locus-tag	class	description
GSP_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GSP_RS00010	COG0592	DNA-directed DNA polymerase activity
GSP_RS00015	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GSP_RS00015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GSP_RS00020	COG2501	S4 domain
GSP_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GSP_RS00030	COG0187	DNA topoisomerase II activity
GSP_RS00040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GSP_RS00045	COG2986	histidine ammonia-lyase
GSP_RS00055	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GSP_RS00065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GSP_RS00070	COG4241	membrane
GSP_RS00075	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
GSP_RS00080	COG0359	binds to the 23S rRNA
GSP_RS00090	COG0305	Participates in initiation and elongation during chromosome replication
GSP_RS00095	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GSP_RS00100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GSP_RS00120	COG0745	RESPONSE REGULATOR receiver
GSP_RS00125	COG5002	protein histidine kinase activity
GSP_RS00130	COG4863	YycH protein
GSP_RS00140	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GSP_RS00145	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GSP_RS00180	COG2311	Membrane
GSP_RS00200	COG0531	amino acid
GSP_RS00205	COG2217	Heavy metal translocating P-type atpase
GSP_RS00215	COG2188	Transcriptional regulator
GSP_RS00220	COG2723	6-phospho-beta-galactosidase activity
GSP_RS00235	COG0415	Belongs to the DNA photolyase family
GSP_RS00250	COG0702	epimerase
GSP_RS00255	COG2130	NADP-dependent
GSP_RS00270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GSP_RS00275	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GSP_RS00275	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GSP_RS00280	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GSP_RS00285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GSP_RS00305	COG2235	arginine
GSP_RS00340	COG0431	NADPH-dependent FMN reductase
GSP_RS00385	COG1609	Transcriptional regulator
GSP_RS00395	COG0673	inositol 2-dehydrogenase activity
GSP_RS00405	COG0366	Alpha amylase catalytic
GSP_RS00415	COG3833	ABC-type maltose transport systems, permease component
GSP_RS00420	COG1175	transmembrane transport
GSP_RS00430	COG3842	ATPase activity
GSP_RS00435	COG0475	glutathione-regulated potassium exporter activity
GSP_RS00440	COG0490	domain, Protein
GSP_RS00450	COG0346	lactoylglutathione lyase activity
GSP_RS00485	COG1131	(ABC) transporter
GSP_RS00495	COG0366	Alpha amylase catalytic
GSP_RS00500	COG2188	Transcriptional regulator
GSP_RS00505	COG2222	sugar isomerase
GSP_RS00510	COG1105	Belongs to the carbohydrate kinase PfkB family
GSP_RS00525	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GSP_RS00525	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GSP_RS00530	COG3715	PTS system
GSP_RS00535	COG3716	PTS system mannose fructose sorbose family IID component
GSP_RS00545	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GSP_RS00565	COG3314	Sporulation integral membrane protein YlbJ
GSP_RS00585	COG1063	alcohol dehydrogenase
GSP_RS00600	COG1620	l-lactate permease
GSP_RS00605	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GSP_RS00610	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GSP_RS00615	COG0156	8-amino-7-oxononanoate synthase activity
GSP_RS00660	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GSP_RS00675	COG0076	glutamate decarboxylase activity
GSP_RS00690	COG2318	DinB family
GSP_RS00695	COG0753	catalase activity
GSP_RS00705	COG0783	Belongs to the Dps family
GSP_RS00715	COG0436	Aminotransferase
GSP_RS00740	COG1136	(ABC) transporter
GSP_RS00750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GSP_RS00770	COG1755	Isoprenylcysteine carboxyl methyltransferase
GSP_RS00795	COG0579	oxidoreductase
GSP_RS00815	COG1073	alpha beta
GSP_RS00835	COG0438	transferase activity, transferring glycosyl groups
GSP_RS00840	COG0183	Belongs to the thiolase family
GSP_RS00855	COG0318	PFAM AMP-dependent synthetase and ligase
GSP_RS00865	COG2814	Major facilitator Superfamily
GSP_RS00875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GSP_RS00905	COG1609	Transcriptional regulator
GSP_RS00910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GSP_RS00940	COG3711	transcriptional antiterminator
GSP_RS00945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GSP_RS00955	COG3037	sugar-specific permease SgaT UlaA
GSP_RS00965	COG1328	CTP reductase activity
GSP_RS00985	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GSP_RS00990	COG1942	4-Oxalocrotonate Tautomerase
GSP_RS01000	COG3443	Belongs to the bacterial solute-binding protein 9 family
GSP_RS01000	COG0803	Belongs to the bacterial solute-binding protein 9 family
GSP_RS01025	COG4753	response regulator
GSP_RS01025	COG2207	Transcriptional regulator
GSP_RS01030	COG2972	Histidine kinase
GSP_RS01040	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GSP_RS01045	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GSP_RS01050	COG0477	Major facilitator Superfamily
GSP_RS01055	COG2211	Major facilitator Superfamily
GSP_RS01060	COG3250	beta-galactosidase activity
GSP_RS01065	COG1957	nucleoside hydrolase
GSP_RS01080	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GSP_RS01085	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
GSP_RS01090	COG2807	transmembrane transport
GSP_RS01095	COG1396	sequence-specific DNA binding
GSP_RS01110	COG1785	Belongs to the alkaline phosphatase family
GSP_RS01115	COG0494	nUDIX hydrolase
GSP_RS01120	COG0556	nucleotide-excision repair
GSP_RS01135	COG1510	regulation of RNA biosynthetic process
GSP_RS01140	COG1012	belongs to the aldehyde dehydrogenase family
GSP_RS01145	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GSP_RS01150	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GSP_RS01160	COG0107	imidazoleglycerol-phosphate synthase activity
GSP_RS01165	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GSP_RS01180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GSP_RS01185	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GSP_RS01190	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GSP_RS01195	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GSP_RS01235	COG2376	Dihydroxyacetone kinase
GSP_RS01240	COG1461	Dihydroxyacetone kinase
GSP_RS01245	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GSP_RS01250	COG2824	Alkylphosphonate utilization operon protein PhnA
GSP_RS01255	COG1012	belongs to the aldehyde dehydrogenase family
GSP_RS01270	COG0596	Alpha beta hydrolase
GSP_RS01275	COG0789	Transcriptional regulator
GSP_RS01280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GSP_RS01280	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GSP_RS01280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GSP_RS01290	COG3942	CHAP domain
GSP_RS01290	COG1705	Flagellar rod assembly protein muramidase FlgJ
GSP_RS01300	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GSP_RS01305	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GSP_RS01310	COG0747	negative chemotaxis
GSP_RS01335	COG0463	Glycosyl transferase, family 2
GSP_RS01335	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GSP_RS01340	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GSP_RS01340	COG0463	Glycosyl transferase, family 2
GSP_RS01345	COG0438	transferase activity, transferring glycosyl groups
GSP_RS01350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GSP_RS01355	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GSP_RS01370	COG3181	Tripartite tricarboxylate transporter family receptor
GSP_RS01375	COG0778	Nitroreductase
GSP_RS01380	COG3001	Fructosamine kinase
GSP_RS01405	COG1136	(ABC) transporter
GSP_RS01410	COG0577	efflux transmembrane transporter activity
GSP_RS01430	COG4413	Urea transporter
GSP_RS01440	COG0832	Belongs to the urease beta subunit family
GSP_RS01445	COG0804	urea catabolic process
GSP_RS01450	COG0717	Belongs to the dCTP deaminase family
GSP_RS01455	COG0523	cobalamin synthesis protein
GSP_RS01465	COG1141	Ferredoxin
GSP_RS01495	COG0583	DNA-binding transcription factor activity
GSP_RS01505	COG1346	cytolysis
GSP_RS01520	COG1846	Transcriptional regulator
GSP_RS01525	COG0778	Nitroreductase
GSP_RS01530	COG2357	RelA SpoT domain protein
GSP_RS01570	COG1028	Short-chain dehydrogenase reductase Sdr
GSP_RS01585	COG3835	regulator
GSP_RS01590	COG2855	membrane
GSP_RS01595	COG3961	Belongs to the TPP enzyme family
GSP_RS01600	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GSP_RS01605	COG0512	Glutamine amidotransferase of anthranilate synthase
GSP_RS01615	COG0134	indole-3-glycerol-phosphate synthase activity
GSP_RS01625	COG0133	tryptophan synthase activity
GSP_RS01630	COG0159	tryptophan synthase activity
GSP_RS01650	COG0277	FAD linked oxidase domain protein
GSP_RS01655	COG0247	lactate metabolic process
GSP_RS01660	COG1132	(ABC) transporter
GSP_RS01665	COG1132	(ABC) transporter
GSP_RS01670	COG0789	Transcriptional regulator
GSP_RS01680	COG3871	stress protein (general stress protein 26)
GSP_RS01685	COG1115	amino acid carrier protein
GSP_RS01690	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
