locus-tag	class	description
IAU63_RS00005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IAU63_RS00015	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IAU63_RS00020	COG2759	Belongs to the formate--tetrahydrofolate ligase family
IAU63_RS00025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IAU63_RS00030	COG0454	-acetyltransferase
IAU63_RS00040	COG1609	Transcriptional regulator
IAU63_RS00045	COG1605	Chorismate mutase
IAU63_RS00045	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IAU63_RS00055	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
IAU63_RS00060	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IAU63_RS00065	COG1674	ftsk spoiiie
IAU63_RS00070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IAU63_RS00075	COG4848	Belongs to the UPF0354 family
IAU63_RS00080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IAU63_RS00085	COG1363	Peptidase, m42
IAU63_RS00095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IAU63_RS00100	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IAU63_RS00105	COG0510	thiamine kinase activity
IAU63_RS00110	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IAU63_RS00115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IAU63_RS00125	COG1187	pseudouridine synthase activity
IAU63_RS00130	COG2244	polysaccharide biosynthetic process
IAU63_RS00135	COG2081	HI0933 family
IAU63_RS00140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IAU63_RS00145	COG0495	leucyl-tRNA aminoacylation
IAU63_RS00150	COG2814	Major facilitator Superfamily
IAU63_RS00155	COG1242	4 iron, 4 sulfur cluster binding
IAU63_RS00160	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
IAU63_RS00170	COG0039	L-malate dehydrogenase activity
IAU63_RS00175	COG2267	carboxylic ester hydrolase activity
IAU63_RS00190	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IAU63_RS00195	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IAU63_RS00195	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IAU63_RS00200	COG0307	riboflavin synthase, alpha
IAU63_RS00205	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IAU63_RS00205	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IAU63_RS00215	COG5632	N-Acetylmuramoyl-L-alanine amidase
IAU63_RS00215	COG4193	domain, Protein
IAU63_RS00215	COG3266	domain, Protein
IAU63_RS00240	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IAU63_RS00250	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IAU63_RS00255	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IAU63_RS00260	COG0656	L-ascorbic acid biosynthetic process
IAU63_RS00275	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IAU63_RS00280	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IAU63_RS00285	COG1506	peptidase
IAU63_RS00290	COG0494	nUDIX hydrolase
IAU63_RS00295	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IAU63_RS00315	COG0235	Class ii aldolase
IAU63_RS00320	COG3623	hexulose-6-phosphate isomerase
IAU63_RS00340	COG3037	sugar-specific permease SgaT UlaA
IAU63_RS00405	COG4824	toxin secretion phage lysis holin
IAU63_RS00660	COG0582	viral genome integration into host DNA
IAU63_RS00710	COG3545	Serine hydrolase
IAU63_RS00715	COG3344	reverse transcriptase
IAU63_RS00720	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IAU63_RS00730	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IAU63_RS00740	COG3344	reverse transcriptase
IAU63_RS00745	COG4473	ABC transporter
IAU63_RS00750	COG1131	(ABC) transporter
IAU63_RS00755	COG0537	adenosine 5'-monophosphoramidase activity
IAU63_RS00765	COG1846	Transcriptional regulator
IAU63_RS00780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IAU63_RS00785	COG3481	metal-dependent phosphohydrolase, HD sub domain
IAU63_RS00795	COG0420	3'-5' exonuclease activity
IAU63_RS00800	COG3679	Belongs to the UPF0342 family
IAU63_RS00805	COG4399	Belongs to the UPF0754 family
IAU63_RS00810	COG3344	reverse transcriptase
IAU63_RS00825	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IAU63_RS00830	COG2197	response regulator
IAU63_RS00835	COG4585	Histidine kinase
IAU63_RS00835	COG2203	Gaf domain
IAU63_RS00840	COG0564	pseudouridine synthase activity
IAU63_RS00845	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IAU63_RS00850	COG0248	Ppx GppA phosphatase
IAU63_RS00855	COG0114	fumarate hydratase activity
IAU63_RS00870	COG0363	glucosamine-6-phosphate deaminase activity
IAU63_RS00880	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IAU63_RS00885	COG1126	abc transporter atp-binding protein
IAU63_RS00890	COG0765	amino acid transport
IAU63_RS01115	COG0735	belongs to the Fur family
IAU63_RS01125	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IAU63_RS01130	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IAU63_RS01135	COG4129	membrane
IAU63_RS01140	COG0069	glutamate synthase activity
IAU63_RS01150	COG3557	Belongs to the UPF0374 family
IAU63_RS01155	COG1194	a g-specific adenine glycosylase
IAU63_RS01160	COG1988	membrane-bound metal-dependent
IAU63_RS01170	COG1134	teichoic acid transport
IAU63_RS01170	COG1388	LysM domain
IAU63_RS01180	COG2137	regulation of response to DNA damage stimulus
IAU63_RS01185	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IAU63_RS01190	COG0028	Belongs to the TPP enzyme family
IAU63_RS01195	COG0693	protein deglycase activity
IAU63_RS01205	COG0535	radical SAM domain protein
IAU63_RS01210	COG1607	acyl-coa hydrolase
IAU63_RS01215	COG2309	aminopeptidase activity
IAU63_RS01220	COG4840	Belongs to the UPF0435 family
IAU63_RS01235	COG1295	ribonuclease BN
IAU63_RS01240	COG0288	reversible hydration of carbon dioxide
IAU63_RS01265	COG0024	Methionine aminopeptidase
IAU63_RS01270	COG4129	membrane
IAU63_RS01285	COG1528	Iron-storage protein
IAU63_RS01295	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IAU63_RS01320	COG1597	lipid kinase activity
IAU63_RS01325	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IAU63_RS01335	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IAU63_RS01340	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IAU63_RS01345	COG4851	CamS sex pheromone cAM373 precursor
IAU63_RS01350	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IAU63_RS01355	COG0210	DNA helicase
IAU63_RS01360	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
IAU63_RS01365	COG4496	protein, YerC YecD
IAU63_RS01370	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IAU63_RS01380	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
IAU63_RS01390	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IAU63_RS01400	COG0077	Prephenate dehydratase
IAU63_RS01400	COG1605	Chorismate mutase
IAU63_RS01410	COG1335	isochorismatase
IAU63_RS01415	COG1227	inorganic diphosphatase activity
IAU63_RS01425	COG1012	belongs to the aldehyde dehydrogenase family
IAU63_RS01430	COG2706	6-phosphogluconolactonase activity
IAU63_RS01465	COG2610	gluconate transmembrane transporter activity
IAU63_RS01470	COG1070	Carbohydrate kinase
IAU63_RS01475	COG1802	Transcriptional regulator
IAU63_RS01485	COG1131	(ABC) transporter
IAU63_RS01505	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IAU63_RS01510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IAU63_RS01515	COG1404	Belongs to the peptidase S8 family
IAU63_RS01560	COG4512	PFAM Accessory gene regulator B
IAU63_RS01580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IAU63_RS01585	COG1621	beta-fructofuranosidase activity
IAU63_RS01590	COG1609	Transcriptional regulator
IAU63_RS01595	COG2124	cytochrome p450
IAU63_RS01605	COG1846	Transcriptional regulator
IAU63_RS01610	COG2814	Major facilitator Superfamily
IAU63_RS01615	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
IAU63_RS01620	COG0488	(ABC) transporter
IAU63_RS01625	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IAU63_RS01635	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IAU63_RS01640	COG0456	acetyltransferase
IAU63_RS01645	COG1214	PFAM Peptidase M22, glycoprotease
IAU63_RS01650	COG0802	atpase or kinase
IAU63_RS01655	COG0129	dihydroxy-acid dehydratase activity
IAU63_RS01660	COG0028	Belongs to the TPP enzyme family
IAU63_RS01670	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IAU63_RS01675	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IAU63_RS01685	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IAU63_RS01730	COG3091	SprT-like family
IAU63_RS01735	COG2183	response to ionizing radiation
IAU63_RS01740	COG1191	sigma factor activity
IAU63_RS01750	COG1366	Belongs to the anti-sigma-factor antagonist family
IAU63_RS01755	COG2208	phosphoserine phosphatase activity
IAU63_RS01760	COG2337	Toxic component of a toxin-antitoxin (TA) module
IAU63_RS01770	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IAU63_RS01775	COG0736	holo-[acyl-carrier-protein] synthase activity
IAU63_RS01780	COG3402	PFAM membrane-flanked domain
IAU63_RS01795	COG0513	Belongs to the DEAD box helicase family
IAU63_RS01800	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IAU63_RS01805	COG1181	Belongs to the D-alanine--D-alanine ligase family
IAU63_RS01810	COG0772	Belongs to the SEDS family
IAU63_RS01825	COG2217	Heavy metal translocating P-type atpase
IAU63_RS01840	COG1937	Protein conserved in bacteria
IAU63_RS01845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IAU63_RS01850	COG1418	mRNA catabolic process
IAU63_RS01855	COG0706	membrane insertase activity
IAU63_RS01860	COG0352	thiamine-phosphate diphosphorylase activity
IAU63_RS01865	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
