locus-tag	class	description
I6I26_RS00030	COG1475	DNA binding
I6I26_RS00035	COG0357	Ribosomal RNA small subunit methyltransferase G
I6I26_RS00040	COG0445	tRNA wobble uridine modification
I6I26_RS00045	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6I26_RS00050	COG0594	ribonuclease P activity
I6I26_RS00060	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I26_RS00065	COG0592	DNA-directed DNA polymerase activity
I6I26_RS00070	COG2501	S4 domain
I6I26_RS00075	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I26_RS00090	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6I26_RS00105	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6I26_RS00115	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I26_RS00125	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I6I26_RS00130	COG0359	binds to the 23S rRNA
I6I26_RS00135	COG0305	Participates in initiation and elongation during chromosome replication
I6I26_RS00140	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6I26_RS00155	COG0745	RESPONSE REGULATOR receiver
I6I26_RS00160	COG5002	protein histidine kinase activity
I6I26_RS00175	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6I26_RS00185	COG4195	phage-related replication protein
I6I26_RS00190	COG0702	epimerase
I6I26_RS00210	COG0561	phosphatase activity
I6I26_RS00240	COG2814	Major facilitator Superfamily
I6I26_RS00285	COG3223	Belongs to the PsiE family
I6I26_RS00295	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I26_RS00295	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I26_RS00360	COG2851	Citrate transporter
I6I26_RS00365	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I6I26_RS00370	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6I26_RS00375	COG0577	efflux transmembrane transporter activity
I6I26_RS00375	COG1136	(ABC) transporter
I6I26_RS00425	COG0110	maltose O-acetyltransferase activity
I6I26_RS00430	COG1114	Component of the transport system for branched-chain amino acids
I6I26_RS00435	COG2814	Major facilitator Superfamily
I6I26_RS00440	COG1335	isochorismatase
I6I26_RS00470	COG1869	D-ribose catabolic process
I6I26_RS00485	COG0604	alcohol dehydrogenase
I6I26_RS00500	COG1131	(ABC) transporter
I6I26_RS00530	COG0601	transmembrane transport
I6I26_RS00540	COG0444	Belongs to the ABC transporter superfamily
I6I26_RS00545	COG1124	(ABC) transporter
I6I26_RS00555	COG1418	mRNA catabolic process
I6I26_RS00570	COG0405	Gamma-glutamyltransferase
I6I26_RS00580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I26_RS00585	COG0601	transmembrane transport
I6I26_RS00595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I26_RS00615	COG2235	arginine
I6I26_RS00620	COG1438	arginine binding
I6I26_RS00630	COG0438	transferase activity, transferring glycosyl groups
I6I26_RS00635	COG0653	protein targeting
I6I26_RS00645	COG1073	alpha beta
I6I26_RS00655	COG0201	protein transport
I6I26_RS00675	COG1686	Belongs to the peptidase S11 family
I6I26_RS00680	COG2910	NAD(P)H-binding
I6I26_RS00685	COG1876	peptidase activity
I6I26_RS00690	COG1882	Formate acetyltransferase
I6I26_RS00695	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6I26_RS00705	COG0431	NADPH-dependent FMN reductase
I6I26_RS00705	COG3976	FMN-binding domain protein
I6I26_RS00705	COG1053	succinate dehydrogenase
I6I26_RS00715	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I26_RS00720	COG0463	Glycosyl transferase, family 2
I6I26_RS00720	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6I26_RS00740	COG1131	(ABC) transporter
I6I26_RS00825	COG1136	(ABC) transporter
I6I26_RS00835	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I26_RS00840	COG4221	oxidoreductase activity
I6I26_RS00845	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I6I26_RS00850	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
I6I26_RS00855	COG2962	Rard protein
I6I26_RS00860	COG0471	metal ion transport
I6I26_RS00875	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I6I26_RS00880	COG3711	transcriptional antiterminator
I6I26_RS00885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I26_RS00920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I26_RS00935	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I6I26_RS00940	COG1054	Belongs to the UPF0176 family
I6I26_RS00955	COG0477	Major facilitator Superfamily
I6I26_RS00975	COG1288	antiporter activity
I6I26_RS00980	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6I26_RS01005	COG2814	Major facilitator Superfamily
I6I26_RS01035	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6I26_RS01105	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I26_RS01115	COG1309	transcriptional regulator
I6I26_RS01125	COG2113	Glycine betaine
I6I26_RS01130	COG2409	Drug exporters of the RND superfamily
I6I26_RS01135	COG1764	response to oxidative stress
I6I26_RS01145	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6I26_RS01145	COG3942	CHAP domain
I6I26_RS01160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I26_RS01170	COG3227	Zinc metalloprotease (Elastase)
I6I26_RS01185	COG3961	Belongs to the TPP enzyme family
I6I26_RS01200	COG1785	Belongs to the alkaline phosphatase family
I6I26_RS01210	COG0745	RESPONSE REGULATOR receiver
I6I26_RS01215	COG2205	protein histidine kinase activity
I6I26_RS01220	COG1136	(ABC) transporter
I6I26_RS01225	COG0577	efflux transmembrane transporter activity
I6I26_RS01265	COG3942	CHAP domain
I6I26_RS01270	COG1328	CTP reductase activity
I6I26_RS01275	COG0602	queuosine metabolic process
I6I26_RS01280	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6I26_RS01290	COG1510	regulation of RNA biosynthetic process
I6I26_RS01295	COG1012	belongs to the aldehyde dehydrogenase family
I6I26_RS01300	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6I26_RS01305	COG1473	amidohydrolase
I6I26_RS01320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I26_RS01325	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I26_RS01325	COG0574	Belongs to the PEP-utilizing enzyme family
I6I26_RS01330	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6I26_RS01335	COG0579	oxidoreductase
I6I26_RS01340	COG2723	6-phospho-beta-galactosidase activity
I6I26_RS01350	COG0583	DNA-binding transcription factor activity
I6I26_RS01365	COG3588	fructose-bisphosphate aldolase
I6I26_RS01370	COG0563	adenylate kinase activity
I6I26_RS01380	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I26_RS01400	COG0531	amino acid
I6I26_RS01410	COG0583	DNA-binding transcription factor activity
I6I26_RS01415	COG0039	L-malate dehydrogenase activity
I6I26_RS01420	COG0028	Belongs to the TPP enzyme family
I6I26_RS01425	COG3527	Alpha-acetolactate decarboxylase
I6I26_RS01435	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6I26_RS01440	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6I26_RS01480	COG2801	Transposase and inactivated derivatives
I6I26_RS01500	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6I26_RS01510	COG0167	dihydroorotate dehydrogenase activity
I6I26_RS01515	COG3001	Fructosamine kinase
I6I26_RS01570	COG1113	amino acid transport
I6I26_RS01575	COG3189	MarR family transcriptional regulator
I6I26_RS01590	COG0741	lytic transglycosylase activity
I6I26_RS01610	COG1562	ergosterol biosynthetic process
I6I26_RS01620	COG0436	Aminotransferase
I6I26_RS01630	COG2608	mercury ion transmembrane transporter activity
I6I26_RS01645	COG1028	Short-chain dehydrogenase reductase Sdr
I6I26_RS01655	COG1012	belongs to the aldehyde dehydrogenase family
I6I26_RS01670	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I26_RS01675	COG3425	synthase
I6I26_RS01695	COG0583	DNA-binding transcription factor activity
I6I26_RS01700	COG1380	Effector of murein hydrolase LrgA
I6I26_RS01705	COG1346	cytolysis
I6I26_RS01710	COG0028	Belongs to the TPP enzyme family
I6I26_RS01730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I26_RS01735	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6I26_RS01750	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6I26_RS01760	COG2843	Capsule synthesis protein
I6I26_RS01795	COG1760	l-serine dehydratase
I6I26_RS01800	COG1760	l-serine dehydratase
I6I26_RS01815	COG3764	Sortase (surface protein transpeptidase)
I6I26_RS01825	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I26_RS01830	COG0778	Nitroreductase
I6I26_RS01835	COG1012	belongs to the aldehyde dehydrogenase family
I6I26_RS01840	COG2514	catechol 2,3-dioxygenase activity
I6I26_RS01850	COG1012	belongs to the aldehyde dehydrogenase family
I6I26_RS01855	COG3949	Membrane
I6I26_RS01870	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
I6I26_RS01875	COG0586	Pfam SNARE associated Golgi protein
I6I26_RS01880	COG2271	Major facilitator Superfamily
I6I26_RS01895	COG4876	unkown
I6I26_RS01900	COG2357	RelA SpoT domain protein
I6I26_RS01905	COG1802	Transcriptional regulator
I6I26_RS01910	COG1070	Carbohydrate kinase
I6I26_RS01915	COG2610	gluconate transmembrane transporter activity
I6I26_RS01920	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I26_RS01930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I26_RS01935	COG0438	transferase activity, transferring glycosyl groups
I6I26_RS01940	COG0494	nUDIX hydrolase
I6I26_RS01980	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6I26_RS01990	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6I26_RS01995	COG1028	Short-chain dehydrogenase reductase Sdr
I6I26_RS02005	COG1363	Peptidase, m42
I6I26_RS02010	COG4808	Protein conserved in bacteria
I6I26_RS02025	COG0069	glutamate synthase activity
