locus-tag	class	description
SPSINT_RS00010	COG0594	ribonuclease P activity
SPSINT_RS00015	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SPSINT_RS00020	COG0445	tRNA wobble uridine modification
SPSINT_RS00025	COG0357	Ribosomal RNA small subunit methyltransferase G
SPSINT_RS00045	COG0400	carboxylic ester hydrolase activity
SPSINT_RS00050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SPSINT_RS00055	COG0346	lactoylglutathione lyase activity
SPSINT_RS00060	COG1846	Transcriptional regulator
SPSINT_RS00065	COG2388	GCN5-related N-acetyl-transferase
SPSINT_RS00075	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SPSINT_RS00080	COG0830	nickel cation binding
SPSINT_RS00090	COG0829	nickel cation binding
SPSINT_RS00095	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SPSINT_RS00100	COG0646	methionine synthase
SPSINT_RS00100	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SPSINT_RS00105	COG0626	cystathionine gamma-synthase activity
SPSINT_RS00110	COG0626	cystathionine gamma-synthase activity
SPSINT_RS00115	COG1475	DNA binding
SPSINT_RS00120	COG0668	transmembrane transport
SPSINT_RS00125	COG4481	Protein conserved in bacteria
SPSINT_RS00130	COG0012	GTP binding
SPSINT_RS00150	COG1131	(ABC) transporter
SPSINT_RS00155	COG1668	transmembrane transport
SPSINT_RS00165	COG0360	Binds together with S18 to 16S ribosomal RNA
SPSINT_RS00175	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SPSINT_RS00185	COG0753	catalase activity
SPSINT_RS00190	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SPSINT_RS00195	COG1464	Belongs to the NlpA lipoprotein family
SPSINT_RS00200	COG2011	ABC-type metal ion transport system permease component
SPSINT_RS00205	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPSINT_RS00215	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SPSINT_RS00230	COG0450	alkyl hydroperoxide reductase
SPSINT_RS00235	COG0778	Nitroreductase
SPSINT_RS00250	COG0577	efflux transmembrane transporter activity
SPSINT_RS00250	COG1136	(ABC) transporter
SPSINT_RS00255	COG1823	symporter activity
SPSINT_RS00260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SPSINT_RS00265	COG5183	chlorophyll binding
SPSINT_RS00280	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPSINT_RS00285	COG2233	PERMEase
SPSINT_RS00290	COG0516	GMP reductase activity
SPSINT_RS00290	COG0517	IMP dehydrogenase activity
SPSINT_RS00295	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SPSINT_RS00295	COG0519	Catalyzes the synthesis of GMP from XMP
SPSINT_RS00340	COG1525	nuclease
SPSINT_RS00360	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
SPSINT_RS00385	COG0747	negative chemotaxis
SPSINT_RS00390	COG0601	transmembrane transport
SPSINT_RS00395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPSINT_RS00400	COG0444	Belongs to the ABC transporter superfamily
SPSINT_RS00405	COG1124	(ABC) transporter
SPSINT_RS00420	COG2814	Major facilitator Superfamily
SPSINT_RS00425	COG0730	response to heat
SPSINT_RS00430	COG1937	Protein conserved in bacteria
SPSINT_RS00435	COG2210	Belongs to the sulfur carrier protein TusA family
SPSINT_RS00455	COG1263	PTS System
SPSINT_RS00455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPSINT_RS00460	COG1486	melibiose metabolic process
SPSINT_RS00470	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SPSINT_RS00500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SPSINT_RS00500	COG0574	Belongs to the PEP-utilizing enzyme family
SPSINT_RS00505	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SPSINT_RS00520	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
SPSINT_RS00525	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
SPSINT_RS00530	COG2205	protein histidine kinase activity
SPSINT_RS00535	COG0745	RESPONSE REGULATOR receiver
SPSINT_RS00545	COG0733	neurotransmitter:sodium symporter activity
SPSINT_RS00550	COG2272	Belongs to the type-B carboxylesterase lipase family
SPSINT_RS00555	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SPSINT_RS00560	COG0626	cystathionine gamma-synthase activity
SPSINT_RS00605	COG1131	(ABC) transporter
SPSINT_RS00620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPSINT_RS00635	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SPSINT_RS00650	COG0583	DNA-binding transcription factor activity
SPSINT_RS00655	COG0069	glutamate synthase activity
SPSINT_RS00655	COG0070	glutamate synthase
SPSINT_RS00655	COG0067	glutamate synthase
SPSINT_RS00660	COG0493	'glutamate synthase
SPSINT_RS00670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPSINT_RS00670	COG1263	PTS System
SPSINT_RS00675	COG0366	Alpha amylase catalytic
SPSINT_RS00680	COG2188	Transcriptional regulator
SPSINT_RS00685	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
SPSINT_RS00690	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SPSINT_RS00695	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SPSINT_RS00700	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SPSINT_RS00725	COG1982	Orn Lys Arg decarboxylase major
SPSINT_RS00730	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SPSINT_RS00735	COG3870	Protein conserved in bacteria
SPSINT_RS00740	COG0470	DNA polymerase III
SPSINT_RS00745	COG1774	PSP1 C-terminal conserved region
SPSINT_RS00750	COG4467	Involved in initiation control of chromosome replication
SPSINT_RS00755	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SPSINT_RS00760	COG2827	Endonuclease containing a URI domain
SPSINT_RS00765	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SPSINT_RS00775	COG0084	hydrolase, TatD family'
SPSINT_RS00780	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SPSINT_RS00790	COG4466	Protein conserved in bacteria
SPSINT_RS00795	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SPSINT_RS00800	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPSINT_RS00805	COG0251	oxidation-reduction process
SPSINT_RS00810	COG2088	sporulation resulting in formation of a cellular spore
SPSINT_RS00815	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SPSINT_RS00820	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SPSINT_RS00830	COG0193	aminoacyl-tRNA hydrolase activity
SPSINT_RS00835	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SPSINT_RS00840	COG2244	polysaccharide biosynthetic process
SPSINT_RS00845	COG3956	TIGRFAM MazG family protein
SPSINT_RS00850	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SPSINT_RS00860	COG1098	S1 RNA binding domain
SPSINT_RS00875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SPSINT_RS00880	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SPSINT_RS00890	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
SPSINT_RS00900	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SPSINT_RS00905	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
SPSINT_RS00995	COG1289	transmembrane transporter activity
SPSINT_RS01000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SPSINT_RS01005	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SPSINT_RS01010	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SPSINT_RS01020	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SPSINT_RS01030	COG3880	PFAM UvrB UvrC protein
SPSINT_RS01035	COG3869	Catalyzes the specific phosphorylation of arginine residues in
SPSINT_RS01040	COG0542	response to heat
SPSINT_RS01075	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SPSINT_RS01080	COG4956	integral membrane protein (PIN domain superfamily)
SPSINT_RS01085	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SPSINT_RS01095	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SPSINT_RS01100	COG1045	serine acetyltransferase
SPSINT_RS01105	COG0215	cysteine-tRNA ligase activity
SPSINT_RS01110	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SPSINT_RS01130	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SPSINT_RS01135	COG0250	Participates in transcription elongation, termination and antitermination
SPSINT_RS01140	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SPSINT_RS01145	COG0081	regulation of translation
SPSINT_RS01150	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SPSINT_RS01160	COG2813	Specifically methylates the guanine in position
SPSINT_RS01165	COG0085	RNA polymerase activity
SPSINT_RS01170	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SPSINT_RS01180	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SPSINT_RS01185	COG0049	tRNA binding
SPSINT_RS01190	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SPSINT_RS01195	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SPSINT_RS01200	COG3527	Alpha-acetolactate decarboxylase
SPSINT_RS01205	COG1473	amidohydrolase
SPSINT_RS01215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SPSINT_RS01255	COG0546	phosphoglycolate phosphatase activity
SPSINT_RS01260	COG1428	Deoxynucleoside kinase
SPSINT_RS01265	COG1428	Deoxynucleoside kinase
SPSINT_RS01275	COG0561	phosphatase activity
SPSINT_RS01290	COG1136	(ABC) transporter
SPSINT_RS01290	COG0577	efflux transmembrane transporter activity
SPSINT_RS01295	COG1469	GTP cyclohydrolase I activity
SPSINT_RS01300	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SPSINT_RS01315	COG1263	PTS System
SPSINT_RS01315	COG2190	(PTS) system
SPSINT_RS01315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPSINT_RS01330	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
SPSINT_RS01340	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SPSINT_RS01350	COG2814	Major facilitator Superfamily
SPSINT_RS01355	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SPSINT_RS01365	COG0488	(ABC) transporter
SPSINT_RS01370	COG0588	phosphoglycerate mutase activity
SPSINT_RS01375	COG0318	PFAM AMP-dependent synthetase and ligase
