locus-tag	class	description
JC286_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JC286_RS00010	COG0592	DNA-directed DNA polymerase activity
JC286_RS00015	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JC286_RS00015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JC286_RS00020	COG2501	S4 domain
JC286_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JC286_RS00030	COG0187	DNA topoisomerase II activity
JC286_RS00040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JC286_RS00045	COG2986	histidine ammonia-lyase
JC286_RS00055	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
JC286_RS00065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JC286_RS00070	COG4241	membrane
JC286_RS00075	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
JC286_RS00080	COG0359	binds to the 23S rRNA
JC286_RS00085	COG0305	Participates in initiation and elongation during chromosome replication
JC286_RS00090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JC286_RS00095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JC286_RS00115	COG0745	RESPONSE REGULATOR receiver
JC286_RS00120	COG5002	protein histidine kinase activity
JC286_RS00125	COG4863	YycH protein
JC286_RS00135	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
JC286_RS00210	COG0531	amino acid
JC286_RS00215	COG2217	Heavy metal translocating P-type atpase
JC286_RS00225	COG2188	Transcriptional regulator
JC286_RS00230	COG2723	6-phospho-beta-galactosidase activity
JC286_RS00240	COG0415	Belongs to the DNA photolyase family
JC286_RS00255	COG0702	epimerase
JC286_RS00260	COG2130	NADP-dependent
JC286_RS00275	COG3177	Filamentation induced by cAMP protein fic
JC286_RS00280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JC286_RS00285	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JC286_RS00285	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JC286_RS00290	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
JC286_RS00295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JC286_RS00315	COG2235	arginine
JC286_RS00330	COG2197	response regulator
JC286_RS00335	COG4585	Histidine kinase
JC286_RS00335	COG2203	Gaf domain
JC286_RS00340	COG0842	Transport permease protein
JC286_RS00345	COG1131	(ABC) transporter
JC286_RS00365	COG0431	NADPH-dependent FMN reductase
JC286_RS00370	COG4932	domain protein
JC286_RS00370	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JC286_RS00370	COG3583	domain protein
JC286_RS00390	COG1609	Transcriptional regulator
JC286_RS00400	COG0673	inositol 2-dehydrogenase activity
JC286_RS00410	COG0366	Alpha amylase catalytic
JC286_RS00420	COG3833	ABC-type maltose transport systems, permease component
JC286_RS00425	COG1175	transmembrane transport
JC286_RS00435	COG3842	ATPase activity
JC286_RS00440	COG0475	glutathione-regulated potassium exporter activity
JC286_RS00445	COG0490	domain, Protein
JC286_RS00455	COG0346	lactoylglutathione lyase activity
JC286_RS00490	COG1131	(ABC) transporter
JC286_RS00500	COG0366	Alpha amylase catalytic
JC286_RS00505	COG2188	Transcriptional regulator
JC286_RS00510	COG2222	sugar isomerase
JC286_RS00515	COG1105	Belongs to the carbohydrate kinase PfkB family
JC286_RS00530	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
JC286_RS00530	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JC286_RS00535	COG3715	PTS system
JC286_RS00540	COG3716	PTS system mannose fructose sorbose family IID component
JC286_RS00550	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JC286_RS00570	COG3314	Sporulation integral membrane protein YlbJ
JC286_RS00590	COG1063	alcohol dehydrogenase
JC286_RS00605	COG1620	l-lactate permease
JC286_RS00610	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
JC286_RS00615	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JC286_RS00620	COG0156	8-amino-7-oxononanoate synthase activity
JC286_RS00665	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
JC286_RS00680	COG0076	glutamate decarboxylase activity
JC286_RS00695	COG2318	DinB family
JC286_RS00700	COG0753	catalase activity
JC286_RS00710	COG0783	Belongs to the Dps family
JC286_RS00720	COG0436	Aminotransferase
JC286_RS00740	COG3344	reverse transcriptase
JC286_RS00750	COG1136	(ABC) transporter
JC286_RS00760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JC286_RS00775	COG1755	Isoprenylcysteine carboxyl methyltransferase
JC286_RS00800	COG0579	oxidoreductase
JC286_RS00840	COG1073	alpha beta
JC286_RS00860	COG0438	transferase activity, transferring glycosyl groups
JC286_RS00865	COG0183	Belongs to the thiolase family
JC286_RS00880	COG0318	PFAM AMP-dependent synthetase and ligase
JC286_RS00890	COG2814	Major facilitator Superfamily
JC286_RS00900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JC286_RS00930	COG1609	Transcriptional regulator
JC286_RS00935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JC286_RS00960	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JC286_RS00990	COG3711	transcriptional antiterminator
JC286_RS00995	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JC286_RS01005	COG3037	sugar-specific permease SgaT UlaA
JC286_RS01015	COG1328	CTP reductase activity
JC286_RS01035	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JC286_RS01040	COG1942	4-Oxalocrotonate Tautomerase
JC286_RS01050	COG3443	Belongs to the bacterial solute-binding protein 9 family
JC286_RS01050	COG0803	Belongs to the bacterial solute-binding protein 9 family
JC286_RS01075	COG4753	response regulator
JC286_RS01075	COG2207	Transcriptional regulator
JC286_RS01080	COG2972	Histidine kinase
JC286_RS01095	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JC286_RS01100	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JC286_RS01105	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
JC286_RS01110	COG0477	Major facilitator Superfamily
JC286_RS01115	COG2211	Major facilitator Superfamily
JC286_RS01120	COG3250	beta-galactosidase activity
JC286_RS01125	COG1957	nucleoside hydrolase
JC286_RS01140	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
JC286_RS01145	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
JC286_RS01150	COG2807	transmembrane transport
JC286_RS01155	COG1396	sequence-specific DNA binding
JC286_RS01170	COG1785	Belongs to the alkaline phosphatase family
JC286_RS01175	COG0494	nUDIX hydrolase
JC286_RS01180	COG0556	nucleotide-excision repair
JC286_RS01195	COG1510	regulation of RNA biosynthetic process
JC286_RS01200	COG1012	belongs to the aldehyde dehydrogenase family
JC286_RS01205	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
JC286_RS01210	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JC286_RS01220	COG0107	imidazoleglycerol-phosphate synthase activity
JC286_RS01225	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JC286_RS01240	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JC286_RS01245	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JC286_RS01250	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JC286_RS01255	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
JC286_RS01290	COG2376	Dihydroxyacetone kinase
JC286_RS01295	COG1461	Dihydroxyacetone kinase
JC286_RS01300	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
JC286_RS01305	COG2824	Alkylphosphonate utilization operon protein PhnA
JC286_RS01310	COG1012	belongs to the aldehyde dehydrogenase family
JC286_RS01320	COG0596	Alpha beta hydrolase
JC286_RS01325	COG0789	Transcriptional regulator
JC286_RS01330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JC286_RS01330	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JC286_RS01330	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JC286_RS01340	COG3942	CHAP domain
JC286_RS01340	COG1705	Flagellar rod assembly protein muramidase FlgJ
JC286_RS01350	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JC286_RS01355	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JC286_RS01360	COG0747	negative chemotaxis
JC286_RS01385	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JC286_RS01385	COG0463	Glycosyl transferase, family 2
JC286_RS01390	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JC286_RS01390	COG0463	Glycosyl transferase, family 2
JC286_RS01395	COG0438	transferase activity, transferring glycosyl groups
JC286_RS01400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JC286_RS01405	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JC286_RS01420	COG3181	Tripartite tricarboxylate transporter family receptor
JC286_RS01425	COG0778	Nitroreductase
JC286_RS01430	COG3001	Fructosamine kinase
JC286_RS01455	COG1136	(ABC) transporter
JC286_RS01460	COG0577	efflux transmembrane transporter activity
JC286_RS01480	COG4413	Urea transporter
JC286_RS01490	COG0832	Belongs to the urease beta subunit family
JC286_RS01495	COG0804	urea catabolic process
JC286_RS01500	COG0717	Belongs to the dCTP deaminase family
JC286_RS01505	COG0523	cobalamin synthesis protein
JC286_RS01515	COG1141	Ferredoxin
JC286_RS01540	COG0583	DNA-binding transcription factor activity
JC286_RS01550	COG1346	cytolysis
JC286_RS01565	COG1846	Transcriptional regulator
JC286_RS01570	COG0778	Nitroreductase
JC286_RS01575	COG2357	RelA SpoT domain protein
JC286_RS01615	COG1028	Short-chain dehydrogenase reductase Sdr
JC286_RS01630	COG3835	regulator
JC286_RS01635	COG2855	membrane
JC286_RS01640	COG3961	Belongs to the TPP enzyme family
JC286_RS01645	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JC286_RS01650	COG0512	Glutamine amidotransferase of anthranilate synthase
JC286_RS01660	COG0134	indole-3-glycerol-phosphate synthase activity
JC286_RS01670	COG0133	tryptophan synthase activity