I6I26_RS02040	COG2205	protein histidine kinase activity
I6I26_RS02045	COG0745	RESPONSE REGULATOR receiver
I6I26_RS02055	COG2814	Major facilitator Superfamily
I6I26_RS02060	COG2272	Belongs to the type-B carboxylesterase lipase family
I6I26_RS02065	COG0531	amino acid
I6I26_RS02070	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
I6I26_RS02095	COG1174	glycine betaine transport
I6I26_RS02100	COG1346	cytolysis
I6I26_RS02105	COG1380	Effector of murein hydrolase LrgA
I6I26_RS02115	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6I26_RS02130	COG0706	membrane insertase activity
I6I26_RS02135	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I26_RS02140	COG0531	amino acid
I6I26_RS02150	COG1113	amino acid transport
I6I26_RS02155	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6I26_RS02170	COG2814	Major facilitator Superfamily
I6I26_RS02180	COG1929	Belongs to the glycerate kinase type-1 family
I6I26_RS02195	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6I26_RS02200	COG0741	lytic transglycosylase activity
I6I26_RS02205	COG0588	phosphoglycerate mutase activity
I6I26_RS02215	COG2814	Major facilitator Superfamily
I6I26_RS02220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I26_RS02225	COG0765	amino acid transport
I6I26_RS02230	COG1126	abc transporter atp-binding protein
I6I26_RS02250	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6I26_RS02270	COG0454	-acetyltransferase
I6I26_RS02280	COG0747	negative chemotaxis
I6I26_RS02290	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I26_RS02295	COG2146	nitrite reductase [NAD(P)H] activity
I6I26_RS02305	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6I26_RS02310	COG1140	nitrate reductase beta subunit
I6I26_RS02320	COG2181	nitrate reductase activity
I6I26_RS02330	COG4585	Histidine kinase
I6I26_RS02340	COG2223	nitrite transmembrane transporter activity
I6I26_RS02355	COG0778	Nitroreductase
I6I26_RS02390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I26_RS02390	COG1263	PTS System
I6I26_RS02400	COG1309	transcriptional regulator
I6I26_RS02410	COG1028	Short-chain dehydrogenase reductase Sdr
I6I26_RS02415	COG0583	DNA-binding transcription factor activity
I6I26_RS02420	COG2610	gluconate transmembrane transporter activity
I6I26_RS02425	COG1028	Short-chain dehydrogenase reductase Sdr
I6I26_RS02460	COG0492	ferredoxin-NADP+ reductase activity
I6I26_RS02465	COG0456	acetyltransferase
I6I26_RS02470	COG0604	alcohol dehydrogenase
I6I26_RS02475	COG2822	iron ion transport
I6I26_RS02480	COG2837	iron assimilation
I6I26_RS02485	COG0672	)-iron permease
I6I26_RS02490	COG0805	protein transport
I6I26_RS02495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I26_RS02505	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6I26_RS02505	COG0463	Glycosyl transferase, family 2
I6I26_RS02515	COG0463	Glycosyl transferase, family 2
I6I26_RS02515	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6I26_RS02520	COG1620	l-lactate permease
I6I26_RS02525	COG0297	glycogen (starch) synthase activity
I6I26_RS02530	COG0579	oxidoreductase
I6I26_RS02555	COG0577	efflux transmembrane transporter activity
I6I26_RS02575	COG4640	response to antibiotic
I6I26_RS02580	COG2814	Major facilitator Superfamily
I6I26_RS02590	COG1566	PFAM secretion protein HlyD family protein
I6I26_RS02595	COG2814	Major facilitator Superfamily
I6I26_RS02620	COG0598	Magnesium transport protein CorA
I6I26_RS02625	COG1304	FMN binding
I6I26_RS02630	COG0786	glutamate:sodium symporter activity
I6I26_RS02635	COG1695	Transcriptional regulator
I6I26_RS02650	COG2094	Belongs to the DNA glycosylase MPG family
I6I26_RS02660	COG1396	sequence-specific DNA binding
I6I26_RS02670	COG1069	ribulokinase activity
I6I26_RS02675	COG4152	abc transporter atp-binding protein
I6I26_RS02680	COG1668	transmembrane transport
I6I26_RS02685	COG1742	UPF0060 membrane protein
I6I26_RS02690	COG2017	converts alpha-aldose to the beta-anomer
I6I26_RS02700	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6I26_RS02710	COG1266	CAAX protease self-immunity
I6I26_RS02715	COG0010	Belongs to the arginase family
I6I26_RS02720	COG0583	DNA-binding transcription factor activity
I6I26_RS02735	COG0659	secondary active sulfate transmembrane transporter activity
I6I26_RS02740	COG1473	amidohydrolase
I6I26_RS02745	COG1028	Short-chain dehydrogenase reductase Sdr
I6I26_RS02765	COG1737	Transcriptional regulator
I6I26_RS02770	COG1263	PTS System
I6I26_RS02770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I26_RS02780	COG0385	Bile acid
I6I26_RS02785	COG0546	phosphoglycolate phosphatase activity
I6I26_RS02805	COG1113	amino acid transport
I6I26_RS02810	COG1737	Transcriptional regulator
I6I26_RS02815	COG1263	PTS System
I6I26_RS02815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I26_RS02820	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6I26_RS02845	COG1316	TRANSCRIPTIONal
I6I26_RS02875	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I26_RS02880	COG2076	Multidrug Resistance protein
I6I26_RS02885	COG2076	Multidrug Resistance protein
I6I26_RS02890	COG3942	CHAP domain
I6I26_RS02905	COG1757	Na H antiporter
I6I26_RS02910	COG3942	CHAP domain
I6I26_RS02920	COG1846	Transcriptional regulator
I6I26_RS02935	COG0829	nickel cation binding
I6I26_RS02940	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6I26_RS02945	COG0830	nickel cation binding
I6I26_RS02950	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
I6I26_RS02955	COG0804	urea catabolic process
I6I26_RS02965	COG0831	urea catabolic process
I6I26_RS02970	COG4413	Urea transporter
I6I26_RS02975	COG0765	amino acid transport
I6I26_RS02980	COG0765	amino acid transport
I6I26_RS02985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I26_RS02990	COG1126	abc transporter atp-binding protein
I6I26_RS02995	COG1960	acyl-CoA dehydrogenase activity
I6I26_RS03000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I26_RS03005	COG1957	nucleoside hydrolase
I6I26_RS03010	COG1268	BioY protein
I6I26_RS03020	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6I26_RS03025	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6I26_RS03030	COG4149	molybdate abc transporter
I6I26_RS03035	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6I26_RS03040	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6I26_RS03050	COG0315	cyclic pyranopterin monophosphate synthase activity
I6I26_RS03080	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6I26_RS03090	COG2814	Major facilitator Superfamily
I6I26_RS03110	COG2348	transferase activity, transferring amino-acyl groups
I6I26_RS03115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I26_RS03140	COG4975	Glucose uptake
I6I26_RS03150	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6I26_RS03150	COG0551	DNA topoisomerase type I activity
I6I26_RS03155	COG2252	PERMEase
I6I26_RS03170	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6I26_RS03175	COG0088	Forms part of the polypeptide exit tunnel
I6I26_RS03180	COG0089	rRNA binding
I6I26_RS03185	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6I26_RS03190	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6I26_RS03195	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6I26_RS03200	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6I26_RS03205	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6I26_RS03215	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6I26_RS03220	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6I26_RS03225	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6I26_RS03235	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6I26_RS03240	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6I26_RS03245	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6I26_RS03250	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6I26_RS03255	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6I26_RS03260	COG1841	ribosomal large subunit assembly
I6I26_RS03270	COG0201	protein transport
I6I26_RS03275	COG0563	adenylate kinase activity
I6I26_RS03280	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6I26_RS03290	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6I26_RS03295	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6I26_RS03300	COG0202	RNA polymerase activity
I6I26_RS03305	COG0203	ribosomal protein L17
I6I26_RS03315	COG1122	ATPase activity
I6I26_RS03325	COG0101	tRNA pseudouridine synthase activity
I6I26_RS03330	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6I26_RS03340	COG0789	Transcriptional regulator
I6I26_RS03355	COG0698	ribose 5-phosphate isomerase
I6I26_RS03395	COG2130	NADP-dependent
I6I26_RS03400	COG0604	alcohol dehydrogenase
I6I26_RS03415	COG1302	Protein conserved in bacteria
I6I26_RS03420	COG4264	IucA IucC family
I6I26_RS03425	COG2814	Major facilitator Superfamily
I6I26_RS03430	COG4264	IucA IucC family
I6I26_RS03435	COG3457	Alanine racemase
I6I26_RS03440	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6I26_RS03445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I26_RS03450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I26_RS03455	COG3314	Sporulation integral membrane protein YlbJ
I6I26_RS03460	COG2329	Antibiotic biosynthesis monooxygenase
I6I26_RS03470	COG1988	membrane-bound metal-dependent
I6I26_RS03475	COG4284	Utp--glucose-1-phosphate uridylyltransferase
I6I26_RS03480	COG1272	protein, Hemolysin III
I6I26_RS03495	COG2814	Major facilitator Superfamily
I6I26_RS03500	COG0489	protein tyrosine kinase activity