SPSINT_RS01380	COG0183	Belongs to the thiolase family
SPSINT_RS01410	COG2363	Small membrane protein
SPSINT_RS01440	COG2311	Membrane
SPSINT_RS01450	COG1566	PFAM secretion protein HlyD family protein
SPSINT_RS01455	COG2814	Major facilitator Superfamily
SPSINT_RS01465	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SPSINT_RS01470	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPSINT_RS01495	COG0095	Lipoate-protein ligase
SPSINT_RS01500	COG0280	phosphate acetyltransferase
SPSINT_RS01525	COG0471	metal ion transport
SPSINT_RS01590	COG4844	belongs to the
SPSINT_RS01600	COG1078	dGTPase activity
SPSINT_RS01615	COG0018	arginyl-trna synthetase
SPSINT_RS01620	COG0805	protein transport
SPSINT_RS01625	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
SPSINT_RS01630	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SPSINT_RS01635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPSINT_RS01640	COG0546	phosphoglycolate phosphatase activity
SPSINT_RS01690	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SPSINT_RS01690	COG2111	Na H antiporter
SPSINT_RS01695	COG2111	Na H antiporter
SPSINT_RS01700	COG1006	Multisubunit Na H antiporter MnhC subunit
SPSINT_RS01710	COG1863	multisubunit Na H antiporter MnhE subunit
SPSINT_RS01715	COG2212	antiporter activity
SPSINT_RS01720	COG1320	monovalent cation:proton antiporter activity
SPSINT_RS01725	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPSINT_RS01730	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPSINT_RS01735	COG1121	(ABC) transporter
SPSINT_RS01745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPSINT_RS01750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPSINT_RS01755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SPSINT_RS01765	COG2423	ornithine cyclodeaminase activity
SPSINT_RS01770	COG4264	IucA IucC family
SPSINT_RS01775	COG2814	Major facilitator Superfamily
SPSINT_RS01780	COG4264	IucA IucC family
SPSINT_RS01785	COG4264	IucA IucC family
SPSINT_RS01795	COG0019	diaminopimelate decarboxylase activity
SPSINT_RS01800	COG1475	DNA binding
SPSINT_RS01810	COG0110	maltose O-acetyltransferase activity
SPSINT_RS01815	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
SPSINT_RS01825	COG1682	transport, permease protein
SPSINT_RS01830	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SPSINT_RS01835	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SPSINT_RS01850	COG1686	Belongs to the peptidase S11 family
SPSINT_RS01855	COG1132	(ABC) transporter
SPSINT_RS01875	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SPSINT_RS01880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPSINT_RS01885	COG1120	ATPase activity
SPSINT_RS01890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPSINT_RS01895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPSINT_RS01905	COG0477	Major facilitator Superfamily
SPSINT_RS01910	COG3949	Membrane
SPSINT_RS01920	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPSINT_RS01925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SPSINT_RS01930	COG0745	RESPONSE REGULATOR receiver
SPSINT_RS01940	COG1136	(ABC) transporter
SPSINT_RS01945	COG0577	efflux transmembrane transporter activity
SPSINT_RS01950	COG1392	Phosphate transport regulator
SPSINT_RS01955	COG0306	phosphate transporter
SPSINT_RS01960	COG1388	LysM domain
SPSINT_RS01960	COG3942	CHAP domain
SPSINT_RS01970	COG0352	thiamine-phosphate diphosphorylase activity
SPSINT_RS01980	COG2022	thiamine diphosphate biosynthetic process
SPSINT_RS01985	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SPSINT_RS01990	COG0217	transcriptional regulatory protein
SPSINT_RS02005	COG0583	DNA-binding transcription factor activity
SPSINT_RS02010	COG2814	Major facilitator Superfamily
SPSINT_RS02015	COG2839	Protein conserved in bacteria
SPSINT_RS02045	COG1611	Belongs to the LOG family
SPSINT_RS02050	COG1671	Belongs to the UPF0178 family
SPSINT_RS02060	COG1968	undecaprenyl-diphosphatase activity
SPSINT_RS02065	COG4988	ABC transporter
SPSINT_RS02070	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SPSINT_RS02080	COG0523	cobalamin synthesis protein
SPSINT_RS02085	COG4989	oxidoreductase activity
SPSINT_RS02110	COG0039	L-malate dehydrogenase activity
SPSINT_RS02135	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SPSINT_RS02135	COG0463	Glycosyl transferase, family 2
SPSINT_RS02140	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SPSINT_RS02160	COG1349	DNA-binding transcription factor activity
SPSINT_RS02165	COG1105	Belongs to the carbohydrate kinase PfkB family
SPSINT_RS02170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPSINT_RS02170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPSINT_RS02170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPSINT_RS02175	COG1253	flavin adenine dinucleotide binding
SPSINT_RS02180	COG0463	Glycosyl transferase, family 2
SPSINT_RS02195	COG0602	queuosine metabolic process
SPSINT_RS02200	COG0720	synthase
SPSINT_RS02210	COG0512	Glutamine amidotransferase of anthranilate synthase
SPSINT_RS02230	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SPSINT_RS02240	COG1368	sulfuric ester hydrolase activity
SPSINT_RS02245	COG0463	Glycosyl transferase, family 2
SPSINT_RS02260	COG2274	protein secretion by the type I secretion system
SPSINT_RS02270	COG0488	(ABC) transporter
SPSINT_RS02275	COG0514	ATP-dependent DNA helicase (RecQ)
SPSINT_RS02280	COG0517	IMP dehydrogenase activity
SPSINT_RS02280	COG1125	glycine betaine transport
SPSINT_RS02285	COG1174	glycine betaine transport
SPSINT_RS02290	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SPSINT_RS02305	COG3104	oligopeptide transport
SPSINT_RS02310	COG3104	oligopeptide transport
SPSINT_RS02340	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPSINT_RS02345	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SPSINT_RS02355	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SPSINT_RS02370	COG3118	belongs to the thioredoxin family
SPSINT_RS02375	COG1929	Belongs to the glycerate kinase type-1 family
SPSINT_RS02380	COG2195	Cleaves the N-terminal amino acid of tripeptides
SPSINT_RS02400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SPSINT_RS02405	COG1739	Uncharacterized protein family UPF0029
SPSINT_RS02415	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SPSINT_RS02430	COG0653	protein targeting
SPSINT_RS02435	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SPSINT_RS02465	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SPSINT_RS02470	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SPSINT_RS02475	COG0110	maltose O-acetyltransferase activity
SPSINT_RS02490	COG1660	Displays ATPase and GTPase activities
SPSINT_RS02495	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SPSINT_RS02500	COG1481	regulation of sporulation
SPSINT_RS02510	COG0740	serine-type endopeptidase activity
SPSINT_RS02540	COG0126	phosphoglycerate kinase activity
SPSINT_RS02545	COG0149	triose-phosphate isomerase activity
SPSINT_RS02550	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SPSINT_RS02555	COG0148	phosphopyruvate hydratase activity
SPSINT_RS02565	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SPSINT_RS02570	COG1647	Serine aminopeptidase, S33
SPSINT_RS02575	COG0557	exoribonuclease II activity
SPSINT_RS02585	COG0582	viral genome integration into host DNA
SPSINT_RS02685	COG0346	lactoylglutathione lyase activity
SPSINT_RS02705	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SPSINT_RS02720	COG1764	response to oxidative stress
SPSINT_RS02730	COG0710	3-dehydroquinate dehydratase activity
SPSINT_RS02740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPSINT_RS02745	COG1393	Belongs to the ArsC family
SPSINT_RS02755	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SPSINT_RS02760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPSINT_RS02770	COG2011	ABC-type metal ion transport system permease component
SPSINT_RS02775	COG1464	Belongs to the NlpA lipoprotein family
SPSINT_RS02780	COG1464	Belongs to the NlpA lipoprotein family
SPSINT_RS02790	COG0396	ATPase activity
SPSINT_RS02795	COG0719	Fe-S assembly protein
SPSINT_RS02805	COG0822	iron-sulfur transferase activity
SPSINT_RS02810	COG0719	Fe-S assembly protein
SPSINT_RS02825	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SPSINT_RS02905	COG1484	DNA-dependent DNA replication
SPSINT_RS03110	COG5632	N-Acetylmuramoyl-L-alanine amidase
SPSINT_RS03110	COG1388	LysM domain
SPSINT_RS03140	COG1253	flavin adenine dinucleotide binding
SPSINT_RS03155	COG1801	Protein of unknown function DUF72
SPSINT_RS03160	COG0730	response to heat
SPSINT_RS03165	COG0737	Belongs to the 5'-nucleotidase family
SPSINT_RS03170	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SPSINT_RS03175	COG4470	Protein conserved in bacteria
SPSINT_RS03185	COG2445	Protein of unknown function DUF86
SPSINT_RS03190	COG0647	UMP catabolic process
SPSINT_RS03195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SPSINT_RS03200	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SPSINT_RS03205	COG4837	Protein of unknown function (DUF1462)
SPSINT_RS03210	COG1252	NADH dehydrogenase
SPSINT_RS03215	COG4844	belongs to the
SPSINT_RS03220	COG0316	Belongs to the HesB IscA family
SPSINT_RS03225	COG1252	NADH dehydrogenase
SPSINT_RS03230	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SPSINT_RS03235	COG2056	Na+-H+ antiporter family
SPSINT_RS03245	COG1320	monovalent cation:proton antiporter activity
SPSINT_RS03250	COG2212	antiporter activity
SPSINT_RS03255	COG1863	multisubunit Na H antiporter MnhE subunit
SPSINT_RS03260	COG0651	ATP synthesis coupled electron transport
SPSINT_RS03265	COG1006	Multisubunit Na H antiporter MnhC subunit
