locus-tag	class	description
JC285_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JC285_RS00010	COG0592	DNA-directed DNA polymerase activity
JC285_RS00015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JC285_RS00015	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JC285_RS00020	COG2501	S4 domain
JC285_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JC285_RS00030	COG0187	DNA topoisomerase II activity
JC285_RS00040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JC285_RS00045	COG2986	histidine ammonia-lyase
JC285_RS00055	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
JC285_RS00065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JC285_RS00070	COG4241	membrane
JC285_RS00075	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
JC285_RS00080	COG0359	binds to the 23S rRNA
JC285_RS00085	COG0305	Participates in initiation and elongation during chromosome replication
JC285_RS00090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JC285_RS00095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JC285_RS00115	COG0745	RESPONSE REGULATOR receiver
JC285_RS00120	COG5002	protein histidine kinase activity
JC285_RS00125	COG4863	YycH protein
JC285_RS00135	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
JC285_RS00145	COG2801	Transposase and inactivated derivatives
JC285_RS00150	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
JC285_RS00240	COG3344	reverse transcriptase
JC285_RS00330	COG0531	amino acid
JC285_RS00335	COG2217	Heavy metal translocating P-type atpase
JC285_RS00360	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JC285_RS00370	COG0415	Belongs to the DNA photolyase family
JC285_RS00385	COG0702	epimerase
JC285_RS00390	COG2130	NADP-dependent
JC285_RS00405	COG3177	Filamentation induced by cAMP protein fic
JC285_RS00410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JC285_RS00420	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
JC285_RS00425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JC285_RS00445	COG2235	arginine
JC285_RS00460	COG2197	response regulator
JC285_RS00465	COG4585	Histidine kinase
JC285_RS00465	COG2203	Gaf domain
JC285_RS00470	COG0842	Transport permease protein
JC285_RS00475	COG1131	(ABC) transporter
JC285_RS00495	COG0431	NADPH-dependent FMN reductase
JC285_RS00510	COG0583	DNA-binding transcription factor activity
JC285_RS00515	COG1288	antiporter activity
JC285_RS00520	COG1473	amidohydrolase
JC285_RS00535	COG1353	crispr-associated protein
JC285_RS00540	COG1421	Csm2 Type III-A
JC285_RS00545	COG1337	RAMP superfamily
JC285_RS00550	COG1567	CRISPR-associated RAMP protein, Csm4 family
JC285_RS00555	COG1332	CRISPR-associated RAMP protein, Csm5 family
JC285_RS00570	COG2226	methyltransferase
JC285_RS00580	COG2508	Transcriptional regulator
JC285_RS00585	COG1953	Uracil, thiamine, allantoin
JC285_RS00590	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JC285_RS00605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JC285_RS00610	COG3257	ureidoglycine aminohydrolase activity
JC285_RS00615	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
JC285_RS00620	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
JC285_RS00625	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
JC285_RS00630	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
JC285_RS00645	COG2807	transmembrane transport
JC285_RS00670	COG0657	acetylesterase activity
JC285_RS00695	COG1609	Transcriptional regulator
JC285_RS00705	COG0673	inositol 2-dehydrogenase activity
JC285_RS00715	COG0366	Alpha amylase catalytic
JC285_RS00725	COG3833	ABC-type maltose transport systems, permease component
JC285_RS00730	COG1175	transmembrane transport
JC285_RS00740	COG3842	ATPase activity
JC285_RS00745	COG0475	glutathione-regulated potassium exporter activity
JC285_RS00750	COG0490	domain, Protein
JC285_RS00760	COG0346	lactoylglutathione lyase activity
JC285_RS00790	COG2814	Major facilitator Superfamily
JC285_RS00795	COG0367	asparagine synthase
JC285_RS00815	COG2850	peptidyl-arginine hydroxylation
JC285_RS00830	COG0366	Alpha amylase catalytic
JC285_RS00835	COG2188	Transcriptional regulator
JC285_RS00840	COG2222	sugar isomerase
JC285_RS00845	COG1105	Belongs to the carbohydrate kinase PfkB family
JC285_RS00860	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
JC285_RS00860	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JC285_RS00865	COG3715	PTS system
JC285_RS00870	COG3716	PTS system mannose fructose sorbose family IID component
JC285_RS00880	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JC285_RS00900	COG3314	Sporulation integral membrane protein YlbJ
JC285_RS00920	COG1063	alcohol dehydrogenase
JC285_RS00935	COG1620	l-lactate permease
JC285_RS00940	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
JC285_RS00945	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JC285_RS00950	COG0156	8-amino-7-oxononanoate synthase activity
JC285_RS00995	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
JC285_RS01010	COG0076	glutamate decarboxylase activity
JC285_RS01025	COG2318	DinB family
JC285_RS01030	COG0753	catalase activity
JC285_RS01040	COG0783	Belongs to the Dps family
JC285_RS01050	COG0436	Aminotransferase
JC285_RS01075	COG1136	(ABC) transporter
JC285_RS01085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JC285_RS01100	COG1755	Isoprenylcysteine carboxyl methyltransferase
JC285_RS01125	COG0579	oxidoreductase
JC285_RS01170	COG1073	alpha beta
JC285_RS01190	COG0438	transferase activity, transferring glycosyl groups
JC285_RS01195	COG0183	Belongs to the thiolase family
JC285_RS01210	COG0318	PFAM AMP-dependent synthetase and ligase
JC285_RS01220	COG2814	Major facilitator Superfamily
JC285_RS01230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JC285_RS01260	COG1609	Transcriptional regulator
JC285_RS01265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JC285_RS01270	COG1869	D-ribose catabolic process
JC285_RS01290	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JC285_RS01320	COG3711	transcriptional antiterminator
JC285_RS01325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JC285_RS01335	COG3037	sugar-specific permease SgaT UlaA
JC285_RS01345	COG1328	CTP reductase activity
JC285_RS01365	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JC285_RS01370	COG1942	4-Oxalocrotonate Tautomerase
JC285_RS01380	COG0803	Belongs to the bacterial solute-binding protein 9 family
JC285_RS01380	COG3443	Belongs to the bacterial solute-binding protein 9 family
JC285_RS01405	COG2207	Transcriptional regulator
JC285_RS01405	COG4753	response regulator
JC285_RS01410	COG2972	Histidine kinase
JC285_RS01420	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JC285_RS01425	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
JC285_RS01430	COG0477	Major facilitator Superfamily
JC285_RS01435	COG2211	Major facilitator Superfamily
JC285_RS01440	COG3250	beta-galactosidase activity
JC285_RS01445	COG1957	nucleoside hydrolase
JC285_RS01460	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
JC285_RS01465	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
JC285_RS01470	COG2807	transmembrane transport
JC285_RS01475	COG1396	sequence-specific DNA binding
JC285_RS01490	COG1785	Belongs to the alkaline phosphatase family
JC285_RS01495	COG0494	nUDIX hydrolase
JC285_RS01500	COG0556	nucleotide-excision repair
JC285_RS01515	COG1510	regulation of RNA biosynthetic process
JC285_RS01520	COG1012	belongs to the aldehyde dehydrogenase family
JC285_RS01525	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
JC285_RS01530	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JC285_RS01555	COG0107	imidazoleglycerol-phosphate synthase activity
JC285_RS01560	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JC285_RS01575	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JC285_RS01580	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JC285_RS01585	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JC285_RS01590	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
JC285_RS01625	COG2376	Dihydroxyacetone kinase
JC285_RS01630	COG1461	Dihydroxyacetone kinase
JC285_RS01635	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
JC285_RS01640	COG2824	Alkylphosphonate utilization operon protein PhnA
JC285_RS01645	COG1012	belongs to the aldehyde dehydrogenase family
JC285_RS01660	COG0596	Alpha beta hydrolase
JC285_RS01665	COG0789	Transcriptional regulator
JC285_RS01670	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JC285_RS01670	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JC285_RS01670	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JC285_RS01680	COG1705	Flagellar rod assembly protein muramidase FlgJ
JC285_RS01680	COG3942	CHAP domain
JC285_RS01690	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JC285_RS01695	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JC285_RS01700	COG0747	negative chemotaxis
JC285_RS01725	COG0463	Glycosyl transferase, family 2
JC285_RS01725	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JC285_RS01730	COG0463	Glycosyl transferase, family 2
JC285_RS01730	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JC285_RS01735	COG0438	transferase activity, transferring glycosyl groups
JC285_RS01740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JC285_RS01745	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JC285_RS01760	COG3181	Tripartite tricarboxylate transporter family receptor
JC285_RS01765	COG0778	Nitroreductase
JC285_RS01770	COG3001	Fructosamine kinase
JC285_RS01795	COG1136	(ABC) transporter
JC285_RS01800	COG0577	efflux transmembrane transporter activity
JC285_RS01820	COG4413	Urea transporter
JC285_RS01830	COG0832	Belongs to the urease beta subunit family
JC285_RS01835	COG0804	urea catabolic process