I6I26_RS03555	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I6I26_RS03580	COG3711	transcriptional antiterminator
I6I26_RS03595	COG0561	phosphatase activity
I6I26_RS03615	COG0640	Transcriptional regulator
I6I26_RS03620	COG0702	epimerase
I6I26_RS03625	COG1482	cell wall glycoprotein biosynthetic process
I6I26_RS03645	COG0783	Belongs to the Dps family
I6I26_RS03650	COG0813	purine-nucleoside phosphorylase activity
I6I26_RS03655	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6I26_RS03660	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6I26_RS03665	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6I26_RS03675	COG1854	S-ribosylhomocysteine lyase activity
I6I26_RS03695	COG5146	pantothenate kinase activity
I6I26_RS03710	COG0504	CTP synthase activity
I6I26_RS03720	COG0191	fructose-bisphosphate aldolase activity
I6I26_RS03725	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6I26_RS03735	COG1012	belongs to the aldehyde dehydrogenase family
I6I26_RS03740	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6I26_RS03745	COG0254	rRNA binding
I6I26_RS03750	COG1435	thymidine kinase activity
I6I26_RS03755	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6I26_RS03760	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I26_RS03765	COG0009	L-threonylcarbamoyladenylate synthase
I6I26_RS03770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I26_RS03775	COG4475	Protein of unknown function (DUF436)
I6I26_RS03785	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6I26_RS03790	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6I26_RS03815	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6I26_RS03835	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6I26_RS03845	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6I26_RS03850	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I26_RS03860	COG0629	single-stranded DNA binding
I6I26_RS03870	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6I26_RS03880	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6I26_RS03885	COG0352	thiamine-phosphate diphosphorylase activity
I6I26_RS03890	COG0706	membrane insertase activity
I6I26_RS03895	COG1418	mRNA catabolic process
I6I26_RS03900	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I26_RS03905	COG1937	Protein conserved in bacteria
I6I26_RS03920	COG0772	Belongs to the SEDS family
I6I26_RS03925	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I26_RS03930	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6I26_RS03935	COG0513	Belongs to the DEAD box helicase family
I6I26_RS03945	COG3428	Bacterial PH domain
I6I26_RS03950	COG3402	PFAM membrane-flanked domain
I6I26_RS03955	COG0736	holo-[acyl-carrier-protein] synthase activity
I6I26_RS03960	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I26_RS03970	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6I26_RS03990	COG1191	sigma factor activity
I6I26_RS03995	COG2183	response to ionizing radiation
I6I26_RS04000	COG3091	SprT-like family
I6I26_RS04040	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6I26_RS04045	COG0473	3-isopropylmalate dehydrogenase activity
I6I26_RS04050	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I26_RS04065	COG0028	Belongs to the TPP enzyme family
I6I26_RS04070	COG0129	dihydroxy-acid dehydratase activity
I6I26_RS04075	COG0802	atpase or kinase
I6I26_RS04080	COG1214	PFAM Peptidase M22, glycoprotease
I6I26_RS04085	COG0456	acetyltransferase
I6I26_RS04090	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6I26_RS04095	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6I26_RS04100	COG0488	(ABC) transporter
I6I26_RS04105	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I6I26_RS04115	COG2391	methyltransferase activity
I6I26_RS04120	COG0425	Belongs to the sulfur carrier protein TusA family
I6I26_RS04125	COG0004	ammonium transporteR
I6I26_RS04130	COG1609	Transcriptional regulator
I6I26_RS04135	COG1621	beta-fructofuranosidase activity
I6I26_RS04140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I26_RS04195	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6I26_RS04200	COG0459	protein refolding
I6I26_RS04205	COG0582	viral genome integration into host DNA
I6I26_RS04355	COG0436	Aminotransferase
I6I26_RS04365	COG1725	Transcriptional regulator
I6I26_RS04370	COG1131	(ABC) transporter
I6I26_RS04380	COG1131	(ABC) transporter
I6I26_RS04430	COG4974	Belongs to the 'phage' integrase family
I6I26_RS04460	COG3682	Transcriptional regulator
I6I26_RS04465	COG2706	6-phosphogluconolactonase activity
I6I26_RS04470	COG1012	belongs to the aldehyde dehydrogenase family
I6I26_RS04475	COG1227	inorganic diphosphatase activity
I6I26_RS04480	COG1335	isochorismatase
I6I26_RS04490	COG0077	Prephenate dehydratase
I6I26_RS04500	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6I26_RS04505	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6I26_RS04510	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
I6I26_RS04520	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6I26_RS04525	COG4496	protein, YerC YecD
I6I26_RS04535	COG0210	DNA helicase
I6I26_RS04540	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6I26_RS04550	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I26_RS04565	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I26_RS04575	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I26_RS04585	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I26_RS04595	COG1528	Iron-storage protein
I6I26_RS04610	COG4129	membrane
I6I26_RS04615	COG0024	Methionine aminopeptidase
I6I26_RS04635	COG2197	response regulator
I6I26_RS04640	COG1295	ribonuclease BN
I6I26_RS04655	COG4840	Belongs to the UPF0435 family
I6I26_RS04660	COG2309	aminopeptidase activity
I6I26_RS04665	COG1607	acyl-coa hydrolase
I6I26_RS04670	COG0535	radical SAM domain protein
I6I26_RS04685	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I26_RS04700	COG1388	LysM domain
I6I26_RS04700	COG1134	teichoic acid transport
I6I26_RS04710	COG1988	membrane-bound metal-dependent
I6I26_RS04715	COG1194	a g-specific adenine glycosylase
I6I26_RS04720	COG3557	Belongs to the UPF0374 family
I6I26_RS04730	COG4129	membrane
I6I26_RS04735	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6I26_RS04740	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I26_RS04745	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I26_RS04750	COG0735	belongs to the Fur family
I6I26_RS04920	COG0765	amino acid transport
I6I26_RS04925	COG1126	abc transporter atp-binding protein
I6I26_RS04930	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6I26_RS04940	COG0363	glucosamine-6-phosphate deaminase activity
I6I26_RS04955	COG0114	fumarate hydratase activity
I6I26_RS04960	COG0564	pseudouridine synthase activity
I6I26_RS04965	COG4585	Histidine kinase
I6I26_RS04965	COG2203	Gaf domain
I6I26_RS04970	COG2197	response regulator
I6I26_RS04980	COG4399	Belongs to the UPF0754 family
I6I26_RS04985	COG3679	Belongs to the UPF0342 family
I6I26_RS04990	COG0420	3'-5' exonuclease activity
I6I26_RS05000	COG3481	metal-dependent phosphohydrolase, HD sub domain
I6I26_RS05010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I26_RS05025	COG0537	adenosine 5'-monophosphoramidase activity
I6I26_RS05030	COG1131	(ABC) transporter
I6I26_RS05035	COG4473	ABC transporter
I6I26_RS05040	COG2329	Antibiotic biosynthesis monooxygenase
I6I26_RS05050	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6I26_RS05055	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6I26_RS05060	COG3545	Serine hydrolase
I6I26_RS05115	COG0318	PFAM AMP-dependent synthetase and ligase
I6I26_RS05135	COG1506	peptidase
I6I26_RS05145	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6I26_RS05155	COG0656	L-ascorbic acid biosynthetic process
I6I26_RS05160	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I26_RS05165	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I26_RS05175	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I26_RS05190	COG1595	DNA-templated transcription, initiation
I6I26_RS05200	COG3266	domain, Protein
I6I26_RS05200	COG4193	domain, Protein
I6I26_RS05200	COG5632	N-Acetylmuramoyl-L-alanine amidase
I6I26_RS05210	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I26_RS05210	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I26_RS05215	COG0307	riboflavin synthase, alpha
I6I26_RS05220	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6I26_RS05220	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6I26_RS05225	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6I26_RS05230	COG0506	proline dehydrogenase activity
I6I26_RS05235	COG2267	carboxylic ester hydrolase activity
I6I26_RS05245	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6I26_RS05250	COG1242	4 iron, 4 sulfur cluster binding
I6I26_RS05255	COG2814	Major facilitator Superfamily
I6I26_RS05260	COG0495	leucyl-tRNA aminoacylation
I6I26_RS05265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I26_RS05280	COG2081	HI0933 family
I6I26_RS05285	COG2244	polysaccharide biosynthetic process
I6I26_RS05290	COG1187	pseudouridine synthase activity
I6I26_RS05300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I26_RS05305	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I26_RS05310	COG0510	thiamine kinase activity
I6I26_RS05315	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6I26_RS05320	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
I6I26_RS05325	COG2226	methyltransferase
I6I26_RS05330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I26_RS05340	COG1363	Peptidase, m42
