locus-tag	class	description
JC283_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JC283_RS00010	COG0592	DNA-directed DNA polymerase activity
JC283_RS00015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JC283_RS00015	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JC283_RS00020	COG2501	S4 domain
JC283_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JC283_RS00030	COG0187	DNA topoisomerase II activity
JC283_RS00040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JC283_RS00045	COG2986	histidine ammonia-lyase
JC283_RS00055	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
JC283_RS00065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
JC283_RS00070	COG4241	membrane
JC283_RS00075	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
JC283_RS00080	COG0359	binds to the 23S rRNA
JC283_RS00085	COG0305	Participates in initiation and elongation during chromosome replication
JC283_RS00090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JC283_RS00095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JC283_RS00115	COG0745	RESPONSE REGULATOR receiver
JC283_RS00120	COG5002	protein histidine kinase activity
JC283_RS00125	COG4863	YycH protein
JC283_RS00135	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
JC283_RS00155	COG0584	glycerophosphoryl diester phosphodiesterase
JC283_RS00160	COG2030	dehydratase
JC283_RS00185	COG1846	Transcriptional regulator
JC283_RS00185	COG1940	carbohydrate kinase activity
JC283_RS00195	COG2210	Belongs to the sulfur carrier protein TusA family
JC283_RS00200	COG1937	Protein conserved in bacteria
JC283_RS00205	COG0730	response to heat
JC283_RS00235	COG0785	Cytochrome C biogenesis protein
JC283_RS00250	COG3682	Transcriptional regulator
JC283_RS00255	COG1388	LysM domain
JC283_RS00260	COG5002	protein histidine kinase activity
JC283_RS00265	COG0745	RESPONSE REGULATOR receiver
JC283_RS00275	COG2132	Multicopper oxidase
JC283_RS00285	COG2311	Membrane
JC283_RS00305	COG0531	amino acid
JC283_RS00310	COG2217	Heavy metal translocating P-type atpase
JC283_RS00345	COG2188	Transcriptional regulator
JC283_RS00360	COG0415	Belongs to the DNA photolyase family
JC283_RS00375	COG0702	epimerase
JC283_RS00380	COG2130	NADP-dependent
JC283_RS00395	COG3177	Filamentation induced by cAMP protein fic
JC283_RS00400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JC283_RS00410	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
JC283_RS00415	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JC283_RS00435	COG2235	arginine
JC283_RS00450	COG2197	response regulator
JC283_RS00455	COG2203	Gaf domain
JC283_RS00455	COG4585	Histidine kinase
JC283_RS00460	COG0842	Transport permease protein
JC283_RS00465	COG1131	(ABC) transporter
JC283_RS00485	COG0431	NADPH-dependent FMN reductase
JC283_RS00490	COG3583	domain protein
JC283_RS00490	COG4932	domain protein
JC283_RS00490	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JC283_RS00510	COG1609	Transcriptional regulator
JC283_RS00520	COG0673	inositol 2-dehydrogenase activity
JC283_RS00530	COG0366	Alpha amylase catalytic
JC283_RS00540	COG3833	ABC-type maltose transport systems, permease component
JC283_RS00545	COG1175	transmembrane transport
JC283_RS00555	COG3842	ATPase activity
JC283_RS00560	COG0475	glutathione-regulated potassium exporter activity
JC283_RS00565	COG0490	domain, Protein
JC283_RS00575	COG0346	lactoylglutathione lyase activity
JC283_RS00585	COG0366	Alpha amylase catalytic
JC283_RS00590	COG2188	Transcriptional regulator
JC283_RS00595	COG2222	sugar isomerase
JC283_RS00600	COG1105	Belongs to the carbohydrate kinase PfkB family
JC283_RS00615	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
JC283_RS00615	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JC283_RS00620	COG3715	PTS system
JC283_RS00625	COG3716	PTS system mannose fructose sorbose family IID component
JC283_RS00635	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JC283_RS00655	COG3314	Sporulation integral membrane protein YlbJ
JC283_RS00675	COG1063	alcohol dehydrogenase
JC283_RS00690	COG1620	l-lactate permease
JC283_RS00695	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
JC283_RS00700	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
JC283_RS00705	COG0156	8-amino-7-oxononanoate synthase activity
JC283_RS00750	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
JC283_RS00765	COG0076	glutamate decarboxylase activity
JC283_RS00780	COG2318	DinB family
JC283_RS00785	COG0753	catalase activity
JC283_RS00795	COG0783	Belongs to the Dps family
JC283_RS00805	COG0436	Aminotransferase
JC283_RS00830	COG1136	(ABC) transporter
JC283_RS00840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JC283_RS00850	COG1755	Isoprenylcysteine carboxyl methyltransferase
JC283_RS00880	COG0579	oxidoreductase
JC283_RS00930	COG1073	alpha beta
JC283_RS00950	COG0438	transferase activity, transferring glycosyl groups
JC283_RS00955	COG0183	Belongs to the thiolase family
JC283_RS00970	COG0318	PFAM AMP-dependent synthetase and ligase
JC283_RS00980	COG2814	Major facilitator Superfamily
JC283_RS00990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JC283_RS01020	COG1609	Transcriptional regulator
JC283_RS01025	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JC283_RS01030	COG1869	D-ribose catabolic process
JC283_RS01055	COG3711	transcriptional antiterminator
JC283_RS01060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JC283_RS01070	COG3037	sugar-specific permease SgaT UlaA
JC283_RS01080	COG1328	CTP reductase activity
JC283_RS01100	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JC283_RS01105	COG1942	4-Oxalocrotonate Tautomerase
JC283_RS01115	COG3443	Belongs to the bacterial solute-binding protein 9 family
JC283_RS01115	COG0803	Belongs to the bacterial solute-binding protein 9 family
JC283_RS01140	COG4753	response regulator
JC283_RS01140	COG2207	Transcriptional regulator
JC283_RS01145	COG2972	Histidine kinase
JC283_RS01155	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JC283_RS01160	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
JC283_RS01165	COG0477	Major facilitator Superfamily
JC283_RS01170	COG2211	Major facilitator Superfamily
JC283_RS01175	COG3250	beta-galactosidase activity
JC283_RS01180	COG1957	nucleoside hydrolase
JC283_RS01215	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
JC283_RS01220	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
JC283_RS01225	COG2807	transmembrane transport
JC283_RS01230	COG1396	sequence-specific DNA binding
JC283_RS01245	COG1785	Belongs to the alkaline phosphatase family
JC283_RS01275	COG1914	H( )-stimulated, divalent metal cation uptake system
JC283_RS01285	COG1510	regulation of RNA biosynthetic process
JC283_RS01290	COG1012	belongs to the aldehyde dehydrogenase family
JC283_RS01295	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
JC283_RS01300	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JC283_RS01310	COG0156	8-amino-7-oxononanoate synthase activity
JC283_RS01325	COG0107	imidazoleglycerol-phosphate synthase activity
JC283_RS01330	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JC283_RS01345	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JC283_RS01350	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JC283_RS01355	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JC283_RS01360	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
JC283_RS01395	COG2376	Dihydroxyacetone kinase
JC283_RS01400	COG1461	Dihydroxyacetone kinase
JC283_RS01405	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
JC283_RS01410	COG2824	Alkylphosphonate utilization operon protein PhnA
JC283_RS01415	COG1012	belongs to the aldehyde dehydrogenase family
JC283_RS01430	COG0596	Alpha beta hydrolase
JC283_RS01435	COG0789	Transcriptional regulator
JC283_RS01440	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JC283_RS01440	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JC283_RS01440	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JC283_RS01450	COG1705	Flagellar rod assembly protein muramidase FlgJ
JC283_RS01450	COG3942	CHAP domain
JC283_RS01460	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JC283_RS01465	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JC283_RS01470	COG0747	negative chemotaxis
JC283_RS01495	COG0463	Glycosyl transferase, family 2
JC283_RS01495	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JC283_RS01510	COG0778	Nitroreductase
JC283_RS01515	COG3001	Fructosamine kinase
JC283_RS01540	COG1136	(ABC) transporter
JC283_RS01545	COG0577	efflux transmembrane transporter activity
JC283_RS01555	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
JC283_RS01565	COG4413	Urea transporter
JC283_RS01575	COG0832	Belongs to the urease beta subunit family
JC283_RS01580	COG0804	urea catabolic process
JC283_RS01585	COG0717	Belongs to the dCTP deaminase family
JC283_RS01590	COG0523	cobalamin synthesis protein
JC283_RS01600	COG1141	Ferredoxin
JC283_RS01625	COG0583	DNA-binding transcription factor activity
JC283_RS01635	COG1346	cytolysis
JC283_RS01650	COG1846	Transcriptional regulator
JC283_RS01655	COG0778	Nitroreductase
JC283_RS01660	COG2357	RelA SpoT domain protein
JC283_RS01700	COG1028	Short-chain dehydrogenase reductase Sdr
JC283_RS01715	COG3835	regulator
JC283_RS01720	COG2855	membrane
JC283_RS01725	COG3961	Belongs to the TPP enzyme family
JC283_RS01730	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
JC283_RS01735	COG0512	Glutamine amidotransferase of anthranilate synthase
JC283_RS01745	COG0134	indole-3-glycerol-phosphate synthase activity
JC283_RS01755	COG0133	tryptophan synthase activity
JC283_RS01760	COG0159	tryptophan synthase activity