JC286_RS01675	COG0159	tryptophan synthase activity
JC286_RS01695	COG0277	FAD linked oxidase domain protein
JC286_RS01700	COG0247	lactate metabolic process
JC286_RS01705	COG1132	(ABC) transporter
JC286_RS01710	COG1132	(ABC) transporter
JC286_RS01715	COG0789	Transcriptional regulator
JC286_RS01720	COG3871	stress protein (general stress protein 26)
JC286_RS01725	COG1115	amino acid carrier protein
JC286_RS01730	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
JC286_RS01735	COG2814	Major facilitator Superfamily
JC286_RS01740	COG2271	Major facilitator Superfamily
JC286_RS01745	COG3764	Sortase (surface protein transpeptidase)
JC286_RS01750	COG1929	Belongs to the glycerate kinase type-1 family
JC286_RS01760	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
JC286_RS01780	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JC286_RS01785	COG0702	epimerase
JC286_RS01795	COG4166	transmembrane transport
JC286_RS01800	COG0444	Belongs to the ABC transporter superfamily
JC286_RS01805	COG4608	Belongs to the ABC transporter superfamily
JC286_RS01815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JC286_RS01820	COG4166	transmembrane transport
JC286_RS01825	COG0444	Belongs to the ABC transporter superfamily
JC286_RS01830	COG4608	Belongs to the ABC transporter superfamily
JC286_RS01835	COG0601	transmembrane transport
JC286_RS01840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JC286_RS01850	COG1760	l-serine dehydratase
JC286_RS01855	COG1760	l-serine dehydratase
JC286_RS01905	COG0471	metal ion transport
JC286_RS01910	COG2116	formate transmembrane transporter activity
JC286_RS01915	COG0454	-acetyltransferase
JC286_RS01925	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JC286_RS01925	COG1648	precorrin-2 dehydrogenase activity
JC286_RS01930	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JC286_RS01935	COG2146	nitrite reductase [NAD(P)H] activity
JC286_RS01940	COG1648	precorrin-2 dehydrogenase activity
JC286_RS01940	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JC286_RS01945	COG0737	Belongs to the 5'-nucleotidase family
JC286_RS01955	COG0018	arginyl-trna synthetase
JC286_RS01975	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
JC286_RS01980	COG1140	nitrate reductase beta subunit
JC286_RS01990	COG2181	nitrate reductase activity
JC286_RS02000	COG4585	Histidine kinase
JC286_RS02005	COG2197	response regulator
JC286_RS02010	COG2223	nitrite transmembrane transporter activity
JC286_RS02015	COG4187	Peptidase family M20/M25/M40
JC286_RS02025	COG0039	L-malate dehydrogenase activity
JC286_RS02030	COG1363	Peptidase, m42
JC286_RS02035	COG0697	spore germination
JC286_RS02045	COG2807	transmembrane transport
JC286_RS02055	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JC286_RS02055	COG1263	PTS System
JC286_RS02070	COG1283	sodium-dependent phosphate transmembrane transporter activity
JC286_RS02090	COG0492	ferredoxin-NADP+ reductase activity
JC286_RS02095	COG2814	Major facilitator Superfamily
JC286_RS02100	COG0604	alcohol dehydrogenase
JC286_RS02115	COG1620	l-lactate permease
JC286_RS02120	COG0438	transferase activity, transferring glycosyl groups
JC286_RS02125	COG0579	oxidoreductase
JC286_RS02140	COG0577	efflux transmembrane transporter activity
JC286_RS02175	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
JC286_RS02185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JC286_RS02205	COG1304	FMN binding
JC286_RS02210	COG0523	cobalamin synthesis protein
JC286_RS02215	COG0786	glutamate:sodium symporter activity
JC286_RS02220	COG2207	Transcriptional regulator
JC286_RS02225	COG3250	beta-galactosidase activity
JC286_RS02245	COG1757	Na H antiporter
JC286_RS02250	COG2094	Belongs to the DNA glycosylase MPG family
JC286_RS02255	COG3152	Membrane
JC286_RS02260	COG4152	abc transporter atp-binding protein
JC286_RS02265	COG1668	transmembrane transport
JC286_RS02270	COG1742	UPF0060 membrane protein
JC286_RS02275	COG2017	converts alpha-aldose to the beta-anomer
JC286_RS02280	COG2258	MOSC domain
JC286_RS02285	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
JC286_RS02295	COG1266	CAAX protease self-immunity
JC286_RS02300	COG0583	DNA-binding transcription factor activity
JC286_RS02305	COG3314	Sporulation integral membrane protein YlbJ
JC286_RS02310	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
JC286_RS02315	COG1228	amidohydrolase
JC286_RS02320	COG0659	secondary active sulfate transmembrane transporter activity
JC286_RS02325	COG1473	amidohydrolase
JC286_RS02345	COG0385	Bile acid
JC286_RS02355	COG0346	lactoylglutathione lyase activity
JC286_RS02360	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JC286_RS02385	COG1113	amino acid transport
JC286_RS02410	COG1316	TRANSCRIPTIONal
JC286_RS02425	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
JC286_RS02430	COG3383	formate dehydrogenase (NAD+) activity
JC286_RS02455	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JC286_RS02460	COG2076	Multidrug Resistance protein
JC286_RS02465	COG2076	Multidrug Resistance protein
JC286_RS02470	COG3942	CHAP domain
JC286_RS02480	COG1757	Na H antiporter
JC286_RS02490	COG3942	CHAP domain
JC286_RS02510	COG1960	acyl-CoA dehydrogenase activity
JC286_RS02515	COG2832	Protein of unknown function (DUF454)
JC286_RS02520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JC286_RS02525	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JC286_RS02535	COG2186	Transcriptional regulator
JC286_RS02545	COG1268	BioY protein
JC286_RS02560	COG1609	Transcriptional regulator
JC286_RS02565	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JC286_RS02570	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JC286_RS02575	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
JC286_RS02585	COG4149	molybdate abc transporter
JC286_RS02590	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
JC286_RS02595	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JC286_RS02600	COG0521	Mo-molybdopterin cofactor biosynthetic process
JC286_RS02620	COG0314	molybdopterin synthase activity
JC286_RS02630	COG0746	molybdenum cofactor guanylyltransferase activity
JC286_RS02635	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JC286_RS02660	COG2348	transferase activity, transferring amino-acyl groups
JC286_RS02665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JC286_RS02670	COG0436	Aminotransferase
JC286_RS02695	COG0551	DNA topoisomerase type I activity
JC286_RS02695	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JC286_RS02700	COG2252	PERMEase
JC286_RS02720	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JC286_RS02725	COG0088	Forms part of the polypeptide exit tunnel
JC286_RS02730	COG0089	rRNA binding
JC286_RS02735	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JC286_RS02740	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JC286_RS02745	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JC286_RS02750	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JC286_RS02755	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JC286_RS02760	COG0255	Belongs to the universal ribosomal protein uL29 family
JC286_RS02770	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JC286_RS02785	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JC286_RS02790	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JC286_RS02795	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JC286_RS02805	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JC286_RS02810	COG1841	ribosomal large subunit assembly
JC286_RS02820	COG0201	protein transport
JC286_RS02835	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JC286_RS02845	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JC286_RS02850	COG0202	RNA polymerase activity
JC286_RS02855	COG0203	ribosomal protein L17
JC286_RS02860	COG1122	ATPase activity
JC286_RS02865	COG1122	ATPase activity
JC286_RS02875	COG0101	tRNA pseudouridine synthase activity
JC286_RS02880	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JC286_RS02900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JC286_RS02965	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
JC286_RS02975	COG1335	isochorismatase
JC286_RS02995	COG3684	Belongs to the aldolase LacD family
JC286_RS03005	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JC286_RS03005	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JC286_RS03020	COG1518	maintenance of DNA repeat elements
JC286_RS03040	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JC286_RS03055	COG1302	Protein conserved in bacteria
JC286_RS03060	COG2814	Major facilitator Superfamily
JC286_RS03065	COG4264	IucA IucC family
JC286_RS03070	COG2814	Major facilitator Superfamily
JC286_RS03075	COG4264	IucA IucC family
JC286_RS03080	COG3457	Alanine racemase
JC286_RS03085	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
JC286_RS03090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JC286_RS03095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JC286_RS03100	COG3314	Sporulation integral membrane protein YlbJ
JC286_RS03110	COG1988	membrane-bound metal-dependent
JC286_RS03115	COG4284	Utp--glucose-1-phosphate uridylyltransferase
JC286_RS03120	COG1272	protein, Hemolysin III
JC286_RS03140	COG2814	Major facilitator Superfamily
JC286_RS03145	COG0489	protein tyrosine kinase activity
JC286_RS03210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JC286_RS03230	COG3711	transcriptional antiterminator
JC286_RS03260	COG1119	ATPase activity
JC286_RS03265	COG0561	phosphatase activity
JC286_RS03275	COG2186	Transcriptional regulator
JC286_RS03280	COG1482	cell wall glycoprotein biosynthetic process
