locus-tag	class	description
D8L98_RS00010	COG1481	regulation of sporulation
D8L98_RS00015	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D8L98_RS00020	COG1660	Displays ATPase and GTPase activities
D8L98_RS00035	COG0110	maltose O-acetyltransferase activity
D8L98_RS00040	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D8L98_RS00045	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
D8L98_RS00080	COG0653	protein targeting
D8L98_RS00095	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
D8L98_RS00105	COG1739	Uncharacterized protein family UPF0029
D8L98_RS00110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D8L98_RS00130	COG2195	Cleaves the N-terminal amino acid of tripeptides
D8L98_RS00135	COG1929	Belongs to the glycerate kinase type-1 family
D8L98_RS00140	COG3118	belongs to the thioredoxin family
D8L98_RS00155	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D8L98_RS00165	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D8L98_RS00170	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D8L98_RS00205	COG3104	oligopeptide transport
D8L98_RS00210	COG3104	oligopeptide transport
D8L98_RS00225	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D8L98_RS00230	COG1174	glycine betaine transport
D8L98_RS00235	COG0517	IMP dehydrogenase activity
D8L98_RS00235	COG1125	glycine betaine transport
D8L98_RS00240	COG0514	ATP-dependent DNA helicase (RecQ)
D8L98_RS00245	COG0488	(ABC) transporter
D8L98_RS00270	COG0463	Glycosyl transferase, family 2
D8L98_RS00285	COG1368	sulfuric ester hydrolase activity
D8L98_RS00295	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D8L98_RS00315	COG0512	Glutamine amidotransferase of anthranilate synthase
D8L98_RS00325	COG0720	synthase
D8L98_RS00330	COG0602	queuosine metabolic process
D8L98_RS00345	COG0463	Glycosyl transferase, family 2
D8L98_RS00350	COG1253	flavin adenine dinucleotide binding
D8L98_RS00355	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D8L98_RS00355	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D8L98_RS00355	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D8L98_RS00360	COG1105	Belongs to the carbohydrate kinase PfkB family
D8L98_RS00365	COG1349	DNA-binding transcription factor activity
D8L98_RS00385	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D8L98_RS00390	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D8L98_RS00415	COG0039	L-malate dehydrogenase activity
D8L98_RS00430	COG4989	oxidoreductase activity
D8L98_RS00435	COG0523	cobalamin synthesis protein
D8L98_RS00450	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D8L98_RS00455	COG4988	ABC transporter
D8L98_RS00460	COG1968	undecaprenyl-diphosphatase activity
D8L98_RS00470	COG1671	Belongs to the UPF0178 family
D8L98_RS00475	COG1611	Belongs to the LOG family
D8L98_RS00505	COG2839	Protein conserved in bacteria
D8L98_RS00510	COG2814	Major facilitator Superfamily
D8L98_RS00515	COG0583	DNA-binding transcription factor activity
D8L98_RS00530	COG0217	transcriptional regulatory protein
D8L98_RS00535	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D8L98_RS00540	COG2022	thiamine diphosphate biosynthetic process
D8L98_RS00550	COG0352	thiamine-phosphate diphosphorylase activity
D8L98_RS00560	COG1388	LysM domain
D8L98_RS00560	COG3942	CHAP domain
D8L98_RS00565	COG0306	phosphate transporter
D8L98_RS00570	COG1392	Phosphate transport regulator
D8L98_RS00575	COG0577	efflux transmembrane transporter activity
D8L98_RS00580	COG1136	(ABC) transporter
D8L98_RS00590	COG0745	RESPONSE REGULATOR receiver
D8L98_RS00595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D8L98_RS00600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D8L98_RS00610	COG3949	Membrane
D8L98_RS00615	COG0477	Major facilitator Superfamily
D8L98_RS00625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D8L98_RS00630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D8L98_RS00635	COG1120	ATPase activity
D8L98_RS00640	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D8L98_RS00645	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D8L98_RS00665	COG1132	(ABC) transporter
D8L98_RS00670	COG1686	Belongs to the peptidase S11 family
D8L98_RS00690	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D8L98_RS00695	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D8L98_RS00700	COG1682	transport, permease protein
D8L98_RS00710	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D8L98_RS00715	COG0110	maltose O-acetyltransferase activity
D8L98_RS00725	COG1475	DNA binding
D8L98_RS00730	COG0019	diaminopimelate decarboxylase activity
D8L98_RS00740	COG4264	IucA IucC family
D8L98_RS00745	COG4264	IucA IucC family
D8L98_RS00750	COG2814	Major facilitator Superfamily
D8L98_RS00755	COG4264	IucA IucC family
D8L98_RS00760	COG2423	ornithine cyclodeaminase activity
D8L98_RS00770	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D8L98_RS00775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D8L98_RS00780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D8L98_RS00790	COG1121	(ABC) transporter
D8L98_RS00795	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D8L98_RS00800	COG0803	Belongs to the bacterial solute-binding protein 9 family
D8L98_RS00810	COG1320	monovalent cation:proton antiporter activity
D8L98_RS00815	COG2212	antiporter activity
D8L98_RS00820	COG1863	multisubunit Na H antiporter MnhE subunit
D8L98_RS00830	COG1006	Multisubunit Na H antiporter MnhC subunit
D8L98_RS00835	COG2111	Na H antiporter
D8L98_RS00840	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D8L98_RS00840	COG2111	Na H antiporter
D8L98_RS00890	COG0546	phosphoglycolate phosphatase activity
D8L98_RS00895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D8L98_RS00900	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D8L98_RS00905	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D8L98_RS00915	COG0018	arginyl-trna synthetase
D8L98_RS00930	COG1078	dGTPase activity
D8L98_RS00940	COG4844	belongs to the
D8L98_RS01005	COG0471	metal ion transport
D8L98_RS01040	COG0095	Lipoate-protein ligase
D8L98_RS01065	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D8L98_RS01070	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D8L98_RS01080	COG2814	Major facilitator Superfamily
D8L98_RS01085	COG1566	PFAM secretion protein HlyD family protein
D8L98_RS01095	COG2311	Membrane
D8L98_RS01110	COG2363	Small membrane protein
D8L98_RS01140	COG0183	Belongs to the thiolase family
D8L98_RS01145	COG0318	PFAM AMP-dependent synthetase and ligase
D8L98_RS01150	COG0588	phosphoglycerate mutase activity
D8L98_RS01155	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D8L98_RS01165	COG2814	Major facilitator Superfamily
D8L98_RS01180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D8L98_RS01190	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
D8L98_RS01205	COG1263	PTS System
D8L98_RS01205	COG2190	(PTS) system
D8L98_RS01205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D8L98_RS01220	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D8L98_RS01225	COG1469	GTP cyclohydrolase I activity
D8L98_RS01270	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D8L98_RS01275	COG0577	efflux transmembrane transporter activity
D8L98_RS01275	COG1136	(ABC) transporter
D8L98_RS01290	COG0561	phosphatase activity
D8L98_RS01300	COG1428	Deoxynucleoside kinase
D8L98_RS01305	COG1428	Deoxynucleoside kinase
D8L98_RS01310	COG0546	phosphoglycolate phosphatase activity
D8L98_RS01350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D8L98_RS01360	COG1473	amidohydrolase
D8L98_RS01365	COG3527	Alpha-acetolactate decarboxylase
D8L98_RS01370	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D8L98_RS01375	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D8L98_RS01380	COG0049	tRNA binding
D8L98_RS01385	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D8L98_RS01395	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D8L98_RS01400	COG0085	RNA polymerase activity
D8L98_RS01405	COG2813	Specifically methylates the guanine in position
D8L98_RS01415	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D8L98_RS01420	COG0081	regulation of translation
D8L98_RS01425	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D8L98_RS01430	COG0250	Participates in transcription elongation, termination and antitermination
D8L98_RS01435	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D8L98_RS01440	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D8L98_RS01460	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
D8L98_RS01465	COG0215	cysteine-tRNA ligase activity
D8L98_RS01470	COG1045	serine acetyltransferase
D8L98_RS01475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D8L98_RS01485	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D8L98_RS01490	COG4956	integral membrane protein (PIN domain superfamily)
D8L98_RS01495	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D8L98_RS01530	COG0542	response to heat
D8L98_RS01535	COG3869	Catalyzes the specific phosphorylation of arginine residues in
D8L98_RS01540	COG3880	PFAM UvrB UvrC protein
D8L98_RS01550	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D8L98_RS01560	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
D8L98_RS01565	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
D8L98_RS01570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D8L98_RS01575	COG1289	transmembrane transporter activity
D8L98_RS01665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D8L98_RS01670	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D8L98_RS01680	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D8L98_RS01690	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D8L98_RS01695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D8L98_RS01710	COG1098	S1 RNA binding domain
