locus-tag	class	description
I6I31_RS00010	COG0210	DNA helicase
I6I31_RS00015	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
I6I31_RS00020	COG4496	protein, YerC YecD
I6I31_RS00025	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6I31_RS00035	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
I6I31_RS00040	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6I31_RS00045	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6I31_RS00055	COG0077	Prephenate dehydratase
I6I31_RS00065	COG1335	isochorismatase
I6I31_RS00070	COG1227	inorganic diphosphatase activity
I6I31_RS00080	COG2706	6-phosphogluconolactonase activity
I6I31_RS00125	COG1131	(ABC) transporter
I6I31_RS00140	COG1725	Transcriptional regulator
I6I31_RS00195	COG0459	protein refolding
I6I31_RS00200	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6I31_RS00235	COG3290	protein histidine kinase activity
I6I31_RS00240	COG3279	Response regulator of the LytR AlgR family
I6I31_RS00245	COG1621	beta-fructofuranosidase activity
I6I31_RS00275	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I6I31_RS00280	COG0488	(ABC) transporter
I6I31_RS00285	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6I31_RS00290	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6I31_RS00295	COG0456	acetyltransferase
I6I31_RS00300	COG1214	PFAM Peptidase M22, glycoprotease
I6I31_RS00305	COG0802	atpase or kinase
I6I31_RS00345	COG0066	3-isopropylmalate dehydratase activity
I6I31_RS00380	COG3091	SprT-like family
I6I31_RS00385	COG2183	response to ionizing radiation
I6I31_RS00390	COG1191	sigma factor activity
I6I31_RS00405	COG2208	phosphoserine phosphatase activity
I6I31_RS00410	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6I31_RS00420	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I31_RS00425	COG0736	holo-[acyl-carrier-protein] synthase activity
I6I31_RS00445	COG0513	Belongs to the DEAD box helicase family
I6I31_RS00450	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6I31_RS00455	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I31_RS00465	COG0772	Belongs to the SEDS family
I6I31_RS00475	COG1937	Protein conserved in bacteria
I6I31_RS00480	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6I31_RS00490	COG0706	membrane insertase activity
I6I31_RS00495	COG0352	thiamine-phosphate diphosphorylase activity
I6I31_RS00500	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I6I31_RS00510	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6I31_RS00515	COG1388	LysM domain
I6I31_RS00520	COG0629	single-stranded DNA binding
I6I31_RS00530	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I6I31_RS00535	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6I31_RS00545	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6I31_RS00550	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6I31_RS00555	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6I31_RS00560	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6I31_RS00565	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6I31_RS00570	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6I31_RS00580	COG0356	it plays a direct role in the translocation of protons across the membrane
I6I31_RS00590	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6I31_RS00595	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6I31_RS00600	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6I31_RS00610	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I31_RS00615	COG0009	L-threonylcarbamoyladenylate synthase
I6I31_RS00620	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I31_RS00630	COG1435	thymidine kinase activity
I6I31_RS00635	COG0254	rRNA binding
I6I31_RS00640	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6I31_RS00645	COG1012	belongs to the aldehyde dehydrogenase family
I6I31_RS00655	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6I31_RS00660	COG0191	fructose-bisphosphate aldolase activity
I6I31_RS00670	COG0504	CTP synthase activity
I6I31_RS00675	COG3343	RNA polymerase activity
I6I31_RS00685	COG5146	pantothenate kinase activity
I6I31_RS00705	COG1854	S-ribosylhomocysteine lyase activity
I6I31_RS00715	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6I31_RS00720	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I6I31_RS00725	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6I31_RS00730	COG0813	purine-nucleoside phosphorylase activity
I6I31_RS00755	COG1482	cell wall glycoprotein biosynthetic process
I6I31_RS00760	COG0702	epimerase
I6I31_RS00765	COG0640	Transcriptional regulator
I6I31_RS00785	COG0561	phosphatase activity
I6I31_RS00790	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6I31_RS00795	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I31_RS00805	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I6I31_RS00855	COG0489	protein tyrosine kinase activity
I6I31_RS00860	COG2814	Major facilitator Superfamily
I6I31_RS00880	COG4284	Utp--glucose-1-phosphate uridylyltransferase
I6I31_RS00885	COG1988	membrane-bound metal-dependent
I6I31_RS00895	COG2329	Antibiotic biosynthesis monooxygenase
I6I31_RS00900	COG3314	Sporulation integral membrane protein YlbJ
I6I31_RS00905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I31_RS00910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I31_RS00915	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I6I31_RS00920	COG3457	Alanine racemase
I6I31_RS00925	COG4264	IucA IucC family
I6I31_RS00930	COG2814	Major facilitator Superfamily
I6I31_RS00935	COG4264	IucA IucC family
I6I31_RS00940	COG1302	Protein conserved in bacteria
I6I31_RS00960	COG2130	NADP-dependent
I6I31_RS00995	COG0698	ribose 5-phosphate isomerase
I6I31_RS01000	COG0698	ribose 5-phosphate isomerase
I6I31_RS01010	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6I31_RS01015	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6I31_RS01020	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I6I31_RS01025	COG0101	tRNA pseudouridine synthase activity
I6I31_RS01035	COG1122	ATPase activity
I6I31_RS01040	COG1122	ATPase activity
I6I31_RS01045	COG0203	ribosomal protein L17
I6I31_RS01050	COG0202	RNA polymerase activity
I6I31_RS01060	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6I31_RS01065	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I31_RS01070	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I6I31_RS01075	COG0563	adenylate kinase activity
I6I31_RS01080	COG0201	protein transport
I6I31_RS01085	COG0200	Binds to the 23S rRNA
I6I31_RS01090	COG1841	ribosomal large subunit assembly
I6I31_RS01095	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6I31_RS01100	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6I31_RS01105	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6I31_RS01110	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I6I31_RS01115	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6I31_RS01120	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6I31_RS01125	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6I31_RS01130	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6I31_RS01135	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6I31_RS01145	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6I31_RS01150	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6I31_RS01155	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6I31_RS01160	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6I31_RS01165	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6I31_RS01170	COG0089	rRNA binding
I6I31_RS01175	COG0088	Forms part of the polypeptide exit tunnel
I6I31_RS01180	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6I31_RS01195	COG2252	PERMEase
I6I31_RS01200	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6I31_RS01200	COG0551	DNA topoisomerase type I activity
I6I31_RS01235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6I31_RS01240	COG2348	transferase activity, transferring amino-acyl groups
I6I31_RS01265	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6I31_RS01270	COG0746	molybdenum cofactor guanylyltransferase activity
I6I31_RS01280	COG0314	molybdopterin synthase activity
I6I31_RS01285	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6I31_RS01290	COG0303	'Molybdopterin
I6I31_RS01295	COG0315	cyclic pyranopterin monophosphate synthase activity
I6I31_RS01300	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6I31_RS01305	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6I31_RS01310	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I6I31_RS01315	COG4149	molybdate abc transporter