JC285_RS01840	COG0717	Belongs to the dCTP deaminase family
JC285_RS01845	COG0523	cobalamin synthesis protein
JC285_RS01855	COG1141	Ferredoxin
JC285_RS01880	COG0583	DNA-binding transcription factor activity
JC285_RS01890	COG1346	cytolysis
JC285_RS01905	COG1846	Transcriptional regulator
JC285_RS01910	COG0778	Nitroreductase
JC285_RS01915	COG2357	RelA SpoT domain protein
JC285_RS01955	COG1028	Short-chain dehydrogenase reductase Sdr
JC285_RS01970	COG3835	regulator
JC285_RS01975	COG2855	membrane
JC285_RS01980	COG3961	Belongs to the TPP enzyme family
JC285_RS01985	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JC285_RS01990	COG0512	Glutamine amidotransferase of anthranilate synthase
JC285_RS02000	COG0134	indole-3-glycerol-phosphate synthase activity
JC285_RS02010	COG0133	tryptophan synthase activity
JC285_RS02015	COG0159	tryptophan synthase activity
JC285_RS02035	COG0277	FAD linked oxidase domain protein
JC285_RS02040	COG0247	lactate metabolic process
JC285_RS02045	COG1132	(ABC) transporter
JC285_RS02050	COG1132	(ABC) transporter
JC285_RS02055	COG0789	Transcriptional regulator
JC285_RS02065	COG3871	stress protein (general stress protein 26)
JC285_RS02070	COG1115	amino acid carrier protein
JC285_RS02075	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
JC285_RS02080	COG2814	Major facilitator Superfamily
JC285_RS02085	COG2271	Major facilitator Superfamily
JC285_RS02090	COG3764	Sortase (surface protein transpeptidase)
JC285_RS02095	COG1929	Belongs to the glycerate kinase type-1 family
JC285_RS02105	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
JC285_RS02125	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JC285_RS02130	COG0702	epimerase
JC285_RS02135	COG4166	transmembrane transport
JC285_RS02140	COG0444	Belongs to the ABC transporter superfamily
JC285_RS02145	COG4608	Belongs to the ABC transporter superfamily
JC285_RS02150	COG0601	transmembrane transport
JC285_RS02155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JC285_RS02160	COG4166	transmembrane transport
JC285_RS02165	COG0444	Belongs to the ABC transporter superfamily
JC285_RS02170	COG4608	Belongs to the ABC transporter superfamily
JC285_RS02175	COG0601	transmembrane transport
JC285_RS02180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JC285_RS02190	COG1760	l-serine dehydratase
JC285_RS02195	COG1760	l-serine dehydratase
JC285_RS02225	COG0471	metal ion transport
JC285_RS02230	COG2116	formate transmembrane transporter activity
JC285_RS02240	COG0454	-acetyltransferase
JC285_RS02250	COG1648	precorrin-2 dehydrogenase activity
JC285_RS02250	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JC285_RS02255	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JC285_RS02260	COG2146	nitrite reductase [NAD(P)H] activity
JC285_RS02265	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JC285_RS02265	COG1648	precorrin-2 dehydrogenase activity
JC285_RS02270	COG0737	Belongs to the 5'-nucleotidase family
JC285_RS02280	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
JC285_RS02285	COG1140	nitrate reductase beta subunit
JC285_RS02295	COG2181	nitrate reductase activity
JC285_RS02305	COG4585	Histidine kinase
JC285_RS02310	COG2197	response regulator
JC285_RS02315	COG2223	nitrite transmembrane transporter activity
JC285_RS02320	COG3344	reverse transcriptase
JC285_RS02325	COG4187	Peptidase family M20/M25/M40
JC285_RS02335	COG0039	L-malate dehydrogenase activity
JC285_RS02340	COG1363	Peptidase, m42
JC285_RS02345	COG0697	spore germination
JC285_RS02355	COG2807	transmembrane transport
JC285_RS02365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JC285_RS02365	COG1263	PTS System
JC285_RS02380	COG1283	sodium-dependent phosphate transmembrane transporter activity
JC285_RS02400	COG0492	ferredoxin-NADP+ reductase activity
JC285_RS02405	COG2814	Major facilitator Superfamily
JC285_RS02410	COG0604	alcohol dehydrogenase
JC285_RS02425	COG1620	l-lactate permease
JC285_RS02430	COG0438	transferase activity, transferring glycosyl groups
JC285_RS02435	COG0579	oxidoreductase
JC285_RS02450	COG0577	efflux transmembrane transporter activity
JC285_RS02475	COG4640	response to antibiotic
JC285_RS02485	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
JC285_RS02495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JC285_RS02515	COG1304	FMN binding
JC285_RS02520	COG0523	cobalamin synthesis protein
JC285_RS02525	COG0786	glutamate:sodium symporter activity
JC285_RS02530	COG2207	Transcriptional regulator
JC285_RS02535	COG3250	beta-galactosidase activity
JC285_RS02555	COG1757	Na H antiporter
JC285_RS02560	COG2094	Belongs to the DNA glycosylase MPG family
JC285_RS02565	COG3152	Membrane
JC285_RS02570	COG4152	abc transporter atp-binding protein
JC285_RS02575	COG1668	transmembrane transport
JC285_RS02580	COG1742	UPF0060 membrane protein
JC285_RS02585	COG2017	converts alpha-aldose to the beta-anomer
JC285_RS02590	COG2258	MOSC domain
JC285_RS02595	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
JC285_RS02605	COG1266	CAAX protease self-immunity
JC285_RS02610	COG0583	DNA-binding transcription factor activity
JC285_RS02615	COG3314	Sporulation integral membrane protein YlbJ
JC285_RS02620	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
JC285_RS02625	COG1228	amidohydrolase
JC285_RS02630	COG0659	secondary active sulfate transmembrane transporter activity
JC285_RS02635	COG1473	amidohydrolase
JC285_RS02655	COG0385	Bile acid
JC285_RS02665	COG0346	lactoylglutathione lyase activity
JC285_RS02670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JC285_RS02695	COG1113	amino acid transport
JC285_RS02720	COG1316	TRANSCRIPTIONal
JC285_RS02735	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
JC285_RS02740	COG3383	formate dehydrogenase (NAD+) activity
JC285_RS02765	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JC285_RS02770	COG2076	Multidrug Resistance protein
JC285_RS02775	COG2076	Multidrug Resistance protein
JC285_RS02780	COG3942	CHAP domain
JC285_RS02790	COG1757	Na H antiporter
JC285_RS02800	COG3942	CHAP domain
JC285_RS02820	COG1960	acyl-CoA dehydrogenase activity
JC285_RS02825	COG2832	Protein of unknown function (DUF454)
JC285_RS02830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JC285_RS02835	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JC285_RS02845	COG2186	Transcriptional regulator
JC285_RS02855	COG1268	BioY protein
JC285_RS02870	COG1609	Transcriptional regulator
JC285_RS02875	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JC285_RS02880	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JC285_RS02885	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
JC285_RS02895	COG4149	molybdate abc transporter
JC285_RS02900	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
JC285_RS02905	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JC285_RS02910	COG0521	Mo-molybdopterin cofactor biosynthetic process
JC285_RS02930	COG0314	molybdopterin synthase activity
JC285_RS02940	COG0746	molybdenum cofactor guanylyltransferase activity
JC285_RS02945	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JC285_RS02970	COG2348	transferase activity, transferring amino-acyl groups
JC285_RS02975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JC285_RS02980	COG0436	Aminotransferase
JC285_RS03010	COG2252	PERMEase
JC285_RS03030	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JC285_RS03035	COG0088	Forms part of the polypeptide exit tunnel
JC285_RS03040	COG0089	rRNA binding
JC285_RS03045	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JC285_RS03050	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JC285_RS03055	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JC285_RS03060	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JC285_RS03065	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JC285_RS03070	COG0255	Belongs to the universal ribosomal protein uL29 family
JC285_RS03080	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JC285_RS03095	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JC285_RS03100	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JC285_RS03105	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JC285_RS03115	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JC285_RS03120	COG1841	ribosomal large subunit assembly
JC285_RS03130	COG0201	protein transport
JC285_RS03145	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JC285_RS03155	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JC285_RS03160	COG0202	RNA polymerase activity
JC285_RS03165	COG0203	ribosomal protein L17
JC285_RS03170	COG1122	ATPase activity
JC285_RS03175	COG1122	ATPase activity
JC285_RS03185	COG0101	tRNA pseudouridine synthase activity
JC285_RS03190	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JC285_RS03205	COG1335	isochorismatase
JC285_RS03210	COG1349	DNA-binding transcription factor activity
JC285_RS03225	COG3684	Belongs to the aldolase LacD family
JC285_RS03235	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JC285_RS03235	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JC285_RS03245	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
JC285_RS03250	COG1518	maintenance of DNA repeat elements
JC285_RS03270	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JC285_RS03285	COG1302	Protein conserved in bacteria
JC285_RS03290	COG2814	Major facilitator Superfamily
JC285_RS03295	COG4264	IucA IucC family
JC285_RS03300	COG2814	Major facilitator Superfamily
JC285_RS03305	COG4264	IucA IucC family
JC285_RS03310	COG3457	Alanine racemase
JC285_RS03315	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
JC285_RS03320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JC285_RS03325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JC285_RS03330	COG3314	Sporulation integral membrane protein YlbJ