JC286_RS03295	COG1757	Na H antiporter
JC286_RS03305	COG0813	purine-nucleoside phosphorylase activity
JC286_RS03340	COG5146	pantothenate kinase activity
JC286_RS03350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JC286_RS03360	COG0504	CTP synthase activity
JC286_RS03365	COG2271	Major facilitator Superfamily
JC286_RS03370	COG4821	SIS domain
JC286_RS03375	COG0191	fructose-bisphosphate aldolase activity
JC286_RS03380	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JC286_RS03385	COG1733	regulation of RNA biosynthetic process
JC286_RS03395	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
JC286_RS03400	COG0254	rRNA binding
JC286_RS03410	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JC286_RS03415	COG2890	protein-(glutamine-N5) methyltransferase activity
JC286_RS03420	COG0009	L-threonylcarbamoyladenylate synthase
JC286_RS03425	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JC286_RS03430	COG4475	Protein of unknown function (DUF436)
JC286_RS03435	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JC286_RS03440	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JC286_RS03445	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
JC286_RS03455	COG0356	it plays a direct role in the translocation of protons across the membrane
JC286_RS03460	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JC286_RS03470	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JC286_RS03480	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JC286_RS03510	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JC286_RS03525	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
JC286_RS03535	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
JC286_RS03540	COG0352	thiamine-phosphate diphosphorylase activity
JC286_RS03545	COG0706	membrane insertase activity
JC286_RS03550	COG1418	mRNA catabolic process
JC286_RS03555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JC286_RS03560	COG1937	Protein conserved in bacteria
JC286_RS03575	COG2217	Heavy metal translocating P-type atpase
JC286_RS03590	COG0772	Belongs to the SEDS family
JC286_RS03595	COG1181	Belongs to the D-alanine--D-alanine ligase family
JC286_RS03600	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JC286_RS03605	COG0513	Belongs to the DEAD box helicase family
JC286_RS03620	COG3402	PFAM membrane-flanked domain
JC286_RS03625	COG0736	holo-[acyl-carrier-protein] synthase activity
JC286_RS03630	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JC286_RS03640	COG2337	Toxic component of a toxin-antitoxin (TA) module
JC286_RS03645	COG2208	phosphoserine phosphatase activity
JC286_RS03650	COG1366	Belongs to the anti-sigma-factor antagonist family
JC286_RS03660	COG1191	sigma factor activity
JC286_RS03665	COG2183	response to ionizing radiation
JC286_RS03670	COG3091	SprT-like family
JC286_RS03715	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JC286_RS03725	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JC286_RS03730	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JC286_RS03740	COG0028	Belongs to the TPP enzyme family
JC286_RS03745	COG0129	dihydroxy-acid dehydratase activity
JC286_RS03750	COG0802	atpase or kinase
JC286_RS03755	COG1214	PFAM Peptidase M22, glycoprotease
JC286_RS03760	COG0456	acetyltransferase
JC286_RS03765	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JC286_RS03775	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JC286_RS03780	COG0488	(ABC) transporter
JC286_RS03785	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
JC286_RS03790	COG2814	Major facilitator Superfamily
JC286_RS03795	COG1846	Transcriptional regulator
JC286_RS03805	COG2124	cytochrome p450
JC286_RS03810	COG1609	Transcriptional regulator
JC286_RS03815	COG1621	beta-fructofuranosidase activity
JC286_RS03820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JC286_RS03840	COG4512	PFAM Accessory gene regulator B
JC286_RS03890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JC286_RS03895	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JC286_RS03915	COG1131	(ABC) transporter
JC286_RS03930	COG1070	Carbohydrate kinase
JC286_RS03935	COG2610	gluconate transmembrane transporter activity
JC286_RS03970	COG2706	6-phosphogluconolactonase activity
JC286_RS03975	COG1012	belongs to the aldehyde dehydrogenase family
JC286_RS03985	COG1227	inorganic diphosphatase activity
JC286_RS03990	COG1335	isochorismatase
JC286_RS04000	COG0077	Prephenate dehydratase
JC286_RS04010	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
JC286_RS04020	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
JC286_RS04030	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JC286_RS04035	COG4496	protein, YerC YecD
JC286_RS04040	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
JC286_RS04045	COG0210	DNA helicase
JC286_RS04050	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JC286_RS04055	COG4851	CamS sex pheromone cAM373 precursor
JC286_RS04060	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JC286_RS04065	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JC286_RS04075	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JC286_RS04080	COG1597	lipid kinase activity
JC286_RS04105	COG0488	(ABC) transporter
JC286_RS04115	COG1396	sequence-specific DNA binding
JC286_RS04125	COG2211	Major facilitator Superfamily
JC286_RS04135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JC286_RS04145	COG1528	Iron-storage protein
JC286_RS04160	COG4129	membrane
JC286_RS04165	COG0024	Methionine aminopeptidase
JC286_RS04190	COG0288	reversible hydration of carbon dioxide
JC286_RS04195	COG1295	ribonuclease BN
JC286_RS04210	COG4840	Belongs to the UPF0435 family
JC286_RS04215	COG2309	aminopeptidase activity
JC286_RS04220	COG1607	acyl-coa hydrolase
JC286_RS04225	COG0535	radical SAM domain protein
JC286_RS04235	COG0693	protein deglycase activity
JC286_RS04240	COG0028	Belongs to the TPP enzyme family
JC286_RS04245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JC286_RS04250	COG2137	regulation of response to DNA damage stimulus
JC286_RS04260	COG1134	teichoic acid transport
JC286_RS04260	COG1388	LysM domain
JC286_RS04270	COG1988	membrane-bound metal-dependent
JC286_RS04275	COG1194	a g-specific adenine glycosylase
JC286_RS04280	COG3557	Belongs to the UPF0374 family
JC286_RS04290	COG0069	glutamate synthase activity
JC286_RS04295	COG4129	membrane
JC286_RS04300	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JC286_RS04305	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JC286_RS04315	COG0735	belongs to the Fur family
JC286_RS04540	COG0765	amino acid transport
JC286_RS04545	COG1126	abc transporter atp-binding protein
JC286_RS04550	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JC286_RS04560	COG0363	glucosamine-6-phosphate deaminase activity
JC286_RS04575	COG0114	fumarate hydratase activity
JC286_RS04580	COG0248	Ppx GppA phosphatase
JC286_RS04585	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
JC286_RS04590	COG0564	pseudouridine synthase activity
JC286_RS04595	COG2203	Gaf domain
JC286_RS04595	COG4585	Histidine kinase
JC286_RS04600	COG2197	response regulator
JC286_RS04605	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
JC286_RS04620	COG4399	Belongs to the UPF0754 family
JC286_RS04625	COG3679	Belongs to the UPF0342 family
JC286_RS04630	COG0420	3'-5' exonuclease activity
JC286_RS04640	COG3481	metal-dependent phosphohydrolase, HD sub domain
JC286_RS04645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JC286_RS04660	COG1846	Transcriptional regulator
JC286_RS04670	COG0537	adenosine 5'-monophosphoramidase activity
JC286_RS04675	COG1131	(ABC) transporter
JC286_RS04680	COG4473	ABC transporter
JC286_RS04690	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JC286_RS04700	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
JC286_RS04705	COG3545	Serine hydrolase
JC286_RS04755	COG0582	viral genome integration into host DNA
JC286_RS05015	COG4824	toxin secretion phage lysis holin
JC286_RS05075	COG3037	sugar-specific permease SgaT UlaA
JC286_RS05095	COG3623	hexulose-6-phosphate isomerase
JC286_RS05100	COG0235	Class ii aldolase
JC286_RS05120	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
JC286_RS05125	COG0494	nUDIX hydrolase
JC286_RS05130	COG1506	peptidase
JC286_RS05135	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
JC286_RS05140	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JC286_RS05150	COG0656	L-ascorbic acid biosynthetic process
JC286_RS05155	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JC286_RS05160	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JC286_RS05170	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JC286_RS05195	COG3266	domain, Protein
JC286_RS05195	COG4193	domain, Protein
JC286_RS05195	COG5632	N-Acetylmuramoyl-L-alanine amidase
JC286_RS05205	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JC286_RS05205	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JC286_RS05210	COG0307	riboflavin synthase, alpha
JC286_RS05215	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JC286_RS05215	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JC286_RS05220	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
JC286_RS05235	COG2267	carboxylic ester hydrolase activity
JC286_RS05240	COG0039	L-malate dehydrogenase activity
JC286_RS05250	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
JC286_RS05255	COG1242	4 iron, 4 sulfur cluster binding
JC286_RS05260	COG2814	Major facilitator Superfamily
JC286_RS05265	COG0495	leucyl-tRNA aminoacylation