I6I31_RS01320	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6I31_RS01325	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6I31_RS01335	COG1268	BioY protein
I6I31_RS01350	COG4413	Urea transporter
I6I31_RS01355	COG0831	urea catabolic process
I6I31_RS01360	COG0832	Belongs to the urease beta subunit family
I6I31_RS01365	COG0804	urea catabolic process
I6I31_RS01370	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
I6I31_RS01375	COG0830	nickel cation binding
I6I31_RS01380	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6I31_RS01385	COG0829	nickel cation binding
I6I31_RS01410	COG3942	CHAP domain
I6I31_RS01415	COG1757	Na H antiporter
I6I31_RS01430	COG3942	CHAP domain
I6I31_RS01435	COG2076	Multidrug Resistance protein
I6I31_RS01445	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I31_RS01475	COG2378	regulation of single-species biofilm formation
I6I31_RS01495	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I6I31_RS01500	COG1263	PTS System
I6I31_RS01500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I31_RS01555	COG1028	Short-chain dehydrogenase reductase Sdr
I6I31_RS01580	COG0010	Belongs to the arginase family
I6I31_RS01585	COG1266	CAAX protease self-immunity
I6I31_RS01590	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I6I31_RS01595	COG2258	MOSC domain
I6I31_RS01600	COG2017	converts alpha-aldose to the beta-anomer
I6I31_RS01620	COG3152	Membrane
I6I31_RS01625	COG2094	Belongs to the DNA glycosylase MPG family
I6I31_RS01655	COG1304	FMN binding
I6I31_RS01660	COG0598	Magnesium transport protein CorA
I6I31_RS01685	COG2814	Major facilitator Superfamily
I6I31_RS01690	COG1566	PFAM secretion protein HlyD family protein
I6I31_RS01710	COG2814	Major facilitator Superfamily
I6I31_RS01715	COG4640	response to antibiotic
I6I31_RS01730	COG1136	(ABC) transporter
I6I31_RS01735	COG0577	efflux transmembrane transporter activity
I6I31_RS01740	COG0745	RESPONSE REGULATOR receiver
I6I31_RS01745	COG3850	Histidine kinase
I6I31_RS01745	COG5002	protein histidine kinase activity
I6I31_RS01760	COG1620	l-lactate permease
I6I31_RS01765	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6I31_RS01775	COG0463	Glycosyl transferase, family 2
I6I31_RS01775	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6I31_RS01780	COG0456	acetyltransferase
I6I31_RS01785	COG0604	alcohol dehydrogenase
I6I31_RS01860	COG0778	Nitroreductase
I6I31_RS01865	COG1846	Transcriptional regulator
I6I31_RS01875	COG2223	nitrite transmembrane transporter activity
I6I31_RS01880	COG2197	response regulator
I6I31_RS01885	COG4585	Histidine kinase
I6I31_RS01895	COG2181	nitrate reductase activity
I6I31_RS01905	COG1140	nitrate reductase beta subunit
I6I31_RS01910	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6I31_RS01920	COG2146	nitrite reductase [NAD(P)H] activity
I6I31_RS01925	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I31_RS01940	COG0747	negative chemotaxis
I6I31_RS01970	COG2348	transferase activity, transferring amino-acyl groups
I6I31_RS01980	COG1126	abc transporter atp-binding protein
I6I31_RS01985	COG0765	amino acid transport
I6I31_RS01990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I31_RS02005	COG0588	phosphoglycerate mutase activity
I6I31_RS02010	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6I31_RS02035	COG2814	Major facilitator Superfamily
I6I31_RS02060	COG0531	amino acid
I6I31_RS02070	COG0706	membrane insertase activity
I6I31_RS02105	COG1346	cytolysis
I6I31_RS02110	COG1174	glycine betaine transport
I6I31_RS02120	COG1174	glycine betaine transport
I6I31_RS02135	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
I6I31_RS02140	COG0531	amino acid
I6I31_RS02155	COG0390	transport system, permease component
I6I31_RS02160	COG4619	ABC transporter
I6I31_RS02175	COG4808	Protein conserved in bacteria
I6I31_RS02185	COG1028	Short-chain dehydrogenase reductase Sdr
I6I31_RS02195	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6I31_RS02200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I31_RS02205	COG4221	oxidoreductase activity
I6I31_RS02225	COG0494	nUDIX hydrolase
I6I31_RS02240	COG2610	gluconate transmembrane transporter activity
I6I31_RS02250	COG1802	Transcriptional regulator
I6I31_RS02265	COG0671	phosphoesterase, PA-phosphatase related
I6I31_RS02270	COG2357	RelA SpoT domain protein
I6I31_RS02275	COG4876	unkown
I6I31_RS02320	COG0586	Pfam SNARE associated Golgi protein
I6I31_RS02325	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
I6I31_RS02335	COG3949	Membrane
I6I31_RS02340	COG1012	belongs to the aldehyde dehydrogenase family
I6I31_RS02355	COG1012	belongs to the aldehyde dehydrogenase family
I6I31_RS02360	COG0778	Nitroreductase
I6I31_RS02375	COG3764	Sortase (surface protein transpeptidase)
I6I31_RS02390	COG1760	l-serine dehydratase
I6I31_RS02395	COG1760	l-serine dehydratase
I6I31_RS02425	COG1869	D-ribose catabolic process
I6I31_RS02430	COG4975	Glucose uptake
I6I31_RS02445	COG2843	Capsule synthesis protein
I6I31_RS02455	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6I31_RS02475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I31_RS02480	COG1063	alcohol dehydrogenase
I6I31_RS02485	COG1266	CAAX protease self-immunity
I6I31_RS02490	COG1263	PTS System
I6I31_RS02490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I31_RS02490	COG2190	(PTS) system
I6I31_RS02495	COG0028	Belongs to the TPP enzyme family
I6I31_RS02500	COG1346	cytolysis
I6I31_RS02505	COG1380	Effector of murein hydrolase LrgA
I6I31_RS02510	COG0583	DNA-binding transcription factor activity
I6I31_RS02530	COG3425	synthase
I6I31_RS02535	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6I31_RS02585	COG2608	mercury ion transmembrane transporter activity
I6I31_RS02625	COG1388	LysM domain
I6I31_RS02640	COG1113	amino acid transport
I6I31_RS02650	COG3001	Fructosamine kinase
I6I31_RS02655	COG0167	dihydroorotate dehydrogenase activity
I6I31_RS02665	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6I31_RS02700	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I6I31_RS02705	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6I31_RS02710	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6I31_RS02720	COG3527	Alpha-acetolactate decarboxylase
I6I31_RS02725	COG0028	Belongs to the TPP enzyme family
I6I31_RS02730	COG0039	L-malate dehydrogenase activity
I6I31_RS02735	COG0583	DNA-binding transcription factor activity
I6I31_RS02785	COG3588	fructose-bisphosphate aldolase
I6I31_RS02795	COG0579	oxidoreductase
I6I31_RS02800	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6I31_RS02805	COG0574	Belongs to the PEP-utilizing enzyme family
I6I31_RS02805	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I31_RS02835	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6I31_RS02840	COG1012	belongs to the aldehyde dehydrogenase family
I6I31_RS02845	COG1510	regulation of RNA biosynthetic process
I6I31_RS02855	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6I31_RS02860	COG0602	queuosine metabolic process
I6I31_RS02865	COG1328	CTP reductase activity
I6I31_RS02875	COG3942	CHAP domain
I6I31_RS02895	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I31_RS02895	COG1648	precorrin-2 dehydrogenase activity
I6I31_RS02910	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I6I31_RS02920	COG0386	Belongs to the glutathione peroxidase family
I6I31_RS02930	COG1846	Transcriptional regulator
I6I31_RS02955	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I31_RS02970	COG1136	(ABC) transporter
I6I31_RS02975	COG2205	protein histidine kinase activity
I6I31_RS02980	COG0745	RESPONSE REGULATOR receiver
I6I31_RS02990	COG1785	Belongs to the alkaline phosphatase family
I6I31_RS02995	COG1316	TRANSCRIPTIONal
I6I31_RS03000	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6I31_RS03010	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6I31_RS03040	COG0438	transferase activity, transferring glycosyl groups
I6I31_RS03095	COG1846	Transcriptional regulator
I6I31_RS03100	COG3961	Belongs to the TPP enzyme family
I6I31_RS03105	COG1045	serine acetyltransferase
I6I31_RS03145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I31_RS03155	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6I31_RS03160	COG2235	arginine
I6I31_RS03165	COG1438	arginine binding
I6I31_RS03220	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I31_RS03220	COG3711	transcriptional antiterminator
I6I31_RS03225	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I31_RS03225	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I31_RS03225	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I31_RS03230	COG1482	cell wall glycoprotein biosynthetic process
