locus-tag	class	description
JC281_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JC281_RS00010	COG0592	DNA-directed DNA polymerase activity
JC281_RS00015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JC281_RS00015	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JC281_RS00020	COG2501	S4 domain
JC281_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JC281_RS00030	COG0187	DNA topoisomerase II activity
JC281_RS00040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JC281_RS00045	COG2986	histidine ammonia-lyase
JC281_RS00055	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
JC281_RS00065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JC281_RS00070	COG4241	membrane
JC281_RS00075	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
JC281_RS00080	COG0359	binds to the 23S rRNA
JC281_RS00085	COG0305	Participates in initiation and elongation during chromosome replication
JC281_RS00090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JC281_RS00095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JC281_RS00115	COG0745	RESPONSE REGULATOR receiver
JC281_RS00120	COG5002	protein histidine kinase activity
JC281_RS00125	COG4863	YycH protein
JC281_RS00135	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
JC281_RS00180	COG2311	Membrane
JC281_RS00200	COG0531	amino acid
JC281_RS00205	COG2217	Heavy metal translocating P-type atpase
JC281_RS00240	COG2188	Transcriptional regulator
JC281_RS00245	COG2723	6-phospho-beta-galactosidase activity
JC281_RS00255	COG0415	Belongs to the DNA photolyase family
JC281_RS00270	COG0702	epimerase
JC281_RS00275	COG2130	NADP-dependent
JC281_RS00290	COG3177	Filamentation induced by cAMP protein fic
JC281_RS00295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JC281_RS00300	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JC281_RS00300	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JC281_RS00305	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
JC281_RS00310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JC281_RS00330	COG2235	arginine
JC281_RS00345	COG2197	response regulator
JC281_RS00350	COG2203	Gaf domain
JC281_RS00350	COG4585	Histidine kinase
JC281_RS00355	COG0842	Transport permease protein
JC281_RS00360	COG1131	(ABC) transporter
JC281_RS00380	COG0431	NADPH-dependent FMN reductase
JC281_RS00405	COG1609	Transcriptional regulator
JC281_RS00415	COG0673	inositol 2-dehydrogenase activity
JC281_RS00425	COG0366	Alpha amylase catalytic
JC281_RS00435	COG3833	ABC-type maltose transport systems, permease component
JC281_RS00440	COG1175	transmembrane transport
JC281_RS00450	COG3842	ATPase activity
JC281_RS00455	COG0475	glutathione-regulated potassium exporter activity
JC281_RS00460	COG0490	domain, Protein
JC281_RS00470	COG0346	lactoylglutathione lyase activity
JC281_RS00500	COG1131	(ABC) transporter
JC281_RS00510	COG0366	Alpha amylase catalytic
JC281_RS00515	COG2188	Transcriptional regulator
JC281_RS00520	COG2222	sugar isomerase
JC281_RS00525	COG1105	Belongs to the carbohydrate kinase PfkB family
JC281_RS00540	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
JC281_RS00540	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JC281_RS00545	COG3715	PTS system
JC281_RS00550	COG3716	PTS system mannose fructose sorbose family IID component
JC281_RS00560	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JC281_RS00580	COG3314	Sporulation integral membrane protein YlbJ
JC281_RS00600	COG1063	alcohol dehydrogenase
JC281_RS00615	COG1620	l-lactate permease
JC281_RS00620	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
JC281_RS00625	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JC281_RS00630	COG0156	8-amino-7-oxononanoate synthase activity
JC281_RS00675	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
JC281_RS00690	COG0076	glutamate decarboxylase activity
JC281_RS00705	COG2318	DinB family
JC281_RS00710	COG0753	catalase activity
JC281_RS00720	COG0783	Belongs to the Dps family
JC281_RS00730	COG0436	Aminotransferase
JC281_RS00755	COG1136	(ABC) transporter
JC281_RS00765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JC281_RS00770	COG3344	reverse transcriptase
JC281_RS00785	COG1755	Isoprenylcysteine carboxyl methyltransferase
JC281_RS00810	COG0579	oxidoreductase
JC281_RS00830	COG1073	alpha beta
JC281_RS00850	COG0438	transferase activity, transferring glycosyl groups
JC281_RS00855	COG0183	Belongs to the thiolase family
JC281_RS00870	COG0318	PFAM AMP-dependent synthetase and ligase
JC281_RS00880	COG2814	Major facilitator Superfamily
JC281_RS00890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JC281_RS00920	COG1609	Transcriptional regulator
JC281_RS00925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JC281_RS00930	COG1869	D-ribose catabolic process
JC281_RS00960	COG3711	transcriptional antiterminator
JC281_RS00965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JC281_RS00975	COG3037	sugar-specific permease SgaT UlaA
JC281_RS00985	COG1328	CTP reductase activity
JC281_RS01005	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JC281_RS01010	COG1942	4-Oxalocrotonate Tautomerase
JC281_RS01020	COG3443	Belongs to the bacterial solute-binding protein 9 family
JC281_RS01020	COG0803	Belongs to the bacterial solute-binding protein 9 family
JC281_RS01045	COG4753	response regulator
JC281_RS01045	COG2207	Transcriptional regulator
JC281_RS01050	COG2972	Histidine kinase
JC281_RS01065	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JC281_RS01070	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JC281_RS01075	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
JC281_RS01080	COG0477	Major facilitator Superfamily
JC281_RS01085	COG2211	Major facilitator Superfamily
JC281_RS01090	COG3250	beta-galactosidase activity
JC281_RS01095	COG1957	nucleoside hydrolase
JC281_RS01110	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
JC281_RS01115	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
JC281_RS01120	COG2807	transmembrane transport
JC281_RS01125	COG1396	sequence-specific DNA binding
JC281_RS01140	COG1785	Belongs to the alkaline phosphatase family
JC281_RS01145	COG0494	nUDIX hydrolase
JC281_RS01150	COG0556	nucleotide-excision repair
JC281_RS01165	COG1510	regulation of RNA biosynthetic process
JC281_RS01170	COG1012	belongs to the aldehyde dehydrogenase family
JC281_RS01175	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
JC281_RS01180	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JC281_RS01190	COG0156	8-amino-7-oxononanoate synthase activity
JC281_RS01205	COG0107	imidazoleglycerol-phosphate synthase activity
JC281_RS01210	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JC281_RS01225	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JC281_RS01230	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JC281_RS01235	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JC281_RS01240	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
JC281_RS01275	COG2376	Dihydroxyacetone kinase
JC281_RS01280	COG1461	Dihydroxyacetone kinase
JC281_RS01285	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
JC281_RS01290	COG2824	Alkylphosphonate utilization operon protein PhnA
JC281_RS01295	COG1012	belongs to the aldehyde dehydrogenase family
JC281_RS01325	COG1131	(ABC) transporter
JC281_RS01335	COG1131	(ABC) transporter
JC281_RS01340	COG1668	transmembrane transport
JC281_RS01365	COG0596	Alpha beta hydrolase
JC281_RS01375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JC281_RS01375	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JC281_RS01375	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JC281_RS01385	COG1705	Flagellar rod assembly protein muramidase FlgJ
JC281_RS01385	COG3942	CHAP domain
JC281_RS01395	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JC281_RS01400	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JC281_RS01405	COG0747	negative chemotaxis
JC281_RS01430	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JC281_RS01430	COG0463	Glycosyl transferase, family 2
JC281_RS01445	COG0778	Nitroreductase
JC281_RS01450	COG3001	Fructosamine kinase
JC281_RS01475	COG1136	(ABC) transporter
JC281_RS01480	COG0577	efflux transmembrane transporter activity
JC281_RS01490	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
JC281_RS01500	COG4413	Urea transporter
JC281_RS01510	COG0832	Belongs to the urease beta subunit family
JC281_RS01515	COG0804	urea catabolic process
JC281_RS01520	COG0717	Belongs to the dCTP deaminase family
JC281_RS01525	COG0523	cobalamin synthesis protein
JC281_RS01535	COG1141	Ferredoxin
JC281_RS01560	COG0583	DNA-binding transcription factor activity
JC281_RS01570	COG1346	cytolysis
JC281_RS01585	COG1846	Transcriptional regulator
JC281_RS01590	COG0778	Nitroreductase
JC281_RS01595	COG2357	RelA SpoT domain protein
JC281_RS01635	COG1028	Short-chain dehydrogenase reductase Sdr
JC281_RS01650	COG3835	regulator
JC281_RS01655	COG2855	membrane
JC281_RS01660	COG3961	Belongs to the TPP enzyme family
JC281_RS01665	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JC281_RS01670	COG0512	Glutamine amidotransferase of anthranilate synthase
JC281_RS01680	COG0134	indole-3-glycerol-phosphate synthase activity
JC281_RS01690	COG0133	tryptophan synthase activity
JC281_RS01695	COG0159	tryptophan synthase activity
JC281_RS01715	COG0277	FAD linked oxidase domain protein
JC281_RS01720	COG0247	lactate metabolic process
JC281_RS01725	COG1132	(ABC) transporter
JC281_RS01730	COG1132	(ABC) transporter
JC281_RS01735	COG0789	Transcriptional regulator
JC281_RS01740	COG3871	stress protein (general stress protein 26)
JC281_RS01745	COG1115	amino acid carrier protein