JC286_RS05270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JC286_RS05275	COG2081	HI0933 family
JC286_RS05280	COG2244	polysaccharide biosynthetic process
JC286_RS05285	COG1187	pseudouridine synthase activity
JC286_RS05295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JC286_RS05300	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JC286_RS05305	COG0510	thiamine kinase activity
JC286_RS05310	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JC286_RS05315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JC286_RS05325	COG1363	Peptidase, m42
JC286_RS05330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JC286_RS05335	COG4848	Belongs to the UPF0354 family
JC286_RS05340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JC286_RS05345	COG1674	ftsk spoiiie
JC286_RS05350	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JC286_RS05355	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
JC286_RS05365	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
JC286_RS05365	COG1605	Chorismate mutase
JC286_RS05370	COG1609	Transcriptional regulator
JC286_RS05380	COG0454	-acetyltransferase
JC286_RS05385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JC286_RS05390	COG2759	Belongs to the formate--tetrahydrofolate ligase family
JC286_RS05395	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
JC286_RS05405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JC286_RS05410	COG0204	Acyl-transferase
JC286_RS05420	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JC286_RS05425	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JC286_RS05430	COG1764	response to oxidative stress
JC286_RS05480	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JC286_RS05485	COG1956	GAF domain-containing protein
JC286_RS05490	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
JC286_RS05495	COG1104	cysteine desulfurase activity
JC286_RS05500	COG0301	tRNA thio-modification
JC286_RS05510	COG0616	signal peptide processing
JC286_RS05515	COG1714	RDD family
JC286_RS05520	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
JC286_RS05525	COG0827	DNA restriction-modification system
JC286_RS05530	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JC286_RS05535	COG0589	response to stress
JC286_RS05540	COG0686	Belongs to the AlaDH PNT family
JC286_RS05550	COG0006	proline dipeptidase activity
JC286_RS05555	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
JC286_RS05565	COG4109	DRTGG domain
JC286_RS05570	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
JC286_RS05575	COG0587	DNA-directed DNA polymerase activity
JC286_RS05580	COG0281	malic enzyme
JC286_RS05585	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JC286_RS05590	COG0825	malonyl-CoA metabolic process
JC286_RS05595	COG0205	6-phosphofructokinase activity
JC286_RS05600	COG0469	pyruvate kinase activity
JC286_RS05605	COG0372	Belongs to the citrate synthase family
JC286_RS05610	COG0538	isocitrate dehydrogenase activity
JC286_RS05615	COG0745	RESPONSE REGULATOR receiver
JC286_RS05620	COG5002	protein histidine kinase activity
JC286_RS05625	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JC286_RS05625	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JC286_RS05635	COG0237	dephospho-CoA kinase activity
JC286_RS05650	COG3611	Membrane attachment protein
JC286_RS05655	COG1484	DNA-dependent DNA replication
JC286_RS05665	COG0833	amino acid
JC286_RS05675	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JC286_RS05680	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JC286_RS05685	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
JC286_RS05700	COG0544	peptidyl-prolyl cis-trans isomerase activity
JC286_RS05710	COG0218	Necessary for normal cell division and for the maintenance of normal septation
JC286_RS05715	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JC286_RS05725	COG0181	hydroxymethylbilane synthase activity
JC286_RS05740	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JC286_RS05750	COG2818	Glycosylase
JC286_RS05755	COG0525	valine-tRNA ligase activity
JC286_RS05760	COG0285	dihydrofolate synthase activity
JC286_RS05770	COG2003	Belongs to the UPF0758 family
JC286_RS05805	COG2868	ribosomal protein
JC286_RS05815	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JC286_RS05825	COG0632	four-way junction helicase activity
JC286_RS05835	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
JC286_RS05845	COG1862	Preprotein translocase
JC286_RS05850	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JC286_RS05850	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JC286_RS05855	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JC286_RS05855	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
JC286_RS05860	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JC286_RS05875	COG0860	N-Acetylmuramoyl-L-alanine amidase
JC286_RS05885	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JC286_RS05895	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JC286_RS05900	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JC286_RS05905	COG1959	2 iron, 2 sulfur cluster binding
JC286_RS05920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JC286_RS05925	COG1104	cysteine desulfurase activity
JC286_RS05930	COG0482	sulfurtransferase activity
JC286_RS05940	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JC286_RS05945	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JC286_RS05950	COG4472	Bacterial protein of unknown function (DUF965)
JC286_RS05955	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JC286_RS05960	COG3906	Belongs to the UPF0473 family
JC286_RS05965	COG4122	O-methyltransferase activity
JC286_RS05970	COG0826	peptidase U32
JC286_RS05975	COG0826	peptidase U32
JC286_RS05980	COG0572	uridine kinase
JC286_RS05990	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JC286_RS05995	COG1984	allophanate hydrolase subunit 2
JC286_RS06000	COG0511	ligase activity, forming carbon-carbon bonds
JC286_RS06005	COG0439	Biotin carboxylase
JC286_RS06010	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
JC286_RS06015	COG1914	H( )-stimulated, divalent metal cation uptake system
JC286_RS06020	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JC286_RS06025	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
JC286_RS06030	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
JC286_RS06035	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JC286_RS06040	COG1534	Rna-binding protein
JC286_RS06050	COG1713	HD superfamily hydrolase involved in NAD metabolism
JC286_RS06055	COG0799	negative regulation of ribosome biogenesis
JC286_RS06060	COG2226	methyltransferase
JC286_RS06065	COG1555	photosystem II stabilization
JC286_RS06065	COG1596	polysaccharide export
JC286_RS06070	COG2131	deaminase
JC286_RS06075	COG2333	competence protein COMEC
JC286_RS06075	COG0658	competence protein
JC286_RS06080	COG1466	dna polymerase III delta subunit
JC286_RS06085	COG0268	Binds directly to 16S ribosomal RNA
JC286_RS06095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JC286_RS06115	COG0484	heat shock protein binding
JC286_RS06120	COG2264	protein methyltransferase activity
JC286_RS06125	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JC286_RS06130	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JC286_RS06145	COG1030	water channel activity
JC286_RS06150	COG4864	UPF0365 protein
JC286_RS06160	COG1702	phosphate starvation-inducible protein PhoH
JC286_RS06170	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JC286_RS06180	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JC286_RS06185	COG1381	Involved in DNA repair and RecF pathway recombination
JC286_RS06190	COG0423	glycine-tRNA ligase activity
JC286_RS06195	COG0517	IMP dehydrogenase activity
JC286_RS06200	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JC286_RS06205	COG0358	DNA primase activity
JC286_RS06210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JC286_RS06215	COG2384	SAM-dependent methyltransferase
JC286_RS06220	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JC286_RS06225	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JC286_RS06230	COG0513	Belongs to the DEAD box helicase family
JC286_RS06235	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
JC286_RS06240	COG1121	(ABC) transporter
JC286_RS06245	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JC286_RS06250	COG0735	belongs to the Fur family
JC286_RS06255	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JC286_RS06265	COG0768	penicillin binding
JC286_RS06270	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JC286_RS06275	COG0573	inorganic phosphate transmembrane transporter activity
JC286_RS06280	COG0581	inorganic phosphate transmembrane transporter activity
JC286_RS06285	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JC286_RS06290	COG0704	Plays a role in the regulation of phosphate uptake
JC286_RS06300	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JC286_RS06305	COG0457	Tetratricopeptide repeat
JC286_RS06305	COG0705	Rhomboid family
JC286_RS06310	COG4483	Protein conserved in bacteria
JC286_RS06315	COG1940	carbohydrate kinase activity
JC286_RS06320	COG0011	TIGRFAM Protein of
JC286_RS06325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JC286_RS06330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JC286_RS06360	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JC286_RS06365	COG0404	The glycine cleavage system catalyzes the degradation of glycine
JC286_RS06375	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JC286_RS06380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JC286_RS06385	COG0095	Lipoate-protein ligase
