locus-tag	class	description
A9I66_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A9I66_RS00010	COG0592	DNA-directed DNA polymerase activity
A9I66_RS00015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A9I66_RS00015	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A9I66_RS00020	COG2501	S4 domain
A9I66_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A9I66_RS00030	COG0187	DNA topoisomerase II activity
A9I66_RS00040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A9I66_RS00045	COG2986	histidine ammonia-lyase
A9I66_RS00055	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A9I66_RS00065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A9I66_RS00070	COG4241	membrane
A9I66_RS00080	COG0359	binds to the 23S rRNA
A9I66_RS00085	COG0305	Participates in initiation and elongation during chromosome replication
A9I66_RS00090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A9I66_RS00095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A9I66_RS00115	COG0745	RESPONSE REGULATOR receiver
A9I66_RS00120	COG5002	protein histidine kinase activity
A9I66_RS00125	COG4863	YycH protein
A9I66_RS00135	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A9I66_RS00185	COG2030	dehydratase
A9I66_RS00190	COG0584	glycerophosphoryl diester phosphodiesterase
A9I66_RS00215	COG1388	LysM domain
A9I66_RS00295	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A9I66_RS00315	COG0464	growth
A9I66_RS00330	COG0542	response to heat
A9I66_RS00355	COG2311	Membrane
A9I66_RS00375	COG0531	amino acid
A9I66_RS00380	COG2217	Heavy metal translocating P-type atpase
A9I66_RS00390	COG2188	Transcriptional regulator
A9I66_RS00395	COG2723	6-phospho-beta-galactosidase activity
A9I66_RS00405	COG0415	Belongs to the DNA photolyase family
A9I66_RS00420	COG0702	epimerase
A9I66_RS00425	COG2130	NADP-dependent
A9I66_RS00435	COG3177	Filamentation induced by cAMP protein fic
A9I66_RS00440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A9I66_RS00450	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A9I66_RS00455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A9I66_RS00475	COG2235	arginine
A9I66_RS00490	COG2197	response regulator
A9I66_RS00495	COG4585	Histidine kinase
A9I66_RS00495	COG2203	Gaf domain
A9I66_RS00500	COG0842	Transport permease protein
A9I66_RS00505	COG1131	(ABC) transporter
A9I66_RS00525	COG0431	NADPH-dependent FMN reductase
A9I66_RS00560	COG1609	Transcriptional regulator
A9I66_RS00570	COG0673	inositol 2-dehydrogenase activity
A9I66_RS00580	COG0366	Alpha amylase catalytic
A9I66_RS00590	COG3833	ABC-type maltose transport systems, permease component
A9I66_RS00595	COG1175	transmembrane transport
A9I66_RS00605	COG3842	ATPase activity
A9I66_RS00610	COG0475	glutathione-regulated potassium exporter activity
A9I66_RS00615	COG0490	domain, Protein
A9I66_RS00625	COG0346	lactoylglutathione lyase activity
A9I66_RS00665	COG1131	(ABC) transporter
A9I66_RS00675	COG0366	Alpha amylase catalytic
A9I66_RS00680	COG2188	Transcriptional regulator
A9I66_RS00685	COG2222	sugar isomerase
A9I66_RS00690	COG1105	Belongs to the carbohydrate kinase PfkB family
A9I66_RS00705	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A9I66_RS00705	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A9I66_RS00710	COG3715	PTS system
A9I66_RS00715	COG3716	PTS system mannose fructose sorbose family IID component
A9I66_RS00725	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A9I66_RS00745	COG3314	Sporulation integral membrane protein YlbJ
A9I66_RS00765	COG1063	alcohol dehydrogenase
A9I66_RS00780	COG1620	l-lactate permease
A9I66_RS00785	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A9I66_RS00790	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A9I66_RS00795	COG0156	8-amino-7-oxononanoate synthase activity
A9I66_RS00840	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A9I66_RS00855	COG0076	glutamate decarboxylase activity
A9I66_RS00870	COG2318	DinB family
A9I66_RS00885	COG0783	Belongs to the Dps family
A9I66_RS00895	COG0436	Aminotransferase
A9I66_RS00920	COG1136	(ABC) transporter
A9I66_RS00930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A9I66_RS00950	COG1755	Isoprenylcysteine carboxyl methyltransferase
A9I66_RS00975	COG0579	oxidoreductase
A9I66_RS01015	COG1073	alpha beta
A9I66_RS01035	COG0438	transferase activity, transferring glycosyl groups
A9I66_RS01040	COG0183	Belongs to the thiolase family
A9I66_RS01050	COG1960	acyl-CoA dehydrogenase activity
A9I66_RS01055	COG0318	PFAM AMP-dependent synthetase and ligase
A9I66_RS01065	COG2814	Major facilitator Superfamily
A9I66_RS01075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A9I66_RS01105	COG1609	Transcriptional regulator
A9I66_RS01110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A9I66_RS01115	COG1869	D-ribose catabolic process
A9I66_RS01140	COG3711	transcriptional antiterminator
A9I66_RS01145	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A9I66_RS01155	COG3037	sugar-specific permease SgaT UlaA
A9I66_RS01160	COG1328	CTP reductase activity
A9I66_RS01185	COG1942	4-Oxalocrotonate Tautomerase
A9I66_RS01195	COG3443	Belongs to the bacterial solute-binding protein 9 family
A9I66_RS01195	COG0803	Belongs to the bacterial solute-binding protein 9 family
A9I66_RS01220	COG2207	Transcriptional regulator
A9I66_RS01220	COG4753	response regulator
A9I66_RS01225	COG2972	Histidine kinase
A9I66_RS01240	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A9I66_RS01245	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A9I66_RS01250	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A9I66_RS01255	COG0477	Major facilitator Superfamily
A9I66_RS01260	COG2211	Major facilitator Superfamily
A9I66_RS01265	COG3250	beta-galactosidase activity
A9I66_RS01270	COG1957	nucleoside hydrolase
A9I66_RS01285	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A9I66_RS01290	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
A9I66_RS01295	COG2807	transmembrane transport
A9I66_RS01300	COG1396	sequence-specific DNA binding
A9I66_RS01315	COG1785	Belongs to the alkaline phosphatase family
A9I66_RS01320	COG0494	nUDIX hydrolase
A9I66_RS01325	COG0556	nucleotide-excision repair
A9I66_RS01340	COG1510	regulation of RNA biosynthetic process
A9I66_RS01345	COG1012	belongs to the aldehyde dehydrogenase family
A9I66_RS01350	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A9I66_RS01355	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A9I66_RS01365	COG0107	imidazoleglycerol-phosphate synthase activity
A9I66_RS01370	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A9I66_RS01385	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A9I66_RS01390	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A9I66_RS01395	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A9I66_RS01400	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A9I66_RS01435	COG2376	Dihydroxyacetone kinase
A9I66_RS01440	COG1461	Dihydroxyacetone kinase
A9I66_RS01445	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
A9I66_RS01450	COG2824	Alkylphosphonate utilization operon protein PhnA
A9I66_RS01455	COG1012	belongs to the aldehyde dehydrogenase family
A9I66_RS01470	COG0596	Alpha beta hydrolase
A9I66_RS01475	COG0789	Transcriptional regulator
A9I66_RS01480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A9I66_RS01480	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A9I66_RS01480	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A9I66_RS01490	COG3942	CHAP domain
A9I66_RS01490	COG1705	Flagellar rod assembly protein muramidase FlgJ
A9I66_RS01500	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A9I66_RS01505	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A9I66_RS01510	COG0747	negative chemotaxis
A9I66_RS01535	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A9I66_RS01535	COG0463	Glycosyl transferase, family 2
A9I66_RS01540	COG0463	Glycosyl transferase, family 2
A9I66_RS01540	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A9I66_RS01545	COG0438	transferase activity, transferring glycosyl groups
A9I66_RS01550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A9I66_RS01555	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A9I66_RS01575	COG3181	Tripartite tricarboxylate transporter family receptor
A9I66_RS01580	COG0778	Nitroreductase
A9I66_RS01585	COG3001	Fructosamine kinase
A9I66_RS01610	COG1136	(ABC) transporter
A9I66_RS01615	COG0577	efflux transmembrane transporter activity
A9I66_RS01635	COG4413	Urea transporter
A9I66_RS01655	COG0717	Belongs to the dCTP deaminase family
A9I66_RS01670	COG1141	Ferredoxin
A9I66_RS01695	COG0583	DNA-binding transcription factor activity
A9I66_RS01705	COG1346	cytolysis
A9I66_RS01715	COG1846	Transcriptional regulator
A9I66_RS01720	COG0778	Nitroreductase
A9I66_RS01735	COG0588	phosphoglycerate mutase activity
A9I66_RS01740	COG0318	PFAM AMP-dependent synthetase and ligase
A9I66_RS01745	COG0183	Belongs to the thiolase family
A9I66_RS01775	COG2363	Small membrane protein
A9I66_RS01780	COG3835	regulator
A9I66_RS01785	COG2855	membrane
A9I66_RS01790	COG3961	Belongs to the TPP enzyme family
A9I66_RS01795	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A9I66_RS01800	COG0512	Glutamine amidotransferase of anthranilate synthase
A9I66_RS01810	COG0134	indole-3-glycerol-phosphate synthase activity
A9I66_RS01820	COG0133	tryptophan synthase activity
A9I66_RS01825	COG0159	tryptophan synthase activity
A9I66_RS01845	COG0277	FAD linked oxidase domain protein
A9I66_RS01850	COG0247	lactate metabolic process