JC281_RS01750	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
JC281_RS01755	COG2814	Major facilitator Superfamily
JC281_RS01760	COG2271	Major facilitator Superfamily
JC281_RS01765	COG3764	Sortase (surface protein transpeptidase)
JC281_RS01770	COG1929	Belongs to the glycerate kinase type-1 family
JC281_RS01780	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
JC281_RS01800	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JC281_RS01805	COG0702	epimerase
JC281_RS01810	COG4166	transmembrane transport
JC281_RS01815	COG0444	Belongs to the ABC transporter superfamily
JC281_RS01820	COG4608	Belongs to the ABC transporter superfamily
JC281_RS01825	COG0601	transmembrane transport
JC281_RS01830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JC281_RS01835	COG4166	transmembrane transport
JC281_RS01840	COG0444	Belongs to the ABC transporter superfamily
JC281_RS01845	COG4608	Belongs to the ABC transporter superfamily
JC281_RS01850	COG0601	transmembrane transport
JC281_RS01855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JC281_RS01865	COG1760	l-serine dehydratase
JC281_RS01870	COG1760	l-serine dehydratase
JC281_RS01900	COG0471	metal ion transport
JC281_RS01905	COG2116	formate transmembrane transporter activity
JC281_RS01910	COG0454	-acetyltransferase
JC281_RS01920	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JC281_RS01920	COG1648	precorrin-2 dehydrogenase activity
JC281_RS01925	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JC281_RS01930	COG2146	nitrite reductase [NAD(P)H] activity
JC281_RS01935	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JC281_RS01935	COG1648	precorrin-2 dehydrogenase activity
JC281_RS01940	COG0737	Belongs to the 5'-nucleotidase family
JC281_RS01950	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
JC281_RS01955	COG1140	nitrate reductase beta subunit
JC281_RS01965	COG2181	nitrate reductase activity
JC281_RS01975	COG4585	Histidine kinase
JC281_RS01980	COG2197	response regulator
JC281_RS01985	COG2223	nitrite transmembrane transporter activity
JC281_RS01990	COG4187	Peptidase family M20/M25/M40
JC281_RS02000	COG0039	L-malate dehydrogenase activity
JC281_RS02005	COG1363	Peptidase, m42
JC281_RS02015	COG3344	reverse transcriptase
JC281_RS02030	COG2807	transmembrane transport
JC281_RS02040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JC281_RS02040	COG1263	PTS System
JC281_RS02055	COG1283	sodium-dependent phosphate transmembrane transporter activity
JC281_RS02075	COG0492	ferredoxin-NADP+ reductase activity
JC281_RS02080	COG2814	Major facilitator Superfamily
JC281_RS02085	COG0604	alcohol dehydrogenase
JC281_RS02100	COG1620	l-lactate permease
JC281_RS02105	COG0438	transferase activity, transferring glycosyl groups
JC281_RS02110	COG0579	oxidoreductase
JC281_RS02125	COG0577	efflux transmembrane transporter activity
JC281_RS02160	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
JC281_RS02170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JC281_RS02190	COG1304	FMN binding
JC281_RS02195	COG0523	cobalamin synthesis protein
JC281_RS02200	COG0786	glutamate:sodium symporter activity
JC281_RS02205	COG2207	Transcriptional regulator
JC281_RS02210	COG3250	beta-galactosidase activity
JC281_RS02230	COG1757	Na H antiporter
JC281_RS02235	COG2094	Belongs to the DNA glycosylase MPG family
JC281_RS02240	COG3152	Membrane
JC281_RS02245	COG4152	abc transporter atp-binding protein
JC281_RS02250	COG1668	transmembrane transport
JC281_RS02255	COG1742	UPF0060 membrane protein
JC281_RS02260	COG2017	converts alpha-aldose to the beta-anomer
JC281_RS02265	COG2258	MOSC domain
JC281_RS02270	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
JC281_RS02280	COG1266	CAAX protease self-immunity
JC281_RS02285	COG0583	DNA-binding transcription factor activity
JC281_RS02290	COG3314	Sporulation integral membrane protein YlbJ
JC281_RS02295	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
JC281_RS02300	COG1228	amidohydrolase
JC281_RS02305	COG0659	secondary active sulfate transmembrane transporter activity
JC281_RS02310	COG1473	amidohydrolase
JC281_RS02330	COG0385	Bile acid
JC281_RS02340	COG0346	lactoylglutathione lyase activity
JC281_RS02345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JC281_RS02370	COG1113	amino acid transport
JC281_RS02395	COG1316	TRANSCRIPTIONal
JC281_RS02410	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
JC281_RS02415	COG3383	formate dehydrogenase (NAD+) activity
JC281_RS02440	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JC281_RS02445	COG2076	Multidrug Resistance protein
JC281_RS02450	COG2076	Multidrug Resistance protein
JC281_RS02455	COG3942	CHAP domain
JC281_RS02465	COG1757	Na H antiporter
JC281_RS02475	COG3942	CHAP domain
JC281_RS02495	COG1960	acyl-CoA dehydrogenase activity
JC281_RS02500	COG2832	Protein of unknown function (DUF454)
JC281_RS02505	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JC281_RS02510	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JC281_RS02520	COG2186	Transcriptional regulator
JC281_RS02530	COG1268	BioY protein
JC281_RS02550	COG1609	Transcriptional regulator
JC281_RS02555	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JC281_RS02560	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JC281_RS02565	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
JC281_RS02570	COG0725	ABC transporter, periplasmic molybdate-binding protein
JC281_RS02575	COG4149	molybdate abc transporter
JC281_RS02580	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
JC281_RS02585	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JC281_RS02590	COG0521	Mo-molybdopterin cofactor biosynthetic process
JC281_RS02610	COG0314	molybdopterin synthase activity
JC281_RS02620	COG0746	molybdenum cofactor guanylyltransferase activity
JC281_RS02625	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JC281_RS02650	COG2348	transferase activity, transferring amino-acyl groups
JC281_RS02655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JC281_RS02660	COG0436	Aminotransferase
JC281_RS02690	COG2252	PERMEase
JC281_RS02710	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JC281_RS02715	COG0088	Forms part of the polypeptide exit tunnel
JC281_RS02720	COG0089	rRNA binding
JC281_RS02725	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JC281_RS02730	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JC281_RS02735	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JC281_RS02740	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JC281_RS02745	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JC281_RS02750	COG0255	Belongs to the universal ribosomal protein uL29 family
JC281_RS02760	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JC281_RS02775	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JC281_RS02780	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JC281_RS02785	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JC281_RS02795	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JC281_RS02800	COG1841	ribosomal large subunit assembly
JC281_RS02810	COG0201	protein transport
JC281_RS02825	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JC281_RS02835	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JC281_RS02840	COG0202	RNA polymerase activity
JC281_RS02845	COG0203	ribosomal protein L17
JC281_RS02850	COG1122	ATPase activity
JC281_RS02855	COG1122	ATPase activity
JC281_RS02865	COG0101	tRNA pseudouridine synthase activity
JC281_RS02870	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JC281_RS02895	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JC281_RS02905	COG1335	isochorismatase
JC281_RS02910	COG1349	DNA-binding transcription factor activity
JC281_RS02925	COG3684	Belongs to the aldolase LacD family
JC281_RS02935	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JC281_RS02935	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JC281_RS02945	COG0488	(ABC) transporter
JC281_RS02950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JC281_RS02960	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JC281_RS02975	COG1302	Protein conserved in bacteria
JC281_RS02980	COG2814	Major facilitator Superfamily
JC281_RS02985	COG4264	IucA IucC family
JC281_RS02990	COG2814	Major facilitator Superfamily
JC281_RS02995	COG4264	IucA IucC family
JC281_RS03000	COG3457	Alanine racemase
JC281_RS03005	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
JC281_RS03010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JC281_RS03015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JC281_RS03020	COG3314	Sporulation integral membrane protein YlbJ
JC281_RS03030	COG1988	membrane-bound metal-dependent
JC281_RS03035	COG4284	Utp--glucose-1-phosphate uridylyltransferase
JC281_RS03040	COG1272	protein, Hemolysin III
JC281_RS03060	COG2814	Major facilitator Superfamily
JC281_RS03065	COG0489	protein tyrosine kinase activity
JC281_RS03130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JC281_RS03135	COG0246	Mannitol dehydrogenase
JC281_RS03145	COG3711	transcriptional antiterminator
JC281_RS03175	COG1119	ATPase activity
JC281_RS03180	COG0561	phosphatase activity
JC281_RS03190	COG2186	Transcriptional regulator
JC281_RS03195	COG1482	cell wall glycoprotein biosynthetic process
JC281_RS03210	COG1757	Na H antiporter
JC281_RS03220	COG0813	purine-nucleoside phosphorylase activity
JC281_RS03255	COG5146	pantothenate kinase activity
JC281_RS03270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JC281_RS03275	COG3343	RNA polymerase activity
JC281_RS03280	COG0504	CTP synthase activity
JC281_RS03285	COG2271	Major facilitator Superfamily
