locus-tag	class	description
H9Q12_RS00005	COG1174	glycine betaine transport
H9Q12_RS00010	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H9Q12_RS00025	COG3104	oligopeptide transport
H9Q12_RS00030	COG3104	oligopeptide transport
H9Q12_RS00060	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H9Q12_RS00065	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H9Q12_RS00075	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H9Q12_RS00090	COG3118	belongs to the thioredoxin family
H9Q12_RS00095	COG1929	Belongs to the glycerate kinase type-1 family
H9Q12_RS00105	COG2195	Cleaves the N-terminal amino acid of tripeptides
H9Q12_RS00125	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H9Q12_RS00130	COG1739	Uncharacterized protein family UPF0029
H9Q12_RS00140	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
H9Q12_RS00155	COG0653	protein targeting
H9Q12_RS00190	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H9Q12_RS00195	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H9Q12_RS00200	COG0110	maltose O-acetyltransferase activity
H9Q12_RS00215	COG1660	Displays ATPase and GTPase activities
H9Q12_RS00220	COG0391	Required for morphogenesis under gluconeogenic growth conditions
H9Q12_RS00225	COG1481	regulation of sporulation
H9Q12_RS00235	COG0740	serine-type endopeptidase activity
H9Q12_RS00245	COG1090	epimerase
H9Q12_RS00265	COG0126	phosphoglycerate kinase activity
H9Q12_RS00270	COG0149	triose-phosphate isomerase activity
H9Q12_RS00275	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H9Q12_RS00280	COG0148	phosphopyruvate hydratase activity
H9Q12_RS00290	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H9Q12_RS00295	COG1647	Serine aminopeptidase, S33
H9Q12_RS00300	COG0557	exoribonuclease II activity
H9Q12_RS00335	COG0346	lactoylglutathione lyase activity
H9Q12_RS00355	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H9Q12_RS00370	COG1764	response to oxidative stress
H9Q12_RS00380	COG0710	3-dehydroquinate dehydratase activity
H9Q12_RS00390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9Q12_RS00395	COG1393	Belongs to the ArsC family
H9Q12_RS00405	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
H9Q12_RS00410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9Q12_RS00415	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H9Q12_RS00420	COG2011	ABC-type metal ion transport system permease component
H9Q12_RS00425	COG1464	Belongs to the NlpA lipoprotein family
H9Q12_RS00430	COG1464	Belongs to the NlpA lipoprotein family
H9Q12_RS00440	COG0396	ATPase activity
H9Q12_RS00445	COG0719	Fe-S assembly protein
H9Q12_RS00455	COG0822	iron-sulfur transferase activity
H9Q12_RS00460	COG0719	Fe-S assembly protein
H9Q12_RS00470	COG4536	flavin adenine dinucleotide binding
H9Q12_RS00485	COG1801	Protein of unknown function DUF72
H9Q12_RS00490	COG0730	response to heat
H9Q12_RS00495	COG0737	Belongs to the 5'-nucleotidase family
H9Q12_RS00500	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H9Q12_RS00505	COG4470	Protein conserved in bacteria
H9Q12_RS00515	COG2445	Protein of unknown function DUF86
H9Q12_RS00520	COG0647	UMP catabolic process
H9Q12_RS00525	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H9Q12_RS00530	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H9Q12_RS00535	COG4837	Protein of unknown function (DUF1462)
H9Q12_RS00540	COG1252	NADH dehydrogenase
H9Q12_RS00545	COG4844	belongs to the
H9Q12_RS00550	COG0316	Belongs to the HesB IscA family
H9Q12_RS00555	COG1252	NADH dehydrogenase
H9Q12_RS00560	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H9Q12_RS00565	COG2056	Na+-H+ antiporter family
H9Q12_RS00575	COG1320	monovalent cation:proton antiporter activity
H9Q12_RS00580	COG2212	antiporter activity
H9Q12_RS00585	COG1863	multisubunit Na H antiporter MnhE subunit
H9Q12_RS00590	COG0651	ATP synthesis coupled electron transport
H9Q12_RS00595	COG1006	Multisubunit Na H antiporter MnhC subunit
H9Q12_RS00600	COG2111	Na H antiporter
H9Q12_RS00605	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H9Q12_RS00605	COG2111	Na H antiporter
H9Q12_RS00615	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H9Q12_RS00645	COG1120	ATPase activity
H9Q12_RS00695	COG1278	Cold shock
H9Q12_RS00705	COG1098	S1 RNA binding domain
H9Q12_RS00710	COG1012	belongs to the aldehyde dehydrogenase family
H9Q12_RS00725	COG0584	glycerophosphoryl diester phosphodiesterase
H9Q12_RS00735	COG0137	argininosuccinate synthase activity
H9Q12_RS00740	COG0166	Belongs to the GPI family
H9Q12_RS00755	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
H9Q12_RS00765	COG0179	Fumarylacetoacetate (FAA) hydrolase
H9Q12_RS00775	COG3344	reverse transcriptase
H9Q12_RS00780	COG0446	pyridine nucleotide-disulphide oxidoreductase
H9Q12_RS00785	COG0561	phosphatase activity
H9Q12_RS00805	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
H9Q12_RS00830	COG0601	transmembrane transport
H9Q12_RS00835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9Q12_RS00840	COG0444	Belongs to the ABC transporter superfamily
H9Q12_RS00845	COG4608	Belongs to the ABC transporter superfamily
H9Q12_RS00850	COG4166	transmembrane transport
H9Q12_RS00855	COG0180	Tryptophanyl-tRNA synthetase
H9Q12_RS00860	COG1393	Belongs to the ArsC family
H9Q12_RS00885	COG1164	Oligoendopeptidase f
H9Q12_RS00895	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H9Q12_RS00900	COG2346	COG2346, Truncated hemoglobins
H9Q12_RS00915	COG2357	RelA SpoT domain protein
H9Q12_RS00925	COG0564	pseudouridine synthase activity
H9Q12_RS00930	COG2239	Acts as a magnesium transporter
H9Q12_RS00935	COG0569	domain protein
H9Q12_RS00935	COG0475	glutathione-regulated potassium exporter activity
H9Q12_RS00945	COG0673	inositol 2-dehydrogenase activity
H9Q12_RS00950	COG2211	Major facilitator Superfamily
H9Q12_RS00955	COG4409	exo-alpha-(2->6)-sialidase activity
H9Q12_RS00960	COG0628	permease
H9Q12_RS00965	COG1115	amino acid carrier protein
H9Q12_RS00970	COG2382	esterase
H9Q12_RS00975	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
H9Q12_RS01000	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H9Q12_RS01030	COG3716	PTS system mannose fructose sorbose family IID component
H9Q12_RS01035	COG3715	PTS system
H9Q12_RS01045	COG2814	Major facilitator Superfamily
H9Q12_RS01050	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H9Q12_RS01055	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H9Q12_RS01065	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H9Q12_RS01070	COG0861	Integral membrane protein TerC family
H9Q12_RS01075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H9Q12_RS01080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H9Q12_RS01085	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
H9Q12_RS01095	COG1696	Membrane protein involved in D-alanine export
H9Q12_RS01100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H9Q12_RS01110	COG0737	Belongs to the 5'-nucleotidase family
H9Q12_RS01150	COG4873	Protein conserved in bacteria
H9Q12_RS01170	COG4619	ABC transporter
H9Q12_RS01175	COG0390	transport system, permease component
H9Q12_RS01180	COG1575	Belongs to the MenA family. Type 1 subfamily
H9Q12_RS01185	COG1169	isochorismate synthase
H9Q12_RS01190	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H9Q12_RS01200	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H9Q12_RS01205	COG0436	Aminotransferase
H9Q12_RS01210	COG3594	Acyltransferase
H9Q12_RS01235	COG1316	TRANSCRIPTIONal
H9Q12_RS01240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H9Q12_RS01270	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H9Q12_RS01280	COG1215	transferase activity, transferring glycosyl groups
H9Q12_RS01290	COG1682	transport, permease protein
H9Q12_RS01300	COG1134	teichoic acid transport
H9Q12_RS01315	COG3212	peptidase
H9Q12_RS01325	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H9Q12_RS01330	COG1845	cytochrome c oxidase, subunit III
H9Q12_RS01340	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H9Q12_RS01350	COG1017	nitric oxide dioxygenase activity
H9Q12_RS01350	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H9Q12_RS01355	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H9Q12_RS01360	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H9Q12_RS01365	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H9Q12_RS01370	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H9Q12_RS01375	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H9Q12_RS01380	COG0047	phosphoribosylformylglycinamidine synthase activity
H9Q12_RS01390	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H9Q12_RS01395	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H9Q12_RS01405	COG0138	bifunctional purine biosynthesis protein purh
H9Q12_RS01410	COG0151	Belongs to the GarS family
H9Q12_RS01420	COG4172	Belongs to the ABC transporter superfamily
H9Q12_RS01435	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H9Q12_RS01445	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9Q12_RS01450	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H9Q12_RS01455	COG1393	Belongs to the ArsC family
H9Q12_RS01460	COG1271	oxidase subunit
H9Q12_RS01465	COG1294	oxidase, subunit
H9Q12_RS01470	COG0569	domain protein
H9Q12_RS01495	COG0492	ferredoxin-NADP+ reductase activity
H9Q12_RS01500	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H9Q12_RS01505	COG5503	Protein of unknown function (DUF1447)
H9Q12_RS01550	COG4476	Belongs to the UPF0223 family
H9Q12_RS01560	COG3842	ATPase activity
H9Q12_RS01570	COG1177	transmembrane transport
H9Q12_RS01575	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H9Q12_RS01590	COG4493	Belongs to the UPF0637 family