IAU63_RS01875	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IAU63_RS01890	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IAU63_RS01920	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IAU63_RS01930	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IAU63_RS01940	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IAU63_RS01945	COG0356	it plays a direct role in the translocation of protons across the membrane
IAU63_RS01955	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IAU63_RS01960	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IAU63_RS01965	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IAU63_RS01970	COG4475	Protein of unknown function (DUF436)
IAU63_RS01975	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IAU63_RS01980	COG0009	L-threonylcarbamoyladenylate synthase
IAU63_RS01985	COG2890	protein-(glutamine-N5) methyltransferase activity
IAU63_RS01990	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IAU63_RS02000	COG0254	rRNA binding
IAU63_RS02005	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IAU63_RS02015	COG1733	regulation of RNA biosynthetic process
IAU63_RS02020	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IAU63_RS02025	COG0191	fructose-bisphosphate aldolase activity
IAU63_RS02030	COG4821	SIS domain
IAU63_RS02035	COG2271	Major facilitator Superfamily
IAU63_RS02040	COG0504	CTP synthase activity
IAU63_RS02050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IAU63_RS02065	COG5146	pantothenate kinase activity
IAU63_RS02100	COG0813	purine-nucleoside phosphorylase activity
IAU63_RS02110	COG1757	Na H antiporter
IAU63_RS02125	COG1482	cell wall glycoprotein biosynthetic process
IAU63_RS02130	COG2186	Transcriptional regulator
IAU63_RS02140	COG0561	phosphatase activity
IAU63_RS02145	COG1119	ATPase activity
IAU63_RS02175	COG3711	transcriptional antiterminator
IAU63_RS02190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IAU63_RS02255	COG0489	protein tyrosine kinase activity
IAU63_RS02260	COG2814	Major facilitator Superfamily
IAU63_RS02280	COG1272	protein, Hemolysin III
IAU63_RS02285	COG4284	Utp--glucose-1-phosphate uridylyltransferase
IAU63_RS02290	COG1988	membrane-bound metal-dependent
IAU63_RS02300	COG3314	Sporulation integral membrane protein YlbJ
IAU63_RS02305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAU63_RS02310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAU63_RS02315	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
IAU63_RS02320	COG3457	Alanine racemase
IAU63_RS02325	COG4264	IucA IucC family
IAU63_RS02330	COG2814	Major facilitator Superfamily
IAU63_RS02335	COG4264	IucA IucC family
IAU63_RS02340	COG2814	Major facilitator Superfamily
IAU63_RS02345	COG1302	Protein conserved in bacteria
IAU63_RS02360	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IAU63_RS02370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAU63_RS02375	COG0488	(ABC) transporter
IAU63_RS02385	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IAU63_RS02385	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IAU63_RS02395	COG3684	Belongs to the aldolase LacD family
IAU63_RS02410	COG1349	DNA-binding transcription factor activity
IAU63_RS02415	COG1335	isochorismatase
IAU63_RS02430	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IAU63_RS02435	COG0101	tRNA pseudouridine synthase activity
IAU63_RS02445	COG1122	ATPase activity
IAU63_RS02450	COG1122	ATPase activity
IAU63_RS02455	COG0203	ribosomal protein L17
IAU63_RS02460	COG0202	RNA polymerase activity
IAU63_RS02465	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IAU63_RS02475	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IAU63_RS02490	COG0201	protein transport
IAU63_RS02500	COG1841	ribosomal large subunit assembly
IAU63_RS02505	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IAU63_RS02515	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IAU63_RS02520	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IAU63_RS02525	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IAU63_RS02540	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IAU63_RS02550	COG0255	Belongs to the universal ribosomal protein uL29 family
IAU63_RS02555	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IAU63_RS02560	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IAU63_RS02565	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IAU63_RS02570	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IAU63_RS02575	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IAU63_RS02580	COG0089	rRNA binding
IAU63_RS02585	COG0088	Forms part of the polypeptide exit tunnel
IAU63_RS02590	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IAU63_RS02610	COG2252	PERMEase
IAU63_RS02640	COG0436	Aminotransferase
IAU63_RS02645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IAU63_RS02650	COG2348	transferase activity, transferring amino-acyl groups
IAU63_RS02675	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IAU63_RS02680	COG0746	molybdenum cofactor guanylyltransferase activity
IAU63_RS02690	COG0314	molybdopterin synthase activity
IAU63_RS02710	COG0521	Mo-molybdopterin cofactor biosynthetic process
IAU63_RS02715	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IAU63_RS02720	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IAU63_RS02725	COG4149	molybdate abc transporter
IAU63_RS02735	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
IAU63_RS02740	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IAU63_RS02745	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IAU63_RS02750	COG1609	Transcriptional regulator
IAU63_RS02765	COG1268	BioY protein
IAU63_RS02775	COG2186	Transcriptional regulator
IAU63_RS02785	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IAU63_RS02790	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
IAU63_RS02795	COG2832	Protein of unknown function (DUF454)
IAU63_RS02800	COG1960	acyl-CoA dehydrogenase activity
IAU63_RS02820	COG3942	CHAP domain
IAU63_RS02830	COG1757	Na H antiporter
IAU63_RS02840	COG3942	CHAP domain
IAU63_RS02845	COG2076	Multidrug Resistance protein
IAU63_RS02850	COG2076	Multidrug Resistance protein
IAU63_RS02855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IAU63_RS02880	COG3383	formate dehydrogenase (NAD+) activity
IAU63_RS02885	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
IAU63_RS02900	COG1316	TRANSCRIPTIONal
IAU63_RS02925	COG1113	amino acid transport
IAU63_RS02950	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IAU63_RS02955	COG0346	lactoylglutathione lyase activity
IAU63_RS02965	COG0385	Bile acid
IAU63_RS02985	COG1473	amidohydrolase
IAU63_RS02990	COG0659	secondary active sulfate transmembrane transporter activity
IAU63_RS02995	COG1228	amidohydrolase
IAU63_RS03000	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IAU63_RS03005	COG3314	Sporulation integral membrane protein YlbJ
IAU63_RS03010	COG0583	DNA-binding transcription factor activity
IAU63_RS03015	COG1266	CAAX protease self-immunity
IAU63_RS03025	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IAU63_RS03030	COG2258	MOSC domain
IAU63_RS03035	COG2017	converts alpha-aldose to the beta-anomer
IAU63_RS03040	COG1742	UPF0060 membrane protein
IAU63_RS03045	COG1668	transmembrane transport
IAU63_RS03050	COG4152	abc transporter atp-binding protein
IAU63_RS03055	COG3152	Membrane
IAU63_RS03060	COG2094	Belongs to the DNA glycosylase MPG family
IAU63_RS03065	COG1757	Na H antiporter
IAU63_RS03085	COG3250	beta-galactosidase activity
IAU63_RS03090	COG2207	Transcriptional regulator
IAU63_RS03095	COG0786	glutamate:sodium symporter activity
IAU63_RS03100	COG0523	cobalamin synthesis protein
IAU63_RS03105	COG1304	FMN binding
IAU63_RS03125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IAU63_RS03135	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IAU63_RS03145	COG4640	response to antibiotic
IAU63_RS03170	COG0577	efflux transmembrane transporter activity
IAU63_RS03185	COG0579	oxidoreductase
IAU63_RS03190	COG0438	transferase activity, transferring glycosyl groups
IAU63_RS03195	COG1620	l-lactate permease
IAU63_RS03210	COG0604	alcohol dehydrogenase
IAU63_RS03215	COG2814	Major facilitator Superfamily
IAU63_RS03220	COG0492	ferredoxin-NADP+ reductase activity
IAU63_RS03240	COG1283	sodium-dependent phosphate transmembrane transporter activity
IAU63_RS03255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IAU63_RS03255	COG1263	PTS System
IAU63_RS03265	COG2807	transmembrane transport
IAU63_RS03275	COG0697	spore germination
IAU63_RS03280	COG1363	Peptidase, m42
IAU63_RS03285	COG0039	L-malate dehydrogenase activity
IAU63_RS03295	COG4187	Peptidase family M20/M25/M40
IAU63_RS03300	COG3344	reverse transcriptase
IAU63_RS03305	COG2223	nitrite transmembrane transporter activity
IAU63_RS03310	COG2197	response regulator
IAU63_RS03315	COG4585	Histidine kinase
IAU63_RS03325	COG2181	nitrate reductase activity
IAU63_RS03335	COG1140	nitrate reductase beta subunit
IAU63_RS03340	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IAU63_RS03350	COG0737	Belongs to the 5'-nucleotidase family
IAU63_RS03355	COG1648	precorrin-2 dehydrogenase activity
IAU63_RS03355	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IAU63_RS03360	COG2146	nitrite reductase [NAD(P)H] activity
IAU63_RS03365	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IAU63_RS03370	COG1648	precorrin-2 dehydrogenase activity
IAU63_RS03370	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IAU63_RS03380	COG0454	-acetyltransferase
IAU63_RS03385	COG2116	formate transmembrane transporter activity
IAU63_RS03390	COG0471	metal ion transport
IAU63_RS03420	COG1760	l-serine dehydratase
IAU63_RS03425	COG1760	l-serine dehydratase
IAU63_RS03435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAU63_RS03440	COG0601	transmembrane transport