SPSINT_RS03270	COG2111	Na H antiporter
SPSINT_RS03275	COG2111	Na H antiporter
SPSINT_RS03275	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SPSINT_RS03285	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SPSINT_RS03305	COG1278	Cold shock
SPSINT_RS03315	COG1098	S1 RNA binding domain
SPSINT_RS03320	COG1012	belongs to the aldehyde dehydrogenase family
SPSINT_RS03340	COG0584	glycerophosphoryl diester phosphodiesterase
SPSINT_RS03350	COG0137	argininosuccinate synthase activity
SPSINT_RS03355	COG0166	Belongs to the GPI family
SPSINT_RS03370	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SPSINT_RS03380	COG0179	Fumarylacetoacetate (FAA) hydrolase
SPSINT_RS03390	COG3344	reverse transcriptase
SPSINT_RS03395	COG0446	pyridine nucleotide-disulphide oxidoreductase
SPSINT_RS03400	COG0561	phosphatase activity
SPSINT_RS03420	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
SPSINT_RS03445	COG0601	transmembrane transport
SPSINT_RS03450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPSINT_RS03455	COG0444	Belongs to the ABC transporter superfamily
SPSINT_RS03460	COG4608	Belongs to the ABC transporter superfamily
SPSINT_RS03465	COG4166	transmembrane transport
SPSINT_RS03470	COG0180	Tryptophanyl-tRNA synthetase
SPSINT_RS03475	COG1393	Belongs to the ArsC family
SPSINT_RS03500	COG1164	Oligoendopeptidase f
SPSINT_RS03510	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SPSINT_RS03515	COG2346	COG2346, Truncated hemoglobins
SPSINT_RS03530	COG2357	RelA SpoT domain protein
SPSINT_RS03540	COG0564	pseudouridine synthase activity
SPSINT_RS03545	COG2239	Acts as a magnesium transporter
SPSINT_RS03550	COG0475	glutathione-regulated potassium exporter activity
SPSINT_RS03550	COG0569	domain protein
SPSINT_RS03560	COG0673	inositol 2-dehydrogenase activity
SPSINT_RS03565	COG2211	Major facilitator Superfamily
SPSINT_RS03570	COG4409	exo-alpha-(2->6)-sialidase activity
SPSINT_RS03575	COG0628	permease
SPSINT_RS03580	COG1115	amino acid carrier protein
SPSINT_RS03585	COG2382	esterase
SPSINT_RS03590	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SPSINT_RS03615	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SPSINT_RS03650	COG3716	PTS system mannose fructose sorbose family IID component
SPSINT_RS03655	COG3715	PTS system
SPSINT_RS03665	COG2814	Major facilitator Superfamily
SPSINT_RS03670	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SPSINT_RS03680	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SPSINT_RS03690	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SPSINT_RS03695	COG0861	Integral membrane protein TerC family
SPSINT_RS03700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPSINT_RS03705	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPSINT_RS03720	COG1696	Membrane protein involved in D-alanine export
SPSINT_RS03725	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SPSINT_RS03735	COG0737	Belongs to the 5'-nucleotidase family
SPSINT_RS03740	COG4932	domain protein
SPSINT_RS03740	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
SPSINT_RS03740	COG3266	domain, Protein
SPSINT_RS03770	COG4873	Protein conserved in bacteria
SPSINT_RS03790	COG4619	ABC transporter
SPSINT_RS03795	COG0390	transport system, permease component
SPSINT_RS03800	COG1575	Belongs to the MenA family. Type 1 subfamily
SPSINT_RS03805	COG1169	isochorismate synthase
SPSINT_RS03810	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SPSINT_RS03820	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SPSINT_RS03825	COG0436	Aminotransferase
SPSINT_RS03830	COG3594	Acyltransferase
SPSINT_RS03855	COG1316	TRANSCRIPTIONal
SPSINT_RS03860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPSINT_RS03865	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
SPSINT_RS03875	COG1215	transferase activity, transferring glycosyl groups
SPSINT_RS03885	COG1682	transport, permease protein
SPSINT_RS03895	COG1134	teichoic acid transport
SPSINT_RS03910	COG3212	peptidase
SPSINT_RS03920	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
SPSINT_RS03925	COG1845	cytochrome c oxidase, subunit III
SPSINT_RS03935	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SPSINT_RS03945	COG1017	nitric oxide dioxygenase activity
SPSINT_RS03945	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SPSINT_RS03950	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SPSINT_RS03955	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SPSINT_RS03960	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SPSINT_RS03965	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SPSINT_RS03970	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SPSINT_RS03975	COG0047	phosphoribosylformylglycinamidine synthase activity
SPSINT_RS03985	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
SPSINT_RS03990	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SPSINT_RS04000	COG0138	bifunctional purine biosynthesis protein purh
SPSINT_RS04005	COG0151	Belongs to the GarS family
SPSINT_RS04015	COG4172	Belongs to the ABC transporter superfamily
SPSINT_RS04030	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SPSINT_RS04040	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPSINT_RS04045	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SPSINT_RS04055	COG1393	Belongs to the ArsC family
SPSINT_RS04060	COG1271	oxidase subunit
SPSINT_RS04065	COG1294	oxidase, subunit
SPSINT_RS04070	COG0569	domain protein
SPSINT_RS04080	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SPSINT_RS04085	COG5503	Protein of unknown function (DUF1447)
SPSINT_RS04125	COG4476	Belongs to the UPF0223 family
SPSINT_RS04135	COG3842	ATPase activity
SPSINT_RS04145	COG1177	transmembrane transport
SPSINT_RS04150	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
SPSINT_RS04165	COG4493	Belongs to the UPF0637 family
SPSINT_RS04170	COG0483	inositol monophosphate 1-phosphatase activity
SPSINT_RS04180	COG1217	gtp-binding protein TYPA
SPSINT_RS04185	COG1902	pentaerythritol trinitrate reductase activity
SPSINT_RS04190	COG4896	Protein conserved in bacteria
SPSINT_RS04195	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SPSINT_RS04200	COG4838	Belongs to the UPF0358 family
SPSINT_RS04205	COG0772	Belongs to the SEDS family
SPSINT_RS04220	COG0109	protoheme IX farnesyltransferase activity
SPSINT_RS04235	COG3679	Belongs to the UPF0342 family
SPSINT_RS04240	COG0584	glycerophosphoryl diester phosphodiesterase
SPSINT_RS04245	COG4471	UPF0298 protein
SPSINT_RS04255	COG0742	ribosomal rna small subunit methyltransferase
SPSINT_RS04275	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SPSINT_RS04280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SPSINT_RS04285	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SPSINT_RS04300	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SPSINT_RS04315	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SPSINT_RS04315	COG1796	DNA polymerase
SPSINT_RS04320	COG1193	negative regulation of DNA recombination
SPSINT_RS04325	COG3118	belongs to the thioredoxin family
SPSINT_RS04330	COG0322	excinuclease ABC activity
SPSINT_RS04335	COG2009	succinate dehydrogenase
SPSINT_RS04340	COG1053	succinate dehydrogenase
SPSINT_RS04345	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SPSINT_RS04350	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SPSINT_RS04390	COG0783	Belongs to the Dps family
SPSINT_RS04395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPSINT_RS04440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SPSINT_RS04450	COG1011	Hydrolase
SPSINT_RS04455	COG0454	-acetyltransferase
SPSINT_RS04460	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
SPSINT_RS04465	COG2001	Belongs to the MraZ family
SPSINT_RS04470	COG0275	rRNA processing
SPSINT_RS04475	COG4839	cell division protein FtsL
SPSINT_RS04480	COG0768	penicillin binding
SPSINT_RS04490	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SPSINT_RS04500	COG0849	cell division
SPSINT_RS04505	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SPSINT_RS04515	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SPSINT_RS04520	COG1799	cell septum assembly
SPSINT_RS04525	COG0762	integral membrane protein
SPSINT_RS04530	COG1869	D-ribose catabolic process
SPSINT_RS04535	COG4975	Glucose uptake
SPSINT_RS04545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPSINT_RS04550	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPSINT_RS04570	COG3599	regulation of cell shape
SPSINT_RS04575	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SPSINT_RS04580	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SPSINT_RS04585	COG0564	pseudouridine synthase activity
SPSINT_RS04590	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SPSINT_RS04610	COG0505	Belongs to the CarA family
SPSINT_RS04615	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SPSINT_RS04625	COG0167	dihydroorotate dehydrogenase activity
SPSINT_RS04630	COG0284	orotidine-5'-phosphate decarboxylase activity
SPSINT_RS04635	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SPSINT_RS04655	COG1758	RNA polymerase activity
SPSINT_RS04680	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SPSINT_RS04685	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SPSINT_RS04690	COG0242	peptide deformylase activity
SPSINT_RS04695	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SPSINT_RS04700	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SPSINT_RS04700	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SPSINT_RS04705	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SPSINT_RS04720	COG2124	cytochrome p450
SPSINT_RS04730	COG1162	GTPase activity