JC281_RS03290	COG4821	SIS domain
JC281_RS03295	COG0191	fructose-bisphosphate aldolase activity
JC281_RS03300	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JC281_RS03305	COG1733	regulation of RNA biosynthetic process
JC281_RS03315	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
JC281_RS03320	COG0254	rRNA binding
JC281_RS03330	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JC281_RS03335	COG2890	protein-(glutamine-N5) methyltransferase activity
JC281_RS03340	COG0009	L-threonylcarbamoyladenylate synthase
JC281_RS03345	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JC281_RS03350	COG4475	Protein of unknown function (DUF436)
JC281_RS03355	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JC281_RS03360	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JC281_RS03365	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
JC281_RS03375	COG0356	it plays a direct role in the translocation of protons across the membrane
JC281_RS03380	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JC281_RS03390	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JC281_RS03400	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JC281_RS03430	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JC281_RS03445	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
JC281_RS03455	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
JC281_RS03460	COG0352	thiamine-phosphate diphosphorylase activity
JC281_RS03465	COG0706	membrane insertase activity
JC281_RS03470	COG1418	mRNA catabolic process
JC281_RS03475	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JC281_RS03480	COG1937	Protein conserved in bacteria
JC281_RS03495	COG2217	Heavy metal translocating P-type atpase
JC281_RS03510	COG0772	Belongs to the SEDS family
JC281_RS03515	COG1181	Belongs to the D-alanine--D-alanine ligase family
JC281_RS03520	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JC281_RS03525	COG0513	Belongs to the DEAD box helicase family
JC281_RS03540	COG3402	PFAM membrane-flanked domain
JC281_RS03545	COG0736	holo-[acyl-carrier-protein] synthase activity
JC281_RS03550	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JC281_RS03560	COG2337	Toxic component of a toxin-antitoxin (TA) module
JC281_RS03565	COG2208	phosphoserine phosphatase activity
JC281_RS03570	COG1366	Belongs to the anti-sigma-factor antagonist family
JC281_RS03580	COG1191	sigma factor activity
JC281_RS03585	COG2183	response to ionizing radiation
JC281_RS03590	COG3091	SprT-like family
JC281_RS03650	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JC281_RS03660	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JC281_RS03665	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JC281_RS03675	COG0028	Belongs to the TPP enzyme family
JC281_RS03680	COG0129	dihydroxy-acid dehydratase activity
JC281_RS03685	COG0802	atpase or kinase
JC281_RS03690	COG1214	PFAM Peptidase M22, glycoprotease
JC281_RS03695	COG0456	acetyltransferase
JC281_RS03700	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JC281_RS03710	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JC281_RS03715	COG0488	(ABC) transporter
JC281_RS03720	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
JC281_RS03725	COG2814	Major facilitator Superfamily
JC281_RS03730	COG1846	Transcriptional regulator
JC281_RS03740	COG2124	cytochrome p450
JC281_RS03750	COG1609	Transcriptional regulator
JC281_RS03755	COG1621	beta-fructofuranosidase activity
JC281_RS03760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JC281_RS03785	COG4512	PFAM Accessory gene regulator B
JC281_RS03830	COG1404	Belongs to the peptidase S8 family
JC281_RS03835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JC281_RS03840	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JC281_RS03860	COG1131	(ABC) transporter
JC281_RS03875	COG1070	Carbohydrate kinase
JC281_RS03880	COG2610	gluconate transmembrane transporter activity
JC281_RS03915	COG2706	6-phosphogluconolactonase activity
JC281_RS03920	COG1012	belongs to the aldehyde dehydrogenase family
JC281_RS03930	COG1227	inorganic diphosphatase activity
JC281_RS03935	COG1335	isochorismatase
JC281_RS03945	COG0077	Prephenate dehydratase
JC281_RS03945	COG1605	Chorismate mutase
JC281_RS03955	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
JC281_RS03965	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
JC281_RS03975	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JC281_RS03980	COG4496	protein, YerC YecD
JC281_RS03985	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
JC281_RS03990	COG0210	DNA helicase
JC281_RS03995	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JC281_RS04000	COG4851	CamS sex pheromone cAM373 precursor
JC281_RS04005	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JC281_RS04010	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JC281_RS04020	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JC281_RS04025	COG1597	lipid kinase activity
JC281_RS04050	COG0488	(ABC) transporter
JC281_RS04060	COG1396	sequence-specific DNA binding
JC281_RS04070	COG2211	Major facilitator Superfamily
JC281_RS04080	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JC281_RS04090	COG1528	Iron-storage protein
JC281_RS04105	COG4129	membrane
JC281_RS04110	COG0024	Methionine aminopeptidase
JC281_RS04135	COG0288	reversible hydration of carbon dioxide
JC281_RS04140	COG1295	ribonuclease BN
JC281_RS04155	COG4840	Belongs to the UPF0435 family
JC281_RS04160	COG2309	aminopeptidase activity
JC281_RS04165	COG1607	acyl-coa hydrolase
JC281_RS04170	COG0535	radical SAM domain protein
JC281_RS04180	COG0693	protein deglycase activity
JC281_RS04185	COG0028	Belongs to the TPP enzyme family
JC281_RS04190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JC281_RS04195	COG2137	regulation of response to DNA damage stimulus
JC281_RS04205	COG1134	teichoic acid transport
JC281_RS04205	COG1388	LysM domain
JC281_RS04215	COG1988	membrane-bound metal-dependent
JC281_RS04220	COG1194	a g-specific adenine glycosylase
JC281_RS04225	COG3557	Belongs to the UPF0374 family
JC281_RS04235	COG0069	glutamate synthase activity
JC281_RS04240	COG4129	membrane
JC281_RS04245	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JC281_RS04250	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JC281_RS04260	COG0735	belongs to the Fur family
JC281_RS04485	COG0765	amino acid transport
JC281_RS04490	COG1126	abc transporter atp-binding protein
JC281_RS04495	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JC281_RS04505	COG0363	glucosamine-6-phosphate deaminase activity
JC281_RS04520	COG0114	fumarate hydratase activity
JC281_RS04525	COG0248	Ppx GppA phosphatase
JC281_RS04530	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
JC281_RS04535	COG0564	pseudouridine synthase activity
JC281_RS04540	COG4585	Histidine kinase
JC281_RS04540	COG2203	Gaf domain
JC281_RS04545	COG2197	response regulator
JC281_RS04550	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
JC281_RS04565	COG4399	Belongs to the UPF0754 family
JC281_RS04570	COG3679	Belongs to the UPF0342 family
JC281_RS04575	COG0420	3'-5' exonuclease activity
JC281_RS04585	COG3481	metal-dependent phosphohydrolase, HD sub domain
JC281_RS04590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JC281_RS04605	COG1846	Transcriptional regulator
JC281_RS04615	COG0537	adenosine 5'-monophosphoramidase activity
JC281_RS04620	COG1131	(ABC) transporter
JC281_RS04625	COG4473	ABC transporter
JC281_RS04630	COG3344	reverse transcriptase
JC281_RS04640	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JC281_RS04650	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
JC281_RS04655	COG3545	Serine hydrolase
JC281_RS04765	COG3623	hexulose-6-phosphate isomerase
JC281_RS04770	COG0235	Class ii aldolase
JC281_RS04790	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
JC281_RS04795	COG0494	nUDIX hydrolase
JC281_RS04800	COG1506	peptidase
JC281_RS04805	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
JC281_RS04810	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JC281_RS04820	COG0656	L-ascorbic acid biosynthetic process
JC281_RS04825	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JC281_RS04830	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JC281_RS04840	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JC281_RS04865	COG3266	domain, Protein
JC281_RS04865	COG5632	N-Acetylmuramoyl-L-alanine amidase
JC281_RS04865	COG4193	domain, Protein
JC281_RS04875	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JC281_RS04875	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JC281_RS04880	COG0307	riboflavin synthase, alpha
JC281_RS04885	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JC281_RS04885	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JC281_RS04890	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
JC281_RS04905	COG2267	carboxylic ester hydrolase activity
JC281_RS04910	COG0039	L-malate dehydrogenase activity
JC281_RS04920	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
JC281_RS04925	COG1242	4 iron, 4 sulfur cluster binding
JC281_RS04930	COG2814	Major facilitator Superfamily
JC281_RS04935	COG0495	leucyl-tRNA aminoacylation
JC281_RS04940	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JC281_RS04945	COG2081	HI0933 family
JC281_RS04950	COG2244	polysaccharide biosynthetic process
JC281_RS04955	COG1187	pseudouridine synthase activity
JC281_RS04965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JC281_RS04970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JC281_RS04975	COG0510	thiamine kinase activity