I6I31_RS03240	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6I31_RS03240	COG3942	CHAP domain
I6I31_RS03280	COG2814	Major facilitator Superfamily
I6I31_RS03330	COG2814	Major facilitator Superfamily
I6I31_RS03350	COG1309	transcriptional regulator
I6I31_RS03395	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6I31_RS03405	COG0131	Imidazoleglycerol-phosphate dehydratase
I6I31_RS03425	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I6I31_RS03470	COG0579	oxidoreductase
I6I31_RS03485	COG2353	YceI-like domain
I6I31_RS03505	COG0471	metal ion transport
I6I31_RS03515	COG2962	Rard protein
I6I31_RS03540	COG2814	Major facilitator Superfamily
I6I31_RS03595	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I6I31_RS03600	COG1461	Dihydroxyacetone kinase
I6I31_RS03605	COG2376	Dihydroxyacetone kinase
I6I31_RS03615	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6I31_RS03620	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I6I31_RS03630	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6I31_RS03635	COG0549	Belongs to the carbamate kinase family
I6I31_RS03640	COG1288	antiporter activity
I6I31_RS03690	COG1131	(ABC) transporter
I6I31_RS03710	COG1114	Component of the transport system for branched-chain amino acids
I6I31_RS03725	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6I31_RS03730	COG1882	Formate acetyltransferase
I6I31_RS03800	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6I31_RS03810	COG2205	protein histidine kinase activity
I6I31_RS03815	COG0745	RESPONSE REGULATOR receiver
I6I31_RS03840	COG0601	transmembrane transport
I6I31_RS03870	COG1028	Short-chain dehydrogenase reductase Sdr
I6I31_RS03890	COG0583	DNA-binding transcription factor activity
I6I31_RS03895	COG2855	membrane
I6I31_RS03920	COG5492	domain, Protein
I6I31_RS03940	COG1169	isochorismate synthase
I6I31_RS03995	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6I31_RS04005	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I6I31_RS04040	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
I6I31_RS04050	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6I31_RS04055	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6I31_RS04085	COG2188	Transcriptional regulator
I6I31_RS04090	COG0813	purine-nucleoside phosphorylase activity
I6I31_RS04095	COG2814	Major facilitator Superfamily
I6I31_RS04100	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6I31_RS04130	COG0579	oxidoreductase
I6I31_RS04135	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6I31_RS04155	COG1063	alcohol dehydrogenase
I6I31_RS04160	COG0693	protein deglycase activity
I6I31_RS04215	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I6I31_RS04220	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I6I31_RS04225	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6I31_RS04235	COG4863	YycH protein
I6I31_RS04240	COG5002	protein histidine kinase activity
I6I31_RS04245	COG0745	RESPONSE REGULATOR receiver
I6I31_RS04260	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6I31_RS04265	COG0305	Participates in initiation and elongation during chromosome replication
I6I31_RS04270	COG0359	binds to the 23S rRNA
I6I31_RS04275	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I6I31_RS04285	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I31_RS04305	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6I31_RS04315	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6I31_RS04320	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6I31_RS04325	COG0187	DNA topoisomerase II activity
I6I31_RS04330	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I31_RS04335	COG2501	S4 domain
I6I31_RS04340	COG0592	DNA-directed DNA polymerase activity
I6I31_RS04345	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I31_RS04355	COG0594	ribonuclease P activity
I6I31_RS04360	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I6I31_RS04365	COG0445	tRNA wobble uridine modification
I6I31_RS04370	COG0357	Ribosomal RNA small subunit methyltransferase G
I6I31_RS04375	COG1475	DNA binding
I6I31_RS04380	COG0531	amino acid
I6I31_RS04390	COG0686	Belongs to the AlaDH PNT family
I6I31_RS04460	COG0577	efflux transmembrane transporter activity
I6I31_RS04465	COG1136	(ABC) transporter
I6I31_RS04485	COG2814	Major facilitator Superfamily
I6I31_RS04495	COG3266	domain, Protein
I6I31_RS04495	COG4932	domain protein
I6I31_RS04495	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
I6I31_RS04530	COG1476	TRANSCRIPTIONal
I6I31_RS04540	COG0183	Belongs to the thiolase family
I6I31_RS04565	COG1475	DNA binding
I6I31_RS04570	COG0668	transmembrane transport
I6I31_RS04575	COG4481	Protein conserved in bacteria
I6I31_RS04580	COG0012	GTP binding
I6I31_RS04595	COG0360	Binds together with S18 to 16S ribosomal RNA
I6I31_RS04605	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6I31_RS04610	COG0582	viral genome integration into host DNA
I6I31_RS04725	COG2244	polysaccharide biosynthetic process
I6I31_RS04765	COG3634	alkyl hydroperoxide reductase activity
I6I31_RS04770	COG0450	alkyl hydroperoxide reductase
I6I31_RS04780	COG0778	Nitroreductase
I6I31_RS04805	COG5183	chlorophyll binding
I6I31_RS04820	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I31_RS04825	COG2233	PERMEase
I6I31_RS04830	COG0516	GMP reductase activity
I6I31_RS04830	COG0517	IMP dehydrogenase activity
I6I31_RS04835	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6I31_RS04835	COG0519	Catalyzes the synthesis of GMP from XMP
I6I31_RS04860	COG2211	Major facilitator Superfamily
I6I31_RS04915	COG1647	Serine aminopeptidase, S33
I6I31_RS04925	COG0733	neurotransmitter:sodium symporter activity
I6I31_RS04955	COG2011	ABC-type metal ion transport system permease component
I6I31_RS04965	COG3942	CHAP domain
I6I31_RS04965	COG1388	LysM domain
I6I31_RS05035	COG2188	Transcriptional regulator
I6I31_RS05050	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6I31_RS05055	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I6I31_RS05085	COG1982	Orn Lys Arg decarboxylase major
I6I31_RS05090	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6I31_RS05095	COG3870	Protein conserved in bacteria
I6I31_RS05100	COG0470	DNA polymerase III
I6I31_RS05105	COG1774	PSP1 C-terminal conserved region
I6I31_RS05110	COG4467	Involved in initiation control of chromosome replication
I6I31_RS05115	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I6I31_RS05120	COG2827	Endonuclease containing a URI domain
I6I31_RS05125	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6I31_RS05130	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I31_RS05130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I31_RS05135	COG0084	hydrolase, TatD family'
I6I31_RS05140	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I6I31_RS05145	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6I31_RS05150	COG4466	Protein conserved in bacteria
I6I31_RS05155	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I6I31_RS05160	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I6I31_RS05170	COG2088	sporulation resulting in formation of a cellular spore
I6I31_RS05175	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I31_RS05180	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6I31_RS05185	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I6I31_RS05190	COG0193	aminoacyl-tRNA hydrolase activity
I6I31_RS05195	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6I31_RS05210	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6I31_RS05220	COG1098	S1 RNA binding domain
I6I31_RS05225	COG0037	tRNA processing
I6I31_RS05230	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6I31_RS05235	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I31_RS05240	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6I31_RS05245	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I31_RS05250	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6I31_RS05255	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6I31_RS05260	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6I31_RS05265	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6I31_RS05340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I31_RS05345	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I6I31_RS05350	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I6I31_RS05355	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6I31_RS05360	COG4463	regulation of RNA biosynthetic process
I6I31_RS05365	COG3880	PFAM UvrB UvrC protein
I6I31_RS05370	COG3869	Catalyzes the specific phosphorylation of arginine residues in