A9I66_RS01855	COG1132	(ABC) transporter
A9I66_RS01860	COG1132	(ABC) transporter
A9I66_RS01865	COG0789	Transcriptional regulator
A9I66_RS01875	COG3871	stress protein (general stress protein 26)
A9I66_RS01880	COG1115	amino acid carrier protein
A9I66_RS01885	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
A9I66_RS01890	COG2814	Major facilitator Superfamily
A9I66_RS01895	COG2271	Major facilitator Superfamily
A9I66_RS01900	COG3764	Sortase (surface protein transpeptidase)
A9I66_RS01905	COG1929	Belongs to the glycerate kinase type-1 family
A9I66_RS01915	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
A9I66_RS01935	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A9I66_RS01940	COG0702	epimerase
A9I66_RS01945	COG4166	transmembrane transport
A9I66_RS01950	COG0444	Belongs to the ABC transporter superfamily
A9I66_RS01955	COG4608	Belongs to the ABC transporter superfamily
A9I66_RS01960	COG0601	transmembrane transport
A9I66_RS01965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A9I66_RS01970	COG4166	transmembrane transport
A9I66_RS01975	COG0444	Belongs to the ABC transporter superfamily
A9I66_RS01980	COG4608	Belongs to the ABC transporter superfamily
A9I66_RS01985	COG0601	transmembrane transport
A9I66_RS01990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A9I66_RS02000	COG1760	l-serine dehydratase
A9I66_RS02005	COG1760	l-serine dehydratase
A9I66_RS02035	COG0471	metal ion transport
A9I66_RS02040	COG2116	formate transmembrane transporter activity
A9I66_RS02045	COG0454	-acetyltransferase
A9I66_RS02055	COG1648	precorrin-2 dehydrogenase activity
A9I66_RS02055	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A9I66_RS02060	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A9I66_RS02065	COG2146	nitrite reductase [NAD(P)H] activity
A9I66_RS02070	COG1648	precorrin-2 dehydrogenase activity
A9I66_RS02070	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A9I66_RS02075	COG0737	Belongs to the 5'-nucleotidase family
A9I66_RS02110	COG0018	arginyl-trna synthetase
A9I66_RS02120	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A9I66_RS02125	COG1140	nitrate reductase beta subunit
A9I66_RS02135	COG2181	nitrate reductase activity
A9I66_RS02145	COG4585	Histidine kinase
A9I66_RS02150	COG2197	response regulator
A9I66_RS02155	COG2223	nitrite transmembrane transporter activity
A9I66_RS02165	COG4187	Peptidase family M20/M25/M40
A9I66_RS02175	COG0039	L-malate dehydrogenase activity
A9I66_RS02180	COG1363	Peptidase, m42
A9I66_RS02185	COG0697	spore germination
A9I66_RS02195	COG2807	transmembrane transport
A9I66_RS02205	COG1263	PTS System
A9I66_RS02205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A9I66_RS02220	COG1283	sodium-dependent phosphate transmembrane transporter activity
A9I66_RS02240	COG0492	ferredoxin-NADP+ reductase activity
A9I66_RS02245	COG2814	Major facilitator Superfamily
A9I66_RS02250	COG0604	alcohol dehydrogenase
A9I66_RS02265	COG1620	l-lactate permease
A9I66_RS02270	COG0438	transferase activity, transferring glycosyl groups
A9I66_RS02275	COG0579	oxidoreductase
A9I66_RS02290	COG0577	efflux transmembrane transporter activity
A9I66_RS02325	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A9I66_RS02335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A9I66_RS02355	COG1304	FMN binding
A9I66_RS02360	COG0523	cobalamin synthesis protein
A9I66_RS02365	COG0786	glutamate:sodium symporter activity
A9I66_RS02370	COG2207	Transcriptional regulator
A9I66_RS02395	COG1757	Na H antiporter
A9I66_RS02400	COG2094	Belongs to the DNA glycosylase MPG family
A9I66_RS02405	COG3152	Membrane
A9I66_RS02410	COG4152	abc transporter atp-binding protein
A9I66_RS02415	COG1668	transmembrane transport
A9I66_RS02425	COG2017	converts alpha-aldose to the beta-anomer
A9I66_RS02430	COG2258	MOSC domain
A9I66_RS02435	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A9I66_RS02445	COG1266	CAAX protease self-immunity
A9I66_RS02450	COG0583	DNA-binding transcription factor activity
A9I66_RS02455	COG3314	Sporulation integral membrane protein YlbJ
A9I66_RS02460	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A9I66_RS02465	COG1228	amidohydrolase
A9I66_RS02470	COG0659	secondary active sulfate transmembrane transporter activity
A9I66_RS02475	COG1473	amidohydrolase
A9I66_RS02495	COG0385	Bile acid
A9I66_RS02505	COG0346	lactoylglutathione lyase activity
A9I66_RS02510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A9I66_RS02535	COG1113	amino acid transport
A9I66_RS02555	COG1316	TRANSCRIPTIONal
A9I66_RS02570	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
A9I66_RS02575	COG3383	formate dehydrogenase (NAD+) activity
A9I66_RS02600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A9I66_RS02605	COG2076	Multidrug Resistance protein
A9I66_RS02610	COG2076	Multidrug Resistance protein
A9I66_RS02615	COG3942	CHAP domain
A9I66_RS02625	COG1757	Na H antiporter
A9I66_RS02635	COG3942	CHAP domain
A9I66_RS02655	COG1960	acyl-CoA dehydrogenase activity
A9I66_RS02675	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A9I66_RS02755	COG0305	Participates in initiation and elongation during chromosome replication
A9I66_RS02825	COG0756	dUTP diphosphatase activity
A9I66_RS02835	COG2226	methyltransferase
A9I66_RS02855	COG3728	DNA packaging
A9I66_RS02855	COG5484	DNA packaging
A9I66_RS02860	COG1783	phage Terminase large subunit
A9I66_RS02985	COG2832	Protein of unknown function (DUF454)
A9I66_RS02990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A9I66_RS02995	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A9I66_RS03005	COG2186	Transcriptional regulator
A9I66_RS03015	COG1268	BioY protein
A9I66_RS03030	COG1609	Transcriptional regulator
A9I66_RS03035	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A9I66_RS03040	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A9I66_RS03045	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
A9I66_RS03055	COG4149	molybdate abc transporter
A9I66_RS03060	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A9I66_RS03065	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A9I66_RS03070	COG0521	Mo-molybdopterin cofactor biosynthetic process
A9I66_RS03100	COG0746	molybdenum cofactor guanylyltransferase activity
A9I66_RS03105	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A9I66_RS03130	COG2348	transferase activity, transferring amino-acyl groups
A9I66_RS03135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A9I66_RS03140	COG0436	Aminotransferase
A9I66_RS03160	COG0551	DNA topoisomerase type I activity
A9I66_RS03160	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A9I66_RS03165	COG2252	PERMEase
A9I66_RS03185	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A9I66_RS03190	COG0088	Forms part of the polypeptide exit tunnel
A9I66_RS03195	COG0089	rRNA binding
A9I66_RS03200	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A9I66_RS03205	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A9I66_RS03210	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A9I66_RS03215	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A9I66_RS03220	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A9I66_RS03225	COG0255	Belongs to the universal ribosomal protein uL29 family
A9I66_RS03235	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A9I66_RS03250	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A9I66_RS03255	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A9I66_RS03260	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A9I66_RS03270	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A9I66_RS03275	COG1841	ribosomal large subunit assembly
A9I66_RS03285	COG0201	protein transport
A9I66_RS03300	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A9I66_RS03310	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A9I66_RS03315	COG0202	RNA polymerase activity
A9I66_RS03320	COG0203	ribosomal protein L17
A9I66_RS03325	COG1122	ATPase activity
A9I66_RS03330	COG1122	ATPase activity
A9I66_RS03340	COG0101	tRNA pseudouridine synthase activity
A9I66_RS03345	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A9I66_RS03350	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A9I66_RS03400	COG1349	DNA-binding transcription factor activity
A9I66_RS03415	COG3684	Belongs to the aldolase LacD family
A9I66_RS03425	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A9I66_RS03425	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A9I66_RS03435	COG0488	(ABC) transporter
A9I66_RS03440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A9I66_RS03450	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A9I66_RS03465	COG1302	Protein conserved in bacteria
A9I66_RS03470	COG2814	Major facilitator Superfamily
A9I66_RS03475	COG4264	IucA IucC family
A9I66_RS03480	COG2814	Major facilitator Superfamily
A9I66_RS03485	COG4264	IucA IucC family
A9I66_RS03490	COG3457	Alanine racemase
A9I66_RS03495	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A9I66_RS03500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A9I66_RS03505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A9I66_RS03510	COG3314	Sporulation integral membrane protein YlbJ
A9I66_RS03520	COG1988	membrane-bound metal-dependent
A9I66_RS03525	COG4284	Utp--glucose-1-phosphate uridylyltransferase
A9I66_RS03530	COG1272	protein, Hemolysin III
A9I66_RS03550	COG2814	Major facilitator Superfamily
A9I66_RS03555	COG0489	protein tyrosine kinase activity
A9I66_RS03615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A9I66_RS03630	COG3711	transcriptional antiterminator