JC281_RS04980	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JC281_RS04985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JC281_RS04995	COG1363	Peptidase, m42
JC281_RS05000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JC281_RS05005	COG4848	Belongs to the UPF0354 family
JC281_RS05010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JC281_RS05015	COG1674	ftsk spoiiie
JC281_RS05020	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JC281_RS05025	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
JC281_RS05035	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
JC281_RS05035	COG1605	Chorismate mutase
JC281_RS05040	COG1609	Transcriptional regulator
JC281_RS05050	COG0454	-acetyltransferase
JC281_RS05055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JC281_RS05060	COG2759	Belongs to the formate--tetrahydrofolate ligase family
JC281_RS05065	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
JC281_RS05075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JC281_RS05080	COG0204	Acyl-transferase
JC281_RS05090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JC281_RS05095	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JC281_RS05100	COG1764	response to oxidative stress
JC281_RS05150	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JC281_RS05155	COG1956	GAF domain-containing protein
JC281_RS05160	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
JC281_RS05165	COG1104	cysteine desulfurase activity
JC281_RS05170	COG0301	tRNA thio-modification
JC281_RS05180	COG0616	signal peptide processing
JC281_RS05185	COG1714	RDD family
JC281_RS05190	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
JC281_RS05195	COG0827	DNA restriction-modification system
JC281_RS05200	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JC281_RS05205	COG0589	response to stress
JC281_RS05210	COG0686	Belongs to the AlaDH PNT family
JC281_RS05220	COG0006	proline dipeptidase activity
JC281_RS05225	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
JC281_RS05235	COG4109	DRTGG domain
JC281_RS05240	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
JC281_RS05245	COG0587	DNA-directed DNA polymerase activity
JC281_RS05250	COG0281	malic enzyme
JC281_RS05255	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JC281_RS05260	COG0825	malonyl-CoA metabolic process
JC281_RS05265	COG0205	6-phosphofructokinase activity
JC281_RS05270	COG0469	pyruvate kinase activity
JC281_RS05275	COG0372	Belongs to the citrate synthase family
JC281_RS05280	COG0538	isocitrate dehydrogenase activity
JC281_RS05285	COG0745	RESPONSE REGULATOR receiver
JC281_RS05290	COG5002	protein histidine kinase activity
JC281_RS05295	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JC281_RS05295	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JC281_RS05305	COG0237	dephospho-CoA kinase activity
JC281_RS05320	COG3611	Membrane attachment protein
JC281_RS05325	COG1484	DNA-dependent DNA replication
JC281_RS05335	COG0833	amino acid
JC281_RS05345	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JC281_RS05350	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JC281_RS05355	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
JC281_RS05370	COG0544	peptidyl-prolyl cis-trans isomerase activity
JC281_RS05380	COG0218	Necessary for normal cell division and for the maintenance of normal septation
JC281_RS05385	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JC281_RS05395	COG0181	hydroxymethylbilane synthase activity
JC281_RS05410	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JC281_RS05420	COG2818	Glycosylase
JC281_RS05425	COG0525	valine-tRNA ligase activity
JC281_RS05430	COG0285	dihydrofolate synthase activity
JC281_RS05440	COG2003	Belongs to the UPF0758 family
JC281_RS05480	COG2868	ribosomal protein
JC281_RS05490	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JC281_RS05500	COG0632	four-way junction helicase activity
JC281_RS05510	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
JC281_RS05520	COG1862	Preprotein translocase
JC281_RS05525	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JC281_RS05525	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JC281_RS05530	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
JC281_RS05530	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JC281_RS05535	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JC281_RS05545	COG1490	D-aminoacyl-tRNA deacylase activity
JC281_RS05550	COG0860	N-Acetylmuramoyl-L-alanine amidase
JC281_RS05560	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JC281_RS05570	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JC281_RS05575	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JC281_RS05580	COG1959	2 iron, 2 sulfur cluster binding
JC281_RS05595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JC281_RS05600	COG1104	cysteine desulfurase activity
JC281_RS05605	COG0482	sulfurtransferase activity
JC281_RS05615	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JC281_RS05620	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JC281_RS05625	COG4472	Bacterial protein of unknown function (DUF965)
JC281_RS05630	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JC281_RS05635	COG3906	Belongs to the UPF0473 family
JC281_RS05640	COG4122	O-methyltransferase activity
JC281_RS05645	COG0826	peptidase U32
JC281_RS05650	COG0826	peptidase U32
JC281_RS05655	COG0572	uridine kinase
JC281_RS05665	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JC281_RS05670	COG1984	allophanate hydrolase subunit 2
JC281_RS05675	COG0511	ligase activity, forming carbon-carbon bonds
JC281_RS05680	COG0439	Biotin carboxylase
JC281_RS05685	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
JC281_RS05690	COG1914	H( )-stimulated, divalent metal cation uptake system
JC281_RS05695	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JC281_RS05700	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
JC281_RS05705	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
JC281_RS05710	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JC281_RS05715	COG1534	Rna-binding protein
JC281_RS05725	COG1713	HD superfamily hydrolase involved in NAD metabolism
JC281_RS05730	COG0799	negative regulation of ribosome biogenesis
JC281_RS05735	COG2226	methyltransferase
JC281_RS05740	COG1555	photosystem II stabilization
JC281_RS05740	COG1596	polysaccharide export
JC281_RS05745	COG2131	deaminase
JC281_RS05750	COG0658	competence protein
JC281_RS05750	COG2333	competence protein COMEC
JC281_RS05755	COG1466	dna polymerase III delta subunit
JC281_RS05760	COG0268	Binds directly to 16S ribosomal RNA
JC281_RS05770	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JC281_RS05785	COG0443	Heat shock 70 kDa protein
JC281_RS05790	COG0484	heat shock protein binding
JC281_RS05795	COG2264	protein methyltransferase activity
JC281_RS05800	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JC281_RS05805	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JC281_RS05820	COG1030	water channel activity
JC281_RS05825	COG4864	UPF0365 protein
JC281_RS05835	COG1702	phosphate starvation-inducible protein PhoH
JC281_RS05845	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JC281_RS05855	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JC281_RS05860	COG1381	Involved in DNA repair and RecF pathway recombination
JC281_RS05865	COG0423	glycine-tRNA ligase activity
JC281_RS05870	COG0517	IMP dehydrogenase activity
JC281_RS05875	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JC281_RS05880	COG0358	DNA primase activity
JC281_RS05885	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JC281_RS05890	COG2384	SAM-dependent methyltransferase
JC281_RS05895	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JC281_RS05900	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JC281_RS05905	COG0513	Belongs to the DEAD box helicase family
JC281_RS05910	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
JC281_RS05915	COG1121	(ABC) transporter
JC281_RS05920	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JC281_RS05925	COG0735	belongs to the Fur family
JC281_RS05930	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JC281_RS05940	COG0768	penicillin binding
JC281_RS05945	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JC281_RS05950	COG0573	inorganic phosphate transmembrane transporter activity
JC281_RS05955	COG0581	inorganic phosphate transmembrane transporter activity
JC281_RS05960	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JC281_RS05965	COG0704	Plays a role in the regulation of phosphate uptake
JC281_RS05975	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JC281_RS05980	COG0705	Rhomboid family
JC281_RS05980	COG0457	Tetratricopeptide repeat
JC281_RS05985	COG4483	Protein conserved in bacteria
JC281_RS05990	COG1940	carbohydrate kinase activity
JC281_RS05995	COG0011	TIGRFAM Protein of
JC281_RS06000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JC281_RS06010	COG0582	viral genome integration into host DNA
JC281_RS06175	COG0740	serine-type endopeptidase activity
JC281_RS06265	COG4824	toxin secretion phage lysis holin
JC281_RS06300	COG3969	phosphoadenosine phosphosulfate
JC281_RS06305	COG1475	DNA binding
JC281_RS06340	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JC281_RS06345	COG0404	The glycine cleavage system catalyzes the degradation of glycine
JC281_RS06355	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JC281_RS06360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JC281_RS06365	COG0095	Lipoate-protein ligase
JC281_RS06380	COG0006	proline dipeptidase activity
JC281_RS06385	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JC281_RS06390	COG0511	ligase activity, forming carbon-carbon bonds
