locus-tag	class	description
DMB76_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DMB76_RS00010	COG0592	DNA-directed DNA polymerase activity
DMB76_RS00015	COG2501	S4 domain
DMB76_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DMB76_RS00025	COG0187	DNA topoisomerase II activity
DMB76_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DMB76_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DMB76_RS00045	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DMB76_RS00065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DMB76_RS00075	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
DMB76_RS00080	COG0359	binds to the 23S rRNA
DMB76_RS00085	COG0305	Participates in initiation and elongation during chromosome replication
DMB76_RS00090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DMB76_RS00105	COG0745	RESPONSE REGULATOR receiver
DMB76_RS00110	COG5002	protein histidine kinase activity
DMB76_RS00115	COG4863	YycH protein
DMB76_RS00125	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DMB76_RS00130	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DMB76_RS00135	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DMB76_RS00190	COG0693	protein deglycase activity
DMB76_RS00195	COG1063	alcohol dehydrogenase
DMB76_RS00215	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DMB76_RS00220	COG0579	oxidoreductase
DMB76_RS00250	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DMB76_RS00255	COG2814	Major facilitator Superfamily
DMB76_RS00260	COG0813	purine-nucleoside phosphorylase activity
DMB76_RS00265	COG2188	Transcriptional regulator
DMB76_RS00295	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DMB76_RS00300	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DMB76_RS00310	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
DMB76_RS00345	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DMB76_RS00355	COG1021	2,3-dihydroxybenzoate-AMP ligase
DMB76_RS00410	COG1169	isochorismate synthase
DMB76_RS00430	COG5492	domain, Protein
DMB76_RS00455	COG2855	membrane
DMB76_RS00460	COG0583	DNA-binding transcription factor activity
DMB76_RS00480	COG1028	Short-chain dehydrogenase reductase Sdr
DMB76_RS00510	COG0601	transmembrane transport
DMB76_RS00535	COG0745	RESPONSE REGULATOR receiver
DMB76_RS00540	COG2205	protein histidine kinase activity
DMB76_RS00550	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DMB76_RS00620	COG1882	Formate acetyltransferase
DMB76_RS00625	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DMB76_RS00640	COG1114	Component of the transport system for branched-chain amino acids
DMB76_RS00660	COG1131	(ABC) transporter
DMB76_RS00710	COG1288	antiporter activity
DMB76_RS00715	COG0549	Belongs to the carbamate kinase family
DMB76_RS00720	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DMB76_RS00730	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
DMB76_RS00735	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DMB76_RS00745	COG2376	Dihydroxyacetone kinase
DMB76_RS00750	COG1461	Dihydroxyacetone kinase
DMB76_RS00755	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
DMB76_RS00810	COG2814	Major facilitator Superfamily
DMB76_RS00835	COG2962	Rard protein
DMB76_RS00845	COG0471	metal ion transport
DMB76_RS00865	COG2353	YceI-like domain
DMB76_RS00880	COG0579	oxidoreductase
DMB76_RS00925	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DMB76_RS00945	COG0131	Imidazoleglycerol-phosphate dehydratase
DMB76_RS00955	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DMB76_RS01000	COG1309	transcriptional regulator
DMB76_RS01020	COG2814	Major facilitator Superfamily
DMB76_RS01070	COG2814	Major facilitator Superfamily
DMB76_RS01110	COG3942	CHAP domain
DMB76_RS01110	COG1705	Flagellar rod assembly protein muramidase FlgJ
DMB76_RS01120	COG1482	cell wall glycoprotein biosynthetic process
DMB76_RS01125	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DMB76_RS01125	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DMB76_RS01125	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DMB76_RS01130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DMB76_RS01130	COG3711	transcriptional antiterminator
DMB76_RS01185	COG1438	arginine binding
DMB76_RS01190	COG2235	arginine
DMB76_RS01195	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DMB76_RS01205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DMB76_RS01245	COG1045	serine acetyltransferase
DMB76_RS01250	COG3961	Belongs to the TPP enzyme family
DMB76_RS01255	COG1846	Transcriptional regulator
DMB76_RS01310	COG0438	transferase activity, transferring glycosyl groups
DMB76_RS01340	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DMB76_RS01350	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DMB76_RS01355	COG1316	TRANSCRIPTIONal
DMB76_RS01360	COG1785	Belongs to the alkaline phosphatase family
DMB76_RS01370	COG0745	RESPONSE REGULATOR receiver
DMB76_RS01375	COG2205	protein histidine kinase activity
DMB76_RS01380	COG1136	(ABC) transporter
DMB76_RS01395	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DMB76_RS01420	COG1846	Transcriptional regulator
DMB76_RS01430	COG0386	Belongs to the glutathione peroxidase family
DMB76_RS01440	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DMB76_RS01455	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DMB76_RS01455	COG1648	precorrin-2 dehydrogenase activity
DMB76_RS01475	COG3942	CHAP domain
DMB76_RS01485	COG1328	CTP reductase activity
DMB76_RS01490	COG0602	queuosine metabolic process
DMB76_RS01495	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DMB76_RS01505	COG1510	regulation of RNA biosynthetic process
DMB76_RS01510	COG1012	belongs to the aldehyde dehydrogenase family
DMB76_RS01515	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DMB76_RS01545	COG0574	Belongs to the PEP-utilizing enzyme family
DMB76_RS01545	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DMB76_RS01550	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DMB76_RS01555	COG0579	oxidoreductase
DMB76_RS01565	COG3588	fructose-bisphosphate aldolase
DMB76_RS01615	COG0583	DNA-binding transcription factor activity
DMB76_RS01620	COG0039	L-malate dehydrogenase activity
DMB76_RS01625	COG0028	Belongs to the TPP enzyme family
DMB76_RS01630	COG3527	Alpha-acetolactate decarboxylase
DMB76_RS01640	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DMB76_RS01645	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DMB76_RS01650	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DMB76_RS01680	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DMB76_RS01690	COG0167	dihydroorotate dehydrogenase activity
DMB76_RS01695	COG3001	Fructosamine kinase
DMB76_RS01705	COG1113	amino acid transport
DMB76_RS01720	COG1388	LysM domain
DMB76_RS01760	COG2608	mercury ion transmembrane transporter activity
DMB76_RS01810	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DMB76_RS01815	COG3425	synthase
DMB76_RS01835	COG0583	DNA-binding transcription factor activity
DMB76_RS01840	COG1380	Effector of murein hydrolase LrgA
DMB76_RS01845	COG1346	cytolysis
DMB76_RS01850	COG0028	Belongs to the TPP enzyme family
DMB76_RS01855	COG2190	(PTS) system
DMB76_RS01855	COG1263	PTS System
DMB76_RS01855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DMB76_RS01860	COG1266	CAAX protease self-immunity
DMB76_RS01865	COG1063	alcohol dehydrogenase
DMB76_RS01870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DMB76_RS01890	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DMB76_RS01900	COG2843	Capsule synthesis protein
DMB76_RS01915	COG4975	Glucose uptake
DMB76_RS01920	COG1869	D-ribose catabolic process
DMB76_RS01950	COG1760	l-serine dehydratase
DMB76_RS01955	COG1760	l-serine dehydratase
DMB76_RS01970	COG3764	Sortase (surface protein transpeptidase)
DMB76_RS01985	COG0778	Nitroreductase
DMB76_RS01990	COG1012	belongs to the aldehyde dehydrogenase family
DMB76_RS02005	COG1012	belongs to the aldehyde dehydrogenase family
DMB76_RS02010	COG3949	Membrane
DMB76_RS02020	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
DMB76_RS02025	COG0586	Pfam SNARE associated Golgi protein
DMB76_RS02070	COG4876	unkown
DMB76_RS02075	COG2357	RelA SpoT domain protein
DMB76_RS02080	COG0671	phosphoesterase, PA-phosphatase related
DMB76_RS02095	COG1802	Transcriptional regulator
DMB76_RS02105	COG2610	gluconate transmembrane transporter activity
DMB76_RS02120	COG0494	nUDIX hydrolase
DMB76_RS02140	COG4221	oxidoreductase activity
DMB76_RS02145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DMB76_RS02150	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DMB76_RS02160	COG1028	Short-chain dehydrogenase reductase Sdr
DMB76_RS02170	COG4808	Protein conserved in bacteria