A9I66_RS03650	COG0210	DNA helicase
A9I66_RS03655	COG3344	reverse transcriptase
A9I66_RS03665	COG1119	ATPase activity
A9I66_RS03670	COG0561	phosphatase activity
A9I66_RS03680	COG2186	Transcriptional regulator
A9I66_RS03685	COG1482	cell wall glycoprotein biosynthetic process
A9I66_RS03705	COG1757	Na H antiporter
A9I66_RS03715	COG0813	purine-nucleoside phosphorylase activity
A9I66_RS03750	COG5146	pantothenate kinase activity
A9I66_RS03765	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A9I66_RS03775	COG0504	CTP synthase activity
A9I66_RS03780	COG2271	Major facilitator Superfamily
A9I66_RS03785	COG4821	SIS domain
A9I66_RS03790	COG0191	fructose-bisphosphate aldolase activity
A9I66_RS03795	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A9I66_RS03800	COG1733	regulation of RNA biosynthetic process
A9I66_RS03810	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A9I66_RS03815	COG0254	rRNA binding
A9I66_RS03825	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A9I66_RS03830	COG2890	protein-(glutamine-N5) methyltransferase activity
A9I66_RS03835	COG0009	L-threonylcarbamoyladenylate synthase
A9I66_RS03840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A9I66_RS03845	COG4475	Protein of unknown function (DUF436)
A9I66_RS03850	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A9I66_RS03855	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A9I66_RS03860	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A9I66_RS03870	COG0356	it plays a direct role in the translocation of protons across the membrane
A9I66_RS03875	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A9I66_RS03885	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A9I66_RS03895	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A9I66_RS03925	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A9I66_RS03940	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A9I66_RS03950	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A9I66_RS03955	COG0352	thiamine-phosphate diphosphorylase activity
A9I66_RS03960	COG0706	membrane insertase activity
A9I66_RS03965	COG1418	mRNA catabolic process
A9I66_RS03970	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A9I66_RS03975	COG1937	Protein conserved in bacteria
A9I66_RS03990	COG2217	Heavy metal translocating P-type atpase
A9I66_RS04005	COG0772	Belongs to the SEDS family
A9I66_RS04010	COG1181	Belongs to the D-alanine--D-alanine ligase family
A9I66_RS04020	COG0513	Belongs to the DEAD box helicase family
A9I66_RS04035	COG3402	PFAM membrane-flanked domain
A9I66_RS04040	COG0736	holo-[acyl-carrier-protein] synthase activity
A9I66_RS04045	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A9I66_RS04055	COG2337	Toxic component of a toxin-antitoxin (TA) module
A9I66_RS04060	COG2208	phosphoserine phosphatase activity
A9I66_RS04065	COG1366	Belongs to the anti-sigma-factor antagonist family
A9I66_RS04075	COG1191	sigma factor activity
A9I66_RS04080	COG2183	response to ionizing radiation
A9I66_RS04085	COG3091	SprT-like family
A9I66_RS04130	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A9I66_RS04140	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A9I66_RS04145	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A9I66_RS04155	COG0028	Belongs to the TPP enzyme family
A9I66_RS04160	COG0129	dihydroxy-acid dehydratase activity
A9I66_RS04165	COG0802	atpase or kinase
A9I66_RS04170	COG1214	PFAM Peptidase M22, glycoprotease
A9I66_RS04175	COG0456	acetyltransferase
A9I66_RS04180	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A9I66_RS04185	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A9I66_RS04190	COG0488	(ABC) transporter
A9I66_RS04195	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A9I66_RS04200	COG2814	Major facilitator Superfamily
A9I66_RS04205	COG1846	Transcriptional regulator
A9I66_RS04215	COG2124	cytochrome p450
A9I66_RS04220	COG1609	Transcriptional regulator
A9I66_RS04225	COG1621	beta-fructofuranosidase activity
A9I66_RS04230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A9I66_RS04250	COG4512	PFAM Accessory gene regulator B
A9I66_RS04285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A9I66_RS04290	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A9I66_RS04305	COG1131	(ABC) transporter
A9I66_RS04320	COG1070	Carbohydrate kinase
A9I66_RS04325	COG2610	gluconate transmembrane transporter activity
A9I66_RS04355	COG2706	6-phosphogluconolactonase activity
A9I66_RS04360	COG1012	belongs to the aldehyde dehydrogenase family
A9I66_RS04370	COG1227	inorganic diphosphatase activity
A9I66_RS04375	COG1335	isochorismatase
A9I66_RS04385	COG0077	Prephenate dehydratase
A9I66_RS04395	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A9I66_RS04415	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A9I66_RS04420	COG4496	protein, YerC YecD
A9I66_RS04425	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
A9I66_RS04430	COG0210	DNA helicase
A9I66_RS04435	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A9I66_RS04440	COG4851	CamS sex pheromone cAM373 precursor
A9I66_RS04445	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A9I66_RS04450	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A9I66_RS04460	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A9I66_RS04465	COG1597	lipid kinase activity
A9I66_RS04490	COG0488	(ABC) transporter
A9I66_RS04495	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A9I66_RS04500	COG1396	sequence-specific DNA binding
A9I66_RS04510	COG2211	Major facilitator Superfamily
A9I66_RS04520	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A9I66_RS04530	COG1528	Iron-storage protein
A9I66_RS04545	COG4129	membrane
A9I66_RS04550	COG0024	Methionine aminopeptidase
A9I66_RS04575	COG0288	reversible hydration of carbon dioxide
A9I66_RS04580	COG1295	ribonuclease BN
A9I66_RS04595	COG4840	Belongs to the UPF0435 family
A9I66_RS04600	COG2309	aminopeptidase activity
A9I66_RS04605	COG1607	acyl-coa hydrolase
A9I66_RS04610	COG0535	radical SAM domain protein
A9I66_RS04615	COG0693	protein deglycase activity
A9I66_RS04620	COG0028	Belongs to the TPP enzyme family
A9I66_RS04625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A9I66_RS04630	COG2137	regulation of response to DNA damage stimulus
A9I66_RS04640	COG1134	teichoic acid transport
A9I66_RS04640	COG1388	LysM domain
A9I66_RS04650	COG1988	membrane-bound metal-dependent
A9I66_RS04655	COG1194	a g-specific adenine glycosylase
A9I66_RS04660	COG3557	Belongs to the UPF0374 family
A9I66_RS04670	COG0069	glutamate synthase activity
A9I66_RS04675	COG4129	membrane
A9I66_RS04680	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A9I66_RS04685	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A9I66_RS04695	COG0735	belongs to the Fur family
A9I66_RS04925	COG0765	amino acid transport
A9I66_RS04930	COG1126	abc transporter atp-binding protein
A9I66_RS04935	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A9I66_RS04945	COG0363	glucosamine-6-phosphate deaminase activity
A9I66_RS04955	COG0114	fumarate hydratase activity
A9I66_RS04960	COG0248	Ppx GppA phosphatase
A9I66_RS04965	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A9I66_RS04970	COG0564	pseudouridine synthase activity
A9I66_RS04975	COG2203	Gaf domain
A9I66_RS04975	COG4585	Histidine kinase
A9I66_RS04980	COG2197	response regulator
A9I66_RS04985	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A9I66_RS05000	COG4399	Belongs to the UPF0754 family
A9I66_RS05005	COG3679	Belongs to the UPF0342 family
A9I66_RS05010	COG0420	3'-5' exonuclease activity
A9I66_RS05020	COG3481	metal-dependent phosphohydrolase, HD sub domain
A9I66_RS05025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A9I66_RS05035	COG1846	Transcriptional regulator
A9I66_RS05045	COG0537	adenosine 5'-monophosphoramidase activity
A9I66_RS05050	COG1131	(ABC) transporter
A9I66_RS05055	COG4473	ABC transporter
A9I66_RS05060	COG3344	reverse transcriptase
A9I66_RS05070	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A9I66_RS05080	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A9I66_RS05085	COG3545	Serine hydrolase
A9I66_RS05170	COG3037	sugar-specific permease SgaT UlaA
A9I66_RS05190	COG3623	hexulose-6-phosphate isomerase
A9I66_RS05195	COG0235	Class ii aldolase
A9I66_RS05215	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A9I66_RS05220	COG0494	nUDIX hydrolase
A9I66_RS05225	COG1506	peptidase
A9I66_RS05230	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A9I66_RS05245	COG0656	L-ascorbic acid biosynthetic process
A9I66_RS05250	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A9I66_RS05265	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A9I66_RS05290	COG4193	domain, Protein
A9I66_RS05290	COG5632	N-Acetylmuramoyl-L-alanine amidase
A9I66_RS05290	COG3266	domain, Protein
A9I66_RS05300	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A9I66_RS05300	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A9I66_RS05305	COG0307	riboflavin synthase, alpha
A9I66_RS05310	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A9I66_RS05310	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A9I66_RS05315	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A9I66_RS05330	COG2267	carboxylic ester hydrolase activity
A9I66_RS05335	COG0039	L-malate dehydrogenase activity
A9I66_RS05345	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A9I66_RS05350	COG1242	4 iron, 4 sulfur cluster binding
A9I66_RS05355	COG2814	Major facilitator Superfamily