GSP_RS01695	COG2814	Major facilitator Superfamily
GSP_RS01700	COG2271	Major facilitator Superfamily
GSP_RS01705	COG3764	Sortase (surface protein transpeptidase)
GSP_RS01710	COG1929	Belongs to the glycerate kinase type-1 family
GSP_RS01720	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
GSP_RS01740	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GSP_RS01745	COG0702	epimerase
GSP_RS01750	COG4166	transmembrane transport
GSP_RS01755	COG0444	Belongs to the ABC transporter superfamily
GSP_RS01760	COG4608	Belongs to the ABC transporter superfamily
GSP_RS01765	COG0601	transmembrane transport
GSP_RS01770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GSP_RS01775	COG4166	transmembrane transport
GSP_RS01780	COG0444	Belongs to the ABC transporter superfamily
GSP_RS01785	COG4608	Belongs to the ABC transporter superfamily
GSP_RS01790	COG0601	transmembrane transport
GSP_RS01795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GSP_RS01805	COG1760	l-serine dehydratase
GSP_RS01810	COG1760	l-serine dehydratase
GSP_RS01840	COG0471	metal ion transport
GSP_RS01845	COG2116	formate transmembrane transporter activity
GSP_RS01850	COG0454	-acetyltransferase
GSP_RS01860	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GSP_RS01860	COG1648	precorrin-2 dehydrogenase activity
GSP_RS01865	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GSP_RS01870	COG2146	nitrite reductase [NAD(P)H] activity
GSP_RS01875	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GSP_RS01875	COG1648	precorrin-2 dehydrogenase activity
GSP_RS01880	COG0737	Belongs to the 5'-nucleotidase family
GSP_RS01910	COG0018	arginyl-trna synthetase
GSP_RS01920	COG2801	Transposase and inactivated derivatives
GSP_RS01930	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GSP_RS01935	COG1140	nitrate reductase beta subunit
GSP_RS01945	COG2181	nitrate reductase activity
GSP_RS01955	COG4585	Histidine kinase
GSP_RS01960	COG2197	response regulator
GSP_RS01970	COG2223	nitrite transmembrane transporter activity
GSP_RS01975	COG4187	Peptidase family M20/M25/M40
GSP_RS01985	COG0039	L-malate dehydrogenase activity
GSP_RS01990	COG1363	Peptidase, m42
GSP_RS01995	COG0697	spore germination
GSP_RS02005	COG2807	transmembrane transport
GSP_RS02015	COG1263	PTS System
GSP_RS02015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GSP_RS02030	COG1283	sodium-dependent phosphate transmembrane transporter activity
GSP_RS02055	COG0492	ferredoxin-NADP+ reductase activity
GSP_RS02060	COG2814	Major facilitator Superfamily
GSP_RS02065	COG0604	alcohol dehydrogenase
GSP_RS02080	COG1620	l-lactate permease
GSP_RS02090	COG0438	transferase activity, transferring glycosyl groups
GSP_RS02095	COG0579	oxidoreductase
GSP_RS02110	COG0577	efflux transmembrane transporter activity
GSP_RS02145	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GSP_RS02155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GSP_RS02175	COG1304	FMN binding
GSP_RS02180	COG0523	cobalamin synthesis protein
GSP_RS02185	COG0786	glutamate:sodium symporter activity
GSP_RS02190	COG2207	Transcriptional regulator
GSP_RS02195	COG3250	beta-galactosidase activity
GSP_RS02215	COG1757	Na H antiporter
GSP_RS02220	COG2094	Belongs to the DNA glycosylase MPG family
GSP_RS02225	COG3152	Membrane
GSP_RS02230	COG4152	abc transporter atp-binding protein
GSP_RS02235	COG1668	transmembrane transport
GSP_RS02240	COG1742	UPF0060 membrane protein
GSP_RS02245	COG2017	converts alpha-aldose to the beta-anomer
GSP_RS02250	COG2258	MOSC domain
GSP_RS02255	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GSP_RS02265	COG1266	CAAX protease self-immunity
GSP_RS02270	COG0583	DNA-binding transcription factor activity
GSP_RS02275	COG3314	Sporulation integral membrane protein YlbJ
GSP_RS02280	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GSP_RS02285	COG1228	amidohydrolase
GSP_RS02290	COG0659	secondary active sulfate transmembrane transporter activity
GSP_RS02295	COG1473	amidohydrolase
GSP_RS02315	COG0385	Bile acid
GSP_RS02325	COG0346	lactoylglutathione lyase activity
GSP_RS02330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GSP_RS02355	COG1113	amino acid transport
GSP_RS02380	COG1316	TRANSCRIPTIONal
GSP_RS02395	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GSP_RS02400	COG3383	formate dehydrogenase (NAD+) activity
GSP_RS02425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GSP_RS02430	COG2076	Multidrug Resistance protein
GSP_RS02435	COG2076	Multidrug Resistance protein
GSP_RS02440	COG3942	CHAP domain
GSP_RS02450	COG1757	Na H antiporter
GSP_RS02460	COG3942	CHAP domain
GSP_RS02480	COG1960	acyl-CoA dehydrogenase activity
GSP_RS02485	COG2832	Protein of unknown function (DUF454)
GSP_RS02490	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GSP_RS02495	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GSP_RS02505	COG2186	Transcriptional regulator
GSP_RS02515	COG1268	BioY protein
GSP_RS02530	COG1609	Transcriptional regulator
GSP_RS02535	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GSP_RS02540	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GSP_RS02545	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GSP_RS02555	COG4149	molybdate abc transporter
GSP_RS02560	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GSP_RS02565	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GSP_RS02570	COG0521	Mo-molybdopterin cofactor biosynthetic process
GSP_RS02590	COG0314	molybdopterin synthase activity
GSP_RS02600	COG0746	molybdenum cofactor guanylyltransferase activity
GSP_RS02605	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GSP_RS02630	COG2348	transferase activity, transferring amino-acyl groups
GSP_RS02635	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GSP_RS02640	COG0436	Aminotransferase
GSP_RS02660	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GSP_RS02660	COG0551	DNA topoisomerase type I activity
GSP_RS02665	COG2252	PERMEase
GSP_RS02685	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GSP_RS02690	COG0088	Forms part of the polypeptide exit tunnel
GSP_RS02695	COG0089	rRNA binding
GSP_RS02700	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GSP_RS02705	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GSP_RS02710	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GSP_RS02715	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GSP_RS02720	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GSP_RS02725	COG0255	Belongs to the universal ribosomal protein uL29 family
GSP_RS02735	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GSP_RS02750	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GSP_RS02755	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GSP_RS02760	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GSP_RS02770	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GSP_RS02775	COG1841	ribosomal large subunit assembly
GSP_RS02785	COG0201	protein transport
GSP_RS02800	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GSP_RS02810	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GSP_RS02815	COG0202	RNA polymerase activity
GSP_RS02820	COG0203	ribosomal protein L17
GSP_RS02825	COG1122	ATPase activity
GSP_RS02830	COG1122	ATPase activity
GSP_RS02840	COG0101	tRNA pseudouridine synthase activity
GSP_RS02845	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GSP_RS02870	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GSP_RS02910	COG3684	Belongs to the aldolase LacD family
GSP_RS02920	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GSP_RS02920	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GSP_RS02930	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
GSP_RS02935	COG1518	maintenance of DNA repeat elements
GSP_RS02955	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GSP_RS02970	COG1302	Protein conserved in bacteria
GSP_RS02975	COG2814	Major facilitator Superfamily
GSP_RS02980	COG4264	IucA IucC family
GSP_RS02985	COG2814	Major facilitator Superfamily
GSP_RS02990	COG4264	IucA IucC family
GSP_RS02995	COG3457	Alanine racemase
GSP_RS03000	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GSP_RS03005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GSP_RS03010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GSP_RS03015	COG3314	Sporulation integral membrane protein YlbJ
GSP_RS03025	COG1988	membrane-bound metal-dependent
GSP_RS03030	COG4284	Utp--glucose-1-phosphate uridylyltransferase
GSP_RS03035	COG1272	protein, Hemolysin III
GSP_RS03055	COG2814	Major facilitator Superfamily
GSP_RS03060	COG0489	protein tyrosine kinase activity
GSP_RS03125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GSP_RS03140	COG3711	transcriptional antiterminator
GSP_RS03170	COG1119	ATPase activity
GSP_RS03175	COG0561	phosphatase activity
GSP_RS03185	COG2186	Transcriptional regulator
GSP_RS03190	COG1482	cell wall glycoprotein biosynthetic process
GSP_RS03205	COG1757	Na H antiporter
GSP_RS03215	COG0813	purine-nucleoside phosphorylase activity
GSP_RS03250	COG5146	pantothenate kinase activity
GSP_RS03265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GSP_RS03275	COG0504	CTP synthase activity