I6I31_RS05375	COG0542	response to heat
I6I31_RS05380	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6I31_RS05385	COG4956	integral membrane protein (PIN domain superfamily)
I6I31_RS05390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I31_RS05395	COG1045	serine acetyltransferase
I6I31_RS05400	COG0215	cysteine-tRNA ligase activity
I6I31_RS05405	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I6I31_RS05410	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I31_RS05415	COG3688	RNA-binding protein containing a PIN domain
I6I31_RS05425	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6I31_RS05430	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6I31_RS05435	COG0250	Participates in transcription elongation, termination and antitermination
I6I31_RS05440	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6I31_RS05445	COG0081	regulation of translation
I6I31_RS05450	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6I31_RS05455	COG0222	ribosome binding
I6I31_RS05460	COG2813	Specifically methylates the guanine in position
I6I31_RS05465	COG0085	RNA polymerase activity
I6I31_RS05470	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6I31_RS05480	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6I31_RS05490	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6I31_RS05495	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I31_RS05530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I31_RS05550	COG0546	phosphoglycolate phosphatase activity
I6I31_RS05565	COG1428	Deoxynucleoside kinase
I6I31_RS05570	COG1428	Deoxynucleoside kinase
I6I31_RS05580	COG0561	phosphatase activity
I6I31_RS05585	COG0431	NADPH-dependent FMN reductase
I6I31_RS05615	COG1469	GTP cyclohydrolase I activity
I6I31_RS05625	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6I31_RS05630	COG0363	glucosamine-6-phosphate deaminase activity
I6I31_RS05635	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I6I31_RS05660	COG0477	Major facilitator Superfamily
I6I31_RS05675	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I6I31_RS05680	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6I31_RS05690	COG2363	Small membrane protein
I6I31_RS05695	COG0531	amino acid
I6I31_RS05710	COG3253	May function as heme-dependent peroxidase
I6I31_RS05715	COG0280	phosphate acetyltransferase
I6I31_RS05720	COG0095	Lipoate-protein ligase
I6I31_RS05760	COG4844	belongs to the
I6I31_RS05780	COG0655	NAD(P)H dehydrogenase (quinone) activity
I6I31_RS05790	COG1078	dGTPase activity
I6I31_RS05800	COG1064	alcohol dehydrogenase
I6I31_RS05815	COG0018	arginyl-trna synthetase
I6I31_RS05820	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6I31_RS05835	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I31_RS05845	COG0546	phosphoglycolate phosphatase activity
I6I31_RS05905	COG2111	Na H antiporter
I6I31_RS05910	COG1006	Multisubunit Na H antiporter MnhC subunit
I6I31_RS05915	COG0651	ATP synthesis coupled electron transport
I6I31_RS05920	COG1863	multisubunit Na H antiporter MnhE subunit
I6I31_RS05930	COG1320	monovalent cation:proton antiporter activity
I6I31_RS05955	COG1321	iron dependent repressor
I6I31_RS05965	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I6I31_RS05970	COG1134	teichoic acid transport
I6I31_RS05975	COG1682	transport, permease protein
I6I31_RS05980	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I6I31_RS05990	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6I31_RS05995	COG1132	(ABC) transporter
I6I31_RS06000	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6I31_RS06010	COG1120	ATPase activity
I6I31_RS06020	COG3949	Membrane
I6I31_RS06025	COG0657	acetylesterase activity
I6I31_RS06035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6I31_RS06040	COG0745	RESPONSE REGULATOR receiver
I6I31_RS06045	COG2205	protein histidine kinase activity
I6I31_RS06050	COG1136	(ABC) transporter
I6I31_RS06055	COG0577	efflux transmembrane transporter activity
I6I31_RS06060	COG1392	Phosphate transport regulator
I6I31_RS06065	COG0306	phosphate transporter
I6I31_RS06070	COG1388	LysM domain
I6I31_RS06070	COG3942	CHAP domain
I6I31_RS06090	COG0217	transcriptional regulatory protein
I6I31_RS06120	COG0583	DNA-binding transcription factor activity
I6I31_RS06125	COG2814	Major facilitator Superfamily
I6I31_RS06130	COG2839	Protein conserved in bacteria
I6I31_RS06155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I31_RS06160	COG1611	Belongs to the LOG family
I6I31_RS06165	COG1671	Belongs to the UPF0178 family
I6I31_RS06175	COG1968	undecaprenyl-diphosphatase activity
I6I31_RS06200	COG0415	Belongs to the DNA photolyase family
I6I31_RS06230	COG1349	DNA-binding transcription factor activity
I6I31_RS06235	COG1105	Belongs to the carbohydrate kinase PfkB family
I6I31_RS06240	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I31_RS06240	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I31_RS06240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I31_RS06245	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6I31_RS06250	COG1253	flavin adenine dinucleotide binding
I6I31_RS06260	COG0463	Glycosyl transferase, family 2
I6I31_RS06265	COG5002	protein histidine kinase activity
I6I31_RS06290	COG0602	queuosine metabolic process
I6I31_RS06295	COG0720	synthase
I6I31_RS06300	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I6I31_RS06305	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I31_RS06305	COG0512	Glutamine amidotransferase of anthranilate synthase
I6I31_RS06310	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6I31_RS06330	COG1368	sulfuric ester hydrolase activity
I6I31_RS06345	COG0514	ATP-dependent DNA helicase (RecQ)
I6I31_RS06355	COG1174	glycine betaine transport
I6I31_RS06370	COG1454	alcohol dehydrogenase
I6I31_RS06370	COG1012	belongs to the aldehyde dehydrogenase family
I6I31_RS06380	COG3104	oligopeptide transport
I6I31_RS06385	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I6I31_RS06390	COG0697	spore germination
I6I31_RS06395	COG1780	Probably involved in ribonucleotide reductase function
I6I31_RS06400	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I31_RS06405	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I31_RS06410	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I31_RS06435	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6I31_RS06455	COG1929	Belongs to the glycerate kinase type-1 family
I6I31_RS06460	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6I31_RS06475	COG2199	diguanylate cyclase activity
I6I31_RS06480	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I31_RS06485	COG1739	Uncharacterized protein family UPF0029
I6I31_RS06505	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6I31_RS06515	COG0653	protein targeting
I6I31_RS06540	COG0556	nucleotide-excision repair
I6I31_RS06545	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6I31_RS06550	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I6I31_RS06555	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6I31_RS06570	COG0492	ferredoxin-NADP+ reductase activity
I6I31_RS06575	COG1660	Displays ATPase and GTPase activities
I6I31_RS06580	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6I31_RS06585	COG1481	regulation of sporulation
I6I31_RS06595	COG0740	serine-type endopeptidase activity
I6I31_RS06605	COG1090	epimerase
I6I31_RS06630	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6I31_RS06635	COG0126	phosphoglycerate kinase activity
I6I31_RS06640	COG0149	triose-phosphate isomerase activity
I6I31_RS06645	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I6I31_RS06650	COG0148	phosphopyruvate hydratase activity
I6I31_RS06660	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6I31_RS06665	COG1647	Serine aminopeptidase, S33
I6I31_RS06670	COG0557	exoribonuclease II activity
I6I31_RS06675	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I6I31_RS06735	COG1278	Cold shock
I6I31_RS06750	COG4195	phage-related replication protein
I6I31_RS06795	COG1764	response to oxidative stress
I6I31_RS06800	COG0710	3-dehydroquinate dehydratase activity
I6I31_RS06810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I31_RS06815	COG1393	Belongs to the ArsC family
I6I31_RS06820	COG0509	glycine decarboxylation via glycine cleavage system
I6I31_RS06825	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I6I31_RS06830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I31_RS06835	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6I31_RS06845	COG1464	Belongs to the NlpA lipoprotein family
I6I31_RS06855	COG3237	CsbD-like
I6I31_RS06865	COG0396	ATPase activity