D8L98_RS01720	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D8L98_RS01725	COG3956	TIGRFAM MazG family protein
D8L98_RS01730	COG2244	polysaccharide biosynthetic process
D8L98_RS01735	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D8L98_RS01740	COG0193	aminoacyl-tRNA hydrolase activity
D8L98_RS01750	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D8L98_RS01755	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D8L98_RS01760	COG2088	sporulation resulting in formation of a cellular spore
D8L98_RS01765	COG0251	oxidation-reduction process
D8L98_RS01770	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D8L98_RS01775	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D8L98_RS01780	COG4466	Protein conserved in bacteria
D8L98_RS01790	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
D8L98_RS01795	COG0084	hydrolase, TatD family'
D8L98_RS01805	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D8L98_RS01810	COG2827	Endonuclease containing a URI domain
D8L98_RS01815	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D8L98_RS01820	COG4467	Involved in initiation control of chromosome replication
D8L98_RS01825	COG1774	PSP1 C-terminal conserved region
D8L98_RS01830	COG0470	DNA polymerase III
D8L98_RS01835	COG3870	Protein conserved in bacteria
D8L98_RS01840	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D8L98_RS01845	COG1982	Orn Lys Arg decarboxylase major
D8L98_RS01870	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D8L98_RS01875	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D8L98_RS01880	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D8L98_RS01885	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D8L98_RS01895	COG2188	Transcriptional regulator
D8L98_RS01900	COG0366	Alpha amylase catalytic
D8L98_RS01905	COG1263	PTS System
D8L98_RS01905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D8L98_RS01915	COG0493	'glutamate synthase
D8L98_RS01920	COG0067	glutamate synthase
D8L98_RS01920	COG0070	glutamate synthase
D8L98_RS01920	COG0069	glutamate synthase activity
D8L98_RS01925	COG0583	DNA-binding transcription factor activity
D8L98_RS01940	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D8L98_RS01955	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D8L98_RS01965	COG0535	radical SAM domain protein
D8L98_RS01975	COG1131	(ABC) transporter
D8L98_RS02020	COG0626	cystathionine gamma-synthase activity
D8L98_RS02025	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D8L98_RS02030	COG2272	Belongs to the type-B carboxylesterase lipase family
D8L98_RS02035	COG0733	neurotransmitter:sodium symporter activity
D8L98_RS02045	COG0745	RESPONSE REGULATOR receiver
D8L98_RS02060	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D8L98_RS02065	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
D8L98_RS02080	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D8L98_RS02085	COG0574	Belongs to the PEP-utilizing enzyme family
D8L98_RS02085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D8L98_RS02115	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D8L98_RS02125	COG1486	melibiose metabolic process
D8L98_RS02130	COG1263	PTS System
D8L98_RS02130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D8L98_RS02150	COG2210	Belongs to the sulfur carrier protein TusA family
D8L98_RS02155	COG1937	Protein conserved in bacteria
D8L98_RS02160	COG0730	response to heat
D8L98_RS02165	COG2814	Major facilitator Superfamily
D8L98_RS02190	COG3682	Transcriptional regulator
D8L98_RS02215	COG1124	(ABC) transporter
D8L98_RS02220	COG0444	Belongs to the ABC transporter superfamily
D8L98_RS02225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D8L98_RS02230	COG0601	transmembrane transport
D8L98_RS02235	COG0747	negative chemotaxis
D8L98_RS02260	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D8L98_RS02280	COG1525	nuclease
D8L98_RS02320	COG3617	BRO family, N-terminal domain
D8L98_RS02340	COG0582	viral genome integration into host DNA
D8L98_RS02345	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D8L98_RS02345	COG0519	Catalyzes the synthesis of GMP from XMP
D8L98_RS02350	COG0516	GMP reductase activity
D8L98_RS02350	COG0517	IMP dehydrogenase activity
D8L98_RS02355	COG2233	PERMEase
D8L98_RS02360	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D8L98_RS02375	COG5183	chlorophyll binding
D8L98_RS02380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D8L98_RS02385	COG1823	symporter activity
D8L98_RS02410	COG0778	Nitroreductase
D8L98_RS02415	COG0450	alkyl hydroperoxide reductase
D8L98_RS02430	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D8L98_RS02440	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D8L98_RS02445	COG2011	ABC-type metal ion transport system permease component
D8L98_RS02450	COG1464	Belongs to the NlpA lipoprotein family
D8L98_RS02455	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D8L98_RS02460	COG0753	catalase activity
D8L98_RS02470	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D8L98_RS02480	COG0360	Binds together with S18 to 16S ribosomal RNA
D8L98_RS02490	COG1668	transmembrane transport
D8L98_RS02495	COG1131	(ABC) transporter
D8L98_RS02500	COG0012	GTP binding
D8L98_RS02530	COG0012	GTP binding
D8L98_RS02535	COG4481	Protein conserved in bacteria
D8L98_RS02540	COG0668	transmembrane transport
D8L98_RS02545	COG1475	DNA binding
D8L98_RS02550	COG0626	cystathionine gamma-synthase activity
D8L98_RS02555	COG0626	cystathionine gamma-synthase activity
D8L98_RS02560	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D8L98_RS02560	COG0646	methionine synthase
D8L98_RS02570	COG0829	nickel cation binding
D8L98_RS02580	COG0830	nickel cation binding
D8L98_RS02585	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
D8L98_RS02595	COG2388	GCN5-related N-acetyl-transferase
D8L98_RS02600	COG1846	Transcriptional regulator
D8L98_RS02605	COG0346	lactoylglutathione lyase activity
D8L98_RS02610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D8L98_RS02615	COG0400	carboxylic ester hydrolase activity
D8L98_RS02630	COG0357	Ribosomal RNA small subunit methyltransferase G
D8L98_RS02635	COG0445	tRNA wobble uridine modification
D8L98_RS02640	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D8L98_RS02645	COG0594	ribonuclease P activity
D8L98_RS02655	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D8L98_RS02660	COG0592	DNA-directed DNA polymerase activity
D8L98_RS02665	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D8L98_RS02665	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D8L98_RS02670	COG2501	S4 domain
D8L98_RS02675	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D8L98_RS02680	COG0187	DNA topoisomerase II activity
D8L98_RS02690	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D8L98_RS02695	COG2986	histidine ammonia-lyase
D8L98_RS02705	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D8L98_RS02715	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D8L98_RS02720	COG4241	membrane
D8L98_RS02725	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
D8L98_RS02730	COG0359	binds to the 23S rRNA
D8L98_RS02740	COG0305	Participates in initiation and elongation during chromosome replication
D8L98_RS02745	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D8L98_RS02750	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D8L98_RS02770	COG0745	RESPONSE REGULATOR receiver
D8L98_RS02775	COG5002	protein histidine kinase activity
D8L98_RS02780	COG4863	YycH protein
D8L98_RS02790	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D8L98_RS02815	COG3425	synthase
D8L98_RS02825	COG0584	glycerophosphoryl diester phosphodiesterase
D8L98_RS02830	COG2030	dehydratase
D8L98_RS02855	COG1846	Transcriptional regulator
D8L98_RS02855	COG1940	carbohydrate kinase activity
D8L98_RS02865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D8L98_RS02870	COG2210	Belongs to the sulfur carrier protein TusA family
D8L98_RS02875	COG1937	Protein conserved in bacteria
D8L98_RS02880	COG0730	response to heat
D8L98_RS02965	COG0514	ATP-dependent DNA helicase (RecQ)
D8L98_RS02970	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
D8L98_RS02980	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D8L98_RS03020	COG0531	amino acid
D8L98_RS03025	COG2217	Heavy metal translocating P-type atpase
D8L98_RS03040	COG3655	Transcriptional regulator
D8L98_RS03055	COG2188	Transcriptional regulator
D8L98_RS03060	COG2723	6-phospho-beta-galactosidase activity
D8L98_RS03070	COG0415	Belongs to the DNA photolyase family
D8L98_RS03085	COG0702	epimerase
D8L98_RS03090	COG2130	NADP-dependent
D8L98_RS03105	COG3177	Filamentation induced by cAMP protein fic
D8L98_RS03110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D8L98_RS03125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D8L98_RS03145	COG2235	arginine
D8L98_RS03160	COG2197	response regulator
D8L98_RS03165	COG4585	Histidine kinase
D8L98_RS03165	COG2203	Gaf domain
D8L98_RS03170	COG0842	Transport permease protein
D8L98_RS03195	COG0431	NADPH-dependent FMN reductase
D8L98_RS03220	COG1609	Transcriptional regulator
D8L98_RS03230	COG0673	inositol 2-dehydrogenase activity
D8L98_RS03240	COG0366	Alpha amylase catalytic
D8L98_RS03250	COG3833	ABC-type maltose transport systems, permease component
D8L98_RS03255	COG1175	transmembrane transport
D8L98_RS03265	COG3842	ATPase activity
D8L98_RS03270	COG0475	glutathione-regulated potassium exporter activity
D8L98_RS03275	COG0490	domain, Protein
D8L98_RS03285	COG0346	lactoylglutathione lyase activity
D8L98_RS03320	COG1131	(ABC) transporter