IAU63_RS03445	COG4608	Belongs to the ABC transporter superfamily
IAU63_RS03450	COG0444	Belongs to the ABC transporter superfamily
IAU63_RS03455	COG4166	transmembrane transport
IAU63_RS03460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAU63_RS03465	COG0601	transmembrane transport
IAU63_RS03470	COG4608	Belongs to the ABC transporter superfamily
IAU63_RS03475	COG0444	Belongs to the ABC transporter superfamily
IAU63_RS03480	COG4166	transmembrane transport
IAU63_RS03485	COG0702	epimerase
IAU63_RS03490	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IAU63_RS03510	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
IAU63_RS03520	COG1929	Belongs to the glycerate kinase type-1 family
IAU63_RS03525	COG3764	Sortase (surface protein transpeptidase)
IAU63_RS03530	COG2271	Major facilitator Superfamily
IAU63_RS03535	COG2814	Major facilitator Superfamily
IAU63_RS03540	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
IAU63_RS03545	COG1115	amino acid carrier protein
IAU63_RS03550	COG3871	stress protein (general stress protein 26)
IAU63_RS03610	COG0741	lytic transglycosylase activity
IAU63_RS03610	COG0791	NLP P60 protein
IAU63_RS03640	COG2946	Replication initiation factor
IAU63_RS03650	COG1674	ftsk spoiiie
IAU63_RS03670	COG1132	(ABC) transporter
IAU63_RS03675	COG1132	(ABC) transporter
IAU63_RS03680	COG0247	lactate metabolic process
IAU63_RS03685	COG0277	FAD linked oxidase domain protein
IAU63_RS03705	COG0159	tryptophan synthase activity
IAU63_RS03710	COG0133	tryptophan synthase activity
IAU63_RS03720	COG0134	indole-3-glycerol-phosphate synthase activity
IAU63_RS03730	COG0512	Glutamine amidotransferase of anthranilate synthase
IAU63_RS03735	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IAU63_RS03740	COG3961	Belongs to the TPP enzyme family
IAU63_RS03745	COG2855	membrane
IAU63_RS03750	COG3835	regulator
IAU63_RS03765	COG1028	Short-chain dehydrogenase reductase Sdr
IAU63_RS03805	COG2357	RelA SpoT domain protein
IAU63_RS03810	COG0778	Nitroreductase
IAU63_RS03815	COG1846	Transcriptional regulator
IAU63_RS03830	COG1346	cytolysis
IAU63_RS03840	COG0583	DNA-binding transcription factor activity
IAU63_RS03865	COG1141	Ferredoxin
IAU63_RS03875	COG0523	cobalamin synthesis protein
IAU63_RS03880	COG0717	Belongs to the dCTP deaminase family
IAU63_RS03885	COG0804	urea catabolic process
IAU63_RS03890	COG0832	Belongs to the urease beta subunit family
IAU63_RS03900	COG4413	Urea transporter
IAU63_RS03920	COG0577	efflux transmembrane transporter activity
IAU63_RS03925	COG1136	(ABC) transporter
IAU63_RS03950	COG3001	Fructosamine kinase
IAU63_RS03955	COG0778	Nitroreductase
IAU63_RS03960	COG3181	Tripartite tricarboxylate transporter family receptor
IAU63_RS03980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IAU63_RS03985	COG0438	transferase activity, transferring glycosyl groups
IAU63_RS03990	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IAU63_RS03990	COG0463	Glycosyl transferase, family 2
IAU63_RS03995	COG0463	Glycosyl transferase, family 2
IAU63_RS03995	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IAU63_RS04020	COG0747	negative chemotaxis
IAU63_RS04025	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IAU63_RS04030	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IAU63_RS04045	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IAU63_RS04055	COG1705	Flagellar rod assembly protein muramidase FlgJ
IAU63_RS04055	COG3942	CHAP domain
IAU63_RS04065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IAU63_RS04065	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IAU63_RS04065	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IAU63_RS04070	COG0789	Transcriptional regulator
IAU63_RS04075	COG0596	Alpha beta hydrolase
IAU63_RS04090	COG1012	belongs to the aldehyde dehydrogenase family
IAU63_RS04095	COG2824	Alkylphosphonate utilization operon protein PhnA
IAU63_RS04100	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
IAU63_RS04105	COG1461	Dihydroxyacetone kinase
IAU63_RS04110	COG2376	Dihydroxyacetone kinase
IAU63_RS04145	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
IAU63_RS04150	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IAU63_RS04155	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IAU63_RS04160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IAU63_RS04175	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IAU63_RS04180	COG0107	imidazoleglycerol-phosphate synthase activity
IAU63_RS04190	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IAU63_RS04195	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IAU63_RS04200	COG1012	belongs to the aldehyde dehydrogenase family
IAU63_RS04205	COG1510	regulation of RNA biosynthetic process
IAU63_RS04215	COG1914	H( )-stimulated, divalent metal cation uptake system
IAU63_RS04245	COG1785	Belongs to the alkaline phosphatase family
IAU63_RS04260	COG1396	sequence-specific DNA binding
IAU63_RS04265	COG2807	transmembrane transport
IAU63_RS04270	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
IAU63_RS04275	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IAU63_RS04315	COG1957	nucleoside hydrolase
IAU63_RS04320	COG3250	beta-galactosidase activity
IAU63_RS04325	COG2211	Major facilitator Superfamily
IAU63_RS04330	COG0477	Major facilitator Superfamily
IAU63_RS04335	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IAU63_RS04340	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IAU63_RS04350	COG2972	Histidine kinase
IAU63_RS04355	COG2207	Transcriptional regulator
IAU63_RS04355	COG4753	response regulator
IAU63_RS04380	COG3443	Belongs to the bacterial solute-binding protein 9 family
IAU63_RS04380	COG0803	Belongs to the bacterial solute-binding protein 9 family
IAU63_RS04390	COG1942	4-Oxalocrotonate Tautomerase
IAU63_RS04395	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IAU63_RS04415	COG1328	CTP reductase activity
IAU63_RS04425	COG3037	sugar-specific permease SgaT UlaA
IAU63_RS04435	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IAU63_RS04440	COG3711	transcriptional antiterminator
IAU63_RS04465	COG1869	D-ribose catabolic process
IAU63_RS04470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IAU63_RS04475	COG1609	Transcriptional regulator
IAU63_RS04505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IAU63_RS04515	COG2814	Major facilitator Superfamily
IAU63_RS04525	COG0318	PFAM AMP-dependent synthetase and ligase
IAU63_RS04540	COG0183	Belongs to the thiolase family
IAU63_RS04545	COG0438	transferase activity, transferring glycosyl groups
IAU63_RS04565	COG1073	alpha beta
IAU63_RS04600	COG0579	oxidoreductase
IAU63_RS04625	COG1755	Isoprenylcysteine carboxyl methyltransferase
IAU63_RS04635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IAU63_RS04645	COG1136	(ABC) transporter
IAU63_RS04670	COG0436	Aminotransferase
IAU63_RS04680	COG0783	Belongs to the Dps family
IAU63_RS04690	COG0753	catalase activity
IAU63_RS04695	COG2318	DinB family
IAU63_RS04710	COG0076	glutamate decarboxylase activity
IAU63_RS04725	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IAU63_RS04770	COG0156	8-amino-7-oxononanoate synthase activity
IAU63_RS04775	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IAU63_RS04780	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IAU63_RS04785	COG1620	l-lactate permease
IAU63_RS04800	COG1063	alcohol dehydrogenase
IAU63_RS04820	COG3314	Sporulation integral membrane protein YlbJ
IAU63_RS04840	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IAU63_RS04850	COG3716	PTS system mannose fructose sorbose family IID component
IAU63_RS04855	COG3715	PTS system
IAU63_RS04860	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IAU63_RS04860	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IAU63_RS04875	COG1105	Belongs to the carbohydrate kinase PfkB family
IAU63_RS04880	COG2222	sugar isomerase
IAU63_RS04885	COG2188	Transcriptional regulator
IAU63_RS04890	COG0366	Alpha amylase catalytic
IAU63_RS04900	COG1131	(ABC) transporter
IAU63_RS04935	COG0346	lactoylglutathione lyase activity
IAU63_RS04945	COG0490	domain, Protein
IAU63_RS04950	COG0475	glutathione-regulated potassium exporter activity
IAU63_RS04955	COG3842	ATPase activity
IAU63_RS04965	COG1175	transmembrane transport
IAU63_RS04970	COG3833	ABC-type maltose transport systems, permease component
IAU63_RS04980	COG0366	Alpha amylase catalytic
IAU63_RS04990	COG0673	inositol 2-dehydrogenase activity
IAU63_RS05000	COG1609	Transcriptional regulator
IAU63_RS05045	COG0431	NADPH-dependent FMN reductase
IAU63_RS05065	COG1131	(ABC) transporter
IAU63_RS05070	COG0842	Transport permease protein
IAU63_RS05075	COG2203	Gaf domain
IAU63_RS05075	COG4585	Histidine kinase
IAU63_RS05080	COG2197	response regulator
IAU63_RS05095	COG2235	arginine
IAU63_RS05115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IAU63_RS05120	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IAU63_RS05130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IAU63_RS05150	COG2130	NADP-dependent
IAU63_RS05155	COG0702	epimerase
IAU63_RS05170	COG0415	Belongs to the DNA photolyase family
IAU63_RS05180	COG2723	6-phospho-beta-galactosidase activity
IAU63_RS05185	COG2188	Transcriptional regulator
IAU63_RS05195	COG2217	Heavy metal translocating P-type atpase
IAU63_RS05200	COG0531	amino acid
IAU63_RS05220	COG2311	Membrane
IAU63_RS05255	COG1332	CRISPR-associated RAMP protein, Csm5 family
IAU63_RS05260	COG1567	CRISPR-associated RAMP protein, Csm4 family
IAU63_RS05265	COG1337	RAMP superfamily
IAU63_RS05270	COG1421	Csm2 Type III-A
IAU63_RS05275	COG1353	crispr-associated protein