JC286_RS06400	COG0006	proline dipeptidase activity
JC286_RS06405	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JC286_RS06410	COG0511	ligase activity, forming carbon-carbon bonds
JC286_RS06415	COG0439	Biotin carboxylase
JC286_RS06420	COG1302	Protein conserved in bacteria
JC286_RS06430	COG1570	exodeoxyribonuclease VII activity
JC286_RS06435	COG1722	exodeoxyribonuclease VII activity
JC286_RS06440	COG0142	geranyltranstransferase activity
JC286_RS06445	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JC286_RS06450	COG1438	arginine binding
JC286_RS06455	COG0497	DNA recombination
JC286_RS06460	COG0280	phosphate acetyltransferase
JC286_RS06465	COG3426	butyrate kinase activity
JC286_RS06470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JC286_RS06475	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
JC286_RS06480	COG0022	dehydrogenase e1 component
JC286_RS06485	COG0508	dehydrogenase complex catalyzes the overall conversion of
JC286_RS06495	COG4129	membrane
JC286_RS06505	COG2195	Cleaves the N-terminal amino acid of tripeptides
JC286_RS06530	COG2207	Transcriptional regulator
JC286_RS06530	COG3708	Transcriptional regulator
JC286_RS06535	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
JC286_RS06540	COG1234	tRNA 3'-trailer cleavage
JC286_RS06545	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JC286_RS06555	COG0667	Aldo Keto reductase
JC286_RS06560	COG0494	nUDIX hydrolase
JC286_RS06565	COG0735	belongs to the Fur family
JC286_RS06580	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
JC286_RS06585	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
JC286_RS06590	COG1187	pseudouridine synthase activity
JC286_RS06595	COG0745	RESPONSE REGULATOR receiver
JC286_RS06610	COG1141	Ferredoxin
JC286_RS06620	COG0514	ATP-dependent DNA helicase (RecQ)
JC286_RS06630	COG0492	ferredoxin-NADP+ reductase activity
JC286_RS06635	COG0252	asparaginase activity
JC286_RS06645	COG0539	negative regulation of cytoplasmic translation
JC286_RS06650	COG1160	GTP binding
JC286_RS06655	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JC286_RS06675	COG0142	geranyltranstransferase activity
JC286_RS06680	COG0105	UTP biosynthetic process
JC286_RS06690	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JC286_RS06700	COG0457	Tetratricopeptide repeat
JC286_RS06705	COG5582	Belongs to the UPF0302 family
JC286_RS06710	COG4347	Protein of unknown function (DUF1405)
JC286_RS06720	COG1694	Mazg nucleotide pyrophosphohydrolase
JC286_RS06725	COG0438	transferase activity, transferring glycosyl groups
JC286_RS06730	COG0617	tRNA 3'-terminal CCA addition
JC286_RS06745	COG0017	Asparaginyl-tRNA synthetase
JC286_RS06750	COG3935	DnaD domain protein
JC286_RS06755	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JC286_RS06765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JC286_RS06765	COG4499	WXG100 protein secretion system (Wss), protein YukC
JC286_RS06780	COG4474	Belongs to the UPF0398 family
JC286_RS06785	COG3599	regulation of cell shape
JC286_RS06795	COG0116	Belongs to the methyltransferase superfamily
JC286_RS06800	COG2962	Rard protein
JC286_RS06805	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
JC286_RS06810	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JC286_RS06820	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
JC286_RS06830	COG1413	lyase activity
JC286_RS06865	COG2190	(PTS) system
JC286_RS06875	COG0793	Belongs to the peptidase S41A family
JC286_RS06885	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JC286_RS06890	COG0671	phosphoesterase, PA-phosphatase related
JC286_RS06900	COG5002	protein histidine kinase activity
JC286_RS06905	COG0567	Dehydrogenase, E1 component
JC286_RS06930	COG0714	Associated with various cellular activities
JC286_RS06935	COG4548	von Willebrand factor, type A
JC286_RS06940	COG1114	Component of the transport system for branched-chain amino acids
JC286_RS06945	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JC286_RS06955	COG3853	Toxic anion resistance protein (TelA)
JC286_RS06975	COG1278	Cold shock
JC286_RS06995	COG1473	amidohydrolase
JC286_RS07000	COG2171	N-acyltransferase activity
JC286_RS07005	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JC286_RS07010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JC286_RS07015	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JC286_RS07020	COG0488	(ABC) transporter
JC286_RS07025	COG2996	Protein conserved in bacteria
JC286_RS07055	COG1363	Peptidase, m42
JC286_RS07060	COG0287	Prephenate dehydrogenase
JC286_RS07065	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JC286_RS07075	COG1942	4-Oxalocrotonate Tautomerase
JC286_RS07095	COG0628	permease
JC286_RS07105	COG3711	transcriptional antiterminator
JC286_RS07110	COG1115	amino acid carrier protein
JC286_RS07115	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JC286_RS07125	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
JC286_RS07130	COG4841	protein insertion into membrane
JC286_RS07135	COG0824	Thioesterase
JC286_RS07145	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JC286_RS07150	COG1970	mechanosensitive ion channel activity
JC286_RS07155	COG0419	ATPase involved in DNA repair
JC286_RS07160	COG0420	3'-5' exonuclease activity
JC286_RS07165	COG4846	Membrane protein involved in cytochrome C biogenesis
JC286_RS07170	COG3763	UPF0154 protein
JC286_RS07180	COG4224	UPF0291 protein
JC286_RS07190	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JC286_RS07200	COG0516	GMP reductase activity
JC286_RS07205	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JC286_RS07215	COG0833	amino acid
JC286_RS07230	COG0083	homoserine kinase activity
JC286_RS07235	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JC286_RS07240	COG0460	homoserine dehydrogenase
JC286_RS07245	COG0527	aspartate kinase activity
JC286_RS07265	COG1525	nuclease
JC286_RS07295	COG0584	glycerophosphoryl diester phosphodiesterase
JC286_RS07320	COG0789	Transcriptional regulator
JC286_RS07325	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
JC286_RS07330	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JC286_RS07335	COG0386	Belongs to the glutathione peroxidase family
JC286_RS07340	COG2267	carboxylic ester hydrolase activity
JC286_RS07345	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JC286_RS07350	COG1923	regulation of RNA biosynthetic process
JC286_RS07355	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JC286_RS07365	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JC286_RS07370	COG1619	proteins homologs of microcin C7 resistance protein MccF
JC286_RS07375	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
JC286_RS07380	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
JC286_RS07400	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JC286_RS07410	COG1013	pyruvate-flavodoxin oxidoreductase activity
JC286_RS07415	COG0674	pyruvate-flavodoxin oxidoreductase activity
JC286_RS07415	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JC286_RS07420	COG1692	metallophosphoesterase
JC286_RS07440	COG1418	mRNA catabolic process
JC286_RS07445	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JC286_RS07450	COG1058	Belongs to the CinA family
JC286_RS07450	COG1546	Belongs to the CinA family
JC286_RS07470	COG0300	oxidoreductase activity
JC286_RS07475	COG0612	Peptidase, M16
JC286_RS07480	COG0612	Peptidase, M16
JC286_RS07485	COG2188	Transcriptional regulator
JC286_RS07505	COG1185	polyribonucleotide nucleotidyltransferase activity
JC286_RS07515	COG0196	riboflavin kinase activity
JC286_RS07520	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JC286_RS07525	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JC286_RS07535	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JC286_RS07545	COG2740	Nucleic-acid-binding protein implicated in transcription termination
JC286_RS07550	COG0195	Participates in both transcription termination and antitermination
JC286_RS07555	COG0779	Required for maturation of 30S ribosomal subunits
JC286_RS07565	COG0442	prolyl-tRNA aminoacylation
JC286_RS07575	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
JC286_RS07580	COG4589	Belongs to the CDS family
JC286_RS07590	COG0233	cytoplasmic translational termination
JC286_RS07595	COG0528	UMP kinase activity
JC286_RS07600	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JC286_RS07605	COG0052	Belongs to the universal ribosomal protein uS2 family
JC286_RS07610	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
JC286_RS07615	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
JC286_RS07620	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
JC286_RS07625	COG4974	Belongs to the 'phage' integrase family
JC286_RS07630	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
JC286_RS07635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JC286_RS07640	COG0758	DNA mediated transformation
JC286_RS07650	COG0045	succinate-CoA ligase (ADP-forming) activity
JC286_RS07660	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JC286_RS07675	COG4485	Bacterial membrane protein, YfhO
JC286_RS07710	COG0336	Belongs to the RNA methyltransferase TrmD family
JC286_RS07715	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JC286_RS07720	COG0228	four-way junction DNA binding
JC286_RS07775	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JC286_RS07780	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
JC286_RS07785	COG0552	protein localization to endoplasmic reticulum
JC286_RS07790	COG1196	nuclear chromosome segregation
JC286_RS07795	COG0571	ribonuclease III activity