JC285_RS03340	COG1988	membrane-bound metal-dependent
JC285_RS03345	COG4284	Utp--glucose-1-phosphate uridylyltransferase
JC285_RS03350	COG1272	protein, Hemolysin III
JC285_RS03370	COG2814	Major facilitator Superfamily
JC285_RS03375	COG0489	protein tyrosine kinase activity
JC285_RS03440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JC285_RS03455	COG3711	transcriptional antiterminator
JC285_RS03475	COG1119	ATPase activity
JC285_RS03480	COG0561	phosphatase activity
JC285_RS03490	COG2186	Transcriptional regulator
JC285_RS03495	COG1482	cell wall glycoprotein biosynthetic process
JC285_RS03510	COG1757	Na H antiporter
JC285_RS03520	COG0813	purine-nucleoside phosphorylase activity
JC285_RS03555	COG5146	pantothenate kinase activity
JC285_RS03570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JC285_RS03580	COG0504	CTP synthase activity
JC285_RS03585	COG2271	Major facilitator Superfamily
JC285_RS03590	COG4821	SIS domain
JC285_RS03595	COG0191	fructose-bisphosphate aldolase activity
JC285_RS03600	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JC285_RS03605	COG1733	regulation of RNA biosynthetic process
JC285_RS03620	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
JC285_RS03625	COG0254	rRNA binding
JC285_RS03635	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JC285_RS03640	COG2890	protein-(glutamine-N5) methyltransferase activity
JC285_RS03645	COG0009	L-threonylcarbamoyladenylate synthase
JC285_RS03650	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JC285_RS03655	COG4475	Protein of unknown function (DUF436)
JC285_RS03660	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JC285_RS03665	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JC285_RS03670	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
JC285_RS03680	COG0356	it plays a direct role in the translocation of protons across the membrane
JC285_RS03685	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JC285_RS03695	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JC285_RS03705	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JC285_RS03735	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JC285_RS03750	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
JC285_RS03760	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
JC285_RS03765	COG0352	thiamine-phosphate diphosphorylase activity
JC285_RS03770	COG0706	membrane insertase activity
JC285_RS03775	COG1418	mRNA catabolic process
JC285_RS03780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JC285_RS03785	COG1937	Protein conserved in bacteria
JC285_RS03800	COG2217	Heavy metal translocating P-type atpase
JC285_RS03820	COG0772	Belongs to the SEDS family
JC285_RS03825	COG1181	Belongs to the D-alanine--D-alanine ligase family
JC285_RS03830	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JC285_RS03835	COG0513	Belongs to the DEAD box helicase family
JC285_RS03850	COG3402	PFAM membrane-flanked domain
JC285_RS03855	COG0736	holo-[acyl-carrier-protein] synthase activity
JC285_RS03860	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JC285_RS03870	COG2337	Toxic component of a toxin-antitoxin (TA) module
JC285_RS03875	COG2208	phosphoserine phosphatase activity
JC285_RS03880	COG1366	Belongs to the anti-sigma-factor antagonist family
JC285_RS03890	COG1191	sigma factor activity
JC285_RS03895	COG2183	response to ionizing radiation
JC285_RS03900	COG3091	SprT-like family
JC285_RS03945	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JC285_RS03955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JC285_RS03960	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JC285_RS03970	COG0028	Belongs to the TPP enzyme family
JC285_RS03975	COG0129	dihydroxy-acid dehydratase activity
JC285_RS03980	COG0802	atpase or kinase
JC285_RS03985	COG1214	PFAM Peptidase M22, glycoprotease
JC285_RS03990	COG0456	acetyltransferase
JC285_RS03995	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JC285_RS04005	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JC285_RS04010	COG0488	(ABC) transporter
JC285_RS04015	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
JC285_RS04020	COG0425	Belongs to the sulfur carrier protein TusA family
JC285_RS04025	COG2391	methyltransferase activity
JC285_RS04030	COG1609	Transcriptional regulator
JC285_RS04035	COG1621	beta-fructofuranosidase activity
JC285_RS04040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JC285_RS04060	COG4512	PFAM Accessory gene regulator B
JC285_RS04105	COG1404	Belongs to the peptidase S8 family
JC285_RS04110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JC285_RS04115	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JC285_RS04135	COG1131	(ABC) transporter
JC285_RS04150	COG1070	Carbohydrate kinase
JC285_RS04155	COG2610	gluconate transmembrane transporter activity
JC285_RS04190	COG2706	6-phosphogluconolactonase activity
JC285_RS04195	COG1012	belongs to the aldehyde dehydrogenase family
JC285_RS04205	COG1227	inorganic diphosphatase activity
JC285_RS04210	COG1335	isochorismatase
JC285_RS04220	COG0077	Prephenate dehydratase
JC285_RS04220	COG1605	Chorismate mutase
JC285_RS04230	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
JC285_RS04240	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
JC285_RS04250	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JC285_RS04255	COG4496	protein, YerC YecD
JC285_RS04260	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
JC285_RS04265	COG0210	DNA helicase
JC285_RS04270	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JC285_RS04275	COG4851	CamS sex pheromone cAM373 precursor
JC285_RS04280	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JC285_RS04285	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JC285_RS04290	COG0154	amidase activity
JC285_RS04295	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JC285_RS04300	COG1597	lipid kinase activity
JC285_RS04310	COG1396	sequence-specific DNA binding
JC285_RS04315	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JC285_RS04320	COG2211	Major facilitator Superfamily
JC285_RS04330	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JC285_RS04340	COG1528	Iron-storage protein
JC285_RS04355	COG4129	membrane
JC285_RS04360	COG0024	Methionine aminopeptidase
JC285_RS04390	COG0288	reversible hydration of carbon dioxide
JC285_RS04395	COG1295	ribonuclease BN
JC285_RS04410	COG4840	Belongs to the UPF0435 family
JC285_RS04415	COG2309	aminopeptidase activity
JC285_RS04420	COG1607	acyl-coa hydrolase
JC285_RS04425	COG0535	radical SAM domain protein
JC285_RS04435	COG0693	protein deglycase activity
JC285_RS04440	COG0028	Belongs to the TPP enzyme family
JC285_RS04445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JC285_RS04450	COG2137	regulation of response to DNA damage stimulus
JC285_RS04460	COG1134	teichoic acid transport
JC285_RS04460	COG1388	LysM domain
JC285_RS04470	COG1988	membrane-bound metal-dependent
JC285_RS04475	COG1194	a g-specific adenine glycosylase
JC285_RS04480	COG3557	Belongs to the UPF0374 family
JC285_RS04490	COG0069	glutamate synthase activity
JC285_RS04495	COG4129	membrane
JC285_RS04500	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JC285_RS04505	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JC285_RS04515	COG0735	belongs to the Fur family
JC285_RS04735	COG0765	amino acid transport
JC285_RS04740	COG1126	abc transporter atp-binding protein
JC285_RS04745	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JC285_RS04755	COG0363	glucosamine-6-phosphate deaminase activity
JC285_RS04770	COG0114	fumarate hydratase activity
JC285_RS04775	COG0248	Ppx GppA phosphatase
JC285_RS04780	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
JC285_RS04785	COG0564	pseudouridine synthase activity
JC285_RS04790	COG4585	Histidine kinase
JC285_RS04790	COG2203	Gaf domain
JC285_RS04795	COG2197	response regulator
JC285_RS04805	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
JC285_RS04815	COG4399	Belongs to the UPF0754 family
JC285_RS04820	COG3679	Belongs to the UPF0342 family
JC285_RS04825	COG0420	3'-5' exonuclease activity
JC285_RS04835	COG3481	metal-dependent phosphohydrolase, HD sub domain
JC285_RS04840	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JC285_RS04855	COG1846	Transcriptional regulator
JC285_RS04865	COG0537	adenosine 5'-monophosphoramidase activity
JC285_RS04870	COG1131	(ABC) transporter
JC285_RS04875	COG4473	ABC transporter
JC285_RS04885	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JC285_RS04895	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
JC285_RS04900	COG3545	Serine hydrolase
JC285_RS04990	COG3037	sugar-specific permease SgaT UlaA
JC285_RS05010	COG3623	hexulose-6-phosphate isomerase
JC285_RS05015	COG0235	Class ii aldolase
JC285_RS05035	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
JC285_RS05040	COG0494	nUDIX hydrolase
JC285_RS05045	COG1506	peptidase
JC285_RS05050	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
JC285_RS05055	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JC285_RS05065	COG0656	L-ascorbic acid biosynthetic process
JC285_RS05070	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JC285_RS05075	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JC285_RS05085	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JC285_RS05110	COG3266	domain, Protein
JC285_RS05110	COG5632	N-Acetylmuramoyl-L-alanine amidase
JC285_RS05110	COG4193	domain, Protein
JC285_RS05120	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JC285_RS05120	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JC285_RS05125	COG0307	riboflavin synthase, alpha
JC285_RS05130	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JC285_RS05130	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JC285_RS05135	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