SPSINT_RS04735	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SPSINT_RS04750	COG1302	Protein conserved in bacteria
SPSINT_RS04760	COG1760	l-serine dehydratase
SPSINT_RS04765	COG1760	l-serine dehydratase
SPSINT_RS04775	COG1349	DNA-binding transcription factor activity
SPSINT_RS04780	COG0416	fatty acid biosynthetic process
SPSINT_RS04795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SPSINT_RS04800	COG0571	ribonuclease III activity
SPSINT_RS04805	COG1196	nuclear chromosome segregation
SPSINT_RS04810	COG0552	protein localization to endoplasmic reticulum
SPSINT_RS04815	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
SPSINT_RS04820	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SPSINT_RS04885	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SPSINT_RS04895	COG0228	four-way junction DNA binding
SPSINT_RS04900	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SPSINT_RS04905	COG0336	Belongs to the RNA methyltransferase TrmD family
SPSINT_RS04945	COG4485	Bacterial membrane protein, YfhO
SPSINT_RS04960	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SPSINT_RS04970	COG0045	succinate-CoA ligase (ADP-forming) activity
SPSINT_RS04980	COG0758	DNA mediated transformation
SPSINT_RS04985	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SPSINT_RS04990	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SPSINT_RS04995	COG4974	Belongs to the 'phage' integrase family
SPSINT_RS05000	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SPSINT_RS05005	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SPSINT_RS05010	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SPSINT_RS05015	COG0052	Belongs to the universal ribosomal protein uS2 family
SPSINT_RS05020	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SPSINT_RS05025	COG0528	UMP kinase activity
SPSINT_RS05030	COG0233	cytoplasmic translational termination
SPSINT_RS05040	COG4589	Belongs to the CDS family
SPSINT_RS05045	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
SPSINT_RS05055	COG0442	prolyl-tRNA aminoacylation
SPSINT_RS05065	COG0779	Required for maturation of 30S ribosomal subunits
SPSINT_RS05070	COG0195	Participates in both transcription termination and antitermination
SPSINT_RS05075	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SPSINT_RS05080	COG1358	cellular component organization or biogenesis
SPSINT_RS05085	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SPSINT_RS05095	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SPSINT_RS05100	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SPSINT_RS05105	COG0196	riboflavin kinase activity
SPSINT_RS05115	COG1185	polyribonucleotide nucleotidyltransferase activity
SPSINT_RS05130	COG2188	Transcriptional regulator
SPSINT_RS05135	COG0612	Peptidase, M16
SPSINT_RS05140	COG0612	Peptidase, M16
SPSINT_RS05145	COG0300	oxidoreductase activity
SPSINT_RS05165	COG1546	Belongs to the CinA family
SPSINT_RS05165	COG1058	Belongs to the CinA family
SPSINT_RS05170	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SPSINT_RS05175	COG1418	mRNA catabolic process
SPSINT_RS05195	COG1692	metallophosphoesterase
SPSINT_RS05200	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SPSINT_RS05200	COG0674	pyruvate-flavodoxin oxidoreductase activity
SPSINT_RS05205	COG1013	pyruvate-flavodoxin oxidoreductase activity
SPSINT_RS05215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SPSINT_RS05235	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SPSINT_RS05240	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
SPSINT_RS05245	COG1619	proteins homologs of microcin C7 resistance protein MccF
SPSINT_RS05250	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SPSINT_RS05260	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SPSINT_RS05265	COG1923	regulation of RNA biosynthetic process
SPSINT_RS05270	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SPSINT_RS05275	COG2267	carboxylic ester hydrolase activity
SPSINT_RS05280	COG0386	Belongs to the glutathione peroxidase family
SPSINT_RS05285	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SPSINT_RS05290	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SPSINT_RS05295	COG0789	Transcriptional regulator
SPSINT_RS05305	COG4974	Belongs to the 'phage' integrase family
SPSINT_RS05320	COG0584	glycerophosphoryl diester phosphodiesterase
SPSINT_RS05350	COG1525	nuclease
SPSINT_RS05370	COG0527	aspartate kinase activity
SPSINT_RS05375	COG0460	homoserine dehydrogenase
SPSINT_RS05380	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SPSINT_RS05385	COG0083	homoserine kinase activity
SPSINT_RS05400	COG0833	amino acid
SPSINT_RS05410	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SPSINT_RS05415	COG0516	GMP reductase activity
SPSINT_RS05425	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SPSINT_RS05435	COG4224	UPF0291 protein
SPSINT_RS05445	COG3763	UPF0154 protein
SPSINT_RS05450	COG4846	Membrane protein involved in cytochrome C biogenesis
SPSINT_RS05455	COG0420	3'-5' exonuclease activity
SPSINT_RS05460	COG0419	ATPase involved in DNA repair
SPSINT_RS05465	COG1970	mechanosensitive ion channel activity
SPSINT_RS05470	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SPSINT_RS05480	COG0824	Thioesterase
SPSINT_RS05485	COG4841	protein insertion into membrane
SPSINT_RS05490	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SPSINT_RS05500	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SPSINT_RS05505	COG1115	amino acid carrier protein
SPSINT_RS05510	COG3711	transcriptional antiterminator
SPSINT_RS05520	COG0628	permease
SPSINT_RS05550	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SPSINT_RS05555	COG0287	Prephenate dehydrogenase
SPSINT_RS05560	COG1363	Peptidase, m42
SPSINT_RS05590	COG2996	Protein conserved in bacteria
SPSINT_RS05595	COG0488	(ABC) transporter
SPSINT_RS05600	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SPSINT_RS05605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SPSINT_RS05610	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SPSINT_RS05615	COG2171	N-acyltransferase activity
SPSINT_RS05620	COG1473	amidohydrolase
SPSINT_RS05640	COG1278	Cold shock
SPSINT_RS05660	COG3853	Toxic anion resistance protein (TelA)
SPSINT_RS05665	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SPSINT_RS05670	COG1114	Component of the transport system for branched-chain amino acids
SPSINT_RS05675	COG4548	von Willebrand factor, type A
SPSINT_RS05680	COG0714	Associated with various cellular activities
SPSINT_RS05705	COG0567	Dehydrogenase, E1 component
SPSINT_RS05710	COG5002	protein histidine kinase activity
SPSINT_RS05720	COG0671	phosphoesterase, PA-phosphatase related
SPSINT_RS05725	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SPSINT_RS05735	COG0793	Belongs to the peptidase S41A family
SPSINT_RS05745	COG2190	(PTS) system
SPSINT_RS05780	COG1413	lyase activity
SPSINT_RS05790	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SPSINT_RS05800	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPSINT_RS05805	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SPSINT_RS05810	COG2962	Rard protein
SPSINT_RS05815	COG0116	Belongs to the methyltransferase superfamily
SPSINT_RS05820	COG3599	regulation of cell shape
SPSINT_RS05825	COG4474	Belongs to the UPF0398 family
SPSINT_RS05840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPSINT_RS05840	COG4499	WXG100 protein secretion system (Wss), protein YukC
SPSINT_RS05850	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SPSINT_RS05855	COG3935	DnaD domain protein
SPSINT_RS05860	COG0017	Asparaginyl-tRNA synthetase
SPSINT_RS05875	COG0617	tRNA 3'-terminal CCA addition
SPSINT_RS05880	COG0438	transferase activity, transferring glycosyl groups
SPSINT_RS05885	COG1694	Mazg nucleotide pyrophosphohydrolase
SPSINT_RS05895	COG4347	Protein of unknown function (DUF1405)
SPSINT_RS05900	COG5582	Belongs to the UPF0302 family
SPSINT_RS05905	COG0457	Tetratricopeptide repeat
SPSINT_RS05915	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SPSINT_RS05925	COG0105	UTP biosynthetic process
SPSINT_RS05930	COG0142	geranyltranstransferase activity
SPSINT_RS05950	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SPSINT_RS05955	COG1160	GTP binding
SPSINT_RS05960	COG0539	negative regulation of cytoplasmic translation
SPSINT_RS05970	COG0252	asparaginase activity
SPSINT_RS05975	COG0492	ferredoxin-NADP+ reductase activity
SPSINT_RS05985	COG0514	ATP-dependent DNA helicase (RecQ)
SPSINT_RS05995	COG1141	Ferredoxin
SPSINT_RS06010	COG0745	RESPONSE REGULATOR receiver
SPSINT_RS06015	COG1187	pseudouridine synthase activity
SPSINT_RS06020	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SPSINT_RS06025	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SPSINT_RS06040	COG0735	belongs to the Fur family
SPSINT_RS06045	COG0494	nUDIX hydrolase
SPSINT_RS06050	COG0667	Aldo Keto reductase
SPSINT_RS06060	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SPSINT_RS06065	COG1234	tRNA 3'-trailer cleavage
SPSINT_RS06070	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SPSINT_RS06100	COG2195	Cleaves the N-terminal amino acid of tripeptides
SPSINT_RS06105	COG4129	membrane
SPSINT_RS06115	COG0508	dehydrogenase complex catalyzes the overall conversion of
SPSINT_RS06120	COG0022	dehydrogenase e1 component
SPSINT_RS06125	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SPSINT_RS06130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPSINT_RS06135	COG3426	butyrate kinase activity
SPSINT_RS06140	COG0280	phosphate acetyltransferase
SPSINT_RS06145	COG0497	DNA recombination
SPSINT_RS06150	COG1438	arginine binding
SPSINT_RS06155	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SPSINT_RS06165	COG1722	exodeoxyribonuclease VII activity