GSP_RS03280	COG2271	Major facilitator Superfamily
GSP_RS03285	COG4821	SIS domain
GSP_RS03290	COG0191	fructose-bisphosphate aldolase activity
GSP_RS03295	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GSP_RS03300	COG1733	regulation of RNA biosynthetic process
GSP_RS03315	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GSP_RS03320	COG0254	rRNA binding
GSP_RS03330	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GSP_RS03335	COG2890	protein-(glutamine-N5) methyltransferase activity
GSP_RS03340	COG0009	L-threonylcarbamoyladenylate synthase
GSP_RS03345	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GSP_RS03350	COG4475	Protein of unknown function (DUF436)
GSP_RS03355	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GSP_RS03360	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GSP_RS03365	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GSP_RS03375	COG0356	it plays a direct role in the translocation of protons across the membrane
GSP_RS03380	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GSP_RS03390	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GSP_RS03400	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GSP_RS03430	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GSP_RS03445	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GSP_RS03455	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GSP_RS03460	COG0352	thiamine-phosphate diphosphorylase activity
GSP_RS03465	COG0706	membrane insertase activity
GSP_RS03470	COG1418	mRNA catabolic process
GSP_RS03475	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GSP_RS03480	COG1937	Protein conserved in bacteria
GSP_RS03495	COG2217	Heavy metal translocating P-type atpase
GSP_RS03505	COG0772	Belongs to the SEDS family
GSP_RS03510	COG1181	Belongs to the D-alanine--D-alanine ligase family
GSP_RS03515	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GSP_RS03520	COG0513	Belongs to the DEAD box helicase family
GSP_RS03535	COG3402	PFAM membrane-flanked domain
GSP_RS03540	COG0736	holo-[acyl-carrier-protein] synthase activity
GSP_RS03545	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GSP_RS03555	COG2337	Toxic component of a toxin-antitoxin (TA) module
GSP_RS03565	COG1366	Belongs to the anti-sigma-factor antagonist family
GSP_RS03575	COG1191	sigma factor activity
GSP_RS03580	COG2183	response to ionizing radiation
GSP_RS03585	COG3091	SprT-like family
GSP_RS03630	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GSP_RS03640	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GSP_RS03645	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GSP_RS03655	COG0028	Belongs to the TPP enzyme family
GSP_RS03660	COG0129	dihydroxy-acid dehydratase activity
GSP_RS03665	COG0802	atpase or kinase
GSP_RS03670	COG1214	PFAM Peptidase M22, glycoprotease
GSP_RS03675	COG0456	acetyltransferase
GSP_RS03680	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GSP_RS03690	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GSP_RS03695	COG0488	(ABC) transporter
GSP_RS03700	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GSP_RS03705	COG2814	Major facilitator Superfamily
GSP_RS03710	COG1846	Transcriptional regulator
GSP_RS03720	COG2124	cytochrome p450
GSP_RS03730	COG1609	Transcriptional regulator
GSP_RS03735	COG1621	beta-fructofuranosidase activity
GSP_RS03740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GSP_RS03760	COG4512	PFAM Accessory gene regulator B
GSP_RS03800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GSP_RS03805	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GSP_RS03825	COG1131	(ABC) transporter
GSP_RS03840	COG1070	Carbohydrate kinase
GSP_RS03845	COG2610	gluconate transmembrane transporter activity
GSP_RS03880	COG2706	6-phosphogluconolactonase activity
GSP_RS03885	COG1012	belongs to the aldehyde dehydrogenase family
GSP_RS03895	COG1227	inorganic diphosphatase activity
GSP_RS03900	COG1335	isochorismatase
GSP_RS03910	COG0077	Prephenate dehydratase
GSP_RS03920	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GSP_RS03930	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
GSP_RS03940	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GSP_RS03945	COG4496	protein, YerC YecD
GSP_RS03950	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
GSP_RS03955	COG0210	DNA helicase
GSP_RS03960	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GSP_RS03965	COG4851	CamS sex pheromone cAM373 precursor
GSP_RS03970	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GSP_RS03975	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GSP_RS03985	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GSP_RS03990	COG1597	lipid kinase activity
GSP_RS04015	COG0488	(ABC) transporter
GSP_RS04025	COG1396	sequence-specific DNA binding
GSP_RS04030	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GSP_RS04035	COG2211	Major facilitator Superfamily
GSP_RS04045	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GSP_RS04055	COG1528	Iron-storage protein
GSP_RS04070	COG4129	membrane
GSP_RS04075	COG0024	Methionine aminopeptidase
GSP_RS04100	COG0288	reversible hydration of carbon dioxide
GSP_RS04105	COG1295	ribonuclease BN
GSP_RS04120	COG4840	Belongs to the UPF0435 family
GSP_RS04125	COG2309	aminopeptidase activity
GSP_RS04130	COG1607	acyl-coa hydrolase
GSP_RS04135	COG0535	radical SAM domain protein
GSP_RS04140	COG0693	protein deglycase activity
GSP_RS04145	COG0028	Belongs to the TPP enzyme family
GSP_RS04150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GSP_RS04155	COG2137	regulation of response to DNA damage stimulus
GSP_RS04165	COG1134	teichoic acid transport
GSP_RS04165	COG1388	LysM domain
GSP_RS04175	COG1988	membrane-bound metal-dependent
GSP_RS04180	COG1194	a g-specific adenine glycosylase
GSP_RS04185	COG3557	Belongs to the UPF0374 family
GSP_RS04195	COG0069	glutamate synthase activity
GSP_RS04200	COG4129	membrane
GSP_RS04205	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GSP_RS04210	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GSP_RS04220	COG0735	belongs to the Fur family
GSP_RS04445	COG0765	amino acid transport
GSP_RS04450	COG1126	abc transporter atp-binding protein
GSP_RS04455	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GSP_RS04465	COG0363	glucosamine-6-phosphate deaminase activity
GSP_RS04475	COG0114	fumarate hydratase activity
GSP_RS04480	COG0248	Ppx GppA phosphatase
GSP_RS04485	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GSP_RS04490	COG0564	pseudouridine synthase activity
GSP_RS04495	COG2203	Gaf domain
GSP_RS04495	COG4585	Histidine kinase
GSP_RS04500	COG2197	response regulator
GSP_RS04510	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GSP_RS04525	COG4399	Belongs to the UPF0754 family
GSP_RS04530	COG3679	Belongs to the UPF0342 family
GSP_RS04535	COG0420	3'-5' exonuclease activity
GSP_RS04545	COG3481	metal-dependent phosphohydrolase, HD sub domain
GSP_RS04550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GSP_RS04565	COG1846	Transcriptional regulator
GSP_RS04575	COG0537	adenosine 5'-monophosphoramidase activity
GSP_RS04580	COG1131	(ABC) transporter
GSP_RS04585	COG4473	ABC transporter
GSP_RS04600	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GSP_RS04610	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GSP_RS04615	COG3545	Serine hydrolase
GSP_RS04705	COG3037	sugar-specific permease SgaT UlaA
GSP_RS04725	COG3623	hexulose-6-phosphate isomerase
GSP_RS04730	COG0235	Class ii aldolase
GSP_RS04750	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GSP_RS04755	COG0494	nUDIX hydrolase
GSP_RS04760	COG1506	peptidase
GSP_RS04765	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GSP_RS04770	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GSP_RS04780	COG0656	L-ascorbic acid biosynthetic process
GSP_RS04785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GSP_RS04790	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GSP_RS04800	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GSP_RS04825	COG4193	domain, Protein
GSP_RS04825	COG3266	domain, Protein
GSP_RS04825	COG5632	N-Acetylmuramoyl-L-alanine amidase
GSP_RS04835	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GSP_RS04835	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GSP_RS04840	COG0307	riboflavin synthase, alpha
GSP_RS04845	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GSP_RS04845	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GSP_RS04850	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GSP_RS04865	COG2267	carboxylic ester hydrolase activity
GSP_RS04870	COG0039	L-malate dehydrogenase activity
GSP_RS04880	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GSP_RS04885	COG1242	4 iron, 4 sulfur cluster binding
GSP_RS04890	COG2814	Major facilitator Superfamily
GSP_RS04895	COG0495	leucyl-tRNA aminoacylation
GSP_RS04900	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GSP_RS04905	COG2081	HI0933 family
GSP_RS04910	COG2244	polysaccharide biosynthetic process
GSP_RS04915	COG1187	pseudouridine synthase activity
GSP_RS04925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GSP_RS04930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GSP_RS04935	COG0510	thiamine kinase activity