D8L98_RS03335	COG0366	Alpha amylase catalytic
D8L98_RS03340	COG2188	Transcriptional regulator
D8L98_RS03345	COG2222	sugar isomerase
D8L98_RS03350	COG1105	Belongs to the carbohydrate kinase PfkB family
D8L98_RS03365	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D8L98_RS03365	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D8L98_RS03370	COG3715	PTS system
D8L98_RS03375	COG3716	PTS system mannose fructose sorbose family IID component
D8L98_RS03385	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D8L98_RS03405	COG3314	Sporulation integral membrane protein YlbJ
D8L98_RS03425	COG1063	alcohol dehydrogenase
D8L98_RS03440	COG1620	l-lactate permease
D8L98_RS03445	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D8L98_RS03450	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D8L98_RS03455	COG0156	8-amino-7-oxononanoate synthase activity
D8L98_RS03500	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D8L98_RS03515	COG0076	glutamate decarboxylase activity
D8L98_RS03530	COG2318	DinB family
D8L98_RS03535	COG0753	catalase activity
D8L98_RS03545	COG0783	Belongs to the Dps family
D8L98_RS03555	COG0436	Aminotransferase
D8L98_RS03580	COG1136	(ABC) transporter
D8L98_RS03590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D8L98_RS03610	COG1755	Isoprenylcysteine carboxyl methyltransferase
D8L98_RS03635	COG0579	oxidoreductase
D8L98_RS03655	COG1073	alpha beta
D8L98_RS03675	COG0438	transferase activity, transferring glycosyl groups
D8L98_RS03680	COG0183	Belongs to the thiolase family
D8L98_RS03695	COG0318	PFAM AMP-dependent synthetase and ligase
D8L98_RS03705	COG2814	Major facilitator Superfamily
D8L98_RS03715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D8L98_RS03725	COG1116	anion transmembrane transporter activity
D8L98_RS03745	COG1609	Transcriptional regulator
D8L98_RS03750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D8L98_RS03755	COG1869	D-ribose catabolic process
D8L98_RS03770	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D8L98_RS03805	COG3711	transcriptional antiterminator
D8L98_RS03810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D8L98_RS03820	COG3037	sugar-specific permease SgaT UlaA
D8L98_RS03830	COG1328	CTP reductase activity
D8L98_RS03850	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D8L98_RS03855	COG1942	4-Oxalocrotonate Tautomerase
D8L98_RS03865	COG3443	Belongs to the bacterial solute-binding protein 9 family
D8L98_RS03865	COG0803	Belongs to the bacterial solute-binding protein 9 family
D8L98_RS03890	COG4753	response regulator
D8L98_RS03890	COG2207	Transcriptional regulator
D8L98_RS03895	COG2972	Histidine kinase
D8L98_RS03905	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D8L98_RS03910	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D8L98_RS03915	COG0477	Major facilitator Superfamily
D8L98_RS03920	COG2211	Major facilitator Superfamily
D8L98_RS03925	COG3250	beta-galactosidase activity
D8L98_RS03930	COG1957	nucleoside hydrolase
D8L98_RS03975	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D8L98_RS03980	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
D8L98_RS03985	COG2807	transmembrane transport
D8L98_RS03990	COG1396	sequence-specific DNA binding
D8L98_RS04005	COG1785	Belongs to the alkaline phosphatase family
D8L98_RS04010	COG0494	nUDIX hydrolase
D8L98_RS04015	COG0556	nucleotide-excision repair
D8L98_RS04030	COG1510	regulation of RNA biosynthetic process
D8L98_RS04035	COG1012	belongs to the aldehyde dehydrogenase family
D8L98_RS04040	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
D8L98_RS04045	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D8L98_RS04055	COG0156	8-amino-7-oxononanoate synthase activity
D8L98_RS04070	COG0107	imidazoleglycerol-phosphate synthase activity
D8L98_RS04075	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D8L98_RS04090	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D8L98_RS04095	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D8L98_RS04100	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D8L98_RS04105	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D8L98_RS04145	COG2376	Dihydroxyacetone kinase
D8L98_RS04150	COG1461	Dihydroxyacetone kinase
D8L98_RS04155	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
D8L98_RS04160	COG2824	Alkylphosphonate utilization operon protein PhnA
D8L98_RS04165	COG1012	belongs to the aldehyde dehydrogenase family
D8L98_RS04180	COG0596	Alpha beta hydrolase
D8L98_RS04185	COG0789	Transcriptional regulator
D8L98_RS04190	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D8L98_RS04190	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D8L98_RS04190	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D8L98_RS04200	COG1705	Flagellar rod assembly protein muramidase FlgJ
D8L98_RS04200	COG3942	CHAP domain
D8L98_RS04210	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D8L98_RS04215	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D8L98_RS04220	COG0747	negative chemotaxis
D8L98_RS04245	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D8L98_RS04245	COG0463	Glycosyl transferase, family 2
D8L98_RS04260	COG0778	Nitroreductase
D8L98_RS04265	COG3001	Fructosamine kinase
D8L98_RS04290	COG1136	(ABC) transporter
D8L98_RS04295	COG0577	efflux transmembrane transporter activity
D8L98_RS04305	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
D8L98_RS04315	COG4413	Urea transporter
D8L98_RS04325	COG0832	Belongs to the urease beta subunit family
D8L98_RS04330	COG0804	urea catabolic process
D8L98_RS04335	COG0717	Belongs to the dCTP deaminase family
D8L98_RS04340	COG0523	cobalamin synthesis protein
D8L98_RS04350	COG1141	Ferredoxin
D8L98_RS04380	COG0583	DNA-binding transcription factor activity
D8L98_RS04390	COG1346	cytolysis
D8L98_RS04405	COG1846	Transcriptional regulator
D8L98_RS04410	COG0778	Nitroreductase
D8L98_RS04415	COG2357	RelA SpoT domain protein
D8L98_RS04455	COG1028	Short-chain dehydrogenase reductase Sdr
D8L98_RS04470	COG3835	regulator
D8L98_RS04475	COG2855	membrane
D8L98_RS04480	COG3961	Belongs to the TPP enzyme family
D8L98_RS04485	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D8L98_RS04490	COG0512	Glutamine amidotransferase of anthranilate synthase
D8L98_RS04500	COG0134	indole-3-glycerol-phosphate synthase activity
D8L98_RS04510	COG0133	tryptophan synthase activity
D8L98_RS04515	COG0159	tryptophan synthase activity
D8L98_RS04535	COG0277	FAD linked oxidase domain protein
D8L98_RS04540	COG0247	lactate metabolic process
D8L98_RS04545	COG1132	(ABC) transporter
D8L98_RS04550	COG1132	(ABC) transporter
D8L98_RS04555	COG0789	Transcriptional regulator
D8L98_RS04565	COG3871	stress protein (general stress protein 26)
D8L98_RS04570	COG1115	amino acid carrier protein
D8L98_RS04575	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
D8L98_RS04580	COG2814	Major facilitator Superfamily
D8L98_RS04585	COG2271	Major facilitator Superfamily
D8L98_RS04590	COG3764	Sortase (surface protein transpeptidase)
D8L98_RS04595	COG1929	Belongs to the glycerate kinase type-1 family
D8L98_RS04605	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
D8L98_RS04625	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D8L98_RS04630	COG0702	epimerase
D8L98_RS04635	COG4166	transmembrane transport
D8L98_RS04640	COG0444	Belongs to the ABC transporter superfamily
D8L98_RS04645	COG4608	Belongs to the ABC transporter superfamily
D8L98_RS04650	COG0601	transmembrane transport
D8L98_RS04655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D8L98_RS04660	COG4166	transmembrane transport
D8L98_RS04665	COG0444	Belongs to the ABC transporter superfamily
D8L98_RS04670	COG4608	Belongs to the ABC transporter superfamily
D8L98_RS04675	COG0601	transmembrane transport
D8L98_RS04680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D8L98_RS04690	COG1760	l-serine dehydratase
D8L98_RS04695	COG1760	l-serine dehydratase
D8L98_RS04750	COG0471	metal ion transport
D8L98_RS04755	COG2116	formate transmembrane transporter activity
D8L98_RS04760	COG0454	-acetyltransferase
D8L98_RS04770	COG1648	precorrin-2 dehydrogenase activity
D8L98_RS04770	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D8L98_RS04775	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D8L98_RS04780	COG2146	nitrite reductase [NAD(P)H] activity
D8L98_RS04785	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D8L98_RS04785	COG1648	precorrin-2 dehydrogenase activity
D8L98_RS04790	COG0737	Belongs to the 5'-nucleotidase family
D8L98_RS04800	COG0018	arginyl-trna synthetase
D8L98_RS04815	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
D8L98_RS04820	COG1140	nitrate reductase beta subunit
D8L98_RS04830	COG2181	nitrate reductase activity
D8L98_RS04840	COG4585	Histidine kinase
D8L98_RS04845	COG2197	response regulator
D8L98_RS04855	COG2223	nitrite transmembrane transporter activity
D8L98_RS04860	COG3344	reverse transcriptase
D8L98_RS04865	COG4187	Peptidase family M20/M25/M40
D8L98_RS04875	COG0039	L-malate dehydrogenase activity
D8L98_RS04880	COG1363	Peptidase, m42
D8L98_RS04885	COG0697	spore germination
D8L98_RS04895	COG2807	transmembrane transport
D8L98_RS04905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D8L98_RS04905	COG1263	PTS System
D8L98_RS04920	COG1283	sodium-dependent phosphate transmembrane transporter activity
D8L98_RS04940	COG0492	ferredoxin-NADP+ reductase activity
D8L98_RS04945	COG2814	Major facilitator Superfamily
D8L98_RS04950	COG0604	alcohol dehydrogenase
D8L98_RS04965	COG1620	l-lactate permease
D8L98_RS04970	COG0438	transferase activity, transferring glycosyl groups
D8L98_RS04975	COG0579	oxidoreductase