I6I31_RS06870	COG0719	Fe-S assembly protein
I6I31_RS06875	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6I31_RS06880	COG0822	iron-sulfur transferase activity
I6I31_RS06885	COG0719	Fe-S assembly protein
I6I31_RS06915	COG1801	Protein of unknown function DUF72
I6I31_RS06920	COG0730	response to heat
I6I31_RS06925	COG0737	Belongs to the 5'-nucleotidase family
I6I31_RS06930	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I31_RS06935	COG4470	Protein conserved in bacteria
I6I31_RS06945	COG2445	Protein of unknown function DUF86
I6I31_RS06950	COG0647	UMP catabolic process
I6I31_RS06955	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I31_RS06965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I31_RS06970	COG1696	Membrane protein involved in D-alanine export
I6I31_RS06980	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I6I31_RS06985	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I6I31_RS06990	COG4837	Protein of unknown function (DUF1462)
I6I31_RS07000	COG4844	belongs to the
I6I31_RS07005	COG0316	Belongs to the HesB IscA family
I6I31_RS07010	COG1252	NADH dehydrogenase
I6I31_RS07015	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I6I31_RS07020	COG2056	Na+-H+ antiporter family
I6I31_RS07025	COG2050	protein possibly involved in aromatic compounds catabolism
I6I31_RS07035	COG1320	monovalent cation:proton antiporter activity
I6I31_RS07040	COG2212	antiporter activity
I6I31_RS07045	COG1863	multisubunit Na H antiporter MnhE subunit
I6I31_RS07050	COG0651	ATP synthesis coupled electron transport
I6I31_RS07055	COG1006	Multisubunit Na H antiporter MnhC subunit
I6I31_RS07060	COG2111	Na H antiporter
I6I31_RS07065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I31_RS07065	COG2111	Na H antiporter
I6I31_RS07075	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6I31_RS07080	COG1098	S1 RNA binding domain
I6I31_RS07085	COG1902	pentaerythritol trinitrate reductase activity
I6I31_RS07100	COG0584	glycerophosphoryl diester phosphodiesterase
I6I31_RS07105	COG0165	Argininosuccinate lyase
I6I31_RS07110	COG0137	argininosuccinate synthase activity
I6I31_RS07115	COG0166	Belongs to the GPI family
I6I31_RS07120	COG0398	Pfam SNARE associated Golgi protein
I6I31_RS07135	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I6I31_RS07140	COG1074	ATP-dependent DNA helicase activity
I6I31_RS07145	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I31_RS07160	COG0561	phosphatase activity
I6I31_RS07175	COG0542	response to heat
I6I31_RS07185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6I31_RS07220	COG0180	Tryptophanyl-tRNA synthetase
I6I31_RS07225	COG1393	Belongs to the ArsC family
I6I31_RS07230	COG4862	establishment of competence for transformation
I6I31_RS07240	COG1164	Oligoendopeptidase f
I6I31_RS07245	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6I31_RS07265	COG2357	RelA SpoT domain protein
I6I31_RS07270	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6I31_RS07275	COG0564	pseudouridine synthase activity
I6I31_RS07280	COG2239	Acts as a magnesium transporter
I6I31_RS07295	COG0628	permease
I6I31_RS07305	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6I31_RS07310	COG2814	Major facilitator Superfamily
I6I31_RS07315	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I31_RS07320	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I31_RS07330	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6I31_RS07335	COG0861	Integral membrane protein TerC family
I6I31_RS07340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I31_RS07345	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I31_RS07360	COG4873	Protein conserved in bacteria
I6I31_RS07430	COG1575	Belongs to the MenA family. Type 1 subfamily
I6I31_RS07435	COG1169	isochorismate synthase
I6I31_RS07440	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I6I31_RS07445	COG0596	Alpha beta hydrolase
I6I31_RS07450	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6I31_RS07455	COG0436	Aminotransferase
I6I31_RS07470	COG5632	N-Acetylmuramoyl-L-alanine amidase
I6I31_RS07470	COG3266	domain, Protein
I6I31_RS07470	COG4193	domain, Protein
I6I31_RS07485	COG1316	TRANSCRIPTIONal
I6I31_RS07490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I31_RS07505	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6I31_RS07510	COG1845	cytochrome c oxidase, subunit III
I6I31_RS07515	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I31_RS07520	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6I31_RS07525	COG4932	domain protein
I6I31_RS07525	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
I6I31_RS07525	COG3266	domain, Protein
I6I31_RS07550	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6I31_RS07555	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6I31_RS07560	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6I31_RS07565	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I31_RS07570	COG0047	phosphoribosylformylglycinamidine synthase activity
I6I31_RS07575	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I31_RS07580	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6I31_RS07585	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6I31_RS07590	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6I31_RS07595	COG0138	bifunctional purine biosynthesis protein purh
I6I31_RS07600	COG0151	Belongs to the GarS family
I6I31_RS07605	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6I31_RS07610	COG4172	Belongs to the ABC transporter superfamily
I6I31_RS07630	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I6I31_RS07640	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I31_RS07645	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I31_RS07665	COG0569	domain protein
I6I31_RS07670	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6I31_RS07675	COG5503	Protein of unknown function (DUF1447)
I6I31_RS07680	COG0242	peptide deformylase activity
I6I31_RS07690	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6I31_RS07695	COG0022	dehydrogenase e1 component
I6I31_RS07700	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I31_RS07710	COG4476	Belongs to the UPF0223 family
I6I31_RS07725	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6I31_RS07730	COG1177	transmembrane transport
I6I31_RS07735	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6I31_RS07750	COG1914	H( )-stimulated, divalent metal cation uptake system
I6I31_RS07760	COG0483	inositol monophosphate 1-phosphatase activity
I6I31_RS07770	COG1217	gtp-binding protein TYPA
I6I31_RS07775	COG4896	Protein conserved in bacteria
I6I31_RS07780	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6I31_RS07785	COG4838	Belongs to the UPF0358 family
I6I31_RS07790	COG0772	Belongs to the SEDS family
I6I31_RS07800	COG1612	heme a metabolic process
I6I31_RS07805	COG0109	protoheme IX farnesyltransferase activity
I6I31_RS07815	COG2340	Cysteine-rich secretory protein family
I6I31_RS07820	COG3679	Belongs to the UPF0342 family
I6I31_RS07840	COG4471	UPF0298 protein
I6I31_RS07850	COG0742	ribosomal rna small subunit methyltransferase
I6I31_RS07855	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6I31_RS07860	COG1323	Belongs to the UPF0348 family
I6I31_RS07870	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I6I31_RS07885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I31_RS07890	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I6I31_RS07895	COG0072	phenylalanine-tRNA ligase activity
I6I31_RS07895	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I31_RS07900	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6I31_RS07905	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
I6I31_RS07915	COG1796	DNA polymerase
I6I31_RS07915	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6I31_RS07920	COG1193	negative regulation of DNA recombination
I6I31_RS07925	COG3118	belongs to the thioredoxin family
I6I31_RS07930	COG0322	excinuclease ABC activity
I6I31_RS07935	COG2009	succinate dehydrogenase
I6I31_RS07940	COG1053	succinate dehydrogenase
I6I31_RS07945	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6I31_RS07950	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6I31_RS07955	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6I31_RS07990	COG0454	-acetyltransferase
I6I31_RS07995	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
I6I31_RS08005	COG0275	rRNA processing
I6I31_RS08010	COG4839	cell division protein FtsL
I6I31_RS08015	COG0768	penicillin binding
I6I31_RS08020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I31_RS08025	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6I31_RS08030	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6I31_RS08035	COG0849	cell division