JC283_RS01780	COG0277	FAD linked oxidase domain protein
JC283_RS01785	COG0247	lactate metabolic process
JC283_RS01790	COG1132	(ABC) transporter
JC283_RS01795	COG1132	(ABC) transporter
JC283_RS01800	COG0789	Transcriptional regulator
JC283_RS01810	COG3871	stress protein (general stress protein 26)
JC283_RS01815	COG1115	amino acid carrier protein
JC283_RS01820	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
JC283_RS01825	COG2814	Major facilitator Superfamily
JC283_RS01830	COG2271	Major facilitator Superfamily
JC283_RS01835	COG3764	Sortase (surface protein transpeptidase)
JC283_RS01840	COG1929	Belongs to the glycerate kinase type-1 family
JC283_RS01850	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
JC283_RS01870	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JC283_RS01875	COG0702	epimerase
JC283_RS01880	COG4166	transmembrane transport
JC283_RS01885	COG0444	Belongs to the ABC transporter superfamily
JC283_RS01890	COG4608	Belongs to the ABC transporter superfamily
JC283_RS01895	COG0601	transmembrane transport
JC283_RS01900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JC283_RS01905	COG4166	transmembrane transport
JC283_RS01910	COG0444	Belongs to the ABC transporter superfamily
JC283_RS01915	COG4608	Belongs to the ABC transporter superfamily
JC283_RS01920	COG0601	transmembrane transport
JC283_RS01925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JC283_RS01935	COG1760	l-serine dehydratase
JC283_RS01940	COG1760	l-serine dehydratase
JC283_RS01990	COG0471	metal ion transport
JC283_RS01995	COG2116	formate transmembrane transporter activity
JC283_RS02000	COG0454	-acetyltransferase
JC283_RS02010	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JC283_RS02010	COG1648	precorrin-2 dehydrogenase activity
JC283_RS02015	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JC283_RS02020	COG2146	nitrite reductase [NAD(P)H] activity
JC283_RS02025	COG1648	precorrin-2 dehydrogenase activity
JC283_RS02025	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JC283_RS02030	COG0737	Belongs to the 5'-nucleotidase family
JC283_RS02065	COG0018	arginyl-trna synthetase
JC283_RS02085	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
JC283_RS02090	COG1140	nitrate reductase beta subunit
JC283_RS02100	COG2181	nitrate reductase activity
JC283_RS02110	COG4585	Histidine kinase
JC283_RS02115	COG2197	response regulator
JC283_RS02120	COG2223	nitrite transmembrane transporter activity
JC283_RS02125	COG3344	reverse transcriptase
JC283_RS02130	COG4187	Peptidase family M20/M25/M40
JC283_RS02140	COG0039	L-malate dehydrogenase activity
JC283_RS02145	COG1363	Peptidase, m42
JC283_RS02150	COG0697	spore germination
JC283_RS02160	COG2807	transmembrane transport
JC283_RS02170	COG1263	PTS System
JC283_RS02170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JC283_RS02185	COG1283	sodium-dependent phosphate transmembrane transporter activity
JC283_RS02205	COG0492	ferredoxin-NADP+ reductase activity
JC283_RS02210	COG2814	Major facilitator Superfamily
JC283_RS02215	COG0604	alcohol dehydrogenase
JC283_RS02230	COG1620	l-lactate permease
JC283_RS02235	COG0438	transferase activity, transferring glycosyl groups
JC283_RS02240	COG0579	oxidoreductase
JC283_RS02255	COG0577	efflux transmembrane transporter activity
JC283_RS02290	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
JC283_RS02300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JC283_RS02320	COG1304	FMN binding
JC283_RS02325	COG0523	cobalamin synthesis protein
JC283_RS02330	COG0786	glutamate:sodium symporter activity
JC283_RS02335	COG2207	Transcriptional regulator
JC283_RS02340	COG3250	beta-galactosidase activity
JC283_RS02360	COG1757	Na H antiporter
JC283_RS02365	COG2094	Belongs to the DNA glycosylase MPG family
JC283_RS02370	COG3152	Membrane
JC283_RS02375	COG4152	abc transporter atp-binding protein
JC283_RS02380	COG1668	transmembrane transport
JC283_RS02385	COG1742	UPF0060 membrane protein
JC283_RS02390	COG2017	converts alpha-aldose to the beta-anomer
JC283_RS02395	COG2258	MOSC domain
JC283_RS02400	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
JC283_RS02410	COG1266	CAAX protease self-immunity
JC283_RS02435	COG2801	Transposase and inactivated derivatives
JC283_RS02495	COG1131	(ABC) transporter
JC283_RS02505	COG0583	DNA-binding transcription factor activity
JC283_RS02510	COG3314	Sporulation integral membrane protein YlbJ
JC283_RS02515	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
JC283_RS02520	COG1228	amidohydrolase
JC283_RS02525	COG0659	secondary active sulfate transmembrane transporter activity
JC283_RS02530	COG1473	amidohydrolase
JC283_RS02550	COG0385	Bile acid
JC283_RS02560	COG0346	lactoylglutathione lyase activity
JC283_RS02565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JC283_RS02590	COG1113	amino acid transport
JC283_RS02615	COG1316	TRANSCRIPTIONal
JC283_RS02630	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
JC283_RS02635	COG3383	formate dehydrogenase (NAD+) activity
JC283_RS02660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JC283_RS02665	COG2076	Multidrug Resistance protein
JC283_RS02670	COG2076	Multidrug Resistance protein
JC283_RS02675	COG3942	CHAP domain
JC283_RS02685	COG1757	Na H antiporter
JC283_RS02695	COG3942	CHAP domain
JC283_RS02715	COG3344	reverse transcriptase
JC283_RS02720	COG1960	acyl-CoA dehydrogenase activity
JC283_RS02725	COG2832	Protein of unknown function (DUF454)
JC283_RS02730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JC283_RS02735	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JC283_RS02745	COG2186	Transcriptional regulator
JC283_RS02755	COG1268	BioY protein
JC283_RS02770	COG1609	Transcriptional regulator
JC283_RS02775	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JC283_RS02780	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JC283_RS02785	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
JC283_RS02795	COG4149	molybdate abc transporter
JC283_RS02800	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
JC283_RS02805	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JC283_RS02810	COG0521	Mo-molybdopterin cofactor biosynthetic process
JC283_RS02830	COG0314	molybdopterin synthase activity
JC283_RS02840	COG0746	molybdenum cofactor guanylyltransferase activity
JC283_RS02845	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JC283_RS02870	COG2348	transferase activity, transferring amino-acyl groups
JC283_RS02875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JC283_RS02880	COG0436	Aminotransferase
JC283_RS02910	COG2252	PERMEase
JC283_RS02930	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JC283_RS02935	COG0088	Forms part of the polypeptide exit tunnel
JC283_RS02940	COG0089	rRNA binding
JC283_RS02945	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JC283_RS02950	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JC283_RS02955	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JC283_RS02960	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JC283_RS02965	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JC283_RS02970	COG0255	Belongs to the universal ribosomal protein uL29 family
JC283_RS02980	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JC283_RS02995	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JC283_RS03000	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JC283_RS03005	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JC283_RS03015	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JC283_RS03020	COG1841	ribosomal large subunit assembly
JC283_RS03030	COG0201	protein transport
JC283_RS03045	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JC283_RS03055	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JC283_RS03060	COG0202	RNA polymerase activity
JC283_RS03065	COG0203	ribosomal protein L17
JC283_RS03070	COG1122	ATPase activity
JC283_RS03075	COG1122	ATPase activity
JC283_RS03085	COG0101	tRNA pseudouridine synthase activity
JC283_RS03090	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JC283_RS03110	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JC283_RS03150	COG1349	DNA-binding transcription factor activity
JC283_RS03165	COG3684	Belongs to the aldolase LacD family
JC283_RS03175	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JC283_RS03175	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JC283_RS03185	COG0488	(ABC) transporter
JC283_RS03190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JC283_RS03200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JC283_RS03215	COG1302	Protein conserved in bacteria
JC283_RS03220	COG2814	Major facilitator Superfamily
JC283_RS03225	COG4264	IucA IucC family
JC283_RS03230	COG2814	Major facilitator Superfamily
JC283_RS03235	COG4264	IucA IucC family
JC283_RS03240	COG3457	Alanine racemase
JC283_RS03245	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
JC283_RS03250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JC283_RS03255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JC283_RS03260	COG3314	Sporulation integral membrane protein YlbJ
JC283_RS03270	COG1988	membrane-bound metal-dependent
JC283_RS03275	COG4284	Utp--glucose-1-phosphate uridylyltransferase
JC283_RS03280	COG1272	protein, Hemolysin III
JC283_RS03300	COG2814	Major facilitator Superfamily
JC283_RS03305	COG0489	protein tyrosine kinase activity
JC283_RS03370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JC283_RS03390	COG1119	ATPase activity
JC283_RS03395	COG0561	phosphatase activity
JC283_RS03405	COG2186	Transcriptional regulator
JC283_RS03410	COG1482	cell wall glycoprotein biosynthetic process
JC283_RS03425	COG1757	Na H antiporter