JC281_RS06395	COG0439	Biotin carboxylase
JC281_RS06400	COG1302	Protein conserved in bacteria
JC281_RS06410	COG1570	exodeoxyribonuclease VII activity
JC281_RS06415	COG1722	exodeoxyribonuclease VII activity
JC281_RS06420	COG0142	geranyltranstransferase activity
JC281_RS06425	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JC281_RS06430	COG1438	arginine binding
JC281_RS06435	COG0497	DNA recombination
JC281_RS06440	COG0280	phosphate acetyltransferase
JC281_RS06445	COG3426	butyrate kinase activity
JC281_RS06450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JC281_RS06455	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
JC281_RS06460	COG0022	dehydrogenase e1 component
JC281_RS06465	COG0508	dehydrogenase complex catalyzes the overall conversion of
JC281_RS06475	COG4129	membrane
JC281_RS06485	COG2195	Cleaves the N-terminal amino acid of tripeptides
JC281_RS06515	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
JC281_RS06520	COG1234	tRNA 3'-trailer cleavage
JC281_RS06525	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JC281_RS06535	COG0667	Aldo Keto reductase
JC281_RS06540	COG0494	nUDIX hydrolase
JC281_RS06545	COG0735	belongs to the Fur family
JC281_RS06560	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
JC281_RS06565	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
JC281_RS06570	COG1187	pseudouridine synthase activity
JC281_RS06575	COG0745	RESPONSE REGULATOR receiver
JC281_RS06590	COG1141	Ferredoxin
JC281_RS06600	COG0514	ATP-dependent DNA helicase (RecQ)
JC281_RS06610	COG0492	ferredoxin-NADP+ reductase activity
JC281_RS06615	COG0252	asparaginase activity
JC281_RS06625	COG0539	negative regulation of cytoplasmic translation
JC281_RS06630	COG1160	GTP binding
JC281_RS06635	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JC281_RS06655	COG0142	geranyltranstransferase activity
JC281_RS06660	COG0105	UTP biosynthetic process
JC281_RS06670	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JC281_RS06680	COG0457	Tetratricopeptide repeat
JC281_RS06685	COG5582	Belongs to the UPF0302 family
JC281_RS06690	COG4347	Protein of unknown function (DUF1405)
JC281_RS06700	COG1694	Mazg nucleotide pyrophosphohydrolase
JC281_RS06705	COG0438	transferase activity, transferring glycosyl groups
JC281_RS06710	COG0617	tRNA 3'-terminal CCA addition
JC281_RS06725	COG0017	Asparaginyl-tRNA synthetase
JC281_RS06730	COG3935	DnaD domain protein
JC281_RS06735	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JC281_RS06745	COG4499	WXG100 protein secretion system (Wss), protein YukC
JC281_RS06745	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JC281_RS06760	COG4474	Belongs to the UPF0398 family
JC281_RS06765	COG3599	regulation of cell shape
JC281_RS06775	COG0116	Belongs to the methyltransferase superfamily
JC281_RS06780	COG2962	Rard protein
JC281_RS06785	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
JC281_RS06790	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JC281_RS06800	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
JC281_RS06810	COG1413	lyase activity
JC281_RS06845	COG2190	(PTS) system
JC281_RS06855	COG0793	Belongs to the peptidase S41A family
JC281_RS06870	COG0671	phosphoesterase, PA-phosphatase related
JC281_RS06880	COG5002	protein histidine kinase activity
JC281_RS06885	COG0567	Dehydrogenase, E1 component
JC281_RS06935	COG0714	Associated with various cellular activities
JC281_RS06940	COG4548	von Willebrand factor, type A
JC281_RS06945	COG1114	Component of the transport system for branched-chain amino acids
JC281_RS06950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JC281_RS06960	COG3853	Toxic anion resistance protein (TelA)
JC281_RS06980	COG1278	Cold shock
JC281_RS07000	COG1473	amidohydrolase
JC281_RS07005	COG2171	N-acyltransferase activity
JC281_RS07010	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JC281_RS07015	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JC281_RS07020	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JC281_RS07025	COG0488	(ABC) transporter
JC281_RS07030	COG2996	Protein conserved in bacteria
JC281_RS07060	COG1363	Peptidase, m42
JC281_RS07065	COG0287	Prephenate dehydrogenase
JC281_RS07070	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JC281_RS07080	COG1942	4-Oxalocrotonate Tautomerase
JC281_RS07100	COG0628	permease
JC281_RS07110	COG3711	transcriptional antiterminator
JC281_RS07115	COG1115	amino acid carrier protein
JC281_RS07120	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JC281_RS07130	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
JC281_RS07135	COG4841	protein insertion into membrane
JC281_RS07140	COG0824	Thioesterase
JC281_RS07150	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JC281_RS07155	COG1970	mechanosensitive ion channel activity
JC281_RS07160	COG0419	ATPase involved in DNA repair
JC281_RS07165	COG0420	3'-5' exonuclease activity
JC281_RS07170	COG4846	Membrane protein involved in cytochrome C biogenesis
JC281_RS07175	COG3763	UPF0154 protein
JC281_RS07185	COG4224	UPF0291 protein
JC281_RS07195	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JC281_RS07205	COG0516	GMP reductase activity
JC281_RS07210	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JC281_RS07220	COG0833	amino acid
JC281_RS07235	COG0083	homoserine kinase activity
JC281_RS07240	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JC281_RS07245	COG0460	homoserine dehydrogenase
JC281_RS07250	COG0527	aspartate kinase activity
JC281_RS07270	COG1525	nuclease
JC281_RS07300	COG0584	glycerophosphoryl diester phosphodiesterase
JC281_RS07320	COG0789	Transcriptional regulator
JC281_RS07325	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
JC281_RS07330	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JC281_RS07335	COG0386	Belongs to the glutathione peroxidase family
JC281_RS07340	COG2267	carboxylic ester hydrolase activity
JC281_RS07345	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JC281_RS07350	COG1923	regulation of RNA biosynthetic process
JC281_RS07355	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JC281_RS07365	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JC281_RS07370	COG1619	proteins homologs of microcin C7 resistance protein MccF
JC281_RS07375	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
JC281_RS07380	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
JC281_RS07400	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JC281_RS07410	COG1013	pyruvate-flavodoxin oxidoreductase activity
JC281_RS07415	COG0674	pyruvate-flavodoxin oxidoreductase activity
JC281_RS07415	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JC281_RS07420	COG1692	metallophosphoesterase
JC281_RS07440	COG1418	mRNA catabolic process
JC281_RS07445	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JC281_RS07450	COG1058	Belongs to the CinA family
JC281_RS07450	COG1546	Belongs to the CinA family
JC281_RS07470	COG0300	oxidoreductase activity
JC281_RS07475	COG0612	Peptidase, M16
JC281_RS07480	COG0612	Peptidase, M16
JC281_RS07485	COG2188	Transcriptional regulator
JC281_RS07500	COG1185	polyribonucleotide nucleotidyltransferase activity
JC281_RS07510	COG0196	riboflavin kinase activity
JC281_RS07515	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JC281_RS07520	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JC281_RS07530	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JC281_RS07535	COG1358	cellular component organization or biogenesis
JC281_RS07540	COG2740	Nucleic-acid-binding protein implicated in transcription termination
JC281_RS07545	COG0195	Participates in both transcription termination and antitermination
JC281_RS07550	COG0779	Required for maturation of 30S ribosomal subunits
JC281_RS07560	COG0442	prolyl-tRNA aminoacylation
JC281_RS07570	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
JC281_RS07575	COG4589	Belongs to the CDS family
JC281_RS07580	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JC281_RS07585	COG0233	cytoplasmic translational termination
JC281_RS07590	COG0528	UMP kinase activity
JC281_RS07595	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JC281_RS07600	COG0052	Belongs to the universal ribosomal protein uS2 family
JC281_RS07605	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
JC281_RS07610	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
JC281_RS07615	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
JC281_RS07620	COG4974	Belongs to the 'phage' integrase family
JC281_RS07625	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
JC281_RS07630	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JC281_RS07635	COG0758	DNA mediated transformation
JC281_RS07645	COG0045	succinate-CoA ligase (ADP-forming) activity
JC281_RS07655	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JC281_RS07670	COG4485	Bacterial membrane protein, YfhO
JC281_RS07710	COG0336	Belongs to the RNA methyltransferase TrmD family
JC281_RS07715	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JC281_RS07720	COG0228	four-way junction DNA binding
JC281_RS07735	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JC281_RS07740	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
JC281_RS07745	COG0552	protein localization to endoplasmic reticulum
JC281_RS07750	COG1196	nuclear chromosome segregation
JC281_RS07755	COG0571	ribonuclease III activity
JC281_RS07760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JC281_RS07775	COG0416	fatty acid biosynthetic process
JC281_RS07780	COG1349	DNA-binding transcription factor activity
JC281_RS07790	COG1760	l-serine dehydratase
JC281_RS07795	COG1760	l-serine dehydratase