I6I31_RS08040	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6I31_RS08045	COG1496	oxidoreductase activity
I6I31_RS08050	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6I31_RS08055	COG1799	cell septum assembly
I6I31_RS08060	COG0762	integral membrane protein
I6I31_RS08070	COG3599	regulation of cell shape
I6I31_RS08075	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6I31_RS08090	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6I31_RS08095	COG0564	pseudouridine synthase activity
I6I31_RS08100	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I6I31_RS08105	COG2233	PERMEase
I6I31_RS08110	COG0540	Belongs to the ATCase OTCase family
I6I31_RS08115	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6I31_RS08120	COG0505	Belongs to the CarA family
I6I31_RS08125	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6I31_RS08130	COG0284	orotidine-5'-phosphate decarboxylase activity
I6I31_RS08135	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6I31_RS08150	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I6I31_RS08155	COG0194	GDP metabolic process
I6I31_RS08160	COG1758	RNA polymerase activity
I6I31_RS08165	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6I31_RS08170	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6I31_RS08180	COG0242	peptide deformylase activity
I6I31_RS08185	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I31_RS08190	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6I31_RS08190	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I31_RS08195	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6I31_RS08200	COG0631	protein serine/threonine phosphatase activity
I6I31_RS08210	COG1162	GTPase activity
I6I31_RS08215	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6I31_RS08220	COG1564	THIamine pyrophosphokinase
I6I31_RS08225	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6I31_RS08230	COG1302	Protein conserved in bacteria
I6I31_RS08235	COG1461	Dihydroxyacetone kinase
I6I31_RS08245	COG1525	nuclease
I6I31_RS08250	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6I31_RS08255	COG1349	DNA-binding transcription factor activity
I6I31_RS08260	COG0416	fatty acid biosynthetic process
I6I31_RS08270	COG1028	Short-chain dehydrogenase reductase Sdr
I6I31_RS08275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I31_RS08280	COG0571	ribonuclease III activity
I6I31_RS08285	COG1196	nuclear chromosome segregation
I6I31_RS08290	COG0552	protein localization to endoplasmic reticulum
I6I31_RS08295	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I6I31_RS08300	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6I31_RS08305	COG0228	four-way junction DNA binding
I6I31_RS08310	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I6I31_RS08315	COG0336	Belongs to the RNA methyltransferase TrmD family
I6I31_RS08320	COG0335	large ribosomal subunit rRNA binding
I6I31_RS08340	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6I31_RS08345	COG0045	succinate-CoA ligase (ADP-forming) activity
I6I31_RS08350	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6I31_RS08360	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6I31_RS08365	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I6I31_RS08370	COG4974	Belongs to the 'phage' integrase family
I6I31_RS08375	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6I31_RS08385	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I6I31_RS08390	COG0052	Belongs to the universal ribosomal protein uS2 family
I6I31_RS08395	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6I31_RS08400	COG0528	UMP kinase activity
I6I31_RS08405	COG0233	cytoplasmic translational termination
I6I31_RS08410	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6I31_RS08415	COG4589	Belongs to the CDS family
I6I31_RS08425	COG0442	prolyl-tRNA aminoacylation
I6I31_RS08430	COG2176	DNA-directed DNA polymerase activity
I6I31_RS08435	COG0779	Required for maturation of 30S ribosomal subunits
I6I31_RS08440	COG0195	Participates in both transcription termination and antitermination
I6I31_RS08445	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I6I31_RS08455	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6I31_RS08460	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6I31_RS08465	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6I31_RS08470	COG0196	riboflavin kinase activity
I6I31_RS08475	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6I31_RS08480	COG1185	polyribonucleotide nucleotidyltransferase activity
I6I31_RS08485	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6I31_RS08490	COG1674	ftsk spoiiie
I6I31_RS08495	COG2188	Transcriptional regulator
I6I31_RS08500	COG0612	Peptidase, M16
I6I31_RS08505	COG0612	Peptidase, M16
I6I31_RS08510	COG0300	oxidoreductase activity
I6I31_RS08525	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6I31_RS08530	COG1546	Belongs to the CinA family
I6I31_RS08530	COG1058	Belongs to the CinA family
I6I31_RS08535	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6I31_RS08540	COG1418	mRNA catabolic process
I6I31_RS08550	COG1692	metallophosphoesterase
I6I31_RS08555	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6I31_RS08555	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6I31_RS08560	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6I31_RS08565	COG4195	phage-related replication protein
I6I31_RS08575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I31_RS08580	COG4550	Control of competence regulator ComK, YlbF/YmcA
I6I31_RS08590	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6I31_RS08595	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6I31_RS08600	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I6I31_RS08605	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6I31_RS08610	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6I31_RS08615	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6I31_RS08625	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I6I31_RS08630	COG1923	regulation of RNA biosynthetic process
I6I31_RS08635	COG0386	Belongs to the glutathione peroxidase family
I6I31_RS08645	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I6I31_RS08650	COG0789	Transcriptional regulator
I6I31_RS08655	COG0174	glutamine synthetase
I6I31_RS08745	COG0527	aspartate kinase activity
I6I31_RS08750	COG0460	homoserine dehydrogenase
I6I31_RS08755	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6I31_RS08760	COG0083	homoserine kinase activity
I6I31_RS08775	COG0833	amino acid
I6I31_RS08790	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6I31_RS08805	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I31_RS08815	COG4224	UPF0291 protein
I6I31_RS08820	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6I31_RS08830	COG4846	Membrane protein involved in cytochrome C biogenesis
I6I31_RS08840	COG0419	ATPase involved in DNA repair
I6I31_RS08845	COG1970	mechanosensitive ion channel activity
I6I31_RS08850	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I31_RS08855	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6I31_RS08870	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I6I31_RS08875	COG0187	DNA topoisomerase II activity
I6I31_RS08880	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6I31_RS08885	COG1115	amino acid carrier protein
I6I31_RS08890	COG3711	transcriptional antiterminator
I6I31_RS08895	COG0628	permease
I6I31_RS08900	COG0392	lysyltransferase activity
I6I31_RS08900	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6I31_RS08915	COG1942	4-Oxalocrotonate Tautomerase
I6I31_RS08920	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I31_RS08955	COG2348	transferase activity, transferring amino-acyl groups
I6I31_RS08960	COG2348	transferase activity, transferring amino-acyl groups
I6I31_RS09000	COG1164	Oligoendopeptidase f
I6I31_RS09005	COG0704	Plays a role in the regulation of phosphate uptake
I6I31_RS09010	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6I31_RS09015	COG0581	inorganic phosphate transmembrane transporter activity
I6I31_RS09020	COG0573	inorganic phosphate transmembrane transporter activity
I6I31_RS09025	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6I31_RS09035	COG2996	Protein conserved in bacteria
I6I31_RS09040	COG0488	(ABC) transporter
I6I31_RS09045	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6I31_RS09050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I31_RS09055	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6I31_RS09065	COG1473	amidohydrolase