JC285_RS05150	COG2267	carboxylic ester hydrolase activity
JC285_RS05155	COG0039	L-malate dehydrogenase activity
JC285_RS05165	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
JC285_RS05170	COG1242	4 iron, 4 sulfur cluster binding
JC285_RS05175	COG2814	Major facilitator Superfamily
JC285_RS05180	COG0495	leucyl-tRNA aminoacylation
JC285_RS05185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JC285_RS05190	COG2081	HI0933 family
JC285_RS05195	COG2244	polysaccharide biosynthetic process
JC285_RS05200	COG1187	pseudouridine synthase activity
JC285_RS05210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JC285_RS05215	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JC285_RS05220	COG0510	thiamine kinase activity
JC285_RS05225	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JC285_RS05230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JC285_RS05240	COG1363	Peptidase, m42
JC285_RS05245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JC285_RS05250	COG4848	Belongs to the UPF0354 family
JC285_RS05255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JC285_RS05260	COG1674	ftsk spoiiie
JC285_RS05265	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JC285_RS05270	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
JC285_RS05280	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
JC285_RS05280	COG1605	Chorismate mutase
JC285_RS05285	COG1609	Transcriptional regulator
JC285_RS05295	COG0454	-acetyltransferase
JC285_RS05300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JC285_RS05305	COG2759	Belongs to the formate--tetrahydrofolate ligase family
JC285_RS05310	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
JC285_RS05320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JC285_RS05325	COG0204	Acyl-transferase
JC285_RS05335	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JC285_RS05340	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JC285_RS05345	COG1764	response to oxidative stress
JC285_RS05395	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JC285_RS05400	COG1956	GAF domain-containing protein
JC285_RS05405	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
JC285_RS05410	COG1104	cysteine desulfurase activity
JC285_RS05415	COG0301	tRNA thio-modification
JC285_RS05425	COG0616	signal peptide processing
JC285_RS05430	COG1714	RDD family
JC285_RS05435	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
JC285_RS05440	COG0827	DNA restriction-modification system
JC285_RS05445	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JC285_RS05450	COG0589	response to stress
JC285_RS05455	COG0686	Belongs to the AlaDH PNT family
JC285_RS05465	COG0006	proline dipeptidase activity
JC285_RS05470	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
JC285_RS05480	COG4109	DRTGG domain
JC285_RS05485	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
JC285_RS05490	COG0587	DNA-directed DNA polymerase activity
JC285_RS05495	COG0281	malic enzyme
JC285_RS05500	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JC285_RS05505	COG0825	malonyl-CoA metabolic process
JC285_RS05510	COG0205	6-phosphofructokinase activity
JC285_RS05515	COG0469	pyruvate kinase activity
JC285_RS05520	COG0372	Belongs to the citrate synthase family
JC285_RS05525	COG0538	isocitrate dehydrogenase activity
JC285_RS05530	COG0745	RESPONSE REGULATOR receiver
JC285_RS05535	COG5002	protein histidine kinase activity
JC285_RS05540	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JC285_RS05540	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JC285_RS05550	COG0237	dephospho-CoA kinase activity
JC285_RS05565	COG3611	Membrane attachment protein
JC285_RS05570	COG1484	DNA-dependent DNA replication
JC285_RS05580	COG0833	amino acid
JC285_RS05585	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JC285_RS05590	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JC285_RS05595	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
JC285_RS05610	COG0544	peptidyl-prolyl cis-trans isomerase activity
JC285_RS05620	COG0218	Necessary for normal cell division and for the maintenance of normal septation
JC285_RS05625	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JC285_RS05635	COG0181	hydroxymethylbilane synthase activity
JC285_RS05650	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JC285_RS05665	COG2818	Glycosylase
JC285_RS05670	COG0525	valine-tRNA ligase activity
JC285_RS05675	COG0285	dihydrofolate synthase activity
JC285_RS05685	COG2003	Belongs to the UPF0758 family
JC285_RS05725	COG2868	ribosomal protein
JC285_RS05735	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JC285_RS05745	COG0632	four-way junction helicase activity
JC285_RS05755	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
JC285_RS05765	COG1862	Preprotein translocase
JC285_RS05770	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JC285_RS05770	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JC285_RS05775	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
JC285_RS05775	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JC285_RS05780	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JC285_RS05790	COG1490	D-aminoacyl-tRNA deacylase activity
JC285_RS05795	COG0860	N-Acetylmuramoyl-L-alanine amidase
JC285_RS05805	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JC285_RS05815	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JC285_RS05825	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JC285_RS05830	COG1959	2 iron, 2 sulfur cluster binding
JC285_RS05845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JC285_RS05850	COG1104	cysteine desulfurase activity
JC285_RS05855	COG0482	sulfurtransferase activity
JC285_RS05865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JC285_RS05870	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JC285_RS05875	COG4472	Bacterial protein of unknown function (DUF965)
JC285_RS05880	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JC285_RS05885	COG3906	Belongs to the UPF0473 family
JC285_RS05890	COG4122	O-methyltransferase activity
JC285_RS05895	COG0826	peptidase U32
JC285_RS05900	COG0826	peptidase U32
JC285_RS05905	COG0572	uridine kinase
JC285_RS05915	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JC285_RS05920	COG1984	allophanate hydrolase subunit 2
JC285_RS05925	COG0511	ligase activity, forming carbon-carbon bonds
JC285_RS05930	COG0439	Biotin carboxylase
JC285_RS05935	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
JC285_RS05940	COG1914	H( )-stimulated, divalent metal cation uptake system
JC285_RS05945	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JC285_RS05950	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
JC285_RS05955	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
JC285_RS05960	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JC285_RS05965	COG1534	Rna-binding protein
JC285_RS05975	COG1713	HD superfamily hydrolase involved in NAD metabolism
JC285_RS05980	COG0799	negative regulation of ribosome biogenesis
JC285_RS05985	COG2226	methyltransferase
JC285_RS05990	COG1555	photosystem II stabilization
JC285_RS05990	COG1596	polysaccharide export
JC285_RS05995	COG2131	deaminase
JC285_RS06000	COG2333	competence protein COMEC
JC285_RS06000	COG0658	competence protein
JC285_RS06005	COG1466	dna polymerase III delta subunit
JC285_RS06010	COG0268	Binds directly to 16S ribosomal RNA
JC285_RS06020	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JC285_RS06035	COG0443	Heat shock 70 kDa protein
JC285_RS06040	COG0484	heat shock protein binding
JC285_RS06045	COG2264	protein methyltransferase activity
JC285_RS06050	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JC285_RS06055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JC285_RS06070	COG1030	water channel activity
JC285_RS06075	COG4864	UPF0365 protein
JC285_RS06085	COG1702	phosphate starvation-inducible protein PhoH
JC285_RS06095	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JC285_RS06105	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JC285_RS06110	COG1381	Involved in DNA repair and RecF pathway recombination
JC285_RS06115	COG0423	glycine-tRNA ligase activity
JC285_RS06120	COG0517	IMP dehydrogenase activity
JC285_RS06125	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JC285_RS06130	COG0358	DNA primase activity
JC285_RS06135	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JC285_RS06140	COG2384	SAM-dependent methyltransferase
JC285_RS06145	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JC285_RS06150	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JC285_RS06155	COG0513	Belongs to the DEAD box helicase family
JC285_RS06160	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
JC285_RS06165	COG1121	(ABC) transporter
JC285_RS06170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JC285_RS06175	COG0735	belongs to the Fur family
JC285_RS06180	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JC285_RS06190	COG0768	penicillin binding
JC285_RS06195	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JC285_RS06200	COG0573	inorganic phosphate transmembrane transporter activity
JC285_RS06205	COG0581	inorganic phosphate transmembrane transporter activity
JC285_RS06210	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JC285_RS06215	COG0704	Plays a role in the regulation of phosphate uptake
JC285_RS06225	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JC285_RS06230	COG0705	Rhomboid family
JC285_RS06230	COG0457	Tetratricopeptide repeat
JC285_RS06235	COG4483	Protein conserved in bacteria
JC285_RS06240	COG1940	carbohydrate kinase activity
JC285_RS06245	COG0011	TIGRFAM Protein of