JC281_RS07810	COG1302	Protein conserved in bacteria
JC281_RS07825	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JC281_RS07830	COG1162	GTPase activity
JC281_RS07840	COG2124	cytochrome p450
JC281_RS07855	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JC281_RS07860	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JC281_RS07860	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JC281_RS07865	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JC281_RS07870	COG0242	peptide deformylase activity
JC281_RS07875	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JC281_RS07880	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JC281_RS07885	COG1758	RNA polymerase activity
JC281_RS07890	COG0194	GDP metabolic process
JC281_RS07905	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JC281_RS07910	COG0284	orotidine-5'-phosphate decarboxylase activity
JC281_RS07915	COG0167	dihydroorotate dehydrogenase activity
JC281_RS07925	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JC281_RS07930	COG0505	Belongs to the CarA family
JC281_RS07950	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
JC281_RS07955	COG0564	pseudouridine synthase activity
JC281_RS07960	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JC281_RS07965	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JC281_RS07970	COG3599	regulation of cell shape
JC281_RS07985	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JC281_RS07990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JC281_RS08000	COG4975	Glucose uptake
JC281_RS08005	COG1869	D-ribose catabolic process
JC281_RS08010	COG0762	integral membrane protein
JC281_RS08015	COG1799	cell septum assembly
JC281_RS08020	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JC281_RS08030	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JC281_RS08035	COG0849	cell division
JC281_RS08045	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JC281_RS08055	COG0768	penicillin binding
JC281_RS08060	COG4839	cell division protein FtsL
JC281_RS08065	COG0275	rRNA processing
JC281_RS08070	COG2001	Belongs to the MraZ family
JC281_RS08075	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
JC281_RS08080	COG0454	-acetyltransferase
JC281_RS08085	COG1011	Hydrolase
JC281_RS08100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JC281_RS08160	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JC281_RS08165	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JC281_RS08170	COG1053	succinate dehydrogenase
JC281_RS08175	COG2009	succinate dehydrogenase
JC281_RS08180	COG0322	excinuclease ABC activity
JC281_RS08185	COG3118	belongs to the thioredoxin family
JC281_RS08190	COG1193	negative regulation of DNA recombination
JC281_RS08195	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JC281_RS08195	COG1796	DNA polymerase
JC281_RS08210	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JC281_RS08225	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JC281_RS08230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JC281_RS08235	COG0333	Belongs to the bacterial ribosomal protein bL32 family
JC281_RS08255	COG0742	ribosomal rna small subunit methyltransferase
JC281_RS08265	COG4471	UPF0298 protein
JC281_RS08270	COG0584	glycerophosphoryl diester phosphodiesterase
JC281_RS08275	COG3679	Belongs to the UPF0342 family
JC281_RS08305	COG3344	reverse transcriptase
JC281_RS08310	COG0772	Belongs to the SEDS family
JC281_RS08315	COG4838	Belongs to the UPF0358 family
JC281_RS08320	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
JC281_RS08325	COG4896	Protein conserved in bacteria
JC281_RS08330	COG1902	pentaerythritol trinitrate reductase activity
JC281_RS08335	COG1217	gtp-binding protein TYPA
JC281_RS08345	COG0483	inositol monophosphate 1-phosphatase activity
JC281_RS08350	COG4493	Belongs to the UPF0637 family
JC281_RS08370	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
JC281_RS08375	COG1177	transmembrane transport
JC281_RS08385	COG3842	ATPase activity
JC281_RS08395	COG4476	Belongs to the UPF0223 family
JC281_RS08435	COG5503	Protein of unknown function (DUF1447)
JC281_RS08440	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
JC281_RS08445	COG0492	ferredoxin-NADP+ reductase activity
JC281_RS08475	COG0569	domain protein
JC281_RS08480	COG1294	oxidase, subunit
JC281_RS08485	COG1271	oxidase subunit
JC281_RS08490	COG1393	Belongs to the ArsC family
JC281_RS08495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JC281_RS08500	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JC281_RS08510	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JC281_RS08530	COG4172	Belongs to the ABC transporter superfamily
JC281_RS08540	COG0151	Belongs to the GarS family
JC281_RS08545	COG0138	bifunctional purine biosynthesis protein purh
JC281_RS08555	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JC281_RS08560	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
JC281_RS08570	COG0047	phosphoribosylformylglycinamidine synthase activity
JC281_RS08575	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JC281_RS08580	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JC281_RS08585	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
JC281_RS08590	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JC281_RS08595	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JC281_RS08600	COG1017	nitric oxide dioxygenase activity
JC281_RS08600	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JC281_RS08610	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JC281_RS08620	COG1845	cytochrome c oxidase, subunit III
JC281_RS08625	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
JC281_RS08635	COG3212	peptidase
JC281_RS08650	COG1134	teichoic acid transport
JC281_RS08660	COG1682	transport, permease protein
JC281_RS08670	COG1215	transferase activity, transferring glycosyl groups
JC281_RS08680	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
JC281_RS08685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JC281_RS08690	COG1316	TRANSCRIPTIONal
JC281_RS08715	COG3594	Acyltransferase
JC281_RS08720	COG0436	Aminotransferase
JC281_RS08725	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
JC281_RS08735	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
JC281_RS08740	COG1169	isochorismate synthase
JC281_RS08745	COG1575	Belongs to the MenA family. Type 1 subfamily
JC281_RS08750	COG0390	transport system, permease component
JC281_RS08755	COG4619	ABC transporter
JC281_RS08775	COG4873	Protein conserved in bacteria
JC281_RS08850	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
JC281_RS08850	COG4932	domain protein
JC281_RS08850	COG3266	domain, Protein
JC281_RS08855	COG0737	Belongs to the 5'-nucleotidase family
JC281_RS08865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JC281_RS08870	COG1696	Membrane protein involved in D-alanine export
JC281_RS08880	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
JC281_RS08885	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JC281_RS08890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JC281_RS08895	COG0861	Integral membrane protein TerC family
JC281_RS08900	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
JC281_RS08910	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JC281_RS08915	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JC281_RS08920	COG2814	Major facilitator Superfamily
JC281_RS08930	COG3715	PTS system
JC281_RS08935	COG3716	PTS system mannose fructose sorbose family IID component
JC281_RS08940	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
JC281_RS08945	COG2382	esterase
JC281_RS08950	COG1115	amino acid carrier protein
JC281_RS08955	COG0628	permease
JC281_RS08960	COG4409	exo-alpha-(2->6)-sialidase activity
JC281_RS08965	COG2211	Major facilitator Superfamily
JC281_RS08970	COG0673	inositol 2-dehydrogenase activity
JC281_RS08980	COG0569	domain protein
JC281_RS08980	COG0475	glutathione-regulated potassium exporter activity
JC281_RS08985	COG2239	Acts as a magnesium transporter
JC281_RS08990	COG0564	pseudouridine synthase activity
JC281_RS09000	COG2357	RelA SpoT domain protein
JC281_RS09015	COG2346	COG2346, Truncated hemoglobins
JC281_RS09020	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
JC281_RS09030	COG1164	Oligoendopeptidase f
JC281_RS09045	COG1393	Belongs to the ArsC family
JC281_RS09050	COG0180	Tryptophanyl-tRNA synthetase
JC281_RS09055	COG4166	transmembrane transport
JC281_RS09060	COG4608	Belongs to the ABC transporter superfamily
JC281_RS09065	COG0444	Belongs to the ABC transporter superfamily
JC281_RS09070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JC281_RS09075	COG0601	transmembrane transport
JC281_RS09100	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
JC281_RS09120	COG0561	phosphatase activity
JC281_RS09125	COG0446	pyridine nucleotide-disulphide oxidoreductase
JC281_RS09130	COG3344	reverse transcriptase
JC281_RS09145	COG0179	Fumarylacetoacetate (FAA) hydrolase
JC281_RS09150	COG1074	ATP-dependent DNA helicase activity
JC281_RS09155	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
JC281_RS09170	COG0166	Belongs to the GPI family
JC281_RS09175	COG0137	argininosuccinate synthase activity
JC281_RS09185	COG0584	glycerophosphoryl diester phosphodiesterase
JC281_RS09200	COG1012	belongs to the aldehyde dehydrogenase family
JC281_RS09205	COG1098	S1 RNA binding domain
JC281_RS09215	COG1278	Cold shock
JC281_RS09235	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JC281_RS09245	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JC281_RS09245	COG2111	Na H antiporter
JC281_RS09250	COG2111	Na H antiporter