I6I31_RS09100	COG1278	Cold shock
I6I31_RS09110	COG1254	Belongs to the acylphosphatase family
I6I31_RS09125	COG1114	Component of the transport system for branched-chain amino acids
I6I31_RS09165	COG5002	protein histidine kinase activity
I6I31_RS09170	COG0745	RESPONSE REGULATOR receiver
I6I31_RS09180	COG0534	Mate efflux family protein
I6I31_RS09200	COG4209	transmembrane transport
I6I31_RS09205	COG4209	transmembrane transport
I6I31_RS09215	COG0671	phosphoesterase, PA-phosphatase related
I6I31_RS09220	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I31_RS09230	COG0793	Belongs to the peptidase S41A family
I6I31_RS09235	COG4479	Belongs to the UPF0346 family
I6I31_RS09240	COG2190	(PTS) system
I6I31_RS09275	COG1413	lyase activity
I6I31_RS09280	COG1413	lyase activity
I6I31_RS09290	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6I31_RS09320	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I31_RS09325	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I6I31_RS09335	COG0116	Belongs to the methyltransferase superfamily
I6I31_RS09345	COG3599	regulation of cell shape
I6I31_RS09350	COG4474	Belongs to the UPF0398 family
I6I31_RS09360	COG3331	DNA recombination
I6I31_RS09365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I31_RS09365	COG4499	WXG100 protein secretion system (Wss), protein YukC
I6I31_RS09375	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6I31_RS09380	COG3935	DnaD domain protein
I6I31_RS09385	COG0017	Asparaginyl-tRNA synthetase
I6I31_RS09390	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6I31_RS09390	COG1199	ATP-dependent helicase activity
I6I31_RS09395	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6I31_RS09395	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6I31_RS09400	COG0617	tRNA 3'-terminal CCA addition
I6I31_RS09405	COG0438	transferase activity, transferring glycosyl groups
I6I31_RS09410	COG1694	Mazg nucleotide pyrophosphohydrolase
I6I31_RS09415	COG2738	Putative neutral zinc metallopeptidase
I6I31_RS09425	COG5582	Belongs to the UPF0302 family
I6I31_RS09435	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6I31_RS09440	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I6I31_RS09445	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6I31_RS09450	COG0105	UTP biosynthetic process
I6I31_RS09460	COG2226	methyltransferase
I6I31_RS09475	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6I31_RS09480	COG1160	GTP binding
I6I31_RS09485	COG0539	negative regulation of cytoplasmic translation
I6I31_RS09490	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6I31_RS09500	COG0492	ferredoxin-NADP+ reductase activity
I6I31_RS09505	COG1388	LysM domain
I6I31_RS09510	COG0514	ATP-dependent DNA helicase (RecQ)
I6I31_RS09520	COG1141	Ferredoxin
I6I31_RS09535	COG0745	RESPONSE REGULATOR receiver
I6I31_RS09540	COG1187	pseudouridine synthase activity
I6I31_RS09545	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6I31_RS09550	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6I31_RS09560	COG4974	Belongs to the 'phage' integrase family
I6I31_RS09565	COG0735	belongs to the Fur family
I6I31_RS09570	COG0494	nUDIX hydrolase
I6I31_RS09590	COG1234	tRNA 3'-trailer cleavage
I6I31_RS09595	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6I31_RS09610	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6I31_RS09615	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6I31_RS09625	COG4129	membrane
I6I31_RS09635	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I31_RS09640	COG0022	dehydrogenase e1 component
I6I31_RS09645	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6I31_RS09650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I31_RS09655	COG0497	DNA recombination
I6I31_RS09660	COG1438	arginine binding
I6I31_RS09675	COG1570	exodeoxyribonuclease VII activity
I6I31_RS09680	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I31_RS09685	COG1302	Protein conserved in bacteria
I6I31_RS09690	COG0439	Biotin carboxylase
I6I31_RS09695	COG0511	ligase activity, forming carbon-carbon bonds
I6I31_RS09710	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6I31_RS09720	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I31_RS09725	COG0006	proline dipeptidase activity
I6I31_RS09740	COG0095	Lipoate-protein ligase
I6I31_RS09745	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I31_RS09750	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I31_RS09755	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I31_RS09760	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6I31_RS09765	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6I31_RS09780	COG1459	type II secretion system
I6I31_RS09790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I31_RS09795	COG0011	TIGRFAM Protein of
I6I31_RS09800	COG1940	carbohydrate kinase activity
I6I31_RS09805	COG4483	Protein conserved in bacteria
I6I31_RS09815	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6I31_RS09820	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6I31_RS09825	COG0768	penicillin binding
I6I31_RS09830	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6I31_RS09840	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I31_RS09845	COG1121	(ABC) transporter
I6I31_RS09850	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I6I31_RS09855	COG0513	Belongs to the DEAD box helicase family
I6I31_RS09860	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6I31_RS09865	COG2384	SAM-dependent methyltransferase
I6I31_RS09870	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6I31_RS09875	COG0358	DNA primase activity
I6I31_RS09880	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I6I31_RS09885	COG0517	IMP dehydrogenase activity
I6I31_RS09890	COG0423	glycine-tRNA ligase activity
I6I31_RS09895	COG1381	Involved in DNA repair and RecF pathway recombination
I6I31_RS09900	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6I31_RS09915	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6I31_RS09920	COG1702	phosphate starvation-inducible protein PhoH
I6I31_RS09930	COG4864	UPF0365 protein
I6I31_RS09935	COG1030	water channel activity
I6I31_RS09945	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6I31_RS09950	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6I31_RS09955	COG2264	protein methyltransferase activity
I6I31_RS09960	COG0484	heat shock protein binding
I6I31_RS09965	COG0443	Heat shock 70 kDa protein
I6I31_RS09970	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I6I31_RS09975	COG1420	regulation of RNA biosynthetic process
I6I31_RS09980	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6I31_RS09985	COG0481	GTPase activity
I6I31_RS09990	COG0268	Binds directly to 16S ribosomal RNA
I6I31_RS09995	COG1466	dna polymerase III delta subunit
I6I31_RS10005	COG2131	deaminase
I6I31_RS10010	COG1596	polysaccharide export
I6I31_RS10010	COG1555	photosystem II stabilization
I6I31_RS10020	COG0799	negative regulation of ribosome biogenesis
I6I31_RS10025	COG1713	HD superfamily hydrolase involved in NAD metabolism
I6I31_RS10030	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6I31_RS10035	COG1534	Rna-binding protein
I6I31_RS10040	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I31_RS10045	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I6I31_RS10050	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I6I31_RS10055	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6I31_RS10065	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6I31_RS10070	COG0439	Biotin carboxylase
I6I31_RS10075	COG0511	ligase activity, forming carbon-carbon bonds
I6I31_RS10080	COG1984	allophanate hydrolase subunit 2
I6I31_RS10085	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6I31_RS10090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6I31_RS10095	COG0572	uridine kinase
I6I31_RS10100	COG0826	peptidase U32
I6I31_RS10105	COG0826	peptidase U32
I6I31_RS10115	COG3906	Belongs to the UPF0473 family
I6I31_RS10120	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6I31_RS10125	COG4472	Bacterial protein of unknown function (DUF965)
I6I31_RS10130	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6I31_RS10135	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6I31_RS10145	COG0482	sulfurtransferase activity
I6I31_RS10150	COG1104	cysteine desulfurase activity
I6I31_RS10155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I31_RS10165	COG1959	2 iron, 2 sulfur cluster binding
I6I31_RS10170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6I31_RS10175	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6I31_RS10185	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6I31_RS10190	COG0124	histidyl-tRNA synthetase