A9I66_RS05360	COG0495	leucyl-tRNA aminoacylation
A9I66_RS05365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A9I66_RS05370	COG2081	HI0933 family
A9I66_RS05375	COG2244	polysaccharide biosynthetic process
A9I66_RS05380	COG1187	pseudouridine synthase activity
A9I66_RS05390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A9I66_RS05395	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A9I66_RS05400	COG0510	thiamine kinase activity
A9I66_RS05405	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A9I66_RS05410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A9I66_RS05420	COG1363	Peptidase, m42
A9I66_RS05425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A9I66_RS05430	COG4848	Belongs to the UPF0354 family
A9I66_RS05435	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A9I66_RS05440	COG1674	ftsk spoiiie
A9I66_RS05445	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A9I66_RS05450	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
A9I66_RS05460	COG1605	Chorismate mutase
A9I66_RS05460	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A9I66_RS05465	COG1609	Transcriptional regulator
A9I66_RS05480	COG0454	-acetyltransferase
A9I66_RS05485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A9I66_RS05490	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A9I66_RS05495	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A9I66_RS05505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A9I66_RS05510	COG0204	Acyl-transferase
A9I66_RS05520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A9I66_RS05525	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A9I66_RS05530	COG1764	response to oxidative stress
A9I66_RS05570	COG3344	reverse transcriptase
A9I66_RS05585	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A9I66_RS05590	COG1956	GAF domain-containing protein
A9I66_RS05600	COG1104	cysteine desulfurase activity
A9I66_RS05605	COG0301	tRNA thio-modification
A9I66_RS05615	COG0616	signal peptide processing
A9I66_RS05620	COG1714	RDD family
A9I66_RS05625	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A9I66_RS05630	COG0827	DNA restriction-modification system
A9I66_RS05635	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A9I66_RS05640	COG0589	response to stress
A9I66_RS05645	COG0686	Belongs to the AlaDH PNT family
A9I66_RS05655	COG0006	proline dipeptidase activity
A9I66_RS05660	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A9I66_RS05670	COG4109	DRTGG domain
A9I66_RS05675	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A9I66_RS05680	COG0587	DNA-directed DNA polymerase activity
A9I66_RS05685	COG0281	malic enzyme
A9I66_RS05695	COG0825	malonyl-CoA metabolic process
A9I66_RS05700	COG0205	6-phosphofructokinase activity
A9I66_RS05705	COG0469	pyruvate kinase activity
A9I66_RS05710	COG0372	Belongs to the citrate synthase family
A9I66_RS05715	COG0538	isocitrate dehydrogenase activity
A9I66_RS05725	COG5002	protein histidine kinase activity
A9I66_RS05730	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A9I66_RS05730	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A9I66_RS05740	COG0237	dephospho-CoA kinase activity
A9I66_RS05745	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A9I66_RS05755	COG3611	Membrane attachment protein
A9I66_RS05760	COG1484	DNA-dependent DNA replication
A9I66_RS05770	COG0833	amino acid
A9I66_RS05775	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A9I66_RS05780	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A9I66_RS05785	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A9I66_RS05800	COG0544	peptidyl-prolyl cis-trans isomerase activity
A9I66_RS05810	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A9I66_RS05815	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A9I66_RS05840	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A9I66_RS05850	COG2818	Glycosylase
A9I66_RS05855	COG0525	valine-tRNA ligase activity
A9I66_RS05860	COG0285	dihydrofolate synthase activity
A9I66_RS05870	COG2003	Belongs to the UPF0758 family
A9I66_RS05895	COG2868	ribosomal protein
A9I66_RS05905	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A9I66_RS05915	COG0632	four-way junction helicase activity
A9I66_RS05920	COG2255	four-way junction helicase activity
A9I66_RS05925	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A9I66_RS05935	COG1862	Preprotein translocase
A9I66_RS05940	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A9I66_RS05940	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A9I66_RS05945	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A9I66_RS05945	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A9I66_RS05950	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A9I66_RS05960	COG1490	D-aminoacyl-tRNA deacylase activity
A9I66_RS05965	COG0860	N-Acetylmuramoyl-L-alanine amidase
A9I66_RS05975	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A9I66_RS05985	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A9I66_RS05990	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A9I66_RS05995	COG1959	2 iron, 2 sulfur cluster binding
A9I66_RS06010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A9I66_RS06015	COG1104	cysteine desulfurase activity
A9I66_RS06020	COG0482	sulfurtransferase activity
A9I66_RS06030	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A9I66_RS06035	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A9I66_RS06040	COG4472	Bacterial protein of unknown function (DUF965)
A9I66_RS06045	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A9I66_RS06050	COG3906	Belongs to the UPF0473 family
A9I66_RS06055	COG4122	O-methyltransferase activity
A9I66_RS06060	COG0826	peptidase U32
A9I66_RS06065	COG0826	peptidase U32
A9I66_RS06070	COG0572	uridine kinase
A9I66_RS06085	COG1984	allophanate hydrolase subunit 2
A9I66_RS06090	COG0511	ligase activity, forming carbon-carbon bonds
A9I66_RS06095	COG0439	Biotin carboxylase
A9I66_RS06100	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A9I66_RS06105	COG1914	H( )-stimulated, divalent metal cation uptake system
A9I66_RS06110	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A9I66_RS06115	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A9I66_RS06120	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A9I66_RS06125	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A9I66_RS06130	COG1534	Rna-binding protein
A9I66_RS06140	COG1713	HD superfamily hydrolase involved in NAD metabolism
A9I66_RS06145	COG0799	negative regulation of ribosome biogenesis
A9I66_RS06150	COG2226	methyltransferase
A9I66_RS06155	COG1596	polysaccharide export
A9I66_RS06155	COG1555	photosystem II stabilization
A9I66_RS06160	COG2131	deaminase
A9I66_RS06170	COG1466	dna polymerase III delta subunit
A9I66_RS06175	COG0268	Binds directly to 16S ribosomal RNA
A9I66_RS06185	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A9I66_RS06205	COG0484	heat shock protein binding
A9I66_RS06210	COG2264	protein methyltransferase activity
A9I66_RS06215	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A9I66_RS06220	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A9I66_RS06235	COG1030	water channel activity
A9I66_RS06240	COG4864	UPF0365 protein
A9I66_RS06250	COG1702	phosphate starvation-inducible protein PhoH
A9I66_RS06260	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A9I66_RS06270	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A9I66_RS06275	COG1381	Involved in DNA repair and RecF pathway recombination
A9I66_RS06280	COG0423	glycine-tRNA ligase activity
A9I66_RS06285	COG0517	IMP dehydrogenase activity
A9I66_RS06290	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A9I66_RS06295	COG0358	DNA primase activity
A9I66_RS06300	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A9I66_RS06305	COG2384	SAM-dependent methyltransferase
A9I66_RS06310	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A9I66_RS06315	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A9I66_RS06320	COG0513	Belongs to the DEAD box helicase family
A9I66_RS06325	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A9I66_RS06330	COG1121	(ABC) transporter
A9I66_RS06335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A9I66_RS06340	COG0735	belongs to the Fur family
A9I66_RS06345	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A9I66_RS06355	COG0768	penicillin binding
A9I66_RS06360	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A9I66_RS06365	COG0573	inorganic phosphate transmembrane transporter activity
A9I66_RS06370	COG0581	inorganic phosphate transmembrane transporter activity
A9I66_RS06375	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A9I66_RS06380	COG0704	Plays a role in the regulation of phosphate uptake
A9I66_RS06390	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A9I66_RS06395	COG0705	Rhomboid family
A9I66_RS06395	COG0457	Tetratricopeptide repeat
A9I66_RS06400	COG4483	Protein conserved in bacteria
A9I66_RS06405	COG1940	carbohydrate kinase activity
A9I66_RS06410	COG0011	TIGRFAM Protein of
A9I66_RS06415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A9I66_RS06420	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A9I66_RS06445	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A9I66_RS06450	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A9I66_RS06460	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A9I66_RS06465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A9I66_RS06470	COG0095	Lipoate-protein ligase
A9I66_RS06485	COG0006	proline dipeptidase activity