IAU63_RS05280	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IAU63_RS05320	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IAU63_RS05370	COG2030	dehydratase
IAU63_RS05375	COG0584	glycerophosphoryl diester phosphodiesterase
IAU63_RS05420	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IAU63_RS05420	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IAU63_RS05445	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IAU63_RS05455	COG4863	YycH protein
IAU63_RS05460	COG5002	protein histidine kinase activity
IAU63_RS05465	COG0745	RESPONSE REGULATOR receiver
IAU63_RS05485	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IAU63_RS05490	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IAU63_RS05495	COG0305	Participates in initiation and elongation during chromosome replication
IAU63_RS05500	COG0359	binds to the 23S rRNA
IAU63_RS05505	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
IAU63_RS05510	COG4241	membrane
IAU63_RS05515	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IAU63_RS05525	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IAU63_RS05535	COG2986	histidine ammonia-lyase
IAU63_RS05540	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IAU63_RS05550	COG0187	DNA topoisomerase II activity
IAU63_RS05555	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IAU63_RS05560	COG2501	S4 domain
IAU63_RS05570	COG0592	DNA-directed DNA polymerase activity
IAU63_RS05575	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IAU63_RS05585	COG0594	ribonuclease P activity
IAU63_RS05590	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IAU63_RS05595	COG0445	tRNA wobble uridine modification
IAU63_RS05600	COG0357	Ribosomal RNA small subunit methyltransferase G
IAU63_RS05625	COG0400	carboxylic ester hydrolase activity
IAU63_RS05630	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IAU63_RS05635	COG0346	lactoylglutathione lyase activity
IAU63_RS05640	COG1846	Transcriptional regulator
IAU63_RS05645	COG2388	GCN5-related N-acetyl-transferase
IAU63_RS05655	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
IAU63_RS05660	COG0830	nickel cation binding
IAU63_RS05670	COG0829	nickel cation binding
IAU63_RS05680	COG0646	methionine synthase
IAU63_RS05680	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IAU63_RS05685	COG0626	cystathionine gamma-synthase activity
IAU63_RS05690	COG0626	cystathionine gamma-synthase activity
IAU63_RS05695	COG1475	DNA binding
IAU63_RS05700	COG0668	transmembrane transport
IAU63_RS05705	COG4481	Protein conserved in bacteria
IAU63_RS05710	COG0012	GTP binding
IAU63_RS05715	COG1131	(ABC) transporter
IAU63_RS05720	COG1668	transmembrane transport
IAU63_RS05730	COG0360	Binds together with S18 to 16S ribosomal RNA
IAU63_RS05740	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IAU63_RS05750	COG0753	catalase activity
IAU63_RS05755	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IAU63_RS05760	COG1464	Belongs to the NlpA lipoprotein family
IAU63_RS05765	COG2011	ABC-type metal ion transport system permease component
IAU63_RS05770	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IAU63_RS05780	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IAU63_RS05795	COG0450	alkyl hydroperoxide reductase
IAU63_RS05800	COG0778	Nitroreductase
IAU63_RS05830	COG1823	symporter activity
IAU63_RS05835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IAU63_RS05840	COG5183	chlorophyll binding
IAU63_RS05855	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IAU63_RS05860	COG2233	PERMEase
IAU63_RS05865	COG0516	GMP reductase activity
IAU63_RS05865	COG0517	IMP dehydrogenase activity
IAU63_RS05870	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IAU63_RS05870	COG0519	Catalyzes the synthesis of GMP from XMP
IAU63_RS05900	COG1525	nuclease
IAU63_RS05920	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IAU63_RS05945	COG0747	negative chemotaxis
IAU63_RS05950	COG0601	transmembrane transport
IAU63_RS05955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAU63_RS05960	COG0444	Belongs to the ABC transporter superfamily
IAU63_RS05965	COG1124	(ABC) transporter
IAU63_RS05990	COG3682	Transcriptional regulator
IAU63_RS06005	COG3344	reverse transcriptase
IAU63_RS06015	COG2814	Major facilitator Superfamily
IAU63_RS06020	COG0730	response to heat
IAU63_RS06025	COG1937	Protein conserved in bacteria
IAU63_RS06030	COG2210	Belongs to the sulfur carrier protein TusA family
IAU63_RS06050	COG1263	PTS System
IAU63_RS06050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IAU63_RS06055	COG1486	melibiose metabolic process
IAU63_RS06065	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IAU63_RS06110	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IAU63_RS06110	COG0574	Belongs to the PEP-utilizing enzyme family
IAU63_RS06115	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IAU63_RS06130	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IAU63_RS06135	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IAU63_RS06145	COG2205	protein histidine kinase activity
IAU63_RS06150	COG0745	RESPONSE REGULATOR receiver
IAU63_RS06160	COG0733	neurotransmitter:sodium symporter activity
IAU63_RS06165	COG2272	Belongs to the type-B carboxylesterase lipase family
IAU63_RS06170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IAU63_RS06175	COG0626	cystathionine gamma-synthase activity
IAU63_RS06200	COG1192	Involved in chromosome partitioning
IAU63_RS06220	COG2226	methyltransferase
IAU63_RS06230	COG0456	acetyltransferase
IAU63_RS06240	COG2378	regulation of single-species biofilm formation
IAU63_RS06245	COG1192	Involved in chromosome partitioning
IAU63_RS06325	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IAU63_RS06365	COG1131	(ABC) transporter
IAU63_RS06375	COG0535	radical SAM domain protein
IAU63_RS06385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IAU63_RS06400	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IAU63_RS06415	COG0583	DNA-binding transcription factor activity
IAU63_RS06420	COG0067	glutamate synthase
IAU63_RS06420	COG0069	glutamate synthase activity
IAU63_RS06420	COG0070	glutamate synthase
IAU63_RS06425	COG0493	'glutamate synthase
IAU63_RS06435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IAU63_RS06435	COG1263	PTS System
IAU63_RS06440	COG0366	Alpha amylase catalytic
IAU63_RS06445	COG2188	Transcriptional regulator
IAU63_RS06455	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IAU63_RS06460	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IAU63_RS06465	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IAU63_RS06470	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IAU63_RS06495	COG1982	Orn Lys Arg decarboxylase major
IAU63_RS06500	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IAU63_RS06505	COG3870	Protein conserved in bacteria
IAU63_RS06510	COG0470	DNA polymerase III
IAU63_RS06515	COG1774	PSP1 C-terminal conserved region
IAU63_RS06520	COG4467	Involved in initiation control of chromosome replication
IAU63_RS06525	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IAU63_RS06530	COG2827	Endonuclease containing a URI domain
IAU63_RS06535	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IAU63_RS06545	COG0084	hydrolase, TatD family'
IAU63_RS06550	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
IAU63_RS06560	COG4466	Protein conserved in bacteria
IAU63_RS06565	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IAU63_RS06570	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IAU63_RS06575	COG0251	oxidation-reduction process
IAU63_RS06580	COG2088	sporulation resulting in formation of a cellular spore
IAU63_RS06585	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IAU63_RS06590	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IAU63_RS06600	COG0193	aminoacyl-tRNA hydrolase activity
IAU63_RS06605	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IAU63_RS06610	COG2244	polysaccharide biosynthetic process
IAU63_RS06615	COG3956	TIGRFAM MazG family protein
IAU63_RS06620	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IAU63_RS06630	COG1098	S1 RNA binding domain
IAU63_RS06645	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IAU63_RS06650	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IAU63_RS06660	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IAU63_RS06670	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IAU63_RS06675	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IAU63_RS06770	COG1289	transmembrane transporter activity
IAU63_RS06775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IAU63_RS06780	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
IAU63_RS06785	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
IAU63_RS06795	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IAU63_RS06805	COG3880	PFAM UvrB UvrC protein
IAU63_RS06810	COG3869	Catalyzes the specific phosphorylation of arginine residues in
IAU63_RS06815	COG0542	response to heat
IAU63_RS06850	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IAU63_RS06855	COG4956	integral membrane protein (PIN domain superfamily)
IAU63_RS06860	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IAU63_RS06870	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IAU63_RS06875	COG1045	serine acetyltransferase
IAU63_RS06880	COG0215	cysteine-tRNA ligase activity
IAU63_RS06885	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
IAU63_RS06905	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IAU63_RS06910	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IAU63_RS06915	COG0250	Participates in transcription elongation, termination and antitermination