I6I26_RS05345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I26_RS05350	COG4848	Belongs to the UPF0354 family
I6I26_RS05355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I26_RS05360	COG1674	ftsk spoiiie
I6I26_RS05365	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I26_RS05380	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I6I26_RS05380	COG1605	Chorismate mutase
I6I26_RS05385	COG1609	Transcriptional regulator
I6I26_RS05395	COG0454	-acetyltransferase
I6I26_RS05410	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6I26_RS05415	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6I26_RS05425	COG0477	Major facilitator Superfamily
I6I26_RS05430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I26_RS05435	COG0204	Acyl-transferase
I6I26_RS05445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I26_RS05445	COG1263	PTS System
I6I26_RS05455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I26_RS05460	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6I26_RS05465	COG1764	response to oxidative stress
I6I26_RS05470	COG0584	glycerophosphoryl diester phosphodiesterase
I6I26_RS05475	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6I26_RS05480	COG1956	GAF domain-containing protein
I6I26_RS05485	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I6I26_RS05490	COG1104	cysteine desulfurase activity
I6I26_RS05495	COG0301	tRNA thio-modification
I6I26_RS05515	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6I26_RS05520	COG0589	response to stress
I6I26_RS05530	COG0006	proline dipeptidase activity
I6I26_RS05535	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6I26_RS05545	COG4109	DRTGG domain
I6I26_RS05550	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6I26_RS05555	COG0587	DNA-directed DNA polymerase activity
I6I26_RS05560	COG0281	malic enzyme
I6I26_RS05565	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6I26_RS05575	COG0205	6-phosphofructokinase activity
I6I26_RS05580	COG0469	pyruvate kinase activity
I6I26_RS05585	COG1113	amino acid transport
I6I26_RS05590	COG0372	Belongs to the citrate synthase family
I6I26_RS05595	COG0538	isocitrate dehydrogenase activity
I6I26_RS05600	COG0745	RESPONSE REGULATOR receiver
I6I26_RS05605	COG5002	protein histidine kinase activity
I6I26_RS05610	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I26_RS05610	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I26_RS05615	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6I26_RS05625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6I26_RS05630	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6I26_RS05635	COG3611	Membrane attachment protein
I6I26_RS05640	COG1484	DNA-dependent DNA replication
I6I26_RS05645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6I26_RS05650	COG0833	amino acid
I6I26_RS05655	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6I26_RS05660	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6I26_RS05665	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6I26_RS05670	COG4112	unkown
I6I26_RS05680	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6I26_RS05685	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6I26_RS05695	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6I26_RS05700	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6I26_RS05705	COG0181	hydroxymethylbilane synthase activity
I6I26_RS05715	COG0113	porphobilinogen synthase activity
I6I26_RS05720	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6I26_RS05725	COG3180	Ammonia monooxygenase
I6I26_RS05730	COG2818	Glycosylase
I6I26_RS05735	COG0525	valine-tRNA ligase activity
I6I26_RS05740	COG0285	dihydrofolate synthase activity
I6I26_RS05750	COG2003	Belongs to the UPF0758 family
I6I26_RS05785	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6I26_RS05790	COG2868	ribosomal protein
I6I26_RS05795	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6I26_RS05800	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6I26_RS05805	COG4492	Belongs to the UPF0735 family
I6I26_RS05810	COG0632	four-way junction helicase activity
I6I26_RS05820	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6I26_RS05830	COG1862	Preprotein translocase
I6I26_RS05835	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I26_RS05835	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I26_RS05840	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6I26_RS05840	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6I26_RS05850	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I26_RS05860	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I26_RS05870	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6I26_RS05880	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6I26_RS05885	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6I26_RS05890	COG1959	2 iron, 2 sulfur cluster binding
I6I26_RS05900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I26_RS05905	COG1104	cysteine desulfurase activity
I6I26_RS05910	COG0482	sulfurtransferase activity
I6I26_RS05920	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I26_RS05925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I26_RS05930	COG4472	Bacterial protein of unknown function (DUF965)
I6I26_RS05935	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6I26_RS05940	COG3906	Belongs to the UPF0473 family
I6I26_RS05945	COG4122	O-methyltransferase activity
I6I26_RS05950	COG0826	peptidase U32
I6I26_RS05955	COG0826	peptidase U32
I6I26_RS05960	COG0572	uridine kinase
I6I26_RS05965	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I26_RS05970	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6I26_RS05975	COG1984	allophanate hydrolase subunit 2
I6I26_RS05980	COG0511	ligase activity, forming carbon-carbon bonds
I6I26_RS05985	COG0439	Biotin carboxylase
I6I26_RS05990	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6I26_RS05995	COG1914	H( )-stimulated, divalent metal cation uptake system
I6I26_RS06000	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6I26_RS06005	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I6I26_RS06010	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6I26_RS06015	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I26_RS06020	COG1534	Rna-binding protein
I6I26_RS06025	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6I26_RS06030	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6I26_RS06035	COG0799	negative regulation of ribosome biogenesis
I6I26_RS06040	COG2226	methyltransferase
I6I26_RS06045	COG2183	response to ionizing radiation
I6I26_RS06050	COG2131	deaminase
I6I26_RS06060	COG1466	dna polymerase III delta subunit
I6I26_RS06065	COG0268	Binds directly to 16S ribosomal RNA
I6I26_RS06070	COG0481	GTPase activity
I6I26_RS06075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I26_RS06085	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6I26_RS06090	COG0443	Heat shock 70 kDa protein
I6I26_RS06095	COG0484	heat shock protein binding
I6I26_RS06105	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6I26_RS06110	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I26_RS06120	COG1030	water channel activity
I6I26_RS06125	COG4864	UPF0365 protein
I6I26_RS06135	COG1702	phosphate starvation-inducible protein PhoH
I6I26_RS06145	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6I26_RS06155	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6I26_RS06160	COG1381	Involved in DNA repair and RecF pathway recombination
I6I26_RS06165	COG0423	glycine-tRNA ligase activity
I6I26_RS06170	COG0517	IMP dehydrogenase activity
I6I26_RS06175	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6I26_RS06185	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6I26_RS06190	COG2384	SAM-dependent methyltransferase
I6I26_RS06195	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6I26_RS06200	COG0513	Belongs to the DEAD box helicase family
I6I26_RS06205	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6I26_RS06210	COG1121	(ABC) transporter
I6I26_RS06215	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I26_RS06230	COG0768	penicillin binding
I6I26_RS06235	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6I26_RS06240	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6I26_RS06250	COG4483	Protein conserved in bacteria
I6I26_RS06255	COG1940	carbohydrate kinase activity
I6I26_RS06260	COG0011	TIGRFAM Protein of
I6I26_RS06265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I26_RS06270	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6I26_RS06280	COG4537	Required for transformation and DNA binding
I6I26_RS06295	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6I26_RS06300	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6I26_RS06315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I26_RS06320	COG0095	Lipoate-protein ligase
I6I26_RS06335	COG0006	proline dipeptidase activity
I6I26_RS06340	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I26_RS06350	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6I26_RS06355	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6I26_RS06360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I26_RS06365	COG0511	ligase activity, forming carbon-carbon bonds
I6I26_RS06370	COG0439	Biotin carboxylase
I6I26_RS06375	COG1302	Protein conserved in bacteria
I6I26_RS06380	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I26_RS06390	COG1722	exodeoxyribonuclease VII activity
I6I26_RS06400	COG1438	arginine binding
I6I26_RS06405	COG0497	DNA recombination