A9I66_RS06490	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A9I66_RS06495	COG0511	ligase activity, forming carbon-carbon bonds
A9I66_RS06500	COG0439	Biotin carboxylase
A9I66_RS06505	COG1302	Protein conserved in bacteria
A9I66_RS06515	COG1570	exodeoxyribonuclease VII activity
A9I66_RS06520	COG1722	exodeoxyribonuclease VII activity
A9I66_RS06525	COG0142	geranyltranstransferase activity
A9I66_RS06530	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A9I66_RS06535	COG1438	arginine binding
A9I66_RS06540	COG0497	DNA recombination
A9I66_RS06545	COG0280	phosphate acetyltransferase
A9I66_RS06555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A9I66_RS06560	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A9I66_RS06565	COG0022	dehydrogenase e1 component
A9I66_RS06570	COG0508	dehydrogenase complex catalyzes the overall conversion of
A9I66_RS06580	COG4129	membrane
A9I66_RS06585	COG2195	Cleaves the N-terminal amino acid of tripeptides
A9I66_RS06620	COG1234	tRNA 3'-trailer cleavage
A9I66_RS06635	COG0667	Aldo Keto reductase
A9I66_RS06640	COG0494	nUDIX hydrolase
A9I66_RS06645	COG0735	belongs to the Fur family
A9I66_RS06660	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A9I66_RS06670	COG1187	pseudouridine synthase activity
A9I66_RS06675	COG0745	RESPONSE REGULATOR receiver
A9I66_RS06690	COG1141	Ferredoxin
A9I66_RS06700	COG0514	ATP-dependent DNA helicase (RecQ)
A9I66_RS06710	COG0492	ferredoxin-NADP+ reductase activity
A9I66_RS06715	COG0252	asparaginase activity
A9I66_RS06725	COG0539	negative regulation of cytoplasmic translation
A9I66_RS06730	COG1160	GTP binding
A9I66_RS06735	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A9I66_RS06755	COG0142	geranyltranstransferase activity
A9I66_RS06760	COG0105	UTP biosynthetic process
A9I66_RS06770	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A9I66_RS06780	COG0457	Tetratricopeptide repeat
A9I66_RS06785	COG5582	Belongs to the UPF0302 family
A9I66_RS06790	COG4347	Protein of unknown function (DUF1405)
A9I66_RS06805	COG0438	transferase activity, transferring glycosyl groups
A9I66_RS06810	COG0617	tRNA 3'-terminal CCA addition
A9I66_RS06825	COG0017	Asparaginyl-tRNA synthetase
A9I66_RS06830	COG3935	DnaD domain protein
A9I66_RS06835	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A9I66_RS06845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A9I66_RS06845	COG4499	WXG100 protein secretion system (Wss), protein YukC
A9I66_RS06860	COG4474	Belongs to the UPF0398 family
A9I66_RS06865	COG3599	regulation of cell shape
A9I66_RS06875	COG0116	Belongs to the methyltransferase superfamily
A9I66_RS06880	COG2962	Rard protein
A9I66_RS06885	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A9I66_RS06900	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A9I66_RS06910	COG1413	lyase activity
A9I66_RS06945	COG2190	(PTS) system
A9I66_RS06955	COG0793	Belongs to the peptidase S41A family
A9I66_RS06965	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A9I66_RS06970	COG0671	phosphoesterase, PA-phosphatase related
A9I66_RS06980	COG5002	protein histidine kinase activity
A9I66_RS07015	COG4548	von Willebrand factor, type A
A9I66_RS07020	COG1114	Component of the transport system for branched-chain amino acids
A9I66_RS07025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A9I66_RS07030	COG3853	Toxic anion resistance protein (TelA)
A9I66_RS07050	COG1278	Cold shock
A9I66_RS07070	COG1473	amidohydrolase
A9I66_RS07075	COG2171	N-acyltransferase activity
A9I66_RS07080	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A9I66_RS07085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A9I66_RS07090	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A9I66_RS07095	COG0488	(ABC) transporter
A9I66_RS07135	COG1363	Peptidase, m42
A9I66_RS07140	COG0287	Prephenate dehydrogenase
A9I66_RS07145	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A9I66_RS07155	COG1942	4-Oxalocrotonate Tautomerase
A9I66_RS07175	COG0628	permease
A9I66_RS07185	COG3711	transcriptional antiterminator
A9I66_RS07190	COG1115	amino acid carrier protein
A9I66_RS07195	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A9I66_RS07205	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A9I66_RS07210	COG4841	protein insertion into membrane
A9I66_RS07215	COG0824	Thioesterase
A9I66_RS07230	COG1970	mechanosensitive ion channel activity
A9I66_RS07245	COG4846	Membrane protein involved in cytochrome C biogenesis
A9I66_RS07250	COG3763	UPF0154 protein
A9I66_RS07260	COG4224	UPF0291 protein
A9I66_RS07270	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A9I66_RS07280	COG0516	GMP reductase activity
A9I66_RS07285	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A9I66_RS07295	COG0833	amino acid
A9I66_RS07310	COG0083	homoserine kinase activity
A9I66_RS07315	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A9I66_RS07320	COG0460	homoserine dehydrogenase
A9I66_RS07345	COG1525	nuclease
A9I66_RS07375	COG0584	glycerophosphoryl diester phosphodiesterase
A9I66_RS07395	COG0789	Transcriptional regulator
A9I66_RS07400	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
A9I66_RS07405	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A9I66_RS07410	COG0386	Belongs to the glutathione peroxidase family
A9I66_RS07415	COG2267	carboxylic ester hydrolase activity
A9I66_RS07420	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A9I66_RS07425	COG1923	regulation of RNA biosynthetic process
A9I66_RS07430	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A9I66_RS07440	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A9I66_RS07445	COG1619	proteins homologs of microcin C7 resistance protein MccF
A9I66_RS07450	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
A9I66_RS07455	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A9I66_RS07475	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A9I66_RS07485	COG1013	pyruvate-flavodoxin oxidoreductase activity
A9I66_RS07490	COG0674	pyruvate-flavodoxin oxidoreductase activity
A9I66_RS07490	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A9I66_RS07495	COG1692	metallophosphoesterase
A9I66_RS07515	COG1418	mRNA catabolic process
A9I66_RS07520	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A9I66_RS07525	COG1058	Belongs to the CinA family
A9I66_RS07525	COG1546	Belongs to the CinA family
A9I66_RS07545	COG0300	oxidoreductase activity
A9I66_RS07555	COG0612	Peptidase, M16
A9I66_RS07585	COG0196	riboflavin kinase activity
A9I66_RS07590	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A9I66_RS07595	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A9I66_RS07635	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A9I66_RS07650	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A9I66_RS07650	COG1372	Participates in initiation and elongation during chromosome replication
A9I66_RS07655	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A9I66_RS07665	COG1780	Probably involved in ribonucleotide reductase function
A9I66_RS07750	COG0587	DNA-directed DNA polymerase activity
A9I66_RS07975	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A9I66_RS07995	COG2887	Belongs to the helicase family. UvrD subfamily
A9I66_RS08175	COG4373	Mu-like prophage FluMu protein gp28
A9I66_RS08240	COG0582	viral genome integration into host DNA
A9I66_RS08245	COG0741	lytic transglycosylase activity
A9I66_RS08245	COG1196	nuclear chromosome segregation
A9I66_RS08245	COG0739	heme binding
A9I66_RS08250	COG0739	heme binding
A9I66_RS08250	COG0741	lytic transglycosylase activity
A9I66_RS08250	COG1196	nuclear chromosome segregation
A9I66_RS08260	COG2433	Pfam Transposase IS66
A9I66_RS08320	COG4974	Belongs to the 'phage' integrase family
A9I66_RS08325	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A9I66_RS08330	COG1358	cellular component organization or biogenesis
A9I66_RS08335	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A9I66_RS08340	COG0195	Participates in both transcription termination and antitermination
A9I66_RS08345	COG0779	Required for maturation of 30S ribosomal subunits
A9I66_RS08355	COG0442	prolyl-tRNA aminoacylation
A9I66_RS08365	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A9I66_RS08370	COG4589	Belongs to the CDS family
A9I66_RS08380	COG0233	cytoplasmic translational termination
A9I66_RS08385	COG0528	UMP kinase activity
A9I66_RS08390	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A9I66_RS08395	COG0052	Belongs to the universal ribosomal protein uS2 family
A9I66_RS08400	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A9I66_RS08405	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A9I66_RS08410	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A9I66_RS08415	COG4974	Belongs to the 'phage' integrase family
A9I66_RS08420	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A9I66_RS08430	COG0758	DNA mediated transformation
A9I66_RS08440	COG0045	succinate-CoA ligase (ADP-forming) activity
A9I66_RS08450	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A9I66_RS08465	COG4485	Bacterial membrane protein, YfhO
A9I66_RS08510	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A9I66_RS08515	COG0228	four-way junction DNA binding
A9I66_RS08525	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A9I66_RS08570	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A9I66_RS08575	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
A9I66_RS08580	COG0552	protein localization to endoplasmic reticulum
A9I66_RS08585	COG1196	nuclear chromosome segregation