JC283_RS03435	COG0813	purine-nucleoside phosphorylase activity
JC283_RS03470	COG5146	pantothenate kinase activity
JC283_RS03485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JC283_RS03495	COG0504	CTP synthase activity
JC283_RS03500	COG2271	Major facilitator Superfamily
JC283_RS03505	COG4821	SIS domain
JC283_RS03510	COG0191	fructose-bisphosphate aldolase activity
JC283_RS03515	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JC283_RS03520	COG1733	regulation of RNA biosynthetic process
JC283_RS03530	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
JC283_RS03535	COG0254	rRNA binding
JC283_RS03545	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JC283_RS03550	COG2890	protein-(glutamine-N5) methyltransferase activity
JC283_RS03555	COG0009	L-threonylcarbamoyladenylate synthase
JC283_RS03560	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JC283_RS03565	COG4475	Protein of unknown function (DUF436)
JC283_RS03570	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JC283_RS03575	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JC283_RS03580	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
JC283_RS03590	COG0356	it plays a direct role in the translocation of protons across the membrane
JC283_RS03595	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JC283_RS03605	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JC283_RS03615	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JC283_RS03645	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JC283_RS03660	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
JC283_RS03670	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
JC283_RS03675	COG0352	thiamine-phosphate diphosphorylase activity
JC283_RS03680	COG0706	membrane insertase activity
JC283_RS03685	COG1418	mRNA catabolic process
JC283_RS03690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JC283_RS03695	COG1937	Protein conserved in bacteria
JC283_RS03710	COG2217	Heavy metal translocating P-type atpase
JC283_RS03725	COG0772	Belongs to the SEDS family
JC283_RS03730	COG1181	Belongs to the D-alanine--D-alanine ligase family
JC283_RS03735	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JC283_RS03740	COG0513	Belongs to the DEAD box helicase family
JC283_RS03755	COG3402	PFAM membrane-flanked domain
JC283_RS03760	COG0736	holo-[acyl-carrier-protein] synthase activity
JC283_RS03765	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JC283_RS03775	COG2337	Toxic component of a toxin-antitoxin (TA) module
JC283_RS03780	COG2208	phosphoserine phosphatase activity
JC283_RS03785	COG1366	Belongs to the anti-sigma-factor antagonist family
JC283_RS03795	COG1191	sigma factor activity
JC283_RS03800	COG2183	response to ionizing radiation
JC283_RS03805	COG3091	SprT-like family
JC283_RS03840	COG0515	serine threonine protein kinase
JC283_RS03860	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JC283_RS03870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JC283_RS03875	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JC283_RS03885	COG0028	Belongs to the TPP enzyme family
JC283_RS03890	COG0129	dihydroxy-acid dehydratase activity
JC283_RS03895	COG0802	atpase or kinase
JC283_RS03900	COG1214	PFAM Peptidase M22, glycoprotease
JC283_RS03905	COG0456	acetyltransferase
JC283_RS03910	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JC283_RS03915	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JC283_RS03920	COG0488	(ABC) transporter
JC283_RS03925	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
JC283_RS03930	COG2814	Major facilitator Superfamily
JC283_RS03935	COG1846	Transcriptional regulator
JC283_RS03945	COG2124	cytochrome p450
JC283_RS03950	COG1609	Transcriptional regulator
JC283_RS03955	COG1621	beta-fructofuranosidase activity
JC283_RS03960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JC283_RS03980	COG4512	PFAM Accessory gene regulator B
JC283_RS04025	COG1404	Belongs to the peptidase S8 family
JC283_RS04030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JC283_RS04035	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JC283_RS04055	COG1131	(ABC) transporter
JC283_RS04070	COG1070	Carbohydrate kinase
JC283_RS04075	COG2610	gluconate transmembrane transporter activity
JC283_RS04110	COG2706	6-phosphogluconolactonase activity
JC283_RS04115	COG1012	belongs to the aldehyde dehydrogenase family
JC283_RS04125	COG1227	inorganic diphosphatase activity
JC283_RS04130	COG1335	isochorismatase
JC283_RS04140	COG0077	Prephenate dehydratase
JC283_RS04150	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
JC283_RS04160	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
JC283_RS04170	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JC283_RS04175	COG4496	protein, YerC YecD
JC283_RS04180	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
JC283_RS04185	COG0210	DNA helicase
JC283_RS04190	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JC283_RS04195	COG4851	CamS sex pheromone cAM373 precursor
JC283_RS04200	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JC283_RS04205	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JC283_RS04215	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JC283_RS04220	COG1597	lipid kinase activity
JC283_RS04245	COG0488	(ABC) transporter
JC283_RS04255	COG1396	sequence-specific DNA binding
JC283_RS04265	COG2211	Major facilitator Superfamily
JC283_RS04275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JC283_RS04285	COG1528	Iron-storage protein
JC283_RS04300	COG4129	membrane
JC283_RS04305	COG0024	Methionine aminopeptidase
JC283_RS04330	COG0288	reversible hydration of carbon dioxide
JC283_RS04335	COG1295	ribonuclease BN
JC283_RS04350	COG4840	Belongs to the UPF0435 family
JC283_RS04355	COG2309	aminopeptidase activity
JC283_RS04360	COG1607	acyl-coa hydrolase
JC283_RS04365	COG0535	radical SAM domain protein
JC283_RS04375	COG0693	protein deglycase activity
JC283_RS04380	COG0028	Belongs to the TPP enzyme family
JC283_RS04385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JC283_RS04390	COG2137	regulation of response to DNA damage stimulus
JC283_RS04400	COG1134	teichoic acid transport
JC283_RS04400	COG1388	LysM domain
JC283_RS04410	COG1988	membrane-bound metal-dependent
JC283_RS04415	COG1194	a g-specific adenine glycosylase
JC283_RS04420	COG3557	Belongs to the UPF0374 family
JC283_RS04430	COG0069	glutamate synthase activity
JC283_RS04435	COG4129	membrane
JC283_RS04440	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JC283_RS04445	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JC283_RS04455	COG0735	belongs to the Fur family
JC283_RS04620	COG0765	amino acid transport
JC283_RS04625	COG1126	abc transporter atp-binding protein
JC283_RS04630	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JC283_RS04640	COG0363	glucosamine-6-phosphate deaminase activity
JC283_RS04655	COG0114	fumarate hydratase activity
JC283_RS04660	COG0248	Ppx GppA phosphatase
JC283_RS04665	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
JC283_RS04670	COG0564	pseudouridine synthase activity
JC283_RS04675	COG4585	Histidine kinase
JC283_RS04675	COG2203	Gaf domain
JC283_RS04680	COG2197	response regulator
JC283_RS04690	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
JC283_RS04700	COG4399	Belongs to the UPF0754 family
JC283_RS04705	COG3679	Belongs to the UPF0342 family
JC283_RS04710	COG0420	3'-5' exonuclease activity
JC283_RS04720	COG3481	metal-dependent phosphohydrolase, HD sub domain
JC283_RS04725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JC283_RS04740	COG1846	Transcriptional regulator
JC283_RS04750	COG0537	adenosine 5'-monophosphoramidase activity
JC283_RS04755	COG1131	(ABC) transporter
JC283_RS04760	COG4473	ABC transporter
JC283_RS04765	COG3344	reverse transcriptase
JC283_RS04775	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JC283_RS04785	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
JC283_RS04790	COG3545	Serine hydrolase
JC283_RS04840	COG0582	viral genome integration into host DNA
JC283_RS04860	COG1395	domain, Protein
JC283_RS05090	COG4824	toxin secretion phage lysis holin
JC283_RS05150	COG3037	sugar-specific permease SgaT UlaA
JC283_RS05170	COG3623	hexulose-6-phosphate isomerase
JC283_RS05175	COG0235	Class ii aldolase
JC283_RS05195	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
JC283_RS05200	COG0494	nUDIX hydrolase
JC283_RS05205	COG1506	peptidase
JC283_RS05210	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
JC283_RS05215	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JC283_RS05225	COG0656	L-ascorbic acid biosynthetic process
JC283_RS05230	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JC283_RS05235	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JC283_RS05245	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JC283_RS05270	COG3266	domain, Protein
JC283_RS05270	COG5632	N-Acetylmuramoyl-L-alanine amidase
JC283_RS05270	COG4193	domain, Protein
JC283_RS05280	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JC283_RS05280	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JC283_RS05285	COG0307	riboflavin synthase, alpha
JC283_RS05290	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JC283_RS05290	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JC283_RS05295	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
JC283_RS05310	COG2267	carboxylic ester hydrolase activity
JC283_RS05315	COG0039	L-malate dehydrogenase activity
JC283_RS05325	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
JC283_RS05330	COG1242	4 iron, 4 sulfur cluster binding
JC283_RS05335	COG2814	Major facilitator Superfamily
JC283_RS05340	COG0495	leucyl-tRNA aminoacylation