JC281_RS09255	COG1006	Multisubunit Na H antiporter MnhC subunit
JC281_RS09260	COG0651	ATP synthesis coupled electron transport
JC281_RS09265	COG1863	multisubunit Na H antiporter MnhE subunit
JC281_RS09270	COG2212	antiporter activity
JC281_RS09275	COG1320	monovalent cation:proton antiporter activity
JC281_RS09285	COG2056	Na+-H+ antiporter family
JC281_RS09290	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JC281_RS09295	COG1252	NADH dehydrogenase
JC281_RS09300	COG0316	Belongs to the HesB IscA family
JC281_RS09305	COG4844	belongs to the
JC281_RS09310	COG1252	NADH dehydrogenase
JC281_RS09315	COG4837	Protein of unknown function (DUF1462)
JC281_RS09320	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
JC281_RS09325	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JC281_RS09330	COG0647	UMP catabolic process
JC281_RS09335	COG2445	Protein of unknown function DUF86
JC281_RS09345	COG4470	Protein conserved in bacteria
JC281_RS09350	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JC281_RS09355	COG0737	Belongs to the 5'-nucleotidase family
JC281_RS09360	COG0730	response to heat
JC281_RS09365	COG1801	Protein of unknown function DUF72
JC281_RS09380	COG1253	flavin adenine dinucleotide binding
JC281_RS09390	COG0719	Fe-S assembly protein
JC281_RS09395	COG0822	iron-sulfur transferase activity
JC281_RS09405	COG0719	Fe-S assembly protein
JC281_RS09410	COG0396	ATPase activity
JC281_RS09420	COG1464	Belongs to the NlpA lipoprotein family
JC281_RS09425	COG1464	Belongs to the NlpA lipoprotein family
JC281_RS09430	COG2011	ABC-type metal ion transport system permease component
JC281_RS09435	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JC281_RS09440	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JC281_RS09445	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
JC281_RS09455	COG1393	Belongs to the ArsC family
JC281_RS09460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JC281_RS09470	COG0710	3-dehydroquinate dehydratase activity
JC281_RS09480	COG1764	response to oxidative stress
JC281_RS09495	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JC281_RS09515	COG0346	lactoylglutathione lyase activity
JC281_RS09545	COG0557	exoribonuclease II activity
JC281_RS09550	COG1647	Serine aminopeptidase, S33
JC281_RS09555	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JC281_RS09565	COG0148	phosphopyruvate hydratase activity
JC281_RS09570	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
JC281_RS09600	COG1090	epimerase
JC281_RS09610	COG0740	serine-type endopeptidase activity
JC281_RS09620	COG1481	regulation of sporulation
JC281_RS09625	COG0391	Required for morphogenesis under gluconeogenic growth conditions
JC281_RS09630	COG1660	Displays ATPase and GTPase activities
JC281_RS09645	COG0110	maltose O-acetyltransferase activity
JC281_RS09650	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JC281_RS09655	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
JC281_RS09690	COG0653	protein targeting
JC281_RS09705	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
JC281_RS09715	COG1739	Uncharacterized protein family UPF0029
JC281_RS09720	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JC281_RS09740	COG2195	Cleaves the N-terminal amino acid of tripeptides
JC281_RS09750	COG1929	Belongs to the glycerate kinase type-1 family
JC281_RS09755	COG3118	belongs to the thioredoxin family
JC281_RS09770	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JC281_RS09780	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JC281_RS09785	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JC281_RS09840	COG2801	Transposase and inactivated derivatives
JC281_RS09855	COG3104	oligopeptide transport
JC281_RS09860	COG3104	oligopeptide transport
JC281_RS09875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JC281_RS09880	COG1174	glycine betaine transport
JC281_RS09885	COG0517	IMP dehydrogenase activity
JC281_RS09885	COG1125	glycine betaine transport
JC281_RS09890	COG0514	ATP-dependent DNA helicase (RecQ)
JC281_RS09895	COG0488	(ABC) transporter
JC281_RS09905	COG2274	protein secretion by the type I secretion system
JC281_RS09910	COG2274	protein secretion by the type I secretion system
JC281_RS09920	COG0463	Glycosyl transferase, family 2
JC281_RS09925	COG1368	sulfuric ester hydrolase activity
JC281_RS09935	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JC281_RS09955	COG0512	Glutamine amidotransferase of anthranilate synthase
JC281_RS09965	COG0720	synthase
JC281_RS09970	COG0602	queuosine metabolic process
JC281_RS09985	COG0463	Glycosyl transferase, family 2
JC281_RS09990	COG1253	flavin adenine dinucleotide binding
JC281_RS09995	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JC281_RS09995	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JC281_RS09995	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JC281_RS10000	COG1105	Belongs to the carbohydrate kinase PfkB family
JC281_RS10005	COG1349	DNA-binding transcription factor activity
JC281_RS10025	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JC281_RS10030	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JC281_RS10050	COG0039	L-malate dehydrogenase activity
JC281_RS10070	COG4989	oxidoreductase activity
JC281_RS10075	COG0523	cobalamin synthesis protein
JC281_RS10085	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
JC281_RS10090	COG4988	ABC transporter
JC281_RS10095	COG1968	undecaprenyl-diphosphatase activity
JC281_RS10105	COG1671	Belongs to the UPF0178 family
JC281_RS10110	COG1611	Belongs to the LOG family
JC281_RS10140	COG2839	Protein conserved in bacteria
JC281_RS10145	COG2814	Major facilitator Superfamily
JC281_RS10150	COG0583	DNA-binding transcription factor activity
JC281_RS10165	COG0217	transcriptional regulatory protein
JC281_RS10170	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JC281_RS10175	COG2022	thiamine diphosphate biosynthetic process
JC281_RS10185	COG0352	thiamine-phosphate diphosphorylase activity
JC281_RS10195	COG3942	CHAP domain
JC281_RS10195	COG1388	LysM domain
JC281_RS10200	COG0306	phosphate transporter
JC281_RS10205	COG1392	Phosphate transport regulator
JC281_RS10210	COG0577	efflux transmembrane transporter activity
JC281_RS10215	COG1136	(ABC) transporter
JC281_RS10225	COG0745	RESPONSE REGULATOR receiver
JC281_RS10230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JC281_RS10235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JC281_RS10245	COG3949	Membrane
JC281_RS10250	COG0477	Major facilitator Superfamily
JC281_RS10260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JC281_RS10265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JC281_RS10270	COG1120	ATPase activity
JC281_RS10275	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JC281_RS10280	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JC281_RS10300	COG1132	(ABC) transporter
JC281_RS10305	COG1686	Belongs to the peptidase S11 family
JC281_RS10315	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
JC281_RS10320	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JC281_RS10325	COG1682	transport, permease protein
JC281_RS10335	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
JC281_RS10340	COG0110	maltose O-acetyltransferase activity
JC281_RS10350	COG1475	DNA binding
JC281_RS10355	COG0019	diaminopimelate decarboxylase activity
JC281_RS10365	COG4264	IucA IucC family
JC281_RS10370	COG4264	IucA IucC family
JC281_RS10375	COG2814	Major facilitator Superfamily
JC281_RS10380	COG4264	IucA IucC family
JC281_RS10385	COG2423	ornithine cyclodeaminase activity
JC281_RS10395	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JC281_RS10400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JC281_RS10405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JC281_RS10415	COG1121	(ABC) transporter
JC281_RS10420	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JC281_RS10425	COG0803	Belongs to the bacterial solute-binding protein 9 family
JC281_RS10430	COG1320	monovalent cation:proton antiporter activity
JC281_RS10435	COG2212	antiporter activity
JC281_RS10440	COG1863	multisubunit Na H antiporter MnhE subunit
JC281_RS10450	COG1006	Multisubunit Na H antiporter MnhC subunit
JC281_RS10455	COG2111	Na H antiporter
JC281_RS10460	COG2111	Na H antiporter
JC281_RS10460	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JC281_RS10510	COG0546	phosphoglycolate phosphatase activity
JC281_RS10515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JC281_RS10520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JC281_RS10525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JC281_RS10530	COG0805	protein transport
JC281_RS10535	COG0018	arginyl-trna synthetase
JC281_RS10550	COG1078	dGTPase activity
JC281_RS10560	COG4844	belongs to the
JC281_RS10630	COG0471	metal ion transport
JC281_RS10655	COG0280	phosphate acetyltransferase
JC281_RS10660	COG0095	Lipoate-protein ligase
JC281_RS10685	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JC281_RS10690	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
JC281_RS10700	COG2814	Major facilitator Superfamily
JC281_RS10705	COG1566	PFAM secretion protein HlyD family protein
JC281_RS10715	COG2311	Membrane
JC281_RS10750	COG2363	Small membrane protein
JC281_RS10780	COG0183	Belongs to the thiolase family
JC281_RS10785	COG0318	PFAM AMP-dependent synthetase and ligase
JC281_RS10790	COG0588	phosphoglycerate mutase activity
JC281_RS10815	COG1131	(ABC) transporter
JC281_RS10820	COG1994	Peptidase M50
JC281_RS10825	COG0535	radical SAM domain protein
JC281_RS10850	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JC281_RS10855	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JC281_RS10865	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