A9I66_RS08590	COG0571	ribonuclease III activity
A9I66_RS08595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A9I66_RS08610	COG0416	fatty acid biosynthetic process
A9I66_RS08615	COG1349	DNA-binding transcription factor activity
A9I66_RS08625	COG1760	l-serine dehydratase
A9I66_RS08630	COG1760	l-serine dehydratase
A9I66_RS08640	COG1302	Protein conserved in bacteria
A9I66_RS08655	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A9I66_RS08660	COG1162	GTPase activity
A9I66_RS08665	COG2124	cytochrome p450
A9I66_RS08680	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A9I66_RS08690	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A9I66_RS08695	COG0242	peptide deformylase activity
A9I66_RS08700	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A9I66_RS08705	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A9I66_RS08710	COG1758	RNA polymerase activity
A9I66_RS08730	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A9I66_RS08735	COG0284	orotidine-5'-phosphate decarboxylase activity
A9I66_RS08740	COG0167	dihydroorotate dehydrogenase activity
A9I66_RS08750	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A9I66_RS08755	COG0505	Belongs to the CarA family
A9I66_RS08775	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A9I66_RS08780	COG0564	pseudouridine synthase activity
A9I66_RS08785	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A9I66_RS08795	COG3599	regulation of cell shape
A9I66_RS08805	COG0673	inositol 2-dehydrogenase activity
A9I66_RS08810	COG4409	exo-alpha-(2->6)-sialidase activity
A9I66_RS08820	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A9I66_RS08825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A9I66_RS08835	COG4975	Glucose uptake
A9I66_RS08840	COG1869	D-ribose catabolic process
A9I66_RS08845	COG0762	integral membrane protein
A9I66_RS08850	COG1799	cell septum assembly
A9I66_RS08855	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A9I66_RS08865	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A9I66_RS08870	COG0849	cell division
A9I66_RS08880	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A9I66_RS08890	COG0768	penicillin binding
A9I66_RS08895	COG4839	cell division protein FtsL
A9I66_RS08900	COG0275	rRNA processing
A9I66_RS08905	COG2001	Belongs to the MraZ family
A9I66_RS08910	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
A9I66_RS08915	COG0454	-acetyltransferase
A9I66_RS08920	COG1011	Hydrolase
A9I66_RS08930	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A9I66_RS08965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A9I66_RS08970	COG0783	Belongs to the Dps family
A9I66_RS09010	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A9I66_RS09015	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A9I66_RS09020	COG1053	succinate dehydrogenase
A9I66_RS09025	COG2009	succinate dehydrogenase
A9I66_RS09030	COG0322	excinuclease ABC activity
A9I66_RS09035	COG3118	belongs to the thioredoxin family
A9I66_RS09040	COG1193	negative regulation of DNA recombination
A9I66_RS09045	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A9I66_RS09045	COG1796	DNA polymerase
A9I66_RS09060	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A9I66_RS09075	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A9I66_RS09085	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A9I66_RS09105	COG0742	ribosomal rna small subunit methyltransferase
A9I66_RS09115	COG4471	UPF0298 protein
A9I66_RS09120	COG0584	glycerophosphoryl diester phosphodiesterase
A9I66_RS09125	COG3679	Belongs to the UPF0342 family
A9I66_RS09140	COG0109	protoheme IX farnesyltransferase activity
A9I66_RS09165	COG0772	Belongs to the SEDS family
A9I66_RS09170	COG4838	Belongs to the UPF0358 family
A9I66_RS09175	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A9I66_RS09180	COG4896	Protein conserved in bacteria
A9I66_RS09185	COG1902	pentaerythritol trinitrate reductase activity
A9I66_RS09190	COG1217	gtp-binding protein TYPA
A9I66_RS09200	COG0483	inositol monophosphate 1-phosphatase activity
A9I66_RS09205	COG4493	Belongs to the UPF0637 family
A9I66_RS09220	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A9I66_RS09225	COG1177	transmembrane transport
A9I66_RS09235	COG3842	ATPase activity
A9I66_RS09245	COG4476	Belongs to the UPF0223 family
A9I66_RS09285	COG5503	Protein of unknown function (DUF1447)
A9I66_RS09290	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A9I66_RS09295	COG0569	domain protein
A9I66_RS09300	COG1294	oxidase, subunit
A9I66_RS09305	COG1271	oxidase subunit
A9I66_RS09310	COG1393	Belongs to the ArsC family
A9I66_RS09315	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A9I66_RS09320	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A9I66_RS09330	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A9I66_RS09345	COG4172	Belongs to the ABC transporter superfamily
A9I66_RS09355	COG0151	Belongs to the GarS family
A9I66_RS09360	COG0138	bifunctional purine biosynthesis protein purh
A9I66_RS09370	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A9I66_RS09375	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A9I66_RS09385	COG0047	phosphoribosylformylglycinamidine synthase activity
A9I66_RS09390	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A9I66_RS09395	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A9I66_RS09400	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A9I66_RS09405	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A9I66_RS09410	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A9I66_RS09415	COG1017	nitric oxide dioxygenase activity
A9I66_RS09415	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A9I66_RS09425	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A9I66_RS09435	COG1845	cytochrome c oxidase, subunit III
A9I66_RS09440	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A9I66_RS09450	COG3973	AAA domain
A9I66_RS09490	COG3212	peptidase
A9I66_RS09505	COG1134	teichoic acid transport
A9I66_RS09515	COG1682	transport, permease protein
A9I66_RS09525	COG1215	transferase activity, transferring glycosyl groups
A9I66_RS09535	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A9I66_RS09545	COG1316	TRANSCRIPTIONal
A9I66_RS09570	COG3594	Acyltransferase
A9I66_RS09575	COG0436	Aminotransferase
A9I66_RS09580	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A9I66_RS09590	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A9I66_RS09595	COG1169	isochorismate synthase
A9I66_RS09600	COG1575	Belongs to the MenA family. Type 1 subfamily
A9I66_RS09605	COG0390	transport system, permease component
A9I66_RS09610	COG4619	ABC transporter
A9I66_RS09630	COG4873	Protein conserved in bacteria
A9I66_RS09680	COG2378	regulation of single-species biofilm formation
A9I66_RS09690	COG0456	acetyltransferase
A9I66_RS09700	COG2226	methyltransferase
A9I66_RS09725	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A9I66_RS09740	COG0737	Belongs to the 5'-nucleotidase family
A9I66_RS09750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A9I66_RS09755	COG1696	Membrane protein involved in D-alanine export
A9I66_RS09765	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A9I66_RS09770	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A9I66_RS09775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A9I66_RS09780	COG0861	Integral membrane protein TerC family
A9I66_RS09785	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A9I66_RS09795	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A9I66_RS09805	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A9I66_RS09810	COG2814	Major facilitator Superfamily
A9I66_RS09820	COG3715	PTS system
A9I66_RS09825	COG3716	PTS system mannose fructose sorbose family IID component
A9I66_RS09830	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A9I66_RS09835	COG2382	esterase
A9I66_RS09840	COG1115	amino acid carrier protein
A9I66_RS09845	COG0628	permease
A9I66_RS09855	COG0475	glutathione-regulated potassium exporter activity
A9I66_RS09855	COG0569	domain protein
A9I66_RS09860	COG2239	Acts as a magnesium transporter
A9I66_RS09865	COG0564	pseudouridine synthase activity
A9I66_RS09875	COG2357	RelA SpoT domain protein
A9I66_RS09890	COG2346	COG2346, Truncated hemoglobins
A9I66_RS09895	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A9I66_RS09905	COG1164	Oligoendopeptidase f
A9I66_RS09920	COG3591	Belongs to the peptidase S1B family
A9I66_RS09930	COG1393	Belongs to the ArsC family
A9I66_RS09935	COG0180	Tryptophanyl-tRNA synthetase
A9I66_RS09940	COG4166	transmembrane transport
A9I66_RS09945	COG4608	Belongs to the ABC transporter superfamily
A9I66_RS09950	COG0444	Belongs to the ABC transporter superfamily
A9I66_RS09955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A9I66_RS09960	COG0601	transmembrane transport
A9I66_RS09985	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A9I66_RS10005	COG0561	phosphatase activity
A9I66_RS10010	COG0446	pyridine nucleotide-disulphide oxidoreductase
A9I66_RS10020	COG0179	Fumarylacetoacetate (FAA) hydrolase
A9I66_RS10045	COG0166	Belongs to the GPI family
A9I66_RS10050	COG0137	argininosuccinate synthase activity
A9I66_RS10060	COG0584	glycerophosphoryl diester phosphodiesterase
A9I66_RS10075	COG1012	belongs to the aldehyde dehydrogenase family
A9I66_RS10080	COG1098	S1 RNA binding domain
A9I66_RS10095	COG1278	Cold shock
A9I66_RS10115	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A9I66_RS10125	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A9I66_RS10125	COG2111	Na H antiporter