JC283_RS05345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JC283_RS05350	COG2081	HI0933 family
JC283_RS05355	COG2244	polysaccharide biosynthetic process
JC283_RS05360	COG1187	pseudouridine synthase activity
JC283_RS05370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JC283_RS05375	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JC283_RS05380	COG0510	thiamine kinase activity
JC283_RS05385	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JC283_RS05390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JC283_RS05400	COG1363	Peptidase, m42
JC283_RS05405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JC283_RS05410	COG4848	Belongs to the UPF0354 family
JC283_RS05415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JC283_RS05420	COG1674	ftsk spoiiie
JC283_RS05425	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JC283_RS05430	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
JC283_RS05440	COG1605	Chorismate mutase
JC283_RS05440	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
JC283_RS05445	COG1609	Transcriptional regulator
JC283_RS05455	COG0454	-acetyltransferase
JC283_RS05460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JC283_RS05465	COG2759	Belongs to the formate--tetrahydrofolate ligase family
JC283_RS05470	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
JC283_RS05480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JC283_RS05485	COG0204	Acyl-transferase
JC283_RS05495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JC283_RS05500	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JC283_RS05505	COG1764	response to oxidative stress
JC283_RS05540	COG0456	acetyltransferase
JC283_RS05565	COG3344	reverse transcriptase
JC283_RS05580	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JC283_RS05585	COG1956	GAF domain-containing protein
JC283_RS05590	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
JC283_RS05595	COG1104	cysteine desulfurase activity
JC283_RS05600	COG0301	tRNA thio-modification
JC283_RS05610	COG0616	signal peptide processing
JC283_RS05615	COG1714	RDD family
JC283_RS05620	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
JC283_RS05625	COG0827	DNA restriction-modification system
JC283_RS05630	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JC283_RS05635	COG0589	response to stress
JC283_RS05640	COG0686	Belongs to the AlaDH PNT family
JC283_RS05650	COG0006	proline dipeptidase activity
JC283_RS05655	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
JC283_RS05665	COG4109	DRTGG domain
JC283_RS05670	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
JC283_RS05675	COG0587	DNA-directed DNA polymerase activity
JC283_RS05680	COG0281	malic enzyme
JC283_RS05685	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JC283_RS05690	COG0825	malonyl-CoA metabolic process
JC283_RS05695	COG0205	6-phosphofructokinase activity
JC283_RS05700	COG0469	pyruvate kinase activity
JC283_RS05705	COG0372	Belongs to the citrate synthase family
JC283_RS05710	COG0538	isocitrate dehydrogenase activity
JC283_RS05715	COG0745	RESPONSE REGULATOR receiver
JC283_RS05720	COG5002	protein histidine kinase activity
JC283_RS05725	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JC283_RS05725	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JC283_RS05735	COG0237	dephospho-CoA kinase activity
JC283_RS05750	COG3611	Membrane attachment protein
JC283_RS05755	COG1484	DNA-dependent DNA replication
JC283_RS05765	COG0833	amino acid
JC283_RS05775	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JC283_RS05780	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JC283_RS05785	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
JC283_RS05800	COG0544	peptidyl-prolyl cis-trans isomerase activity
JC283_RS05815	COG0218	Necessary for normal cell division and for the maintenance of normal septation
JC283_RS05820	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JC283_RS05830	COG0181	hydroxymethylbilane synthase activity
JC283_RS05845	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JC283_RS05855	COG2818	Glycosylase
JC283_RS05860	COG0525	valine-tRNA ligase activity
JC283_RS05865	COG0285	dihydrofolate synthase activity
JC283_RS05875	COG2003	Belongs to the UPF0758 family
JC283_RS05915	COG2868	ribosomal protein
JC283_RS05925	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JC283_RS05935	COG0632	four-way junction helicase activity
JC283_RS05945	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
JC283_RS05955	COG1862	Preprotein translocase
JC283_RS05960	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JC283_RS05960	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JC283_RS05965	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
JC283_RS05965	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JC283_RS05970	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JC283_RS05980	COG1490	D-aminoacyl-tRNA deacylase activity
JC283_RS05985	COG0860	N-Acetylmuramoyl-L-alanine amidase
JC283_RS05995	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JC283_RS06005	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JC283_RS06010	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JC283_RS06015	COG1959	2 iron, 2 sulfur cluster binding
JC283_RS06030	COG3344	reverse transcriptase
JC283_RS06035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JC283_RS06040	COG1104	cysteine desulfurase activity
JC283_RS06045	COG0482	sulfurtransferase activity
JC283_RS06055	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JC283_RS06060	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JC283_RS06065	COG4472	Bacterial protein of unknown function (DUF965)
JC283_RS06070	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JC283_RS06075	COG3906	Belongs to the UPF0473 family
JC283_RS06080	COG4122	O-methyltransferase activity
JC283_RS06085	COG0826	peptidase U32
JC283_RS06090	COG0826	peptidase U32
JC283_RS06095	COG0572	uridine kinase
JC283_RS06105	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JC283_RS06110	COG1984	allophanate hydrolase subunit 2
JC283_RS06115	COG0511	ligase activity, forming carbon-carbon bonds
JC283_RS06120	COG0439	Biotin carboxylase
JC283_RS06125	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
JC283_RS06130	COG1914	H( )-stimulated, divalent metal cation uptake system
JC283_RS06135	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JC283_RS06140	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
JC283_RS06145	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
JC283_RS06150	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JC283_RS06155	COG1534	Rna-binding protein
JC283_RS06165	COG1713	HD superfamily hydrolase involved in NAD metabolism
JC283_RS06170	COG0799	negative regulation of ribosome biogenesis
JC283_RS06175	COG2226	methyltransferase
JC283_RS06180	COG1596	polysaccharide export
JC283_RS06180	COG1555	photosystem II stabilization
JC283_RS06185	COG2131	deaminase
JC283_RS06190	COG2333	competence protein COMEC
JC283_RS06190	COG0658	competence protein
JC283_RS06195	COG1466	dna polymerase III delta subunit
JC283_RS06200	COG0268	Binds directly to 16S ribosomal RNA
JC283_RS06210	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JC283_RS06225	COG0443	Heat shock 70 kDa protein
JC283_RS06230	COG0484	heat shock protein binding
JC283_RS06235	COG2264	protein methyltransferase activity
JC283_RS06240	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JC283_RS06245	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JC283_RS06260	COG1030	water channel activity
JC283_RS06265	COG4864	UPF0365 protein
JC283_RS06275	COG1702	phosphate starvation-inducible protein PhoH
JC283_RS06285	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JC283_RS06295	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JC283_RS06300	COG1381	Involved in DNA repair and RecF pathway recombination
JC283_RS06305	COG0423	glycine-tRNA ligase activity
JC283_RS06310	COG0517	IMP dehydrogenase activity
JC283_RS06315	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JC283_RS06320	COG0358	DNA primase activity
JC283_RS06325	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JC283_RS06330	COG2384	SAM-dependent methyltransferase
JC283_RS06335	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JC283_RS06340	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JC283_RS06345	COG0513	Belongs to the DEAD box helicase family
JC283_RS06350	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
JC283_RS06355	COG1121	(ABC) transporter
JC283_RS06360	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JC283_RS06365	COG0735	belongs to the Fur family
JC283_RS06370	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JC283_RS06380	COG0768	penicillin binding
JC283_RS06385	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JC283_RS06390	COG0573	inorganic phosphate transmembrane transporter activity
JC283_RS06395	COG0581	inorganic phosphate transmembrane transporter activity
JC283_RS06400	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JC283_RS06405	COG0704	Plays a role in the regulation of phosphate uptake
JC283_RS06415	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JC283_RS06420	COG0705	Rhomboid family
JC283_RS06420	COG0457	Tetratricopeptide repeat
JC283_RS06425	COG4483	Protein conserved in bacteria
JC283_RS06430	COG1940	carbohydrate kinase activity
JC283_RS06435	COG0011	TIGRFAM Protein of
JC283_RS06440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JC283_RS06445	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JC283_RS06475	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JC283_RS06480	COG0404	The glycine cleavage system catalyzes the degradation of glycine