D8L98_RS04990	COG0577	efflux transmembrane transporter activity
D8L98_RS05020	COG3344	reverse transcriptase
D8L98_RS05030	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D8L98_RS05040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D8L98_RS05060	COG1304	FMN binding
D8L98_RS05065	COG0523	cobalamin synthesis protein
D8L98_RS05070	COG0786	glutamate:sodium symporter activity
D8L98_RS05075	COG2207	Transcriptional regulator
D8L98_RS05100	COG1757	Na H antiporter
D8L98_RS05105	COG2094	Belongs to the DNA glycosylase MPG family
D8L98_RS05110	COG3152	Membrane
D8L98_RS05115	COG4152	abc transporter atp-binding protein
D8L98_RS05120	COG1668	transmembrane transport
D8L98_RS05125	COG1742	UPF0060 membrane protein
D8L98_RS05130	COG2017	converts alpha-aldose to the beta-anomer
D8L98_RS05135	COG2258	MOSC domain
D8L98_RS05140	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D8L98_RS05150	COG1266	CAAX protease self-immunity
D8L98_RS05155	COG0583	DNA-binding transcription factor activity
D8L98_RS05160	COG3314	Sporulation integral membrane protein YlbJ
D8L98_RS05165	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D8L98_RS05170	COG1228	amidohydrolase
D8L98_RS05175	COG0659	secondary active sulfate transmembrane transporter activity
D8L98_RS05180	COG1473	amidohydrolase
D8L98_RS05200	COG0385	Bile acid
D8L98_RS05210	COG0346	lactoylglutathione lyase activity
D8L98_RS05215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D8L98_RS05240	COG1113	amino acid transport
D8L98_RS05265	COG1316	TRANSCRIPTIONal
D8L98_RS05280	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
D8L98_RS05285	COG3383	formate dehydrogenase (NAD+) activity
D8L98_RS05310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D8L98_RS05315	COG2076	Multidrug Resistance protein
D8L98_RS05320	COG2076	Multidrug Resistance protein
D8L98_RS05325	COG3942	CHAP domain
D8L98_RS05335	COG1757	Na H antiporter
D8L98_RS05345	COG3942	CHAP domain
D8L98_RS05365	COG1960	acyl-CoA dehydrogenase activity
D8L98_RS05370	COG2832	Protein of unknown function (DUF454)
D8L98_RS05375	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D8L98_RS05380	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D8L98_RS05390	COG2186	Transcriptional regulator
D8L98_RS05400	COG1268	BioY protein
D8L98_RS05415	COG1609	Transcriptional regulator
D8L98_RS05420	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D8L98_RS05425	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D8L98_RS05430	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
D8L98_RS05440	COG4149	molybdate abc transporter
D8L98_RS05445	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D8L98_RS05450	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D8L98_RS05455	COG0521	Mo-molybdopterin cofactor biosynthetic process
D8L98_RS05475	COG0314	molybdopterin synthase activity
D8L98_RS05485	COG0746	molybdenum cofactor guanylyltransferase activity
D8L98_RS05490	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D8L98_RS05515	COG2348	transferase activity, transferring amino-acyl groups
D8L98_RS05520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D8L98_RS05525	COG0436	Aminotransferase
D8L98_RS05550	COG2252	PERMEase
D8L98_RS05570	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D8L98_RS05575	COG0088	Forms part of the polypeptide exit tunnel
D8L98_RS05580	COG0089	rRNA binding
D8L98_RS05585	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D8L98_RS05590	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D8L98_RS05595	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D8L98_RS05600	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D8L98_RS05605	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D8L98_RS05610	COG0255	Belongs to the universal ribosomal protein uL29 family
D8L98_RS05620	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D8L98_RS05635	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D8L98_RS05640	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D8L98_RS05645	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D8L98_RS05655	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D8L98_RS05660	COG1841	ribosomal large subunit assembly
D8L98_RS05670	COG0201	protein transport
D8L98_RS05685	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D8L98_RS05695	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D8L98_RS05700	COG0202	RNA polymerase activity
D8L98_RS05705	COG0203	ribosomal protein L17
D8L98_RS05710	COG1122	ATPase activity
D8L98_RS05715	COG1122	ATPase activity
D8L98_RS05725	COG0101	tRNA pseudouridine synthase activity
D8L98_RS05730	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D8L98_RS05755	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D8L98_RS05760	COG3344	reverse transcriptase
D8L98_RS05800	COG1349	DNA-binding transcription factor activity
D8L98_RS05815	COG3684	Belongs to the aldolase LacD family
D8L98_RS05825	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D8L98_RS05825	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D8L98_RS05835	COG0488	(ABC) transporter
D8L98_RS05840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D8L98_RS05850	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D8L98_RS05865	COG1302	Protein conserved in bacteria
D8L98_RS05870	COG2814	Major facilitator Superfamily
D8L98_RS05875	COG4264	IucA IucC family
D8L98_RS05880	COG2814	Major facilitator Superfamily
D8L98_RS05885	COG4264	IucA IucC family
D8L98_RS05890	COG3457	Alanine racemase
D8L98_RS05895	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
D8L98_RS05900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D8L98_RS05905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D8L98_RS05910	COG3314	Sporulation integral membrane protein YlbJ
D8L98_RS05920	COG1988	membrane-bound metal-dependent
D8L98_RS05925	COG4284	Utp--glucose-1-phosphate uridylyltransferase
D8L98_RS05930	COG1272	protein, Hemolysin III
D8L98_RS05950	COG2814	Major facilitator Superfamily
D8L98_RS05955	COG0489	protein tyrosine kinase activity
D8L98_RS06020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D8L98_RS06035	COG3711	transcriptional antiterminator
D8L98_RS06055	COG1119	ATPase activity
D8L98_RS06060	COG0561	phosphatase activity
D8L98_RS06070	COG2186	Transcriptional regulator
D8L98_RS06075	COG1482	cell wall glycoprotein biosynthetic process
D8L98_RS06095	COG1757	Na H antiporter
D8L98_RS06105	COG0813	purine-nucleoside phosphorylase activity
D8L98_RS06135	COG3344	reverse transcriptase
D8L98_RS06160	COG5146	pantothenate kinase activity
D8L98_RS06175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D8L98_RS06180	COG3343	RNA polymerase activity
D8L98_RS06185	COG0504	CTP synthase activity
D8L98_RS06200	COG3344	reverse transcriptase
D8L98_RS06210	COG4821	SIS domain
D8L98_RS06215	COG0191	fructose-bisphosphate aldolase activity
D8L98_RS06220	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D8L98_RS06225	COG1733	regulation of RNA biosynthetic process
D8L98_RS06235	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D8L98_RS06240	COG0254	rRNA binding
D8L98_RS06250	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D8L98_RS06255	COG2890	protein-(glutamine-N5) methyltransferase activity
D8L98_RS06260	COG0009	L-threonylcarbamoyladenylate synthase
D8L98_RS06265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D8L98_RS06270	COG4475	Protein of unknown function (DUF436)
D8L98_RS06275	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D8L98_RS06280	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D8L98_RS06285	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D8L98_RS06295	COG0356	it plays a direct role in the translocation of protons across the membrane
D8L98_RS06300	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D8L98_RS06310	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D8L98_RS06320	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D8L98_RS06350	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D8L98_RS06365	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D8L98_RS06375	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
D8L98_RS06380	COG0352	thiamine-phosphate diphosphorylase activity
D8L98_RS06385	COG0706	membrane insertase activity
D8L98_RS06390	COG1418	mRNA catabolic process
D8L98_RS06395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D8L98_RS06400	COG1937	Protein conserved in bacteria
D8L98_RS06415	COG2217	Heavy metal translocating P-type atpase
D8L98_RS06435	COG0772	Belongs to the SEDS family
D8L98_RS06440	COG1181	Belongs to the D-alanine--D-alanine ligase family
D8L98_RS06445	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D8L98_RS06450	COG0513	Belongs to the DEAD box helicase family
D8L98_RS06465	COG3402	PFAM membrane-flanked domain
D8L98_RS06470	COG0736	holo-[acyl-carrier-protein] synthase activity
D8L98_RS06475	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D8L98_RS06485	COG2337	Toxic component of a toxin-antitoxin (TA) module
D8L98_RS06490	COG2208	phosphoserine phosphatase activity
D8L98_RS06495	COG1366	Belongs to the anti-sigma-factor antagonist family
D8L98_RS06505	COG1191	sigma factor activity
D8L98_RS06510	COG2183	response to ionizing radiation
D8L98_RS06560	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D8L98_RS06570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D8L98_RS06575	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D8L98_RS06585	COG0028	Belongs to the TPP enzyme family
D8L98_RS06590	COG0129	dihydroxy-acid dehydratase activity
D8L98_RS06595	COG0802	atpase or kinase
D8L98_RS06600	COG1214	PFAM Peptidase M22, glycoprotease
D8L98_RS06605	COG0456	acetyltransferase