A9I66_RS10130	COG2111	Na H antiporter
A9I66_RS10135	COG1006	Multisubunit Na H antiporter MnhC subunit
A9I66_RS10140	COG0651	ATP synthesis coupled electron transport
A9I66_RS10145	COG1863	multisubunit Na H antiporter MnhE subunit
A9I66_RS10150	COG2212	antiporter activity
A9I66_RS10155	COG1320	monovalent cation:proton antiporter activity
A9I66_RS10165	COG2056	Na+-H+ antiporter family
A9I66_RS10170	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A9I66_RS10175	COG1252	NADH dehydrogenase
A9I66_RS10180	COG0316	Belongs to the HesB IscA family
A9I66_RS10185	COG4844	belongs to the
A9I66_RS10190	COG1252	NADH dehydrogenase
A9I66_RS10195	COG4837	Protein of unknown function (DUF1462)
A9I66_RS10200	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A9I66_RS10205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A9I66_RS10210	COG0647	UMP catabolic process
A9I66_RS10215	COG2445	Protein of unknown function DUF86
A9I66_RS10225	COG4470	Protein conserved in bacteria
A9I66_RS10230	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A9I66_RS10235	COG0737	Belongs to the 5'-nucleotidase family
A9I66_RS10240	COG0730	response to heat
A9I66_RS10245	COG1801	Protein of unknown function DUF72
A9I66_RS10260	COG1253	flavin adenine dinucleotide binding
A9I66_RS10270	COG0719	Fe-S assembly protein
A9I66_RS10275	COG0822	iron-sulfur transferase activity
A9I66_RS10285	COG0719	Fe-S assembly protein
A9I66_RS10290	COG0396	ATPase activity
A9I66_RS10300	COG1464	Belongs to the NlpA lipoprotein family
A9I66_RS10305	COG1464	Belongs to the NlpA lipoprotein family
A9I66_RS10310	COG2011	ABC-type metal ion transport system permease component
A9I66_RS10320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A9I66_RS10325	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A9I66_RS10335	COG1393	Belongs to the ArsC family
A9I66_RS10340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A9I66_RS10350	COG0710	3-dehydroquinate dehydratase activity
A9I66_RS10360	COG1764	response to oxidative stress
A9I66_RS10375	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A9I66_RS10395	COG0346	lactoylglutathione lyase activity
A9I66_RS10425	COG0557	exoribonuclease II activity
A9I66_RS10430	COG1647	Serine aminopeptidase, S33
A9I66_RS10435	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A9I66_RS10445	COG0148	phosphopyruvate hydratase activity
A9I66_RS10450	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A9I66_RS10455	COG0149	triose-phosphate isomerase activity
A9I66_RS10460	COG0126	phosphoglycerate kinase activity
A9I66_RS10480	COG1090	epimerase
A9I66_RS10490	COG0740	serine-type endopeptidase activity
A9I66_RS10515	COG1388	LysM domain
A9I66_RS10515	COG0860	N-Acetylmuramoyl-L-alanine amidase
A9I66_RS10590	COG4695	Portal protein
A9I66_RS10640	COG2226	methyltransferase
A9I66_RS10650	COG0756	dUTP diphosphatase activity
A9I66_RS10720	COG0305	Participates in initiation and elongation during chromosome replication
A9I66_RS10795	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A9I66_RS10810	COG1481	regulation of sporulation
A9I66_RS10815	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A9I66_RS10820	COG1660	Displays ATPase and GTPase activities
A9I66_RS10835	COG0110	maltose O-acetyltransferase activity
A9I66_RS10840	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A9I66_RS10845	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A9I66_RS10875	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A9I66_RS10880	COG0653	protein targeting
A9I66_RS10895	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A9I66_RS10905	COG1739	Uncharacterized protein family UPF0029
A9I66_RS10910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A9I66_RS10930	COG2195	Cleaves the N-terminal amino acid of tripeptides
A9I66_RS10940	COG1929	Belongs to the glycerate kinase type-1 family
A9I66_RS10945	COG3118	belongs to the thioredoxin family
A9I66_RS10960	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A9I66_RS10970	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A9I66_RS10975	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A9I66_RS11040	COG3104	oligopeptide transport
A9I66_RS11060	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A9I66_RS11065	COG1174	glycine betaine transport
A9I66_RS11070	COG1125	glycine betaine transport
A9I66_RS11070	COG0517	IMP dehydrogenase activity
A9I66_RS11075	COG0514	ATP-dependent DNA helicase (RecQ)
A9I66_RS11080	COG0488	(ABC) transporter
A9I66_RS11110	COG1368	sulfuric ester hydrolase activity
A9I66_RS11120	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A9I66_RS11140	COG0512	Glutamine amidotransferase of anthranilate synthase
A9I66_RS11150	COG0720	synthase
A9I66_RS11155	COG0602	queuosine metabolic process
A9I66_RS11170	COG0463	Glycosyl transferase, family 2
A9I66_RS11175	COG1253	flavin adenine dinucleotide binding
A9I66_RS11180	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A9I66_RS11180	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A9I66_RS11180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A9I66_RS11185	COG1105	Belongs to the carbohydrate kinase PfkB family
A9I66_RS11190	COG1349	DNA-binding transcription factor activity
A9I66_RS11215	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A9I66_RS11240	COG0039	L-malate dehydrogenase activity
A9I66_RS11260	COG4989	oxidoreductase activity
A9I66_RS11265	COG0523	cobalamin synthesis protein
A9I66_RS11275	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A9I66_RS11280	COG4988	ABC transporter
A9I66_RS11285	COG1968	undecaprenyl-diphosphatase activity
A9I66_RS11295	COG1671	Belongs to the UPF0178 family
A9I66_RS11300	COG1611	Belongs to the LOG family
A9I66_RS11330	COG2839	Protein conserved in bacteria
A9I66_RS11340	COG0583	DNA-binding transcription factor activity
A9I66_RS11355	COG0217	transcriptional regulatory protein
A9I66_RS11360	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A9I66_RS11365	COG2022	thiamine diphosphate biosynthetic process
A9I66_RS11375	COG0352	thiamine-phosphate diphosphorylase activity
A9I66_RS11385	COG1388	LysM domain
A9I66_RS11385	COG3942	CHAP domain
A9I66_RS11390	COG0306	phosphate transporter
A9I66_RS11395	COG1392	Phosphate transport regulator
A9I66_RS11400	COG0577	efflux transmembrane transporter activity
A9I66_RS11405	COG1136	(ABC) transporter
A9I66_RS11415	COG0745	RESPONSE REGULATOR receiver
A9I66_RS11420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A9I66_RS11425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A9I66_RS11435	COG3949	Membrane
A9I66_RS11440	COG0477	Major facilitator Superfamily
A9I66_RS11450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A9I66_RS11455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A9I66_RS11460	COG1120	ATPase activity
A9I66_RS11465	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A9I66_RS11470	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A9I66_RS11490	COG1132	(ABC) transporter
A9I66_RS11495	COG1686	Belongs to the peptidase S11 family
A9I66_RS11510	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A9I66_RS11515	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A9I66_RS11520	COG1682	transport, permease protein
A9I66_RS11530	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A9I66_RS11535	COG0110	maltose O-acetyltransferase activity
A9I66_RS11545	COG1475	DNA binding
A9I66_RS11550	COG0019	diaminopimelate decarboxylase activity
A9I66_RS11560	COG4264	IucA IucC family
A9I66_RS11570	COG2814	Major facilitator Superfamily
A9I66_RS11575	COG4264	IucA IucC family
A9I66_RS11580	COG2423	ornithine cyclodeaminase activity
A9I66_RS11590	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A9I66_RS11595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A9I66_RS11600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A9I66_RS11610	COG1121	(ABC) transporter
A9I66_RS11615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A9I66_RS11620	COG0803	Belongs to the bacterial solute-binding protein 9 family
A9I66_RS11630	COG1320	monovalent cation:proton antiporter activity
A9I66_RS11635	COG2212	antiporter activity
A9I66_RS11640	COG1863	multisubunit Na H antiporter MnhE subunit
A9I66_RS11650	COG1006	Multisubunit Na H antiporter MnhC subunit
A9I66_RS11655	COG2111	Na H antiporter
A9I66_RS11660	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A9I66_RS11660	COG2111	Na H antiporter
A9I66_RS11710	COG0546	phosphoglycolate phosphatase activity
A9I66_RS11715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A9I66_RS11720	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A9I66_RS11725	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A9I66_RS11730	COG0805	protein transport
A9I66_RS11735	COG0018	arginyl-trna synthetase
A9I66_RS11750	COG1078	dGTPase activity
A9I66_RS11760	COG4844	belongs to the
A9I66_RS11825	COG0471	metal ion transport
A9I66_RS11845	COG1388	LysM domain
A9I66_RS11845	COG0860	N-Acetylmuramoyl-L-alanine amidase
A9I66_RS11895	COG3344	reverse transcriptase
A9I66_RS11980	COG1783	phage Terminase large subunit
A9I66_RS12010	COG0756	dUTP diphosphatase activity
A9I66_RS12070	COG0305	Participates in initiation and elongation during chromosome replication
A9I66_RS12140	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A9I66_RS12150	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A9I66_RS12155	COG0471	metal ion transport
A9I66_RS12180	COG0280	phosphate acetyltransferase
A9I66_RS12185	COG0095	Lipoate-protein ligase