H9Q12_RS01595	COG0483	inositol monophosphate 1-phosphatase activity
H9Q12_RS01605	COG1217	gtp-binding protein TYPA
H9Q12_RS01610	COG1902	pentaerythritol trinitrate reductase activity
H9Q12_RS01615	COG4896	Protein conserved in bacteria
H9Q12_RS01620	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H9Q12_RS01625	COG4838	Belongs to the UPF0358 family
H9Q12_RS01630	COG0772	Belongs to the SEDS family
H9Q12_RS01635	COG3344	reverse transcriptase
H9Q12_RS01655	COG0109	protoheme IX farnesyltransferase activity
H9Q12_RS01670	COG3679	Belongs to the UPF0342 family
H9Q12_RS01675	COG0584	glycerophosphoryl diester phosphodiesterase
H9Q12_RS01680	COG4471	UPF0298 protein
H9Q12_RS01690	COG0742	ribosomal rna small subunit methyltransferase
H9Q12_RS01710	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H9Q12_RS01715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9Q12_RS01720	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H9Q12_RS01735	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H9Q12_RS01750	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
H9Q12_RS01750	COG1796	DNA polymerase
H9Q12_RS01755	COG1193	negative regulation of DNA recombination
H9Q12_RS01760	COG3118	belongs to the thioredoxin family
H9Q12_RS01765	COG0322	excinuclease ABC activity
H9Q12_RS01770	COG2009	succinate dehydrogenase
H9Q12_RS01775	COG1053	succinate dehydrogenase
H9Q12_RS01780	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H9Q12_RS01785	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H9Q12_RS01830	COG0783	Belongs to the Dps family
H9Q12_RS01835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9Q12_RS01865	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H9Q12_RS01880	COG1011	Hydrolase
H9Q12_RS01885	COG0454	-acetyltransferase
H9Q12_RS01890	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
H9Q12_RS01895	COG2001	Belongs to the MraZ family
H9Q12_RS01900	COG0275	rRNA processing
H9Q12_RS01905	COG4839	cell division protein FtsL
H9Q12_RS01910	COG0768	penicillin binding
H9Q12_RS01920	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H9Q12_RS01930	COG0849	cell division
H9Q12_RS01935	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H9Q12_RS01945	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H9Q12_RS01950	COG1799	cell septum assembly
H9Q12_RS01955	COG0762	integral membrane protein
H9Q12_RS01965	COG1869	D-ribose catabolic process
H9Q12_RS01970	COG4975	Glucose uptake
H9Q12_RS01980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H9Q12_RS01985	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H9Q12_RS02000	COG3599	regulation of cell shape
H9Q12_RS02005	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H9Q12_RS02010	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H9Q12_RS02015	COG0564	pseudouridine synthase activity
H9Q12_RS02020	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
H9Q12_RS02040	COG0505	Belongs to the CarA family
H9Q12_RS02045	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H9Q12_RS02055	COG0167	dihydroorotate dehydrogenase activity
H9Q12_RS02060	COG0284	orotidine-5'-phosphate decarboxylase activity
H9Q12_RS02065	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H9Q12_RS02085	COG1758	RNA polymerase activity
H9Q12_RS02105	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H9Q12_RS02110	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H9Q12_RS02115	COG0242	peptide deformylase activity
H9Q12_RS02120	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H9Q12_RS02125	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H9Q12_RS02125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H9Q12_RS02130	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H9Q12_RS02145	COG2124	cytochrome p450
H9Q12_RS02155	COG1162	GTPase activity
H9Q12_RS02160	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H9Q12_RS02175	COG1302	Protein conserved in bacteria
H9Q12_RS02185	COG1760	l-serine dehydratase
H9Q12_RS02190	COG1760	l-serine dehydratase
H9Q12_RS02200	COG1349	DNA-binding transcription factor activity
H9Q12_RS02205	COG0416	fatty acid biosynthetic process
H9Q12_RS02220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H9Q12_RS02225	COG0571	ribonuclease III activity
H9Q12_RS02230	COG1196	nuclear chromosome segregation
H9Q12_RS02235	COG0552	protein localization to endoplasmic reticulum
H9Q12_RS02240	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
H9Q12_RS02245	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H9Q12_RS02265	COG1401	restriction endodeoxyribonuclease activity
H9Q12_RS02275	COG0228	four-way junction DNA binding
H9Q12_RS02280	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H9Q12_RS02285	COG0336	Belongs to the RNA methyltransferase TrmD family
H9Q12_RS02325	COG4485	Bacterial membrane protein, YfhO
H9Q12_RS02340	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H9Q12_RS02350	COG0045	succinate-CoA ligase (ADP-forming) activity
H9Q12_RS02360	COG0758	DNA mediated transformation
H9Q12_RS02365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H9Q12_RS02370	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
H9Q12_RS02375	COG4974	Belongs to the 'phage' integrase family
H9Q12_RS02380	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H9Q12_RS02385	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H9Q12_RS02390	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
H9Q12_RS02395	COG0052	Belongs to the universal ribosomal protein uS2 family
H9Q12_RS02400	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H9Q12_RS02405	COG0528	UMP kinase activity
H9Q12_RS02410	COG0233	cytoplasmic translational termination
H9Q12_RS02420	COG4589	Belongs to the CDS family
H9Q12_RS02425	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H9Q12_RS02435	COG0442	prolyl-tRNA aminoacylation
H9Q12_RS02445	COG0779	Required for maturation of 30S ribosomal subunits
H9Q12_RS02450	COG0195	Participates in both transcription termination and antitermination
H9Q12_RS02455	COG2740	Nucleic-acid-binding protein implicated in transcription termination
H9Q12_RS02460	COG1358	cellular component organization or biogenesis
H9Q12_RS02465	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H9Q12_RS02475	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H9Q12_RS02480	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H9Q12_RS02485	COG0196	riboflavin kinase activity
H9Q12_RS02495	COG1185	polyribonucleotide nucleotidyltransferase activity
H9Q12_RS02510	COG2188	Transcriptional regulator
H9Q12_RS02515	COG0612	Peptidase, M16
H9Q12_RS02520	COG0612	Peptidase, M16
H9Q12_RS02525	COG0300	oxidoreductase activity
H9Q12_RS02545	COG1058	Belongs to the CinA family
H9Q12_RS02545	COG1546	Belongs to the CinA family
H9Q12_RS02550	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H9Q12_RS02555	COG1418	mRNA catabolic process
H9Q12_RS02575	COG1692	metallophosphoesterase
H9Q12_RS02580	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H9Q12_RS02580	COG0674	pyruvate-flavodoxin oxidoreductase activity
H9Q12_RS02585	COG1013	pyruvate-flavodoxin oxidoreductase activity
H9Q12_RS02595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H9Q12_RS02615	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H9Q12_RS02620	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
H9Q12_RS02625	COG1619	proteins homologs of microcin C7 resistance protein MccF
H9Q12_RS02630	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H9Q12_RS02640	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H9Q12_RS02645	COG1923	regulation of RNA biosynthetic process
H9Q12_RS02650	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H9Q12_RS02655	COG2267	carboxylic ester hydrolase activity
H9Q12_RS02660	COG0386	Belongs to the glutathione peroxidase family
H9Q12_RS02665	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H9Q12_RS02670	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
H9Q12_RS02675	COG0789	Transcriptional regulator
H9Q12_RS02695	COG0584	glycerophosphoryl diester phosphodiesterase
H9Q12_RS02725	COG1525	nuclease
H9Q12_RS02750	COG0527	aspartate kinase activity
H9Q12_RS02755	COG0460	homoserine dehydrogenase
H9Q12_RS02760	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H9Q12_RS02765	COG0083	homoserine kinase activity
H9Q12_RS02780	COG0833	amino acid
H9Q12_RS02790	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H9Q12_RS02795	COG0516	GMP reductase activity
H9Q12_RS02805	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H9Q12_RS02815	COG4224	UPF0291 protein
H9Q12_RS02825	COG3763	UPF0154 protein
H9Q12_RS02830	COG4846	Membrane protein involved in cytochrome C biogenesis
H9Q12_RS02835	COG0420	3'-5' exonuclease activity
H9Q12_RS02840	COG0419	ATPase involved in DNA repair
H9Q12_RS02845	COG1970	mechanosensitive ion channel activity
H9Q12_RS02850	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H9Q12_RS02860	COG0824	Thioesterase
H9Q12_RS02865	COG4841	protein insertion into membrane
H9Q12_RS02870	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H9Q12_RS02880	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H9Q12_RS02885	COG1115	amino acid carrier protein
H9Q12_RS02890	COG3711	transcriptional antiterminator
H9Q12_RS02900	COG0628	permease
H9Q12_RS02920	COG1942	4-Oxalocrotonate Tautomerase
H9Q12_RS02930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H9Q12_RS02935	COG0287	Prephenate dehydrogenase
H9Q12_RS02940	COG1363	Peptidase, m42
H9Q12_RS02970	COG2996	Protein conserved in bacteria
H9Q12_RS02975	COG0488	(ABC) transporter