D8L98_RS06610	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D8L98_RS06620	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D8L98_RS06625	COG0488	(ABC) transporter
D8L98_RS06630	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
D8L98_RS06635	COG2814	Major facilitator Superfamily
D8L98_RS06640	COG1846	Transcriptional regulator
D8L98_RS06650	COG2124	cytochrome p450
D8L98_RS06660	COG1609	Transcriptional regulator
D8L98_RS06665	COG1621	beta-fructofuranosidase activity
D8L98_RS06670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D8L98_RS06690	COG4512	PFAM Accessory gene regulator B
D8L98_RS06730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D8L98_RS06735	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D8L98_RS06750	COG1131	(ABC) transporter
D8L98_RS06765	COG1070	Carbohydrate kinase
D8L98_RS06770	COG2610	gluconate transmembrane transporter activity
D8L98_RS06800	COG2706	6-phosphogluconolactonase activity
D8L98_RS06805	COG1012	belongs to the aldehyde dehydrogenase family
D8L98_RS06815	COG1227	inorganic diphosphatase activity
D8L98_RS06820	COG1335	isochorismatase
D8L98_RS06830	COG0077	Prephenate dehydratase
D8L98_RS06830	COG1605	Chorismate mutase
D8L98_RS06840	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D8L98_RS06850	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
D8L98_RS06860	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D8L98_RS06865	COG4496	protein, YerC YecD
D8L98_RS06870	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
D8L98_RS06875	COG0210	DNA helicase
D8L98_RS06880	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D8L98_RS06885	COG4851	CamS sex pheromone cAM373 precursor
D8L98_RS06890	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D8L98_RS06895	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D8L98_RS06905	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D8L98_RS06910	COG1597	lipid kinase activity
D8L98_RS06935	COG0488	(ABC) transporter
D8L98_RS06945	COG1396	sequence-specific DNA binding
D8L98_RS06965	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D8L98_RS06975	COG1528	Iron-storage protein
D8L98_RS06990	COG4129	membrane
D8L98_RS06995	COG0024	Methionine aminopeptidase
D8L98_RS07020	COG0288	reversible hydration of carbon dioxide
D8L98_RS07025	COG1295	ribonuclease BN
D8L98_RS07040	COG4840	Belongs to the UPF0435 family
D8L98_RS07045	COG2309	aminopeptidase activity
D8L98_RS07050	COG1607	acyl-coa hydrolase
D8L98_RS07055	COG0535	radical SAM domain protein
D8L98_RS07060	COG0693	protein deglycase activity
D8L98_RS07065	COG0028	Belongs to the TPP enzyme family
D8L98_RS07070	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D8L98_RS07075	COG2137	regulation of response to DNA damage stimulus
D8L98_RS07085	COG1388	LysM domain
D8L98_RS07085	COG1134	teichoic acid transport
D8L98_RS07095	COG1988	membrane-bound metal-dependent
D8L98_RS07100	COG1194	a g-specific adenine glycosylase
D8L98_RS07105	COG3557	Belongs to the UPF0374 family
D8L98_RS07115	COG0069	glutamate synthase activity
D8L98_RS07120	COG4129	membrane
D8L98_RS07125	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D8L98_RS07130	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D8L98_RS07140	COG0735	belongs to the Fur family
D8L98_RS07375	COG0765	amino acid transport
D8L98_RS07380	COG1126	abc transporter atp-binding protein
D8L98_RS07385	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D8L98_RS07395	COG0363	glucosamine-6-phosphate deaminase activity
D8L98_RS07405	COG0114	fumarate hydratase activity
D8L98_RS07410	COG0248	Ppx GppA phosphatase
D8L98_RS07415	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D8L98_RS07420	COG0564	pseudouridine synthase activity
D8L98_RS07425	COG4585	Histidine kinase
D8L98_RS07425	COG2203	Gaf domain
D8L98_RS07430	COG2197	response regulator
D8L98_RS07440	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D8L98_RS07455	COG4399	Belongs to the UPF0754 family
D8L98_RS07460	COG3679	Belongs to the UPF0342 family
D8L98_RS07465	COG0420	3'-5' exonuclease activity
D8L98_RS07475	COG3481	metal-dependent phosphohydrolase, HD sub domain
D8L98_RS07480	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D8L98_RS07495	COG1846	Transcriptional regulator
D8L98_RS07505	COG0537	adenosine 5'-monophosphoramidase activity
D8L98_RS07510	COG1131	(ABC) transporter
D8L98_RS07515	COG4473	ABC transporter
D8L98_RS07520	COG3344	reverse transcriptase
D8L98_RS07530	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D8L98_RS07540	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D8L98_RS07545	COG3545	Serine hydrolase
D8L98_RS07635	COG3037	sugar-specific permease SgaT UlaA
D8L98_RS07655	COG3623	hexulose-6-phosphate isomerase
D8L98_RS07660	COG0235	Class ii aldolase
D8L98_RS07680	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D8L98_RS07685	COG0494	nUDIX hydrolase
D8L98_RS07690	COG1506	peptidase
D8L98_RS07695	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D8L98_RS07700	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D8L98_RS07710	COG0656	L-ascorbic acid biosynthetic process
D8L98_RS07715	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D8L98_RS07720	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D8L98_RS07730	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D8L98_RS07755	COG4193	domain, Protein
D8L98_RS07755	COG3266	domain, Protein
D8L98_RS07755	COG5632	N-Acetylmuramoyl-L-alanine amidase
D8L98_RS07765	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D8L98_RS07765	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D8L98_RS07770	COG0307	riboflavin synthase, alpha
D8L98_RS07775	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D8L98_RS07775	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D8L98_RS07780	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D8L98_RS07795	COG2267	carboxylic ester hydrolase activity
D8L98_RS07800	COG0039	L-malate dehydrogenase activity
D8L98_RS07810	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
D8L98_RS07815	COG1242	4 iron, 4 sulfur cluster binding
D8L98_RS07820	COG2814	Major facilitator Superfamily
D8L98_RS07825	COG0495	leucyl-tRNA aminoacylation
D8L98_RS07830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D8L98_RS07835	COG2081	HI0933 family
D8L98_RS07840	COG2244	polysaccharide biosynthetic process
D8L98_RS07845	COG1187	pseudouridine synthase activity
D8L98_RS07855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D8L98_RS07860	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D8L98_RS07865	COG0510	thiamine kinase activity
D8L98_RS07870	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D8L98_RS07875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D8L98_RS07885	COG1363	Peptidase, m42
D8L98_RS07890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D8L98_RS07895	COG4848	Belongs to the UPF0354 family
D8L98_RS07900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D8L98_RS07905	COG1674	ftsk spoiiie
D8L98_RS07910	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D8L98_RS07915	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
D8L98_RS07925	COG1605	Chorismate mutase
D8L98_RS07925	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
D8L98_RS07930	COG1609	Transcriptional regulator
D8L98_RS07935	COG3344	reverse transcriptase
D8L98_RS07945	COG0454	-acetyltransferase
D8L98_RS07950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D8L98_RS07955	COG2759	Belongs to the formate--tetrahydrofolate ligase family
D8L98_RS07960	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D8L98_RS07970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D8L98_RS07975	COG0204	Acyl-transferase
D8L98_RS07985	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D8L98_RS07990	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D8L98_RS07995	COG1764	response to oxidative stress
D8L98_RS08035	COG0456	acetyltransferase
D8L98_RS08065	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D8L98_RS08070	COG1956	GAF domain-containing protein
D8L98_RS08075	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
D8L98_RS08080	COG1104	cysteine desulfurase activity
D8L98_RS08085	COG0301	tRNA thio-modification
D8L98_RS08095	COG0616	signal peptide processing
D8L98_RS08100	COG1714	RDD family
D8L98_RS08105	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D8L98_RS08110	COG0827	DNA restriction-modification system
D8L98_RS08115	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D8L98_RS08120	COG0589	response to stress
D8L98_RS08125	COG0686	Belongs to the AlaDH PNT family
D8L98_RS08135	COG0006	proline dipeptidase activity
D8L98_RS08140	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D8L98_RS08150	COG4109	DRTGG domain
D8L98_RS08155	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D8L98_RS08160	COG0587	DNA-directed DNA polymerase activity
D8L98_RS08165	COG0281	malic enzyme
D8L98_RS08170	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D8L98_RS08175	COG0825	malonyl-CoA metabolic process
D8L98_RS08180	COG0205	6-phosphofructokinase activity
D8L98_RS08185	COG0469	pyruvate kinase activity
D8L98_RS08190	COG0372	Belongs to the citrate synthase family
D8L98_RS08195	COG0538	isocitrate dehydrogenase activity
D8L98_RS08200	COG0745	RESPONSE REGULATOR receiver
D8L98_RS08205	COG5002	protein histidine kinase activity
D8L98_RS08210	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D8L98_RS08210	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D8L98_RS08220	COG0237	dephospho-CoA kinase activity
D8L98_RS08235	COG3611	Membrane attachment protein
D8L98_RS08240	COG1484	DNA-dependent DNA replication
D8L98_RS08250	COG0833	amino acid