I6I26_RS06410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I26_RS06415	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6I26_RS06420	COG0022	dehydrogenase e1 component
I6I26_RS06425	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I26_RS06435	COG4129	membrane
I6I26_RS06440	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6I26_RS06445	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6I26_RS06450	COG0366	Alpha amylase catalytic
I6I26_RS06460	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6I26_RS06470	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6I26_RS06475	COG0300	oxidoreductase activity
I6I26_RS06480	COG0667	Aldo Keto reductase
I6I26_RS06485	COG0494	nUDIX hydrolase
I6I26_RS06490	COG0735	belongs to the Fur family
I6I26_RS06495	COG4974	Belongs to the 'phage' integrase family
I6I26_RS06510	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6I26_RS06515	COG1187	pseudouridine synthase activity
I6I26_RS06520	COG0745	RESPONSE REGULATOR receiver
I6I26_RS06535	COG1141	Ferredoxin
I6I26_RS06545	COG0514	ATP-dependent DNA helicase (RecQ)
I6I26_RS06555	COG0492	ferredoxin-NADP+ reductase activity
I6I26_RS06560	COG0252	asparaginase activity
I6I26_RS06565	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6I26_RS06570	COG0539	negative regulation of cytoplasmic translation
I6I26_RS06575	COG1160	GTP binding
I6I26_RS06580	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6I26_RS06595	COG2226	methyltransferase
I6I26_RS06600	COG0142	geranyltranstransferase activity
I6I26_RS06610	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6I26_RS06615	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6I26_RS06620	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6I26_RS06630	COG5582	Belongs to the UPF0302 family
I6I26_RS06635	COG4347	Protein of unknown function (DUF1405)
I6I26_RS06640	COG2738	Putative neutral zinc metallopeptidase
I6I26_RS06645	COG1694	Mazg nucleotide pyrophosphohydrolase
I6I26_RS06650	COG0438	transferase activity, transferring glycosyl groups
I6I26_RS06655	COG0617	tRNA 3'-terminal CCA addition
I6I26_RS06665	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I26_RS06665	COG1199	ATP-dependent helicase activity
I6I26_RS06670	COG0017	Asparaginyl-tRNA synthetase
I6I26_RS06675	COG3935	DnaD domain protein
I6I26_RS06680	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6I26_RS06690	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6I26_RS06690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I26_RS06695	COG3331	DNA recombination
I6I26_RS06710	COG3599	regulation of cell shape
I6I26_RS06720	COG0116	Belongs to the methyltransferase superfamily
I6I26_RS06730	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6I26_RS06735	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I26_RS06750	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6I26_RS06760	COG1413	lyase activity
I6I26_RS06765	COG1413	lyase activity
I6I26_RS06795	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I26_RS06800	COG2190	(PTS) system
I6I26_RS06810	COG0793	Belongs to the peptidase S41A family
I6I26_RS06820	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I26_RS06825	COG0671	phosphoesterase, PA-phosphatase related
I6I26_RS06830	COG1733	regulation of RNA biosynthetic process
I6I26_RS06845	COG0745	RESPONSE REGULATOR receiver
I6I26_RS06850	COG5002	protein histidine kinase activity
I6I26_RS06855	COG0567	Dehydrogenase, E1 component
I6I26_RS06865	COG1131	(ABC) transporter
I6I26_RS06890	COG0714	Associated with various cellular activities
I6I26_RS06895	COG4548	von Willebrand factor, type A
I6I26_RS06900	COG1114	Component of the transport system for branched-chain amino acids
I6I26_RS06905	COG3853	Toxic anion resistance protein (TelA)
I6I26_RS06915	COG1254	Belongs to the acylphosphatase family
I6I26_RS06925	COG1278	Cold shock
I6I26_RS06935	COG1131	(ABC) transporter
I6I26_RS06955	COG1473	amidohydrolase
I6I26_RS06965	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6I26_RS06970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I26_RS06975	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6I26_RS06980	COG0527	aspartate kinase activity
I6I26_RS06985	COG0488	(ABC) transporter
I6I26_RS06990	COG2996	Protein conserved in bacteria
I6I26_RS06995	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6I26_RS07000	COG0573	inorganic phosphate transmembrane transporter activity
I6I26_RS07005	COG0581	inorganic phosphate transmembrane transporter activity
I6I26_RS07010	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6I26_RS07015	COG0704	Plays a role in the regulation of phosphate uptake
I6I26_RS07020	COG1164	Oligoendopeptidase f
I6I26_RS07055	COG0561	phosphatase activity
I6I26_RS07060	COG2348	transferase activity, transferring amino-acyl groups
I6I26_RS07065	COG2348	transferase activity, transferring amino-acyl groups
I6I26_RS07080	COG0135	phosphoribosylanthranilate isomerase activity
I6I26_RS07085	COG0134	indole-3-glycerol-phosphate synthase activity
I6I26_RS07095	COG0512	Glutamine amidotransferase of anthranilate synthase
I6I26_RS07100	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6I26_RS07105	COG1363	Peptidase, m42
I6I26_RS07110	COG0287	Prephenate dehydrogenase
I6I26_RS07115	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I26_RS07120	COG1942	4-Oxalocrotonate Tautomerase
I6I26_RS07135	COG0392	lysyltransferase activity
I6I26_RS07135	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6I26_RS07140	COG0628	permease
I6I26_RS07145	COG3711	transcriptional antiterminator
I6I26_RS07150	COG1115	amino acid carrier protein
I6I26_RS07155	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6I26_RS07160	COG0187	DNA topoisomerase II activity
I6I26_RS07175	COG0824	Thioesterase
I6I26_RS07180	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6I26_RS07185	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I26_RS07190	COG1970	mechanosensitive ion channel activity
I6I26_RS07205	COG4846	Membrane protein involved in cytochrome C biogenesis
I6I26_RS07210	COG3763	UPF0154 protein
I6I26_RS07215	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6I26_RS07220	COG4224	UPF0291 protein
I6I26_RS07245	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6I26_RS07260	COG0833	amino acid
I6I26_RS07275	COG0083	homoserine kinase activity
I6I26_RS07280	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6I26_RS07285	COG0460	homoserine dehydrogenase
I6I26_RS07290	COG0527	aspartate kinase activity
I6I26_RS07305	COG1525	nuclease
I6I26_RS07370	COG0789	Transcriptional regulator
I6I26_RS07375	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I6I26_RS07380	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6I26_RS07385	COG0386	Belongs to the glutathione peroxidase family
I6I26_RS07390	COG1923	regulation of RNA biosynthetic process
I6I26_RS07395	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6I26_RS07400	COG2267	carboxylic ester hydrolase activity
I6I26_RS07405	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6I26_RS07415	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6I26_RS07420	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I6I26_RS07425	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6I26_RS07440	COG4550	Control of competence regulator ComK, YlbF/YmcA
I6I26_RS07445	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I26_RS07455	COG4195	phage-related replication protein
I6I26_RS07460	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6I26_RS07465	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6I26_RS07465	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6I26_RS07470	COG1692	metallophosphoesterase
I6I26_RS07480	COG1418	mRNA catabolic process
I6I26_RS07485	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6I26_RS07490	COG1546	Belongs to the CinA family
I6I26_RS07490	COG1058	Belongs to the CinA family
I6I26_RS07510	COG1028	Short-chain dehydrogenase reductase Sdr
I6I26_RS07515	COG0612	Peptidase, M16
I6I26_RS07520	COG0612	Peptidase, M16
I6I26_RS07525	COG2188	Transcriptional regulator
I6I26_RS07530	COG1674	ftsk spoiiie
I6I26_RS07540	COG1185	polyribonucleotide nucleotidyltransferase activity
I6I26_RS07545	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6I26_RS07550	COG0196	riboflavin kinase activity
I6I26_RS07560	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6I26_RS07565	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6I26_RS07570	COG1358	cellular component organization or biogenesis
I6I26_RS07575	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6I26_RS07580	COG0195	Participates in both transcription termination and antitermination
I6I26_RS07585	COG0779	Required for maturation of 30S ribosomal subunits
I6I26_RS07590	COG2176	DNA-directed DNA polymerase activity
I6I26_RS07595	COG0442	prolyl-tRNA aminoacylation
I6I26_RS07610	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6I26_RS07615	COG0233	cytoplasmic translational termination
I6I26_RS07620	COG0528	UMP kinase activity
I6I26_RS07625	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6I26_RS07630	COG0052	Belongs to the universal ribosomal protein uS2 family
I6I26_RS07650	COG4974	Belongs to the 'phage' integrase family
I6I26_RS07655	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I6I26_RS07660	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6I26_RS07665	COG0758	DNA mediated transformation
I6I26_RS07680	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6I26_RS07685	COG0045	succinate-CoA ligase (ADP-forming) activity