H9Q12_RS02980	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H9Q12_RS02985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H9Q12_RS02990	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H9Q12_RS02995	COG2171	N-acyltransferase activity
H9Q12_RS03000	COG1473	amidohydrolase
H9Q12_RS03020	COG1278	Cold shock
H9Q12_RS03040	COG3853	Toxic anion resistance protein (TelA)
H9Q12_RS03050	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H9Q12_RS03055	COG1114	Component of the transport system for branched-chain amino acids
H9Q12_RS03060	COG4548	von Willebrand factor, type A
H9Q12_RS03065	COG0714	Associated with various cellular activities
H9Q12_RS03090	COG0567	Dehydrogenase, E1 component
H9Q12_RS03095	COG5002	protein histidine kinase activity
H9Q12_RS03105	COG0671	phosphoesterase, PA-phosphatase related
H9Q12_RS03110	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H9Q12_RS03120	COG0793	Belongs to the peptidase S41A family
H9Q12_RS03130	COG2190	(PTS) system
H9Q12_RS03165	COG1413	lyase activity
H9Q12_RS03175	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H9Q12_RS03185	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9Q12_RS03190	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
H9Q12_RS03195	COG2962	Rard protein
H9Q12_RS03200	COG0116	Belongs to the methyltransferase superfamily
H9Q12_RS03210	COG3599	regulation of cell shape
H9Q12_RS03215	COG4474	Belongs to the UPF0398 family
H9Q12_RS03230	COG4499	WXG100 protein secretion system (Wss), protein YukC
H9Q12_RS03230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H9Q12_RS03240	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H9Q12_RS03245	COG3935	DnaD domain protein
H9Q12_RS03250	COG0017	Asparaginyl-tRNA synthetase
H9Q12_RS03265	COG0617	tRNA 3'-terminal CCA addition
H9Q12_RS03270	COG0438	transferase activity, transferring glycosyl groups
H9Q12_RS03275	COG1694	Mazg nucleotide pyrophosphohydrolase
H9Q12_RS03285	COG4347	Protein of unknown function (DUF1405)
H9Q12_RS03290	COG5582	Belongs to the UPF0302 family
H9Q12_RS03295	COG0457	Tetratricopeptide repeat
H9Q12_RS03305	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H9Q12_RS03315	COG0105	UTP biosynthetic process
H9Q12_RS03320	COG0142	geranyltranstransferase activity
H9Q12_RS03340	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H9Q12_RS03345	COG1160	GTP binding
H9Q12_RS03350	COG0539	negative regulation of cytoplasmic translation
H9Q12_RS03360	COG0252	asparaginase activity
H9Q12_RS03365	COG0492	ferredoxin-NADP+ reductase activity
H9Q12_RS03375	COG0514	ATP-dependent DNA helicase (RecQ)
H9Q12_RS03385	COG1141	Ferredoxin
H9Q12_RS03400	COG0745	RESPONSE REGULATOR receiver
H9Q12_RS03405	COG1187	pseudouridine synthase activity
H9Q12_RS03410	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H9Q12_RS03415	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H9Q12_RS03430	COG0735	belongs to the Fur family
H9Q12_RS03435	COG0494	nUDIX hydrolase
H9Q12_RS03440	COG0667	Aldo Keto reductase
H9Q12_RS03450	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H9Q12_RS03455	COG1234	tRNA 3'-trailer cleavage
H9Q12_RS03460	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H9Q12_RS03490	COG2195	Cleaves the N-terminal amino acid of tripeptides
H9Q12_RS03500	COG4129	membrane
H9Q12_RS03510	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9Q12_RS03515	COG0022	dehydrogenase e1 component
H9Q12_RS03520	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H9Q12_RS03525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9Q12_RS03530	COG3426	butyrate kinase activity
H9Q12_RS03535	COG0280	phosphate acetyltransferase
H9Q12_RS03540	COG0497	DNA recombination
H9Q12_RS03545	COG1438	arginine binding
H9Q12_RS03550	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H9Q12_RS03560	COG1722	exodeoxyribonuclease VII activity
H9Q12_RS03565	COG1570	exodeoxyribonuclease VII activity
H9Q12_RS03575	COG1302	Protein conserved in bacteria
H9Q12_RS03580	COG0439	Biotin carboxylase
H9Q12_RS03585	COG0511	ligase activity, forming carbon-carbon bonds
H9Q12_RS03590	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H9Q12_RS03595	COG0006	proline dipeptidase activity
H9Q12_RS03610	COG0095	Lipoate-protein ligase
H9Q12_RS03615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H9Q12_RS03620	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H9Q12_RS03630	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H9Q12_RS03635	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H9Q12_RS03665	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H9Q12_RS03670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9Q12_RS03675	COG0011	TIGRFAM Protein of
H9Q12_RS03680	COG1940	carbohydrate kinase activity
H9Q12_RS03685	COG4483	Protein conserved in bacteria
H9Q12_RS03690	COG0705	Rhomboid family
H9Q12_RS03690	COG0457	Tetratricopeptide repeat
H9Q12_RS03695	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H9Q12_RS03705	COG0704	Plays a role in the regulation of phosphate uptake
H9Q12_RS03710	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H9Q12_RS03715	COG0581	inorganic phosphate transmembrane transporter activity
H9Q12_RS03720	COG0573	inorganic phosphate transmembrane transporter activity
H9Q12_RS03725	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H9Q12_RS03730	COG0768	penicillin binding
H9Q12_RS03740	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H9Q12_RS03745	COG0735	belongs to the Fur family
H9Q12_RS03750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H9Q12_RS03755	COG1121	(ABC) transporter
H9Q12_RS03760	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
H9Q12_RS03765	COG0513	Belongs to the DEAD box helicase family
H9Q12_RS03770	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H9Q12_RS03775	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H9Q12_RS03780	COG2384	SAM-dependent methyltransferase
H9Q12_RS03785	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H9Q12_RS03790	COG0358	DNA primase activity
H9Q12_RS03795	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H9Q12_RS03800	COG0517	IMP dehydrogenase activity
H9Q12_RS03805	COG0423	glycine-tRNA ligase activity
H9Q12_RS03810	COG1381	Involved in DNA repair and RecF pathway recombination
H9Q12_RS03815	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H9Q12_RS03825	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H9Q12_RS03835	COG1702	phosphate starvation-inducible protein PhoH
H9Q12_RS03845	COG4864	UPF0365 protein
H9Q12_RS03850	COG1030	water channel activity
H9Q12_RS03865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H9Q12_RS03870	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H9Q12_RS03875	COG2264	protein methyltransferase activity
H9Q12_RS03880	COG0484	heat shock protein binding
H9Q12_RS03885	COG0443	Heat shock 70 kDa protein
H9Q12_RS03900	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H9Q12_RS03910	COG0268	Binds directly to 16S ribosomal RNA
H9Q12_RS03915	COG1466	dna polymerase III delta subunit
H9Q12_RS03920	COG2333	competence protein COMEC
H9Q12_RS03920	COG0658	competence protein
H9Q12_RS03925	COG2131	deaminase
H9Q12_RS03930	COG1596	polysaccharide export
H9Q12_RS03930	COG1555	photosystem II stabilization
H9Q12_RS03935	COG2226	methyltransferase
H9Q12_RS03940	COG0799	negative regulation of ribosome biogenesis
H9Q12_RS03945	COG1713	HD superfamily hydrolase involved in NAD metabolism
H9Q12_RS03955	COG1534	Rna-binding protein
H9Q12_RS03960	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H9Q12_RS03965	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
H9Q12_RS03970	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
H9Q12_RS03975	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H9Q12_RS03980	COG1914	H( )-stimulated, divalent metal cation uptake system
H9Q12_RS03985	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H9Q12_RS03990	COG0439	Biotin carboxylase
H9Q12_RS03995	COG0511	ligase activity, forming carbon-carbon bonds
H9Q12_RS04000	COG1984	allophanate hydrolase subunit 2
H9Q12_RS04005	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H9Q12_RS04015	COG0572	uridine kinase
H9Q12_RS04020	COG0826	peptidase U32
H9Q12_RS04025	COG0826	peptidase U32
H9Q12_RS04030	COG4122	O-methyltransferase activity
H9Q12_RS04035	COG3906	Belongs to the UPF0473 family
H9Q12_RS04040	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H9Q12_RS04045	COG4472	Bacterial protein of unknown function (DUF965)
H9Q12_RS04050	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H9Q12_RS04055	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H9Q12_RS04065	COG0482	sulfurtransferase activity
H9Q12_RS04070	COG1104	cysteine desulfurase activity
H9Q12_RS04075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H9Q12_RS04090	COG1959	2 iron, 2 sulfur cluster binding
H9Q12_RS04095	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H9Q12_RS04100	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H9Q12_RS04110	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H9Q12_RS04120	COG0860	N-Acetylmuramoyl-L-alanine amidase
H9Q12_RS04125	COG1490	D-aminoacyl-tRNA deacylase activity
H9Q12_RS04135	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H9Q12_RS04140	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
H9Q12_RS04140	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H9Q12_RS04145	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H9Q12_RS04145	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H9Q12_RS04150	COG1862	Preprotein translocase
H9Q12_RS04160	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H9Q12_RS04170	COG0632	four-way junction helicase activity
H9Q12_RS04180	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H9Q12_RS04190	COG2868	ribosomal protein