D8L98_RS08255	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D8L98_RS08260	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D8L98_RS08265	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D8L98_RS08280	COG0544	peptidyl-prolyl cis-trans isomerase activity
D8L98_RS08290	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D8L98_RS08295	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D8L98_RS08305	COG0181	hydroxymethylbilane synthase activity
D8L98_RS08320	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D8L98_RS08330	COG2818	Glycosylase
D8L98_RS08335	COG0525	valine-tRNA ligase activity
D8L98_RS08340	COG0285	dihydrofolate synthase activity
D8L98_RS08350	COG2003	Belongs to the UPF0758 family
D8L98_RS08380	COG2868	ribosomal protein
D8L98_RS08390	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D8L98_RS08400	COG0632	four-way junction helicase activity
D8L98_RS08405	COG2255	four-way junction helicase activity
D8L98_RS08410	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D8L98_RS08420	COG1862	Preprotein translocase
D8L98_RS08425	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D8L98_RS08425	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D8L98_RS08430	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D8L98_RS08430	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D8L98_RS08435	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D8L98_RS08445	COG1490	D-aminoacyl-tRNA deacylase activity
D8L98_RS08450	COG0860	N-Acetylmuramoyl-L-alanine amidase
D8L98_RS08460	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D8L98_RS08470	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D8L98_RS08475	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D8L98_RS08480	COG1959	2 iron, 2 sulfur cluster binding
D8L98_RS08495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D8L98_RS08500	COG1104	cysteine desulfurase activity
D8L98_RS08505	COG0482	sulfurtransferase activity
D8L98_RS08515	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D8L98_RS08520	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D8L98_RS08525	COG4472	Bacterial protein of unknown function (DUF965)
D8L98_RS08530	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D8L98_RS08535	COG3906	Belongs to the UPF0473 family
D8L98_RS08540	COG4122	O-methyltransferase activity
D8L98_RS08545	COG0826	peptidase U32
D8L98_RS08550	COG0826	peptidase U32
D8L98_RS08555	COG0572	uridine kinase
D8L98_RS08565	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D8L98_RS08570	COG1984	allophanate hydrolase subunit 2
D8L98_RS08575	COG0511	ligase activity, forming carbon-carbon bonds
D8L98_RS08580	COG0439	Biotin carboxylase
D8L98_RS08585	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D8L98_RS08590	COG1914	H( )-stimulated, divalent metal cation uptake system
D8L98_RS08595	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D8L98_RS08600	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
D8L98_RS08605	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D8L98_RS08610	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D8L98_RS08615	COG1534	Rna-binding protein
D8L98_RS08625	COG1713	HD superfamily hydrolase involved in NAD metabolism
D8L98_RS08630	COG0799	negative regulation of ribosome biogenesis
D8L98_RS08635	COG2226	methyltransferase
D8L98_RS08640	COG1555	photosystem II stabilization
D8L98_RS08640	COG1596	polysaccharide export
D8L98_RS08645	COG2131	deaminase
D8L98_RS08650	COG2333	competence protein COMEC
D8L98_RS08650	COG0658	competence protein
D8L98_RS08655	COG1466	dna polymerase III delta subunit
D8L98_RS08660	COG0268	Binds directly to 16S ribosomal RNA
D8L98_RS08670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D8L98_RS08690	COG0484	heat shock protein binding
D8L98_RS08695	COG2264	protein methyltransferase activity
D8L98_RS08700	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D8L98_RS08705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D8L98_RS08720	COG1030	water channel activity
D8L98_RS08725	COG4864	UPF0365 protein
D8L98_RS08735	COG1702	phosphate starvation-inducible protein PhoH
D8L98_RS08745	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D8L98_RS08755	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D8L98_RS08760	COG1381	Involved in DNA repair and RecF pathway recombination
D8L98_RS08765	COG0423	glycine-tRNA ligase activity
D8L98_RS08770	COG0517	IMP dehydrogenase activity
D8L98_RS08775	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D8L98_RS08780	COG0358	DNA primase activity
D8L98_RS08785	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D8L98_RS08790	COG2384	SAM-dependent methyltransferase
D8L98_RS08795	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D8L98_RS08800	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D8L98_RS08805	COG0513	Belongs to the DEAD box helicase family
D8L98_RS08810	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
D8L98_RS08815	COG1121	(ABC) transporter
D8L98_RS08820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D8L98_RS08825	COG0735	belongs to the Fur family
D8L98_RS08830	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D8L98_RS08840	COG0768	penicillin binding
D8L98_RS08845	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D8L98_RS08850	COG0573	inorganic phosphate transmembrane transporter activity
D8L98_RS08855	COG0581	inorganic phosphate transmembrane transporter activity
D8L98_RS08860	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D8L98_RS08865	COG0704	Plays a role in the regulation of phosphate uptake
D8L98_RS08875	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D8L98_RS08880	COG0705	Rhomboid family
D8L98_RS08885	COG4483	Protein conserved in bacteria
D8L98_RS08890	COG1940	carbohydrate kinase activity
D8L98_RS08895	COG0011	TIGRFAM Protein of
D8L98_RS08900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D8L98_RS08910	COG0582	viral genome integration into host DNA
D8L98_RS09000	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D8L98_RS09160	COG4824	toxin secretion phage lysis holin
D8L98_RS09195	COG3969	phosphoadenosine phosphosulfate
D8L98_RS09200	COG1475	DNA binding
D8L98_RS09240	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D8L98_RS09245	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D8L98_RS09255	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D8L98_RS09260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D8L98_RS09265	COG0095	Lipoate-protein ligase
D8L98_RS09280	COG0006	proline dipeptidase activity
D8L98_RS09285	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D8L98_RS09290	COG0511	ligase activity, forming carbon-carbon bonds
D8L98_RS09295	COG0439	Biotin carboxylase
D8L98_RS09300	COG1302	Protein conserved in bacteria
D8L98_RS09310	COG1570	exodeoxyribonuclease VII activity
D8L98_RS09315	COG1722	exodeoxyribonuclease VII activity
D8L98_RS09325	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D8L98_RS09330	COG1438	arginine binding
D8L98_RS09335	COG0497	DNA recombination
D8L98_RS09340	COG0280	phosphate acetyltransferase
D8L98_RS09345	COG3426	butyrate kinase activity
D8L98_RS09350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D8L98_RS09355	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D8L98_RS09360	COG0022	dehydrogenase e1 component
D8L98_RS09365	COG0508	dehydrogenase complex catalyzes the overall conversion of
D8L98_RS09375	COG4129	membrane
D8L98_RS09380	COG2195	Cleaves the N-terminal amino acid of tripeptides
D8L98_RS09410	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D8L98_RS09415	COG1234	tRNA 3'-trailer cleavage
D8L98_RS09420	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D8L98_RS09430	COG0667	Aldo Keto reductase
D8L98_RS09435	COG0494	nUDIX hydrolase
D8L98_RS09440	COG0735	belongs to the Fur family
D8L98_RS09455	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D8L98_RS09460	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D8L98_RS09465	COG1187	pseudouridine synthase activity
D8L98_RS09470	COG0745	RESPONSE REGULATOR receiver
D8L98_RS09485	COG1141	Ferredoxin
D8L98_RS09495	COG0514	ATP-dependent DNA helicase (RecQ)
D8L98_RS09505	COG0492	ferredoxin-NADP+ reductase activity
D8L98_RS09510	COG0252	asparaginase activity
D8L98_RS09520	COG0539	negative regulation of cytoplasmic translation
D8L98_RS09525	COG3344	reverse transcriptase
D8L98_RS09530	COG1160	GTP binding
D8L98_RS09535	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D8L98_RS09555	COG0142	geranyltranstransferase activity
D8L98_RS09560	COG0105	UTP biosynthetic process
D8L98_RS09570	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D8L98_RS09580	COG0457	Tetratricopeptide repeat
D8L98_RS09585	COG5582	Belongs to the UPF0302 family
D8L98_RS09590	COG4347	Protein of unknown function (DUF1405)
D8L98_RS09600	COG1694	Mazg nucleotide pyrophosphohydrolase
D8L98_RS09605	COG0438	transferase activity, transferring glycosyl groups
D8L98_RS09610	COG0617	tRNA 3'-terminal CCA addition
D8L98_RS09625	COG0017	Asparaginyl-tRNA synthetase
D8L98_RS09635	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D8L98_RS09645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D8L98_RS09645	COG4499	WXG100 protein secretion system (Wss), protein YukC
D8L98_RS09660	COG4474	Belongs to the UPF0398 family
D8L98_RS09665	COG3599	regulation of cell shape
D8L98_RS09675	COG0116	Belongs to the methyltransferase superfamily
D8L98_RS09680	COG2962	Rard protein
D8L98_RS09685	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
D8L98_RS09690	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D8L98_RS09700	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D8L98_RS09710	COG1413	lyase activity
D8L98_RS09745	COG2190	(PTS) system