I6I31_RS10195	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I31_RS10200	COG1490	D-aminoacyl-tRNA deacylase activity
I6I31_RS10205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I31_RS10215	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6I31_RS10215	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I6I31_RS10220	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I31_RS10220	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I31_RS10225	COG1862	Preprotein translocase
I6I31_RS10230	COG0343	queuine tRNA-ribosyltransferase activity
I6I31_RS10235	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I6I31_RS10240	COG2255	four-way junction helicase activity
I6I31_RS10245	COG0632	four-way junction helicase activity
I6I31_RS10255	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I6I31_RS10260	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6I31_RS10265	COG2868	ribosomal protein
I6I31_RS10270	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6I31_RS10305	COG0285	dihydrofolate synthase activity
I6I31_RS10310	COG0525	valine-tRNA ligase activity
I6I31_RS10315	COG2818	Glycosylase
I6I31_RS10325	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6I31_RS10330	COG0113	porphobilinogen synthase activity
I6I31_RS10335	COG0181	hydroxymethylbilane synthase activity
I6I31_RS10345	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6I31_RS10350	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6I31_RS10355	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6I31_RS10360	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6I31_RS10370	COG4112	unkown
I6I31_RS10375	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6I31_RS10380	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6I31_RS10385	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6I31_RS10390	COG0833	amino acid
I6I31_RS10395	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6I31_RS10400	COG1484	DNA-dependent DNA replication
I6I31_RS10405	COG3611	Membrane attachment protein
I6I31_RS10410	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6I31_RS10415	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6I31_RS10420	COG0237	dephospho-CoA kinase activity
I6I31_RS10430	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I31_RS10430	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6I31_RS10435	COG5002	protein histidine kinase activity
I6I31_RS10440	COG0745	RESPONSE REGULATOR receiver
I6I31_RS10445	COG0538	isocitrate dehydrogenase activity
I6I31_RS10450	COG0372	Belongs to the citrate synthase family
I6I31_RS10455	COG1113	amino acid transport
I6I31_RS10460	COG0469	pyruvate kinase activity
I6I31_RS10465	COG0205	6-phosphofructokinase activity
I6I31_RS10475	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6I31_RS10480	COG0281	malic enzyme
I6I31_RS10485	COG0587	DNA-directed DNA polymerase activity
I6I31_RS10490	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6I31_RS10495	COG4109	DRTGG domain
I6I31_RS10505	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6I31_RS10510	COG0006	proline dipeptidase activity
I6I31_RS10515	COG0686	Belongs to the AlaDH PNT family
I6I31_RS10520	COG0589	response to stress
I6I31_RS10525	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6I31_RS10530	COG0827	DNA restriction-modification system
I6I31_RS10545	COG0301	tRNA thio-modification
I6I31_RS10550	COG1104	cysteine desulfurase activity
I6I31_RS10555	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I6I31_RS10560	COG1956	GAF domain-containing protein
I6I31_RS10565	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6I31_RS10570	COG0584	glycerophosphoryl diester phosphodiesterase
I6I31_RS10595	COG1263	PTS System
I6I31_RS10595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I31_RS10600	COG0204	Acyl-transferase
I6I31_RS10605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I31_RS10610	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6I31_RS10615	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I31_RS10620	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6I31_RS10630	COG0454	-acetyltransferase
I6I31_RS10640	COG1609	Transcriptional regulator
I6I31_RS10645	COG1605	Chorismate mutase
I6I31_RS10645	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I6I31_RS10655	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
I6I31_RS10660	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I31_RS10665	COG1674	ftsk spoiiie
I6I31_RS10670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I31_RS10675	COG4848	Belongs to the UPF0354 family
I6I31_RS10680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I31_RS10685	COG1363	Peptidase, m42
I6I31_RS10700	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6I31_RS10705	COG0510	thiamine kinase activity
I6I31_RS10710	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I31_RS10715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I31_RS10730	COG2244	polysaccharide biosynthetic process
I6I31_RS10735	COG2081	HI0933 family
I6I31_RS10790	COG0495	leucyl-tRNA aminoacylation
I6I31_RS10795	COG2814	Major facilitator Superfamily
I6I31_RS10800	COG1242	4 iron, 4 sulfur cluster binding
I6I31_RS10805	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6I31_RS10815	COG2267	carboxylic ester hydrolase activity
I6I31_RS10820	COG0506	proline dehydrogenase activity
I6I31_RS10825	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6I31_RS10830	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6I31_RS10830	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6I31_RS10840	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I31_RS10840	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6I31_RS10850	COG5632	N-Acetylmuramoyl-L-alanine amidase
I6I31_RS10850	COG4193	domain, Protein
I6I31_RS10850	COG3266	domain, Protein
I6I31_RS10870	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I31_RS10880	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I31_RS10885	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I31_RS10900	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6I31_RS10910	COG1506	peptidase
I6I31_RS10920	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6I31_RS10930	COG0318	PFAM AMP-dependent synthetase and ligase
I6I31_RS10970	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6I31_RS10975	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6I31_RS10980	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6I31_RS10985	COG2329	Antibiotic biosynthesis monooxygenase
I6I31_RS10995	COG4473	ABC transporter
I6I31_RS11000	COG1131	(ABC) transporter
I6I31_RS11005	COG0537	adenosine 5'-monophosphoramidase activity
I6I31_RS11020	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6I31_RS11030	COG3481	metal-dependent phosphohydrolase, HD sub domain
I6I31_RS11040	COG0420	3'-5' exonuclease activity
I6I31_RS11045	COG3679	Belongs to the UPF0342 family
I6I31_RS11060	COG2197	response regulator
I6I31_RS11070	COG0564	pseudouridine synthase activity
I6I31_RS11075	COG0114	fumarate hydratase activity
I6I31_RS11090	COG0363	glucosamine-6-phosphate deaminase activity
I6I31_RS11280	COG0735	belongs to the Fur family
I6I31_RS11285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6I31_RS11290	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6I31_RS11295	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6I31_RS11300	COG4129	membrane
I6I31_RS11310	COG3557	Belongs to the UPF0374 family
I6I31_RS11320	COG1988	membrane-bound metal-dependent
I6I31_RS11330	COG1134	teichoic acid transport
I6I31_RS11330	COG1388	LysM domain
I6I31_RS11340	COG2137	regulation of response to DNA damage stimulus
I6I31_RS11345	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I31_RS11350	COG0693	protein deglycase activity
I6I31_RS11360	COG0535	radical SAM domain protein
I6I31_RS11365	COG1607	acyl-coa hydrolase
I6I31_RS11370	COG2309	aminopeptidase activity
I6I31_RS11375	COG4840	Belongs to the UPF0435 family
I6I31_RS11380	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I31_RS11390	COG1295	ribonuclease BN
I6I31_RS11415	COG0024	Methionine aminopeptidase
I6I31_RS11420	COG4129	membrane
I6I31_RS11450	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6I31_RS11460	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I31_RS11465	COG1597	lipid kinase activity
I6I31_RS11470	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I31_RS11475	COG0154	amidase activity
I6I31_RS11480	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)