JC283_RS06490	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JC283_RS06495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JC283_RS06500	COG0095	Lipoate-protein ligase
JC283_RS06515	COG0006	proline dipeptidase activity
JC283_RS06520	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JC283_RS06525	COG0511	ligase activity, forming carbon-carbon bonds
JC283_RS06530	COG0439	Biotin carboxylase
JC283_RS06535	COG1302	Protein conserved in bacteria
JC283_RS06545	COG1570	exodeoxyribonuclease VII activity
JC283_RS06550	COG1722	exodeoxyribonuclease VII activity
JC283_RS06555	COG0142	geranyltranstransferase activity
JC283_RS06560	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JC283_RS06565	COG1438	arginine binding
JC283_RS06570	COG0497	DNA recombination
JC283_RS06575	COG0280	phosphate acetyltransferase
JC283_RS06580	COG3426	butyrate kinase activity
JC283_RS06585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JC283_RS06590	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
JC283_RS06595	COG0022	dehydrogenase e1 component
JC283_RS06600	COG0508	dehydrogenase complex catalyzes the overall conversion of
JC283_RS06610	COG4129	membrane
JC283_RS06620	COG2195	Cleaves the N-terminal amino acid of tripeptides
JC283_RS06650	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
JC283_RS06655	COG1234	tRNA 3'-trailer cleavage
JC283_RS06660	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JC283_RS06670	COG0667	Aldo Keto reductase
JC283_RS06675	COG0494	nUDIX hydrolase
JC283_RS06680	COG0735	belongs to the Fur family
JC283_RS06695	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
JC283_RS06700	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
JC283_RS06705	COG1187	pseudouridine synthase activity
JC283_RS06710	COG0745	RESPONSE REGULATOR receiver
JC283_RS06725	COG1141	Ferredoxin
JC283_RS06735	COG0514	ATP-dependent DNA helicase (RecQ)
JC283_RS06745	COG0492	ferredoxin-NADP+ reductase activity
JC283_RS06750	COG0252	asparaginase activity
JC283_RS06760	COG0539	negative regulation of cytoplasmic translation
JC283_RS06765	COG1160	GTP binding
JC283_RS06770	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JC283_RS06790	COG0142	geranyltranstransferase activity
JC283_RS06795	COG0105	UTP biosynthetic process
JC283_RS06805	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JC283_RS06810	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JC283_RS06815	COG0457	Tetratricopeptide repeat
JC283_RS06820	COG5582	Belongs to the UPF0302 family
JC283_RS06825	COG4347	Protein of unknown function (DUF1405)
JC283_RS06835	COG1694	Mazg nucleotide pyrophosphohydrolase
JC283_RS06840	COG0438	transferase activity, transferring glycosyl groups
JC283_RS06845	COG0617	tRNA 3'-terminal CCA addition
JC283_RS06860	COG0017	Asparaginyl-tRNA synthetase
JC283_RS06865	COG3935	DnaD domain protein
JC283_RS06870	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JC283_RS06880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JC283_RS06880	COG4499	WXG100 protein secretion system (Wss), protein YukC
JC283_RS06895	COG4474	Belongs to the UPF0398 family
JC283_RS06900	COG3599	regulation of cell shape
JC283_RS06910	COG0116	Belongs to the methyltransferase superfamily
JC283_RS06915	COG2962	Rard protein
JC283_RS06920	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
JC283_RS06925	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JC283_RS06935	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
JC283_RS06945	COG1413	lyase activity
JC283_RS06980	COG2190	(PTS) system
JC283_RS06990	COG0793	Belongs to the peptidase S41A family
JC283_RS07000	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JC283_RS07005	COG0671	phosphoesterase, PA-phosphatase related
JC283_RS07015	COG5002	protein histidine kinase activity
JC283_RS07020	COG0567	Dehydrogenase, E1 component
JC283_RS07045	COG0714	Associated with various cellular activities
JC283_RS07050	COG4548	von Willebrand factor, type A
JC283_RS07055	COG1114	Component of the transport system for branched-chain amino acids
JC283_RS07060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JC283_RS07070	COG3853	Toxic anion resistance protein (TelA)
JC283_RS07090	COG1278	Cold shock
JC283_RS07110	COG1473	amidohydrolase
JC283_RS07115	COG2171	N-acyltransferase activity
JC283_RS07120	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JC283_RS07125	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JC283_RS07130	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JC283_RS07135	COG0488	(ABC) transporter
JC283_RS07140	COG2996	Protein conserved in bacteria
JC283_RS07170	COG1363	Peptidase, m42
JC283_RS07175	COG0287	Prephenate dehydrogenase
JC283_RS07180	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JC283_RS07190	COG1942	4-Oxalocrotonate Tautomerase
JC283_RS07210	COG0628	permease
JC283_RS07220	COG3711	transcriptional antiterminator
JC283_RS07225	COG1115	amino acid carrier protein
JC283_RS07230	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JC283_RS07240	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
JC283_RS07245	COG4841	protein insertion into membrane
JC283_RS07250	COG0824	Thioesterase
JC283_RS07260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JC283_RS07265	COG1970	mechanosensitive ion channel activity
JC283_RS07270	COG0419	ATPase involved in DNA repair
JC283_RS07275	COG0420	3'-5' exonuclease activity
JC283_RS07280	COG4846	Membrane protein involved in cytochrome C biogenesis
JC283_RS07285	COG3763	UPF0154 protein
JC283_RS07295	COG4224	UPF0291 protein
JC283_RS07305	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JC283_RS07315	COG0516	GMP reductase activity
JC283_RS07320	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JC283_RS07330	COG0833	amino acid
JC283_RS07345	COG0083	homoserine kinase activity
JC283_RS07350	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
JC283_RS07355	COG0460	homoserine dehydrogenase
JC283_RS07360	COG0527	aspartate kinase activity
JC283_RS07380	COG3344	reverse transcriptase
JC283_RS07385	COG1525	nuclease
JC283_RS07415	COG0584	glycerophosphoryl diester phosphodiesterase
JC283_RS07435	COG0789	Transcriptional regulator
JC283_RS07440	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
JC283_RS07445	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JC283_RS07450	COG0386	Belongs to the glutathione peroxidase family
JC283_RS07455	COG2267	carboxylic ester hydrolase activity
JC283_RS07460	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JC283_RS07465	COG1923	regulation of RNA biosynthetic process
JC283_RS07470	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JC283_RS07480	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JC283_RS07485	COG1619	proteins homologs of microcin C7 resistance protein MccF
JC283_RS07490	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
JC283_RS07495	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
JC283_RS07515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JC283_RS07525	COG1013	pyruvate-flavodoxin oxidoreductase activity
JC283_RS07530	COG0674	pyruvate-flavodoxin oxidoreductase activity
JC283_RS07530	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JC283_RS07535	COG1692	metallophosphoesterase
JC283_RS07555	COG1418	mRNA catabolic process
JC283_RS07560	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JC283_RS07565	COG1058	Belongs to the CinA family
JC283_RS07565	COG1546	Belongs to the CinA family
JC283_RS07585	COG0300	oxidoreductase activity
JC283_RS07590	COG0612	Peptidase, M16
JC283_RS07595	COG0612	Peptidase, M16
JC283_RS07600	COG2188	Transcriptional regulator
JC283_RS07615	COG1185	polyribonucleotide nucleotidyltransferase activity
JC283_RS07625	COG0196	riboflavin kinase activity
JC283_RS07630	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JC283_RS07635	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JC283_RS07645	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JC283_RS07650	COG1358	cellular component organization or biogenesis
JC283_RS07655	COG2740	Nucleic-acid-binding protein implicated in transcription termination
JC283_RS07660	COG0195	Participates in both transcription termination and antitermination
JC283_RS07665	COG0779	Required for maturation of 30S ribosomal subunits
JC283_RS07675	COG0442	prolyl-tRNA aminoacylation
JC283_RS07685	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
JC283_RS07690	COG4589	Belongs to the CDS family
JC283_RS07700	COG0233	cytoplasmic translational termination
JC283_RS07705	COG0528	UMP kinase activity
JC283_RS07710	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JC283_RS07715	COG0052	Belongs to the universal ribosomal protein uS2 family
JC283_RS07720	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
JC283_RS07725	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
JC283_RS07730	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
JC283_RS07735	COG4974	Belongs to the 'phage' integrase family
JC283_RS07740	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
JC283_RS07745	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JC283_RS07750	COG0758	DNA mediated transformation
JC283_RS07760	COG0045	succinate-CoA ligase (ADP-forming) activity
JC283_RS07770	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JC283_RS07785	COG4485	Bacterial membrane protein, YfhO
JC283_RS07820	COG0336	Belongs to the RNA methyltransferase TrmD family
JC283_RS07825	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JC283_RS07830	COG0228	four-way junction DNA binding
JC283_RS07850	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