D8L98_RS09755	COG0793	Belongs to the peptidase S41A family
D8L98_RS09770	COG0671	phosphoesterase, PA-phosphatase related
D8L98_RS09780	COG5002	protein histidine kinase activity
D8L98_RS09785	COG0567	Dehydrogenase, E1 component
D8L98_RS09810	COG0714	Associated with various cellular activities
D8L98_RS09815	COG4548	von Willebrand factor, type A
D8L98_RS09820	COG1114	Component of the transport system for branched-chain amino acids
D8L98_RS09825	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D8L98_RS09835	COG3853	Toxic anion resistance protein (TelA)
D8L98_RS09855	COG1278	Cold shock
D8L98_RS09875	COG1473	amidohydrolase
D8L98_RS09880	COG2171	N-acyltransferase activity
D8L98_RS09885	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D8L98_RS09890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D8L98_RS09895	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D8L98_RS09900	COG0488	(ABC) transporter
D8L98_RS09905	COG2996	Protein conserved in bacteria
D8L98_RS09935	COG1363	Peptidase, m42
D8L98_RS09940	COG0287	Prephenate dehydrogenase
D8L98_RS09945	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D8L98_RS09955	COG1942	4-Oxalocrotonate Tautomerase
D8L98_RS09975	COG0628	permease
D8L98_RS09985	COG3711	transcriptional antiterminator
D8L98_RS09990	COG1115	amino acid carrier protein
D8L98_RS09995	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D8L98_RS10005	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D8L98_RS10010	COG4841	protein insertion into membrane
D8L98_RS10015	COG0824	Thioesterase
D8L98_RS10025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D8L98_RS10030	COG1970	mechanosensitive ion channel activity
D8L98_RS10035	COG0419	ATPase involved in DNA repair
D8L98_RS10040	COG0420	3'-5' exonuclease activity
D8L98_RS10045	COG4846	Membrane protein involved in cytochrome C biogenesis
D8L98_RS10050	COG3763	UPF0154 protein
D8L98_RS10060	COG4224	UPF0291 protein
D8L98_RS10070	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D8L98_RS10080	COG0516	GMP reductase activity
D8L98_RS10085	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D8L98_RS10095	COG0833	amino acid
D8L98_RS10110	COG0083	homoserine kinase activity
D8L98_RS10115	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D8L98_RS10120	COG0460	homoserine dehydrogenase
D8L98_RS10125	COG0527	aspartate kinase activity
D8L98_RS10145	COG3344	reverse transcriptase
D8L98_RS10150	COG1525	nuclease
D8L98_RS10180	COG0584	glycerophosphoryl diester phosphodiesterase
D8L98_RS10260	COG0789	Transcriptional regulator
D8L98_RS10265	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
D8L98_RS10270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D8L98_RS10275	COG0386	Belongs to the glutathione peroxidase family
D8L98_RS10285	COG2267	carboxylic ester hydrolase activity
D8L98_RS10290	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D8L98_RS10295	COG1923	regulation of RNA biosynthetic process
D8L98_RS10300	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D8L98_RS10310	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D8L98_RS10315	COG1619	proteins homologs of microcin C7 resistance protein MccF
D8L98_RS10320	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
D8L98_RS10325	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D8L98_RS10345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D8L98_RS10355	COG1013	pyruvate-flavodoxin oxidoreductase activity
D8L98_RS10360	COG0674	pyruvate-flavodoxin oxidoreductase activity
D8L98_RS10360	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D8L98_RS10365	COG1692	metallophosphoesterase
D8L98_RS10385	COG1418	mRNA catabolic process
D8L98_RS10390	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D8L98_RS10395	COG1546	Belongs to the CinA family
D8L98_RS10395	COG1058	Belongs to the CinA family
D8L98_RS10415	COG0300	oxidoreductase activity
D8L98_RS10420	COG0612	Peptidase, M16
D8L98_RS10425	COG0612	Peptidase, M16
D8L98_RS10430	COG2188	Transcriptional regulator
D8L98_RS10450	COG1185	polyribonucleotide nucleotidyltransferase activity
D8L98_RS10460	COG0196	riboflavin kinase activity
D8L98_RS10465	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D8L98_RS10470	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D8L98_RS10480	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D8L98_RS10485	COG1358	cellular component organization or biogenesis
D8L98_RS10490	COG2740	Nucleic-acid-binding protein implicated in transcription termination
D8L98_RS10495	COG0195	Participates in both transcription termination and antitermination
D8L98_RS10500	COG0779	Required for maturation of 30S ribosomal subunits
D8L98_RS10510	COG0442	prolyl-tRNA aminoacylation
D8L98_RS10520	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D8L98_RS10525	COG4589	Belongs to the CDS family
D8L98_RS10535	COG0233	cytoplasmic translational termination
D8L98_RS10540	COG0528	UMP kinase activity
D8L98_RS10545	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D8L98_RS10550	COG0052	Belongs to the universal ribosomal protein uS2 family
D8L98_RS10555	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
D8L98_RS10560	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D8L98_RS10565	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D8L98_RS10570	COG4974	Belongs to the 'phage' integrase family
D8L98_RS10575	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
D8L98_RS10580	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D8L98_RS10585	COG0758	DNA mediated transformation
D8L98_RS10595	COG0045	succinate-CoA ligase (ADP-forming) activity
D8L98_RS10605	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D8L98_RS10620	COG4485	Bacterial membrane protein, YfhO
D8L98_RS10660	COG0336	Belongs to the RNA methyltransferase TrmD family
D8L98_RS10665	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D8L98_RS10670	COG0228	four-way junction DNA binding
D8L98_RS10690	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D8L98_RS10705	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D8L98_RS10710	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
D8L98_RS10715	COG0552	protein localization to endoplasmic reticulum
D8L98_RS10720	COG1196	nuclear chromosome segregation
D8L98_RS10725	COG0571	ribonuclease III activity
D8L98_RS10730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D8L98_RS10745	COG0416	fatty acid biosynthetic process
D8L98_RS10750	COG1349	DNA-binding transcription factor activity
D8L98_RS10760	COG1760	l-serine dehydratase
D8L98_RS10765	COG1760	l-serine dehydratase
D8L98_RS10775	COG1302	Protein conserved in bacteria
D8L98_RS10790	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D8L98_RS10795	COG1162	GTPase activity
D8L98_RS10800	COG2124	cytochrome p450
D8L98_RS10815	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D8L98_RS10820	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D8L98_RS10820	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D8L98_RS10825	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D8L98_RS10830	COG0242	peptide deformylase activity
D8L98_RS10835	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D8L98_RS10840	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D8L98_RS10860	COG1758	RNA polymerase activity
D8L98_RS10880	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D8L98_RS10885	COG0284	orotidine-5'-phosphate decarboxylase activity
D8L98_RS10890	COG0167	dihydroorotate dehydrogenase activity
D8L98_RS10900	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D8L98_RS10905	COG0505	Belongs to the CarA family
D8L98_RS10925	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D8L98_RS10930	COG0564	pseudouridine synthase activity
D8L98_RS10935	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D8L98_RS10940	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D8L98_RS10945	COG3599	regulation of cell shape
D8L98_RS10965	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D8L98_RS10970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D8L98_RS10980	COG4975	Glucose uptake
D8L98_RS10985	COG1869	D-ribose catabolic process
D8L98_RS10990	COG0762	integral membrane protein
D8L98_RS10995	COG1799	cell septum assembly
D8L98_RS11000	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D8L98_RS11010	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D8L98_RS11015	COG0849	cell division
D8L98_RS11025	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D8L98_RS11035	COG0768	penicillin binding
D8L98_RS11040	COG4839	cell division protein FtsL
D8L98_RS11045	COG0275	rRNA processing
D8L98_RS11050	COG2001	Belongs to the MraZ family
D8L98_RS11055	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
D8L98_RS11060	COG0454	-acetyltransferase
D8L98_RS11065	COG1011	Hydrolase
D8L98_RS11080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D8L98_RS11135	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D8L98_RS11140	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D8L98_RS11145	COG1053	succinate dehydrogenase
D8L98_RS11150	COG2009	succinate dehydrogenase
D8L98_RS11155	COG0322	excinuclease ABC activity
D8L98_RS11160	COG3118	belongs to the thioredoxin family
D8L98_RS11165	COG1193	negative regulation of DNA recombination
D8L98_RS11170	COG1796	DNA polymerase
D8L98_RS11170	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D8L98_RS11185	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D8L98_RS11200	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D8L98_RS11205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D8L98_RS11210	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D8L98_RS11230	COG0742	ribosomal rna small subunit methyltransferase