JC286_RS07800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JC286_RS07815	COG0416	fatty acid biosynthetic process
JC286_RS07820	COG1349	DNA-binding transcription factor activity
JC286_RS07830	COG1760	l-serine dehydratase
JC286_RS07835	COG1760	l-serine dehydratase
JC286_RS07845	COG1302	Protein conserved in bacteria
JC286_RS07860	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JC286_RS07865	COG1162	GTPase activity
JC286_RS07875	COG2124	cytochrome p450
JC286_RS07890	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JC286_RS07895	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JC286_RS07895	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JC286_RS07900	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JC286_RS07905	COG0242	peptide deformylase activity
JC286_RS07910	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JC286_RS07915	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JC286_RS07920	COG1758	RNA polymerase activity
JC286_RS07940	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JC286_RS07945	COG0284	orotidine-5'-phosphate decarboxylase activity
JC286_RS07950	COG0167	dihydroorotate dehydrogenase activity
JC286_RS07960	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JC286_RS07965	COG0505	Belongs to the CarA family
JC286_RS07985	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
JC286_RS07990	COG0564	pseudouridine synthase activity
JC286_RS07995	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JC286_RS08000	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JC286_RS08005	COG3599	regulation of cell shape
JC286_RS08020	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JC286_RS08025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JC286_RS08035	COG4975	Glucose uptake
JC286_RS08040	COG1869	D-ribose catabolic process
JC286_RS08050	COG0762	integral membrane protein
JC286_RS08055	COG1799	cell septum assembly
JC286_RS08060	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JC286_RS08070	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JC286_RS08075	COG0849	cell division
JC286_RS08085	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JC286_RS08095	COG0768	penicillin binding
JC286_RS08100	COG4839	cell division protein FtsL
JC286_RS08105	COG0275	rRNA processing
JC286_RS08110	COG2001	Belongs to the MraZ family
JC286_RS08115	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
JC286_RS08120	COG0454	-acetyltransferase
JC286_RS08125	COG1011	Hydrolase
JC286_RS08140	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JC286_RS08220	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JC286_RS08225	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JC286_RS08230	COG1053	succinate dehydrogenase
JC286_RS08235	COG2009	succinate dehydrogenase
JC286_RS08240	COG0322	excinuclease ABC activity
JC286_RS08245	COG3118	belongs to the thioredoxin family
JC286_RS08250	COG1193	negative regulation of DNA recombination
JC286_RS08255	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JC286_RS08255	COG1796	DNA polymerase
JC286_RS08270	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JC286_RS08285	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JC286_RS08290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JC286_RS08295	COG0333	Belongs to the bacterial ribosomal protein bL32 family
JC286_RS08315	COG0742	ribosomal rna small subunit methyltransferase
JC286_RS08325	COG4471	UPF0298 protein
JC286_RS08330	COG0584	glycerophosphoryl diester phosphodiesterase
JC286_RS08335	COG3679	Belongs to the UPF0342 family
JC286_RS08350	COG0109	protoheme IX farnesyltransferase activity
JC286_RS08365	COG3344	reverse transcriptase
JC286_RS08370	COG0772	Belongs to the SEDS family
JC286_RS08375	COG4838	Belongs to the UPF0358 family
JC286_RS08380	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
JC286_RS08385	COG4896	Protein conserved in bacteria
JC286_RS08390	COG1902	pentaerythritol trinitrate reductase activity
JC286_RS08395	COG1217	gtp-binding protein TYPA
JC286_RS08405	COG0483	inositol monophosphate 1-phosphatase activity
JC286_RS08410	COG4493	Belongs to the UPF0637 family
JC286_RS08425	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
JC286_RS08430	COG1177	transmembrane transport
JC286_RS08440	COG3842	ATPase activity
JC286_RS08450	COG4476	Belongs to the UPF0223 family
JC286_RS08490	COG5503	Protein of unknown function (DUF1447)
JC286_RS08495	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
JC286_RS08500	COG0569	domain protein
JC286_RS08505	COG1294	oxidase, subunit
JC286_RS08510	COG1271	oxidase subunit
JC286_RS08515	COG1393	Belongs to the ArsC family
JC286_RS08520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JC286_RS08525	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JC286_RS08535	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JC286_RS08555	COG4172	Belongs to the ABC transporter superfamily
JC286_RS08565	COG0151	Belongs to the GarS family
JC286_RS08570	COG0138	bifunctional purine biosynthesis protein purh
JC286_RS08580	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JC286_RS08585	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
JC286_RS08595	COG0047	phosphoribosylformylglycinamidine synthase activity
JC286_RS08600	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JC286_RS08605	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JC286_RS08610	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
JC286_RS08615	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JC286_RS08620	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JC286_RS08625	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JC286_RS08625	COG1017	nitric oxide dioxygenase activity
JC286_RS08635	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JC286_RS08645	COG1845	cytochrome c oxidase, subunit III
JC286_RS08650	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
JC286_RS08660	COG3212	peptidase
JC286_RS08675	COG1134	teichoic acid transport
JC286_RS08685	COG1682	transport, permease protein
JC286_RS08695	COG1215	transferase activity, transferring glycosyl groups
JC286_RS08705	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
JC286_RS08710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JC286_RS08715	COG1316	TRANSCRIPTIONal
JC286_RS08740	COG3594	Acyltransferase
JC286_RS08745	COG0436	Aminotransferase
JC286_RS08750	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
JC286_RS08760	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
JC286_RS08765	COG1169	isochorismate synthase
JC286_RS08770	COG1575	Belongs to the MenA family. Type 1 subfamily
JC286_RS08775	COG0390	transport system, permease component
JC286_RS08780	COG4619	ABC transporter
JC286_RS08790	COG3682	Transcriptional regulator
JC286_RS08820	COG4974	Belongs to the 'phage' integrase family
JC286_RS08840	COG4873	Protein conserved in bacteria
JC286_RS08880	COG5632	N-Acetylmuramoyl-L-alanine amidase
JC286_RS08880	COG1388	LysM domain
JC286_RS08920	COG0739	heme binding
JC286_RS08985	COG4626	Terminase
JC286_RS08985	COG1802	Transcriptional regulator
JC286_RS09150	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JC286_RS09180	COG3266	domain, Protein
JC286_RS09180	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
JC286_RS09180	COG4932	domain protein
JC286_RS09185	COG0737	Belongs to the 5'-nucleotidase family
JC286_RS09195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JC286_RS09200	COG1696	Membrane protein involved in D-alanine export
JC286_RS09210	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
JC286_RS09215	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JC286_RS09220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JC286_RS09225	COG0861	Integral membrane protein TerC family
JC286_RS09230	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
JC286_RS09240	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JC286_RS09245	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JC286_RS09250	COG2814	Major facilitator Superfamily
JC286_RS09260	COG3715	PTS system
JC286_RS09265	COG3716	PTS system mannose fructose sorbose family IID component
JC286_RS09270	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
JC286_RS09275	COG2382	esterase
JC286_RS09280	COG1115	amino acid carrier protein
JC286_RS09285	COG0628	permease
JC286_RS09290	COG4409	exo-alpha-(2->6)-sialidase activity
JC286_RS09295	COG2211	Major facilitator Superfamily
JC286_RS09300	COG0673	inositol 2-dehydrogenase activity
JC286_RS09310	COG0569	domain protein
JC286_RS09310	COG0475	glutathione-regulated potassium exporter activity
JC286_RS09315	COG2239	Acts as a magnesium transporter
JC286_RS09320	COG0564	pseudouridine synthase activity
JC286_RS09330	COG2357	RelA SpoT domain protein
JC286_RS09345	COG2346	COG2346, Truncated hemoglobins
JC286_RS09350	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
JC286_RS09360	COG1164	Oligoendopeptidase f
JC286_RS09385	COG1393	Belongs to the ArsC family
JC286_RS09390	COG0180	Tryptophanyl-tRNA synthetase
JC286_RS09395	COG4166	transmembrane transport
JC286_RS09400	COG4608	Belongs to the ABC transporter superfamily
JC286_RS09405	COG0444	Belongs to the ABC transporter superfamily
JC286_RS09410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JC286_RS09415	COG0601	transmembrane transport
JC286_RS09440	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
JC286_RS09460	COG0561	phosphatase activity
JC286_RS09465	COG0446	pyridine nucleotide-disulphide oxidoreductase
JC286_RS09475	COG0179	Fumarylacetoacetate (FAA) hydrolase