IAU63_RS06920	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IAU63_RS06925	COG0081	regulation of translation
IAU63_RS06930	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IAU63_RS06940	COG2813	Specifically methylates the guanine in position
IAU63_RS06945	COG0085	RNA polymerase activity
IAU63_RS06950	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IAU63_RS06960	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IAU63_RS06965	COG0049	tRNA binding
IAU63_RS06970	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IAU63_RS06975	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IAU63_RS06980	COG3527	Alpha-acetolactate decarboxylase
IAU63_RS06985	COG1473	amidohydrolase
IAU63_RS06995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IAU63_RS07025	COG0546	phosphoglycolate phosphatase activity
IAU63_RS07030	COG1428	Deoxynucleoside kinase
IAU63_RS07035	COG1428	Deoxynucleoside kinase
IAU63_RS07045	COG0561	phosphatase activity
IAU63_RS07070	COG1469	GTP cyclohydrolase I activity
IAU63_RS07075	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IAU63_RS07090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IAU63_RS07090	COG1263	PTS System
IAU63_RS07090	COG2190	(PTS) system
IAU63_RS07105	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
IAU63_RS07115	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IAU63_RS07135	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IAU63_RS07165	COG0535	radical SAM domain protein
IAU63_RS07170	COG1994	Peptidase M50
IAU63_RS07175	COG1131	(ABC) transporter
IAU63_RS07200	COG0588	phosphoglycerate mutase activity
IAU63_RS07205	COG0318	PFAM AMP-dependent synthetase and ligase
IAU63_RS07210	COG0183	Belongs to the thiolase family
IAU63_RS07240	COG2363	Small membrane protein
IAU63_RS07265	COG1566	PFAM secretion protein HlyD family protein
IAU63_RS07280	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IAU63_RS07285	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IAU63_RS07310	COG0095	Lipoate-protein ligase
IAU63_RS07315	COG0280	phosphate acetyltransferase
IAU63_RS07345	COG0471	metal ion transport
IAU63_RS07415	COG3682	Transcriptional regulator
IAU63_RS07450	COG4844	belongs to the
IAU63_RS07460	COG1078	dGTPase activity
IAU63_RS07475	COG0018	arginyl-trna synthetase
IAU63_RS07480	COG0805	protein transport
IAU63_RS07485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IAU63_RS07490	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IAU63_RS07495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAU63_RS07500	COG0546	phosphoglycolate phosphatase activity
IAU63_RS07550	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IAU63_RS07550	COG2111	Na H antiporter
IAU63_RS07555	COG2111	Na H antiporter
IAU63_RS07560	COG1006	Multisubunit Na H antiporter MnhC subunit
IAU63_RS07570	COG1863	multisubunit Na H antiporter MnhE subunit
IAU63_RS07575	COG2212	antiporter activity
IAU63_RS07580	COG1320	monovalent cation:proton antiporter activity
IAU63_RS07585	COG0803	Belongs to the bacterial solute-binding protein 9 family
IAU63_RS07590	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IAU63_RS07595	COG1121	(ABC) transporter
IAU63_RS07605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAU63_RS07610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAU63_RS07615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IAU63_RS07625	COG2423	ornithine cyclodeaminase activity
IAU63_RS07630	COG4264	IucA IucC family
IAU63_RS07635	COG2814	Major facilitator Superfamily
IAU63_RS07640	COG4264	IucA IucC family
IAU63_RS07645	COG4264	IucA IucC family
IAU63_RS07655	COG0019	diaminopimelate decarboxylase activity
IAU63_RS07660	COG1475	DNA binding
IAU63_RS07670	COG0110	maltose O-acetyltransferase activity
IAU63_RS07675	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
IAU63_RS07685	COG1682	transport, permease protein
IAU63_RS07690	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IAU63_RS07695	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IAU63_RS07710	COG1686	Belongs to the peptidase S11 family
IAU63_RS07715	COG1132	(ABC) transporter
IAU63_RS07735	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IAU63_RS07740	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IAU63_RS07745	COG1120	ATPase activity
IAU63_RS07750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAU63_RS07755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAU63_RS07765	COG0477	Major facilitator Superfamily
IAU63_RS07770	COG3949	Membrane
IAU63_RS07780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IAU63_RS07785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IAU63_RS07790	COG0745	RESPONSE REGULATOR receiver
IAU63_RS07800	COG1136	(ABC) transporter
IAU63_RS07805	COG0577	efflux transmembrane transporter activity
IAU63_RS07810	COG1392	Phosphate transport regulator
IAU63_RS07815	COG0306	phosphate transporter
IAU63_RS07820	COG1388	LysM domain
IAU63_RS07820	COG3942	CHAP domain
IAU63_RS07830	COG0352	thiamine-phosphate diphosphorylase activity
IAU63_RS07840	COG2022	thiamine diphosphate biosynthetic process
IAU63_RS07845	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IAU63_RS07850	COG0217	transcriptional regulatory protein
IAU63_RS07865	COG0583	DNA-binding transcription factor activity
IAU63_RS07870	COG2814	Major facilitator Superfamily
IAU63_RS07875	COG2839	Protein conserved in bacteria
IAU63_RS07905	COG1611	Belongs to the LOG family
IAU63_RS07910	COG1671	Belongs to the UPF0178 family
IAU63_RS07920	COG1968	undecaprenyl-diphosphatase activity
IAU63_RS07925	COG4988	ABC transporter
IAU63_RS07930	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IAU63_RS07940	COG0523	cobalamin synthesis protein
IAU63_RS07945	COG4989	oxidoreductase activity
IAU63_RS07965	COG0039	L-malate dehydrogenase activity
IAU63_RS07985	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IAU63_RS07990	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IAU63_RS08010	COG1349	DNA-binding transcription factor activity
IAU63_RS08015	COG1105	Belongs to the carbohydrate kinase PfkB family
IAU63_RS08020	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IAU63_RS08020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IAU63_RS08020	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IAU63_RS08025	COG1253	flavin adenine dinucleotide binding
IAU63_RS08030	COG0463	Glycosyl transferase, family 2
IAU63_RS08045	COG0602	queuosine metabolic process
IAU63_RS08050	COG0720	synthase
IAU63_RS08060	COG0512	Glutamine amidotransferase of anthranilate synthase
IAU63_RS08080	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IAU63_RS08090	COG1368	sulfuric ester hydrolase activity
IAU63_RS08095	COG0463	Glycosyl transferase, family 2
IAU63_RS08120	COG0488	(ABC) transporter
IAU63_RS08125	COG0514	ATP-dependent DNA helicase (RecQ)
IAU63_RS08130	COG1125	glycine betaine transport
IAU63_RS08130	COG0517	IMP dehydrogenase activity
IAU63_RS08135	COG1174	glycine betaine transport
IAU63_RS08140	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IAU63_RS08155	COG3104	oligopeptide transport
IAU63_RS08160	COG3104	oligopeptide transport
IAU63_RS08190	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IAU63_RS08195	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IAU63_RS08205	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IAU63_RS08220	COG3118	belongs to the thioredoxin family
IAU63_RS08225	COG1929	Belongs to the glycerate kinase type-1 family
IAU63_RS08235	COG2195	Cleaves the N-terminal amino acid of tripeptides
IAU63_RS08255	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IAU63_RS08260	COG1739	Uncharacterized protein family UPF0029
IAU63_RS08270	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
IAU63_RS08285	COG0653	protein targeting
IAU63_RS08320	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IAU63_RS08325	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IAU63_RS08330	COG0110	maltose O-acetyltransferase activity
IAU63_RS08345	COG1660	Displays ATPase and GTPase activities
IAU63_RS08350	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IAU63_RS08355	COG1481	regulation of sporulation
IAU63_RS08370	COG0740	serine-type endopeptidase activity
IAU63_RS08380	COG1090	epimerase
IAU63_RS08400	COG0126	phosphoglycerate kinase activity
IAU63_RS08405	COG0149	triose-phosphate isomerase activity
IAU63_RS08410	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IAU63_RS08415	COG0148	phosphopyruvate hydratase activity
IAU63_RS08425	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IAU63_RS08430	COG1647	Serine aminopeptidase, S33
IAU63_RS08435	COG0557	exoribonuclease II activity
IAU63_RS08470	COG0346	lactoylglutathione lyase activity
IAU63_RS08490	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IAU63_RS08505	COG1764	response to oxidative stress
IAU63_RS08515	COG0710	3-dehydroquinate dehydratase activity
IAU63_RS08525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IAU63_RS08530	COG1393	Belongs to the ArsC family
IAU63_RS08540	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
IAU63_RS08545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IAU63_RS08550	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IAU63_RS08555	COG2011	ABC-type metal ion transport system permease component
IAU63_RS08560	COG1464	Belongs to the NlpA lipoprotein family
IAU63_RS08565	COG1464	Belongs to the NlpA lipoprotein family
IAU63_RS08575	COG0396	ATPase activity
IAU63_RS08580	COG0719	Fe-S assembly protein
IAU63_RS08590	COG0822	iron-sulfur transferase activity
IAU63_RS08595	COG0719	Fe-S assembly protein
IAU63_RS08605	COG4536	flavin adenine dinucleotide binding