H9Q12_RS04225	COG2003	Belongs to the UPF0758 family
H9Q12_RS04235	COG0285	dihydrofolate synthase activity
H9Q12_RS04240	COG0525	valine-tRNA ligase activity
H9Q12_RS04245	COG2818	Glycosylase
H9Q12_RS04255	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H9Q12_RS04270	COG0181	hydroxymethylbilane synthase activity
H9Q12_RS04280	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H9Q12_RS04285	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H9Q12_RS04295	COG0544	peptidyl-prolyl cis-trans isomerase activity
H9Q12_RS04310	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H9Q12_RS04315	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H9Q12_RS04320	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H9Q12_RS04330	COG0833	amino acid
H9Q12_RS04340	COG1484	DNA-dependent DNA replication
H9Q12_RS04345	COG3611	Membrane attachment protein
H9Q12_RS04360	COG0237	dephospho-CoA kinase activity
H9Q12_RS04370	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9Q12_RS04370	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9Q12_RS04375	COG5002	protein histidine kinase activity
H9Q12_RS04380	COG0745	RESPONSE REGULATOR receiver
H9Q12_RS04385	COG0538	isocitrate dehydrogenase activity
H9Q12_RS04390	COG0372	Belongs to the citrate synthase family
H9Q12_RS04395	COG0469	pyruvate kinase activity
H9Q12_RS04400	COG0205	6-phosphofructokinase activity
H9Q12_RS04405	COG0825	malonyl-CoA metabolic process
H9Q12_RS04410	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H9Q12_RS04415	COG0281	malic enzyme
H9Q12_RS04420	COG0587	DNA-directed DNA polymerase activity
H9Q12_RS04425	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H9Q12_RS04430	COG4109	DRTGG domain
H9Q12_RS04440	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H9Q12_RS04445	COG0006	proline dipeptidase activity
H9Q12_RS04455	COG0686	Belongs to the AlaDH PNT family
H9Q12_RS04460	COG0589	response to stress
H9Q12_RS04465	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H9Q12_RS04470	COG0827	DNA restriction-modification system
H9Q12_RS04475	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H9Q12_RS04480	COG1714	RDD family
H9Q12_RS04485	COG0616	signal peptide processing
H9Q12_RS04495	COG0301	tRNA thio-modification
H9Q12_RS04500	COG1104	cysteine desulfurase activity
H9Q12_RS04505	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
H9Q12_RS04510	COG1956	GAF domain-containing protein
H9Q12_RS04515	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H9Q12_RS04545	COG0456	acetyltransferase
H9Q12_RS04580	COG1764	response to oxidative stress
H9Q12_RS04585	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
H9Q12_RS04590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H9Q12_RS04600	COG0204	Acyl-transferase
H9Q12_RS04605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H9Q12_RS04615	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H9Q12_RS04620	COG2759	Belongs to the formate--tetrahydrofolate ligase family
H9Q12_RS04625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H9Q12_RS04630	COG0454	-acetyltransferase
H9Q12_RS04640	COG1609	Transcriptional regulator
H9Q12_RS04645	COG1605	Chorismate mutase
H9Q12_RS04645	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
H9Q12_RS04655	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
H9Q12_RS04660	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H9Q12_RS04665	COG1674	ftsk spoiiie
H9Q12_RS04670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H9Q12_RS04675	COG4848	Belongs to the UPF0354 family
H9Q12_RS04680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9Q12_RS04685	COG1363	Peptidase, m42
H9Q12_RS04695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9Q12_RS04700	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H9Q12_RS04705	COG0510	thiamine kinase activity
H9Q12_RS04710	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H9Q12_RS04715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9Q12_RS04725	COG1187	pseudouridine synthase activity
H9Q12_RS04730	COG2244	polysaccharide biosynthetic process
H9Q12_RS04735	COG2081	HI0933 family
H9Q12_RS04740	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H9Q12_RS04745	COG0495	leucyl-tRNA aminoacylation
H9Q12_RS04750	COG2814	Major facilitator Superfamily
H9Q12_RS04755	COG1242	4 iron, 4 sulfur cluster binding
H9Q12_RS04760	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
H9Q12_RS04770	COG0039	L-malate dehydrogenase activity
H9Q12_RS04775	COG2267	carboxylic ester hydrolase activity
H9Q12_RS04790	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H9Q12_RS04795	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H9Q12_RS04795	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H9Q12_RS04800	COG0307	riboflavin synthase, alpha
H9Q12_RS04805	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H9Q12_RS04805	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H9Q12_RS04815	COG4193	domain, Protein
H9Q12_RS04815	COG5632	N-Acetylmuramoyl-L-alanine amidase
H9Q12_RS04815	COG3266	domain, Protein
H9Q12_RS04840	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H9Q12_RS04850	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H9Q12_RS04855	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H9Q12_RS04860	COG0656	L-ascorbic acid biosynthetic process
H9Q12_RS04875	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H9Q12_RS04880	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H9Q12_RS04885	COG1506	peptidase
H9Q12_RS04890	COG0494	nUDIX hydrolase
H9Q12_RS04895	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H9Q12_RS04915	COG0235	Class ii aldolase
H9Q12_RS04920	COG3623	hexulose-6-phosphate isomerase
H9Q12_RS04940	COG3037	sugar-specific permease SgaT UlaA
H9Q12_RS05005	COG4824	toxin secretion phage lysis holin
H9Q12_RS05265	COG0582	viral genome integration into host DNA
H9Q12_RS05315	COG3545	Serine hydrolase
H9Q12_RS05320	COG3344	reverse transcriptase
H9Q12_RS05325	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
H9Q12_RS05335	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H9Q12_RS05345	COG3344	reverse transcriptase
H9Q12_RS05350	COG4473	ABC transporter
H9Q12_RS05355	COG1131	(ABC) transporter
H9Q12_RS05360	COG0537	adenosine 5'-monophosphoramidase activity
H9Q12_RS05370	COG1846	Transcriptional regulator
H9Q12_RS05385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H9Q12_RS05390	COG3481	metal-dependent phosphohydrolase, HD sub domain
H9Q12_RS05400	COG0420	3'-5' exonuclease activity
H9Q12_RS05405	COG3679	Belongs to the UPF0342 family
H9Q12_RS05410	COG4399	Belongs to the UPF0754 family
H9Q12_RS05415	COG3344	reverse transcriptase
H9Q12_RS05430	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H9Q12_RS05435	COG2197	response regulator
H9Q12_RS05440	COG4585	Histidine kinase
H9Q12_RS05440	COG2203	Gaf domain
H9Q12_RS05445	COG0564	pseudouridine synthase activity
H9Q12_RS05450	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H9Q12_RS05455	COG0248	Ppx GppA phosphatase
H9Q12_RS05460	COG0114	fumarate hydratase activity
H9Q12_RS05475	COG0363	glucosamine-6-phosphate deaminase activity
H9Q12_RS05485	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H9Q12_RS05490	COG1126	abc transporter atp-binding protein
H9Q12_RS05495	COG0765	amino acid transport
H9Q12_RS05720	COG0735	belongs to the Fur family
H9Q12_RS05730	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H9Q12_RS05735	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H9Q12_RS05740	COG4129	membrane
H9Q12_RS05745	COG0069	glutamate synthase activity
H9Q12_RS05755	COG3557	Belongs to the UPF0374 family
H9Q12_RS05760	COG1194	a g-specific adenine glycosylase
H9Q12_RS05765	COG1988	membrane-bound metal-dependent
H9Q12_RS05775	COG1388	LysM domain
H9Q12_RS05775	COG1134	teichoic acid transport
H9Q12_RS05785	COG2137	regulation of response to DNA damage stimulus
H9Q12_RS05790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H9Q12_RS05795	COG0028	Belongs to the TPP enzyme family
H9Q12_RS05800	COG0693	protein deglycase activity
H9Q12_RS05810	COG0535	radical SAM domain protein
H9Q12_RS05815	COG1607	acyl-coa hydrolase
H9Q12_RS05820	COG2309	aminopeptidase activity
H9Q12_RS05825	COG4840	Belongs to the UPF0435 family
H9Q12_RS05840	COG1295	ribonuclease BN
H9Q12_RS05845	COG0288	reversible hydration of carbon dioxide
H9Q12_RS05870	COG0024	Methionine aminopeptidase
H9Q12_RS05875	COG4129	membrane
H9Q12_RS05890	COG1528	Iron-storage protein
H9Q12_RS05900	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H9Q12_RS05925	COG1597	lipid kinase activity
H9Q12_RS05930	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H9Q12_RS05940	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H9Q12_RS05945	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H9Q12_RS05950	COG4851	CamS sex pheromone cAM373 precursor
H9Q12_RS05955	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H9Q12_RS05960	COG0210	DNA helicase
H9Q12_RS05965	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
H9Q12_RS05970	COG4496	protein, YerC YecD
H9Q12_RS05975	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H9Q12_RS05985	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
H9Q12_RS05995	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H9Q12_RS06005	COG1605	Chorismate mutase
H9Q12_RS06005	COG0077	Prephenate dehydratase
H9Q12_RS06015	COG1335	isochorismatase
H9Q12_RS06020	COG1227	inorganic diphosphatase activity
H9Q12_RS06030	COG1012	belongs to the aldehyde dehydrogenase family
H9Q12_RS06035	COG2706	6-phosphogluconolactonase activity
H9Q12_RS06070	COG2610	gluconate transmembrane transporter activity