JC286_RS09485	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
JC286_RS09500	COG0166	Belongs to the GPI family
JC286_RS09505	COG0137	argininosuccinate synthase activity
JC286_RS09515	COG0584	glycerophosphoryl diester phosphodiesterase
JC286_RS09535	COG1012	belongs to the aldehyde dehydrogenase family
JC286_RS09540	COG1098	S1 RNA binding domain
JC286_RS09550	COG1278	Cold shock
JC286_RS09565	COG1131	(ABC) transporter
JC286_RS09595	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JC286_RS09605	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JC286_RS09605	COG2111	Na H antiporter
JC286_RS09610	COG2111	Na H antiporter
JC286_RS09615	COG1006	Multisubunit Na H antiporter MnhC subunit
JC286_RS09620	COG0651	ATP synthesis coupled electron transport
JC286_RS09625	COG1863	multisubunit Na H antiporter MnhE subunit
JC286_RS09630	COG2212	antiporter activity
JC286_RS09635	COG1320	monovalent cation:proton antiporter activity
JC286_RS09645	COG2056	Na+-H+ antiporter family
JC286_RS09650	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JC286_RS09655	COG1252	NADH dehydrogenase
JC286_RS09660	COG0316	Belongs to the HesB IscA family
JC286_RS09665	COG4844	belongs to the
JC286_RS09670	COG1252	NADH dehydrogenase
JC286_RS09675	COG4837	Protein of unknown function (DUF1462)
JC286_RS09680	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
JC286_RS09685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JC286_RS09690	COG0647	UMP catabolic process
JC286_RS09695	COG2445	Protein of unknown function DUF86
JC286_RS09705	COG4470	Protein conserved in bacteria
JC286_RS09710	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JC286_RS09715	COG0737	Belongs to the 5'-nucleotidase family
JC286_RS09720	COG0730	response to heat
JC286_RS09725	COG1801	Protein of unknown function DUF72
JC286_RS09740	COG1253	flavin adenine dinucleotide binding
JC286_RS09750	COG0719	Fe-S assembly protein
JC286_RS09755	COG0822	iron-sulfur transferase activity
JC286_RS09765	COG0719	Fe-S assembly protein
JC286_RS09770	COG0396	ATPase activity
JC286_RS09780	COG1464	Belongs to the NlpA lipoprotein family
JC286_RS09785	COG1464	Belongs to the NlpA lipoprotein family
JC286_RS09790	COG2011	ABC-type metal ion transport system permease component
JC286_RS09795	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JC286_RS09800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JC286_RS09805	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
JC286_RS09815	COG1393	Belongs to the ArsC family
JC286_RS09820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JC286_RS09830	COG0710	3-dehydroquinate dehydratase activity
JC286_RS09840	COG1764	response to oxidative stress
JC286_RS09855	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JC286_RS09875	COG0346	lactoylglutathione lyase activity
JC286_RS09905	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JC286_RS09935	COG0557	exoribonuclease II activity
JC286_RS09940	COG1647	Serine aminopeptidase, S33
JC286_RS09945	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JC286_RS09955	COG0148	phosphopyruvate hydratase activity
JC286_RS09960	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
JC286_RS09990	COG1090	epimerase
JC286_RS10000	COG0740	serine-type endopeptidase activity
JC286_RS10010	COG1481	regulation of sporulation
JC286_RS10015	COG0391	Required for morphogenesis under gluconeogenic growth conditions
JC286_RS10020	COG1660	Displays ATPase and GTPase activities
JC286_RS10035	COG0110	maltose O-acetyltransferase activity
JC286_RS10040	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JC286_RS10045	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
JC286_RS10080	COG0653	protein targeting
JC286_RS10095	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
JC286_RS10105	COG1739	Uncharacterized protein family UPF0029
JC286_RS10110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JC286_RS10130	COG2195	Cleaves the N-terminal amino acid of tripeptides
JC286_RS10140	COG1929	Belongs to the glycerate kinase type-1 family
JC286_RS10145	COG3118	belongs to the thioredoxin family
JC286_RS10160	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JC286_RS10170	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JC286_RS10175	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JC286_RS10205	COG3104	oligopeptide transport
JC286_RS10210	COG3104	oligopeptide transport
JC286_RS10225	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JC286_RS10230	COG1174	glycine betaine transport
JC286_RS10235	COG0517	IMP dehydrogenase activity
JC286_RS10235	COG1125	glycine betaine transport
JC286_RS10240	COG0514	ATP-dependent DNA helicase (RecQ)
JC286_RS10245	COG0488	(ABC) transporter
JC286_RS10255	COG1368	sulfuric ester hydrolase activity
JC286_RS10265	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JC286_RS10285	COG0512	Glutamine amidotransferase of anthranilate synthase
JC286_RS10295	COG0720	synthase
JC286_RS10300	COG0602	queuosine metabolic process
JC286_RS10315	COG0463	Glycosyl transferase, family 2
JC286_RS10320	COG1253	flavin adenine dinucleotide binding
JC286_RS10325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JC286_RS10325	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JC286_RS10325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JC286_RS10330	COG1105	Belongs to the carbohydrate kinase PfkB family
JC286_RS10335	COG1349	DNA-binding transcription factor activity
JC286_RS10355	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JC286_RS10360	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JC286_RS10380	COG0039	L-malate dehydrogenase activity
JC286_RS10400	COG4989	oxidoreductase activity
JC286_RS10405	COG0523	cobalamin synthesis protein
JC286_RS10415	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
JC286_RS10420	COG4988	ABC transporter
JC286_RS10425	COG1968	undecaprenyl-diphosphatase activity
JC286_RS10435	COG1671	Belongs to the UPF0178 family
JC286_RS10440	COG1611	Belongs to the LOG family
JC286_RS10470	COG2839	Protein conserved in bacteria
JC286_RS10475	COG2814	Major facilitator Superfamily
JC286_RS10480	COG0583	DNA-binding transcription factor activity
JC286_RS10495	COG0217	transcriptional regulatory protein
JC286_RS10500	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JC286_RS10505	COG2022	thiamine diphosphate biosynthetic process
JC286_RS10515	COG0352	thiamine-phosphate diphosphorylase activity
JC286_RS10525	COG1388	LysM domain
JC286_RS10525	COG3942	CHAP domain
JC286_RS10530	COG0306	phosphate transporter
JC286_RS10535	COG1392	Phosphate transport regulator
JC286_RS10540	COG0577	efflux transmembrane transporter activity
JC286_RS10545	COG1136	(ABC) transporter
JC286_RS10555	COG0745	RESPONSE REGULATOR receiver
JC286_RS10560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JC286_RS10565	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JC286_RS10575	COG3949	Membrane
JC286_RS10580	COG0477	Major facilitator Superfamily
JC286_RS10590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JC286_RS10595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JC286_RS10600	COG1120	ATPase activity
JC286_RS10605	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JC286_RS10610	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JC286_RS10630	COG1132	(ABC) transporter
JC286_RS10635	COG1686	Belongs to the peptidase S11 family
JC286_RS10650	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
JC286_RS10655	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JC286_RS10660	COG1682	transport, permease protein
JC286_RS10670	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
JC286_RS10685	COG1475	DNA binding
JC286_RS10690	COG0019	diaminopimelate decarboxylase activity
JC286_RS10700	COG4264	IucA IucC family
JC286_RS10705	COG4264	IucA IucC family
JC286_RS10710	COG2814	Major facilitator Superfamily
JC286_RS10715	COG4264	IucA IucC family
JC286_RS10720	COG2423	ornithine cyclodeaminase activity
JC286_RS10730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JC286_RS10735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JC286_RS10740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JC286_RS10750	COG1121	(ABC) transporter
JC286_RS10755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JC286_RS10760	COG0803	Belongs to the bacterial solute-binding protein 9 family
JC286_RS10765	COG1320	monovalent cation:proton antiporter activity
JC286_RS10770	COG2212	antiporter activity
JC286_RS10775	COG1863	multisubunit Na H antiporter MnhE subunit
JC286_RS10785	COG1006	Multisubunit Na H antiporter MnhC subunit
JC286_RS10790	COG2111	Na H antiporter
JC286_RS10795	COG2111	Na H antiporter
JC286_RS10795	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JC286_RS10845	COG0546	phosphoglycolate phosphatase activity
JC286_RS10850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JC286_RS10855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JC286_RS10860	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JC286_RS10865	COG0805	protein transport
JC286_RS10870	COG0018	arginyl-trna synthetase
JC286_RS10885	COG1078	dGTPase activity
JC286_RS10895	COG4844	belongs to the
JC286_RS10950	COG0471	metal ion transport
JC286_RS10975	COG0280	phosphate acetyltransferase
JC286_RS10980	COG0095	Lipoate-protein ligase
JC286_RS11000	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JC286_RS11005	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
JC286_RS11015	COG2814	Major facilitator Superfamily
JC286_RS11020	COG1566	PFAM secretion protein HlyD family protein
JC286_RS11030	COG2311	Membrane
JC286_RS11045	COG2363	Small membrane protein