IAU63_RS08620	COG1801	Protein of unknown function DUF72
IAU63_RS08625	COG0730	response to heat
IAU63_RS08630	COG0737	Belongs to the 5'-nucleotidase family
IAU63_RS08635	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IAU63_RS08640	COG4470	Protein conserved in bacteria
IAU63_RS08650	COG2445	Protein of unknown function DUF86
IAU63_RS08655	COG0647	UMP catabolic process
IAU63_RS08660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IAU63_RS08665	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IAU63_RS08670	COG4837	Protein of unknown function (DUF1462)
IAU63_RS08675	COG1252	NADH dehydrogenase
IAU63_RS08680	COG4844	belongs to the
IAU63_RS08685	COG0316	Belongs to the HesB IscA family
IAU63_RS08690	COG1252	NADH dehydrogenase
IAU63_RS08695	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IAU63_RS08700	COG2056	Na+-H+ antiporter family
IAU63_RS08710	COG1320	monovalent cation:proton antiporter activity
IAU63_RS08715	COG2212	antiporter activity
IAU63_RS08720	COG1863	multisubunit Na H antiporter MnhE subunit
IAU63_RS08725	COG0651	ATP synthesis coupled electron transport
IAU63_RS08730	COG1006	Multisubunit Na H antiporter MnhC subunit
IAU63_RS08735	COG2111	Na H antiporter
IAU63_RS08740	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IAU63_RS08740	COG2111	Na H antiporter
IAU63_RS08750	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IAU63_RS08780	COG1120	ATPase activity
IAU63_RS08835	COG1278	Cold shock
IAU63_RS08845	COG1098	S1 RNA binding domain
IAU63_RS08850	COG1012	belongs to the aldehyde dehydrogenase family
IAU63_RS08865	COG0584	glycerophosphoryl diester phosphodiesterase
IAU63_RS08875	COG0137	argininosuccinate synthase activity
IAU63_RS08880	COG0166	Belongs to the GPI family
IAU63_RS08895	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
IAU63_RS08905	COG0179	Fumarylacetoacetate (FAA) hydrolase
IAU63_RS08920	COG0446	pyridine nucleotide-disulphide oxidoreductase
IAU63_RS08925	COG0561	phosphatase activity
IAU63_RS08945	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
IAU63_RS08970	COG0601	transmembrane transport
IAU63_RS08975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAU63_RS08980	COG0444	Belongs to the ABC transporter superfamily
IAU63_RS08985	COG4608	Belongs to the ABC transporter superfamily
IAU63_RS08990	COG4166	transmembrane transport
IAU63_RS08995	COG0180	Tryptophanyl-tRNA synthetase
IAU63_RS09000	COG1393	Belongs to the ArsC family
IAU63_RS09025	COG1164	Oligoendopeptidase f
IAU63_RS09035	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IAU63_RS09040	COG2346	COG2346, Truncated hemoglobins
IAU63_RS09055	COG2357	RelA SpoT domain protein
IAU63_RS09065	COG0564	pseudouridine synthase activity
IAU63_RS09070	COG2239	Acts as a magnesium transporter
IAU63_RS09075	COG0475	glutathione-regulated potassium exporter activity
IAU63_RS09075	COG0569	domain protein
IAU63_RS09085	COG0673	inositol 2-dehydrogenase activity
IAU63_RS09090	COG2211	Major facilitator Superfamily
IAU63_RS09095	COG4409	exo-alpha-(2->6)-sialidase activity
IAU63_RS09100	COG0628	permease
IAU63_RS09105	COG1115	amino acid carrier protein
IAU63_RS09110	COG2382	esterase
IAU63_RS09115	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IAU63_RS09140	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IAU63_RS09170	COG3716	PTS system mannose fructose sorbose family IID component
IAU63_RS09175	COG3715	PTS system
IAU63_RS09185	COG2814	Major facilitator Superfamily
IAU63_RS09190	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IAU63_RS09195	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IAU63_RS09205	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IAU63_RS09210	COG0861	Integral membrane protein TerC family
IAU63_RS09215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IAU63_RS09220	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IAU63_RS09225	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
IAU63_RS09235	COG1696	Membrane protein involved in D-alanine export
IAU63_RS09240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IAU63_RS09250	COG0737	Belongs to the 5'-nucleotidase family
IAU63_RS09290	COG4873	Protein conserved in bacteria
IAU63_RS09310	COG4619	ABC transporter
IAU63_RS09315	COG0390	transport system, permease component
IAU63_RS09320	COG1575	Belongs to the MenA family. Type 1 subfamily
IAU63_RS09325	COG1169	isochorismate synthase
IAU63_RS09330	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IAU63_RS09340	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
IAU63_RS09345	COG0436	Aminotransferase
IAU63_RS09350	COG3594	Acyltransferase
IAU63_RS09375	COG1316	TRANSCRIPTIONal
IAU63_RS09380	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IAU63_RS09410	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IAU63_RS09420	COG1215	transferase activity, transferring glycosyl groups
IAU63_RS09430	COG1682	transport, permease protein
IAU63_RS09440	COG1134	teichoic acid transport
IAU63_RS09455	COG3212	peptidase
IAU63_RS09465	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IAU63_RS09470	COG1845	cytochrome c oxidase, subunit III
IAU63_RS09480	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IAU63_RS09495	COG1017	nitric oxide dioxygenase activity
IAU63_RS09495	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IAU63_RS09500	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IAU63_RS09505	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IAU63_RS09510	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IAU63_RS09515	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IAU63_RS09520	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IAU63_RS09525	COG0047	phosphoribosylformylglycinamidine synthase activity
IAU63_RS09535	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IAU63_RS09540	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IAU63_RS09550	COG0138	bifunctional purine biosynthesis protein purh
IAU63_RS09555	COG0151	Belongs to the GarS family
IAU63_RS09565	COG4172	Belongs to the ABC transporter superfamily
IAU63_RS09580	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IAU63_RS09590	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IAU63_RS09595	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IAU63_RS09600	COG1393	Belongs to the ArsC family
IAU63_RS09605	COG1271	oxidase subunit
IAU63_RS09610	COG1294	oxidase, subunit
IAU63_RS09615	COG0569	domain protein
IAU63_RS09640	COG0492	ferredoxin-NADP+ reductase activity
IAU63_RS09645	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IAU63_RS09650	COG5503	Protein of unknown function (DUF1447)
IAU63_RS09695	COG4476	Belongs to the UPF0223 family
IAU63_RS09705	COG3842	ATPase activity
IAU63_RS09715	COG1177	transmembrane transport
IAU63_RS09720	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IAU63_RS09735	COG4493	Belongs to the UPF0637 family
IAU63_RS09740	COG0483	inositol monophosphate 1-phosphatase activity
IAU63_RS09750	COG1217	gtp-binding protein TYPA
IAU63_RS09755	COG1902	pentaerythritol trinitrate reductase activity
IAU63_RS09760	COG4896	Protein conserved in bacteria
IAU63_RS09765	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IAU63_RS09770	COG4838	Belongs to the UPF0358 family
IAU63_RS09775	COG0772	Belongs to the SEDS family
IAU63_RS09780	COG3344	reverse transcriptase
IAU63_RS09800	COG0109	protoheme IX farnesyltransferase activity
IAU63_RS09815	COG3679	Belongs to the UPF0342 family
IAU63_RS09820	COG0584	glycerophosphoryl diester phosphodiesterase
IAU63_RS09825	COG4471	UPF0298 protein
IAU63_RS09835	COG0742	ribosomal rna small subunit methyltransferase
IAU63_RS09855	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IAU63_RS09860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IAU63_RS09865	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IAU63_RS09880	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IAU63_RS09895	COG1796	DNA polymerase
IAU63_RS09895	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IAU63_RS09900	COG1193	negative regulation of DNA recombination
IAU63_RS09905	COG3118	belongs to the thioredoxin family
IAU63_RS09910	COG0322	excinuclease ABC activity
IAU63_RS09915	COG2009	succinate dehydrogenase
IAU63_RS09920	COG1053	succinate dehydrogenase
IAU63_RS09925	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IAU63_RS09930	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IAU63_RS09975	COG0783	Belongs to the Dps family
IAU63_RS09980	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IAU63_RS10015	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IAU63_RS10030	COG1011	Hydrolase
IAU63_RS10035	COG0454	-acetyltransferase
IAU63_RS10040	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
IAU63_RS10045	COG2001	Belongs to the MraZ family
IAU63_RS10050	COG0275	rRNA processing
IAU63_RS10055	COG4839	cell division protein FtsL
IAU63_RS10060	COG0768	penicillin binding
IAU63_RS10070	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IAU63_RS10080	COG0849	cell division
IAU63_RS10085	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IAU63_RS10095	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IAU63_RS10100	COG1799	cell septum assembly
IAU63_RS10105	COG0762	integral membrane protein
IAU63_RS10115	COG1869	D-ribose catabolic process
IAU63_RS10120	COG4975	Glucose uptake
IAU63_RS10130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IAU63_RS10135	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IAU63_RS10150	COG3599	regulation of cell shape
IAU63_RS10155	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IAU63_RS10160	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IAU63_RS10165	COG0564	pseudouridine synthase activity