SPSINT_RS06170	COG1570	exodeoxyribonuclease VII activity
SPSINT_RS06180	COG1302	Protein conserved in bacteria
SPSINT_RS06185	COG0439	Biotin carboxylase
SPSINT_RS06190	COG0511	ligase activity, forming carbon-carbon bonds
SPSINT_RS06195	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SPSINT_RS06200	COG0006	proline dipeptidase activity
SPSINT_RS06215	COG0095	Lipoate-protein ligase
SPSINT_RS06220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPSINT_RS06225	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SPSINT_RS06235	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SPSINT_RS06240	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SPSINT_RS06275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPSINT_RS06280	COG1475	DNA binding
SPSINT_RS06285	COG3969	phosphoadenosine phosphosulfate
SPSINT_RS06315	COG4824	toxin secretion phage lysis holin
SPSINT_RS06410	COG0740	serine-type endopeptidase activity
SPSINT_RS06585	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SPSINT_RS06590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SPSINT_RS06595	COG0011	TIGRFAM Protein of
SPSINT_RS06600	COG1940	carbohydrate kinase activity
SPSINT_RS06605	COG4483	Protein conserved in bacteria
SPSINT_RS06610	COG0457	Tetratricopeptide repeat
SPSINT_RS06610	COG0705	Rhomboid family
SPSINT_RS06615	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SPSINT_RS06625	COG0704	Plays a role in the regulation of phosphate uptake
SPSINT_RS06630	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SPSINT_RS06635	COG0581	inorganic phosphate transmembrane transporter activity
SPSINT_RS06640	COG0573	inorganic phosphate transmembrane transporter activity
SPSINT_RS06645	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SPSINT_RS06650	COG0768	penicillin binding
SPSINT_RS06660	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
SPSINT_RS06670	COG0735	belongs to the Fur family
SPSINT_RS06675	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SPSINT_RS06680	COG1121	(ABC) transporter
SPSINT_RS06685	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SPSINT_RS06690	COG0513	Belongs to the DEAD box helicase family
SPSINT_RS06695	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
SPSINT_RS06700	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SPSINT_RS06705	COG2384	SAM-dependent methyltransferase
SPSINT_RS06710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SPSINT_RS06715	COG0358	DNA primase activity
SPSINT_RS06720	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SPSINT_RS06725	COG0517	IMP dehydrogenase activity
SPSINT_RS06730	COG0423	glycine-tRNA ligase activity
SPSINT_RS06735	COG1381	Involved in DNA repair and RecF pathway recombination
SPSINT_RS06740	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SPSINT_RS06750	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
SPSINT_RS06760	COG1702	phosphate starvation-inducible protein PhoH
SPSINT_RS06770	COG4864	UPF0365 protein
SPSINT_RS06775	COG1030	water channel activity
SPSINT_RS06790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SPSINT_RS06795	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SPSINT_RS06800	COG2264	protein methyltransferase activity
SPSINT_RS06805	COG0484	heat shock protein binding
SPSINT_RS06810	COG0443	Heat shock 70 kDa protein
SPSINT_RS06825	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SPSINT_RS06835	COG0268	Binds directly to 16S ribosomal RNA
SPSINT_RS06840	COG1466	dna polymerase III delta subunit
SPSINT_RS06845	COG2333	competence protein COMEC
SPSINT_RS06845	COG0658	competence protein
SPSINT_RS06850	COG2131	deaminase
SPSINT_RS06855	COG1555	photosystem II stabilization
SPSINT_RS06855	COG1596	polysaccharide export
SPSINT_RS06860	COG2226	methyltransferase
SPSINT_RS06865	COG0799	negative regulation of ribosome biogenesis
SPSINT_RS06870	COG1713	HD superfamily hydrolase involved in NAD metabolism
SPSINT_RS06880	COG1534	Rna-binding protein
SPSINT_RS06885	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SPSINT_RS06890	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SPSINT_RS06895	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SPSINT_RS06900	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SPSINT_RS06905	COG1914	H( )-stimulated, divalent metal cation uptake system
SPSINT_RS06910	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SPSINT_RS06915	COG0439	Biotin carboxylase
SPSINT_RS06920	COG0511	ligase activity, forming carbon-carbon bonds
SPSINT_RS06925	COG1984	allophanate hydrolase subunit 2
SPSINT_RS06930	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SPSINT_RS06940	COG0572	uridine kinase
SPSINT_RS06945	COG0826	peptidase U32
SPSINT_RS06950	COG0826	peptidase U32
SPSINT_RS06955	COG4122	O-methyltransferase activity
SPSINT_RS06960	COG3906	Belongs to the UPF0473 family
SPSINT_RS06965	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SPSINT_RS06970	COG4472	Bacterial protein of unknown function (DUF965)
SPSINT_RS06975	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SPSINT_RS06980	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SPSINT_RS06990	COG0482	sulfurtransferase activity
SPSINT_RS06995	COG1104	cysteine desulfurase activity
SPSINT_RS07000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPSINT_RS07015	COG1959	2 iron, 2 sulfur cluster binding
SPSINT_RS07020	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SPSINT_RS07025	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SPSINT_RS07030	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SPSINT_RS07040	COG0860	N-Acetylmuramoyl-L-alanine amidase
SPSINT_RS07045	COG1490	D-aminoacyl-tRNA deacylase activity
SPSINT_RS07055	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SPSINT_RS07060	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SPSINT_RS07060	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SPSINT_RS07065	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SPSINT_RS07065	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SPSINT_RS07070	COG1862	Preprotein translocase
SPSINT_RS07080	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SPSINT_RS07085	COG2255	four-way junction helicase activity
SPSINT_RS07090	COG0632	four-way junction helicase activity
SPSINT_RS07100	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SPSINT_RS07110	COG2868	ribosomal protein
SPSINT_RS07140	COG2003	Belongs to the UPF0758 family
SPSINT_RS07150	COG0285	dihydrofolate synthase activity
SPSINT_RS07155	COG0525	valine-tRNA ligase activity
SPSINT_RS07160	COG2818	Glycosylase
SPSINT_RS07170	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SPSINT_RS07185	COG0181	hydroxymethylbilane synthase activity
SPSINT_RS07195	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SPSINT_RS07200	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SPSINT_RS07215	COG0544	peptidyl-prolyl cis-trans isomerase activity
SPSINT_RS07230	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SPSINT_RS07235	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SPSINT_RS07240	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SPSINT_RS07245	COG0833	amino acid
SPSINT_RS07255	COG1484	DNA-dependent DNA replication
SPSINT_RS07260	COG3611	Membrane attachment protein
SPSINT_RS07275	COG0237	dephospho-CoA kinase activity
SPSINT_RS07285	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPSINT_RS07285	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SPSINT_RS07290	COG5002	protein histidine kinase activity
SPSINT_RS07295	COG0745	RESPONSE REGULATOR receiver
SPSINT_RS07300	COG0538	isocitrate dehydrogenase activity
SPSINT_RS07305	COG0372	Belongs to the citrate synthase family
SPSINT_RS07310	COG0469	pyruvate kinase activity
SPSINT_RS07315	COG0205	6-phosphofructokinase activity
SPSINT_RS07320	COG0825	malonyl-CoA metabolic process
SPSINT_RS07325	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SPSINT_RS07330	COG0281	malic enzyme
SPSINT_RS07335	COG0587	DNA-directed DNA polymerase activity
SPSINT_RS07340	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SPSINT_RS07345	COG4109	DRTGG domain
SPSINT_RS07355	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SPSINT_RS07360	COG0006	proline dipeptidase activity
SPSINT_RS07370	COG0686	Belongs to the AlaDH PNT family
SPSINT_RS07375	COG0589	response to stress
SPSINT_RS07380	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SPSINT_RS07385	COG0827	DNA restriction-modification system
SPSINT_RS07390	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SPSINT_RS07395	COG1714	RDD family
SPSINT_RS07400	COG0616	signal peptide processing
SPSINT_RS07410	COG0301	tRNA thio-modification
SPSINT_RS07415	COG1104	cysteine desulfurase activity
SPSINT_RS07420	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
SPSINT_RS07425	COG1956	GAF domain-containing protein
SPSINT_RS07430	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SPSINT_RS07460	COG0456	acetyltransferase
SPSINT_RS07495	COG1764	response to oxidative stress
SPSINT_RS07500	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SPSINT_RS07505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SPSINT_RS07515	COG0204	Acyl-transferase
SPSINT_RS07520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SPSINT_RS07530	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
SPSINT_RS07535	COG2759	Belongs to the formate--tetrahydrofolate ligase family
SPSINT_RS07540	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SPSINT_RS07545	COG0454	-acetyltransferase
SPSINT_RS07555	COG1609	Transcriptional regulator
SPSINT_RS07560	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SPSINT_RS07560	COG1605	Chorismate mutase