JC286_RS11075	COG0183	Belongs to the thiolase family
JC286_RS11080	COG0318	PFAM AMP-dependent synthetase and ligase
JC286_RS11085	COG0588	phosphoglycerate mutase activity
JC286_RS11090	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JC286_RS11100	COG2814	Major facilitator Superfamily
JC286_RS11110	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JC286_RS11120	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
JC286_RS11135	COG1263	PTS System
JC286_RS11135	COG2190	(PTS) system
JC286_RS11135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JC286_RS11150	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JC286_RS11155	COG1469	GTP cyclohydrolase I activity
JC286_RS11160	COG1136	(ABC) transporter
JC286_RS11160	COG0577	efflux transmembrane transporter activity
JC286_RS11175	COG0561	phosphatase activity
JC286_RS11185	COG1428	Deoxynucleoside kinase
JC286_RS11190	COG1428	Deoxynucleoside kinase
JC286_RS11195	COG0546	phosphoglycolate phosphatase activity
JC286_RS11210	COG0488	(ABC) transporter
JC286_RS11215	COG1121	(ABC) transporter
JC286_RS11230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JC286_RS11240	COG1473	amidohydrolase
JC286_RS11245	COG3527	Alpha-acetolactate decarboxylase
JC286_RS11250	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JC286_RS11255	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JC286_RS11260	COG0049	tRNA binding
JC286_RS11265	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JC286_RS11275	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JC286_RS11280	COG0085	RNA polymerase activity
JC286_RS11285	COG2813	Specifically methylates the guanine in position
JC286_RS11295	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JC286_RS11300	COG0081	regulation of translation
JC286_RS11305	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JC286_RS11310	COG0250	Participates in transcription elongation, termination and antitermination
JC286_RS11315	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JC286_RS11320	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JC286_RS11340	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
JC286_RS11345	COG0215	cysteine-tRNA ligase activity
JC286_RS11350	COG1045	serine acetyltransferase
JC286_RS11355	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JC286_RS11365	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JC286_RS11370	COG4956	integral membrane protein (PIN domain superfamily)
JC286_RS11375	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JC286_RS11410	COG0542	response to heat
JC286_RS11415	COG3869	Catalyzes the specific phosphorylation of arginine residues in
JC286_RS11420	COG3880	PFAM UvrB UvrC protein
JC286_RS11430	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JC286_RS11440	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
JC286_RS11445	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
JC286_RS11450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JC286_RS11455	COG1289	transmembrane transporter activity
JC286_RS11545	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JC286_RS11550	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JC286_RS11570	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
JC286_RS11575	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JC286_RS11590	COG1098	S1 RNA binding domain
JC286_RS11600	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
JC286_RS11605	COG3956	TIGRFAM MazG family protein
JC286_RS11610	COG2244	polysaccharide biosynthetic process
JC286_RS11615	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JC286_RS11620	COG0193	aminoacyl-tRNA hydrolase activity
JC286_RS11630	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JC286_RS11635	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JC286_RS11640	COG2088	sporulation resulting in formation of a cellular spore
JC286_RS11645	COG0251	oxidation-reduction process
JC286_RS11650	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JC286_RS11655	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JC286_RS11660	COG4466	Protein conserved in bacteria
JC286_RS11670	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
JC286_RS11675	COG0084	hydrolase, TatD family'
JC286_RS11685	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
JC286_RS11690	COG2827	Endonuclease containing a URI domain
JC286_RS11695	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
JC286_RS11700	COG4467	Involved in initiation control of chromosome replication
JC286_RS11705	COG1774	PSP1 C-terminal conserved region
JC286_RS11710	COG0470	DNA polymerase III
JC286_RS11715	COG3870	Protein conserved in bacteria
JC286_RS11720	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JC286_RS11725	COG1982	Orn Lys Arg decarboxylase major
JC286_RS11750	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JC286_RS11755	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JC286_RS11760	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JC286_RS11765	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JC286_RS11775	COG2188	Transcriptional regulator
JC286_RS11780	COG0366	Alpha amylase catalytic
JC286_RS11785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JC286_RS11785	COG1263	PTS System
JC286_RS11795	COG0493	'glutamate synthase
JC286_RS11800	COG0070	glutamate synthase
JC286_RS11800	COG0067	glutamate synthase
JC286_RS11800	COG0069	glutamate synthase activity
JC286_RS11805	COG0583	DNA-binding transcription factor activity
JC286_RS11820	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JC286_RS11845	COG0626	cystathionine gamma-synthase activity
JC286_RS11850	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JC286_RS11855	COG2272	Belongs to the type-B carboxylesterase lipase family
JC286_RS11860	COG0733	neurotransmitter:sodium symporter activity
JC286_RS11870	COG0745	RESPONSE REGULATOR receiver
JC286_RS11875	COG2205	protein histidine kinase activity
JC286_RS11885	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
JC286_RS11890	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
JC286_RS11915	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JC286_RS11920	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JC286_RS11920	COG0574	Belongs to the PEP-utilizing enzyme family
JC286_RS11950	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
JC286_RS11960	COG1486	melibiose metabolic process
JC286_RS11965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JC286_RS11965	COG1263	PTS System
JC286_RS11985	COG2210	Belongs to the sulfur carrier protein TusA family
JC286_RS11990	COG1937	Protein conserved in bacteria
JC286_RS11995	COG0730	response to heat
JC286_RS12000	COG2814	Major facilitator Superfamily
JC286_RS12015	COG1124	(ABC) transporter
JC286_RS12020	COG0444	Belongs to the ABC transporter superfamily
JC286_RS12025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JC286_RS12030	COG0601	transmembrane transport
JC286_RS12035	COG0747	negative chemotaxis
JC286_RS12060	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
JC286_RS12080	COG1525	nuclease
JC286_RS12115	COG3728	DNA packaging
JC286_RS12115	COG5484	DNA packaging
JC286_RS12190	COG0519	Catalyzes the synthesis of GMP from XMP
JC286_RS12190	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JC286_RS12195	COG0516	GMP reductase activity
JC286_RS12195	COG0517	IMP dehydrogenase activity
JC286_RS12200	COG2233	PERMEase
JC286_RS12205	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JC286_RS12220	COG5183	chlorophyll binding
JC286_RS12225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JC286_RS12230	COG1823	symporter activity
JC286_RS12235	COG1136	(ABC) transporter
JC286_RS12235	COG0577	efflux transmembrane transporter activity
JC286_RS12250	COG0778	Nitroreductase
JC286_RS12255	COG0450	alkyl hydroperoxide reductase
JC286_RS12270	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JC286_RS12280	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JC286_RS12285	COG2011	ABC-type metal ion transport system permease component
JC286_RS12290	COG1464	Belongs to the NlpA lipoprotein family
JC286_RS12295	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JC286_RS12300	COG0753	catalase activity
JC286_RS12310	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JC286_RS12320	COG0360	Binds together with S18 to 16S ribosomal RNA
JC286_RS12330	COG1668	transmembrane transport
JC286_RS12335	COG1131	(ABC) transporter
JC286_RS12350	COG0012	GTP binding
JC286_RS12355	COG4481	Protein conserved in bacteria
JC286_RS12360	COG0668	transmembrane transport
JC286_RS12365	COG1475	DNA binding
JC286_RS12370	COG0626	cystathionine gamma-synthase activity
JC286_RS12375	COG0626	cystathionine gamma-synthase activity
JC286_RS12380	COG0646	methionine synthase
JC286_RS12380	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
JC286_RS12385	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JC286_RS12390	COG0829	nickel cation binding
JC286_RS12400	COG0830	nickel cation binding
JC286_RS12405	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
JC286_RS12415	COG2388	GCN5-related N-acetyl-transferase
JC286_RS12420	COG1846	Transcriptional regulator
JC286_RS12425	COG0346	lactoylglutathione lyase activity
JC286_RS12430	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JC286_RS12435	COG0400	carboxylic ester hydrolase activity
JC286_RS12460	COG0357	Ribosomal RNA small subunit methyltransferase G
JC286_RS12465	COG0445	tRNA wobble uridine modification
JC286_RS12470	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
JC286_RS12475	COG0594	ribonuclease P activity