JC285_RS06250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JC285_RS06255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JC285_RS06285	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JC285_RS06290	COG0404	The glycine cleavage system catalyzes the degradation of glycine
JC285_RS06300	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JC285_RS06305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JC285_RS06310	COG0095	Lipoate-protein ligase
JC285_RS06325	COG0006	proline dipeptidase activity
JC285_RS06330	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JC285_RS06335	COG0511	ligase activity, forming carbon-carbon bonds
JC285_RS06340	COG0439	Biotin carboxylase
JC285_RS06345	COG1302	Protein conserved in bacteria
JC285_RS06355	COG1570	exodeoxyribonuclease VII activity
JC285_RS06360	COG1722	exodeoxyribonuclease VII activity
JC285_RS06370	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JC285_RS06375	COG1438	arginine binding
JC285_RS06380	COG0497	DNA recombination
JC285_RS06385	COG0280	phosphate acetyltransferase
JC285_RS06390	COG3426	butyrate kinase activity
JC285_RS06395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JC285_RS06400	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
JC285_RS06405	COG0022	dehydrogenase e1 component
JC285_RS06410	COG0508	dehydrogenase complex catalyzes the overall conversion of
JC285_RS06420	COG4129	membrane
JC285_RS06430	COG2195	Cleaves the N-terminal amino acid of tripeptides
JC285_RS06460	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
JC285_RS06465	COG1234	tRNA 3'-trailer cleavage
JC285_RS06470	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JC285_RS06480	COG0667	Aldo Keto reductase
JC285_RS06485	COG0494	nUDIX hydrolase
JC285_RS06490	COG0735	belongs to the Fur family
JC285_RS06505	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
JC285_RS06510	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
JC285_RS06515	COG1187	pseudouridine synthase activity
JC285_RS06520	COG0745	RESPONSE REGULATOR receiver
JC285_RS06535	COG1141	Ferredoxin
JC285_RS06545	COG0514	ATP-dependent DNA helicase (RecQ)
JC285_RS06555	COG0492	ferredoxin-NADP+ reductase activity
JC285_RS06560	COG0252	asparaginase activity
JC285_RS06570	COG0539	negative regulation of cytoplasmic translation
JC285_RS06575	COG1160	GTP binding
JC285_RS06580	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JC285_RS06600	COG0142	geranyltranstransferase activity
JC285_RS06605	COG0105	UTP biosynthetic process
JC285_RS06615	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JC285_RS06625	COG0457	Tetratricopeptide repeat
JC285_RS06630	COG5582	Belongs to the UPF0302 family
JC285_RS06635	COG4347	Protein of unknown function (DUF1405)
JC285_RS06645	COG1694	Mazg nucleotide pyrophosphohydrolase
JC285_RS06650	COG0438	transferase activity, transferring glycosyl groups
JC285_RS06655	COG0617	tRNA 3'-terminal CCA addition
JC285_RS06670	COG0017	Asparaginyl-tRNA synthetase
JC285_RS06675	COG3935	DnaD domain protein
JC285_RS06680	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JC285_RS06690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JC285_RS06690	COG4499	WXG100 protein secretion system (Wss), protein YukC
JC285_RS06705	COG4474	Belongs to the UPF0398 family
JC285_RS06710	COG3599	regulation of cell shape
JC285_RS06720	COG0116	Belongs to the methyltransferase superfamily
JC285_RS06725	COG2962	Rard protein
JC285_RS06730	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
JC285_RS06735	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JC285_RS06745	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
JC285_RS06790	COG2190	(PTS) system
JC285_RS06800	COG0793	Belongs to the peptidase S41A family
JC285_RS06810	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JC285_RS06815	COG0671	phosphoesterase, PA-phosphatase related
JC285_RS06825	COG5002	protein histidine kinase activity
JC285_RS06830	COG0567	Dehydrogenase, E1 component
JC285_RS06855	COG0714	Associated with various cellular activities
JC285_RS06860	COG4548	von Willebrand factor, type A
JC285_RS06865	COG1114	Component of the transport system for branched-chain amino acids
JC285_RS06870	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JC285_RS06875	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JC285_RS06880	COG3853	Toxic anion resistance protein (TelA)
JC285_RS06900	COG1278	Cold shock
JC285_RS06920	COG1473	amidohydrolase
JC285_RS06925	COG2171	N-acyltransferase activity
JC285_RS06930	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JC285_RS06935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JC285_RS06940	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JC285_RS06945	COG0488	(ABC) transporter
JC285_RS06950	COG2996	Protein conserved in bacteria
JC285_RS06980	COG1363	Peptidase, m42
JC285_RS06985	COG0287	Prephenate dehydrogenase
JC285_RS06990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JC285_RS07000	COG1942	4-Oxalocrotonate Tautomerase
JC285_RS07020	COG0628	permease
JC285_RS07030	COG3711	transcriptional antiterminator
JC285_RS07035	COG1115	amino acid carrier protein
JC285_RS07040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JC285_RS07050	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
JC285_RS07055	COG4841	protein insertion into membrane
JC285_RS07060	COG0824	Thioesterase
JC285_RS07070	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JC285_RS07075	COG1970	mechanosensitive ion channel activity
JC285_RS07080	COG0419	ATPase involved in DNA repair
JC285_RS07085	COG0420	3'-5' exonuclease activity
JC285_RS07090	COG4846	Membrane protein involved in cytochrome C biogenesis
JC285_RS07095	COG3763	UPF0154 protein
JC285_RS07105	COG4224	UPF0291 protein
JC285_RS07115	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JC285_RS07125	COG0516	GMP reductase activity
JC285_RS07130	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JC285_RS07140	COG0833	amino acid
JC285_RS07155	COG0083	homoserine kinase activity
JC285_RS07160	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JC285_RS07165	COG0460	homoserine dehydrogenase
JC285_RS07170	COG0527	aspartate kinase activity
JC285_RS07190	COG1525	nuclease
JC285_RS07220	COG0584	glycerophosphoryl diester phosphodiesterase
JC285_RS07245	COG0789	Transcriptional regulator
JC285_RS07250	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
JC285_RS07255	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JC285_RS07260	COG0386	Belongs to the glutathione peroxidase family
JC285_RS07265	COG2267	carboxylic ester hydrolase activity
JC285_RS07270	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JC285_RS07275	COG1923	regulation of RNA biosynthetic process
JC285_RS07280	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JC285_RS07290	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JC285_RS07295	COG1619	proteins homologs of microcin C7 resistance protein MccF
JC285_RS07300	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
JC285_RS07305	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
JC285_RS07325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JC285_RS07335	COG1013	pyruvate-flavodoxin oxidoreductase activity
JC285_RS07340	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JC285_RS07340	COG0674	pyruvate-flavodoxin oxidoreductase activity
JC285_RS07345	COG1692	metallophosphoesterase
JC285_RS07365	COG1418	mRNA catabolic process
JC285_RS07370	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JC285_RS07375	COG1546	Belongs to the CinA family
JC285_RS07375	COG1058	Belongs to the CinA family
JC285_RS07395	COG0300	oxidoreductase activity
JC285_RS07400	COG0612	Peptidase, M16
JC285_RS07405	COG0612	Peptidase, M16
JC285_RS07410	COG2188	Transcriptional regulator
JC285_RS07425	COG1185	polyribonucleotide nucleotidyltransferase activity
JC285_RS07435	COG0196	riboflavin kinase activity
JC285_RS07440	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JC285_RS07445	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JC285_RS07455	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JC285_RS07460	COG1358	cellular component organization or biogenesis
JC285_RS07465	COG2740	Nucleic-acid-binding protein implicated in transcription termination
JC285_RS07470	COG0195	Participates in both transcription termination and antitermination
JC285_RS07475	COG0779	Required for maturation of 30S ribosomal subunits
JC285_RS07485	COG0442	prolyl-tRNA aminoacylation
JC285_RS07495	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
JC285_RS07500	COG4589	Belongs to the CDS family
JC285_RS07510	COG0233	cytoplasmic translational termination
JC285_RS07515	COG0528	UMP kinase activity
JC285_RS07520	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JC285_RS07525	COG0052	Belongs to the universal ribosomal protein uS2 family
JC285_RS07530	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
JC285_RS07535	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
JC285_RS07540	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
JC285_RS07545	COG4974	Belongs to the 'phage' integrase family
JC285_RS07550	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
JC285_RS07555	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JC285_RS07560	COG0758	DNA mediated transformation
JC285_RS07570	COG0045	succinate-CoA ligase (ADP-forming) activity
JC285_RS07580	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JC285_RS07595	COG4485	Bacterial membrane protein, YfhO
JC285_RS07635	COG0336	Belongs to the RNA methyltransferase TrmD family
JC285_RS07640	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JC285_RS07645	COG0228	four-way junction DNA binding
JC285_RS07660	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JC285_RS07665	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
JC285_RS07670	COG0552	protein localization to endoplasmic reticulum