GSP_RS04940	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GSP_RS04945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GSP_RS04955	COG1363	Peptidase, m42
GSP_RS04960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GSP_RS04965	COG4848	Belongs to the UPF0354 family
GSP_RS04970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GSP_RS04975	COG1674	ftsk spoiiie
GSP_RS04980	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GSP_RS04985	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
GSP_RS04995	COG1605	Chorismate mutase
GSP_RS04995	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GSP_RS05000	COG1609	Transcriptional regulator
GSP_RS05010	COG0454	-acetyltransferase
GSP_RS05015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GSP_RS05020	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GSP_RS05025	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GSP_RS05035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GSP_RS05040	COG0204	Acyl-transferase
GSP_RS05050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GSP_RS05055	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GSP_RS05060	COG1764	response to oxidative stress
GSP_RS05110	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GSP_RS05115	COG1956	GAF domain-containing protein
GSP_RS05120	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
GSP_RS05130	COG1104	cysteine desulfurase activity
GSP_RS05135	COG0301	tRNA thio-modification
GSP_RS05145	COG0616	signal peptide processing
GSP_RS05150	COG1714	RDD family
GSP_RS05155	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GSP_RS05160	COG0827	DNA restriction-modification system
GSP_RS05165	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GSP_RS05170	COG0589	response to stress
GSP_RS05175	COG0686	Belongs to the AlaDH PNT family
GSP_RS05185	COG0006	proline dipeptidase activity
GSP_RS05190	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GSP_RS05200	COG4109	DRTGG domain
GSP_RS05205	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GSP_RS05210	COG0587	DNA-directed DNA polymerase activity
GSP_RS05215	COG0281	malic enzyme
GSP_RS05220	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GSP_RS05225	COG0825	malonyl-CoA metabolic process
GSP_RS05230	COG0205	6-phosphofructokinase activity
GSP_RS05235	COG0469	pyruvate kinase activity
GSP_RS05240	COG0372	Belongs to the citrate synthase family
GSP_RS05245	COG0538	isocitrate dehydrogenase activity
GSP_RS05255	COG0745	RESPONSE REGULATOR receiver
GSP_RS05260	COG5002	protein histidine kinase activity
GSP_RS05265	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GSP_RS05265	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GSP_RS05275	COG0237	dephospho-CoA kinase activity
GSP_RS05290	COG3611	Membrane attachment protein
GSP_RS05295	COG1484	DNA-dependent DNA replication
GSP_RS05305	COG0833	amino acid
GSP_RS05310	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GSP_RS05315	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GSP_RS05320	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GSP_RS05335	COG0544	peptidyl-prolyl cis-trans isomerase activity
GSP_RS05345	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GSP_RS05350	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GSP_RS05360	COG0181	hydroxymethylbilane synthase activity
GSP_RS05375	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GSP_RS05390	COG2818	Glycosylase
GSP_RS05395	COG0525	valine-tRNA ligase activity
GSP_RS05400	COG0285	dihydrofolate synthase activity
GSP_RS05425	COG2868	ribosomal protein
GSP_RS05435	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GSP_RS05445	COG0632	four-way junction helicase activity
GSP_RS05450	COG2255	four-way junction helicase activity
GSP_RS05455	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GSP_RS05465	COG1862	Preprotein translocase
GSP_RS05470	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GSP_RS05470	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GSP_RS05475	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GSP_RS05475	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GSP_RS05480	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GSP_RS05490	COG1490	D-aminoacyl-tRNA deacylase activity
GSP_RS05495	COG0860	N-Acetylmuramoyl-L-alanine amidase
GSP_RS05505	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GSP_RS05515	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GSP_RS05520	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GSP_RS05525	COG1959	2 iron, 2 sulfur cluster binding
GSP_RS05540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GSP_RS05545	COG1104	cysteine desulfurase activity
GSP_RS05550	COG0482	sulfurtransferase activity
GSP_RS05560	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GSP_RS05565	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GSP_RS05570	COG4472	Bacterial protein of unknown function (DUF965)
GSP_RS05575	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GSP_RS05580	COG3906	Belongs to the UPF0473 family
GSP_RS05585	COG4122	O-methyltransferase activity
GSP_RS05590	COG0826	peptidase U32
GSP_RS05595	COG0826	peptidase U32
GSP_RS05600	COG0572	uridine kinase
GSP_RS05610	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GSP_RS05615	COG1984	allophanate hydrolase subunit 2
GSP_RS05620	COG0511	ligase activity, forming carbon-carbon bonds
GSP_RS05625	COG0439	Biotin carboxylase
GSP_RS05630	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GSP_RS05635	COG1914	H( )-stimulated, divalent metal cation uptake system
GSP_RS05640	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GSP_RS05645	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GSP_RS05650	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GSP_RS05655	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GSP_RS05660	COG1534	Rna-binding protein
GSP_RS05670	COG1713	HD superfamily hydrolase involved in NAD metabolism
GSP_RS05675	COG0799	negative regulation of ribosome biogenesis
GSP_RS05680	COG2226	methyltransferase
GSP_RS05685	COG1555	photosystem II stabilization
GSP_RS05685	COG1596	polysaccharide export
GSP_RS05690	COG2131	deaminase
GSP_RS05695	COG0658	competence protein
GSP_RS05695	COG2333	competence protein COMEC
GSP_RS05700	COG1466	dna polymerase III delta subunit
GSP_RS05705	COG0268	Binds directly to 16S ribosomal RNA
GSP_RS05715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GSP_RS05730	COG0443	Heat shock 70 kDa protein
GSP_RS05735	COG0484	heat shock protein binding
GSP_RS05740	COG2264	protein methyltransferase activity
GSP_RS05745	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GSP_RS05750	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GSP_RS05765	COG1030	water channel activity
GSP_RS05770	COG4864	UPF0365 protein
GSP_RS05780	COG1702	phosphate starvation-inducible protein PhoH
GSP_RS05790	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GSP_RS05800	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GSP_RS05805	COG1381	Involved in DNA repair and RecF pathway recombination
GSP_RS05810	COG0423	glycine-tRNA ligase activity
GSP_RS05815	COG0517	IMP dehydrogenase activity
GSP_RS05820	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GSP_RS05825	COG0358	DNA primase activity
GSP_RS05830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GSP_RS05835	COG2384	SAM-dependent methyltransferase
GSP_RS05840	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GSP_RS05845	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GSP_RS05850	COG0513	Belongs to the DEAD box helicase family
GSP_RS05855	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GSP_RS05860	COG1121	(ABC) transporter
GSP_RS05865	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GSP_RS05870	COG0735	belongs to the Fur family
GSP_RS05875	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GSP_RS05885	COG0768	penicillin binding
GSP_RS05890	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GSP_RS05895	COG0573	inorganic phosphate transmembrane transporter activity
GSP_RS05900	COG0581	inorganic phosphate transmembrane transporter activity
GSP_RS05905	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GSP_RS05910	COG0704	Plays a role in the regulation of phosphate uptake
GSP_RS05920	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GSP_RS05925	COG0457	Tetratricopeptide repeat
GSP_RS05925	COG0705	Rhomboid family
GSP_RS05930	COG4483	Protein conserved in bacteria
GSP_RS05935	COG1940	carbohydrate kinase activity
GSP_RS05940	COG0011	TIGRFAM Protein of
GSP_RS05945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GSP_RS05950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GSP_RS05980	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GSP_RS05985	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GSP_RS05995	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GSP_RS06000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GSP_RS06005	COG0095	Lipoate-protein ligase
GSP_RS06020	COG0006	proline dipeptidase activity
GSP_RS06025	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GSP_RS06030	COG0511	ligase activity, forming carbon-carbon bonds