IAU63_RS10170	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IAU63_RS10190	COG0505	Belongs to the CarA family
IAU63_RS10195	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IAU63_RS10205	COG0167	dihydroorotate dehydrogenase activity
IAU63_RS10210	COG0284	orotidine-5'-phosphate decarboxylase activity
IAU63_RS10215	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IAU63_RS10235	COG1758	RNA polymerase activity
IAU63_RS10255	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IAU63_RS10260	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IAU63_RS10265	COG0242	peptide deformylase activity
IAU63_RS10270	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IAU63_RS10275	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IAU63_RS10275	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IAU63_RS10280	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IAU63_RS10295	COG2124	cytochrome p450
IAU63_RS10305	COG1162	GTPase activity
IAU63_RS10310	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IAU63_RS10325	COG1302	Protein conserved in bacteria
IAU63_RS10335	COG1760	l-serine dehydratase
IAU63_RS10340	COG1760	l-serine dehydratase
IAU63_RS10350	COG1349	DNA-binding transcription factor activity
IAU63_RS10355	COG0416	fatty acid biosynthetic process
IAU63_RS10370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IAU63_RS10375	COG0571	ribonuclease III activity
IAU63_RS10380	COG1196	nuclear chromosome segregation
IAU63_RS10385	COG0552	protein localization to endoplasmic reticulum
IAU63_RS10390	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
IAU63_RS10395	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IAU63_RS10415	COG1401	restriction endodeoxyribonuclease activity
IAU63_RS10425	COG0228	four-way junction DNA binding
IAU63_RS10430	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IAU63_RS10435	COG0336	Belongs to the RNA methyltransferase TrmD family
IAU63_RS10475	COG4485	Bacterial membrane protein, YfhO
IAU63_RS10490	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IAU63_RS10500	COG0045	succinate-CoA ligase (ADP-forming) activity
IAU63_RS10510	COG0758	DNA mediated transformation
IAU63_RS10515	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IAU63_RS10520	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
IAU63_RS10525	COG4974	Belongs to the 'phage' integrase family
IAU63_RS10530	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IAU63_RS10535	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IAU63_RS10540	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
IAU63_RS10545	COG0052	Belongs to the universal ribosomal protein uS2 family
IAU63_RS10550	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IAU63_RS10555	COG0528	UMP kinase activity
IAU63_RS10560	COG0233	cytoplasmic translational termination
IAU63_RS10570	COG4589	Belongs to the CDS family
IAU63_RS10575	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IAU63_RS10585	COG0442	prolyl-tRNA aminoacylation
IAU63_RS10595	COG0779	Required for maturation of 30S ribosomal subunits
IAU63_RS10600	COG0195	Participates in both transcription termination and antitermination
IAU63_RS10605	COG2740	Nucleic-acid-binding protein implicated in transcription termination
IAU63_RS10610	COG1358	cellular component organization or biogenesis
IAU63_RS10615	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IAU63_RS10625	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IAU63_RS10630	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IAU63_RS10635	COG0196	riboflavin kinase activity
IAU63_RS10645	COG1185	polyribonucleotide nucleotidyltransferase activity
IAU63_RS10660	COG2188	Transcriptional regulator
IAU63_RS10665	COG0612	Peptidase, M16
IAU63_RS10670	COG0612	Peptidase, M16
IAU63_RS10675	COG0300	oxidoreductase activity
IAU63_RS10695	COG1546	Belongs to the CinA family
IAU63_RS10695	COG1058	Belongs to the CinA family
IAU63_RS10700	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IAU63_RS10705	COG1418	mRNA catabolic process
IAU63_RS10725	COG1692	metallophosphoesterase
IAU63_RS10730	COG0674	pyruvate-flavodoxin oxidoreductase activity
IAU63_RS10730	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IAU63_RS10735	COG1013	pyruvate-flavodoxin oxidoreductase activity
IAU63_RS10745	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IAU63_RS10765	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IAU63_RS10770	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
IAU63_RS10775	COG1619	proteins homologs of microcin C7 resistance protein MccF
IAU63_RS10780	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IAU63_RS10790	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IAU63_RS10795	COG1923	regulation of RNA biosynthetic process
IAU63_RS10800	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IAU63_RS10805	COG2267	carboxylic ester hydrolase activity
IAU63_RS10810	COG0386	Belongs to the glutathione peroxidase family
IAU63_RS10815	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IAU63_RS10820	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
IAU63_RS10825	COG0789	Transcriptional regulator
IAU63_RS10845	COG0584	glycerophosphoryl diester phosphodiesterase
IAU63_RS10875	COG1525	nuclease
IAU63_RS10900	COG0527	aspartate kinase activity
IAU63_RS10905	COG0460	homoserine dehydrogenase
IAU63_RS10910	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IAU63_RS10915	COG0083	homoserine kinase activity
IAU63_RS10930	COG0833	amino acid
IAU63_RS10940	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IAU63_RS10945	COG0516	GMP reductase activity
IAU63_RS10955	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IAU63_RS10965	COG4224	UPF0291 protein
IAU63_RS10975	COG3763	UPF0154 protein
IAU63_RS10980	COG4846	Membrane protein involved in cytochrome C biogenesis
IAU63_RS10985	COG0420	3'-5' exonuclease activity
IAU63_RS10990	COG0419	ATPase involved in DNA repair
IAU63_RS10995	COG1970	mechanosensitive ion channel activity
IAU63_RS11000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IAU63_RS11010	COG0824	Thioesterase
IAU63_RS11015	COG4841	protein insertion into membrane
IAU63_RS11020	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IAU63_RS11030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IAU63_RS11035	COG1115	amino acid carrier protein
IAU63_RS11040	COG3711	transcriptional antiterminator
IAU63_RS11050	COG0628	permease
IAU63_RS11070	COG1942	4-Oxalocrotonate Tautomerase
IAU63_RS11080	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IAU63_RS11085	COG0287	Prephenate dehydrogenase
IAU63_RS11090	COG1363	Peptidase, m42
IAU63_RS11120	COG2996	Protein conserved in bacteria
IAU63_RS11125	COG0488	(ABC) transporter
IAU63_RS11130	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IAU63_RS11135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IAU63_RS11140	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IAU63_RS11145	COG2171	N-acyltransferase activity
IAU63_RS11150	COG1473	amidohydrolase
IAU63_RS11170	COG1278	Cold shock
IAU63_RS11190	COG3853	Toxic anion resistance protein (TelA)
IAU63_RS11200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IAU63_RS11205	COG1114	Component of the transport system for branched-chain amino acids
IAU63_RS11210	COG4548	von Willebrand factor, type A
IAU63_RS11215	COG0714	Associated with various cellular activities
IAU63_RS11240	COG0567	Dehydrogenase, E1 component
IAU63_RS11245	COG5002	protein histidine kinase activity
IAU63_RS11255	COG0671	phosphoesterase, PA-phosphatase related
IAU63_RS11260	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IAU63_RS11270	COG0793	Belongs to the peptidase S41A family
IAU63_RS11280	COG2190	(PTS) system
IAU63_RS11315	COG1413	lyase activity
IAU63_RS11325	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IAU63_RS11335	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IAU63_RS11340	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
IAU63_RS11345	COG2962	Rard protein
IAU63_RS11350	COG0116	Belongs to the methyltransferase superfamily
IAU63_RS11360	COG3599	regulation of cell shape
IAU63_RS11365	COG4474	Belongs to the UPF0398 family
IAU63_RS11380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IAU63_RS11380	COG4499	WXG100 protein secretion system (Wss), protein YukC
IAU63_RS11390	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IAU63_RS11395	COG3935	DnaD domain protein
IAU63_RS11400	COG0017	Asparaginyl-tRNA synthetase
IAU63_RS11415	COG0617	tRNA 3'-terminal CCA addition
IAU63_RS11420	COG0438	transferase activity, transferring glycosyl groups
IAU63_RS11425	COG1694	Mazg nucleotide pyrophosphohydrolase
IAU63_RS11435	COG4347	Protein of unknown function (DUF1405)
IAU63_RS11440	COG5582	Belongs to the UPF0302 family
IAU63_RS11445	COG0457	Tetratricopeptide repeat
IAU63_RS11455	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IAU63_RS11465	COG0105	UTP biosynthetic process
IAU63_RS11470	COG0142	geranyltranstransferase activity
IAU63_RS11490	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IAU63_RS11495	COG1160	GTP binding
IAU63_RS11500	COG0539	negative regulation of cytoplasmic translation
IAU63_RS11510	COG0252	asparaginase activity
IAU63_RS11515	COG0492	ferredoxin-NADP+ reductase activity
IAU63_RS11525	COG0514	ATP-dependent DNA helicase (RecQ)
IAU63_RS11535	COG1141	Ferredoxin
IAU63_RS11550	COG0745	RESPONSE REGULATOR receiver
IAU63_RS11555	COG1187	pseudouridine synthase activity
IAU63_RS11560	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IAU63_RS11565	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IAU63_RS11580	COG0735	belongs to the Fur family