D8L98_RS11240	COG4471	UPF0298 protein
D8L98_RS11245	COG0584	glycerophosphoryl diester phosphodiesterase
D8L98_RS11250	COG3679	Belongs to the UPF0342 family
D8L98_RS11265	COG0109	protoheme IX farnesyltransferase activity
D8L98_RS11285	COG3344	reverse transcriptase
D8L98_RS11290	COG0772	Belongs to the SEDS family
D8L98_RS11295	COG4838	Belongs to the UPF0358 family
D8L98_RS11300	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D8L98_RS11305	COG4896	Protein conserved in bacteria
D8L98_RS11310	COG1902	pentaerythritol trinitrate reductase activity
D8L98_RS11315	COG1217	gtp-binding protein TYPA
D8L98_RS11325	COG0483	inositol monophosphate 1-phosphatase activity
D8L98_RS11330	COG4493	Belongs to the UPF0637 family
D8L98_RS11345	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D8L98_RS11350	COG1177	transmembrane transport
D8L98_RS11360	COG3842	ATPase activity
D8L98_RS11370	COG4476	Belongs to the UPF0223 family
D8L98_RS11410	COG5503	Protein of unknown function (DUF1447)
D8L98_RS11415	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D8L98_RS11420	COG0492	ferredoxin-NADP+ reductase activity
D8L98_RS11440	COG3344	reverse transcriptase
D8L98_RS11445	COG0569	domain protein
D8L98_RS11450	COG1294	oxidase, subunit
D8L98_RS11455	COG1271	oxidase subunit
D8L98_RS11460	COG1393	Belongs to the ArsC family
D8L98_RS11465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D8L98_RS11470	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D8L98_RS11480	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D8L98_RS11495	COG4172	Belongs to the ABC transporter superfamily
D8L98_RS11505	COG0151	Belongs to the GarS family
D8L98_RS11510	COG0138	bifunctional purine biosynthesis protein purh
D8L98_RS11520	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D8L98_RS11525	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D8L98_RS11535	COG0047	phosphoribosylformylglycinamidine synthase activity
D8L98_RS11540	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D8L98_RS11545	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D8L98_RS11550	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D8L98_RS11555	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D8L98_RS11560	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D8L98_RS11565	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D8L98_RS11565	COG1017	nitric oxide dioxygenase activity
D8L98_RS11575	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D8L98_RS11585	COG1845	cytochrome c oxidase, subunit III
D8L98_RS11590	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D8L98_RS11600	COG3973	AAA domain
D8L98_RS11645	COG3212	peptidase
D8L98_RS11660	COG1134	teichoic acid transport
D8L98_RS11670	COG1682	transport, permease protein
D8L98_RS11680	COG1215	transferase activity, transferring glycosyl groups
D8L98_RS11690	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D8L98_RS11695	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D8L98_RS11700	COG1316	TRANSCRIPTIONal
D8L98_RS11725	COG3594	Acyltransferase
D8L98_RS11730	COG0436	Aminotransferase
D8L98_RS11735	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D8L98_RS11745	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
D8L98_RS11750	COG1169	isochorismate synthase
D8L98_RS11755	COG1575	Belongs to the MenA family. Type 1 subfamily
D8L98_RS11760	COG0390	transport system, permease component
D8L98_RS11765	COG4619	ABC transporter
D8L98_RS11785	COG4873	Protein conserved in bacteria
D8L98_RS11865	COG0456	acetyltransferase
D8L98_RS11875	COG2226	methyltransferase
D8L98_RS11920	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D8L98_RS11920	COG0551	DNA topoisomerase type I activity
D8L98_RS11960	COG0737	Belongs to the 5'-nucleotidase family
D8L98_RS11970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D8L98_RS11975	COG1696	Membrane protein involved in D-alanine export
D8L98_RS11985	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
D8L98_RS11990	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D8L98_RS11995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D8L98_RS12000	COG0861	Integral membrane protein TerC family
D8L98_RS12005	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D8L98_RS12015	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D8L98_RS12025	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D8L98_RS12030	COG2814	Major facilitator Superfamily
D8L98_RS12040	COG3715	PTS system
D8L98_RS12045	COG3716	PTS system mannose fructose sorbose family IID component
D8L98_RS12050	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D8L98_RS12055	COG2382	esterase
D8L98_RS12060	COG1115	amino acid carrier protein
D8L98_RS12065	COG0628	permease
D8L98_RS12070	COG4409	exo-alpha-(2->6)-sialidase activity
D8L98_RS12075	COG2211	Major facilitator Superfamily
D8L98_RS12080	COG0673	inositol 2-dehydrogenase activity
D8L98_RS12090	COG0475	glutathione-regulated potassium exporter activity
D8L98_RS12090	COG0569	domain protein
D8L98_RS12095	COG2239	Acts as a magnesium transporter
D8L98_RS12100	COG0564	pseudouridine synthase activity
D8L98_RS12110	COG2357	RelA SpoT domain protein
D8L98_RS12125	COG2346	COG2346, Truncated hemoglobins
D8L98_RS12130	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D8L98_RS12140	COG1164	Oligoendopeptidase f
D8L98_RS12155	COG3591	Belongs to the peptidase S1B family
D8L98_RS12165	COG1393	Belongs to the ArsC family
D8L98_RS12170	COG0180	Tryptophanyl-tRNA synthetase
D8L98_RS12175	COG4166	transmembrane transport
D8L98_RS12180	COG4608	Belongs to the ABC transporter superfamily
D8L98_RS12185	COG0444	Belongs to the ABC transporter superfamily
D8L98_RS12190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D8L98_RS12195	COG0601	transmembrane transport
D8L98_RS12220	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
D8L98_RS12240	COG0561	phosphatase activity
D8L98_RS12245	COG0446	pyridine nucleotide-disulphide oxidoreductase
D8L98_RS12250	COG3344	reverse transcriptase
D8L98_RS12260	COG0179	Fumarylacetoacetate (FAA) hydrolase
D8L98_RS12270	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
D8L98_RS12285	COG0166	Belongs to the GPI family
D8L98_RS12290	COG0137	argininosuccinate synthase activity
D8L98_RS12300	COG0584	glycerophosphoryl diester phosphodiesterase
D8L98_RS12315	COG1012	belongs to the aldehyde dehydrogenase family
D8L98_RS12320	COG1098	S1 RNA binding domain
D8L98_RS12335	COG1278	Cold shock
D8L98_RS12385	COG1131	(ABC) transporter
D8L98_RS12415	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D8L98_RS12425	COG2111	Na H antiporter
D8L98_RS12425	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D8L98_RS12430	COG2111	Na H antiporter
D8L98_RS12435	COG1006	Multisubunit Na H antiporter MnhC subunit
D8L98_RS12440	COG0651	ATP synthesis coupled electron transport
D8L98_RS12445	COG1863	multisubunit Na H antiporter MnhE subunit
D8L98_RS12450	COG2212	antiporter activity
D8L98_RS12455	COG1320	monovalent cation:proton antiporter activity
D8L98_RS12465	COG2056	Na+-H+ antiporter family
D8L98_RS12470	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D8L98_RS12475	COG1252	NADH dehydrogenase
D8L98_RS12480	COG0316	Belongs to the HesB IscA family
D8L98_RS12485	COG4844	belongs to the
D8L98_RS12490	COG1252	NADH dehydrogenase
D8L98_RS12495	COG4837	Protein of unknown function (DUF1462)
D8L98_RS12500	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D8L98_RS12505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D8L98_RS12510	COG0647	UMP catabolic process
D8L98_RS12515	COG2445	Protein of unknown function DUF86
D8L98_RS12525	COG4470	Protein conserved in bacteria
D8L98_RS12530	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D8L98_RS12535	COG0737	Belongs to the 5'-nucleotidase family
D8L98_RS12540	COG0730	response to heat
D8L98_RS12545	COG1801	Protein of unknown function DUF72
D8L98_RS12560	COG1253	flavin adenine dinucleotide binding
D8L98_RS12580	COG1388	LysM domain
D8L98_RS12580	COG5632	N-Acetylmuramoyl-L-alanine amidase
D8L98_RS12695	COG1783	phage Terminase large subunit
D8L98_RS12700	COG3728	DNA packaging
D8L98_RS12700	COG5484	DNA packaging
D8L98_RS12720	COG0756	dUTP diphosphatase activity
D8L98_RS12785	COG0305	Participates in initiation and elongation during chromosome replication
D8L98_RS12895	COG0719	Fe-S assembly protein
D8L98_RS12900	COG0822	iron-sulfur transferase activity
D8L98_RS12910	COG0719	Fe-S assembly protein
D8L98_RS12915	COG0396	ATPase activity
D8L98_RS12930	COG1464	Belongs to the NlpA lipoprotein family
D8L98_RS12935	COG1464	Belongs to the NlpA lipoprotein family
D8L98_RS12940	COG2011	ABC-type metal ion transport system permease component
D8L98_RS12950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D8L98_RS12955	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
D8L98_RS12965	COG1393	Belongs to the ArsC family
D8L98_RS12970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D8L98_RS12980	COG0710	3-dehydroquinate dehydratase activity
D8L98_RS12990	COG1764	response to oxidative stress
D8L98_RS13005	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D8L98_RS13025	COG0346	lactoylglutathione lyase activity
D8L98_RS13055	COG0557	exoribonuclease II activity
D8L98_RS13060	COG1647	Serine aminopeptidase, S33
D8L98_RS13065	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D8L98_RS13095	COG0148	phosphopyruvate hydratase activity
D8L98_RS13100	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D8L98_RS13105	COG0149	triose-phosphate isomerase activity
D8L98_RS13110	COG0126	phosphoglycerate kinase activity
D8L98_RS13135	COG1090	epimerase
D8L98_RS13145	COG0740	serine-type endopeptidase activity