GSP_RS06035	COG0439	Biotin carboxylase
GSP_RS06040	COG1302	Protein conserved in bacteria
GSP_RS06050	COG1570	exodeoxyribonuclease VII activity
GSP_RS06055	COG1722	exodeoxyribonuclease VII activity
GSP_RS06060	COG0142	geranyltranstransferase activity
GSP_RS06065	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GSP_RS06070	COG1438	arginine binding
GSP_RS06075	COG0497	DNA recombination
GSP_RS06080	COG0280	phosphate acetyltransferase
GSP_RS06085	COG3426	butyrate kinase activity
GSP_RS06090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GSP_RS06095	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GSP_RS06100	COG0022	dehydrogenase e1 component
GSP_RS06105	COG0508	dehydrogenase complex catalyzes the overall conversion of
GSP_RS06115	COG4129	membrane
GSP_RS06120	COG2195	Cleaves the N-terminal amino acid of tripeptides
GSP_RS06150	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GSP_RS06155	COG1234	tRNA 3'-trailer cleavage
GSP_RS06160	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GSP_RS06170	COG0667	Aldo Keto reductase
GSP_RS06175	COG0494	nUDIX hydrolase
GSP_RS06180	COG0735	belongs to the Fur family
GSP_RS06195	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GSP_RS06200	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GSP_RS06205	COG1187	pseudouridine synthase activity
GSP_RS06210	COG0745	RESPONSE REGULATOR receiver
GSP_RS06225	COG1141	Ferredoxin
GSP_RS06235	COG0514	ATP-dependent DNA helicase (RecQ)
GSP_RS06245	COG0492	ferredoxin-NADP+ reductase activity
GSP_RS06250	COG0252	asparaginase activity
GSP_RS06260	COG0539	negative regulation of cytoplasmic translation
GSP_RS06265	COG1160	GTP binding
GSP_RS06270	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GSP_RS06290	COG0142	geranyltranstransferase activity
GSP_RS06295	COG0105	UTP biosynthetic process
GSP_RS06305	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GSP_RS06315	COG0457	Tetratricopeptide repeat
GSP_RS06320	COG5582	Belongs to the UPF0302 family
GSP_RS06325	COG4347	Protein of unknown function (DUF1405)
GSP_RS06335	COG1694	Mazg nucleotide pyrophosphohydrolase
GSP_RS06340	COG0438	transferase activity, transferring glycosyl groups
GSP_RS06345	COG0617	tRNA 3'-terminal CCA addition
GSP_RS06360	COG0017	Asparaginyl-tRNA synthetase
GSP_RS06365	COG3935	DnaD domain protein
GSP_RS06370	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GSP_RS06380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GSP_RS06380	COG4499	WXG100 protein secretion system (Wss), protein YukC
GSP_RS06395	COG4474	Belongs to the UPF0398 family
GSP_RS06400	COG3599	regulation of cell shape
GSP_RS06410	COG0116	Belongs to the methyltransferase superfamily
GSP_RS06415	COG2962	Rard protein
GSP_RS06425	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GSP_RS06435	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GSP_RS06445	COG1413	lyase activity
GSP_RS06480	COG2190	(PTS) system
GSP_RS06490	COG0793	Belongs to the peptidase S41A family
GSP_RS06500	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GSP_RS06505	COG0671	phosphoesterase, PA-phosphatase related
GSP_RS06515	COG5002	protein histidine kinase activity
GSP_RS06520	COG0567	Dehydrogenase, E1 component
GSP_RS06545	COG0714	Associated with various cellular activities
GSP_RS06550	COG4548	von Willebrand factor, type A
GSP_RS06555	COG1114	Component of the transport system for branched-chain amino acids
GSP_RS06560	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GSP_RS06570	COG3853	Toxic anion resistance protein (TelA)
GSP_RS06590	COG1278	Cold shock
GSP_RS06610	COG1473	amidohydrolase
GSP_RS06615	COG2171	N-acyltransferase activity
GSP_RS06620	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GSP_RS06625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GSP_RS06630	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GSP_RS06635	COG0488	(ABC) transporter
GSP_RS06640	COG2996	Protein conserved in bacteria
GSP_RS06670	COG1363	Peptidase, m42
GSP_RS06675	COG0287	Prephenate dehydrogenase
GSP_RS06680	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GSP_RS06690	COG1942	4-Oxalocrotonate Tautomerase
GSP_RS06710	COG0628	permease
GSP_RS06720	COG3711	transcriptional antiterminator
GSP_RS06730	COG1115	amino acid carrier protein
GSP_RS06735	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GSP_RS06745	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GSP_RS06750	COG4841	protein insertion into membrane
GSP_RS06755	COG0824	Thioesterase
GSP_RS06765	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GSP_RS06770	COG1970	mechanosensitive ion channel activity
GSP_RS06775	COG0419	ATPase involved in DNA repair
GSP_RS06780	COG0420	3'-5' exonuclease activity
GSP_RS06785	COG3344	reverse transcriptase
GSP_RS06790	COG4846	Membrane protein involved in cytochrome C biogenesis
GSP_RS06795	COG3763	UPF0154 protein
GSP_RS06805	COG4224	UPF0291 protein
GSP_RS06815	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GSP_RS06825	COG0516	GMP reductase activity
GSP_RS06830	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GSP_RS06840	COG0833	amino acid
GSP_RS06855	COG0083	homoserine kinase activity
GSP_RS06860	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GSP_RS06865	COG0460	homoserine dehydrogenase
GSP_RS06870	COG0527	aspartate kinase activity
GSP_RS06890	COG1525	nuclease
GSP_RS06920	COG0584	glycerophosphoryl diester phosphodiesterase
GSP_RS06955	COG0789	Transcriptional regulator
GSP_RS06960	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
GSP_RS06965	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GSP_RS06970	COG0386	Belongs to the glutathione peroxidase family
GSP_RS06975	COG2267	carboxylic ester hydrolase activity
GSP_RS06980	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GSP_RS06985	COG1923	regulation of RNA biosynthetic process
GSP_RS06990	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GSP_RS07000	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GSP_RS07005	COG1619	proteins homologs of microcin C7 resistance protein MccF
GSP_RS07010	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
GSP_RS07015	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GSP_RS07035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GSP_RS07045	COG1013	pyruvate-flavodoxin oxidoreductase activity
GSP_RS07050	COG0674	pyruvate-flavodoxin oxidoreductase activity
GSP_RS07050	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GSP_RS07055	COG1692	metallophosphoesterase
GSP_RS07075	COG1418	mRNA catabolic process
GSP_RS07080	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GSP_RS07085	COG1546	Belongs to the CinA family
GSP_RS07085	COG1058	Belongs to the CinA family
GSP_RS07105	COG0300	oxidoreductase activity
GSP_RS07110	COG0612	Peptidase, M16
GSP_RS07115	COG0612	Peptidase, M16
GSP_RS07120	COG2188	Transcriptional regulator
GSP_RS07140	COG1185	polyribonucleotide nucleotidyltransferase activity
GSP_RS07150	COG0196	riboflavin kinase activity
GSP_RS07155	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GSP_RS07160	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GSP_RS07170	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GSP_RS07175	COG1358	cellular component organization or biogenesis
GSP_RS07180	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GSP_RS07185	COG0195	Participates in both transcription termination and antitermination
GSP_RS07190	COG0779	Required for maturation of 30S ribosomal subunits
GSP_RS07200	COG0442	prolyl-tRNA aminoacylation
GSP_RS07210	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GSP_RS07215	COG4589	Belongs to the CDS family
GSP_RS07220	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GSP_RS07225	COG0233	cytoplasmic translational termination
GSP_RS07230	COG0528	UMP kinase activity
GSP_RS07235	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GSP_RS07240	COG0052	Belongs to the universal ribosomal protein uS2 family
GSP_RS07245	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GSP_RS07250	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GSP_RS07255	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GSP_RS07260	COG4974	Belongs to the 'phage' integrase family
GSP_RS07265	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GSP_RS07270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GSP_RS07275	COG0758	DNA mediated transformation
GSP_RS07285	COG0045	succinate-CoA ligase (ADP-forming) activity
GSP_RS07295	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GSP_RS07310	COG4485	Bacterial membrane protein, YfhO
GSP_RS07350	COG0336	Belongs to the RNA methyltransferase TrmD family
GSP_RS07355	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GSP_RS07360	COG0228	four-way junction DNA binding
GSP_RS07370	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GSP_RS07415	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GSP_RS07420	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
GSP_RS07425	COG0552	protein localization to endoplasmic reticulum
GSP_RS07430	COG1196	nuclear chromosome segregation
GSP_RS07435	COG0571	ribonuclease III activity
GSP_RS07440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GSP_RS07455	COG0416	fatty acid biosynthetic process