JC283_RS07865	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JC283_RS07870	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
JC283_RS07875	COG0552	protein localization to endoplasmic reticulum
JC283_RS07880	COG1196	nuclear chromosome segregation
JC283_RS07885	COG0571	ribonuclease III activity
JC283_RS07890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JC283_RS07905	COG0416	fatty acid biosynthetic process
JC283_RS07910	COG1349	DNA-binding transcription factor activity
JC283_RS07920	COG1760	l-serine dehydratase
JC283_RS07925	COG1760	l-serine dehydratase
JC283_RS07935	COG1302	Protein conserved in bacteria
JC283_RS07950	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JC283_RS07955	COG1162	GTPase activity
JC283_RS07965	COG2124	cytochrome p450
JC283_RS07980	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JC283_RS07985	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JC283_RS07985	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JC283_RS07990	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JC283_RS07995	COG0242	peptide deformylase activity
JC283_RS08000	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JC283_RS08005	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JC283_RS08025	COG1758	RNA polymerase activity
JC283_RS08045	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JC283_RS08050	COG0284	orotidine-5'-phosphate decarboxylase activity
JC283_RS08055	COG0167	dihydroorotate dehydrogenase activity
JC283_RS08065	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JC283_RS08070	COG0505	Belongs to the CarA family
JC283_RS08090	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
JC283_RS08095	COG0564	pseudouridine synthase activity
JC283_RS08100	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JC283_RS08105	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JC283_RS08110	COG3599	regulation of cell shape
JC283_RS08120	COG0673	inositol 2-dehydrogenase activity
JC283_RS08125	COG4409	exo-alpha-(2->6)-sialidase activity
JC283_RS08135	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JC283_RS08140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JC283_RS08150	COG4975	Glucose uptake
JC283_RS08155	COG1869	D-ribose catabolic process
JC283_RS08160	COG0762	integral membrane protein
JC283_RS08165	COG1799	cell septum assembly
JC283_RS08170	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JC283_RS08180	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JC283_RS08185	COG0849	cell division
JC283_RS08195	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
JC283_RS08205	COG0768	penicillin binding
JC283_RS08210	COG4839	cell division protein FtsL
JC283_RS08215	COG0275	rRNA processing
JC283_RS08220	COG2001	Belongs to the MraZ family
JC283_RS08225	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
JC283_RS08230	COG0454	-acetyltransferase
JC283_RS08235	COG1011	Hydrolase
JC283_RS08250	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JC283_RS08310	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JC283_RS08315	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JC283_RS08320	COG1053	succinate dehydrogenase
JC283_RS08325	COG2009	succinate dehydrogenase
JC283_RS08330	COG0322	excinuclease ABC activity
JC283_RS08335	COG3118	belongs to the thioredoxin family
JC283_RS08340	COG1193	negative regulation of DNA recombination
JC283_RS08345	COG1796	DNA polymerase
JC283_RS08345	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JC283_RS08360	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JC283_RS08375	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JC283_RS08380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JC283_RS08385	COG0333	Belongs to the bacterial ribosomal protein bL32 family
JC283_RS08405	COG0742	ribosomal rna small subunit methyltransferase
JC283_RS08415	COG4471	UPF0298 protein
JC283_RS08420	COG0584	glycerophosphoryl diester phosphodiesterase
JC283_RS08425	COG3679	Belongs to the UPF0342 family
JC283_RS08440	COG0109	protoheme IX farnesyltransferase activity
JC283_RS08460	COG3344	reverse transcriptase
JC283_RS08465	COG0772	Belongs to the SEDS family
JC283_RS08470	COG4838	Belongs to the UPF0358 family
JC283_RS08475	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
JC283_RS08480	COG4896	Protein conserved in bacteria
JC283_RS08485	COG1902	pentaerythritol trinitrate reductase activity
JC283_RS08490	COG1217	gtp-binding protein TYPA
JC283_RS08500	COG0483	inositol monophosphate 1-phosphatase activity
JC283_RS08505	COG4493	Belongs to the UPF0637 family
JC283_RS08520	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
JC283_RS08525	COG1177	transmembrane transport
JC283_RS08535	COG3842	ATPase activity
JC283_RS08545	COG4476	Belongs to the UPF0223 family
JC283_RS08590	COG5503	Protein of unknown function (DUF1447)
JC283_RS08595	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
JC283_RS08605	COG0492	ferredoxin-NADP+ reductase activity
JC283_RS08625	COG3344	reverse transcriptase
JC283_RS08630	COG0569	domain protein
JC283_RS08635	COG1294	oxidase, subunit
JC283_RS08640	COG1271	oxidase subunit
JC283_RS08645	COG1393	Belongs to the ArsC family
JC283_RS08655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JC283_RS08660	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JC283_RS08670	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JC283_RS08690	COG4172	Belongs to the ABC transporter superfamily
JC283_RS08700	COG0151	Belongs to the GarS family
JC283_RS08705	COG0138	bifunctional purine biosynthesis protein purh
JC283_RS08715	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JC283_RS08720	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
JC283_RS08730	COG0047	phosphoribosylformylglycinamidine synthase activity
JC283_RS08735	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JC283_RS08740	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JC283_RS08745	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
JC283_RS08750	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JC283_RS08755	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JC283_RS08760	COG1017	nitric oxide dioxygenase activity
JC283_RS08760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JC283_RS08770	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JC283_RS08780	COG1845	cytochrome c oxidase, subunit III
JC283_RS08785	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
JC283_RS08795	COG3973	AAA domain
JC283_RS08835	COG3212	peptidase
JC283_RS08850	COG1134	teichoic acid transport
JC283_RS08860	COG1682	transport, permease protein
JC283_RS08870	COG1215	transferase activity, transferring glycosyl groups
JC283_RS08880	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
JC283_RS08885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JC283_RS08890	COG1316	TRANSCRIPTIONal
JC283_RS08915	COG3594	Acyltransferase
JC283_RS08920	COG0436	Aminotransferase
JC283_RS08925	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
JC283_RS08935	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
JC283_RS08940	COG1169	isochorismate synthase
JC283_RS08945	COG1575	Belongs to the MenA family. Type 1 subfamily
JC283_RS08950	COG0390	transport system, permease component
JC283_RS08955	COG4619	ABC transporter
JC283_RS08975	COG4873	Protein conserved in bacteria
JC283_RS09055	COG2378	regulation of single-species biofilm formation
JC283_RS09065	COG0456	acetyltransferase
JC283_RS09075	COG2226	methyltransferase
JC283_RS09140	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JC283_RS09160	COG0737	Belongs to the 5'-nucleotidase family
JC283_RS09170	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JC283_RS09175	COG1696	Membrane protein involved in D-alanine export
JC283_RS09185	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
JC283_RS09190	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JC283_RS09195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JC283_RS09200	COG0861	Integral membrane protein TerC family
JC283_RS09205	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
JC283_RS09215	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JC283_RS09220	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JC283_RS09225	COG2814	Major facilitator Superfamily
JC283_RS09235	COG3715	PTS system
JC283_RS09240	COG3716	PTS system mannose fructose sorbose family IID component
JC283_RS09245	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
JC283_RS09250	COG2382	esterase
JC283_RS09255	COG1115	amino acid carrier protein
JC283_RS09260	COG0628	permease
JC283_RS09270	COG0569	domain protein
JC283_RS09270	COG0475	glutathione-regulated potassium exporter activity
JC283_RS09275	COG2239	Acts as a magnesium transporter
JC283_RS09280	COG0564	pseudouridine synthase activity
JC283_RS09290	COG2357	RelA SpoT domain protein
JC283_RS09305	COG2346	COG2346, Truncated hemoglobins
JC283_RS09310	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
JC283_RS09320	COG1164	Oligoendopeptidase f
JC283_RS09345	COG1393	Belongs to the ArsC family
JC283_RS09350	COG0180	Tryptophanyl-tRNA synthetase
JC283_RS09355	COG4166	transmembrane transport
JC283_RS09360	COG4608	Belongs to the ABC transporter superfamily
JC283_RS09365	COG0444	Belongs to the ABC transporter superfamily
JC283_RS09370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JC283_RS09375	COG0601	transmembrane transport
JC283_RS09400	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
JC283_RS09420	COG0561	phosphatase activity
JC283_RS09425	COG0446	pyridine nucleotide-disulphide oxidoreductase
JC283_RS09430	COG3344	reverse transcriptase
JC283_RS09440	COG0179	Fumarylacetoacetate (FAA) hydrolase
JC283_RS09450	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