DMB76_RS02185	COG4619	ABC transporter
DMB76_RS02190	COG0390	transport system, permease component
DMB76_RS02205	COG0531	amino acid
DMB76_RS02210	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
DMB76_RS02225	COG1174	glycine betaine transport
DMB76_RS02235	COG1174	glycine betaine transport
DMB76_RS02240	COG1346	cytolysis
DMB76_RS02275	COG0706	membrane insertase activity
DMB76_RS02285	COG0531	amino acid
DMB76_RS02310	COG2814	Major facilitator Superfamily
DMB76_RS02335	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DMB76_RS02340	COG0588	phosphoglycerate mutase activity
DMB76_RS02355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DMB76_RS02360	COG0765	amino acid transport
DMB76_RS02365	COG1126	abc transporter atp-binding protein
DMB76_RS02375	COG2348	transferase activity, transferring amino-acyl groups
DMB76_RS02405	COG0747	negative chemotaxis
DMB76_RS02420	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DMB76_RS02425	COG2146	nitrite reductase [NAD(P)H] activity
DMB76_RS02435	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DMB76_RS02440	COG1140	nitrate reductase beta subunit
DMB76_RS02450	COG2181	nitrate reductase activity
DMB76_RS02460	COG4585	Histidine kinase
DMB76_RS02465	COG2197	response regulator
DMB76_RS02470	COG2223	nitrite transmembrane transporter activity
DMB76_RS02480	COG1846	Transcriptional regulator
DMB76_RS02485	COG0778	Nitroreductase
DMB76_RS02560	COG0604	alcohol dehydrogenase
DMB76_RS02565	COG0456	acetyltransferase
DMB76_RS02570	COG0463	Glycosyl transferase, family 2
DMB76_RS02570	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DMB76_RS02580	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DMB76_RS02585	COG1620	l-lactate permease
DMB76_RS02600	COG3850	Histidine kinase
DMB76_RS02600	COG5002	protein histidine kinase activity
DMB76_RS02605	COG0745	RESPONSE REGULATOR receiver
DMB76_RS02610	COG0577	efflux transmembrane transporter activity
DMB76_RS02615	COG1136	(ABC) transporter
DMB76_RS02630	COG4640	response to antibiotic
DMB76_RS02635	COG2814	Major facilitator Superfamily
DMB76_RS02655	COG1566	PFAM secretion protein HlyD family protein
DMB76_RS02660	COG2814	Major facilitator Superfamily
DMB76_RS02685	COG0598	Magnesium transport protein CorA
DMB76_RS02690	COG1304	FMN binding
DMB76_RS02720	COG2094	Belongs to the DNA glycosylase MPG family
DMB76_RS02725	COG3152	Membrane
DMB76_RS02745	COG2017	converts alpha-aldose to the beta-anomer
DMB76_RS02750	COG2258	MOSC domain
DMB76_RS02755	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DMB76_RS02760	COG1266	CAAX protease self-immunity
DMB76_RS02765	COG0010	Belongs to the arginase family
DMB76_RS02790	COG1028	Short-chain dehydrogenase reductase Sdr
DMB76_RS02845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DMB76_RS02845	COG1263	PTS System
DMB76_RS02850	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DMB76_RS02870	COG2378	regulation of single-species biofilm formation
DMB76_RS02900	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DMB76_RS02910	COG2076	Multidrug Resistance protein
DMB76_RS02915	COG3942	CHAP domain
DMB76_RS02930	COG1757	Na H antiporter
DMB76_RS02935	COG3942	CHAP domain
DMB76_RS02960	COG0829	nickel cation binding
DMB76_RS02965	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DMB76_RS02970	COG0830	nickel cation binding
DMB76_RS02975	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
DMB76_RS02980	COG0804	urea catabolic process
DMB76_RS02985	COG0832	Belongs to the urease beta subunit family
DMB76_RS02990	COG0831	urea catabolic process
DMB76_RS02995	COG4413	Urea transporter
DMB76_RS03010	COG1268	BioY protein
DMB76_RS03020	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DMB76_RS03025	COG0725	ABC transporter, periplasmic molybdate-binding protein
DMB76_RS03030	COG4149	molybdate abc transporter
DMB76_RS03035	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DMB76_RS03040	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DMB76_RS03045	COG0521	Mo-molybdopterin cofactor biosynthetic process
DMB76_RS03050	COG0315	cyclic pyranopterin monophosphate synthase activity
DMB76_RS03055	COG0303	'Molybdopterin
DMB76_RS03060	COG1763	Mo-molybdopterin cofactor biosynthetic process
DMB76_RS03065	COG0314	molybdopterin synthase activity
DMB76_RS03075	COG0746	molybdenum cofactor guanylyltransferase activity
DMB76_RS03080	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DMB76_RS03105	COG2348	transferase activity, transferring amino-acyl groups
DMB76_RS03110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DMB76_RS03145	COG0551	DNA topoisomerase type I activity
DMB76_RS03145	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DMB76_RS03150	COG2252	PERMEase
DMB76_RS03165	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DMB76_RS03170	COG0088	Forms part of the polypeptide exit tunnel
DMB76_RS03175	COG0089	rRNA binding
DMB76_RS03180	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DMB76_RS03185	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DMB76_RS03190	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DMB76_RS03195	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DMB76_RS03200	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DMB76_RS03210	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DMB76_RS03215	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DMB76_RS03220	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DMB76_RS03225	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DMB76_RS03230	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DMB76_RS03235	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DMB76_RS03240	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DMB76_RS03245	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DMB76_RS03250	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DMB76_RS03255	COG1841	ribosomal large subunit assembly
DMB76_RS03260	COG0200	Binds to the 23S rRNA
DMB76_RS03265	COG0201	protein transport
DMB76_RS03270	COG0563	adenylate kinase activity
DMB76_RS03275	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DMB76_RS03280	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DMB76_RS03285	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DMB76_RS03295	COG0202	RNA polymerase activity
DMB76_RS03300	COG0203	ribosomal protein L17
DMB76_RS03305	COG1122	ATPase activity
DMB76_RS03310	COG1122	ATPase activity
DMB76_RS03320	COG0101	tRNA pseudouridine synthase activity
DMB76_RS03325	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DMB76_RS03330	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DMB76_RS03335	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DMB76_RS03345	COG0698	ribose 5-phosphate isomerase
DMB76_RS03350	COG0698	ribose 5-phosphate isomerase
DMB76_RS03385	COG2130	NADP-dependent
DMB76_RS03405	COG1302	Protein conserved in bacteria
DMB76_RS03410	COG4264	IucA IucC family
DMB76_RS03415	COG2814	Major facilitator Superfamily
DMB76_RS03420	COG4264	IucA IucC family
DMB76_RS03425	COG3457	Alanine racemase
DMB76_RS03430	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DMB76_RS03435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DMB76_RS03440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DMB76_RS03450	COG2329	Antibiotic biosynthesis monooxygenase
DMB76_RS03460	COG1988	membrane-bound metal-dependent
DMB76_RS03465	COG4284	Utp--glucose-1-phosphate uridylyltransferase
DMB76_RS03485	COG2814	Major facilitator Superfamily
DMB76_RS03490	COG0489	protein tyrosine kinase activity
DMB76_RS03540	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DMB76_RS03550	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DMB76_RS03555	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DMB76_RS03560	COG0561	phosphatase activity
DMB76_RS03580	COG0640	Transcriptional regulator
DMB76_RS03585	COG0702	epimerase
DMB76_RS03590	COG1482	cell wall glycoprotein biosynthetic process
DMB76_RS03615	COG0813	purine-nucleoside phosphorylase activity
DMB76_RS03620	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DMB76_RS03625	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DMB76_RS03630	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DMB76_RS03640	COG1854	S-ribosylhomocysteine lyase activity
DMB76_RS03660	COG5146	pantothenate kinase activity
DMB76_RS03670	COG3343	RNA polymerase activity
DMB76_RS03675	COG0504	CTP synthase activity
DMB76_RS03685	COG0191	fructose-bisphosphate aldolase activity
DMB76_RS03690	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DMB76_RS03700	COG1012	belongs to the aldehyde dehydrogenase family
DMB76_RS03705	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DMB76_RS03710	COG0254	rRNA binding