IAU63_RS11585	COG0494	nUDIX hydrolase
IAU63_RS11590	COG0667	Aldo Keto reductase
IAU63_RS11600	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IAU63_RS11605	COG1234	tRNA 3'-trailer cleavage
IAU63_RS11610	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IAU63_RS11640	COG2195	Cleaves the N-terminal amino acid of tripeptides
IAU63_RS11650	COG4129	membrane
IAU63_RS11660	COG0508	dehydrogenase complex catalyzes the overall conversion of
IAU63_RS11665	COG0022	dehydrogenase e1 component
IAU63_RS11670	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IAU63_RS11675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IAU63_RS11680	COG3426	butyrate kinase activity
IAU63_RS11685	COG0280	phosphate acetyltransferase
IAU63_RS11690	COG0497	DNA recombination
IAU63_RS11695	COG1438	arginine binding
IAU63_RS11700	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IAU63_RS11710	COG1722	exodeoxyribonuclease VII activity
IAU63_RS11715	COG1570	exodeoxyribonuclease VII activity
IAU63_RS11725	COG1302	Protein conserved in bacteria
IAU63_RS11730	COG0439	Biotin carboxylase
IAU63_RS11735	COG0511	ligase activity, forming carbon-carbon bonds
IAU63_RS11740	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IAU63_RS11745	COG0006	proline dipeptidase activity
IAU63_RS11760	COG0095	Lipoate-protein ligase
IAU63_RS11765	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IAU63_RS11770	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IAU63_RS11780	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IAU63_RS11785	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IAU63_RS11815	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IAU63_RS11820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IAU63_RS11825	COG0011	TIGRFAM Protein of
IAU63_RS11830	COG1940	carbohydrate kinase activity
IAU63_RS11835	COG4483	Protein conserved in bacteria
IAU63_RS11840	COG0705	Rhomboid family
IAU63_RS11840	COG0457	Tetratricopeptide repeat
IAU63_RS11845	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IAU63_RS11855	COG0704	Plays a role in the regulation of phosphate uptake
IAU63_RS11860	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IAU63_RS11865	COG0581	inorganic phosphate transmembrane transporter activity
IAU63_RS11870	COG0573	inorganic phosphate transmembrane transporter activity
IAU63_RS11875	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IAU63_RS11880	COG0768	penicillin binding
IAU63_RS11890	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IAU63_RS11895	COG0735	belongs to the Fur family
IAU63_RS11900	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IAU63_RS11905	COG1121	(ABC) transporter
IAU63_RS11910	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IAU63_RS11915	COG0513	Belongs to the DEAD box helicase family
IAU63_RS11920	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IAU63_RS11925	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IAU63_RS11930	COG2384	SAM-dependent methyltransferase
IAU63_RS11935	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IAU63_RS11940	COG0358	DNA primase activity
IAU63_RS11945	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IAU63_RS11950	COG0517	IMP dehydrogenase activity
IAU63_RS11955	COG0423	glycine-tRNA ligase activity
IAU63_RS11960	COG1381	Involved in DNA repair and RecF pathway recombination
IAU63_RS11965	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IAU63_RS11975	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IAU63_RS11985	COG1702	phosphate starvation-inducible protein PhoH
IAU63_RS11995	COG4864	UPF0365 protein
IAU63_RS12000	COG1030	water channel activity
IAU63_RS12015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IAU63_RS12020	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IAU63_RS12025	COG2264	protein methyltransferase activity
IAU63_RS12030	COG0484	heat shock protein binding
IAU63_RS12035	COG0443	Heat shock 70 kDa protein
IAU63_RS12050	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IAU63_RS12060	COG0268	Binds directly to 16S ribosomal RNA
IAU63_RS12065	COG1466	dna polymerase III delta subunit
IAU63_RS12070	COG2333	competence protein COMEC
IAU63_RS12070	COG0658	competence protein
IAU63_RS12075	COG2131	deaminase
IAU63_RS12080	COG1596	polysaccharide export
IAU63_RS12080	COG1555	photosystem II stabilization
IAU63_RS12085	COG2226	methyltransferase
IAU63_RS12090	COG0799	negative regulation of ribosome biogenesis
IAU63_RS12095	COG1713	HD superfamily hydrolase involved in NAD metabolism
IAU63_RS12105	COG1534	Rna-binding protein
IAU63_RS12110	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IAU63_RS12115	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IAU63_RS12120	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
IAU63_RS12125	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IAU63_RS12130	COG1914	H( )-stimulated, divalent metal cation uptake system
IAU63_RS12135	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IAU63_RS12140	COG0439	Biotin carboxylase
IAU63_RS12145	COG0511	ligase activity, forming carbon-carbon bonds
IAU63_RS12150	COG1984	allophanate hydrolase subunit 2
IAU63_RS12155	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IAU63_RS12165	COG0572	uridine kinase
IAU63_RS12170	COG0826	peptidase U32
IAU63_RS12175	COG0826	peptidase U32
IAU63_RS12180	COG4122	O-methyltransferase activity
IAU63_RS12185	COG3906	Belongs to the UPF0473 family
IAU63_RS12190	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IAU63_RS12195	COG4472	Bacterial protein of unknown function (DUF965)
IAU63_RS12200	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IAU63_RS12205	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IAU63_RS12215	COG0482	sulfurtransferase activity
IAU63_RS12220	COG1104	cysteine desulfurase activity
IAU63_RS12225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAU63_RS12240	COG1959	2 iron, 2 sulfur cluster binding
IAU63_RS12245	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IAU63_RS12250	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IAU63_RS12260	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IAU63_RS12270	COG0860	N-Acetylmuramoyl-L-alanine amidase
IAU63_RS12275	COG1490	D-aminoacyl-tRNA deacylase activity
IAU63_RS12285	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IAU63_RS12290	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IAU63_RS12290	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IAU63_RS12295	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IAU63_RS12295	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IAU63_RS12300	COG1862	Preprotein translocase
IAU63_RS12310	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IAU63_RS12320	COG0632	four-way junction helicase activity
IAU63_RS12330	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IAU63_RS12340	COG2868	ribosomal protein
IAU63_RS12375	COG2003	Belongs to the UPF0758 family
IAU63_RS12385	COG0285	dihydrofolate synthase activity
IAU63_RS12390	COG0525	valine-tRNA ligase activity
IAU63_RS12395	COG2818	Glycosylase
IAU63_RS12405	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IAU63_RS12420	COG0181	hydroxymethylbilane synthase activity
IAU63_RS12430	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IAU63_RS12435	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IAU63_RS12445	COG0544	peptidyl-prolyl cis-trans isomerase activity
IAU63_RS12460	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IAU63_RS12465	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IAU63_RS12470	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IAU63_RS12480	COG0833	amino acid
IAU63_RS12490	COG1484	DNA-dependent DNA replication
IAU63_RS12495	COG3611	Membrane attachment protein
IAU63_RS12510	COG0237	dephospho-CoA kinase activity
IAU63_RS12520	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IAU63_RS12520	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IAU63_RS12525	COG5002	protein histidine kinase activity
IAU63_RS12530	COG0745	RESPONSE REGULATOR receiver
IAU63_RS12535	COG0538	isocitrate dehydrogenase activity
IAU63_RS12540	COG0372	Belongs to the citrate synthase family
IAU63_RS12545	COG0469	pyruvate kinase activity
IAU63_RS12550	COG0205	6-phosphofructokinase activity
IAU63_RS12555	COG0825	malonyl-CoA metabolic process
IAU63_RS12560	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IAU63_RS12565	COG0281	malic enzyme
IAU63_RS12570	COG0587	DNA-directed DNA polymerase activity
IAU63_RS12575	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IAU63_RS12580	COG4109	DRTGG domain
IAU63_RS12590	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IAU63_RS12595	COG0006	proline dipeptidase activity
IAU63_RS12605	COG0686	Belongs to the AlaDH PNT family
IAU63_RS12610	COG0589	response to stress
IAU63_RS12615	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IAU63_RS12620	COG0827	DNA restriction-modification system
IAU63_RS12625	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IAU63_RS12630	COG1714	RDD family
IAU63_RS12635	COG0616	signal peptide processing
IAU63_RS12645	COG0301	tRNA thio-modification
IAU63_RS12650	COG1104	cysteine desulfurase activity
IAU63_RS12655	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
IAU63_RS12660	COG1956	GAF domain-containing protein
IAU63_RS12665	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IAU63_RS12695	COG0456	acetyltransferase
IAU63_RS12730	COG1764	response to oxidative stress
IAU63_RS12735	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IAU63_RS12740	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IAU63_RS12750	COG0204	Acyl-transferase