JC283_RS09465	COG0166	Belongs to the GPI family
JC283_RS09470	COG0137	argininosuccinate synthase activity
JC283_RS09480	COG0584	glycerophosphoryl diester phosphodiesterase
JC283_RS09495	COG1012	belongs to the aldehyde dehydrogenase family
JC283_RS09500	COG1098	S1 RNA binding domain
JC283_RS09510	COG1278	Cold shock
JC283_RS09530	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JC283_RS09540	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JC283_RS09540	COG2111	Na H antiporter
JC283_RS09545	COG2111	Na H antiporter
JC283_RS09550	COG1006	Multisubunit Na H antiporter MnhC subunit
JC283_RS09555	COG0651	ATP synthesis coupled electron transport
JC283_RS09560	COG1863	multisubunit Na H antiporter MnhE subunit
JC283_RS09565	COG2212	antiporter activity
JC283_RS09570	COG1320	monovalent cation:proton antiporter activity
JC283_RS09580	COG2056	Na+-H+ antiporter family
JC283_RS09585	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JC283_RS09590	COG1252	NADH dehydrogenase
JC283_RS09595	COG0316	Belongs to the HesB IscA family
JC283_RS09600	COG4844	belongs to the
JC283_RS09605	COG1252	NADH dehydrogenase
JC283_RS09610	COG4837	Protein of unknown function (DUF1462)
JC283_RS09615	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
JC283_RS09620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JC283_RS09625	COG0647	UMP catabolic process
JC283_RS09630	COG2445	Protein of unknown function DUF86
JC283_RS09640	COG4470	Protein conserved in bacteria
JC283_RS09645	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JC283_RS09650	COG0737	Belongs to the 5'-nucleotidase family
JC283_RS09655	COG0730	response to heat
JC283_RS09660	COG1801	Protein of unknown function DUF72
JC283_RS09675	COG1253	flavin adenine dinucleotide binding
JC283_RS09685	COG0719	Fe-S assembly protein
JC283_RS09690	COG0822	iron-sulfur transferase activity
JC283_RS09700	COG0719	Fe-S assembly protein
JC283_RS09705	COG0396	ATPase activity
JC283_RS09720	COG1464	Belongs to the NlpA lipoprotein family
JC283_RS09725	COG1464	Belongs to the NlpA lipoprotein family
JC283_RS09730	COG2011	ABC-type metal ion transport system permease component
JC283_RS09740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JC283_RS09745	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
JC283_RS09755	COG1393	Belongs to the ArsC family
JC283_RS09760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JC283_RS09770	COG0710	3-dehydroquinate dehydratase activity
JC283_RS09780	COG1764	response to oxidative stress
JC283_RS09795	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JC283_RS09815	COG0346	lactoylglutathione lyase activity
JC283_RS09845	COG0557	exoribonuclease II activity
JC283_RS09850	COG1647	Serine aminopeptidase, S33
JC283_RS09855	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JC283_RS09875	COG0148	phosphopyruvate hydratase activity
JC283_RS09880	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
JC283_RS09910	COG1090	epimerase
JC283_RS09920	COG0740	serine-type endopeptidase activity
JC283_RS09930	COG1481	regulation of sporulation
JC283_RS09935	COG0391	Required for morphogenesis under gluconeogenic growth conditions
JC283_RS09940	COG1660	Displays ATPase and GTPase activities
JC283_RS09955	COG0110	maltose O-acetyltransferase activity
JC283_RS09960	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JC283_RS09965	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
JC283_RS10000	COG0653	protein targeting
JC283_RS10015	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
JC283_RS10025	COG1739	Uncharacterized protein family UPF0029
JC283_RS10030	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JC283_RS10050	COG2195	Cleaves the N-terminal amino acid of tripeptides
JC283_RS10055	COG1929	Belongs to the glycerate kinase type-1 family
JC283_RS10060	COG3118	belongs to the thioredoxin family
JC283_RS10075	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JC283_RS10085	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JC283_RS10090	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JC283_RS10135	COG2801	Transposase and inactivated derivatives
JC283_RS10145	COG3104	oligopeptide transport
JC283_RS10150	COG3104	oligopeptide transport
JC283_RS10165	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JC283_RS10170	COG1174	glycine betaine transport
JC283_RS10175	COG0517	IMP dehydrogenase activity
JC283_RS10175	COG1125	glycine betaine transport
JC283_RS10180	COG0514	ATP-dependent DNA helicase (RecQ)
JC283_RS10185	COG0488	(ABC) transporter
JC283_RS10205	COG0463	Glycosyl transferase, family 2
JC283_RS10210	COG1368	sulfuric ester hydrolase activity
JC283_RS10220	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JC283_RS10240	COG0512	Glutamine amidotransferase of anthranilate synthase
JC283_RS10250	COG0720	synthase
JC283_RS10255	COG0602	queuosine metabolic process
JC283_RS10275	COG0463	Glycosyl transferase, family 2
JC283_RS10280	COG1253	flavin adenine dinucleotide binding
JC283_RS10285	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JC283_RS10285	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JC283_RS10285	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JC283_RS10290	COG1105	Belongs to the carbohydrate kinase PfkB family
JC283_RS10295	COG1349	DNA-binding transcription factor activity
JC283_RS10315	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JC283_RS10320	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JC283_RS10340	COG0039	L-malate dehydrogenase activity
JC283_RS10355	COG4989	oxidoreductase activity
JC283_RS10360	COG0523	cobalamin synthesis protein
JC283_RS10370	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
JC283_RS10375	COG4988	ABC transporter
JC283_RS10380	COG1968	undecaprenyl-diphosphatase activity
JC283_RS10390	COG1671	Belongs to the UPF0178 family
JC283_RS10395	COG1611	Belongs to the LOG family
JC283_RS10425	COG2839	Protein conserved in bacteria
JC283_RS10430	COG2814	Major facilitator Superfamily
JC283_RS10435	COG0583	DNA-binding transcription factor activity
JC283_RS10450	COG0217	transcriptional regulatory protein
JC283_RS10455	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JC283_RS10460	COG2022	thiamine diphosphate biosynthetic process
JC283_RS10470	COG0352	thiamine-phosphate diphosphorylase activity
JC283_RS10480	COG1388	LysM domain
JC283_RS10480	COG3942	CHAP domain
JC283_RS10485	COG0306	phosphate transporter
JC283_RS10490	COG1392	Phosphate transport regulator
JC283_RS10495	COG0577	efflux transmembrane transporter activity
JC283_RS10500	COG1136	(ABC) transporter
JC283_RS10510	COG0745	RESPONSE REGULATOR receiver
JC283_RS10515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JC283_RS10520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JC283_RS10530	COG3949	Membrane
JC283_RS10535	COG0477	Major facilitator Superfamily
JC283_RS10545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JC283_RS10550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JC283_RS10555	COG1120	ATPase activity
JC283_RS10560	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JC283_RS10570	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JC283_RS10590	COG1132	(ABC) transporter
JC283_RS10595	COG1686	Belongs to the peptidase S11 family
JC283_RS10615	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
JC283_RS10620	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
JC283_RS10625	COG1682	transport, permease protein
JC283_RS10635	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
JC283_RS10640	COG0110	maltose O-acetyltransferase activity
JC283_RS10650	COG1475	DNA binding
JC283_RS10655	COG0019	diaminopimelate decarboxylase activity
JC283_RS10665	COG4264	IucA IucC family
JC283_RS10670	COG4264	IucA IucC family
JC283_RS10675	COG2814	Major facilitator Superfamily
JC283_RS10680	COG4264	IucA IucC family
JC283_RS10685	COG2423	ornithine cyclodeaminase activity
JC283_RS10695	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JC283_RS10700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JC283_RS10705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JC283_RS10715	COG1121	(ABC) transporter
JC283_RS10720	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JC283_RS10725	COG0803	Belongs to the bacterial solute-binding protein 9 family
JC283_RS10730	COG1320	monovalent cation:proton antiporter activity
JC283_RS10735	COG2212	antiporter activity
JC283_RS10740	COG1863	multisubunit Na H antiporter MnhE subunit
JC283_RS10750	COG1006	Multisubunit Na H antiporter MnhC subunit
JC283_RS10755	COG2111	Na H antiporter
JC283_RS10760	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JC283_RS10760	COG2111	Na H antiporter
JC283_RS10810	COG0546	phosphoglycolate phosphatase activity
JC283_RS10815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JC283_RS10820	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JC283_RS10825	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JC283_RS10830	COG0805	protein transport
JC283_RS10835	COG0018	arginyl-trna synthetase
JC283_RS10850	COG1078	dGTPase activity
JC283_RS10860	COG4844	belongs to the
JC283_RS10920	COG0471	metal ion transport
JC283_RS10950	COG0095	Lipoate-protein ligase
JC283_RS10955	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JC283_RS10960	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
JC283_RS10970	COG2814	Major facilitator Superfamily
JC283_RS10975	COG1566	PFAM secretion protein HlyD family protein
JC283_RS10985	COG2311	Membrane
JC283_RS11020	COG2363	Small membrane protein
JC283_RS11050	COG0183	Belongs to the thiolase family
JC283_RS11055	COG0318	PFAM AMP-dependent synthetase and ligase
JC283_RS11060	COG0588	phosphoglycerate mutase activity