A9I66_RS12210	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A9I66_RS12215	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A9I66_RS12225	COG2814	Major facilitator Superfamily
A9I66_RS12230	COG1566	PFAM secretion protein HlyD family protein
A9I66_RS12255	COG2363	Small membrane protein
A9I66_RS12285	COG0183	Belongs to the thiolase family
A9I66_RS12290	COG0318	PFAM AMP-dependent synthetase and ligase
A9I66_RS12295	COG0588	phosphoglycerate mutase activity
A9I66_RS12310	COG3344	reverse transcriptase
A9I66_RS12320	COG1131	(ABC) transporter
A9I66_RS12325	COG1994	Peptidase M50
A9I66_RS12330	COG0535	radical SAM domain protein
A9I66_RS12350	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A9I66_RS12360	COG2814	Major facilitator Superfamily
A9I66_RS12370	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A9I66_RS12380	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A9I66_RS12395	COG1263	PTS System
A9I66_RS12395	COG2190	(PTS) system
A9I66_RS12395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A9I66_RS12410	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A9I66_RS12415	COG1469	GTP cyclohydrolase I activity
A9I66_RS12420	COG1136	(ABC) transporter
A9I66_RS12420	COG0577	efflux transmembrane transporter activity
A9I66_RS12435	COG0561	phosphatase activity
A9I66_RS12445	COG1428	Deoxynucleoside kinase
A9I66_RS12450	COG1428	Deoxynucleoside kinase
A9I66_RS12455	COG0546	phosphoglycolate phosphatase activity
A9I66_RS12470	COG0488	(ABC) transporter
A9I66_RS12475	COG1121	(ABC) transporter
A9I66_RS12490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A9I66_RS12500	COG1473	amidohydrolase
A9I66_RS12505	COG3527	Alpha-acetolactate decarboxylase
A9I66_RS12510	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A9I66_RS12520	COG0049	tRNA binding
A9I66_RS12525	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A9I66_RS12535	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A9I66_RS12540	COG0085	RNA polymerase activity
A9I66_RS12555	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A9I66_RS12560	COG0081	regulation of translation
A9I66_RS12565	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A9I66_RS12570	COG0250	Participates in transcription elongation, termination and antitermination
A9I66_RS12575	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A9I66_RS12595	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
A9I66_RS12600	COG0215	cysteine-tRNA ligase activity
A9I66_RS12605	COG1045	serine acetyltransferase
A9I66_RS12610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A9I66_RS12625	COG4956	integral membrane protein (PIN domain superfamily)
A9I66_RS12630	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A9I66_RS12665	COG0542	response to heat
A9I66_RS12670	COG3869	Catalyzes the specific phosphorylation of arginine residues in
A9I66_RS12675	COG3880	PFAM UvrB UvrC protein
A9I66_RS12685	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A9I66_RS12695	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
A9I66_RS12700	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
A9I66_RS12705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A9I66_RS12710	COG1289	transmembrane transporter activity
A9I66_RS12805	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A9I66_RS12815	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A9I66_RS12825	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A9I66_RS12835	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A9I66_RS12850	COG1098	S1 RNA binding domain
A9I66_RS12860	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A9I66_RS12865	COG3956	TIGRFAM MazG family protein
A9I66_RS12870	COG2244	polysaccharide biosynthetic process
A9I66_RS12875	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A9I66_RS12880	COG0193	aminoacyl-tRNA hydrolase activity
A9I66_RS12890	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A9I66_RS12895	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A9I66_RS12900	COG2088	sporulation resulting in formation of a cellular spore
A9I66_RS12905	COG0251	oxidation-reduction process
A9I66_RS12910	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A9I66_RS12915	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A9I66_RS12920	COG4466	Protein conserved in bacteria
A9I66_RS12930	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A9I66_RS12935	COG0084	hydrolase, TatD family'
A9I66_RS12945	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A9I66_RS12950	COG2827	Endonuclease containing a URI domain
A9I66_RS12955	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A9I66_RS12960	COG4467	Involved in initiation control of chromosome replication
A9I66_RS12965	COG1774	PSP1 C-terminal conserved region
A9I66_RS12970	COG0470	DNA polymerase III
A9I66_RS12975	COG3870	Protein conserved in bacteria
A9I66_RS12980	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A9I66_RS13010	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A9I66_RS13015	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A9I66_RS13020	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A9I66_RS13025	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A9I66_RS13035	COG2188	Transcriptional regulator
A9I66_RS13040	COG0366	Alpha amylase catalytic
A9I66_RS13045	COG1263	PTS System
A9I66_RS13045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A9I66_RS13055	COG0493	'glutamate synthase
A9I66_RS13060	COG0070	glutamate synthase
A9I66_RS13060	COG0069	glutamate synthase activity
A9I66_RS13060	COG0067	glutamate synthase
A9I66_RS13065	COG0583	DNA-binding transcription factor activity
A9I66_RS13080	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A9I66_RS13110	COG0626	cystathionine gamma-synthase activity
A9I66_RS13115	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A9I66_RS13120	COG2272	Belongs to the type-B carboxylesterase lipase family
A9I66_RS13125	COG0733	neurotransmitter:sodium symporter activity
A9I66_RS13135	COG0745	RESPONSE REGULATOR receiver
A9I66_RS13140	COG2205	protein histidine kinase activity
A9I66_RS13150	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A9I66_RS13155	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
A9I66_RS13170	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A9I66_RS13175	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A9I66_RS13175	COG0574	Belongs to the PEP-utilizing enzyme family
A9I66_RS13200	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A9I66_RS13210	COG1486	melibiose metabolic process
A9I66_RS13215	COG1263	PTS System
A9I66_RS13215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A9I66_RS13235	COG2210	Belongs to the sulfur carrier protein TusA family
A9I66_RS13240	COG1937	Protein conserved in bacteria
A9I66_RS13245	COG0730	response to heat
A9I66_RS13250	COG2814	Major facilitator Superfamily
A9I66_RS13260	COG3344	reverse transcriptase
A9I66_RS13275	COG3682	Transcriptional regulator
A9I66_RS13300	COG1124	(ABC) transporter
A9I66_RS13305	COG0444	Belongs to the ABC transporter superfamily
A9I66_RS13310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A9I66_RS13315	COG0601	transmembrane transport
A9I66_RS13320	COG0747	negative chemotaxis
A9I66_RS13345	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A9I66_RS13365	COG1525	nuclease
A9I66_RS13405	COG3617	BRO family, N-terminal domain
A9I66_RS13425	COG0582	viral genome integration into host DNA
A9I66_RS13430	COG0519	Catalyzes the synthesis of GMP from XMP
A9I66_RS13430	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A9I66_RS13435	COG0516	GMP reductase activity
A9I66_RS13435	COG0517	IMP dehydrogenase activity
A9I66_RS13445	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A9I66_RS13460	COG5183	chlorophyll binding
A9I66_RS13475	COG1136	(ABC) transporter
A9I66_RS13475	COG0577	efflux transmembrane transporter activity
A9I66_RS13490	COG0778	Nitroreductase
A9I66_RS13495	COG0450	alkyl hydroperoxide reductase
A9I66_RS13510	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A9I66_RS13520	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A9I66_RS13530	COG1464	Belongs to the NlpA lipoprotein family
A9I66_RS13535	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A9I66_RS13540	COG0753	catalase activity
A9I66_RS13550	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A9I66_RS13560	COG0360	Binds together with S18 to 16S ribosomal RNA
A9I66_RS13570	COG1668	transmembrane transport
A9I66_RS13575	COG1131	(ABC) transporter
A9I66_RS13595	COG0012	GTP binding
A9I66_RS13600	COG4481	Protein conserved in bacteria
A9I66_RS13605	COG0668	transmembrane transport
A9I66_RS13610	COG1475	DNA binding
A9I66_RS13615	COG0626	cystathionine gamma-synthase activity
A9I66_RS13620	COG0626	cystathionine gamma-synthase activity
A9I66_RS13625	COG0646	methionine synthase
A9I66_RS13625	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A9I66_RS13635	COG0829	nickel cation binding
A9I66_RS13645	COG0830	nickel cation binding
A9I66_RS13650	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
A9I66_RS13660	COG2388	GCN5-related N-acetyl-transferase
A9I66_RS13665	COG1846	Transcriptional regulator
A9I66_RS13670	COG0346	lactoylglutathione lyase activity
A9I66_RS13675	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A9I66_RS13680	COG0400	carboxylic ester hydrolase activity
A9I66_RS13700	COG0357	Ribosomal RNA small subunit methyltransferase G
A9I66_RS13705	COG0445	tRNA wobble uridine modification
A9I66_RS13710	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A9I66_RS13715	COG0594	ribonuclease P activity