H9Q12_RS06075	COG1070	Carbohydrate kinase
H9Q12_RS06080	COG1802	Transcriptional regulator
H9Q12_RS06090	COG1131	(ABC) transporter
H9Q12_RS06110	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H9Q12_RS06115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9Q12_RS06120	COG1404	Belongs to the peptidase S8 family
H9Q12_RS06165	COG4512	PFAM Accessory gene regulator B
H9Q12_RS06185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9Q12_RS06190	COG1621	beta-fructofuranosidase activity
H9Q12_RS06195	COG1609	Transcriptional regulator
H9Q12_RS06200	COG2124	cytochrome p450
H9Q12_RS06210	COG1846	Transcriptional regulator
H9Q12_RS06215	COG2814	Major facilitator Superfamily
H9Q12_RS06220	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
H9Q12_RS06225	COG0488	(ABC) transporter
H9Q12_RS06230	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H9Q12_RS06240	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H9Q12_RS06245	COG0456	acetyltransferase
H9Q12_RS06250	COG1214	PFAM Peptidase M22, glycoprotease
H9Q12_RS06255	COG0802	atpase or kinase
H9Q12_RS06260	COG0129	dihydroxy-acid dehydratase activity
H9Q12_RS06265	COG0028	Belongs to the TPP enzyme family
H9Q12_RS06275	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H9Q12_RS06280	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H9Q12_RS06290	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H9Q12_RS06335	COG3091	SprT-like family
H9Q12_RS06340	COG2183	response to ionizing radiation
H9Q12_RS06345	COG1191	sigma factor activity
H9Q12_RS06355	COG1366	Belongs to the anti-sigma-factor antagonist family
H9Q12_RS06360	COG2208	phosphoserine phosphatase activity
H9Q12_RS06365	COG2337	Toxic component of a toxin-antitoxin (TA) module
H9Q12_RS06375	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H9Q12_RS06380	COG0736	holo-[acyl-carrier-protein] synthase activity
H9Q12_RS06385	COG3402	PFAM membrane-flanked domain
H9Q12_RS06400	COG0513	Belongs to the DEAD box helicase family
H9Q12_RS06405	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H9Q12_RS06410	COG1181	Belongs to the D-alanine--D-alanine ligase family
H9Q12_RS06415	COG0772	Belongs to the SEDS family
H9Q12_RS06430	COG2217	Heavy metal translocating P-type atpase
H9Q12_RS06445	COG1937	Protein conserved in bacteria
H9Q12_RS06450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H9Q12_RS06455	COG1418	mRNA catabolic process
H9Q12_RS06460	COG0706	membrane insertase activity
H9Q12_RS06465	COG0352	thiamine-phosphate diphosphorylase activity
H9Q12_RS06470	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
H9Q12_RS06480	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H9Q12_RS06495	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H9Q12_RS06525	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H9Q12_RS06535	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H9Q12_RS06545	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H9Q12_RS06550	COG0356	it plays a direct role in the translocation of protons across the membrane
H9Q12_RS06560	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H9Q12_RS06565	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H9Q12_RS06570	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H9Q12_RS06575	COG4475	Protein of unknown function (DUF436)
H9Q12_RS06580	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H9Q12_RS06585	COG0009	L-threonylcarbamoyladenylate synthase
H9Q12_RS06590	COG2890	protein-(glutamine-N5) methyltransferase activity
H9Q12_RS06595	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H9Q12_RS06605	COG0254	rRNA binding
H9Q12_RS06610	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H9Q12_RS06620	COG1733	regulation of RNA biosynthetic process
H9Q12_RS06625	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H9Q12_RS06630	COG0191	fructose-bisphosphate aldolase activity
H9Q12_RS06635	COG4821	SIS domain
H9Q12_RS06640	COG2271	Major facilitator Superfamily
H9Q12_RS06645	COG0504	CTP synthase activity
H9Q12_RS06655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H9Q12_RS06665	COG5146	pantothenate kinase activity
H9Q12_RS06700	COG0813	purine-nucleoside phosphorylase activity
H9Q12_RS06710	COG1757	Na H antiporter
H9Q12_RS06725	COG1482	cell wall glycoprotein biosynthetic process
H9Q12_RS06730	COG2186	Transcriptional regulator
H9Q12_RS06740	COG0561	phosphatase activity
H9Q12_RS06745	COG1119	ATPase activity
H9Q12_RS06775	COG3711	transcriptional antiterminator
H9Q12_RS06790	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H9Q12_RS06855	COG0489	protein tyrosine kinase activity
H9Q12_RS06860	COG2814	Major facilitator Superfamily
H9Q12_RS06880	COG1272	protein, Hemolysin III
H9Q12_RS06885	COG4284	Utp--glucose-1-phosphate uridylyltransferase
H9Q12_RS06890	COG1988	membrane-bound metal-dependent
H9Q12_RS06900	COG3314	Sporulation integral membrane protein YlbJ
H9Q12_RS06905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9Q12_RS06910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9Q12_RS06915	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H9Q12_RS06920	COG3457	Alanine racemase
H9Q12_RS06925	COG4264	IucA IucC family
H9Q12_RS06930	COG2814	Major facilitator Superfamily
H9Q12_RS06935	COG4264	IucA IucC family
H9Q12_RS06940	COG2814	Major facilitator Superfamily
H9Q12_RS06945	COG1302	Protein conserved in bacteria
H9Q12_RS06960	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H9Q12_RS06970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H9Q12_RS06975	COG0488	(ABC) transporter
H9Q12_RS06985	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9Q12_RS06985	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
H9Q12_RS06995	COG3684	Belongs to the aldolase LacD family
H9Q12_RS07010	COG1349	DNA-binding transcription factor activity
H9Q12_RS07015	COG1335	isochorismatase
H9Q12_RS07030	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H9Q12_RS07035	COG0101	tRNA pseudouridine synthase activity
H9Q12_RS07045	COG1122	ATPase activity
H9Q12_RS07050	COG1122	ATPase activity
H9Q12_RS07055	COG0203	ribosomal protein L17
H9Q12_RS07060	COG0202	RNA polymerase activity
H9Q12_RS07065	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H9Q12_RS07075	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H9Q12_RS07090	COG0201	protein transport
H9Q12_RS07100	COG1841	ribosomal large subunit assembly
H9Q12_RS07105	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H9Q12_RS07115	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H9Q12_RS07120	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H9Q12_RS07125	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H9Q12_RS07140	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H9Q12_RS07150	COG0255	Belongs to the universal ribosomal protein uL29 family
H9Q12_RS07155	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H9Q12_RS07160	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H9Q12_RS07165	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H9Q12_RS07170	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H9Q12_RS07175	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H9Q12_RS07180	COG0089	rRNA binding
H9Q12_RS07185	COG0088	Forms part of the polypeptide exit tunnel
H9Q12_RS07190	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H9Q12_RS07210	COG2252	PERMEase
H9Q12_RS07240	COG0436	Aminotransferase
H9Q12_RS07245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9Q12_RS07250	COG2348	transferase activity, transferring amino-acyl groups
H9Q12_RS07275	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H9Q12_RS07280	COG0746	molybdenum cofactor guanylyltransferase activity
H9Q12_RS07290	COG0314	molybdopterin synthase activity
H9Q12_RS07310	COG0521	Mo-molybdopterin cofactor biosynthetic process
H9Q12_RS07315	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H9Q12_RS07320	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H9Q12_RS07325	COG4149	molybdate abc transporter
H9Q12_RS07335	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
H9Q12_RS07340	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H9Q12_RS07345	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H9Q12_RS07350	COG1609	Transcriptional regulator
H9Q12_RS07365	COG1268	BioY protein
H9Q12_RS07375	COG2186	Transcriptional regulator
H9Q12_RS07385	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H9Q12_RS07390	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
H9Q12_RS07395	COG2832	Protein of unknown function (DUF454)
H9Q12_RS07400	COG1960	acyl-CoA dehydrogenase activity
H9Q12_RS07420	COG3942	CHAP domain
H9Q12_RS07430	COG1757	Na H antiporter
H9Q12_RS07440	COG3942	CHAP domain
H9Q12_RS07445	COG2076	Multidrug Resistance protein
H9Q12_RS07450	COG2076	Multidrug Resistance protein
H9Q12_RS07455	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H9Q12_RS07480	COG3383	formate dehydrogenase (NAD+) activity
H9Q12_RS07485	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
H9Q12_RS07500	COG1316	TRANSCRIPTIONal
H9Q12_RS07525	COG1113	amino acid transport
H9Q12_RS07550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H9Q12_RS07555	COG0346	lactoylglutathione lyase activity
H9Q12_RS07565	COG0385	Bile acid
H9Q12_RS07585	COG1473	amidohydrolase
H9Q12_RS07590	COG0659	secondary active sulfate transmembrane transporter activity
H9Q12_RS07595	COG1228	amidohydrolase
H9Q12_RS07600	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H9Q12_RS07605	COG3314	Sporulation integral membrane protein YlbJ
H9Q12_RS07610	COG0583	DNA-binding transcription factor activity
H9Q12_RS07615	COG1266	CAAX protease self-immunity
H9Q12_RS07625	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H9Q12_RS07630	COG2258	MOSC domain
H9Q12_RS07635	COG2017	converts alpha-aldose to the beta-anomer
H9Q12_RS07640	COG1742	UPF0060 membrane protein
H9Q12_RS07645	COG1668	transmembrane transport
H9Q12_RS07650	COG4152	abc transporter atp-binding protein
H9Q12_RS07655	COG3152	Membrane
H9Q12_RS07660	COG2094	Belongs to the DNA glycosylase MPG family
H9Q12_RS07665	COG1757	Na H antiporter
H9Q12_RS07685	COG3250	beta-galactosidase activity
H9Q12_RS07690	COG2207	Transcriptional regulator
H9Q12_RS07695	COG0786	glutamate:sodium symporter activity
H9Q12_RS07700	COG0523	cobalamin synthesis protein
H9Q12_RS07705	COG1304	FMN binding
H9Q12_RS07725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9Q12_RS07735	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H9Q12_RS07745	COG4640	response to antibiotic
H9Q12_RS07770	COG0577	efflux transmembrane transporter activity
H9Q12_RS07785	COG0579	oxidoreductase
H9Q12_RS07790	COG0438	transferase activity, transferring glycosyl groups
H9Q12_RS07795	COG1620	l-lactate permease
H9Q12_RS07810	COG0604	alcohol dehydrogenase
H9Q12_RS07815	COG2814	Major facilitator Superfamily
H9Q12_RS07820	COG0492	ferredoxin-NADP+ reductase activity
H9Q12_RS07840	COG1283	sodium-dependent phosphate transmembrane transporter activity
H9Q12_RS07855	COG1263	PTS System
H9Q12_RS07855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9Q12_RS07865	COG2807	transmembrane transport
H9Q12_RS07875	COG0697	spore germination
H9Q12_RS07880	COG1363	Peptidase, m42
H9Q12_RS07885	COG0039	L-malate dehydrogenase activity
H9Q12_RS07895	COG4187	Peptidase family M20/M25/M40
H9Q12_RS07900	COG3344	reverse transcriptase
H9Q12_RS07905	COG2223	nitrite transmembrane transporter activity
H9Q12_RS07910	COG2197	response regulator
H9Q12_RS07915	COG4585	Histidine kinase
H9Q12_RS07925	COG2181	nitrate reductase activity
H9Q12_RS07935	COG1140	nitrate reductase beta subunit
H9Q12_RS07940	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
H9Q12_RS07950	COG0737	Belongs to the 5'-nucleotidase family
H9Q12_RS07955	COG1648	precorrin-2 dehydrogenase activity
H9Q12_RS07955	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H9Q12_RS07960	COG2146	nitrite reductase [NAD(P)H] activity
H9Q12_RS07965	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H9Q12_RS07970	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H9Q12_RS07970	COG1648	precorrin-2 dehydrogenase activity
H9Q12_RS07980	COG0454	-acetyltransferase
H9Q12_RS07985	COG2116	formate transmembrane transporter activity
H9Q12_RS07990	COG0471	metal ion transport
H9Q12_RS08020	COG1760	l-serine dehydratase
H9Q12_RS08025	COG1760	l-serine dehydratase
H9Q12_RS08035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9Q12_RS08040	COG0601	transmembrane transport
H9Q12_RS08045	COG4608	Belongs to the ABC transporter superfamily
H9Q12_RS08050	COG0444	Belongs to the ABC transporter superfamily
H9Q12_RS08055	COG4166	transmembrane transport
H9Q12_RS08060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9Q12_RS08065	COG0601	transmembrane transport
H9Q12_RS08070	COG4608	Belongs to the ABC transporter superfamily
H9Q12_RS08075	COG0444	Belongs to the ABC transporter superfamily
H9Q12_RS08080	COG4166	transmembrane transport
H9Q12_RS08085	COG0702	epimerase
H9Q12_RS08090	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H9Q12_RS08110	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
H9Q12_RS08120	COG1929	Belongs to the glycerate kinase type-1 family
H9Q12_RS08125	COG3764	Sortase (surface protein transpeptidase)
H9Q12_RS08130	COG2271	Major facilitator Superfamily
H9Q12_RS08135	COG2814	Major facilitator Superfamily
H9Q12_RS08140	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
H9Q12_RS08145	COG1115	amino acid carrier protein
H9Q12_RS08150	COG3871	stress protein (general stress protein 26)
H9Q12_RS08205	COG0741	lytic transglycosylase activity
H9Q12_RS08205	COG0791	NLP P60 protein
H9Q12_RS08235	COG2946	Replication initiation factor
H9Q12_RS08245	COG1674	ftsk spoiiie
H9Q12_RS08265	COG1132	(ABC) transporter
H9Q12_RS08270	COG1132	(ABC) transporter
H9Q12_RS08275	COG0247	lactate metabolic process
H9Q12_RS08280	COG0277	FAD linked oxidase domain protein
H9Q12_RS08300	COG0159	tryptophan synthase activity
H9Q12_RS08305	COG0133	tryptophan synthase activity
H9Q12_RS08315	COG0134	indole-3-glycerol-phosphate synthase activity
H9Q12_RS08325	COG0512	Glutamine amidotransferase of anthranilate synthase
H9Q12_RS08330	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H9Q12_RS08335	COG3961	Belongs to the TPP enzyme family
H9Q12_RS08340	COG2855	membrane
H9Q12_RS08345	COG3835	regulator
H9Q12_RS08360	COG1028	Short-chain dehydrogenase reductase Sdr
H9Q12_RS08400	COG2357	RelA SpoT domain protein
H9Q12_RS08405	COG0778	Nitroreductase
H9Q12_RS08410	COG1846	Transcriptional regulator
H9Q12_RS08425	COG1346	cytolysis
H9Q12_RS08435	COG0583	DNA-binding transcription factor activity
H9Q12_RS08460	COG1141	Ferredoxin
H9Q12_RS08470	COG0523	cobalamin synthesis protein
H9Q12_RS08475	COG0717	Belongs to the dCTP deaminase family
H9Q12_RS08480	COG0804	urea catabolic process
H9Q12_RS08485	COG0832	Belongs to the urease beta subunit family
H9Q12_RS08495	COG4413	Urea transporter
H9Q12_RS08515	COG0577	efflux transmembrane transporter activity
H9Q12_RS08520	COG1136	(ABC) transporter
H9Q12_RS08545	COG3001	Fructosamine kinase
H9Q12_RS08550	COG0778	Nitroreductase
H9Q12_RS08555	COG3181	Tripartite tricarboxylate transporter family receptor
H9Q12_RS08575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H9Q12_RS08580	COG0438	transferase activity, transferring glycosyl groups
H9Q12_RS08585	COG0463	Glycosyl transferase, family 2
H9Q12_RS08585	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H9Q12_RS08590	COG0463	Glycosyl transferase, family 2
H9Q12_RS08590	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H9Q12_RS08615	COG0747	negative chemotaxis
H9Q12_RS08620	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H9Q12_RS08625	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H9Q12_RS08640	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H9Q12_RS08650	COG3942	CHAP domain
H9Q12_RS08650	COG1705	Flagellar rod assembly protein muramidase FlgJ
H9Q12_RS08660	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9Q12_RS08660	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9Q12_RS08660	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9Q12_RS08665	COG0789	Transcriptional regulator
H9Q12_RS08670	COG0596	Alpha beta hydrolase
H9Q12_RS08685	COG1012	belongs to the aldehyde dehydrogenase family
H9Q12_RS08690	COG2824	Alkylphosphonate utilization operon protein PhnA
H9Q12_RS08695	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
H9Q12_RS08700	COG1461	Dihydroxyacetone kinase
H9Q12_RS08705	COG2376	Dihydroxyacetone kinase
H9Q12_RS08740	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H9Q12_RS08745	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H9Q12_RS08750	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H9Q12_RS08755	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H9Q12_RS08770	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H9Q12_RS08775	COG0107	imidazoleglycerol-phosphate synthase activity
H9Q12_RS08785	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H9Q12_RS08790	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
H9Q12_RS08795	COG1012	belongs to the aldehyde dehydrogenase family
H9Q12_RS08800	COG1510	regulation of RNA biosynthetic process
H9Q12_RS08810	COG1914	H( )-stimulated, divalent metal cation uptake system
H9Q12_RS08840	COG1785	Belongs to the alkaline phosphatase family
H9Q12_RS08855	COG1396	sequence-specific DNA binding
H9Q12_RS08860	COG2807	transmembrane transport
H9Q12_RS08865	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
H9Q12_RS08870	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H9Q12_RS08910	COG1957	nucleoside hydrolase
H9Q12_RS08915	COG3250	beta-galactosidase activity
H9Q12_RS08920	COG2211	Major facilitator Superfamily
H9Q12_RS08925	COG0477	Major facilitator Superfamily
H9Q12_RS08930	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H9Q12_RS08935	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H9Q12_RS08945	COG2972	Histidine kinase
H9Q12_RS08950	COG4753	response regulator
H9Q12_RS08950	COG2207	Transcriptional regulator
H9Q12_RS08975	COG3443	Belongs to the bacterial solute-binding protein 9 family
H9Q12_RS08975	COG0803	Belongs to the bacterial solute-binding protein 9 family
H9Q12_RS08985	COG1942	4-Oxalocrotonate Tautomerase
H9Q12_RS08990	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H9Q12_RS09010	COG1328	CTP reductase activity
H9Q12_RS09020	COG3037	sugar-specific permease SgaT UlaA
H9Q12_RS09030	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9Q12_RS09035	COG3711	transcriptional antiterminator
H9Q12_RS09060	COG1869	D-ribose catabolic process
H9Q12_RS09065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9Q12_RS09070	COG1609	Transcriptional regulator
H9Q12_RS09100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H9Q12_RS09110	COG2814	Major facilitator Superfamily
H9Q12_RS09120	COG0318	PFAM AMP-dependent synthetase and ligase
H9Q12_RS09135	COG0183	Belongs to the thiolase family
H9Q12_RS09140	COG0438	transferase activity, transferring glycosyl groups
H9Q12_RS09160	COG1073	alpha beta
H9Q12_RS09180	COG0579	oxidoreductase
H9Q12_RS09205	COG1755	Isoprenylcysteine carboxyl methyltransferase
H9Q12_RS09215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9Q12_RS09225	COG1136	(ABC) transporter
H9Q12_RS09250	COG0436	Aminotransferase
H9Q12_RS09260	COG0783	Belongs to the Dps family
H9Q12_RS09270	COG0753	catalase activity
H9Q12_RS09275	COG2318	DinB family
H9Q12_RS09290	COG0076	glutamate decarboxylase activity
H9Q12_RS09305	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H9Q12_RS09350	COG0156	8-amino-7-oxononanoate synthase activity
H9Q12_RS09355	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H9Q12_RS09360	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H9Q12_RS09365	COG1620	l-lactate permease
H9Q12_RS09380	COG1063	alcohol dehydrogenase
H9Q12_RS09400	COG3314	Sporulation integral membrane protein YlbJ
H9Q12_RS09420	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H9Q12_RS09430	COG3716	PTS system mannose fructose sorbose family IID component
H9Q12_RS09435	COG3715	PTS system
H9Q12_RS09440	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9Q12_RS09440	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9Q12_RS09455	COG1105	Belongs to the carbohydrate kinase PfkB family
H9Q12_RS09460	COG2222	sugar isomerase
H9Q12_RS09465	COG2188	Transcriptional regulator
H9Q12_RS09470	COG0366	Alpha amylase catalytic
H9Q12_RS09480	COG1131	(ABC) transporter
H9Q12_RS09510	COG0346	lactoylglutathione lyase activity
H9Q12_RS09520	COG0490	domain, Protein
H9Q12_RS09525	COG0475	glutathione-regulated potassium exporter activity
H9Q12_RS09530	COG3842	ATPase activity
H9Q12_RS09540	COG1175	transmembrane transport
H9Q12_RS09545	COG3833	ABC-type maltose transport systems, permease component
H9Q12_RS09555	COG0366	Alpha amylase catalytic
H9Q12_RS09565	COG0673	inositol 2-dehydrogenase activity
H9Q12_RS09575	COG1609	Transcriptional regulator
H9Q12_RS09620	COG0431	NADPH-dependent FMN reductase
H9Q12_RS09640	COG1131	(ABC) transporter
H9Q12_RS09645	COG0842	Transport permease protein
H9Q12_RS09650	COG2203	Gaf domain
H9Q12_RS09650	COG4585	Histidine kinase
H9Q12_RS09655	COG2197	response regulator
H9Q12_RS09670	COG2235	arginine
H9Q12_RS09690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9Q12_RS09695	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H9Q12_RS09705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9Q12_RS09725	COG2130	NADP-dependent
H9Q12_RS09730	COG0702	epimerase
H9Q12_RS09745	COG0415	Belongs to the DNA photolyase family
H9Q12_RS09755	COG2723	6-phospho-beta-galactosidase activity
H9Q12_RS09760	COG2188	Transcriptional regulator
H9Q12_RS09770	COG2217	Heavy metal translocating P-type atpase
H9Q12_RS09775	COG0531	amino acid
H9Q12_RS09795	COG2311	Membrane
H9Q12_RS09830	COG1332	CRISPR-associated RAMP protein, Csm5 family
H9Q12_RS09835	COG1567	CRISPR-associated RAMP protein, Csm4 family
H9Q12_RS09840	COG1337	RAMP superfamily
H9Q12_RS09845	COG1421	Csm2 Type III-A
H9Q12_RS09850	COG1353	crispr-associated protein
H9Q12_RS09855	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
H9Q12_RS09895	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H9Q12_RS09945	COG2030	dehydratase
H9Q12_RS09950	COG0584	glycerophosphoryl diester phosphodiesterase
H9Q12_RS09995	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9Q12_RS09995	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9Q12_RS10020	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H9Q12_RS10030	COG4863	YycH protein
H9Q12_RS10035	COG5002	protein histidine kinase activity
H9Q12_RS10040	COG0745	RESPONSE REGULATOR receiver
H9Q12_RS10060	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H9Q12_RS10065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H9Q12_RS10070	COG0305	Participates in initiation and elongation during chromosome replication
H9Q12_RS10075	COG0359	binds to the 23S rRNA
H9Q12_RS10080	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
H9Q12_RS10085	COG4241	membrane
H9Q12_RS10090	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H9Q12_RS10100	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H9Q12_RS10110	COG2986	histidine ammonia-lyase
H9Q12_RS10115	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H9Q12_RS10125	COG0187	DNA topoisomerase II activity
H9Q12_RS10130	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H9Q12_RS10135	COG2501	S4 domain
H9Q12_RS10145	COG0592	DNA-directed DNA polymerase activity
H9Q12_RS10150	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H9Q12_RS10160	COG0594	ribonuclease P activity
H9Q12_RS10165	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H9Q12_RS10170	COG0445	tRNA wobble uridine modification
H9Q12_RS10175	COG0357	Ribosomal RNA small subunit methyltransferase G
H9Q12_RS10200	COG0400	carboxylic ester hydrolase activity
H9Q12_RS10205	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H9Q12_RS10210	COG0346	lactoylglutathione lyase activity
H9Q12_RS10215	COG1846	Transcriptional regulator
H9Q12_RS10220	COG2388	GCN5-related N-acetyl-transferase
H9Q12_RS10230	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
H9Q12_RS10235	COG0830	nickel cation binding
H9Q12_RS10245	COG0829	nickel cation binding
H9Q12_RS10255	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H9Q12_RS10255	COG0646	methionine synthase
H9Q12_RS10260	COG0626	cystathionine gamma-synthase activity
H9Q12_RS10265	COG0626	cystathionine gamma-synthase activity
H9Q12_RS10270	COG1475	DNA binding
H9Q12_RS10275	COG0668	transmembrane transport
H9Q12_RS10280	COG4481	Protein conserved in bacteria
H9Q12_RS10285	COG0012	GTP binding
H9Q12_RS10290	COG1131	(ABC) transporter
H9Q12_RS10295	COG1668	transmembrane transport
H9Q12_RS10305	COG0360	Binds together with S18 to 16S ribosomal RNA
H9Q12_RS10315	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H9Q12_RS10325	COG0753	catalase activity
H9Q12_RS10330	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H9Q12_RS10335	COG1464	Belongs to the NlpA lipoprotein family
H9Q12_RS10340	COG2011	ABC-type metal ion transport system permease component
H9Q12_RS10345	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H9Q12_RS10355	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H9Q12_RS10370	COG0450	alkyl hydroperoxide reductase
H9Q12_RS10375	COG0778	Nitroreductase
H9Q12_RS10400	COG1823	symporter activity
H9Q12_RS10405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H9Q12_RS10410	COG5183	chlorophyll binding
H9Q12_RS10425	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H9Q12_RS10430	COG2233	PERMEase
H9Q12_RS10435	COG0516	GMP reductase activity
H9Q12_RS10435	COG0517	IMP dehydrogenase activity
H9Q12_RS10440	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H9Q12_RS10440	COG0519	Catalyzes the synthesis of GMP from XMP
H9Q12_RS10460	COG1525	nuclease
H9Q12_RS10480	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H9Q12_RS10505	COG0747	negative chemotaxis
H9Q12_RS10510	COG0601	transmembrane transport
H9Q12_RS10515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H9Q12_RS10520	COG0444	Belongs to the ABC transporter superfamily
H9Q12_RS10525	COG1124	(ABC) transporter
H9Q12_RS10550	COG3682	Transcriptional regulator
H9Q12_RS10565	COG3344	reverse transcriptase
H9Q12_RS10575	COG2814	Major facilitator Superfamily
H9Q12_RS10580	COG0730	response to heat
H9Q12_RS10585	COG1937	Protein conserved in bacteria
H9Q12_RS10590	COG2210	Belongs to the sulfur carrier protein TusA family
H9Q12_RS10610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9Q12_RS10610	COG1263	PTS System
H9Q12_RS10615	COG1486	melibiose metabolic process
H9Q12_RS10625	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H9Q12_RS10670	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H9Q12_RS10670	COG0574	Belongs to the PEP-utilizing enzyme family
H9Q12_RS10675	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H9Q12_RS10690	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H9Q12_RS10695	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H9Q12_RS10705	COG2205	protein histidine kinase activity
H9Q12_RS10710	COG0745	RESPONSE REGULATOR receiver
H9Q12_RS10720	COG0733	neurotransmitter:sodium symporter activity
H9Q12_RS10725	COG2272	Belongs to the type-B carboxylesterase lipase family
H9Q12_RS10730	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H9Q12_RS10735	COG0626	cystathionine gamma-synthase activity
H9Q12_RS10760	COG1192	Involved in chromosome partitioning
H9Q12_RS10780	COG2226	methyltransferase
H9Q12_RS10790	COG0456	acetyltransferase
H9Q12_RS10800	COG2378	regulation of single-species biofilm formation
H9Q12_RS10805	COG1192	Involved in chromosome partitioning
H9Q12_RS10885	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H9Q12_RS10925	COG1131	(ABC) transporter
H9Q12_RS10935	COG0535	radical SAM domain protein
H9Q12_RS10945	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9Q12_RS10960	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H9Q12_RS10975	COG0583	DNA-binding transcription factor activity
H9Q12_RS10980	COG0067	glutamate synthase
H9Q12_RS10980	COG0069	glutamate synthase activity
H9Q12_RS10980	COG0070	glutamate synthase
H9Q12_RS10985	COG0493	'glutamate synthase
H9Q12_RS10995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9Q12_RS10995	COG1263	PTS System
H9Q12_RS11000	COG0366	Alpha amylase catalytic
H9Q12_RS11005	COG2188	Transcriptional regulator
H9Q12_RS11015	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H9Q12_RS11020	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H9Q12_RS11025	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H9Q12_RS11030	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H9Q12_RS11055	COG1982	Orn Lys Arg decarboxylase major
H9Q12_RS11060	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H9Q12_RS11065	COG3870	Protein conserved in bacteria
H9Q12_RS11070	COG0470	DNA polymerase III
H9Q12_RS11075	COG1774	PSP1 C-terminal conserved region
H9Q12_RS11080	COG4467	Involved in initiation control of chromosome replication
H9Q12_RS11085	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H9Q12_RS11090	COG2827	Endonuclease containing a URI domain
H9Q12_RS11095	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H9Q12_RS11105	COG0084	hydrolase, TatD family'
H9Q12_RS11110	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
H9Q12_RS11120	COG4466	Protein conserved in bacteria
H9Q12_RS11125	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H9Q12_RS11130	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H9Q12_RS11135	COG0251	oxidation-reduction process
H9Q12_RS11140	COG2088	sporulation resulting in formation of a cellular spore
H9Q12_RS11145	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H9Q12_RS11150	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H9Q12_RS11160	COG0193	aminoacyl-tRNA hydrolase activity
H9Q12_RS11165	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H9Q12_RS11170	COG2244	polysaccharide biosynthetic process
H9Q12_RS11175	COG3956	TIGRFAM MazG family protein
H9Q12_RS11180	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H9Q12_RS11190	COG1098	S1 RNA binding domain
H9Q12_RS11205	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H9Q12_RS11210	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H9Q12_RS11220	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H9Q12_RS11230	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H9Q12_RS11235	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H9Q12_RS11330	COG1289	transmembrane transporter activity
H9Q12_RS11335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H9Q12_RS11340	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
H9Q12_RS11345	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
H9Q12_RS11355	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H9Q12_RS11365	COG3880	PFAM UvrB UvrC protein
H9Q12_RS11370	COG3869	Catalyzes the specific phosphorylation of arginine residues in
H9Q12_RS11375	COG0542	response to heat
H9Q12_RS11410	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H9Q12_RS11415	COG4956	integral membrane protein (PIN domain superfamily)
H9Q12_RS11420	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H9Q12_RS11430	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H9Q12_RS11435	COG1045	serine acetyltransferase
H9Q12_RS11440	COG0215	cysteine-tRNA ligase activity
H9Q12_RS11445	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
H9Q12_RS11465	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H9Q12_RS11470	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H9Q12_RS11475	COG0250	Participates in transcription elongation, termination and antitermination
H9Q12_RS11480	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H9Q12_RS11485	COG0081	regulation of translation
H9Q12_RS11490	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H9Q12_RS11500	COG2813	Specifically methylates the guanine in position
H9Q12_RS11505	COG0085	RNA polymerase activity
H9Q12_RS11510	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H9Q12_RS11520	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H9Q12_RS11525	COG0049	tRNA binding
H9Q12_RS11530	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H9Q12_RS11535	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H9Q12_RS11540	COG3527	Alpha-acetolactate decarboxylase
H9Q12_RS11545	COG1473	amidohydrolase
H9Q12_RS11555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H9Q12_RS11585	COG0546	phosphoglycolate phosphatase activity
H9Q12_RS11590	COG1428	Deoxynucleoside kinase
H9Q12_RS11595	COG1428	Deoxynucleoside kinase
H9Q12_RS11605	COG0561	phosphatase activity
H9Q12_RS11630	COG1469	GTP cyclohydrolase I activity
H9Q12_RS11635	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
H9Q12_RS11650	COG1263	PTS System
H9Q12_RS11650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
H9Q12_RS11650	COG2190	(PTS) system
H9Q12_RS11665	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
H9Q12_RS11675	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H9Q12_RS11695	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H9Q12_RS11720	COG0535	radical SAM domain protein
H9Q12_RS11725	COG1994	Peptidase M50
H9Q12_RS11730	COG1131	(ABC) transporter
H9Q12_RS11755	COG0588	phosphoglycerate mutase activity
H9Q12_RS11760	COG0318	PFAM AMP-dependent synthetase and ligase
H9Q12_RS11765	COG0183	Belongs to the thiolase family
H9Q12_RS11795	COG2363	Small membrane protein
H9Q12_RS11820	COG1566	PFAM secretion protein HlyD family protein
H9Q12_RS11835	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H9Q12_RS11840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H9Q12_RS11865	COG0095	Lipoate-protein ligase
H9Q12_RS11870	COG0280	phosphate acetyltransferase
H9Q12_RS11900	COG0471	metal ion transport
H9Q12_RS11970	COG3682	Transcriptional regulator
H9Q12_RS11990	COG3344	reverse transcriptase
H9Q12_RS12005	COG4844	belongs to the
H9Q12_RS12015	COG1078	dGTPase activity
H9Q12_RS12030	COG0018	arginyl-trna synthetase
H9Q12_RS12035	COG0805	protein transport
H9Q12_RS12040	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H9Q12_RS12045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H9Q12_RS12050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9Q12_RS12055	COG0546	phosphoglycolate phosphatase activity
H9Q12_RS12105	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H9Q12_RS12105	COG2111	Na H antiporter
H9Q12_RS12110	COG2111	Na H antiporter
H9Q12_RS12115	COG1006	Multisubunit Na H antiporter MnhC subunit
H9Q12_RS12125	COG1863	multisubunit Na H antiporter MnhE subunit
H9Q12_RS12130	COG2212	antiporter activity
H9Q12_RS12135	COG1320	monovalent cation:proton antiporter activity
H9Q12_RS12140	COG0803	Belongs to the bacterial solute-binding protein 9 family
H9Q12_RS12145	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H9Q12_RS12150	COG1121	(ABC) transporter
H9Q12_RS12160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9Q12_RS12165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9Q12_RS12170	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H9Q12_RS12180	COG2423	ornithine cyclodeaminase activity
H9Q12_RS12185	COG4264	IucA IucC family
H9Q12_RS12190	COG2814	Major facilitator Superfamily
H9Q12_RS12195	COG4264	IucA IucC family
H9Q12_RS12200	COG4264	IucA IucC family
H9Q12_RS12210	COG0019	diaminopimelate decarboxylase activity
H9Q12_RS12215	COG1475	DNA binding
H9Q12_RS12225	COG0110	maltose O-acetyltransferase activity
H9Q12_RS12230	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
H9Q12_RS12240	COG1682	transport, permease protein
H9Q12_RS12245	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H9Q12_RS12250	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H9Q12_RS12265	COG1686	Belongs to the peptidase S11 family
H9Q12_RS12270	COG1132	(ABC) transporter
H9Q12_RS12290	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H9Q12_RS12295	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
H9Q12_RS12300	COG1120	ATPase activity
H9Q12_RS12305	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9Q12_RS12310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H9Q12_RS12320	COG0477	Major facilitator Superfamily
H9Q12_RS12325	COG3949	Membrane
H9Q12_RS12335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H9Q12_RS12340	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H9Q12_RS12345	COG0745	RESPONSE REGULATOR receiver
H9Q12_RS12355	COG1136	(ABC) transporter
H9Q12_RS12360	COG0577	efflux transmembrane transporter activity
H9Q12_RS12365	COG1392	Phosphate transport regulator
H9Q12_RS12370	COG0306	phosphate transporter
H9Q12_RS12375	COG3942	CHAP domain
H9Q12_RS12375	COG1388	LysM domain
H9Q12_RS12385	COG0352	thiamine-phosphate diphosphorylase activity
H9Q12_RS12395	COG2022	thiamine diphosphate biosynthetic process
H9Q12_RS12400	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H9Q12_RS12405	COG0217	transcriptional regulatory protein
H9Q12_RS12420	COG0583	DNA-binding transcription factor activity
H9Q12_RS12425	COG2814	Major facilitator Superfamily
H9Q12_RS12430	COG2839	Protein conserved in bacteria
H9Q12_RS12460	COG1611	Belongs to the LOG family
H9Q12_RS12465	COG1671	Belongs to the UPF0178 family
H9Q12_RS12475	COG1968	undecaprenyl-diphosphatase activity
H9Q12_RS12480	COG4988	ABC transporter
H9Q12_RS12485	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H9Q12_RS12495	COG0523	cobalamin synthesis protein
H9Q12_RS12500	COG4989	oxidoreductase activity
H9Q12_RS12520	COG0039	L-malate dehydrogenase activity
H9Q12_RS12540	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H9Q12_RS12545	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H9Q12_RS12565	COG1349	DNA-binding transcription factor activity
H9Q12_RS12570	COG1105	Belongs to the carbohydrate kinase PfkB family
H9Q12_RS12575	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9Q12_RS12575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9Q12_RS12575	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
H9Q12_RS12580	COG1253	flavin adenine dinucleotide binding
H9Q12_RS12585	COG0463	Glycosyl transferase, family 2
H9Q12_RS12600	COG0602	queuosine metabolic process
H9Q12_RS12605	COG0720	synthase
H9Q12_RS12615	COG0512	Glutamine amidotransferase of anthranilate synthase
H9Q12_RS12635	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H9Q12_RS12645	COG1368	sulfuric ester hydrolase activity
H9Q12_RS12650	COG0463	Glycosyl transferase, family 2
H9Q12_RS12675	COG0488	(ABC) transporter
H9Q12_RS12680	COG0514	ATP-dependent DNA helicase (RecQ)
H9Q12_RS12685	COG1125	glycine betaine transport
H9Q12_RS12685	COG0517	IMP dehydrogenase activity