JC281_RS10880	COG2190	(PTS) system
JC281_RS10880	COG1263	PTS System
JC281_RS10880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JC281_RS10895	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JC281_RS10900	COG1469	GTP cyclohydrolase I activity
JC281_RS10905	COG0577	efflux transmembrane transporter activity
JC281_RS10905	COG1136	(ABC) transporter
JC281_RS10920	COG0561	phosphatase activity
JC281_RS10930	COG1428	Deoxynucleoside kinase
JC281_RS10935	COG1428	Deoxynucleoside kinase
JC281_RS10940	COG0546	phosphoglycolate phosphatase activity
JC281_RS10970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JC281_RS10980	COG1473	amidohydrolase
JC281_RS10985	COG3527	Alpha-acetolactate decarboxylase
JC281_RS10990	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JC281_RS10995	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JC281_RS11000	COG0049	tRNA binding
JC281_RS11005	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JC281_RS11015	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JC281_RS11020	COG0085	RNA polymerase activity
JC281_RS11025	COG2813	Specifically methylates the guanine in position
JC281_RS11035	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JC281_RS11040	COG0081	regulation of translation
JC281_RS11045	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JC281_RS11050	COG0250	Participates in transcription elongation, termination and antitermination
JC281_RS11055	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JC281_RS11060	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JC281_RS11080	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
JC281_RS11085	COG0215	cysteine-tRNA ligase activity
JC281_RS11090	COG1045	serine acetyltransferase
JC281_RS11095	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JC281_RS11105	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JC281_RS11110	COG4956	integral membrane protein (PIN domain superfamily)
JC281_RS11115	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JC281_RS11150	COG0542	response to heat
JC281_RS11155	COG3869	Catalyzes the specific phosphorylation of arginine residues in
JC281_RS11160	COG3880	PFAM UvrB UvrC protein
JC281_RS11170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JC281_RS11180	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
JC281_RS11185	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
JC281_RS11190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JC281_RS11195	COG1289	transmembrane transporter activity
JC281_RS11285	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JC281_RS11290	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JC281_RS11300	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JC281_RS11310	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
JC281_RS11315	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JC281_RS11330	COG1098	S1 RNA binding domain
JC281_RS11340	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
JC281_RS11345	COG3956	TIGRFAM MazG family protein
JC281_RS11350	COG2244	polysaccharide biosynthetic process
JC281_RS11355	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JC281_RS11360	COG0193	aminoacyl-tRNA hydrolase activity
JC281_RS11370	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JC281_RS11375	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JC281_RS11380	COG2088	sporulation resulting in formation of a cellular spore
JC281_RS11385	COG0251	oxidation-reduction process
JC281_RS11390	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JC281_RS11395	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JC281_RS11400	COG4466	Protein conserved in bacteria
JC281_RS11410	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
JC281_RS11415	COG0084	hydrolase, TatD family'
JC281_RS11425	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
JC281_RS11430	COG2827	Endonuclease containing a URI domain
JC281_RS11435	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
JC281_RS11440	COG4467	Involved in initiation control of chromosome replication
JC281_RS11445	COG1774	PSP1 C-terminal conserved region
JC281_RS11450	COG0470	DNA polymerase III
JC281_RS11455	COG3870	Protein conserved in bacteria
JC281_RS11460	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JC281_RS11465	COG1982	Orn Lys Arg decarboxylase major
JC281_RS11490	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JC281_RS11495	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JC281_RS11500	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JC281_RS11505	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JC281_RS11515	COG2188	Transcriptional regulator
JC281_RS11520	COG0366	Alpha amylase catalytic
JC281_RS11525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JC281_RS11525	COG1263	PTS System
JC281_RS11535	COG0493	'glutamate synthase
JC281_RS11540	COG0070	glutamate synthase
JC281_RS11540	COG0067	glutamate synthase
JC281_RS11540	COG0069	glutamate synthase activity
JC281_RS11545	COG0583	DNA-binding transcription factor activity
JC281_RS11560	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JC281_RS11575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JC281_RS11585	COG0535	radical SAM domain protein
JC281_RS11595	COG1131	(ABC) transporter
JC281_RS11640	COG0626	cystathionine gamma-synthase activity
JC281_RS11645	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JC281_RS11650	COG2272	Belongs to the type-B carboxylesterase lipase family
JC281_RS11655	COG0733	neurotransmitter:sodium symporter activity
JC281_RS11665	COG0745	RESPONSE REGULATOR receiver
JC281_RS11670	COG2205	protein histidine kinase activity
JC281_RS11680	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
JC281_RS11685	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
JC281_RS11710	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JC281_RS11715	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JC281_RS11715	COG0574	Belongs to the PEP-utilizing enzyme family
JC281_RS11735	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
JC281_RS11745	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
JC281_RS11755	COG1486	melibiose metabolic process
JC281_RS11760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JC281_RS11760	COG1263	PTS System
JC281_RS11780	COG2210	Belongs to the sulfur carrier protein TusA family
JC281_RS11785	COG1937	Protein conserved in bacteria
JC281_RS11790	COG0730	response to heat
JC281_RS11795	COG2814	Major facilitator Superfamily
JC281_RS11815	COG3682	Transcriptional regulator
JC281_RS11840	COG1124	(ABC) transporter
JC281_RS11845	COG0444	Belongs to the ABC transporter superfamily
JC281_RS11850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JC281_RS11855	COG0601	transmembrane transport
JC281_RS11885	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
JC281_RS11905	COG1525	nuclease
JC281_RS11925	COG3328	transposase activity
JC281_RS11955	COG1674	ftsk spoiiie
JC281_RS11960	COG2946	Replication initiation factor
JC281_RS12005	COG0741	lytic transglycosylase activity
JC281_RS12005	COG0791	NLP P60 protein
JC281_RS12055	COG0582	viral genome integration into host DNA
JC281_RS12060	COG0519	Catalyzes the synthesis of GMP from XMP
JC281_RS12060	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JC281_RS12065	COG0517	IMP dehydrogenase activity
JC281_RS12065	COG0516	GMP reductase activity
JC281_RS12070	COG2233	PERMEase
JC281_RS12075	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JC281_RS12090	COG5183	chlorophyll binding
JC281_RS12095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JC281_RS12100	COG1823	symporter activity
JC281_RS12105	COG1136	(ABC) transporter
JC281_RS12105	COG0577	efflux transmembrane transporter activity
JC281_RS12120	COG0778	Nitroreductase
JC281_RS12125	COG0450	alkyl hydroperoxide reductase
JC281_RS12140	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JC281_RS12150	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JC281_RS12155	COG2011	ABC-type metal ion transport system permease component
JC281_RS12160	COG1464	Belongs to the NlpA lipoprotein family
JC281_RS12165	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JC281_RS12170	COG0753	catalase activity
JC281_RS12180	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JC281_RS12190	COG0360	Binds together with S18 to 16S ribosomal RNA
JC281_RS12200	COG1668	transmembrane transport
JC281_RS12205	COG1131	(ABC) transporter
JC281_RS12210	COG0012	GTP binding
JC281_RS12215	COG4481	Protein conserved in bacteria
JC281_RS12220	COG0668	transmembrane transport
JC281_RS12225	COG1475	DNA binding
JC281_RS12230	COG0626	cystathionine gamma-synthase activity
JC281_RS12235	COG0626	cystathionine gamma-synthase activity
JC281_RS12240	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
JC281_RS12240	COG0646	methionine synthase
JC281_RS12245	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JC281_RS12250	COG0829	nickel cation binding
JC281_RS12260	COG0830	nickel cation binding
JC281_RS12265	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
JC281_RS12275	COG2388	GCN5-related N-acetyl-transferase
JC281_RS12280	COG1846	Transcriptional regulator
JC281_RS12285	COG0346	lactoylglutathione lyase activity
JC281_RS12290	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JC281_RS12295	COG0400	carboxylic ester hydrolase activity
JC281_RS12320	COG0357	Ribosomal RNA small subunit methyltransferase G
JC281_RS12325	COG0445	tRNA wobble uridine modification
JC281_RS12330	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
JC281_RS12335	COG0594	ribonuclease P activity