RS13425	COG0306	phosphate transporter
I6I29_RS13430	COG1388	LysM domain
I6I29_RS13430	COG3942	CHAP domain
I6I29_RS13440	COG0352	thiamine-phosphate diphosphorylase activity
I6I29_RS13450	COG2022	thiamine diphosphate biosynthetic process
I6I29_RS13455	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6I29_RS13460	COG0217	transcriptional regulatory protein
I6I29_RS13475	COG0583	DNA-binding transcription factor activity
I6I29_RS13480	COG2814	Major facilitator Superfamily
I6I29_RS13485	COG2839	Protein conserved in bacteria
I6I29_RS13515	COG1611	Belongs to the LOG family
I6I29_RS13520	COG1671	Belongs to the UPF0178 family
I6I29_RS13530	COG1968	undecaprenyl-diphosphatase activity
I6I29_RS13535	COG4988	ABC transporter
I6I29_RS13540	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6I29_RS13550	COG0523	cobalamin synthesis protein
I6I29_RS13555	COG4989	oxidoreductase activity
I6I29_RS13570	COG0039	L-malate dehydrogenase activity
I6I29_RS13590	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6I29_RS13595	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6I29_RS13610	COG1349	DNA-binding transcription factor activity
I6I29_RS13615	COG1105	Belongs to the carbohydrate kinase PfkB family
I6I29_RS13620	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I29_RS13620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I29_RS13620	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I29_RS13625	COG1253	flavin adenine dinucleotide binding
I6I29_RS13630	COG0463	Glycosyl transferase, family 2
I6I29_RS13645	COG0602	queuosine metabolic process
I6I29_RS13650	COG0720	synthase
I6I29_RS13660	COG0512	Glutamine amidotransferase of anthranilate synthase
I6I29_RS13680	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6I29_RS13690	COG1368	sulfuric ester hydrolase activity
I6I29_RS13695	COG0463	Glycosyl transferase, family 2
I6I29_RS13710	COG2274	protein secretion by the type I secretion system
I6I29_RS13720	COG0488	(ABC) transporter
I6I29_RS13725	COG0514	ATP-dependent DNA helicase (RecQ)
I6I29_RS13730	COG0517	IMP dehydrogenase activity
I6I29_RS13730	COG1125	glycine betaine transport
I6I29_RS13735	COG1174	glycine betaine transport
I6I29_RS13740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I29_RS13755	COG3104	oligopeptide transport
I6I29_RS13760	COG3104	oligopeptide transport
I6I29_RS13795	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I29_RS13800	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I29_RS13810	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6I29_RS13825	COG3118	belongs to the thioredoxin family
I6I29_RS13830	COG1929	Belongs to the glycerate kinase type-1 family
I6I29_RS13835	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6I29_RS13855	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I29_RS13860	COG1739	Uncharacterized protein family UPF0029
I6I29_RS13870	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I6I29_RS13885	COG0653	protein targeting