SPSINT_RS07570	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
SPSINT_RS07575	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SPSINT_RS07580	COG1674	ftsk spoiiie
SPSINT_RS07585	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SPSINT_RS07590	COG4848	Belongs to the UPF0354 family
SPSINT_RS07595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPSINT_RS07600	COG1363	Peptidase, m42
SPSINT_RS07610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SPSINT_RS07615	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SPSINT_RS07620	COG0510	thiamine kinase activity
SPSINT_RS07625	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SPSINT_RS07630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPSINT_RS07640	COG1187	pseudouridine synthase activity
SPSINT_RS07645	COG2244	polysaccharide biosynthetic process
SPSINT_RS07650	COG2081	HI0933 family
SPSINT_RS07655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SPSINT_RS07660	COG0495	leucyl-tRNA aminoacylation
SPSINT_RS07665	COG2814	Major facilitator Superfamily
SPSINT_RS07670	COG1242	4 iron, 4 sulfur cluster binding
SPSINT_RS07675	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SPSINT_RS07685	COG0039	L-malate dehydrogenase activity
SPSINT_RS07690	COG2267	carboxylic ester hydrolase activity
SPSINT_RS07705	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SPSINT_RS07710	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPSINT_RS07710	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SPSINT_RS07715	COG0307	riboflavin synthase, alpha
SPSINT_RS07720	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SPSINT_RS07720	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SPSINT_RS07730	COG3266	domain, Protein
SPSINT_RS07730	COG5632	N-Acetylmuramoyl-L-alanine amidase
SPSINT_RS07730	COG4193	domain, Protein
SPSINT_RS07755	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SPSINT_RS07765	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPSINT_RS07770	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SPSINT_RS07775	COG0656	L-ascorbic acid biosynthetic process
SPSINT_RS07785	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SPSINT_RS07790	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SPSINT_RS07795	COG1506	peptidase
SPSINT_RS07800	COG0494	nUDIX hydrolase
SPSINT_RS07805	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SPSINT_RS07825	COG0235	Class ii aldolase
SPSINT_RS07830	COG3623	hexulose-6-phosphate isomerase
SPSINT_RS07850	COG3037	sugar-specific permease SgaT UlaA
SPSINT_RS07935	COG3545	Serine hydrolase
SPSINT_RS07940	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SPSINT_RS07950	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SPSINT_RS07960	COG4473	ABC transporter
SPSINT_RS07965	COG1131	(ABC) transporter
SPSINT_RS07970	COG0537	adenosine 5'-monophosphoramidase activity
SPSINT_RS07980	COG1846	Transcriptional regulator
SPSINT_RS07990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SPSINT_RS07995	COG3481	metal-dependent phosphohydrolase, HD sub domain
SPSINT_RS08005	COG0420	3'-5' exonuclease activity
SPSINT_RS08010	COG3679	Belongs to the UPF0342 family
SPSINT_RS08015	COG4399	Belongs to the UPF0754 family
SPSINT_RS08030	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SPSINT_RS08035	COG2197	response regulator
SPSINT_RS08040	COG2203	Gaf domain
SPSINT_RS08040	COG4585	Histidine kinase
SPSINT_RS08045	COG0564	pseudouridine synthase activity
SPSINT_RS08050	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SPSINT_RS08055	COG0248	Ppx GppA phosphatase
SPSINT_RS08060	COG0114	fumarate hydratase activity
SPSINT_RS08070	COG0363	glucosamine-6-phosphate deaminase activity
SPSINT_RS08080	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SPSINT_RS08085	COG1126	abc transporter atp-binding protein
SPSINT_RS08090	COG0765	amino acid transport
SPSINT_RS08255	COG0735	belongs to the Fur family
SPSINT_RS08265	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SPSINT_RS08270	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SPSINT_RS08275	COG4129	membrane
SPSINT_RS08280	COG0069	glutamate synthase activity
SPSINT_RS08290	COG3557	Belongs to the UPF0374 family
SPSINT_RS08295	COG1194	a g-specific adenine glycosylase
SPSINT_RS08300	COG1988	membrane-bound metal-dependent
SPSINT_RS08310	COG1134	teichoic acid transport
SPSINT_RS08310	COG1388	LysM domain
SPSINT_RS08320	COG2137	regulation of response to DNA damage stimulus
SPSINT_RS08325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SPSINT_RS08330	COG0028	Belongs to the TPP enzyme family
SPSINT_RS08335	COG0693	protein deglycase activity
SPSINT_RS08340	COG0535	radical SAM domain protein
SPSINT_RS08345	COG1607	acyl-coa hydrolase
SPSINT_RS08350	COG2309	aminopeptidase activity
SPSINT_RS08355	COG4840	Belongs to the UPF0435 family
SPSINT_RS08370	COG1295	ribonuclease BN
SPSINT_RS08375	COG0288	reversible hydration of carbon dioxide
SPSINT_RS08400	COG0024	Methionine aminopeptidase
SPSINT_RS08405	COG4129	membrane
SPSINT_RS08420	COG1528	Iron-storage protein
SPSINT_RS08435	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SPSINT_RS08445	COG2211	Major facilitator Superfamily
SPSINT_RS08450	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SPSINT_RS08460	COG1597	lipid kinase activity
SPSINT_RS08465	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SPSINT_RS08475	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SPSINT_RS08480	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPSINT_RS08485	COG4851	CamS sex pheromone cAM373 precursor
SPSINT_RS08490	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SPSINT_RS08495	COG0210	DNA helicase
SPSINT_RS08500	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
SPSINT_RS08505	COG4496	protein, YerC YecD
SPSINT_RS08510	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SPSINT_RS08520	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
SPSINT_RS08530	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SPSINT_RS08540	COG0077	Prephenate dehydratase
SPSINT_RS08540	COG1605	Chorismate mutase
SPSINT_RS08550	COG1335	isochorismatase
SPSINT_RS08555	COG1227	inorganic diphosphatase activity
SPSINT_RS08565	COG1012	belongs to the aldehyde dehydrogenase family
SPSINT_RS08570	COG2706	6-phosphogluconolactonase activity
SPSINT_RS08600	COG2610	gluconate transmembrane transporter activity
SPSINT_RS08605	COG1070	Carbohydrate kinase
SPSINT_RS08620	COG1131	(ABC) transporter
SPSINT_RS08640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SPSINT_RS08645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPSINT_RS08650	COG1404	Belongs to the peptidase S8 family
SPSINT_RS08690	COG4512	PFAM Accessory gene regulator B
SPSINT_RS08710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SPSINT_RS08715	COG1621	beta-fructofuranosidase activity
SPSINT_RS08720	COG1609	Transcriptional regulator
SPSINT_RS08725	COG2124	cytochrome p450
SPSINT_RS08735	COG1846	Transcriptional regulator
SPSINT_RS08740	COG2814	Major facilitator Superfamily
SPSINT_RS08745	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SPSINT_RS08750	COG0488	(ABC) transporter
SPSINT_RS08755	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SPSINT_RS08760	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SPSINT_RS08765	COG0456	acetyltransferase
SPSINT_RS08770	COG1214	PFAM Peptidase M22, glycoprotease
SPSINT_RS08775	COG0802	atpase or kinase
SPSINT_RS08780	COG0129	dihydroxy-acid dehydratase activity
SPSINT_RS08785	COG0028	Belongs to the TPP enzyme family
SPSINT_RS08795	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SPSINT_RS08800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SPSINT_RS08810	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SPSINT_RS08855	COG3091	SprT-like family
SPSINT_RS08860	COG2183	response to ionizing radiation
SPSINT_RS08865	COG1191	sigma factor activity
SPSINT_RS08875	COG1366	Belongs to the anti-sigma-factor antagonist family
SPSINT_RS08880	COG2208	phosphoserine phosphatase activity
SPSINT_RS08885	COG2337	Toxic component of a toxin-antitoxin (TA) module
SPSINT_RS08895	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SPSINT_RS08900	COG0736	holo-[acyl-carrier-protein] synthase activity
SPSINT_RS08905	COG3402	PFAM membrane-flanked domain
SPSINT_RS08920	COG0513	Belongs to the DEAD box helicase family
SPSINT_RS08925	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SPSINT_RS08930	COG1181	Belongs to the D-alanine--D-alanine ligase family
SPSINT_RS08935	COG0772	Belongs to the SEDS family
SPSINT_RS08950	COG2217	Heavy metal translocating P-type atpase
SPSINT_RS08965	COG1937	Protein conserved in bacteria
SPSINT_RS08970	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
SPSINT_RS08975	COG1418	mRNA catabolic process
SPSINT_RS08980	COG0706	membrane insertase activity
SPSINT_RS08985	COG0352	thiamine-phosphate diphosphorylase activity
SPSINT_RS08990	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SPSINT_RS09000	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SPSINT_RS09015	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SPSINT_RS09045	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SPSINT_RS09055	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPSINT_RS09065	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SPSINT_RS09070	COG0356	it plays a direct role in the translocation of protons across the membrane
SPSINT_RS09080	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SPSINT_RS09085	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SPSINT_RS09095	COG4475	Protein of unknown function (DUF436)
SPSINT_RS09100	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SPSINT_RS09105	COG0009	L-threonylcarbamoyladenylate synthase