DMB76_RS03715	COG1435	thymidine kinase activity
DMB76_RS03725	COG2890	protein-(glutamine-N5) methyltransferase activity
DMB76_RS03730	COG0009	L-threonylcarbamoyladenylate synthase
DMB76_RS03735	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DMB76_RS03745	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DMB76_RS03750	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DMB76_RS03755	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DMB76_RS03765	COG0356	it plays a direct role in the translocation of protons across the membrane
DMB76_RS03775	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DMB76_RS03780	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DMB76_RS03785	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DMB76_RS03790	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DMB76_RS03795	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DMB76_RS03800	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DMB76_RS03810	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DMB76_RS03815	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DMB76_RS03825	COG0629	single-stranded DNA binding
DMB76_RS03830	COG1388	LysM domain
DMB76_RS03835	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DMB76_RS03845	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DMB76_RS03850	COG0352	thiamine-phosphate diphosphorylase activity
DMB76_RS03855	COG0706	membrane insertase activity
DMB76_RS03865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DMB76_RS03870	COG1937	Protein conserved in bacteria
DMB76_RS03880	COG0772	Belongs to the SEDS family
DMB76_RS03890	COG1181	Belongs to the D-alanine--D-alanine ligase family
DMB76_RS03895	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DMB76_RS03900	COG0513	Belongs to the DEAD box helicase family
DMB76_RS03920	COG0736	holo-[acyl-carrier-protein] synthase activity
DMB76_RS03925	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DMB76_RS03935	COG2337	Toxic component of a toxin-antitoxin (TA) module
DMB76_RS03940	COG2208	phosphoserine phosphatase activity
DMB76_RS03955	COG1191	sigma factor activity
DMB76_RS03960	COG2183	response to ionizing radiation
DMB76_RS03965	COG3091	SprT-like family
DMB76_RS04000	COG0066	3-isopropylmalate dehydratase activity
DMB76_RS04040	COG0802	atpase or kinase
DMB76_RS04045	COG1214	PFAM Peptidase M22, glycoprotease
DMB76_RS04050	COG0456	acetyltransferase
DMB76_RS04055	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DMB76_RS04060	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DMB76_RS04065	COG0488	(ABC) transporter
DMB76_RS04070	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DMB76_RS04100	COG1621	beta-fructofuranosidase activity
DMB76_RS04105	COG3279	Response regulator of the LytR AlgR family
DMB76_RS04110	COG3290	protein histidine kinase activity
DMB76_RS04145	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DMB76_RS04150	COG0459	protein refolding
DMB76_RS04205	COG1725	Transcriptional regulator
DMB76_RS04220	COG1131	(ABC) transporter
DMB76_RS04265	COG2706	6-phosphogluconolactonase activity
DMB76_RS04275	COG1227	inorganic diphosphatase activity
DMB76_RS04280	COG1335	isochorismatase
DMB76_RS04290	COG0077	Prephenate dehydratase
DMB76_RS04300	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DMB76_RS04305	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DMB76_RS04310	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
DMB76_RS04320	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DMB76_RS04325	COG4496	protein, YerC YecD
DMB76_RS04330	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
DMB76_RS04335	COG0210	DNA helicase
DMB76_RS04340	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DMB76_RS04355	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DMB76_RS04360	COG0154	amidase activity
DMB76_RS04365	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DMB76_RS04370	COG1597	lipid kinase activity
DMB76_RS04375	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DMB76_RS04385	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DMB76_RS04415	COG4129	membrane
DMB76_RS04420	COG0024	Methionine aminopeptidase
DMB76_RS04445	COG1295	ribonuclease BN
DMB76_RS04455	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DMB76_RS04460	COG4840	Belongs to the UPF0435 family
DMB76_RS04465	COG2309	aminopeptidase activity
DMB76_RS04470	COG1607	acyl-coa hydrolase
DMB76_RS04475	COG0535	radical SAM domain protein
DMB76_RS04485	COG0693	protein deglycase activity
DMB76_RS04490	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DMB76_RS04495	COG2137	regulation of response to DNA damage stimulus
DMB76_RS04505	COG1134	teichoic acid transport
DMB76_RS04505	COG1388	LysM domain
DMB76_RS04515	COG1988	membrane-bound metal-dependent
DMB76_RS04525	COG3557	Belongs to the UPF0374 family
DMB76_RS04535	COG4129	membrane
DMB76_RS04540	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DMB76_RS04545	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DMB76_RS04550	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DMB76_RS04555	COG0735	belongs to the Fur family
DMB76_RS04745	COG0363	glucosamine-6-phosphate deaminase activity
DMB76_RS04760	COG0114	fumarate hydratase activity
DMB76_RS04765	COG0564	pseudouridine synthase activity
DMB76_RS04775	COG2197	response regulator
DMB76_RS04790	COG3679	Belongs to the UPF0342 family
DMB76_RS04795	COG0420	3'-5' exonuclease activity
DMB76_RS04805	COG3481	metal-dependent phosphohydrolase, HD sub domain
DMB76_RS04815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DMB76_RS04830	COG0537	adenosine 5'-monophosphoramidase activity
DMB76_RS04835	COG1131	(ABC) transporter
DMB76_RS04840	COG4473	ABC transporter
DMB76_RS04850	COG2329	Antibiotic biosynthesis monooxygenase
DMB76_RS04855	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DMB76_RS04860	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DMB76_RS04865	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DMB76_RS04905	COG0318	PFAM AMP-dependent synthetase and ligase
DMB76_RS04915	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DMB76_RS04925	COG1506	peptidase
DMB76_RS04935	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DMB76_RS04950	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DMB76_RS04955	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DMB76_RS04965	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DMB76_RS04985	COG4193	domain, Protein
DMB76_RS04985	COG5632	N-Acetylmuramoyl-L-alanine amidase
DMB76_RS04985	COG3266	domain, Protein
DMB76_RS04995	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DMB76_RS04995	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DMB76_RS05005	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DMB76_RS05005	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DMB76_RS05010	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DMB76_RS05015	COG0506	proline dehydrogenase activity
DMB76_RS05020	COG2267	carboxylic ester hydrolase activity
DMB76_RS05030	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DMB76_RS05035	COG1242	4 iron, 4 sulfur cluster binding
DMB76_RS05040	COG2814	Major facilitator Superfamily
DMB76_RS05045	COG0495	leucyl-tRNA aminoacylation
DMB76_RS05100	COG2081	HI0933 family
DMB76_RS05105	COG2244	polysaccharide biosynthetic process
DMB76_RS05120	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DMB76_RS05125	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DMB76_RS05130	COG0510	thiamine kinase activity
DMB76_RS05135	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DMB76_RS05150	COG1363	Peptidase, m42
DMB76_RS05155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DMB76_RS05160	COG4848	Belongs to the UPF0354 family
DMB76_RS05165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DMB76_RS05170	COG1674	ftsk spoiiie
DMB76_RS05175	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DMB76_RS05180	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
DMB76_RS05190	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DMB76_RS05190	COG1605	Chorismate mutase
DMB76_RS05195	COG1609	Transcriptional regulator
DMB76_RS05205	COG0454	-acetyltransferase
DMB76_RS05215	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DMB76_RS05220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DMB76_RS05225	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DMB76_RS05230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMB76_RS05235	COG0204	Acyl-transferase
DMB76_RS05240	COG1263	PTS System
DMB76_RS05240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DMB76_RS05265	COG0584	glycerophosphoryl diester phosphodiesterase
DMB76_RS05270	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DMB76_RS05275	COG1956	GAF domain-containing protein
DMB76_RS05280	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
DMB76_RS05285	COG1104	cysteine desulfurase activity
DMB76_RS05290	COG0301	tRNA thio-modification
DMB76_RS05305	COG0827	DNA restriction-modification system
DMB76_RS05310	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DMB76_RS05315	COG0589	response to stress
DMB76_RS05320	COG0686	Belongs to the AlaDH PNT family
DMB76_RS05325	COG0006	proline dipeptidase activity
DMB76_RS05330	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DMB76_RS05340	COG4109	DRTGG domain
DMB76_RS05345	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DMB76_RS05350	COG0587	DNA-directed DNA polymerase activity
DMB76_RS05355	COG0281	malic enzyme
DMB76_RS05360	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DMB76_RS05370	COG0205	6-phosphofructokinase activity
DMB76_RS05375	COG0469	pyruvate kinase activity
DMB76_RS05380	COG1113	amino acid transport
DMB76_RS05385	COG0372	Belongs to the citrate synthase family
DMB76_RS05390	COG0538	isocitrate dehydrogenase activity
DMB76_RS05395	COG0745	RESPONSE REGULATOR receiver
DMB76_RS05400	COG5002	protein histidine kinase activity
DMB76_RS05405	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DMB76_RS05405	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DMB76_RS05415	COG0237	dephospho-CoA kinase activity
DMB76_RS05420	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DMB76_RS05425	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DMB76_RS05430	COG3611	Membrane attachment protein
DMB76_RS05435	COG1484	DNA-dependent DNA replication
DMB76_RS05440	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DMB76_RS05445	COG0833	amino acid
DMB76_RS05450	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DMB76_RS05455	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DMB76_RS05460	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DMB76_RS05465	COG4112	unkown
DMB76_RS05475	COG0544	peptidyl-prolyl cis-trans isomerase activity
DMB76_RS05480	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DMB76_RS05485	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DMB76_RS05490	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DMB76_RS05500	COG0181	hydroxymethylbilane synthase activity
DMB76_RS05505	COG0113	porphobilinogen synthase activity
DMB76_RS05510	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DMB76_RS05520	COG2818	Glycosylase
DMB76_RS05525	COG0525	valine-tRNA ligase activity
DMB76_RS05530	COG0285	dihydrofolate synthase activity
DMB76_RS05565	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DMB76_RS05570	COG2868	ribosomal protein
DMB76_RS05575	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DMB76_RS05580	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DMB76_RS05590	COG0632	four-way junction helicase activity
DMB76_RS05595	COG2255	four-way junction helicase activity
DMB76_RS05600	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DMB76_RS05605	COG0343	queuine tRNA-ribosyltransferase activity
DMB76_RS05610	COG1862	Preprotein translocase
DMB76_RS05615	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DMB76_RS05615	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DMB76_RS05620	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DMB76_RS05620	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DMB76_RS05630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DMB76_RS05635	COG1490	D-aminoacyl-tRNA deacylase activity
DMB76_RS05640	COG0860	N-Acetylmuramoyl-L-alanine amidase
DMB76_RS05645	COG0124	histidyl-tRNA synthetase
DMB76_RS05650	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DMB76_RS05660	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DMB76_RS05665	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DMB76_RS05670	COG1959	2 iron, 2 sulfur cluster binding
DMB76_RS05680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DMB76_RS05685	COG1104	cysteine desulfurase activity
DMB76_RS05690	COG0482	sulfurtransferase activity
DMB76_RS05700	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DMB76_RS05705	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DMB76_RS05710	COG4472	Bacterial protein of unknown function (DUF965)
DMB76_RS05715	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DMB76_RS05720	COG3906	Belongs to the UPF0473 family
DMB76_RS05730	COG0826	peptidase U32
DMB76_RS05735	COG0826	peptidase U32
DMB76_RS05740	COG0572	uridine kinase
DMB76_RS05745	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DMB76_RS05750	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DMB76_RS05755	COG1984	allophanate hydrolase subunit 2
DMB76_RS05760	COG0511	ligase activity, forming carbon-carbon bonds
DMB76_RS05765	COG0439	Biotin carboxylase
DMB76_RS05770	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DMB76_RS05780	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DMB76_RS05785	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DMB76_RS05790	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DMB76_RS05795	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DMB76_RS05800	COG1534	Rna-binding protein
DMB76_RS05805	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DMB76_RS05810	COG1713	HD superfamily hydrolase involved in NAD metabolism
DMB76_RS05815	COG0799	negative regulation of ribosome biogenesis
DMB76_RS05825	COG1555	photosystem II stabilization
DMB76_RS05825	COG1596	polysaccharide export
DMB76_RS05830	COG2131	deaminase
DMB76_RS05840	COG1466	dna polymerase III delta subunit
DMB76_RS05845	COG0268	Binds directly to 16S ribosomal RNA
DMB76_RS05850	COG0481	GTPase activity
DMB76_RS05855	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DMB76_RS05860	COG1420	regulation of RNA biosynthetic process
DMB76_RS05865	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DMB76_RS05870	COG0443	Heat shock 70 kDa protein
DMB76_RS05875	COG0484	heat shock protein binding
DMB76_RS05880	COG2264	protein methyltransferase activity
DMB76_RS05885	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DMB76_RS05890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DMB76_RS05900	COG1030	water channel activity
DMB76_RS05905	COG4864	UPF0365 protein
DMB76_RS05915	COG1702	phosphate starvation-inducible protein PhoH
DMB76_RS05920	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DMB76_RS05935	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DMB76_RS05940	COG1381	Involved in DNA repair and RecF pathway recombination
DMB76_RS05945	COG0423	glycine-tRNA ligase activity
DMB76_RS05950	COG0517	IMP dehydrogenase activity
DMB76_RS05955	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DMB76_RS05960	COG0358	DNA primase activity
DMB76_RS05965	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DMB76_RS05970	COG2384	SAM-dependent methyltransferase
DMB76_RS05975	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DMB76_RS05980	COG0513	Belongs to the DEAD box helicase family
DMB76_RS05985	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DMB76_RS05990	COG1121	(ABC) transporter
DMB76_RS05995	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DMB76_RS06005	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DMB76_RS06010	COG0768	penicillin binding
DMB76_RS06015	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DMB76_RS06020	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DMB76_RS06030	COG4483	Protein conserved in bacteria
DMB76_RS06035	COG1940	carbohydrate kinase activity
DMB76_RS06040	COG0011	TIGRFAM Protein of
DMB76_RS06045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DMB76_RS06055	COG1459	type II secretion system
DMB76_RS06070	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DMB76_RS06075	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DMB76_RS06080	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DMB76_RS06085	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DMB76_RS06090	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DMB76_RS06095	COG0095	Lipoate-protein ligase
DMB76_RS06110	COG0006	proline dipeptidase activity
DMB76_RS06115	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DMB76_RS06125	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DMB76_RS06140	COG0511	ligase activity, forming carbon-carbon bonds
DMB76_RS06145	COG0439	Biotin carboxylase
DMB76_RS06150	COG1302	Protein conserved in bacteria
DMB76_RS06155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DMB76_RS06160	COG1570	exodeoxyribonuclease VII activity
DMB76_RS06175	COG1438	arginine binding
DMB76_RS06180	COG0497	DNA recombination
DMB76_RS06185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DMB76_RS06190	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DMB76_RS06195	COG0022	dehydrogenase e1 component
DMB76_RS06200	COG0508	dehydrogenase complex catalyzes the overall conversion of
DMB76_RS06210	COG4129	membrane
DMB76_RS06220	COG2195	Cleaves the N-terminal amino acid of tripeptides
DMB76_RS06225	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DMB76_RS06240	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DMB76_RS06245	COG1234	tRNA 3'-trailer cleavage
DMB76_RS06265	COG0494	nUDIX hydrolase
DMB76_RS06270	COG0735	belongs to the Fur family
DMB76_RS06275	COG4974	Belongs to the 'phage' integrase family
DMB76_RS06285	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DMB76_RS06290	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DMB76_RS06295	COG1187	pseudouridine synthase activity
DMB76_RS06300	COG0745	RESPONSE REGULATOR receiver
DMB76_RS06315	COG1141	Ferredoxin
DMB76_RS06325	COG0514	ATP-dependent DNA helicase (RecQ)
DMB76_RS06330	COG1388	LysM domain
DMB76_RS06335	COG0492	ferredoxin-NADP+ reductase activity
DMB76_RS06345	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DMB76_RS06350	COG0539	negative regulation of cytoplasmic translation
DMB76_RS06355	COG1160	GTP binding
DMB76_RS06360	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DMB76_RS06375	COG2226	methyltransferase
DMB76_RS06385	COG0105	UTP biosynthetic process
DMB76_RS06390	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DMB76_RS06395	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DMB76_RS06400	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DMB76_RS06410	COG5582	Belongs to the UPF0302 family
DMB76_RS06420	COG2738	Putative neutral zinc metallopeptidase
DMB76_RS06425	COG1694	Mazg nucleotide pyrophosphohydrolase
DMB76_RS06430	COG0438	transferase activity, transferring glycosyl groups
DMB76_RS06435	COG0617	tRNA 3'-terminal CCA addition
DMB76_RS06440	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DMB76_RS06440	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DMB76_RS06445	COG1199	ATP-dependent helicase activity
DMB76_RS06445	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DMB76_RS06450	COG0017	Asparaginyl-tRNA synthetase
DMB76_RS06455	COG3935	DnaD domain protein
DMB76_RS06460	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DMB76_RS06470	COG4499	WXG100 protein secretion system (Wss), protein YukC
DMB76_RS06470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DMB76_RS06475	COG3331	DNA recombination
DMB76_RS06485	COG4474	Belongs to the UPF0398 family
DMB76_RS06490	COG3599	regulation of cell shape
DMB76_RS06500	COG0116	Belongs to the methyltransferase superfamily
DMB76_RS06510	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DMB76_RS06515	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DMB76_RS06545	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DMB76_RS06555	COG1413	lyase activity
DMB76_RS06560	COG1413	lyase activity
DMB76_RS06595	COG2190	(PTS) system
DMB76_RS06600	COG4479	Belongs to the UPF0346 family
DMB76_RS06605	COG0793	Belongs to the peptidase S41A family
DMB76_RS06615	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DMB76_RS06620	COG0671	phosphoesterase, PA-phosphatase related
DMB76_RS06635	COG4209	transmembrane transport
DMB76_RS06640	COG4209	transmembrane transport
DMB76_RS06660	COG0534	Mate efflux family protein
DMB76_RS06670	COG0745	RESPONSE REGULATOR receiver
DMB76_RS06675	COG5002	protein histidine kinase activity
DMB76_RS06715	COG1114	Component of the transport system for branched-chain amino acids
DMB76_RS06730	COG1254	Belongs to the acylphosphatase family
DMB76_RS06740	COG1278	Cold shock
DMB76_RS06775	COG1473	amidohydrolase
DMB76_RS06785	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DMB76_RS06790	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DMB76_RS06795	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DMB76_RS06800	COG0488	(ABC) transporter
DMB76_RS06805	COG2996	Protein conserved in bacteria
DMB76_RS06810	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DMB76_RS06815	COG0573	inorganic phosphate transmembrane transporter activity
DMB76_RS06820	COG0581	inorganic phosphate transmembrane transporter activity
DMB76_RS06825	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DMB76_RS06830	COG0704	Plays a role in the regulation of phosphate uptake
DMB76_RS06835	COG1164	Oligoendopeptidase f
DMB76_RS06875	COG2348	transferase activity, transferring amino-acyl groups
DMB76_RS06880	COG2348	transferase activity, transferring amino-acyl groups
DMB76_RS06915	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DMB76_RS06920	COG1942	4-Oxalocrotonate Tautomerase
DMB76_RS06935	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DMB76_RS06935	COG0392	lysyltransferase activity
DMB76_RS06940	COG0628	permease
DMB76_RS06945	COG3711	transcriptional antiterminator
DMB76_RS06950	COG1115	amino acid carrier protein
DMB76_RS06955	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DMB76_RS06960	COG0187	DNA topoisomerase II activity
DMB76_RS06965	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DMB76_RS06980	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DMB76_RS06985	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DMB76_RS06990	COG1970	mechanosensitive ion channel activity
DMB76_RS06995	COG0419	ATPase involved in DNA repair
DMB76_RS07005	COG4846	Membrane protein involved in cytochrome C biogenesis
DMB76_RS07015	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DMB76_RS07020	COG4224	UPF0291 protein
DMB76_RS07030	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DMB76_RS07045	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DMB76_RS07060	COG0833	amino acid
DMB76_RS07075	COG0083	homoserine kinase activity
DMB76_RS07080	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DMB76_RS07085	COG0460	homoserine dehydrogenase
DMB76_RS07090	COG0527	aspartate kinase activity
DMB76_RS07180	COG0174	glutamine synthetase
DMB76_RS07185	COG0789	Transcriptional regulator
DMB76_RS07190	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DMB76_RS07200	COG0386	Belongs to the glutathione peroxidase family
DMB76_RS07205	COG1923	regulation of RNA biosynthetic process
DMB76_RS07210	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DMB76_RS07220	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DMB76_RS07225	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DMB76_RS07230	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DMB76_RS07235	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
DMB76_RS07240	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DMB76_RS07245	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DMB76_RS07255	COG4550	Control of competence regulator ComK, YlbF/YmcA
DMB76_RS07260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DMB76_RS07270	COG4195	phage-related replication protein
DMB76_RS07275	COG1013	pyruvate-flavodoxin oxidoreductase activity
DMB76_RS07280	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DMB76_RS07280	COG0674	pyruvate-flavodoxin oxidoreductase activity
DMB76_RS07285	COG1692	metallophosphoesterase
DMB76_RS07295	COG1418	mRNA catabolic process
DMB76_RS07300	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DMB76_RS07305	COG1058	Belongs to the CinA family
DMB76_RS07305	COG1546	Belongs to the CinA family
DMB76_RS07310	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DMB76_RS07325	COG0300	oxidoreductase activity
DMB76_RS07330	COG0612	Peptidase, M16
DMB76_RS07335	COG0612	Peptidase, M16
DMB76_RS07340	COG2188	Transcriptional regulator
DMB76_RS07345	COG1674	ftsk spoiiie
DMB76_RS07350	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DMB76_RS07355	COG1185	polyribonucleotide nucleotidyltransferase activity
DMB76_RS07360	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DMB76_RS07365	COG0196	riboflavin kinase activity
DMB76_RS07370	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DMB76_RS07375	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DMB76_RS07380	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DMB76_RS07390	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DMB76_RS07395	COG0195	Participates in both transcription termination and antitermination
DMB76_RS07400	COG0779	Required for maturation of 30S ribosomal subunits
DMB76_RS07405	COG2176	DNA-directed DNA polymerase activity
DMB76_RS07410	COG0442	prolyl-tRNA aminoacylation
DMB76_RS07420	COG4589	Belongs to the CDS family
DMB76_RS07425	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DMB76_RS07430	COG0233	cytoplasmic translational termination
DMB76_RS07435	COG0528	UMP kinase activity
DMB76_RS07440	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DMB76_RS07445	COG0052	Belongs to the universal ribosomal protein uS2 family
DMB76_RS07450	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DMB76_RS07460	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DMB76_RS07465	COG4974	Belongs to the 'phage' integrase family
DMB76_RS07470	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DMB76_RS07475	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DMB76_RS07485	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DMB76_RS07490	COG0045	succinate-CoA ligase (ADP-forming) activity
DMB76_RS07495	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DMB76_RS07515	COG0335	large ribosomal subunit rRNA binding
DMB76_RS07520	COG0336	Belongs to the RNA methyltransferase TrmD family
DMB76_RS07525	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DMB76_RS07530	COG0228	four-way junction DNA binding
DMB76_RS07535	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DMB76_RS07540	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DMB76_RS07545	COG0552	protein localization to endoplasmic reticulum
DMB76_RS07550	COG1196	nuclear chromosome segregation
DMB76_RS07555	COG0571	ribonuclease III activity
DMB76_RS07560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DMB76_RS07565	COG1028	Short-chain dehydrogenase reductase Sdr
DMB76_RS07575	COG0416	fatty acid biosynthetic process
DMB76_RS07580	COG1349	DNA-binding transcription factor activity
DMB76_RS07585	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DMB76_RS07590	COG1525	nuclease
DMB76_RS07600	COG1461	Dihydroxyacetone kinase
DMB76_RS07605	COG1302	Protein conserved in bacteria
DMB76_RS07610	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DMB76_RS07615	COG1564	THIamine pyrophosphokinase
DMB76_RS07620	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DMB76_RS07625	COG1162	GTPase activity
DMB76_RS07635	COG0631	protein serine/threonine phosphatase activity
DMB76_RS07640	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DMB76_RS07645	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DMB76_RS07645	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DMB76_RS07650	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DMB76_RS07655	COG0242	peptide deformylase activity
DMB76_RS07665	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DMB76_RS07670	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DMB76_RS07675	COG1758	RNA polymerase activity
DMB76_RS07680	COG0194	GDP metabolic process
DMB76_RS07685	COG1293	RNA-binding protein homologous to eukaryotic snRNP
DMB76_RS07700	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DMB76_RS07705	COG0284	orotidine-5'-phosphate decarboxylase activity
DMB76_RS07710	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DMB76_RS07715	COG0505	Belongs to the CarA family
DMB76_RS07720	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DMB76_RS07725	COG0540	Belongs to the ATCase OTCase family
DMB76_RS07730	COG2233	PERMEase
DMB76_RS07735	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DMB76_RS07740	COG0564	pseudouridine synthase activity
DMB76_RS07745	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DMB76_RS07760	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DMB76_RS07765	COG3599	regulation of cell shape
DMB76_RS07775	COG0762	integral membrane protein
DMB76_RS07780	COG1799	cell septum assembly
DMB76_RS07785	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DMB76_RS07790	COG1496	oxidoreductase activity
DMB76_RS07795	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DMB76_RS07800	COG0849	cell division
DMB76_RS07805	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DMB76_RS07810	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DMB76_RS07815	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DMB76_RS07820	COG0768	penicillin binding
DMB76_RS07825	COG4839	cell division protein FtsL
DMB76_RS07830	COG0275	rRNA processing
DMB76_RS07840	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
DMB76_RS07845	COG0454	-acetyltransferase
DMB76_RS07880	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DMB76_RS07885	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DMB76_RS07890	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DMB76_RS07895	COG1053	succinate dehydrogenase
DMB76_RS07900	COG2009	succinate dehydrogenase
DMB76_RS07905	COG0322	excinuclease ABC activity
DMB76_RS07910	COG3118	belongs to the thioredoxin family
DMB76_RS07915	COG1193	negative regulation of DNA recombination
DMB76_RS07920	COG1796	DNA polymerase
DMB76_RS07920	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DMB76_RS07930	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DMB76_RS07935	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DMB76_RS07940	COG0072	phenylalanine-tRNA ligase activity
DMB76_RS07940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DMB76_RS07945	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DMB76_RS07950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DMB76_RS07965	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DMB76_RS07975	COG1323	Belongs to the UPF0348 family
DMB76_RS07980	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DMB76_RS07985	COG0742	ribosomal rna small subunit methyltransferase
DMB76_RS07995	COG4471	UPF0298 protein
DMB76_RS08015	COG3679	Belongs to the UPF0342 family
DMB76_RS08020	COG2340	Cysteine-rich secretory protein family
DMB76_RS08030	COG0109	protoheme IX farnesyltransferase activity
DMB76_RS08035	COG1612	heme a metabolic process
DMB76_RS08045	COG0772	Belongs to the SEDS family
DMB76_RS08050	COG4838	Belongs to the UPF0358 family
DMB76_RS08055	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DMB76_RS08060	COG4896	Protein conserved in bacteria
DMB76_RS08065	COG1217	gtp-binding protein TYPA
DMB76_RS08075	COG0483	inositol monophosphate 1-phosphatase activity
DMB76_RS08085	COG1914	H( )-stimulated, divalent metal cation uptake system
DMB76_RS08100	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DMB76_RS08105	COG1177	transmembrane transport
DMB76_RS08110	COG1176	ABC-type spermidine putrescine transport system, permease component I
DMB76_RS08125	COG4476	Belongs to the UPF0223 family
DMB76_RS08135	COG0508	dehydrogenase complex catalyzes the overall conversion of
DMB76_RS08140	COG0022	dehydrogenase e1 component
DMB76_RS08145	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DMB76_RS08155	COG0242	peptide deformylase activity
DMB76_RS08160	COG5503	Protein of unknown function (DUF1447)
DMB76_RS08165	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DMB76_RS08170	COG0569	domain protein
DMB76_RS08190	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DMB76_RS08195	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DMB76_RS08205	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DMB76_RS08230	COG4172	Belongs to the ABC transporter superfamily
DMB76_RS08235	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DMB76_RS08240	COG0151	Belongs to the GarS family
DMB76_RS08245	COG0138	bifunctional purine biosynthesis protein purh
DMB76_RS08250	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DMB76_RS08255	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DMB76_RS08260	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DMB76_RS08265	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DMB76_RS08270	COG0047	phosphoribosylformylglycinamidine synthase activity
DMB76_RS08275	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DMB76_RS08280	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DMB76_RS08285	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DMB76_RS08290	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DMB76_RS08310	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
DMB76_RS08310	COG3266	domain, Protein
DMB76_RS08310	COG4932	domain protein
DMB76_RS08315	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DMB76_RS08320	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DMB76_RS08325	COG1845	cytochrome c oxidase, subunit III
DMB76_RS08330	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DMB76_RS08345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DMB76_RS08350	COG1316	TRANSCRIPTIONal
DMB76_RS08365	COG4193	domain, Protein
DMB76_RS08365	COG3266	domain, Protein
DMB76_RS08365	COG5632	N-Acetylmuramoyl-L-alanine amidase
DMB76_RS08380	COG0436	Aminotransferase
DMB76_RS08385	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DMB76_RS08390	COG0596	Alpha beta hydrolase
DMB76_RS08395	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DMB76_RS08400	COG1169	isochorismate synthase
DMB76_RS08405	COG1575	Belongs to the MenA family. Type 1 subfamily
DMB76_RS08475	COG4873	Protein conserved in bacteria
DMB76_RS08490	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DMB76_RS08495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMB76_RS08500	COG0861	Integral membrane protein TerC family
DMB76_RS08505	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DMB76_RS08515	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DMB76_RS08520	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DMB76_RS08525	COG2814	Major facilitator Superfamily
DMB76_RS08530	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DMB76_RS08540	COG0628	permease
DMB76_RS08555	COG2239	Acts as a magnesium transporter
DMB76_RS08560	COG0564	pseudouridine synthase activity
DMB76_RS08565	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DMB76_RS08570	COG2357	RelA SpoT domain protein
DMB76_RS08590	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DMB76_RS08595	COG1164	Oligoendopeptidase f
DMB76_RS08605	COG4862	establishment of competence for transformation
DMB76_RS08610	COG1393	Belongs to the ArsC family
DMB76_RS08615	COG0180	Tryptophanyl-tRNA synthetase
DMB76_RS08650	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DMB76_RS08660	COG0542	response to heat
DMB76_RS08675	COG0561	phosphatase activity
DMB76_RS08690	COG0179	Fumarylacetoacetate (FAA) hydrolase
DMB76_RS08695	COG1074	ATP-dependent DNA helicase activity
DMB76_RS08700	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DMB76_RS08715	COG0398	Pfam SNARE associated Golgi protein
DMB76_RS08720	COG0166	Belongs to the GPI family
DMB76_RS08725	COG0137	argininosuccinate synthase activity
DMB76_RS08730	COG0165	Argininosuccinate lyase
DMB76_RS08735	COG0584	glycerophosphoryl diester phosphodiesterase
DMB76_RS08750	COG1902	pentaerythritol trinitrate reductase activity
DMB76_RS08755	COG1098	S1 RNA binding domain
DMB76_RS08760	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DMB76_RS08770	COG2111	Na H antiporter
DMB76_RS08770	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DMB76_RS08775	COG2111	Na H antiporter
DMB76_RS08780	COG1006	Multisubunit Na H antiporter MnhC subunit
DMB76_RS08785	COG0651	ATP synthesis coupled electron transport
DMB76_RS08790	COG1863	multisubunit Na H antiporter MnhE subunit
DMB76_RS08795	COG2212	antiporter activity
DMB76_RS08800	COG1320	monovalent cation:proton antiporter activity
DMB76_RS08810	COG2050	protein possibly involved in aromatic compounds catabolism
DMB76_RS08815	COG2056	Na+-H+ antiporter family
DMB76_RS08820	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DMB76_RS08825	COG1252	NADH dehydrogenase
DMB76_RS08830	COG0316	Belongs to the HesB IscA family
DMB76_RS08835	COG4844	belongs to the
DMB76_RS08845	COG4837	Protein of unknown function (DUF1462)
DMB76_RS08850	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DMB76_RS08855	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DMB76_RS08865	COG1696	Membrane protein involved in D-alanine export
DMB76_RS08870	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DMB76_RS08880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DMB76_RS08885	COG0647	UMP catabolic process
DMB76_RS08890	COG2445	Protein of unknown function DUF86
DMB76_RS08900	COG4470	Protein conserved in bacteria
DMB76_RS08905	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DMB76_RS08910	COG0737	Belongs to the 5'-nucleotidase family
DMB76_RS08915	COG0730	response to heat
DMB76_RS08920	COG1801	Protein of unknown function DUF72
DMB76_RS08950	COG0719	Fe-S assembly protein
DMB76_RS08955	COG0822	iron-sulfur transferase activity
DMB76_RS08960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DMB76_RS08965	COG0719	Fe-S assembly protein
DMB76_RS08970	COG0396	ATPase activity
DMB76_RS08980	COG3237	CsbD-like
DMB76_RS08985	COG1464	Belongs to the NlpA lipoprotein family
DMB76_RS08995	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DMB76_RS09000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DMB76_RS09005	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DMB76_RS09010	COG0509	glycine decarboxylation via glycine cleavage system
DMB76_RS09015	COG1393	Belongs to the ArsC family
DMB76_RS09020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DMB76_RS09030	COG0710	3-dehydroquinate dehydratase activity
DMB76_RS09035	COG1764	response to oxidative stress
DMB76_RS09080	COG4195	phage-related replication protein
DMB76_RS09095	COG1278	Cold shock
DMB76_RS09155	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DMB76_RS09160	COG0557	exoribonuclease II activity
DMB76_RS09165	COG1647	Serine aminopeptidase, S33
DMB76_RS09170	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DMB76_RS09180	COG0148	phosphopyruvate hydratase activity
DMB76_RS09185	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DMB76_RS09190	COG0149	triose-phosphate isomerase activity
DMB76_RS09195	COG0126	phosphoglycerate kinase activity
DMB76_RS09200	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DMB76_RS09225	COG1090	epimerase
DMB76_RS09235	COG0740	serine-type endopeptidase activity
DMB76_RS09245	COG1481	regulation of sporulation
DMB76_RS09250	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DMB76_RS09255	COG1660	Displays ATPase and GTPase activities
DMB76_RS09260	COG0492	ferredoxin-NADP+ reductase activity
DMB76_RS09275	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DMB76_RS09280	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DMB76_RS09285	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DMB76_RS09290	COG0556	nucleotide-excision repair
DMB76_RS09315	COG0653	protein targeting
DMB76_RS09325	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DMB76_RS09345	COG1739	Uncharacterized protein family UPF0029
DMB76_RS09350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DMB76_RS09355	COG2199	diguanylate cyclase activity
DMB76_RS09370	COG2195	Cleaves the N-terminal amino acid of tripeptides
DMB76_RS09375	COG1929	Belongs to the glycerate kinase type-1 family
DMB76_RS09395	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DMB76_RS09420	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DMB76_RS09425	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DMB76_RS09430	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DMB76_RS09435	COG1780	Probably involved in ribonucleotide reductase function
DMB76_RS09440	COG0697	spore germination
DMB76_RS09445	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DMB76_RS09450	COG3104	oligopeptide transport
DMB76_RS09460	COG1454	alcohol dehydrogenase
DMB76_RS09460	COG1012	belongs to the aldehyde dehydrogenase family
DMB76_RS09475	COG1174	glycine betaine transport
DMB76_RS09485	COG0514	ATP-dependent DNA helicase (RecQ)
DMB76_RS09500	COG1368	sulfuric ester hydrolase activity
DMB76_RS09520	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DMB76_RS09525	COG0512	Glutamine amidotransferase of anthranilate synthase
DMB76_RS09525	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DMB76_RS09530	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DMB76_RS09535	COG0720	synthase
DMB76_RS09540	COG0602	queuosine metabolic process
DMB76_RS09565	COG5002	protein histidine kinase activity
DMB76_RS09570	COG0463	Glycosyl transferase, family 2
DMB76_RS09580	COG1253	flavin adenine dinucleotide binding
DMB76_RS09585	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DMB76_RS09590	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DMB76_RS09590	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DMB76_RS09590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DMB76_RS09595	COG1105	Belongs to the carbohydrate kinase PfkB family
DMB76_RS09600	COG1349	DNA-binding transcription factor activity
DMB76_RS09630	COG0415	Belongs to the DNA photolyase family
DMB76_RS09640	COG0039	L-malate dehydrogenase activity
DMB76_RS09670	COG1968	undecaprenyl-diphosphatase activity
DMB76_RS09680	COG1671	Belongs to the UPF0178 family
DMB76_RS09685	COG1611	Belongs to the LOG family
DMB76_RS09690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DMB76_RS09715	COG2839	Protein conserved in bacteria
DMB76_RS09720	COG2814	Major facilitator Superfamily
DMB76_RS09725	COG0583	DNA-binding transcription factor activity
DMB76_RS09755	COG0217	transcriptional regulatory protein
DMB76_RS09775	COG3942	CHAP domain
DMB76_RS09775	COG1388	LysM domain
DMB76_RS09780	COG0306	phosphate transporter
DMB76_RS09785	COG1392	Phosphate transport regulator
DMB76_RS09790	COG0577	efflux transmembrane transporter activity
DMB76_RS09795	COG1136	(ABC) transporter
DMB76_RS09800	COG2205	protein histidine kinase activity
DMB76_RS09805	COG0745	RESPONSE REGULATOR receiver
DMB76_RS09810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DMB76_RS09820	COG0657	acetylesterase activity
DMB76_RS09825	COG3949	Membrane
DMB76_RS09835	COG1120	ATPase activity
DMB76_RS09845	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DMB76_RS09850	COG1132	(ABC) transporter
DMB76_RS09855	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DMB76_RS09865	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DMB76_RS09870	COG1682	transport, permease protein
DMB76_RS09875	COG1134	teichoic acid transport
DMB76_RS09880	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
DMB76_RS09890	COG1321	iron dependent repressor
DMB76_RS09915	COG1320	monovalent cation:proton antiporter activity
DMB76_RS09925	COG1863	multisubunit Na H antiporter MnhE subunit
DMB76_RS09930	COG0651	ATP synthesis coupled electron transport
DMB76_RS09935	COG1006	Multisubunit Na H antiporter MnhC subunit
DMB76_RS09940	COG2111	Na H antiporter
DMB76_RS09945	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DMB76_RS09945	COG2111	Na H antiporter
DMB76_RS10000	COG0546	phosphoglycolate phosphatase activity
DMB76_RS10010	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DMB76_RS10025	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DMB76_RS10030	COG0018	arginyl-trna synthetase
DMB76_RS10045	COG1064	alcohol dehydrogenase
DMB76_RS10055	COG1078	dGTPase activity
DMB76_RS10065	COG0655	NAD(P)H dehydrogenase (quinone) activity
DMB76_RS10085	COG4844	belongs to the
DMB76_RS10125	COG0095	Lipoate-protein ligase
DMB76_RS10130	COG0280	phosphate acetyltransferase
DMB76_RS10135	COG3253	May function as heme-dependent peroxidase
DMB76_RS10150	COG0531	amino acid
DMB76_RS10155	COG2363	Small membrane protein
DMB76_RS10165	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DMB76_RS10170	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DMB76_RS10185	COG0477	Major facilitator Superfamily
DMB76_RS10215	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DMB76_RS10220	COG0363	glucosamine-6-phosphate deaminase activity
DMB76_RS10225	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DMB76_RS10235	COG1469	GTP cyclohydrolase I activity
DMB76_RS10265	COG0431	NADPH-dependent FMN reductase
DMB76_RS10270	COG0561	phosphatase activity
DMB76_RS10280	COG1428	Deoxynucleoside kinase
DMB76_RS10285	COG1428	Deoxynucleoside kinase
DMB76_RS10300	COG0546	phosphoglycolate phosphatase activity
DMB76_RS10320	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DMB76_RS10355	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DMB76_RS10360	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DMB76_RS10370	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DMB76_RS10380	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DMB76_RS10385	COG0085	RNA polymerase activity
DMB76_RS10390	COG2813	Specifically methylates the guanine in position
DMB76_RS10395	COG0222	ribosome binding
DMB76_RS10400	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DMB76_RS10405	COG0081	regulation of translation
DMB76_RS10410	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DMB76_RS10415	COG0250	Participates in transcription elongation, termination and antitermination
DMB76_RS10420	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DMB76_RS10425	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DMB76_RS10435	COG3688	RNA-binding protein containing a PIN domain
DMB76_RS10440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DMB76_RS10445	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
DMB76_RS10450	COG0215	cysteine-tRNA ligase activity
DMB76_RS10455	COG1045	serine acetyltransferase
DMB76_RS10460	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DMB76_RS10465	COG4956	integral membrane protein (PIN domain superfamily)
DMB76_RS10470	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DMB76_RS10475	COG0542	response to heat
DMB76_RS10480	COG3869	Catalyzes the specific phosphorylation of arginine residues in
DMB76_RS10485	COG3880	PFAM UvrB UvrC protein
DMB76_RS10490	COG4463	regulation of RNA biosynthetic process
DMB76_RS10495	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DMB76_RS10500	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DMB76_RS10505	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DMB76_RS10510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DMB76_RS10585	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DMB76_RS10590	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DMB76_RS10595	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DMB76_RS10600	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DMB76_RS10605	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DMB76_RS10610	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DMB76_RS10615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DMB76_RS10620	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DMB76_RS10625	COG0037	tRNA processing
DMB76_RS10630	COG1098	S1 RNA binding domain
DMB76_RS10640	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DMB76_RS10655	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DMB76_RS10660	COG0193	aminoacyl-tRNA hydrolase activity
DMB76_RS10665	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DMB76_RS10670	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DMB76_RS10675	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DMB76_RS10680	COG2088	sporulation resulting in formation of a cellular spore
DMB76_RS10690	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DMB76_RS10695	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DMB76_RS10700	COG4466	Protein conserved in bacteria
DMB76_RS10705	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DMB76_RS10710	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DMB76_RS10715	COG0084	hydrolase, TatD family'
DMB76_RS10720	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DMB76_RS10720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DMB76_RS10725	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DMB76_RS10730	COG2827	Endonuclease containing a URI domain
DMB76_RS10735	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DMB76_RS10740	COG4467	Involved in initiation control of chromosome replication
DMB76_RS10745	COG1774	PSP1 C-terminal conserved region
DMB76_RS10750	COG0470	DNA polymerase III
DMB76_RS10755	COG3870	Protein conserved in bacteria
DMB76_RS10760	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DMB76_RS10765	COG1982	Orn Lys Arg decarboxylase major
DMB76_RS10795	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DMB76_RS10800	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DMB76_RS10815	COG2188	Transcriptional regulator
DMB76_RS10885	COG1388	LysM domain
DMB76_RS10885	COG3942	CHAP domain
DMB76_RS10895	COG2011	ABC-type metal ion transport system permease component
DMB76_RS10925	COG0733	neurotransmitter:sodium symporter activity
DMB76_RS10935	COG1647	Serine aminopeptidase, S33
DMB76_RS10990	COG2211	Major facilitator Superfamily
DMB76_RS11015	COG0519	Catalyzes the synthesis of GMP from XMP
DMB76_RS11015	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DMB76_RS11020	COG0517	IMP dehydrogenase activity
DMB76_RS11020	COG0516	GMP reductase activity
DMB76_RS11025	COG2233	PERMEase
DMB76_RS11030	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DMB76_RS11045	COG5183	chlorophyll binding
DMB76_RS11070	COG0778	Nitroreductase
DMB76_RS11080	COG0450	alkyl hydroperoxide reductase
DMB76_RS11085	COG3634	alkyl hydroperoxide reductase activity
DMB76_RS11120	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DMB76_RS11130	COG0360	Binds together with S18 to 16S ribosomal RNA
DMB76_RS11145	COG0012	GTP binding
DMB76_RS11150	COG4481	Protein conserved in bacteria
DMB76_RS11155	COG0668	transmembrane transport
DMB76_RS11160	COG1475	DNA binding
DMB76_RS11185	COG0183	Belongs to the thiolase family
DMB76_RS11195	COG1476	TRANSCRIPTIONal
DMB76_RS11230	COG3266	domain, Protein
DMB76_RS11230	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
DMB76_RS11230	COG4932	domain protein
DMB76_RS11240	COG2814	Major facilitator Superfamily
DMB76_RS11260	COG1136	(ABC) transporter
DMB76_RS11265	COG0577	efflux transmembrane transporter activity
DMB76_RS11335	COG0686	Belongs to the AlaDH PNT family
DMB76_RS11345	COG0531	amino acid
DMB76_RS11350	COG1475	DNA binding
DMB76_RS11355	COG0357	Ribosomal RNA small subunit methyltransferase G
DMB76_RS11360	COG0445	tRNA wobble uridine modification
DMB76_RS11365	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DMB76_RS11370	COG0594	ribonuclease P activity
DMB76_RS11400	COG1169	isochorismate synthase
DMB76_RS11435	COG0736	holo-[acyl-carrier-protein] synthase activity
DMB76_RS11440	COG0500	methyltransferase
DMB76_RS11440	COG3615	Tellurite resistance protein tehB