GSP_RS07460	COG1349	DNA-binding transcription factor activity
GSP_RS07470	COG1760	l-serine dehydratase
GSP_RS07475	COG1760	l-serine dehydratase
GSP_RS07485	COG1302	Protein conserved in bacteria
GSP_RS07500	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GSP_RS07505	COG1162	GTPase activity
GSP_RS07510	COG2124	cytochrome p450
GSP_RS07525	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GSP_RS07530	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GSP_RS07530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GSP_RS07535	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GSP_RS07540	COG0242	peptide deformylase activity
GSP_RS07545	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GSP_RS07550	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GSP_RS07555	COG1758	RNA polymerase activity
GSP_RS07575	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GSP_RS07580	COG0284	orotidine-5'-phosphate decarboxylase activity
GSP_RS07585	COG0167	dihydroorotate dehydrogenase activity
GSP_RS07595	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GSP_RS07600	COG0505	Belongs to the CarA family
GSP_RS07620	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GSP_RS07625	COG0564	pseudouridine synthase activity
GSP_RS07630	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GSP_RS07635	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GSP_RS07640	COG3599	regulation of cell shape
GSP_RS07655	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GSP_RS07660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GSP_RS07670	COG4975	Glucose uptake
GSP_RS07675	COG1869	D-ribose catabolic process
GSP_RS07680	COG0762	integral membrane protein
GSP_RS07685	COG1799	cell septum assembly
GSP_RS07690	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GSP_RS07700	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GSP_RS07705	COG0849	cell division
GSP_RS07715	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GSP_RS07725	COG0768	penicillin binding
GSP_RS07730	COG4839	cell division protein FtsL
GSP_RS07735	COG0275	rRNA processing
GSP_RS07740	COG2001	Belongs to the MraZ family
GSP_RS07745	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
GSP_RS07750	COG0454	-acetyltransferase
GSP_RS07755	COG1011	Hydrolase
GSP_RS07770	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GSP_RS07830	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GSP_RS07835	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GSP_RS07840	COG1053	succinate dehydrogenase
GSP_RS07845	COG2009	succinate dehydrogenase
GSP_RS07850	COG0322	excinuclease ABC activity
GSP_RS07855	COG3118	belongs to the thioredoxin family
GSP_RS07860	COG1193	negative regulation of DNA recombination
GSP_RS07865	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GSP_RS07865	COG1796	DNA polymerase
GSP_RS07880	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GSP_RS07895	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GSP_RS07900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GSP_RS07905	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GSP_RS07925	COG0742	ribosomal rna small subunit methyltransferase
GSP_RS07935	COG4471	UPF0298 protein
GSP_RS07940	COG0584	glycerophosphoryl diester phosphodiesterase
GSP_RS07945	COG3679	Belongs to the UPF0342 family
GSP_RS07960	COG0109	protoheme IX farnesyltransferase activity
GSP_RS07980	COG0772	Belongs to the SEDS family
GSP_RS07985	COG4838	Belongs to the UPF0358 family
GSP_RS07990	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GSP_RS07995	COG4896	Protein conserved in bacteria
GSP_RS08000	COG1902	pentaerythritol trinitrate reductase activity
GSP_RS08005	COG1217	gtp-binding protein TYPA
GSP_RS08015	COG0483	inositol monophosphate 1-phosphatase activity
GSP_RS08020	COG4493	Belongs to the UPF0637 family
GSP_RS08035	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GSP_RS08040	COG1177	transmembrane transport
GSP_RS08050	COG3842	ATPase activity
GSP_RS08060	COG4476	Belongs to the UPF0223 family
GSP_RS08100	COG5503	Protein of unknown function (DUF1447)
GSP_RS08105	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GSP_RS08110	COG0569	domain protein
GSP_RS08115	COG1294	oxidase, subunit
GSP_RS08120	COG1271	oxidase subunit
GSP_RS08125	COG1393	Belongs to the ArsC family
GSP_RS08130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GSP_RS08135	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GSP_RS08145	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GSP_RS08160	COG4172	Belongs to the ABC transporter superfamily
GSP_RS08170	COG0151	Belongs to the GarS family
GSP_RS08175	COG0138	bifunctional purine biosynthesis protein purh
GSP_RS08185	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GSP_RS08190	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GSP_RS08200	COG0047	phosphoribosylformylglycinamidine synthase activity
GSP_RS08205	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GSP_RS08210	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GSP_RS08215	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GSP_RS08220	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GSP_RS08225	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GSP_RS08230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GSP_RS08230	COG1017	nitric oxide dioxygenase activity
GSP_RS08240	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GSP_RS08250	COG1845	cytochrome c oxidase, subunit III
GSP_RS08255	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GSP_RS08265	COG3973	AAA domain
GSP_RS08310	COG3212	peptidase
GSP_RS08325	COG1134	teichoic acid transport
GSP_RS08335	COG1682	transport, permease protein
GSP_RS08345	COG1215	transferase activity, transferring glycosyl groups
GSP_RS08355	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GSP_RS08360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GSP_RS08365	COG1316	TRANSCRIPTIONal
GSP_RS08390	COG3594	Acyltransferase
GSP_RS08395	COG0436	Aminotransferase
GSP_RS08400	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GSP_RS08410	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GSP_RS08415	COG1169	isochorismate synthase
GSP_RS08420	COG1575	Belongs to the MenA family. Type 1 subfamily
GSP_RS08425	COG0390	transport system, permease component
GSP_RS08430	COG4619	ABC transporter
GSP_RS08450	COG4873	Protein conserved in bacteria
GSP_RS08535	COG0456	acetyltransferase
GSP_RS08545	COG2226	methyltransferase
GSP_RS08595	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GSP_RS08605	COG4932	domain protein
GSP_RS08605	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
GSP_RS08605	COG3266	domain, Protein
GSP_RS08610	COG0737	Belongs to the 5'-nucleotidase family
GSP_RS08620	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GSP_RS08625	COG1696	Membrane protein involved in D-alanine export
GSP_RS08635	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
GSP_RS08640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GSP_RS08645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GSP_RS08650	COG0861	Integral membrane protein TerC family
GSP_RS08655	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GSP_RS08665	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GSP_RS08670	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GSP_RS08675	COG2814	Major facilitator Superfamily
GSP_RS08685	COG3715	PTS system
GSP_RS08690	COG3716	PTS system mannose fructose sorbose family IID component
GSP_RS08695	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GSP_RS08700	COG2382	esterase
GSP_RS08705	COG1115	amino acid carrier protein
GSP_RS08710	COG0628	permease
GSP_RS08715	COG4409	exo-alpha-(2->6)-sialidase activity
GSP_RS08720	COG2211	Major facilitator Superfamily
GSP_RS08725	COG0673	inositol 2-dehydrogenase activity
GSP_RS08735	COG0475	glutathione-regulated potassium exporter activity
GSP_RS08735	COG0569	domain protein
GSP_RS08740	COG2239	Acts as a magnesium transporter
GSP_RS08745	COG0564	pseudouridine synthase activity
GSP_RS08755	COG2357	RelA SpoT domain protein
GSP_RS08770	COG2346	COG2346, Truncated hemoglobins
GSP_RS08775	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GSP_RS08785	COG1164	Oligoendopeptidase f
GSP_RS08800	COG3591	Belongs to the peptidase S1B family
GSP_RS08810	COG1393	Belongs to the ArsC family
GSP_RS08815	COG0180	Tryptophanyl-tRNA synthetase
GSP_RS08820	COG4166	transmembrane transport
GSP_RS08825	COG4608	Belongs to the ABC transporter superfamily
GSP_RS08830	COG0444	Belongs to the ABC transporter superfamily
GSP_RS08835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GSP_RS08840	COG0601	transmembrane transport
GSP_RS08865	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
GSP_RS08885	COG0561	phosphatase activity
GSP_RS08890	COG0446	pyridine nucleotide-disulphide oxidoreductase
GSP_RS08895	COG3344	reverse transcriptase
GSP_RS08905	COG0179	Fumarylacetoacetate (FAA) hydrolase
GSP_RS08910	COG1074	ATP-dependent DNA helicase activity
GSP_RS08915	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GSP_RS08930	COG0166	Belongs to the GPI family
GSP_RS08935	COG0137	argininosuccinate synthase activity
GSP_RS08945	COG0584	glycerophosphoryl diester phosphodiesterase
GSP_RS08960	COG1012	belongs to the aldehyde dehydrogenase family
GSP_RS08965	COG1098	S1 RNA binding domain
GSP_RS08975	COG1278	Cold shock
GSP_RS08995	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GSP_RS09005	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GSP_RS09005	COG2111	Na H antiporter
GSP_RS09010	COG2111	Na H antiporter
GSP_RS09015	COG1006	Multisubunit Na H antiporter MnhC subunit
GSP_RS09020	COG0651	ATP synthesis coupled electron transport
GSP_RS09025	COG1863	multisubunit Na H antiporter MnhE subunit
GSP_RS09030	COG2212	antiporter activity
GSP_RS09035	COG1320	monovalent cation:proton antiporter activity
GSP_RS09045	COG2056	Na+-H+ antiporter family
GSP_RS09050	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GSP_RS09055	COG1252	NADH dehydrogenase
GSP_RS09060	COG0316	Belongs to the HesB IscA family
GSP_RS09065	COG4844	belongs to the
GSP_RS09070	COG1252	NADH dehydrogenase
GSP_RS09075	COG4837	Protein of unknown function (DUF1462)
GSP_RS09080	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GSP_RS09085	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GSP_RS09090	COG0647	UMP catabolic process
GSP_RS09095	COG2445	Protein of unknown function DUF86
GSP_RS09105	COG4470	Protein conserved in bacteria
GSP_RS09110	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GSP_RS09115	COG0737	Belongs to the 5'-nucleotidase family
GSP_RS09120	COG0730	response to heat
GSP_RS09125	COG1801	Protein of unknown function DUF72
GSP_RS09140	COG1253	flavin adenine dinucleotide binding
GSP_RS09150	COG0719	Fe-S assembly protein
GSP_RS09155	COG0822	iron-sulfur transferase activity
GSP_RS09165	COG0719	Fe-S assembly protein
GSP_RS09170	COG0396	ATPase activity
GSP_RS09180	COG1464	Belongs to the NlpA lipoprotein family
GSP_RS09185	COG1464	Belongs to the NlpA lipoprotein family
GSP_RS09190	COG2011	ABC-type metal ion transport system permease component
GSP_RS09200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GSP_RS09205	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GSP_RS09215	COG1393	Belongs to the ArsC family
GSP_RS09220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GSP_RS09230	COG0710	3-dehydroquinate dehydratase activity
GSP_RS09240	COG1764	response to oxidative stress
GSP_RS09255	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GSP_RS09275	COG0346	lactoylglutathione lyase activity
GSP_RS09305	COG0557	exoribonuclease II activity
GSP_RS09310	COG1647	Serine aminopeptidase, S33
GSP_RS09315	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GSP_RS09325	COG0148	phosphopyruvate hydratase activity
GSP_RS09330	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GSP_RS09335	COG0149	triose-phosphate isomerase activity
GSP_RS09340	COG0126	phosphoglycerate kinase activity
GSP_RS09365	COG1090	epimerase
GSP_RS09375	COG0740	serine-type endopeptidase activity
GSP_RS09390	COG1481	regulation of sporulation
GSP_RS09395	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GSP_RS09400	COG1660	Displays ATPase and GTPase activities
GSP_RS09415	COG0110	maltose O-acetyltransferase activity
GSP_RS09420	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GSP_RS09425	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GSP_RS09460	COG0653	protein targeting
GSP_RS09475	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GSP_RS09485	COG1739	Uncharacterized protein family UPF0029
GSP_RS09490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GSP_RS09510	COG2195	Cleaves the N-terminal amino acid of tripeptides
GSP_RS09515	COG1929	Belongs to the glycerate kinase type-1 family
GSP_RS09520	COG3118	belongs to the thioredoxin family
GSP_RS09535	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GSP_RS09545	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GSP_RS09550	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GSP_RS09580	COG3104	oligopeptide transport
GSP_RS09585	COG3104	oligopeptide transport
GSP_RS09600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GSP_RS09605	COG1174	glycine betaine transport
GSP_RS09610	COG0517	IMP dehydrogenase activity
GSP_RS09610	COG1125	glycine betaine transport
GSP_RS09615	COG0514	ATP-dependent DNA helicase (RecQ)
GSP_RS09620	COG0488	(ABC) transporter
GSP_RS09630	COG1368	sulfuric ester hydrolase activity
GSP_RS09640	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GSP_RS09660	COG0512	Glutamine amidotransferase of anthranilate synthase
GSP_RS09670	COG0720	synthase
GSP_RS09675	COG0602	queuosine metabolic process
GSP_RS09690	COG0463	Glycosyl transferase, family 2
GSP_RS09695	COG1253	flavin adenine dinucleotide binding
GSP_RS09700	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GSP_RS09700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GSP_RS09700	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GSP_RS09705	COG1105	Belongs to the carbohydrate kinase PfkB family
GSP_RS09710	COG1349	DNA-binding transcription factor activity
GSP_RS09730	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GSP_RS09735	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GSP_RS09760	COG0039	L-malate dehydrogenase activity
GSP_RS09780	COG4989	oxidoreductase activity
GSP_RS09785	COG0523	cobalamin synthesis protein
GSP_RS09800	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GSP_RS09805	COG4988	ABC transporter
GSP_RS09810	COG1968	undecaprenyl-diphosphatase activity
GSP_RS09820	COG1671	Belongs to the UPF0178 family
GSP_RS09825	COG1611	Belongs to the LOG family
GSP_RS09855	COG2839	Protein conserved in bacteria
GSP_RS09860	COG2814	Major facilitator Superfamily
GSP_RS09865	COG0583	DNA-binding transcription factor activity
GSP_RS09880	COG0217	transcriptional regulatory protein
GSP_RS09885	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GSP_RS09890	COG2022	thiamine diphosphate biosynthetic process
GSP_RS09900	COG0352	thiamine-phosphate diphosphorylase activity
GSP_RS09910	COG1388	LysM domain
GSP_RS09910	COG3942	CHAP domain
GSP_RS09915	COG0306	phosphate transporter
GSP_RS09920	COG1392	Phosphate transport regulator
GSP_RS09925	COG0577	efflux transmembrane transporter activity
GSP_RS09930	COG1136	(ABC) transporter
GSP_RS09940	COG0745	RESPONSE REGULATOR receiver
GSP_RS09945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GSP_RS09950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GSP_RS09960	COG3949	Membrane
GSP_RS09965	COG0477	Major facilitator Superfamily
GSP_RS09980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GSP_RS09985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GSP_RS09990	COG1120	ATPase activity
GSP_RS09995	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GSP_RS10000	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GSP_RS10020	COG1132	(ABC) transporter
GSP_RS10025	COG1686	Belongs to the peptidase S11 family
GSP_RS10040	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GSP_RS10045	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GSP_RS10050	COG1682	transport, permease protein
GSP_RS10060	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GSP_RS10075	COG1475	DNA binding
GSP_RS10080	COG0019	diaminopimelate decarboxylase activity
GSP_RS10090	COG4264	IucA IucC family
GSP_RS10095	COG4264	IucA IucC family
GSP_RS10100	COG2814	Major facilitator Superfamily
GSP_RS10105	COG4264	IucA IucC family
GSP_RS10110	COG2423	ornithine cyclodeaminase activity
GSP_RS10120	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GSP_RS10125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GSP_RS10130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GSP_RS10140	COG1121	(ABC) transporter
GSP_RS10145	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GSP_RS10150	COG0803	Belongs to the bacterial solute-binding protein 9 family
GSP_RS10155	COG1320	monovalent cation:proton antiporter activity
GSP_RS10160	COG2212	antiporter activity
GSP_RS10165	COG1863	multisubunit Na H antiporter MnhE subunit
GSP_RS10175	COG1006	Multisubunit Na H antiporter MnhC subunit
GSP_RS10180	COG2111	Na H antiporter
GSP_RS10185	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GSP_RS10185	COG2111	Na H antiporter
GSP_RS10235	COG0546	phosphoglycolate phosphatase activity
GSP_RS10240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GSP_RS10245	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GSP_RS10250	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GSP_RS10255	COG0805	protein transport
GSP_RS10260	COG0018	arginyl-trna synthetase
GSP_RS10275	COG1078	dGTPase activity
GSP_RS10285	COG4844	belongs to the
GSP_RS10340	COG0471	metal ion transport
GSP_RS10370	COG0280	phosphate acetyltransferase
GSP_RS10375	COG0095	Lipoate-protein ligase
GSP_RS10400	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GSP_RS10405	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GSP_RS10415	COG2814	Major facilitator Superfamily
GSP_RS10420	COG1566	PFAM secretion protein HlyD family protein
GSP_RS10430	COG2311	Membrane
GSP_RS10445	COG2363	Small membrane protein
GSP_RS10475	COG0183	Belongs to the thiolase family
GSP_RS10480	COG0318	PFAM AMP-dependent synthetase and ligase
GSP_RS10485	COG0588	phosphoglycerate mutase activity
GSP_RS10520	COG1131	(ABC) transporter
GSP_RS10525	COG1994	Peptidase M50
GSP_RS10530	COG0535	radical SAM domain protein
GSP_RS10555	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GSP_RS10560	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GSP_RS10570	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GSP_RS10585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GSP_RS10585	COG2190	(PTS) system
GSP_RS10585	COG1263	PTS System
GSP_RS10600	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GSP_RS10605	COG1469	GTP cyclohydrolase I activity
GSP_RS10610	COG1136	(ABC) transporter
GSP_RS10610	COG0577	efflux transmembrane transporter activity
GSP_RS10625	COG0561	phosphatase activity
GSP_RS10635	COG1428	Deoxynucleoside kinase
GSP_RS10640	COG1428	Deoxynucleoside kinase
GSP_RS10645	COG0546	phosphoglycolate phosphatase activity
GSP_RS10660	COG0488	(ABC) transporter
GSP_RS10675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GSP_RS10685	COG1473	amidohydrolase
GSP_RS10690	COG3527	Alpha-acetolactate decarboxylase
GSP_RS10695	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GSP_RS10700	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GSP_RS10705	COG0049	tRNA binding
GSP_RS10710	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GSP_RS10720	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GSP_RS10725	COG0085	RNA polymerase activity
GSP_RS10730	COG2813	Specifically methylates the guanine in position
GSP_RS10740	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GSP_RS10745	COG0081	regulation of translation
GSP_RS10750	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GSP_RS10755	COG0250	Participates in transcription elongation, termination and antitermination
GSP_RS10760	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GSP_RS10765	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GSP_RS10785	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
GSP_RS10790	COG0215	cysteine-tRNA ligase activity
GSP_RS10795	COG1045	serine acetyltransferase
GSP_RS10800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GSP_RS10810	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GSP_RS10815	COG4956	integral membrane protein (PIN domain superfamily)
GSP_RS10820	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GSP_RS10855	COG0542	response to heat
GSP_RS10860	COG3869	Catalyzes the specific phosphorylation of arginine residues in
GSP_RS10865	COG3880	PFAM UvrB UvrC protein
GSP_RS10875	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GSP_RS10885	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GSP_RS10890	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GSP_RS10895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GSP_RS10900	COG1289	transmembrane transporter activity
GSP_RS10970	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GSP_RS10975	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GSP_RS10985	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GSP_RS10995	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GSP_RS11000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GSP_RS11015	COG1098	S1 RNA binding domain
GSP_RS11025	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GSP_RS11030	COG3956	TIGRFAM MazG family protein
GSP_RS11035	COG2244	polysaccharide biosynthetic process
GSP_RS11040	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GSP_RS11045	COG0193	aminoacyl-tRNA hydrolase activity
GSP_RS11055	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GSP_RS11060	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GSP_RS11065	COG2088	sporulation resulting in formation of a cellular spore
GSP_RS11070	COG0251	oxidation-reduction process
GSP_RS11075	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GSP_RS11080	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GSP_RS11085	COG4466	Protein conserved in bacteria
GSP_RS11095	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GSP_RS11100	COG0084	hydrolase, TatD family'
GSP_RS11110	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GSP_RS11115	COG2827	Endonuclease containing a URI domain
GSP_RS11120	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GSP_RS11125	COG4467	Involved in initiation control of chromosome replication
GSP_RS11130	COG1774	PSP1 C-terminal conserved region
GSP_RS11135	COG0470	DNA polymerase III
GSP_RS11140	COG3870	Protein conserved in bacteria
GSP_RS11145	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GSP_RS11150	COG1982	Orn Lys Arg decarboxylase major
GSP_RS11170	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GSP_RS11175	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GSP_RS11180	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GSP_RS11185	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GSP_RS11195	COG2188	Transcriptional regulator
GSP_RS11200	COG0366	Alpha amylase catalytic
GSP_RS11205	COG1263	PTS System
GSP_RS11205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GSP_RS11215	COG0493	'glutamate synthase
GSP_RS11220	COG0067	glutamate synthase
GSP_RS11220	COG0070	glutamate synthase
GSP_RS11220	COG0069	glutamate synthase activity
GSP_RS11225	COG0583	DNA-binding transcription factor activity
GSP_RS11240	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GSP_RS11265	COG0626	cystathionine gamma-synthase activity
GSP_RS11270	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GSP_RS11275	COG2272	Belongs to the type-B carboxylesterase lipase family
GSP_RS11280	COG0733	neurotransmitter:sodium symporter activity
GSP_RS11290	COG0745	RESPONSE REGULATOR receiver
GSP_RS11295	COG2205	protein histidine kinase activity
GSP_RS11305	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GSP_RS11310	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GSP_RS11325	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GSP_RS11330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GSP_RS11330	COG0574	Belongs to the PEP-utilizing enzyme family
GSP_RS11350	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GSP_RS11360	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GSP_RS11370	COG1486	melibiose metabolic process
GSP_RS11375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GSP_RS11375	COG1263	PTS System
GSP_RS11395	COG2210	Belongs to the sulfur carrier protein TusA family
GSP_RS11400	COG1937	Protein conserved in bacteria
GSP_RS11405	COG0730	response to heat
GSP_RS11410	COG2814	Major facilitator Superfamily
GSP_RS11435	COG3682	Transcriptional regulator
GSP_RS11460	COG1124	(ABC) transporter
GSP_RS11465	COG0444	Belongs to the ABC transporter superfamily
GSP_RS11470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GSP_RS11475	COG0601	transmembrane transport
GSP_RS11480	COG0747	negative chemotaxis
GSP_RS11505	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GSP_RS11525	COG1525	nuclease
GSP_RS11560	COG0519	Catalyzes the synthesis of GMP from XMP
GSP_RS11560	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GSP_RS11565	COG0517	IMP dehydrogenase activity
GSP_RS11565	COG0516	GMP reductase activity
GSP_RS11570	COG2233	PERMEase
GSP_RS11575	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GSP_RS11590	COG5183	chlorophyll binding
GSP_RS11595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GSP_RS11600	COG1823	symporter activity
GSP_RS11605	COG0577	efflux transmembrane transporter activity
GSP_RS11605	COG1136	(ABC) transporter
GSP_RS11620	COG0778	Nitroreductase
GSP_RS11625	COG0450	alkyl hydroperoxide reductase
GSP_RS11640	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GSP_RS11650	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GSP_RS11655	COG2011	ABC-type metal ion transport system permease component
GSP_RS11660	COG1464	Belongs to the NlpA lipoprotein family
GSP_RS11665	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GSP_RS11670	COG0753	catalase activity
GSP_RS11680	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GSP_RS11690	COG0360	Binds together with S18 to 16S ribosomal RNA
GSP_RS11700	COG1668	transmembrane transport
GSP_RS11705	COG1131	(ABC) transporter
GSP_RS11710	COG0012	GTP binding
GSP_RS11720	COG0012	GTP binding
GSP_RS11725	COG4481	Protein conserved in bacteria
GSP_RS11730	COG0668	transmembrane transport
GSP_RS11735	COG1475	DNA binding
GSP_RS11740	COG0626	cystathionine gamma-synthase activity
GSP_RS11745	COG0626	cystathionine gamma-synthase activity
GSP_RS11750	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GSP_RS11750	COG0646	methionine synthase
GSP_RS11760	COG0829	nickel cation binding
GSP_RS11770	COG0830	nickel cation binding
GSP_RS11775	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
GSP_RS11785	COG2388	GCN5-related N-acetyl-transferase
GSP_RS11790	COG1846	Transcriptional regulator
GSP_RS11795	COG0346	lactoylglutathione lyase activity
GSP_RS11800	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GSP_RS11805	COG0400	carboxylic ester hydrolase activity
GSP_RS11830	COG0357	Ribosomal RNA small subunit methyltransferase G
GSP_RS11835	COG0445	tRNA wobble uridine modification
GSP_RS11840	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GSP_RS11845	COG0594	ribonuclease P activity