SPSINT_RS09110	COG2890	protein-(glutamine-N5) methyltransferase activity
SPSINT_RS09115	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SPSINT_RS09125	COG0254	rRNA binding
SPSINT_RS09130	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SPSINT_RS09140	COG1733	regulation of RNA biosynthetic process
SPSINT_RS09145	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SPSINT_RS09150	COG0191	fructose-bisphosphate aldolase activity
SPSINT_RS09155	COG4821	SIS domain
SPSINT_RS09160	COG2271	Major facilitator Superfamily
SPSINT_RS09165	COG0504	CTP synthase activity
SPSINT_RS09170	COG3343	RNA polymerase activity
SPSINT_RS09175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SPSINT_RS09185	COG5146	pantothenate kinase activity
SPSINT_RS09220	COG0813	purine-nucleoside phosphorylase activity
SPSINT_RS09230	COG1757	Na H antiporter
SPSINT_RS09245	COG1482	cell wall glycoprotein biosynthetic process
SPSINT_RS09250	COG2186	Transcriptional regulator
SPSINT_RS09260	COG0561	phosphatase activity
SPSINT_RS09265	COG1119	ATPase activity
SPSINT_RS09285	COG3711	transcriptional antiterminator
SPSINT_RS09300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SPSINT_RS09365	COG0489	protein tyrosine kinase activity
SPSINT_RS09370	COG2814	Major facilitator Superfamily
SPSINT_RS09390	COG1272	protein, Hemolysin III
SPSINT_RS09395	COG4284	Utp--glucose-1-phosphate uridylyltransferase
SPSINT_RS09400	COG1988	membrane-bound metal-dependent
SPSINT_RS09410	COG3314	Sporulation integral membrane protein YlbJ
SPSINT_RS09415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPSINT_RS09420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SPSINT_RS09425	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
SPSINT_RS09430	COG3457	Alanine racemase
SPSINT_RS09435	COG4264	IucA IucC family
SPSINT_RS09440	COG2814	Major facilitator Superfamily
SPSINT_RS09445	COG4264	IucA IucC family
SPSINT_RS09450	COG2814	Major facilitator Superfamily
SPSINT_RS09455	COG1302	Protein conserved in bacteria
SPSINT_RS09470	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SPSINT_RS09480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SPSINT_RS09485	COG0488	(ABC) transporter
SPSINT_RS09490	COG2723	6-phospho-beta-galactosidase activity
SPSINT_RS09495	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPSINT_RS09495	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SPSINT_RS09505	COG3684	Belongs to the aldolase LacD family
SPSINT_RS09520	COG1349	DNA-binding transcription factor activity
SPSINT_RS09540	COG3682	Transcriptional regulator
SPSINT_RS09600	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SPSINT_RS09605	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SPSINT_RS09610	COG0101	tRNA pseudouridine synthase activity
SPSINT_RS09620	COG1122	ATPase activity
SPSINT_RS09625	COG1122	ATPase activity
SPSINT_RS09630	COG0203	ribosomal protein L17
SPSINT_RS09635	COG0202	RNA polymerase activity
SPSINT_RS09640	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SPSINT_RS09650	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SPSINT_RS09665	COG0201	protein transport
SPSINT_RS09675	COG1841	ribosomal large subunit assembly
SPSINT_RS09680	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SPSINT_RS09690	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SPSINT_RS09695	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SPSINT_RS09700	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SPSINT_RS09715	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SPSINT_RS09725	COG0255	Belongs to the universal ribosomal protein uL29 family
SPSINT_RS09730	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SPSINT_RS09735	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SPSINT_RS09740	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SPSINT_RS09745	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SPSINT_RS09750	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SPSINT_RS09755	COG0089	rRNA binding
SPSINT_RS09760	COG0088	Forms part of the polypeptide exit tunnel
SPSINT_RS09765	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SPSINT_RS09780	COG2252	PERMEase
SPSINT_RS09805	COG0436	Aminotransferase
SPSINT_RS09810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SPSINT_RS09815	COG2348	transferase activity, transferring amino-acyl groups
SPSINT_RS09840	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SPSINT_RS09845	COG0746	molybdenum cofactor guanylyltransferase activity
SPSINT_RS09855	COG0314	molybdopterin synthase activity
SPSINT_RS09875	COG0521	Mo-molybdopterin cofactor biosynthetic process
SPSINT_RS09880	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SPSINT_RS09885	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
SPSINT_RS09890	COG4149	molybdate abc transporter
SPSINT_RS09900	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SPSINT_RS09905	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SPSINT_RS09910	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SPSINT_RS09915	COG1609	Transcriptional regulator
SPSINT_RS09930	COG1268	BioY protein
SPSINT_RS09940	COG2186	Transcriptional regulator
SPSINT_RS09950	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPSINT_RS09955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SPSINT_RS09960	COG2832	Protein of unknown function (DUF454)
SPSINT_RS09965	COG1960	acyl-CoA dehydrogenase activity
SPSINT_RS09985	COG3942	CHAP domain
SPSINT_RS09995	COG1757	Na H antiporter
SPSINT_RS10005	COG3942	CHAP domain
SPSINT_RS10010	COG2076	Multidrug Resistance protein
SPSINT_RS10015	COG2076	Multidrug Resistance protein
SPSINT_RS10020	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SPSINT_RS10045	COG3383	formate dehydrogenase (NAD+) activity
SPSINT_RS10050	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SPSINT_RS10065	COG1316	TRANSCRIPTIONal
SPSINT_RS10085	COG1113	amino acid transport
SPSINT_RS10110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SPSINT_RS10115	COG0346	lactoylglutathione lyase activity
SPSINT_RS10125	COG0385	Bile acid
SPSINT_RS10145	COG1473	amidohydrolase
SPSINT_RS10150	COG0659	secondary active sulfate transmembrane transporter activity
SPSINT_RS10155	COG1228	amidohydrolase
SPSINT_RS10160	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SPSINT_RS10165	COG3314	Sporulation integral membrane protein YlbJ
SPSINT_RS10170	COG0583	DNA-binding transcription factor activity
SPSINT_RS10175	COG1266	CAAX protease self-immunity
SPSINT_RS10185	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SPSINT_RS10190	COG2258	MOSC domain
SPSINT_RS10195	COG2017	converts alpha-aldose to the beta-anomer
SPSINT_RS10200	COG1742	UPF0060 membrane protein
SPSINT_RS10205	COG1668	transmembrane transport
SPSINT_RS10210	COG4152	abc transporter atp-binding protein
SPSINT_RS10215	COG3152	Membrane
SPSINT_RS10220	COG2094	Belongs to the DNA glycosylase MPG family
SPSINT_RS10225	COG1757	Na H antiporter
SPSINT_RS10245	COG3250	beta-galactosidase activity
SPSINT_RS10250	COG2207	Transcriptional regulator
SPSINT_RS10255	COG0786	glutamate:sodium symporter activity
SPSINT_RS10260	COG3328	transposase activity
SPSINT_RS10275	COG0523	cobalamin synthesis protein
SPSINT_RS10280	COG1304	FMN binding
SPSINT_RS10300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SPSINT_RS10310	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SPSINT_RS10345	COG0577	efflux transmembrane transporter activity
SPSINT_RS10360	COG0579	oxidoreductase
SPSINT_RS10365	COG0438	transferase activity, transferring glycosyl groups
SPSINT_RS10370	COG1620	l-lactate permease
SPSINT_RS10400	COG0604	alcohol dehydrogenase
SPSINT_RS10405	COG2814	Major facilitator Superfamily
SPSINT_RS10410	COG0492	ferredoxin-NADP+ reductase activity
SPSINT_RS10430	COG1283	sodium-dependent phosphate transmembrane transporter activity
SPSINT_RS10445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPSINT_RS10445	COG1263	PTS System
SPSINT_RS10455	COG2807	transmembrane transport
SPSINT_RS10465	COG0697	spore germination
SPSINT_RS10470	COG1363	Peptidase, m42
SPSINT_RS10475	COG0039	L-malate dehydrogenase activity
SPSINT_RS10485	COG4187	Peptidase family M20/M25/M40
SPSINT_RS10490	COG2223	nitrite transmembrane transporter activity
SPSINT_RS10495	COG2197	response regulator
SPSINT_RS10500	COG4585	Histidine kinase
SPSINT_RS10510	COG2181	nitrate reductase activity
SPSINT_RS10520	COG1140	nitrate reductase beta subunit
SPSINT_RS10525	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
SPSINT_RS10535	COG0737	Belongs to the 5'-nucleotidase family
SPSINT_RS10540	COG1648	precorrin-2 dehydrogenase activity
SPSINT_RS10540	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SPSINT_RS10545	COG2146	nitrite reductase [NAD(P)H] activity
SPSINT_RS10550	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SPSINT_RS10555	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
SPSINT_RS10555	COG1648	precorrin-2 dehydrogenase activity
SPSINT_RS10565	COG0454	-acetyltransferase
SPSINT_RS10570	COG2116	formate transmembrane transporter activity
SPSINT_RS10575	COG0471	metal ion transport
SPSINT_RS10625	COG1760	l-serine dehydratase
SPSINT_RS10630	COG1760	l-serine dehydratase
SPSINT_RS10640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SPSINT_RS10645	COG0702	epimerase
SPSINT_RS10650	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
SPSINT_RS10670	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
SPSINT_RS10680	COG1929	Belongs to the glycerate kinase type-1 family
SPSINT_RS10685	COG3764	Sortase (surface protein transpeptidase)
SPSINT_RS10690	COG2271	Major facilitator Superfamily
SPSINT_RS10695	COG2814	Major facilitator Superfamily