I6I26_RS07690	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6I26_RS07715	COG0336	Belongs to the RNA methyltransferase TrmD family
I6I26_RS07725	COG0228	four-way junction DNA binding
I6I26_RS07730	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6I26_RS07735	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I6I26_RS07740	COG0552	protein localization to endoplasmic reticulum
I6I26_RS07745	COG1196	nuclear chromosome segregation
I6I26_RS07750	COG0571	ribonuclease III activity
I6I26_RS07770	COG0416	fatty acid biosynthetic process
I6I26_RS07775	COG1349	DNA-binding transcription factor activity
I6I26_RS07780	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6I26_RS07785	COG1461	Dihydroxyacetone kinase
I6I26_RS07790	COG1302	Protein conserved in bacteria
I6I26_RS07795	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6I26_RS07800	COG1564	THIamine pyrophosphokinase
I6I26_RS07805	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6I26_RS07810	COG1162	GTPase activity
I6I26_RS07820	COG0631	protein serine/threonine phosphatase activity
I6I26_RS07825	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6I26_RS07830	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6I26_RS07830	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I26_RS07835	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I26_RS07850	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6I26_RS07855	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6I26_RS07860	COG1758	RNA polymerase activity
I6I26_RS07865	COG0194	GDP metabolic process
I6I26_RS07885	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6I26_RS07890	COG0284	orotidine-5'-phosphate decarboxylase activity
I6I26_RS07895	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6I26_RS07900	COG0505	Belongs to the CarA family
I6I26_RS07905	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6I26_RS07910	COG0540	Belongs to the ATCase OTCase family
I6I26_RS07920	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I6I26_RS07925	COG0564	pseudouridine synthase activity
I6I26_RS07930	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6I26_RS07935	COG3942	CHAP domain
I6I26_RS07935	COG1388	LysM domain
I6I26_RS07945	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6I26_RS07950	COG3599	regulation of cell shape
I6I26_RS07960	COG0762	integral membrane protein
I6I26_RS07965	COG1799	cell septum assembly
I6I26_RS07970	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6I26_RS07975	COG1496	oxidoreductase activity
I6I26_RS07980	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6I26_RS07985	COG0849	cell division
I6I26_RS07990	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6I26_RS08000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I26_RS08005	COG0768	penicillin binding
I6I26_RS08010	COG4839	cell division protein FtsL
I6I26_RS08015	COG0275	rRNA processing
I6I26_RS08025	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
I6I26_RS08035	COG1011	Hydrolase
I6I26_RS08065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I26_RS08080	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6I26_RS08085	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6I26_RS08090	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6I26_RS08095	COG1053	succinate dehydrogenase
I6I26_RS08100	COG2009	succinate dehydrogenase
I6I26_RS08105	COG0322	excinuclease ABC activity
I6I26_RS08110	COG3118	belongs to the thioredoxin family
I6I26_RS08115	COG1193	negative regulation of DNA recombination
I6I26_RS08120	COG1796	DNA polymerase
I6I26_RS08120	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6I26_RS08130	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
I6I26_RS08135	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6I26_RS08140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I26_RS08140	COG0072	phenylalanine-tRNA ligase activity
I6I26_RS08145	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6I26_RS08150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I26_RS08160	COG4509	Sortase family
I6I26_RS08195	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6I26_RS08210	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6I26_RS08215	COG0742	ribosomal rna small subunit methyltransferase
I6I26_RS08230	COG0584	glycerophosphoryl diester phosphodiesterase
I6I26_RS08240	COG0107	imidazoleglycerol-phosphate synthase activity
I6I26_RS08245	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6I26_RS08250	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6I26_RS08255	COG0131	Imidazoleglycerol-phosphate dehydratase
I6I26_RS08260	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6I26_RS08270	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I6I26_RS08275	COG3679	Belongs to the UPF0342 family
I6I26_RS08290	COG0109	protoheme IX farnesyltransferase activity
I6I26_RS08295	COG1612	heme a metabolic process
I6I26_RS08305	COG0772	Belongs to the SEDS family
I6I26_RS08310	COG4838	Belongs to the UPF0358 family
I6I26_RS08315	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6I26_RS08325	COG1217	gtp-binding protein TYPA
I6I26_RS08335	COG0483	inositol monophosphate 1-phosphatase activity
I6I26_RS08340	COG4493	Belongs to the UPF0637 family
I6I26_RS08365	COG1177	transmembrane transport
I6I26_RS08370	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I26_RS08385	COG4476	Belongs to the UPF0223 family
I6I26_RS08395	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I26_RS08400	COG0022	dehydrogenase e1 component
I6I26_RS08415	COG0242	peptide deformylase activity
I6I26_RS08420	COG5503	Protein of unknown function (DUF1447)
I6I26_RS08430	COG0569	domain protein
I6I26_RS08435	COG1294	oxidase, subunit
I6I26_RS08440	COG1271	oxidase subunit
I6I26_RS08450	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I26_RS08455	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I26_RS08465	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6I26_RS08485	COG1122	ATPase activity
I6I26_RS08490	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6I26_RS08500	COG0151	Belongs to the GarS family
I6I26_RS08505	COG0138	bifunctional purine biosynthesis protein purh
I6I26_RS08515	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6I26_RS08525	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I26_RS08530	COG0047	phosphoribosylformylglycinamidine synthase activity
I6I26_RS08535	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I26_RS08540	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6I26_RS08545	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6I26_RS08550	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6I26_RS08555	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6I26_RS08560	COG1017	nitric oxide dioxygenase activity
I6I26_RS08560	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6I26_RS08570	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6I26_RS08585	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6I26_RS08600	COG1316	TRANSCRIPTIONal
I6I26_RS08625	COG3594	Acyltransferase
I6I26_RS08630	COG0436	Aminotransferase
I6I26_RS08635	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6I26_RS08645	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6I26_RS08650	COG1169	isochorismate synthase
I6I26_RS08655	COG1575	Belongs to the MenA family. Type 1 subfamily
I6I26_RS08665	COG2314	TM2 domain
I6I26_RS08670	COG2808	Putative FMN-binding domain
I6I26_RS08675	COG0456	acetyltransferase
I6I26_RS08680	COG1846	Transcriptional regulator
I6I26_RS08715	COG4873	Protein conserved in bacteria
I6I26_RS08725	COG0737	Belongs to the 5'-nucleotidase family
I6I26_RS08730	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I26_RS08735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I26_RS08735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I26_RS08740	COG0861	Integral membrane protein TerC family
I6I26_RS08745	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6I26_RS08755	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I26_RS08760	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I26_RS08765	COG2814	Major facilitator Superfamily
I6I26_RS08770	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6I26_RS08775	COG2382	esterase
I6I26_RS08780	COG1115	amino acid carrier protein
I6I26_RS08785	COG0628	permease
I6I26_RS08795	COG0475	glutathione-regulated potassium exporter activity
I6I26_RS08795	COG0569	domain protein
I6I26_RS08800	COG2239	Acts as a magnesium transporter
I6I26_RS08805	COG0564	pseudouridine synthase activity
I6I26_RS08810	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6I26_RS08815	COG2357	RelA SpoT domain protein
I6I26_RS08830	COG2346	COG2346, Truncated hemoglobins
I6I26_RS08840	COG1164	Oligoendopeptidase f
I6I26_RS08850	COG4862	establishment of competence for transformation
I6I26_RS08855	COG1393	Belongs to the ArsC family
I6I26_RS08860	COG0180	Tryptophanyl-tRNA synthetase
I6I26_RS08870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I26_RS08875	COG0601	transmembrane transport
I6I26_RS08880	COG4608	Belongs to the ABC transporter superfamily
I6I26_RS08885	COG0444	Belongs to the ABC transporter superfamily
I6I26_RS08905	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I26_RS08915	COG1881	PFAM PEBP family protein
I6I26_RS08920	COG0542	response to heat
I6I26_RS08935	COG0561	phosphatase activity
I6I26_RS08955	COG1074	ATP-dependent DNA helicase activity
I6I26_RS08975	COG0398	Pfam SNARE associated Golgi protein
I6I26_RS08985	COG0137	argininosuccinate synthase activity