JC283_RS11065	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JC283_RS11075	COG2814	Major facilitator Superfamily
JC283_RS11085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JC283_RS11095	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
JC283_RS11110	COG1263	PTS System
JC283_RS11110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JC283_RS11110	COG2190	(PTS) system
JC283_RS11125	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JC283_RS11130	COG1469	GTP cyclohydrolase I activity
JC283_RS11180	COG1136	(ABC) transporter
JC283_RS11180	COG0577	efflux transmembrane transporter activity
JC283_RS11195	COG0561	phosphatase activity
JC283_RS11205	COG1428	Deoxynucleoside kinase
JC283_RS11210	COG1428	Deoxynucleoside kinase
JC283_RS11215	COG0546	phosphoglycolate phosphatase activity
JC283_RS11245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JC283_RS11255	COG1473	amidohydrolase
JC283_RS11260	COG3527	Alpha-acetolactate decarboxylase
JC283_RS11265	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JC283_RS11270	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JC283_RS11275	COG0049	tRNA binding
JC283_RS11280	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JC283_RS11290	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JC283_RS11295	COG0085	RNA polymerase activity
JC283_RS11300	COG2813	Specifically methylates the guanine in position
JC283_RS11310	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JC283_RS11315	COG0081	regulation of translation
JC283_RS11320	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JC283_RS11325	COG0250	Participates in transcription elongation, termination and antitermination
JC283_RS11330	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JC283_RS11335	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JC283_RS11355	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
JC283_RS11360	COG0215	cysteine-tRNA ligase activity
JC283_RS11365	COG1045	serine acetyltransferase
JC283_RS11370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JC283_RS11380	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JC283_RS11385	COG4956	integral membrane protein (PIN domain superfamily)
JC283_RS11390	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
JC283_RS11425	COG0542	response to heat
JC283_RS11430	COG3869	Catalyzes the specific phosphorylation of arginine residues in
JC283_RS11435	COG3880	PFAM UvrB UvrC protein
JC283_RS11445	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JC283_RS11455	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
JC283_RS11460	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
JC283_RS11465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JC283_RS11470	COG1289	transmembrane transporter activity
JC283_RS11560	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JC283_RS11565	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JC283_RS11575	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JC283_RS11585	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
JC283_RS11590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JC283_RS11605	COG1098	S1 RNA binding domain
JC283_RS11615	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
JC283_RS11620	COG3956	TIGRFAM MazG family protein
JC283_RS11625	COG2244	polysaccharide biosynthetic process
JC283_RS11630	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JC283_RS11635	COG0193	aminoacyl-tRNA hydrolase activity
JC283_RS11645	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JC283_RS11650	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JC283_RS11655	COG2088	sporulation resulting in formation of a cellular spore
JC283_RS11660	COG0251	oxidation-reduction process
JC283_RS11665	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JC283_RS11670	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JC283_RS11675	COG4466	Protein conserved in bacteria
JC283_RS11685	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
JC283_RS11690	COG0084	hydrolase, TatD family'
JC283_RS11700	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
JC283_RS11705	COG2827	Endonuclease containing a URI domain
JC283_RS11710	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
JC283_RS11715	COG4467	Involved in initiation control of chromosome replication
JC283_RS11720	COG1774	PSP1 C-terminal conserved region
JC283_RS11725	COG0470	DNA polymerase III
JC283_RS11730	COG3870	Protein conserved in bacteria
JC283_RS11735	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JC283_RS11740	COG1982	Orn Lys Arg decarboxylase major
JC283_RS11765	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JC283_RS11770	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JC283_RS11775	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JC283_RS11780	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
JC283_RS11790	COG2188	Transcriptional regulator
JC283_RS11795	COG0366	Alpha amylase catalytic
JC283_RS11800	COG1263	PTS System
JC283_RS11800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JC283_RS11805	COG3344	reverse transcriptase
JC283_RS11815	COG0493	'glutamate synthase
JC283_RS11820	COG0070	glutamate synthase
JC283_RS11820	COG0069	glutamate synthase activity
JC283_RS11820	COG0067	glutamate synthase
JC283_RS11825	COG0583	DNA-binding transcription factor activity
JC283_RS11840	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JC283_RS11870	COG0626	cystathionine gamma-synthase activity
JC283_RS11875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JC283_RS11880	COG2272	Belongs to the type-B carboxylesterase lipase family
JC283_RS11885	COG0733	neurotransmitter:sodium symporter activity
JC283_RS11895	COG0745	RESPONSE REGULATOR receiver
JC283_RS11900	COG2205	protein histidine kinase activity
JC283_RS11910	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
JC283_RS11915	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
JC283_RS11930	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JC283_RS11935	COG0574	Belongs to the PEP-utilizing enzyme family
JC283_RS11935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JC283_RS11965	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
JC283_RS11975	COG1486	melibiose metabolic process
JC283_RS11980	COG1263	PTS System
JC283_RS11980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JC283_RS12000	COG2210	Belongs to the sulfur carrier protein TusA family
JC283_RS12005	COG1937	Protein conserved in bacteria
JC283_RS12010	COG0730	response to heat
JC283_RS12015	COG2814	Major facilitator Superfamily
JC283_RS12035	COG3682	Transcriptional regulator
JC283_RS12060	COG1124	(ABC) transporter
JC283_RS12065	COG0444	Belongs to the ABC transporter superfamily
JC283_RS12070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JC283_RS12075	COG0601	transmembrane transport
JC283_RS12080	COG0747	negative chemotaxis
JC283_RS12105	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
JC283_RS12125	COG1525	nuclease
JC283_RS12160	COG0582	viral genome integration into host DNA
JC283_RS12180	COG1674	ftsk spoiiie
JC283_RS12185	COG2946	Replication initiation factor
JC283_RS12230	COG0791	NLP P60 protein
JC283_RS12230	COG0741	lytic transglycosylase activity
JC283_RS12275	COG0582	viral genome integration into host DNA
JC283_RS12310	COG3617	BRO family, N-terminal domain
JC283_RS12335	COG0582	viral genome integration into host DNA
JC283_RS12340	COG0519	Catalyzes the synthesis of GMP from XMP
JC283_RS12340	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JC283_RS12345	COG0516	GMP reductase activity
JC283_RS12345	COG0517	IMP dehydrogenase activity
JC283_RS12350	COG2233	PERMEase
JC283_RS12355	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JC283_RS12370	COG5183	chlorophyll binding
JC283_RS12375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JC283_RS12380	COG1823	symporter activity
JC283_RS12410	COG0778	Nitroreductase
JC283_RS12415	COG0450	alkyl hydroperoxide reductase
JC283_RS12430	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JC283_RS12440	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JC283_RS12445	COG2011	ABC-type metal ion transport system permease component
JC283_RS12450	COG1464	Belongs to the NlpA lipoprotein family
JC283_RS12455	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JC283_RS12460	COG0753	catalase activity
JC283_RS12470	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JC283_RS12480	COG0360	Binds together with S18 to 16S ribosomal RNA
JC283_RS12490	COG1668	transmembrane transport
JC283_RS12495	COG1131	(ABC) transporter
JC283_RS12500	COG0012	GTP binding
JC283_RS12530	COG0012	GTP binding
JC283_RS12535	COG4481	Protein conserved in bacteria
JC283_RS12540	COG0668	transmembrane transport
JC283_RS12545	COG1475	DNA binding
JC283_RS12550	COG0626	cystathionine gamma-synthase activity
JC283_RS12555	COG0626	cystathionine gamma-synthase activity
JC283_RS12560	COG0646	methionine synthase
JC283_RS12560	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
JC283_RS12570	COG0829	nickel cation binding
JC283_RS12580	COG0830	nickel cation binding
JC283_RS12585	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
JC283_RS12595	COG2388	GCN5-related N-acetyl-transferase
JC283_RS12600	COG1846	Transcriptional regulator
JC283_RS12605	COG0346	lactoylglutathione lyase activity
JC283_RS12610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JC283_RS12615	COG0400	carboxylic ester hydrolase activity
JC283_RS12630	COG0357	Ribosomal RNA small subunit methyltransferase G
JC283_RS12635	COG0445	tRNA wobble uridine modification
JC283_RS12640	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
JC283_RS12645	COG0594	ribonuclease P activity