SPSINT_RS10700	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
SPSINT_RS10705	COG1115	amino acid carrier protein
SPSINT_RS10710	COG3871	stress protein (general stress protein 26)
SPSINT_RS10720	COG0789	Transcriptional regulator
SPSINT_RS10760	COG0791	NLP P60 protein
SPSINT_RS10760	COG0741	lytic transglycosylase activity
SPSINT_RS10790	COG2946	Replication initiation factor
SPSINT_RS10800	COG1674	ftsk spoiiie
SPSINT_RS10820	COG1132	(ABC) transporter
SPSINT_RS10825	COG1132	(ABC) transporter
SPSINT_RS10830	COG0247	lactate metabolic process
SPSINT_RS10835	COG0277	FAD linked oxidase domain protein
SPSINT_RS10855	COG0159	tryptophan synthase activity
SPSINT_RS10860	COG0133	tryptophan synthase activity
SPSINT_RS10870	COG0134	indole-3-glycerol-phosphate synthase activity
SPSINT_RS10880	COG0512	Glutamine amidotransferase of anthranilate synthase
SPSINT_RS10885	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SPSINT_RS10890	COG3961	Belongs to the TPP enzyme family
SPSINT_RS10895	COG2855	membrane
SPSINT_RS10900	COG3835	regulator
SPSINT_RS10915	COG1028	Short-chain dehydrogenase reductase Sdr
SPSINT_RS10955	COG2357	RelA SpoT domain protein
SPSINT_RS10960	COG0778	Nitroreductase
SPSINT_RS10965	COG1846	Transcriptional regulator
SPSINT_RS10975	COG1346	cytolysis
SPSINT_RS10985	COG0583	DNA-binding transcription factor activity
SPSINT_RS11010	COG1141	Ferredoxin
SPSINT_RS11020	COG0523	cobalamin synthesis protein
SPSINT_RS11025	COG0717	Belongs to the dCTP deaminase family
SPSINT_RS11030	COG0804	urea catabolic process
SPSINT_RS11035	COG0832	Belongs to the urease beta subunit family
SPSINT_RS11055	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
SPSINT_RS11065	COG0577	efflux transmembrane transporter activity
SPSINT_RS11070	COG1136	(ABC) transporter
SPSINT_RS11095	COG3001	Fructosamine kinase
SPSINT_RS11100	COG0778	Nitroreductase
SPSINT_RS11115	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SPSINT_RS11115	COG0463	Glycosyl transferase, family 2
SPSINT_RS11140	COG0747	negative chemotaxis
SPSINT_RS11145	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SPSINT_RS11150	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SPSINT_RS11160	COG3942	CHAP domain
SPSINT_RS11160	COG1705	Flagellar rod assembly protein muramidase FlgJ
SPSINT_RS11170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPSINT_RS11170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPSINT_RS11170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SPSINT_RS11175	COG0789	Transcriptional regulator
SPSINT_RS11180	COG0596	Alpha beta hydrolase
SPSINT_RS11195	COG1012	belongs to the aldehyde dehydrogenase family
SPSINT_RS11200	COG2824	Alkylphosphonate utilization operon protein PhnA
SPSINT_RS11205	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SPSINT_RS11210	COG1461	Dihydroxyacetone kinase
SPSINT_RS11215	COG2376	Dihydroxyacetone kinase
SPSINT_RS11255	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SPSINT_RS11260	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SPSINT_RS11265	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SPSINT_RS11270	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SPSINT_RS11285	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SPSINT_RS11290	COG0107	imidazoleglycerol-phosphate synthase activity
SPSINT_RS11305	COG0156	8-amino-7-oxononanoate synthase activity
SPSINT_RS11310	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SPSINT_RS11315	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SPSINT_RS11320	COG1012	belongs to the aldehyde dehydrogenase family
SPSINT_RS11325	COG1510	regulation of RNA biosynthetic process
SPSINT_RS11350	COG1785	Belongs to the alkaline phosphatase family
SPSINT_RS11365	COG1396	sequence-specific DNA binding
SPSINT_RS11370	COG2807	transmembrane transport
SPSINT_RS11375	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
SPSINT_RS11380	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
SPSINT_RS11395	COG1957	nucleoside hydrolase
SPSINT_RS11400	COG3250	beta-galactosidase activity
SPSINT_RS11405	COG2211	Major facilitator Superfamily
SPSINT_RS11410	COG0477	Major facilitator Superfamily
SPSINT_RS11415	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
SPSINT_RS11420	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SPSINT_RS11430	COG2972	Histidine kinase
SPSINT_RS11435	COG2207	Transcriptional regulator
SPSINT_RS11435	COG4753	response regulator
SPSINT_RS11460	COG0803	Belongs to the bacterial solute-binding protein 9 family
SPSINT_RS11460	COG3443	Belongs to the bacterial solute-binding protein 9 family
SPSINT_RS11470	COG1942	4-Oxalocrotonate Tautomerase
SPSINT_RS11475	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SPSINT_RS11495	COG1328	CTP reductase activity
SPSINT_RS11500	COG3037	sugar-specific permease SgaT UlaA
SPSINT_RS11510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPSINT_RS11515	COG3711	transcriptional antiterminator
SPSINT_RS11540	COG1869	D-ribose catabolic process
SPSINT_RS11545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SPSINT_RS11550	COG1609	Transcriptional regulator
SPSINT_RS11580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SPSINT_RS11590	COG2814	Major facilitator Superfamily
SPSINT_RS11600	COG0318	PFAM AMP-dependent synthetase and ligase
SPSINT_RS11605	COG1960	acyl-CoA dehydrogenase activity
SPSINT_RS11615	COG0183	Belongs to the thiolase family
SPSINT_RS11640	COG1073	alpha beta
SPSINT_RS11660	COG0579	oxidoreductase
SPSINT_RS11680	COG1755	Isoprenylcysteine carboxyl methyltransferase
SPSINT_RS11695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SPSINT_RS11705	COG1136	(ABC) transporter
SPSINT_RS11730	COG0436	Aminotransferase
SPSINT_RS11740	COG0783	Belongs to the Dps family
SPSINT_RS11750	COG0753	catalase activity
SPSINT_RS11755	COG2318	DinB family
SPSINT_RS11770	COG0076	glutamate decarboxylase activity
SPSINT_RS11785	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SPSINT_RS11830	COG0156	8-amino-7-oxononanoate synthase activity
SPSINT_RS11835	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
SPSINT_RS11840	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
SPSINT_RS11845	COG1620	l-lactate permease
SPSINT_RS11860	COG1063	alcohol dehydrogenase
SPSINT_RS11880	COG3314	Sporulation integral membrane protein YlbJ
SPSINT_RS11900	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SPSINT_RS11910	COG3716	PTS system mannose fructose sorbose family IID component
SPSINT_RS11915	COG3715	PTS system
SPSINT_RS11920	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SPSINT_RS11920	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
SPSINT_RS11935	COG1105	Belongs to the carbohydrate kinase PfkB family
SPSINT_RS11940	COG2222	sugar isomerase
SPSINT_RS11945	COG2188	Transcriptional regulator
SPSINT_RS11950	COG0366	Alpha amylase catalytic
SPSINT_RS11960	COG1131	(ABC) transporter
SPSINT_RS11985	COG0346	lactoylglutathione lyase activity
SPSINT_RS11995	COG0490	domain, Protein
SPSINT_RS12000	COG0475	glutathione-regulated potassium exporter activity
SPSINT_RS12005	COG3842	ATPase activity
SPSINT_RS12015	COG1175	transmembrane transport
SPSINT_RS12020	COG3833	ABC-type maltose transport systems, permease component
SPSINT_RS12030	COG0366	Alpha amylase catalytic
SPSINT_RS12040	COG0673	inositol 2-dehydrogenase activity
SPSINT_RS12050	COG1609	Transcriptional regulator
SPSINT_RS12070	COG0431	NADPH-dependent FMN reductase
SPSINT_RS12090	COG1131	(ABC) transporter
SPSINT_RS12095	COG0842	Transport permease protein
SPSINT_RS12100	COG2203	Gaf domain
SPSINT_RS12100	COG4585	Histidine kinase
SPSINT_RS12105	COG2197	response regulator
SPSINT_RS12120	COG2235	arginine
SPSINT_RS12140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
SPSINT_RS12145	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
SPSINT_RS12155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SPSINT_RS12160	COG3177	Filamentation induced by cAMP protein fic
SPSINT_RS12170	COG2130	NADP-dependent
SPSINT_RS12175	COG0702	epimerase
SPSINT_RS12190	COG0415	Belongs to the DNA photolyase family
SPSINT_RS12200	COG2723	6-phospho-beta-galactosidase activity
SPSINT_RS12205	COG2188	Transcriptional regulator
SPSINT_RS12215	COG2217	Heavy metal translocating P-type atpase
SPSINT_RS12220	COG0531	amino acid
SPSINT_RS12240	COG2311	Membrane
SPSINT_RS12265	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SPSINT_RS12270	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SPSINT_RS12280	COG4863	YycH protein
SPSINT_RS12285	COG5002	protein histidine kinase activity
SPSINT_RS12290	COG0745	RESPONSE REGULATOR receiver
SPSINT_RS12310	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SPSINT_RS12315	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SPSINT_RS12320	COG0305	Participates in initiation and elongation during chromosome replication
SPSINT_RS12325	COG0359	binds to the 23S rRNA
SPSINT_RS12330	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
SPSINT_RS12335	COG4241	membrane
SPSINT_RS12340	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SPSINT_RS12350	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
SPSINT_RS12360	COG2986	histidine ammonia-lyase
SPSINT_RS12365	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SPSINT_RS12375	COG0187	DNA topoisomerase II activity
SPSINT_RS12380	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SPSINT_RS12385	COG2501	S4 domain
SPSINT_RS12395	COG0592	DNA-directed DNA polymerase activity
SPSINT_RS12400	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SPSINT_RS12405	COG0488	(ABC) transporter
SPSINT_RS12445	COG0582	viral genome integration into host DNA
SPSINT_RS12450	COG0582	viral genome integration into host DNA