I6I26_RS08990	COG0165	Argininosuccinate lyase
I6I26_RS08995	COG0584	glycerophosphoryl diester phosphodiesterase
I6I26_RS09000	COG0584	glycerophosphoryl diester phosphodiesterase
I6I26_RS09020	COG1902	pentaerythritol trinitrate reductase activity
I6I26_RS09025	COG1098	S1 RNA binding domain
I6I26_RS09040	COG2111	Na H antiporter
I6I26_RS09040	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I26_RS09045	COG2111	Na H antiporter
I6I26_RS09055	COG0651	ATP synthesis coupled electron transport
I6I26_RS09065	COG2212	antiporter activity
I6I26_RS09085	COG2050	protein possibly involved in aromatic compounds catabolism
I6I26_RS09090	COG2056	Na+-H+ antiporter family
I6I26_RS09095	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6I26_RS09105	COG0316	Belongs to the HesB IscA family
I6I26_RS09110	COG4844	belongs to the
I6I26_RS09115	COG1252	NADH dehydrogenase
I6I26_RS09120	COG4837	Protein of unknown function (DUF1462)
I6I26_RS09125	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6I26_RS09130	COG0583	DNA-binding transcription factor activity
I6I26_RS09140	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I6I26_RS09150	COG1696	Membrane protein involved in D-alanine export
I6I26_RS09155	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I26_RS09175	COG2445	Protein of unknown function DUF86
I6I26_RS09185	COG4470	Protein conserved in bacteria
I6I26_RS09190	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I26_RS09195	COG0737	Belongs to the 5'-nucleotidase family
I6I26_RS09200	COG0730	response to heat
I6I26_RS09205	COG1801	Protein of unknown function DUF72
I6I26_RS09210	COG2070	2-Nitropropane dioxygenase
I6I26_RS09215	COG1253	flavin adenine dinucleotide binding
I6I26_RS09220	COG0719	Fe-S assembly protein
I6I26_RS09225	COG0822	iron-sulfur transferase activity
I6I26_RS09230	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6I26_RS09235	COG0719	Fe-S assembly protein
I6I26_RS09240	COG0396	ATPase activity
I6I26_RS09250	COG3237	CsbD-like
I6I26_RS09260	COG1464	Belongs to the NlpA lipoprotein family
I6I26_RS09265	COG2011	ABC-type metal ion transport system permease component
I6I26_RS09270	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I26_RS09280	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I6I26_RS09285	COG0509	glycine decarboxylation via glycine cleavage system
I6I26_RS09290	COG1393	Belongs to the ArsC family
I6I26_RS09295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I26_RS09305	COG0710	3-dehydroquinate dehydratase activity
I6I26_RS09310	COG1764	response to oxidative stress
I6I26_RS09320	COG0406	alpha-ribazole phosphatase activity
I6I26_RS09350	COG4195	phage-related replication protein
I6I26_RS09375	COG1278	Cold shock
I6I26_RS09385	COG0477	Major facilitator Superfamily
I6I26_RS09390	COG3433	isochorismatase activity
I6I26_RS09390	COG1535	isochorismatase
I6I26_RS09420	COG0346	lactoylglutathione lyase activity
I6I26_RS09465	COG0557	exoribonuclease II activity
I6I26_RS09470	COG1647	Serine aminopeptidase, S33
I6I26_RS09475	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6I26_RS09485	COG0148	phosphopyruvate hydratase activity
I6I26_RS09490	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6I26_RS09495	COG0149	triose-phosphate isomerase activity
I6I26_RS09500	COG0126	phosphoglycerate kinase activity
I6I26_RS09535	COG0740	serine-type endopeptidase activity
I6I26_RS09550	COG1388	LysM domain
I6I26_RS09550	COG5632	N-Acetylmuramoyl-L-alanine amidase
I6I26_RS09640	COG0740	serine-type endopeptidase activity
I6I26_RS09725	COG2226	methyltransferase
I6I26_RS09775	COG1484	DNA-dependent DNA replication
I6I26_RS09845	COG1396	sequence-specific DNA binding
I6I26_RS09875	COG1481	regulation of sporulation
I6I26_RS09880	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6I26_RS09885	COG1660	Displays ATPase and GTPase activities
I6I26_RS09890	COG0492	ferredoxin-NADP+ reductase activity
I6I26_RS09900	COG0110	maltose O-acetyltransferase activity
I6I26_RS09905	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6I26_RS09915	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6I26_RS09920	COG0556	nucleotide-excision repair
I6I26_RS09935	COG3942	CHAP domain
I6I26_RS09935	COG1388	LysM domain
I6I26_RS09945	COG0653	protein targeting
I6I26_RS09950	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6I26_RS09955	COG1040	competence protein
I6I26_RS09960	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I6I26_RS09970	COG1739	Uncharacterized protein family UPF0029
I6I26_RS09975	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I26_RS09995	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6I26_RS10000	COG1929	Belongs to the glycerate kinase type-1 family
I6I26_RS10020	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6I26_RS10035	COG4604	ABC transporter, ATP-binding protein
I6I26_RS10040	COG4605	iron ion homeostasis
I6I26_RS10045	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I26_RS10050	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I26_RS10055	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I26_RS10060	COG1780	Probably involved in ribonucleotide reductase function
I6I26_RS10075	COG3104	oligopeptide transport
I6I26_RS10080	COG1597	lipid kinase activity
I6I26_RS10090	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I26_RS10095	COG1174	glycine betaine transport
I6I26_RS10100	COG1125	glycine betaine transport
I6I26_RS10100	COG0517	IMP dehydrogenase activity
I6I26_RS10105	COG0514	ATP-dependent DNA helicase (RecQ)
I6I26_RS10110	COG0488	(ABC) transporter
I6I26_RS10120	COG1368	sulfuric ester hydrolase activity
I6I26_RS10150	COG0512	Glutamine amidotransferase of anthranilate synthase
I6I26_RS10150	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I26_RS10155	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6I26_RS10160	COG0720	synthase
I6I26_RS10165	COG0602	queuosine metabolic process
I6I26_RS10175	COG0463	Glycosyl transferase, family 2
I6I26_RS10180	COG0656	L-ascorbic acid biosynthetic process
I6I26_RS10185	COG1253	flavin adenine dinucleotide binding
I6I26_RS10190	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6I26_RS10195	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I26_RS10195	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I26_RS10195	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I26_RS10200	COG1105	Belongs to the carbohydrate kinase PfkB family
I6I26_RS10205	COG1349	DNA-binding transcription factor activity
I6I26_RS10210	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6I26_RS10230	COG0415	Belongs to the DNA photolyase family
I6I26_RS10235	COG0471	metal ion transport
I6I26_RS10240	COG0039	L-malate dehydrogenase activity
I6I26_RS10250	COG4989	oxidoreductase activity
I6I26_RS10255	COG0523	cobalamin synthesis protein
I6I26_RS10265	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6I26_RS10270	COG4988	ABC transporter
I6I26_RS10275	COG1968	undecaprenyl-diphosphatase activity
I6I26_RS10290	COG1611	Belongs to the LOG family
I6I26_RS10295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I26_RS10320	COG2839	Protein conserved in bacteria
I6I26_RS10325	COG2814	Major facilitator Superfamily
I6I26_RS10330	COG0583	DNA-binding transcription factor activity
I6I26_RS10345	COG0217	transcriptional regulatory protein
I6I26_RS10355	COG2169	Transcriptional regulator
I6I26_RS10365	COG3942	CHAP domain
I6I26_RS10365	COG1388	LysM domain
I6I26_RS10370	COG0306	phosphate transporter
I6I26_RS10375	COG1392	Phosphate transport regulator
I6I26_RS10385	COG0577	efflux transmembrane transporter activity
I6I26_RS10390	COG1136	(ABC) transporter
I6I26_RS10395	COG2205	protein histidine kinase activity
I6I26_RS10400	COG0745	RESPONSE REGULATOR receiver
I6I26_RS10405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I26_RS10415	COG0657	acetylesterase activity
I6I26_RS10420	COG3949	Membrane
I6I26_RS10430	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I6I26_RS10435	COG1461	Dihydroxyacetone kinase
I6I26_RS10440	COG2376	Dihydroxyacetone kinase
I6I26_RS10445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I26_RS10450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I26_RS10455	COG1120	ATPase activity
I6I26_RS10460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I6I26_RS10465	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6I26_RS10470	COG1132	(ABC) transporter
I6I26_RS10475	COG1686	Belongs to the peptidase S11 family
I6I26_RS10480	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6I26_RS10490	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6I26_RS10495	COG1682	transport, permease protein
I6I26_RS10500	COG1134	teichoic acid transport
I6I26_RS10505	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I6I26_RS10520	COG1121	(ABC) transporter
I6I26_RS10525	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I26_RS10530	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6I26_RS10540	COG1320	monovalent cation:proton antiporter activity
I6I26_RS10550	COG1863	multisubunit Na H antiporter MnhE subunit
I6I26_RS10555	COG0651	ATP synthesis coupled electron transport
I6I26_RS10560	COG1006	Multisubunit Na H antiporter MnhC subunit
I6I26_RS10565	COG2111	Na H antiporter
I6I26_RS10570	COG2111	Na H antiporter
I6I26_RS10570	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I26_RS10605	COG2267	carboxylic ester hydrolase activity
I6I26_RS10620	COG2267	carboxylic ester hydrolase activity
I6I26_RS10625	COG0546	phosphoglycolate phosphatase activity