JC285_RS07675	COG1196	nuclear chromosome segregation
JC285_RS07680	COG0571	ribonuclease III activity
JC285_RS07685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JC285_RS07700	COG0416	fatty acid biosynthetic process
JC285_RS07705	COG1349	DNA-binding transcription factor activity
JC285_RS07715	COG1760	l-serine dehydratase
JC285_RS07720	COG1760	l-serine dehydratase
JC285_RS07730	COG1302	Protein conserved in bacteria
JC285_RS07745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JC285_RS07750	COG1162	GTPase activity
JC285_RS07760	COG2124	cytochrome p450
JC285_RS07775	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JC285_RS07780	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JC285_RS07780	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JC285_RS07785	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JC285_RS07790	COG0242	peptide deformylase activity
JC285_RS07795	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JC285_RS07800	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JC285_RS07805	COG1758	RNA polymerase activity
JC285_RS07825	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JC285_RS07830	COG0284	orotidine-5'-phosphate decarboxylase activity
JC285_RS07835	COG0167	dihydroorotate dehydrogenase activity
JC285_RS07845	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JC285_RS07850	COG0505	Belongs to the CarA family
JC285_RS07870	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
JC285_RS07875	COG0564	pseudouridine synthase activity
JC285_RS07880	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JC285_RS07885	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JC285_RS07890	COG3599	regulation of cell shape
JC285_RS07900	COG0673	inositol 2-dehydrogenase activity
JC285_RS07905	COG4409	exo-alpha-(2->6)-sialidase activity
JC285_RS07915	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JC285_RS07920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JC285_RS07930	COG4975	Glucose uptake
JC285_RS07935	COG1869	D-ribose catabolic process
JC285_RS07940	COG0762	integral membrane protein
JC285_RS07945	COG1799	cell septum assembly
JC285_RS07950	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JC285_RS07960	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JC285_RS07965	COG0849	cell division
JC285_RS07975	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JC285_RS07985	COG0768	penicillin binding
JC285_RS07990	COG4839	cell division protein FtsL
JC285_RS07995	COG0275	rRNA processing
JC285_RS08000	COG2001	Belongs to the MraZ family
JC285_RS08005	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
JC285_RS08010	COG0454	-acetyltransferase
JC285_RS08015	COG1011	Hydrolase
JC285_RS08030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JC285_RS08060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JC285_RS08065	COG0783	Belongs to the Dps family
JC285_RS08120	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JC285_RS08125	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JC285_RS08130	COG1053	succinate dehydrogenase
JC285_RS08135	COG2009	succinate dehydrogenase
JC285_RS08140	COG0322	excinuclease ABC activity
JC285_RS08145	COG3118	belongs to the thioredoxin family
JC285_RS08150	COG1193	negative regulation of DNA recombination
JC285_RS08155	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JC285_RS08155	COG1796	DNA polymerase
JC285_RS08170	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JC285_RS08185	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JC285_RS08190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JC285_RS08195	COG0333	Belongs to the bacterial ribosomal protein bL32 family
JC285_RS08215	COG0742	ribosomal rna small subunit methyltransferase
JC285_RS08225	COG4471	UPF0298 protein
JC285_RS08230	COG0584	glycerophosphoryl diester phosphodiesterase
JC285_RS08235	COG3679	Belongs to the UPF0342 family
JC285_RS08250	COG0109	protoheme IX farnesyltransferase activity
JC285_RS08265	COG3344	reverse transcriptase
JC285_RS08270	COG0772	Belongs to the SEDS family
JC285_RS08275	COG4838	Belongs to the UPF0358 family
JC285_RS08280	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
JC285_RS08285	COG4896	Protein conserved in bacteria
JC285_RS08290	COG1902	pentaerythritol trinitrate reductase activity
JC285_RS08295	COG1217	gtp-binding protein TYPA
JC285_RS08305	COG0483	inositol monophosphate 1-phosphatase activity
JC285_RS08310	COG4493	Belongs to the UPF0637 family
JC285_RS08325	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
JC285_RS08330	COG1177	transmembrane transport
JC285_RS08340	COG3842	ATPase activity
JC285_RS08350	COG4476	Belongs to the UPF0223 family
JC285_RS08390	COG5503	Protein of unknown function (DUF1447)
JC285_RS08395	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
JC285_RS08400	COG0569	domain protein
JC285_RS08405	COG1294	oxidase, subunit
JC285_RS08410	COG1271	oxidase subunit
JC285_RS08415	COG1393	Belongs to the ArsC family
JC285_RS08420	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JC285_RS08425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JC285_RS08435	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JC285_RS08455	COG4172	Belongs to the ABC transporter superfamily
JC285_RS08465	COG0151	Belongs to the GarS family
JC285_RS08470	COG0138	bifunctional purine biosynthesis protein purh
JC285_RS08480	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JC285_RS08485	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
JC285_RS08495	COG0047	phosphoribosylformylglycinamidine synthase activity
JC285_RS08500	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JC285_RS08505	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JC285_RS08510	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
JC285_RS08515	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JC285_RS08520	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JC285_RS08525	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JC285_RS08525	COG1017	nitric oxide dioxygenase activity
JC285_RS08535	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JC285_RS08545	COG1845	cytochrome c oxidase, subunit III
JC285_RS08550	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
JC285_RS08560	COG3973	AAA domain
JC285_RS08575	COG3212	peptidase
JC285_RS08590	COG1134	teichoic acid transport
JC285_RS08600	COG1682	transport, permease protein
JC285_RS08610	COG1215	transferase activity, transferring glycosyl groups
JC285_RS08620	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
JC285_RS08650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JC285_RS08655	COG1316	TRANSCRIPTIONal
JC285_RS08680	COG3594	Acyltransferase
JC285_RS08685	COG0436	Aminotransferase
JC285_RS08690	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
JC285_RS08700	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
JC285_RS08705	COG1169	isochorismate synthase
JC285_RS08710	COG1575	Belongs to the MenA family. Type 1 subfamily
JC285_RS08715	COG0390	transport system, permease component
JC285_RS08720	COG4619	ABC transporter
JC285_RS08740	COG4873	Protein conserved in bacteria
JC285_RS08800	COG4932	domain protein
JC285_RS08800	COG3266	domain, Protein
JC285_RS08800	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
JC285_RS08805	COG0737	Belongs to the 5'-nucleotidase family
JC285_RS08815	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JC285_RS08820	COG1696	Membrane protein involved in D-alanine export
JC285_RS08830	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
JC285_RS08840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JC285_RS08845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JC285_RS08850	COG0861	Integral membrane protein TerC family
JC285_RS08855	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
JC285_RS08865	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JC285_RS08870	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JC285_RS08875	COG2814	Major facilitator Superfamily
JC285_RS08885	COG3715	PTS system
JC285_RS08890	COG3716	PTS system mannose fructose sorbose family IID component
JC285_RS08895	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
JC285_RS08900	COG2382	esterase
JC285_RS08905	COG1115	amino acid carrier protein
JC285_RS08910	COG0628	permease
JC285_RS08920	COG0569	domain protein
JC285_RS08920	COG0475	glutathione-regulated potassium exporter activity
JC285_RS08925	COG2239	Acts as a magnesium transporter
JC285_RS08930	COG0564	pseudouridine synthase activity
JC285_RS08940	COG2357	RelA SpoT domain protein
JC285_RS08955	COG2346	COG2346, Truncated hemoglobins
JC285_RS08960	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
JC285_RS08970	COG1164	Oligoendopeptidase f
JC285_RS08985	COG3591	Belongs to the peptidase S1B family
JC285_RS08995	COG1393	Belongs to the ArsC family
JC285_RS09000	COG0180	Tryptophanyl-tRNA synthetase
JC285_RS09005	COG4166	transmembrane transport
JC285_RS09010	COG4608	Belongs to the ABC transporter superfamily
JC285_RS09015	COG0444	Belongs to the ABC transporter superfamily
JC285_RS09020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JC285_RS09025	COG0601	transmembrane transport
JC285_RS09050	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
JC285_RS09070	COG0561	phosphatase activity
JC285_RS09075	COG0446	pyridine nucleotide-disulphide oxidoreductase
JC285_RS09085	COG0179	Fumarylacetoacetate (FAA) hydrolase
JC285_RS09095	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
JC285_RS09110	COG0166	Belongs to the GPI family
JC285_RS09115	COG0137	argininosuccinate synthase activity
JC285_RS09125	COG0584	glycerophosphoryl diester phosphodiesterase
JC285_RS09140	COG1012	belongs to the aldehyde dehydrogenase family
JC285_RS09145	COG1098	S1 RNA binding domain
JC285_RS09155	COG1278	Cold shock
JC285_RS09175	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JC285_RS09185	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JC285_RS09185	COG2111	Na H antiporter
JC285_RS09190	COG2111	Na H antiporter
JC285_RS09195	COG1006	Multisubunit Na H antiporter MnhC subunit
JC285_RS09200	COG0651	ATP synthesis coupled electron transport
JC285_RS09205	COG1863	multisubunit Na H antiporter MnhE subunit
JC285_RS09210	COG2212	antiporter activity
JC285_RS09215	COG1320	monovalent cation:proton antiporter activity
JC285_RS09225	COG2056	Na+-H+ antiporter family
JC285_RS09230	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JC285_RS09235	COG1252	NADH dehydrogenase
JC285_RS09240	COG0316	Belongs to the HesB IscA family
JC285_RS09245	COG4844	belongs to the
JC285_RS09250	COG1252	NADH dehydrogenase
JC285_RS09255	COG4837	Protein of unknown function (DUF1462)
JC285_RS09260	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
JC285_RS09265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JC285_RS09270	COG0647	UMP catabolic process
JC285_RS09275	COG2445	Protein of unknown function DUF86
JC285_RS09285	COG4470	Protein conserved in bacteria
JC285_RS09290	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JC285_RS09295	COG0737	Belongs to the 5'-nucleotidase family
JC285_RS09300	COG0730	response to heat
JC285_RS09305	COG1801	Protein of unknown function DUF72
JC285_RS09320	COG1253	flavin adenine dinucleotide binding
JC285_RS09450	COG1783	phage Terminase large subunit
JC285_RS09455	COG3728	DNA packaging
JC285_RS09455	COG5484	DNA packaging
JC285_RS09545	COG1484	DNA-dependent DNA replication
JC285_RS09595	COG3617	BRO family, N-terminal domain
JC285_RS09615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JC285_RS09635	COG0719	Fe-S assembly protein
JC285_RS09640	COG0822	iron-sulfur transferase activity
JC285_RS09650	COG0719	Fe-S assembly protein
JC285_RS09655	COG0396	ATPase activity
JC285_RS09665	COG1464	Belongs to the NlpA lipoprotein family
JC285_RS09670	COG1464	Belongs to the NlpA lipoprotein family
JC285_RS09675	COG2011	ABC-type metal ion transport system permease component
JC285_RS09680	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JC285_RS09685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JC285_RS09690	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
JC285_RS09700	COG1393	Belongs to the ArsC family
JC285_RS09705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JC285_RS09715	COG0710	3-dehydroquinate dehydratase activity
JC285_RS09725	COG1764	response to oxidative stress
JC285_RS09740	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JC285_RS09760	COG0346	lactoylglutathione lyase activity
JC285_RS09790	COG0557	exoribonuclease II activity
JC285_RS09795	COG1647	Serine aminopeptidase, S33
JC285_RS09800	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JC285_RS09810	COG0148	phosphopyruvate hydratase activity
JC285_RS09815	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
JC285_RS09845	COG1090	epimerase
JC285_RS09855	COG0740	serine-type endopeptidase activity
JC285_RS09865	COG1481	regulation of sporulation
JC285_RS09870	COG0391	Required for morphogenesis under gluconeogenic growth conditions
JC285_RS09875	COG1660	Displays ATPase and GTPase activities
JC285_RS09890	COG0110	maltose O-acetyltransferase activity
JC285_RS09895	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JC285_RS09900	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
JC285_RS09935	COG0653	protein targeting
JC285_RS09950	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
JC285_RS09960	COG1739	Uncharacterized protein family UPF0029
JC285_RS09965	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JC285_RS09985	COG2195	Cleaves the N-terminal amino acid of tripeptides
JC285_RS09995	COG1929	Belongs to the glycerate kinase type-1 family
JC285_RS10000	COG3118	belongs to the thioredoxin family
JC285_RS10015	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JC285_RS10025	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JC285_RS10030	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JC285_RS10065	COG3104	oligopeptide transport
JC285_RS10070	COG3104	oligopeptide transport
JC285_RS10085	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JC285_RS10090	COG1174	glycine betaine transport
JC285_RS10095	COG1125	glycine betaine transport
JC285_RS10095	COG0517	IMP dehydrogenase activity
JC285_RS10100	COG0514	ATP-dependent DNA helicase (RecQ)
JC285_RS10105	COG0488	(ABC) transporter
JC285_RS10115	COG2274	protein secretion by the type I secretion system
JC285_RS10125	COG2274	protein secretion by the type I secretion system
JC285_RS10135	COG0463	Glycosyl transferase, family 2
JC285_RS10140	COG1368	sulfuric ester hydrolase activity
JC285_RS10150	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JC285_RS10170	COG0512	Glutamine amidotransferase of anthranilate synthase
JC285_RS10180	COG0720	synthase
JC285_RS10185	COG0602	queuosine metabolic process
JC285_RS10200	COG0463	Glycosyl transferase, family 2
JC285_RS10205	COG1253	flavin adenine dinucleotide binding
JC285_RS10210	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JC285_RS10210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JC285_RS10210	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JC285_RS10215	COG1105	Belongs to the carbohydrate kinase PfkB family
JC285_RS10220	COG1349	DNA-binding transcription factor activity
JC285_RS10240	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JC285_RS10245	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JC285_RS10265	COG0039	L-malate dehydrogenase activity
JC285_RS10285	COG4989	oxidoreductase activity
JC285_RS10290	COG0523	cobalamin synthesis protein
JC285_RS10300	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
JC285_RS10305	COG4988	ABC transporter
JC285_RS10310	COG1968	undecaprenyl-diphosphatase activity
JC285_RS10320	COG1671	Belongs to the UPF0178 family
JC285_RS10325	COG1611	Belongs to the LOG family
JC285_RS10355	COG2839	Protein conserved in bacteria
JC285_RS10360	COG2814	Major facilitator Superfamily
JC285_RS10365	COG0583	DNA-binding transcription factor activity
JC285_RS10380	COG0217	transcriptional regulatory protein
JC285_RS10385	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JC285_RS10390	COG2022	thiamine diphosphate biosynthetic process
JC285_RS10400	COG0352	thiamine-phosphate diphosphorylase activity
JC285_RS10410	COG3942	CHAP domain
JC285_RS10410	COG1388	LysM domain
JC285_RS10415	COG0306	phosphate transporter
JC285_RS10420	COG1392	Phosphate transport regulator
JC285_RS10430	COG0577	efflux transmembrane transporter activity
JC285_RS10435	COG1136	(ABC) transporter
JC285_RS10445	COG0745	RESPONSE REGULATOR receiver
JC285_RS10450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JC285_RS10455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JC285_RS10465	COG3949	Membrane
JC285_RS10470	COG0477	Major facilitator Superfamily
JC285_RS10480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JC285_RS10485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JC285_RS10490	COG1120	ATPase activity
JC285_RS10495	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JC285_RS10500	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JC285_RS10520	COG1132	(ABC) transporter
JC285_RS10525	COG1686	Belongs to the peptidase S11 family
JC285_RS10535	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
JC285_RS10540	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JC285_RS10545	COG1682	transport, permease protein
JC285_RS10555	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
JC285_RS10570	COG1475	DNA binding
JC285_RS10575	COG0019	diaminopimelate decarboxylase activity
JC285_RS10585	COG4264	IucA IucC family
JC285_RS10590	COG4264	IucA IucC family
JC285_RS10595	COG2814	Major facilitator Superfamily
JC285_RS10600	COG4264	IucA IucC family
JC285_RS10605	COG2423	ornithine cyclodeaminase activity
JC285_RS10615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JC285_RS10620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JC285_RS10625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JC285_RS10635	COG1121	(ABC) transporter
JC285_RS10640	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JC285_RS10645	COG0803	Belongs to the bacterial solute-binding protein 9 family
JC285_RS10650	COG1320	monovalent cation:proton antiporter activity
JC285_RS10655	COG2212	antiporter activity
JC285_RS10660	COG1863	multisubunit Na H antiporter MnhE subunit
JC285_RS10670	COG1006	Multisubunit Na H antiporter MnhC subunit
JC285_RS10675	COG2111	Na H antiporter
JC285_RS10680	COG2111	Na H antiporter
JC285_RS10680	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JC285_RS10735	COG0546	phosphoglycolate phosphatase activity
JC285_RS10740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JC285_RS10745	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JC285_RS10750	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JC285_RS10755	COG0805	protein transport
JC285_RS10760	COG0018	arginyl-trna synthetase
JC285_RS10775	COG1078	dGTPase activity
JC285_RS10785	COG4844	belongs to the
JC285_RS10850	COG0471	metal ion transport
JC285_RS10875	COG0280	phosphate acetyltransferase
JC285_RS10880	COG0095	Lipoate-protein ligase
JC285_RS10900	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JC285_RS10905	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
JC285_RS10915	COG2814	Major facilitator Superfamily
JC285_RS10920	COG1566	PFAM secretion protein HlyD family protein
JC285_RS10965	COG2363	Small membrane protein
JC285_RS10995	COG0183	Belongs to the thiolase family
JC285_RS11000	COG0318	PFAM AMP-dependent synthetase and ligase
JC285_RS11005	COG0588	phosphoglycerate mutase activity
JC285_RS11030	COG1131	(ABC) transporter
JC285_RS11035	COG1994	Peptidase M50
JC285_RS11040	COG0535	radical SAM domain protein
JC285_RS11050	COG2801	Transposase and inactivated derivatives
JC285_RS11060	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JC285_RS11065	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JC285_RS11075	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
JC285_RS11090	COG1263	PTS System
JC285_RS11090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JC285_RS11090	COG2190	(PTS) system
JC285_RS11105	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JC285_RS11110	COG1469	GTP cyclohydrolase I activity
JC285_RS11135	COG0561	phosphatase activity
JC285_RS11145	COG1428	Deoxynucleoside kinase
JC285_RS11150	COG1428	Deoxynucleoside kinase
JC285_RS11155	COG0546	phosphoglycolate phosphatase activity
JC285_RS11170	COG0488	(ABC) transporter
JC285_RS11175	COG1121	(ABC) transporter
JC285_RS11190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JC285_RS11200	COG1473	amidohydrolase
JC285_RS11205	COG3527	Alpha-acetolactate decarboxylase
JC285_RS11210	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JC285_RS11215	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JC285_RS11220	COG0049	tRNA binding
JC285_RS11225	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JC285_RS11235	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JC285_RS11240	COG0085	RNA polymerase activity
JC285_RS11245	COG2813	Specifically methylates the guanine in position
JC285_RS11255	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JC285_RS11260	COG0081	regulation of translation
JC285_RS11265	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JC285_RS11270	COG0250	Participates in transcription elongation, termination and antitermination
JC285_RS11275	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JC285_RS11280	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JC285_RS11300	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
JC285_RS11305	COG0215	cysteine-tRNA ligase activity
JC285_RS11310	COG1045	serine acetyltransferase
JC285_RS11315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JC285_RS11325	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JC285_RS11330	COG4956	integral membrane protein (PIN domain superfamily)
JC285_RS11335	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JC285_RS11370	COG0542	response to heat
JC285_RS11375	COG3869	Catalyzes the specific phosphorylation of arginine residues in
JC285_RS11380	COG3880	PFAM UvrB UvrC protein
JC285_RS11390	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JC285_RS11400	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
JC285_RS11405	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
JC285_RS11410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JC285_RS11415	COG1289	transmembrane transporter activity
JC285_RS11505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JC285_RS11510	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JC285_RS11530	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
JC285_RS11535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JC285_RS11550	COG1098	S1 RNA binding domain
JC285_RS11560	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
JC285_RS11565	COG3956	TIGRFAM MazG family protein
JC285_RS11570	COG2244	polysaccharide biosynthetic process
JC285_RS11575	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JC285_RS11580	COG0193	aminoacyl-tRNA hydrolase activity
JC285_RS11590	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JC285_RS11595	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JC285_RS11600	COG2088	sporulation resulting in formation of a cellular spore
JC285_RS11605	COG0251	oxidation-reduction process
JC285_RS11610	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JC285_RS11615	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JC285_RS11620	COG4466	Protein conserved in bacteria
JC285_RS11625	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JC285_RS11630	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
JC285_RS11635	COG0084	hydrolase, TatD family'
JC285_RS11645	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
JC285_RS11650	COG2827	Endonuclease containing a URI domain
JC285_RS11655	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
JC285_RS11660	COG4467	Involved in initiation control of chromosome replication
JC285_RS11665	COG1774	PSP1 C-terminal conserved region
JC285_RS11670	COG0470	DNA polymerase III
JC285_RS11675	COG3870	Protein conserved in bacteria
JC285_RS11680	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JC285_RS11685	COG1982	Orn Lys Arg decarboxylase major
JC285_RS11710	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JC285_RS11715	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JC285_RS11720	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JC285_RS11725	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JC285_RS11735	COG2188	Transcriptional regulator
JC285_RS11740	COG0366	Alpha amylase catalytic
JC285_RS11745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JC285_RS11745	COG1263	PTS System
JC285_RS11755	COG0493	'glutamate synthase
JC285_RS11760	COG0069	glutamate synthase activity
JC285_RS11760	COG0070	glutamate synthase
JC285_RS11760	COG0067	glutamate synthase
JC285_RS11765	COG0583	DNA-binding transcription factor activity
JC285_RS11780	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JC285_RS11805	COG0626	cystathionine gamma-synthase activity
JC285_RS11810	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JC285_RS11815	COG2272	Belongs to the type-B carboxylesterase lipase family
JC285_RS11820	COG0733	neurotransmitter:sodium symporter activity
JC285_RS11830	COG0745	RESPONSE REGULATOR receiver
JC285_RS11835	COG2205	protein histidine kinase activity
JC285_RS11845	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
JC285_RS11850	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
JC285_RS11865	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JC285_RS11870	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JC285_RS11870	COG0574	Belongs to the PEP-utilizing enzyme family
JC285_RS11890	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
JC285_RS11900	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
JC285_RS11910	COG1486	melibiose metabolic process
JC285_RS11915	COG1263	PTS System
JC285_RS11915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JC285_RS11935	COG2210	Belongs to the sulfur carrier protein TusA family
JC285_RS11940	COG1937	Protein conserved in bacteria
JC285_RS11945	COG0730	response to heat
JC285_RS11950	COG2814	Major facilitator Superfamily
JC285_RS11965	COG1124	(ABC) transporter
JC285_RS11970	COG0444	Belongs to the ABC transporter superfamily
JC285_RS11975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JC285_RS11980	COG0601	transmembrane transport
JC285_RS11985	COG0747	negative chemotaxis
JC285_RS12010	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
JC285_RS12030	COG1525	nuclease
JC285_RS12060	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JC285_RS12060	COG0519	Catalyzes the synthesis of GMP from XMP
JC285_RS12065	COG0516	GMP reductase activity
JC285_RS12065	COG0517	IMP dehydrogenase activity
JC285_RS12070	COG2233	PERMEase
JC285_RS12075	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JC285_RS12090	COG5183	chlorophyll binding
JC285_RS12095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JC285_RS12100	COG1823	symporter activity
JC285_RS12105	COG0577	efflux transmembrane transporter activity
JC285_RS12105	COG1136	(ABC) transporter
JC285_RS12120	COG0778	Nitroreductase
JC285_RS12125	COG0450	alkyl hydroperoxide reductase
JC285_RS12140	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JC285_RS12150	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JC285_RS12155	COG2011	ABC-type metal ion transport system permease component
JC285_RS12160	COG1464	Belongs to the NlpA lipoprotein family
JC285_RS12165	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JC285_RS12170	COG0753	catalase activity
JC285_RS12175	COG3842	ATPase activity
JC285_RS12180	COG0673	inositol 2-dehydrogenase activity
JC285_RS12185	COG0395	ABC-type sugar transport system, permease component
JC285_RS12190	COG1175	transmembrane transport
JC285_RS12200	COG2207	Transcriptional regulator
JC285_RS12200	COG0662	Cupin 2, conserved barrel domain protein
JC285_RS12205	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JC285_RS12215	COG0360	Binds together with S18 to 16S ribosomal RNA
JC285_RS12225	COG1668	transmembrane transport
JC285_RS12230	COG1131	(ABC) transporter
JC285_RS12245	COG0012	GTP binding
JC285_RS12250	COG4481	Protein conserved in bacteria
JC285_RS12255	COG0668	transmembrane transport
JC285_RS12260	COG1475	DNA binding
JC285_RS12265	COG0626	cystathionine gamma-synthase activity
JC285_RS12270	COG0626	cystathionine gamma-synthase activity
JC285_RS12275	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
JC285_RS12275	COG0646	methionine synthase
JC285_RS12285	COG0829	nickel cation binding
JC285_RS12295	COG0830	nickel cation binding
JC285_RS12300	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
JC285_RS12310	COG2388	GCN5-related N-acetyl-transferase
JC285_RS12315	COG1846	Transcriptional regulator
JC285_RS12320	COG0346	lactoylglutathione lyase activity
JC285_RS12325	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JC285_RS12330	COG0400	carboxylic ester hydrolase activity
JC285_RS12355	COG0357	Ribosomal RNA small subunit methyltransferase G
JC285_RS12360	COG0445	tRNA wobble uridine modification
JC285_RS12365	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
JC285_RS12370	COG0594	ribonuclease P activity