I6I26_RS10630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I26_RS10635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I26_RS10640	COG0534	Mate efflux family protein
I6I26_RS10655	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6I26_RS10660	COG0018	arginyl-trna synthetase
I6I26_RS10680	COG3875	lactate racemase activity
I6I26_RS10685	COG1606	tRNA processing
I6I26_RS10690	COG1691	(AIR) carboxylase
I6I26_RS10695	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
I6I26_RS10705	COG1078	dGTPase activity
I6I26_RS10710	COG0519	Catalyzes the synthesis of GMP from XMP
I6I26_RS10715	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6I26_RS10720	COG0667	Aldo Keto reductase
I6I26_RS10735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I26_RS10740	COG4844	belongs to the
I6I26_RS10755	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6I26_RS10760	COG0095	Lipoate-protein ligase
I6I26_RS10765	COG0280	phosphate acetyltransferase
I6I26_RS10770	COG3253	May function as heme-dependent peroxidase
I6I26_RS10775	COG2966	Psort location CytoplasmicMembrane, score
I6I26_RS10790	COG2363	Small membrane protein
I6I26_RS10805	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I6I26_RS10820	COG0477	Major facilitator Superfamily
I6I26_RS10835	COG0183	Belongs to the thiolase family
I6I26_RS10840	COG0318	PFAM AMP-dependent synthetase and ligase
I6I26_RS10855	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I6I26_RS10870	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6I26_RS10875	COG1469	GTP cyclohydrolase I activity
I6I26_RS10910	COG0431	NADPH-dependent FMN reductase
I6I26_RS10915	COG0561	phosphatase activity
I6I26_RS10925	COG1428	Deoxynucleoside kinase
I6I26_RS10930	COG1428	Deoxynucleoside kinase
I6I26_RS10935	COG0546	phosphoglycolate phosphatase activity
I6I26_RS10940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I26_RS10960	COG1063	alcohol dehydrogenase
I6I26_RS10965	COG2814	Major facilitator Superfamily
I6I26_RS10970	COG1349	DNA-binding transcription factor activity
I6I26_RS10990	COG1473	amidohydrolase
I6I26_RS10995	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I26_RS11000	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6I26_RS11005	COG0049	tRNA binding
I6I26_RS11010	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6I26_RS11020	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6I26_RS11025	COG0085	RNA polymerase activity
I6I26_RS11030	COG2813	Specifically methylates the guanine in position
I6I26_RS11040	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6I26_RS11045	COG0081	regulation of translation
I6I26_RS11050	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6I26_RS11055	COG0250	Participates in transcription elongation, termination and antitermination
I6I26_RS11065	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6I26_RS11075	COG3688	RNA-binding protein containing a PIN domain
I6I26_RS11085	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I6I26_RS11090	COG0215	cysteine-tRNA ligase activity
I6I26_RS11100	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I26_RS11105	COG4956	integral membrane protein (PIN domain superfamily)
I6I26_RS11110	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6I26_RS11115	COG0542	response to heat
I6I26_RS11120	COG3869	Catalyzes the specific phosphorylation of arginine residues in
I6I26_RS11125	COG3880	PFAM UvrB UvrC protein
I6I26_RS11135	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6I26_RS11140	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I6I26_RS11145	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I6I26_RS11150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I26_RS11230	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6I26_RS11235	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6I26_RS11240	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6I26_RS11250	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I26_RS11260	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I26_RS11275	COG1098	S1 RNA binding domain
I6I26_RS11285	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6I26_RS11290	COG3956	TIGRFAM MazG family protein
I6I26_RS11295	COG2244	polysaccharide biosynthetic process
I6I26_RS11300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6I26_RS11305	COG0193	aminoacyl-tRNA hydrolase activity
I6I26_RS11310	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6I26_RS11315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6I26_RS11320	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I26_RS11325	COG2088	sporulation resulting in formation of a cellular spore
I6I26_RS11330	COG0251	oxidation-reduction process
I6I26_RS11335	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I26_RS11340	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6I26_RS11345	COG4466	Protein conserved in bacteria
I6I26_RS11350	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6I26_RS11355	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I6I26_RS11360	COG0084	hydrolase, TatD family'
I6I26_RS11365	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I26_RS11365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I26_RS11370	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6I26_RS11375	COG2827	Endonuclease containing a URI domain
I6I26_RS11380	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6I26_RS11385	COG4467	Involved in initiation control of chromosome replication
I6I26_RS11390	COG1774	PSP1 C-terminal conserved region
I6I26_RS11395	COG0470	DNA polymerase III
I6I26_RS11400	COG3870	Protein conserved in bacteria
I6I26_RS11410	COG1982	Orn Lys Arg decarboxylase major
I6I26_RS11415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I26_RS11435	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I6I26_RS11445	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6I26_RS11460	COG2188	Transcriptional regulator
I6I26_RS11465	COG0366	Alpha amylase catalytic
I6I26_RS11470	COG1263	PTS System
I6I26_RS11470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I26_RS11480	COG0493	'glutamate synthase
I6I26_RS11485	COG0070	glutamate synthase
I6I26_RS11485	COG0067	glutamate synthase
I6I26_RS11485	COG0069	glutamate synthase activity
I6I26_RS11490	COG0583	DNA-binding transcription factor activity
I6I26_RS11520	COG0438	transferase activity, transferring glycosyl groups
I6I26_RS11535	COG2011	ABC-type metal ion transport system permease component
I6I26_RS11540	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I26_RS11545	COG1278	Cold shock
I6I26_RS11550	COG3759	membrane
I6I26_RS11575	COG0626	cystathionine gamma-synthase activity
I6I26_RS11580	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I26_RS11595	COG1279	arginine transmembrane transporter activity
I6I26_RS11600	COG0733	neurotransmitter:sodium symporter activity
I6I26_RS11610	COG1647	Serine aminopeptidase, S33
I6I26_RS11625	COG5609	conserved protein (DUF2294)
I6I26_RS11630	COG3002	Belongs to the UPF0753 family
I6I26_RS11635	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I26_RS11645	COG0523	cobalamin synthesis protein
I6I26_RS11650	COG0519	Catalyzes the synthesis of GMP from XMP
I6I26_RS11650	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I26_RS11655	COG0517	IMP dehydrogenase activity
I6I26_RS11655	COG0516	GMP reductase activity
I6I26_RS11660	COG2233	PERMEase
I6I26_RS11665	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I26_RS11680	COG5183	chlorophyll binding
I6I26_RS11690	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6I26_RS11695	COG1063	alcohol dehydrogenase
I6I26_RS11705	COG1823	symporter activity
I6I26_RS11715	COG0450	alkyl hydroperoxide reductase
I6I26_RS11720	COG3634	alkyl hydroperoxide reductase activity
I6I26_RS11745	COG1280	lysine exporter protein (LysE YggA)
I6I26_RS11780	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6I26_RS11790	COG0360	Binds together with S18 to 16S ribosomal RNA
I6I26_RS11805	COG0012	GTP binding
I6I26_RS11810	COG4481	Protein conserved in bacteria
I6I26_RS11815	COG0668	transmembrane transport
I6I26_RS11820	COG1475	DNA binding
I6I26_RS11825	COG0626	cystathionine gamma-synthase activity
I6I26_RS11830	COG0626	cystathionine gamma-synthase activity
I6I26_RS11835	COG0646	methionine synthase
I6I26_RS11835	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6I26_RS11840	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6I26_RS11865	COG3942	CHAP domain
I6I26_RS11915	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6I26_RS11930	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6I26_RS11935	COG2814	Major facilitator Superfamily
I6I26_RS11965	COG0183	Belongs to the thiolase family
I6I26_RS11970	COG3250	beta-galactosidase activity
I6I26_RS11975	COG1028	Short-chain dehydrogenase reductase Sdr
I6I26_RS11980	COG1312	Catalyzes the dehydration of D-mannonate
I6I26_RS11985	COG1904	glucuronate isomerase
I6I26_RS11990	COG2211	Major facilitator Superfamily
I6I26_RS12000	COG0800	Aldolase
I6I26_RS12005	COG2207	Transcriptional regulator
I6I26_RS12030	COG1476	TRANSCRIPTIONal
I6I26_RS12040	COG1131	(ABC) transporter
I6I26_RS12050	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I26_RS12065	COG1136	(ABC) transporter
I6I26_RS12070	COG0577	efflux transmembrane transporter activity
I6I26_RS12085	COG0300	oxidoreductase activity
I6I26_RS12100	COG0577	efflux transmembrane transporter activity
I6I26_RS12105	COG1136	(ABC) transporter
I6I26_RS12125	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX