locus-tag	class	description
DV527_RS00010	COG0592	DNA-directed DNA polymerase activity
DV527_RS00015	COG2501	S4 domain
DV527_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DV527_RS00025	COG0187	DNA topoisomerase II activity
DV527_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DV527_RS00040	COG2986	histidine ammonia-lyase
DV527_RS00045	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DV527_RS00050	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DV527_RS00060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DV527_RS00070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
DV527_RS00075	COG0359	binds to the 23S rRNA
DV527_RS00080	COG0305	Participates in initiation and elongation during chromosome replication
DV527_RS00085	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DV527_RS00090	COG1819	glycosyl
DV527_RS00110	COG0477	Major facilitator Superfamily
DV527_RS00115	COG0745	RESPONSE REGULATOR receiver
DV527_RS00120	COG5002	protein histidine kinase activity
DV527_RS00125	COG4863	YycH protein
DV527_RS00135	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DV527_RS00140	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DV527_RS00190	COG0656	L-ascorbic acid biosynthetic process
DV527_RS00195	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DV527_RS00205	COG1064	alcohol dehydrogenase
DV527_RS00320	COG0697	spore germination
DV527_RS00330	COG1388	LysM domain
DV527_RS00335	COG0730	response to heat
DV527_RS00340	COG1937	Protein conserved in bacteria
DV527_RS00345	COG2210	Belongs to the sulfur carrier protein TusA family
DV527_RS00350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DV527_RS00360	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DV527_RS00365	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DV527_RS00380	COG1705	Flagellar rod assembly protein muramidase FlgJ
DV527_RS00380	COG3942	CHAP domain
DV527_RS00400	COG0640	Transcriptional regulator
DV527_RS00405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DV527_RS00410	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DV527_RS00445	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DV527_RS00450	COG0789	Transcriptional regulator
DV527_RS00460	COG0702	epimerase
DV527_RS00465	COG2130	NADP-dependent
DV527_RS00485	COG0702	epimerase
DV527_RS00490	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
DV527_RS00525	COG0415	Belongs to the DNA photolyase family
DV527_RS00540	COG1028	Short-chain dehydrogenase reductase Sdr
DV527_RS00545	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DV527_RS00550	COG2022	thiamine diphosphate biosynthetic process
DV527_RS00560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DV527_RS00570	COG1070	Carbohydrate kinase
DV527_RS00625	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DV527_RS00635	COG0579	oxidoreductase
DV527_RS00640	COG0028	Belongs to the TPP enzyme family
DV527_RS00645	COG3527	Alpha-acetolactate decarboxylase
DV527_RS00650	COG1620	l-lactate permease
DV527_RS00660	COG0583	DNA-binding transcription factor activity
DV527_RS00675	COG1136	(ABC) transporter
DV527_RS00685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DV527_RS00720	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
DV527_RS00735	COG0463	Glycosyl transferase, family 2
DV527_RS00770	COG1028	Short-chain dehydrogenase reductase Sdr
DV527_RS00780	COG1388	LysM domain
DV527_RS00785	COG1388	LysM domain
DV527_RS00805	COG1263	PTS System
DV527_RS00805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DV527_RS00805	COG2190	(PTS) system
DV527_RS00830	COG1054	Belongs to the UPF0176 family
DV527_RS00860	COG1131	(ABC) transporter
DV527_RS00885	COG1511	domain protein
DV527_RS00885	COG1511	domain protein
DV527_RS00910	COG1328	CTP reductase activity
DV527_RS00920	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DV527_RS00925	COG0346	lactoylglutathione lyase activity
DV527_RS00950	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DV527_RS00955	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DV527_RS00960	COG0579	oxidoreductase
DV527_RS01005	COG0477	Major facilitator Superfamily
DV527_RS01015	COG2814	Major facilitator Superfamily
DV527_RS01020	COG0583	DNA-binding transcription factor activity
DV527_RS01035	COG0584	glycerophosphoryl diester phosphodiesterase
DV527_RS01040	COG1846	Transcriptional regulator
DV527_RS01045	COG3961	Belongs to the TPP enzyme family
DV527_RS01065	COG0673	inositol 2-dehydrogenase activity
DV527_RS01070	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DV527_RS01075	COG1691	(AIR) carboxylase
DV527_RS01080	COG1606	tRNA processing
DV527_RS01085	COG3875	lactate racemase activity
DV527_RS01095	COG3835	regulator
DV527_RS01100	COG0574	Belongs to the PEP-utilizing enzyme family
DV527_RS01100	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DV527_RS01105	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DV527_RS01115	COG1396	sequence-specific DNA binding
DV527_RS01120	COG2807	transmembrane transport
DV527_RS01130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DV527_RS01135	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DV527_RS01140	COG1012	belongs to the aldehyde dehydrogenase family
DV527_RS01145	COG0531	amino acid
DV527_RS01170	COG1510	regulation of RNA biosynthetic process
DV527_RS01175	COG1012	belongs to the aldehyde dehydrogenase family
DV527_RS01180	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DV527_RS01190	COG0463	Glycosyl transferase, family 2
DV527_RS01190	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DV527_RS01200	COG2271	Major facilitator Superfamily
DV527_RS01205	COG0778	Nitroreductase
DV527_RS01210	COG2843	Capsule synthesis protein
DV527_RS01215	COG1957	nucleoside hydrolase
DV527_RS01220	COG0477	Major facilitator Superfamily
DV527_RS01240	COG1131	(ABC) transporter
DV527_RS01245	COG2610	gluconate transmembrane transporter activity
DV527_RS01250	COG0531	amino acid
DV527_RS01255	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DV527_RS01260	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DV527_RS01265	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DV527_RS01270	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DV527_RS01285	COG0431	NADPH-dependent FMN reductase
DV527_RS01290	COG3226	Transcriptional regulator
DV527_RS01305	COG1620	l-lactate permease
DV527_RS01310	COG2814	Major facilitator Superfamily
DV527_RS01325	COG0363	glucosamine-6-phosphate deaminase activity
DV527_RS01340	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DV527_RS01350	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DV527_RS01355	COG1447	Phosphotransferase system cellobiose-specific component IIA
DV527_RS01360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DV527_RS01365	COG0765	amino acid transport
DV527_RS01370	COG1126	abc transporter atp-binding protein
DV527_RS01375	COG3711	transcriptional antiterminator
DV527_RS01380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DV527_RS01390	COG3037	sugar-specific permease SgaT UlaA
DV527_RS01395	COG4297	protein containing double-stranded beta helix domain
DV527_RS01425	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DV527_RS01435	COG1464	Belongs to the NlpA lipoprotein family
DV527_RS01440	COG0039	L-malate dehydrogenase activity
DV527_RS01450	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DV527_RS01455	COG0626	cystathionine gamma-synthase activity
DV527_RS01460	COG2271	Major facilitator Superfamily
DV527_RS01480	COG0829	nickel cation binding
DV527_RS01485	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DV527_RS01490	COG0830	nickel cation binding
DV527_RS01495	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
DV527_RS01500	COG0804	urea catabolic process
DV527_RS01505	COG0832	Belongs to the urease beta subunit family
DV527_RS01510	COG0831	urea catabolic process
DV527_RS01515	COG4413	Urea transporter
DV527_RS01520	COG0747	negative chemotaxis
DV527_RS01545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DV527_RS01555	COG0531	amino acid
DV527_RS01565	COG0561	phosphatase activity
DV527_RS01575	COG0167	dihydroorotate dehydrogenase activity
DV527_RS01580	COG3001	Fructosamine kinase
DV527_RS01605	COG0697	spore germination
DV527_RS01610	COG1113	amino acid transport
DV527_RS01630	COG3189	MarR family transcriptional regulator
DV527_RS01645	COG1388	LysM domain
DV527_RS01650	COG0436	Aminotransferase
DV527_RS01660	COG2608	mercury ion transmembrane transporter activity
DV527_RS01665	COG2217	Heavy metal translocating P-type atpase
DV527_RS01670	COG0659	secondary active sulfate transmembrane transporter activity
DV527_RS01675	COG1136	(ABC) transporter
DV527_RS01680	COG0577	efflux transmembrane transporter activity
DV527_RS01685	COG1028	Short-chain dehydrogenase reductase Sdr
DV527_RS01700	COG0471	metal ion transport
DV527_RS01705	COG5505	Protein of unknown function (DUF819)
DV527_RS01720	COG4336	lyase activity
DV527_RS01730	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
DV527_RS01735	COG1012	belongs to the aldehyde dehydrogenase family
DV527_RS01745	COG2409	Drug exporters of the RND superfamily
DV527_RS01760	COG1473	amidohydrolase
DV527_RS01785	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DV527_RS01790	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DV527_RS01795	COG3425	synthase
DV527_RS01810	COG3386	PFAM SMP-30 Gluconolaconase
DV527_RS01815	COG3942	CHAP domain
DV527_RS01820	COG1757	Na H antiporter
DV527_RS01825	COG0583	DNA-binding transcription factor activity
DV527_RS01830	COG1380	Effector of murein hydrolase LrgA
DV527_RS01835	COG1346	cytolysis
DV527_RS01840	COG0028	Belongs to the TPP enzyme family
DV527_RS01845	COG1288	antiporter activity
DV527_RS01850	COG1263	PTS System
DV527_RS01850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DV527_RS01850	COG2190	(PTS) system
DV527_RS01860	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DV527_RS01870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DV527_RS01885	COG0697	spore germination
DV527_RS01905	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DV527_RS01915	COG2843	Capsule synthesis protein
DV527_RS01930	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DV527_RS01935	COG1063	alcohol dehydrogenase
DV527_RS01940	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DV527_RS01960	COG1129	ABC transporter
DV527_RS01985	COG1063	alcohol dehydrogenase
DV527_RS02010	COG3764	Sortase (surface protein transpeptidase)
DV527_RS02015	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
DV527_RS02020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DV527_RS02045	COG1476	TRANSCRIPTIONal
DV527_RS02050	COG2249	NAD(P)H dehydrogenase (quinone) activity
DV527_RS02055	COG0561	phosphatase activity
DV527_RS02060	COG0778	Nitroreductase
DV527_RS02065	COG2723	6-phospho-beta-galactosidase activity
DV527_RS02070	COG3711	transcriptional antiterminator
DV527_RS02075	COG2514	catechol 2,3-dioxygenase activity
DV527_RS02085	COG1132	(ABC) transporter
DV527_RS02090	COG1132	(ABC) transporter
DV527_RS02110	COG1846	Transcriptional regulator
DV527_RS02115	COG0346	lactoylglutathione lyase activity
DV527_RS02120	COG0346	lactoylglutathione lyase activity
DV527_RS02125	COG0400	carboxylic ester hydrolase activity
DV527_RS02135	COG0471	metal ion transport
DV527_RS02140	COG3949	Membrane
DV527_RS02150	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
DV527_RS02155	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DV527_RS02160	COG0586	Pfam SNARE associated Golgi protein
DV527_RS02165	COG2271	Major facilitator Superfamily
DV527_RS02175	COG1289	transmembrane transporter activity
DV527_RS02190	COG4876	unkown
DV527_RS02195	COG2357	RelA SpoT domain protein
DV527_RS02205	COG1802	Transcriptional regulator
DV527_RS02215	COG2610	gluconate transmembrane transporter activity
DV527_RS02220	COG1028	Short-chain dehydrogenase reductase Sdr
DV527_RS02225	COG3949	Membrane
DV527_RS02250	COG4221	oxidoreductase activity
DV527_RS02275	COG0107	imidazoleglycerol-phosphate synthase activity
DV527_RS02280	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DV527_RS02285	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DV527_RS02290	COG0131	Imidazoleglycerol-phosphate dehydratase
DV527_RS02300	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DV527_RS02305	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DV527_RS02310	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DV527_RS02315	COG3048	D-serine ammonia-lyase activity
DV527_RS02320	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DV527_RS02330	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DV527_RS02335	COG1028	Short-chain dehydrogenase reductase Sdr
DV527_RS02340	COG1363	Peptidase, m42
DV527_RS02350	COG0069	glutamate synthase activity
DV527_RS02360	COG4619	ABC transporter
DV527_RS02365	COG0390	transport system, permease component
DV527_RS02370	COG2814	Major facilitator Superfamily
DV527_RS02375	COG0531	amino acid
DV527_RS02380	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
DV527_RS02390	COG3246	L-lysine catabolic process to acetate
DV527_RS02395	COG1250	3-hydroxyacyl-CoA dehydrogenase
DV527_RS02410	COG1174	glycine betaine transport
DV527_RS02420	COG1174	glycine betaine transport
DV527_RS02430	COG1960	acyl-CoA dehydrogenase activity
DV527_RS02435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DV527_RS02445	COG1116	anion transmembrane transporter activity
DV527_RS02455	COG1346	cytolysis
DV527_RS02460	COG1380	Effector of murein hydrolase LrgA
DV527_RS02465	COG3279	Response regulator of the LytR AlgR family
DV527_RS02470	COG3275	phosphorelay sensor kinase activity
DV527_RS02480	COG4187	Peptidase family M20/M25/M40
DV527_RS02500	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DV527_RS02535	COG2814	Major facilitator Superfamily
DV527_RS02545	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DV527_RS02550	COG1388	LysM domain
DV527_RS02555	COG0588	phosphoglycerate mutase activity
DV527_RS02565	COG2814	Major facilitator Superfamily
DV527_RS02590	COG0803	Belongs to the bacterial solute-binding protein 9 family
DV527_RS02590	COG3443	Belongs to the bacterial solute-binding protein 9 family
DV527_RS02595	COG2353	YceI-like domain
DV527_RS02605	COG1695	Transcriptional regulator
DV527_RS02625	COG1959	2 iron, 2 sulfur cluster binding
DV527_RS02630	COG2116	formate transmembrane transporter activity
DV527_RS02635	COG0454	-acetyltransferase
DV527_RS02650	COG0071	Belongs to the small heat shock protein (HSP20) family
DV527_RS02660	COG1846	Transcriptional regulator
DV527_RS02670	COG1301	dicarboxylic acid transport
DV527_RS02680	COG2207	Transcriptional regulator
DV527_RS02690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DV527_RS02690	COG1263	PTS System
DV527_RS02710	COG1283	sodium-dependent phosphate transmembrane transporter activity
DV527_RS02715	COG1028	Short-chain dehydrogenase reductase Sdr
DV527_RS02720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DV527_RS02725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DV527_RS02730	COG1288	antiporter activity
DV527_RS02735	COG1349	DNA-binding transcription factor activity
DV527_RS02740	COG1063	alcohol dehydrogenase
DV527_RS02745	COG2376	Dihydroxyacetone kinase
DV527_RS02755	COG0698	ribose 5-phosphate isomerase
DV527_RS02765	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DV527_RS02770	COG0492	ferredoxin-NADP+ reductase activity
DV527_RS02780	COG2814	Major facilitator Superfamily
DV527_RS02785	COG0604	alcohol dehydrogenase
DV527_RS02800	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DV527_RS02800	COG0463	Glycosyl transferase, family 2
DV527_RS02805	COG1620	l-lactate permease
DV527_RS02810	COG0438	transferase activity, transferring glycosyl groups
DV527_RS02820	COG5002	protein histidine kinase activity
DV527_RS02820	COG3850	Histidine kinase
DV527_RS02825	COG0745	RESPONSE REGULATOR receiver
DV527_RS02830	COG0577	efflux transmembrane transporter activity
DV527_RS02835	COG1136	(ABC) transporter
DV527_RS02850	COG4640	response to antibiotic
DV527_RS02855	COG2814	Major facilitator Superfamily
DV527_RS02865	COG1566	PFAM secretion protein HlyD family protein
DV527_RS02870	COG2814	Major facilitator Superfamily
DV527_RS02895	COG0598	Magnesium transport protein CorA
DV527_RS02900	COG1304	FMN binding
DV527_RS02905	COG0786	glutamate:sodium symporter activity
DV527_RS02910	COG1695	Transcriptional regulator
DV527_RS02925	COG1757	Na H antiporter
DV527_RS02930	COG2094	Belongs to the DNA glycosylase MPG family
DV527_RS02935	COG3152	Membrane
DV527_RS02940	COG1069	ribulokinase activity
DV527_RS02945	COG4152	abc transporter atp-binding protein
DV527_RS02950	COG1668	transmembrane transport
DV527_RS02955	COG2017	converts alpha-aldose to the beta-anomer
DV527_RS02960	COG2258	MOSC domain
DV527_RS02965	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DV527_RS02975	COG0010	Belongs to the arginase family
DV527_RS02980	COG0583	DNA-binding transcription factor activity
DV527_RS02985	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DV527_RS02990	COG1228	amidohydrolase
DV527_RS02995	COG0659	secondary active sulfate transmembrane transporter activity
DV527_RS03000	COG1473	amidohydrolase
DV527_RS03005	COG1028	Short-chain dehydrogenase reductase Sdr
DV527_RS03010	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DV527_RS03030	COG1263	PTS System
DV527_RS03030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DV527_RS03040	COG0385	Bile acid
DV527_RS03045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DV527_RS03070	COG1113	amino acid transport
DV527_RS03075	COG1785	Belongs to the alkaline phosphatase family
DV527_RS03080	COG1737	Transcriptional regulator
DV527_RS03085	COG1263	PTS System
DV527_RS03085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DV527_RS03090	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DV527_RS03110	COG0483	inositol monophosphate 1-phosphatase activity
DV527_RS03115	COG1316	TRANSCRIPTIONal
DV527_RS03120	COG3383	formate dehydrogenase (NAD+) activity
DV527_RS03135	COG4193	domain, Protein
DV527_RS03145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DV527_RS03150	COG2076	Multidrug Resistance protein
DV527_RS03155	COG2076	Multidrug Resistance protein
DV527_RS03160	COG3942	CHAP domain
DV527_RS03175	COG1757	Na H antiporter
DV527_RS03180	COG3942	CHAP domain
DV527_RS03205	COG0765	amino acid transport
DV527_RS03210	COG0765	amino acid transport
DV527_RS03215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DV527_RS03220	COG1126	abc transporter atp-binding protein
DV527_RS03225	COG1960	acyl-CoA dehydrogenase activity
DV527_RS03230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DV527_RS03235	COG1268	BioY protein
DV527_RS03245	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DV527_RS03250	COG1609	Transcriptional regulator
DV527_RS03255	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DV527_RS03260	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DV527_RS03265	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
DV527_RS03270	COG0725	ABC transporter, periplasmic molybdate-binding protein
DV527_RS03275	COG4149	molybdate abc transporter
DV527_RS03290	COG1510	regulation of RNA biosynthetic process
DV527_RS03295	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DV527_RS03300	COG0521	Mo-molybdopterin cofactor biosynthetic process
DV527_RS03305	COG0315	cyclic pyranopterin monophosphate synthase activity
DV527_RS03330	COG0746	molybdenum cofactor guanylyltransferase activity
DV527_RS03335	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DV527_RS03365	COG2348	transferase activity, transferring amino-acyl groups
DV527_RS03370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DV527_RS03390	COG4975	Glucose uptake
DV527_RS03400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DV527_RS03400	COG0551	DNA topoisomerase type I activity
DV527_RS03405	COG2252	PERMEase
DV527_RS03415	COG0051	transcription antitermination factor activity, RNA binding
DV527_RS03420	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DV527_RS03425	COG0088	Forms part of the polypeptide exit tunnel
DV527_RS03430	COG0089	rRNA binding
DV527_RS03435	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DV527_RS03440	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DV527_RS03445	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DV527_RS03450	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DV527_RS03455	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DV527_RS03460	COG0255	Belongs to the universal ribosomal protein uL29 family
DV527_RS03465	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DV527_RS03470	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DV527_RS03475	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DV527_RS03480	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DV527_RS03485	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DV527_RS03490	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DV527_RS03495	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DV527_RS03500	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DV527_RS03505	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DV527_RS03510	COG1841	ribosomal large subunit assembly
DV527_RS03515	COG0200	Binds to the 23S rRNA
DV527_RS03520	COG0201	protein transport
DV527_RS03525	COG0563	adenylate kinase activity
DV527_RS03535	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DV527_RS03540	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DV527_RS03545	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DV527_RS03550	COG0202	RNA polymerase activity
DV527_RS03555	COG0203	ribosomal protein L17
DV527_RS03560	COG1122	ATPase activity
DV527_RS03565	COG1122	ATPase activity
DV527_RS03575	COG0101	tRNA pseudouridine synthase activity
DV527_RS03580	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DV527_RS03585	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DV527_RS03595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DV527_RS03600	COG2130	NADP-dependent
DV527_RS03605	COG0604	alcohol dehydrogenase
DV527_RS03610	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DV527_RS03625	COG1302	Protein conserved in bacteria
DV527_RS03630	COG4264	IucA IucC family
DV527_RS03635	COG2814	Major facilitator Superfamily
DV527_RS03640	COG4264	IucA IucC family
DV527_RS03645	COG3457	Alanine racemase
DV527_RS03650	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DV527_RS03655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DV527_RS03660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DV527_RS03665	COG3314	Sporulation integral membrane protein YlbJ
DV527_RS03670	COG2329	Antibiotic biosynthesis monooxygenase
DV527_RS03680	COG1988	membrane-bound metal-dependent
DV527_RS03685	COG4284	Utp--glucose-1-phosphate uridylyltransferase
DV527_RS03690	COG1272	protein, Hemolysin III
DV527_RS03705	COG0489	protein tyrosine kinase activity
DV527_RS03760	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DV527_RS03770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DV527_RS03775	COG0246	Mannitol dehydrogenase
DV527_RS03785	COG3711	transcriptional antiterminator
DV527_RS03790	COG2213	PTS system mannitol-specific
DV527_RS03805	COG1119	ATPase activity
DV527_RS03830	COG0640	Transcriptional regulator
DV527_RS03835	COG0702	epimerase
DV527_RS03840	COG2186	Transcriptional regulator
DV527_RS03845	COG1482	cell wall glycoprotein biosynthetic process
DV527_RS03855	COG2855	membrane
DV527_RS03870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DV527_RS03875	COG0783	Belongs to the Dps family
DV527_RS03880	COG0813	purine-nucleoside phosphorylase activity
DV527_RS03885	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DV527_RS03890	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DV527_RS03895	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DV527_RS03905	COG1854	S-ribosylhomocysteine lyase activity
DV527_RS03925	COG5146	pantothenate kinase activity
DV527_RS03930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DV527_RS03935	COG3343	RNA polymerase activity
DV527_RS03940	COG0504	CTP synthase activity
DV527_RS03945	COG0191	fructose-bisphosphate aldolase activity
DV527_RS03950	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DV527_RS03960	COG1012	belongs to the aldehyde dehydrogenase family
DV527_RS03965	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DV527_RS03970	COG0254	rRNA binding
DV527_RS03975	COG1435	thymidine kinase activity
DV527_RS03980	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DV527_RS03985	COG2890	protein-(glutamine-N5) methyltransferase activity
DV527_RS03990	COG0009	L-threonylcarbamoyladenylate synthase
DV527_RS03995	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DV527_RS04000	COG4475	Protein of unknown function (DUF436)
DV527_RS04005	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DV527_RS04010	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DV527_RS04015	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DV527_RS04025	COG0356	it plays a direct role in the translocation of protons across the membrane
DV527_RS04030	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DV527_RS04035	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DV527_RS04040	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DV527_RS04045	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DV527_RS04050	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DV527_RS04055	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DV527_RS04060	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DV527_RS04070	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DV527_RS04075	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DV527_RS04085	COG0629	single-stranded DNA binding
DV527_RS04090	COG1388	LysM domain
DV527_RS04095	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DV527_RS04105	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DV527_RS04110	COG0352	thiamine-phosphate diphosphorylase activity
DV527_RS04115	COG0706	membrane insertase activity
DV527_RS04120	COG1418	mRNA catabolic process
DV527_RS04130	COG1937	Protein conserved in bacteria
DV527_RS04145	COG0772	Belongs to the SEDS family
DV527_RS04150	COG1181	Belongs to the D-alanine--D-alanine ligase family
DV527_RS04155	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DV527_RS04160	COG0513	Belongs to the DEAD box helicase family
DV527_RS04170	COG3428	Bacterial PH domain
DV527_RS04175	COG3402	PFAM membrane-flanked domain
DV527_RS04180	COG0736	holo-[acyl-carrier-protein] synthase activity
DV527_RS04185	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DV527_RS04195	COG2337	Toxic component of a toxin-antitoxin (TA) module
DV527_RS04200	COG2208	phosphoserine phosphatase activity
DV527_RS04215	COG1191	sigma factor activity
DV527_RS04220	COG2183	response to ionizing radiation
DV527_RS04225	COG3091	SprT-like family
DV527_RS04255	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DV527_RS04260	COG0066	3-isopropylmalate dehydratase activity
DV527_RS04265	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DV527_RS04270	COG0473	3-isopropylmalate dehydrogenase activity
DV527_RS04275	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DV527_RS04280	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DV527_RS04285	COG0440	acetolactate synthase activity
DV527_RS04290	COG0028	Belongs to the TPP enzyme family
DV527_RS04295	COG0129	dihydroxy-acid dehydratase activity
DV527_RS04300	COG0802	atpase or kinase
DV527_RS04305	COG1214	PFAM Peptidase M22, glycoprotease
DV527_RS04310	COG0456	acetyltransferase
DV527_RS04315	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DV527_RS04325	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DV527_RS04330	COG0488	(ABC) transporter
DV527_RS04335	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DV527_RS04340	COG2391	methyltransferase activity
DV527_RS04345	COG0425	Belongs to the sulfur carrier protein TusA family
DV527_RS04350	COG1609	Transcriptional regulator
DV527_RS04355	COG1621	beta-fructofuranosidase activity
DV527_RS04360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DV527_RS04365	COG3279	Response regulator of the LytR AlgR family
DV527_RS04380	COG4512	PFAM Accessory gene regulator B
DV527_RS04385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DV527_RS04405	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DV527_RS04410	COG0459	protein refolding
DV527_RS04445	COG1725	Transcriptional regulator
DV527_RS04460	COG1131	(ABC) transporter
DV527_RS04505	COG2706	6-phosphogluconolactonase activity
DV527_RS04515	COG1012	belongs to the aldehyde dehydrogenase family
DV527_RS04520	COG1227	inorganic diphosphatase activity
DV527_RS04525	COG1335	isochorismatase
DV527_RS04535	COG0471	metal ion transport
DV527_RS04540	COG0077	Prephenate dehydratase
DV527_RS04550	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DV527_RS04555	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DV527_RS04560	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
DV527_RS04570	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DV527_RS04575	COG4496	protein, YerC YecD
DV527_RS04585	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
DV527_RS04595	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DV527_RS04600	COG4851	CamS sex pheromone cAM373 precursor
DV527_RS04605	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DV527_RS04610	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DV527_RS04615	COG0154	amidase activity
DV527_RS04620	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DV527_RS04625	COG1597	lipid kinase activity
DV527_RS04630	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DV527_RS04640	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DV527_RS04650	COG1528	Iron-storage protein
DV527_RS04665	COG4129	membrane
DV527_RS04670	COG0024	Methionine aminopeptidase
DV527_RS04685	COG4585	Histidine kinase
DV527_RS04690	COG2197	response regulator
DV527_RS04695	COG1295	ribonuclease BN
DV527_RS04705	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DV527_RS04710	COG4840	Belongs to the UPF0435 family
DV527_RS04715	COG2309	aminopeptidase activity
DV527_RS04720	COG1607	acyl-coa hydrolase
DV527_RS04725	COG0535	radical SAM domain protein
DV527_RS04735	COG0693	protein deglycase activity
DV527_RS04740	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DV527_RS04745	COG2137	regulation of response to DNA damage stimulus
DV527_RS04755	COG1134	teichoic acid transport
DV527_RS04765	COG1988	membrane-bound metal-dependent
DV527_RS04775	COG3557	Belongs to the UPF0374 family
DV527_RS04785	COG4129	membrane
DV527_RS04790	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DV527_RS04795	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DV527_RS04800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DV527_RS04805	COG0735	belongs to the Fur family
DV527_RS04950	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DV527_RS04965	COG0765	amino acid transport
DV527_RS04970	COG1126	abc transporter atp-binding protein
DV527_RS04975	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DV527_RS04985	COG0363	glucosamine-6-phosphate deaminase activity
DV527_RS05000	COG0114	fumarate hydratase activity
DV527_RS05005	COG0564	pseudouridine synthase activity
DV527_RS05010	COG2203	Gaf domain
DV527_RS05010	COG4585	Histidine kinase
DV527_RS05015	COG2197	response regulator
DV527_RS05020	COG1301	dicarboxylic acid transport
DV527_RS05035	COG1682	transport, permease protein
DV527_RS05040	COG0788	formyltetrahydrofolate deformylase activity
DV527_RS05050	COG4399	Belongs to the UPF0754 family
DV527_RS05055	COG3679	Belongs to the UPF0342 family
DV527_RS05060	COG0420	3'-5' exonuclease activity
DV527_RS05065	COG4717	serine-type aminopeptidase activity
DV527_RS05070	COG3481	metal-dependent phosphohydrolase, HD sub domain
DV527_RS05075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DV527_RS05090	COG0537	adenosine 5'-monophosphoramidase activity
DV527_RS05095	COG1131	(ABC) transporter
DV527_RS05100	COG4473	ABC transporter
DV527_RS05110	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DV527_RS05115	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DV527_RS05120	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DV527_RS05125	COG3545	Serine hydrolase
DV527_RS05175	COG2176	DNA-directed DNA polymerase activity
DV527_RS05260	COG0756	dUTP diphosphatase activity
DV527_RS05350	COG0739	heme binding
DV527_RS05385	COG1388	LysM domain
DV527_RS05385	COG0860	N-Acetylmuramoyl-L-alanine amidase
DV527_RS05415	COG0318	PFAM AMP-dependent synthetase and ligase
DV527_RS05425	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DV527_RS05435	COG1506	peptidase
DV527_RS05440	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DV527_RS05445	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DV527_RS05455	COG0656	L-ascorbic acid biosynthetic process
DV527_RS05460	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DV527_RS05465	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DV527_RS05475	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DV527_RS05505	COG5632	N-Acetylmuramoyl-L-alanine amidase
DV527_RS05505	COG4193	domain, Protein
DV527_RS05505	COG3266	domain, Protein
DV527_RS05520	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DV527_RS05520	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DV527_RS05525	COG0307	riboflavin synthase, alpha
DV527_RS05530	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DV527_RS05530	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DV527_RS05535	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DV527_RS05540	COG0506	proline dehydrogenase activity
DV527_RS05545	COG2267	carboxylic ester hydrolase activity
DV527_RS05550	COG0039	L-malate dehydrogenase activity
DV527_RS05560	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DV527_RS05565	COG1242	4 iron, 4 sulfur cluster binding
DV527_RS05570	COG2814	Major facilitator Superfamily
DV527_RS05575	COG0495	leucyl-tRNA aminoacylation
DV527_RS05585	COG2081	HI0933 family
DV527_RS05590	COG2244	polysaccharide biosynthetic process
DV527_RS05595	COG1187	pseudouridine synthase activity
DV527_RS05605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DV527_RS05610	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DV527_RS05615	COG0510	thiamine kinase activity
DV527_RS05620	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DV527_RS05625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DV527_RS05630	COG5584	Small secreted protein
DV527_RS05635	COG1363	Peptidase, m42
DV527_RS05640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DV527_RS05645	COG4848	Belongs to the UPF0354 family
DV527_RS05650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DV527_RS05655	COG1674	ftsk spoiiie
DV527_RS05660	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DV527_RS05665	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
DV527_RS05675	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DV527_RS05675	COG1605	Chorismate mutase
DV527_RS05680	COG1609	Transcriptional regulator
DV527_RS05685	COG0123	including yeast histone deacetylase and acetoin utilization protein
DV527_RS05690	COG0454	-acetyltransferase
DV527_RS05695	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DV527_RS05700	COG2759	Belongs to the formate--tetrahydrofolate ligase family
DV527_RS05705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DV527_RS05710	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DV527_RS05715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DV527_RS05720	COG0204	Acyl-transferase
DV527_RS05725	COG1263	PTS System
DV527_RS05725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DV527_RS05735	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DV527_RS05745	COG1764	response to oxidative stress
DV527_RS05750	COG0584	glycerophosphoryl diester phosphodiesterase
DV527_RS05760	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DV527_RS05770	COG1956	GAF domain-containing protein
DV527_RS05775	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
DV527_RS05780	COG1104	cysteine desulfurase activity
DV527_RS05785	COG0301	tRNA thio-modification
DV527_RS05795	COG0616	signal peptide processing
DV527_RS05800	COG1714	RDD family
DV527_RS05805	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DV527_RS05810	COG0827	DNA restriction-modification system
DV527_RS05815	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DV527_RS05825	COG0589	response to stress
DV527_RS05830	COG0686	Belongs to the AlaDH PNT family
DV527_RS05835	COG3142	Participates in the control of copper homeostasis
DV527_RS05840	COG0006	proline dipeptidase activity
DV527_RS05845	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DV527_RS05855	COG4109	DRTGG domain
DV527_RS05860	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DV527_RS05865	COG0587	DNA-directed DNA polymerase activity
DV527_RS05870	COG0281	malic enzyme
DV527_RS05875	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DV527_RS05880	COG0825	malonyl-CoA metabolic process
DV527_RS05885	COG0205	6-phosphofructokinase activity
DV527_RS05890	COG0469	pyruvate kinase activity
DV527_RS05895	COG1113	amino acid transport
DV527_RS05900	COG0372	Belongs to the citrate synthase family
DV527_RS05905	COG0538	isocitrate dehydrogenase activity
DV527_RS05910	COG0745	RESPONSE REGULATOR receiver
DV527_RS05915	COG5002	protein histidine kinase activity
DV527_RS05920	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DV527_RS05920	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DV527_RS05925	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DV527_RS05930	COG0237	dephospho-CoA kinase activity
DV527_RS05935	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DV527_RS05940	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DV527_RS05950	COG1484	DNA-dependent DNA replication
DV527_RS05955	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DV527_RS05960	COG0833	amino acid
DV527_RS05965	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DV527_RS05970	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DV527_RS05975	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DV527_RS05980	COG4112	unkown
DV527_RS05990	COG0544	peptidyl-prolyl cis-trans isomerase activity
DV527_RS05995	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DV527_RS06000	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DV527_RS06005	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DV527_RS06010	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DV527_RS06015	COG0181	hydroxymethylbilane synthase activity
DV527_RS06025	COG0113	porphobilinogen synthase activity
DV527_RS06030	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DV527_RS06045	COG2818	Glycosylase
DV527_RS06050	COG0525	valine-tRNA ligase activity
DV527_RS06055	COG0285	dihydrofolate synthase activity
DV527_RS06065	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DV527_RS06070	COG2003	Belongs to the UPF0758 family
DV527_RS06100	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DV527_RS06105	COG2868	ribosomal protein
DV527_RS06110	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DV527_RS06115	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DV527_RS06120	COG4492	Belongs to the UPF0735 family
DV527_RS06125	COG0632	four-way junction helicase activity
DV527_RS06130	COG2255	four-way junction helicase activity
DV527_RS06135	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DV527_RS06140	COG0343	queuine tRNA-ribosyltransferase activity
DV527_RS06145	COG1862	Preprotein translocase
DV527_RS06150	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DV527_RS06150	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DV527_RS06155	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DV527_RS06155	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DV527_RS06160	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DV527_RS06170	COG1490	D-aminoacyl-tRNA deacylase activity
DV527_RS06175	COG0860	N-Acetylmuramoyl-L-alanine amidase
DV527_RS06180	COG0124	histidyl-tRNA synthetase
DV527_RS06185	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DV527_RS06195	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DV527_RS06200	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DV527_RS06205	COG1959	2 iron, 2 sulfur cluster binding
DV527_RS06210	COG3237	CsbD-like
DV527_RS06215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DV527_RS06220	COG0488	(ABC) transporter
DV527_RS06225	COG1104	cysteine desulfurase activity
DV527_RS06230	COG0482	sulfurtransferase activity
DV527_RS06240	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DV527_RS06245	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DV527_RS06250	COG4472	Bacterial protein of unknown function (DUF965)
DV527_RS06255	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DV527_RS06260	COG3906	Belongs to the UPF0473 family
DV527_RS06265	COG4122	O-methyltransferase activity
DV527_RS06270	COG0826	peptidase U32
DV527_RS06275	COG0826	peptidase U32
DV527_RS06280	COG0572	uridine kinase
DV527_RS06285	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DV527_RS06290	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DV527_RS06295	COG1984	allophanate hydrolase subunit 2
DV527_RS06305	COG0439	Biotin carboxylase
DV527_RS06310	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DV527_RS06315	COG1914	H( )-stimulated, divalent metal cation uptake system
DV527_RS06320	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DV527_RS06325	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DV527_RS06330	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DV527_RS06335	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DV527_RS06340	COG1534	Rna-binding protein
DV527_RS06345	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DV527_RS06350	COG1713	HD superfamily hydrolase involved in NAD metabolism
DV527_RS06355	COG0799	negative regulation of ribosome biogenesis
DV527_RS06360	COG2226	methyltransferase
DV527_RS06365	COG1555	photosystem II stabilization
DV527_RS06365	COG1596	polysaccharide export
DV527_RS06370	COG2131	deaminase
DV527_RS06375	COG0658	competence protein
DV527_RS06375	COG2333	competence protein COMEC
DV527_RS06380	COG1466	dna polymerase III delta subunit
DV527_RS06385	COG0268	Binds directly to 16S ribosomal RNA
DV527_RS06390	COG0481	GTPase activity
DV527_RS06395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DV527_RS06400	COG1420	regulation of RNA biosynthetic process
DV527_RS06405	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DV527_RS06410	COG0443	Heat shock 70 kDa protein
DV527_RS06415	COG0484	heat shock protein binding
DV527_RS06420	COG2264	protein methyltransferase activity
DV527_RS06425	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DV527_RS06430	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DV527_RS06435	COG1030	water channel activity
DV527_RS06440	COG4864	UPF0365 protein
DV527_RS06450	COG1702	phosphate starvation-inducible protein PhoH
DV527_RS06455	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DV527_RS06465	COG0295	cytidine deaminase activity
DV527_RS06470	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DV527_RS06475	COG1381	Involved in DNA repair and RecF pathway recombination
DV527_RS06480	COG0423	glycine-tRNA ligase activity
DV527_RS06485	COG0517	IMP dehydrogenase activity
DV527_RS06490	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DV527_RS06500	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DV527_RS06505	COG2384	SAM-dependent methyltransferase
DV527_RS06510	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DV527_RS06515	COG0513	Belongs to the DEAD box helicase family
DV527_RS06520	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DV527_RS06525	COG1121	(ABC) transporter
DV527_RS06530	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DV527_RS06540	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DV527_RS06545	COG0768	penicillin binding
DV527_RS06550	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DV527_RS06555	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DV527_RS06560	COG0457	Tetratricopeptide repeat
DV527_RS06560	COG0705	Rhomboid family
DV527_RS06565	COG4483	Protein conserved in bacteria
DV527_RS06570	COG1940	carbohydrate kinase activity
DV527_RS06575	COG0011	TIGRFAM Protein of
DV527_RS06580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DV527_RS06585	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DV527_RS06590	COG1459	type II secretion system
DV527_RS06595	COG4537	Required for transformation and DNA binding
DV527_RS06620	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DV527_RS06625	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DV527_RS06630	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DV527_RS06635	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DV527_RS06640	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DV527_RS06645	COG0095	Lipoate-protein ligase
DV527_RS06660	COG0006	proline dipeptidase activity
DV527_RS06665	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DV527_RS06670	COG0511	ligase activity, forming carbon-carbon bonds
DV527_RS06675	COG0439	Biotin carboxylase
DV527_RS06680	COG1302	Protein conserved in bacteria
DV527_RS06685	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DV527_RS06690	COG1570	exodeoxyribonuclease VII activity
DV527_RS06695	COG1722	exodeoxyribonuclease VII activity
DV527_RS06710	COG1438	arginine binding
DV527_RS06715	COG0497	DNA recombination
DV527_RS06720	COG0280	phosphate acetyltransferase
DV527_RS06725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DV527_RS06730	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DV527_RS06735	COG0022	dehydrogenase e1 component
DV527_RS06740	COG0508	dehydrogenase complex catalyzes the overall conversion of
DV527_RS06750	COG4129	membrane
DV527_RS06755	COG2195	Cleaves the N-terminal amino acid of tripeptides
DV527_RS06765	COG1609	Transcriptional regulator
DV527_RS06770	COG0366	Alpha amylase catalytic
DV527_RS06780	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DV527_RS06785	COG1234	tRNA 3'-trailer cleavage
DV527_RS06790	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DV527_RS06800	COG0667	Aldo Keto reductase
DV527_RS06805	COG0494	nUDIX hydrolase
DV527_RS06810	COG0735	belongs to the Fur family
DV527_RS06815	COG4974	Belongs to the 'phage' integrase family
DV527_RS06825	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DV527_RS06830	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DV527_RS06835	COG1187	pseudouridine synthase activity
DV527_RS06840	COG0745	RESPONSE REGULATOR receiver
DV527_RS06855	COG1141	Ferredoxin
DV527_RS06865	COG0514	ATP-dependent DNA helicase (RecQ)
DV527_RS06870	COG1388	LysM domain
DV527_RS06875	COG0492	ferredoxin-NADP+ reductase activity
DV527_RS06885	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DV527_RS06890	COG0539	negative regulation of cytoplasmic translation
DV527_RS06895	COG1160	GTP binding
DV527_RS06900	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DV527_RS06915	COG2226	methyltransferase
DV527_RS06920	COG0142	geranyltranstransferase activity
DV527_RS06925	COG0105	UTP biosynthetic process
DV527_RS06930	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DV527_RS06935	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DV527_RS06940	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DV527_RS06955	COG4347	Protein of unknown function (DUF1405)
DV527_RS06960	COG2738	Putative neutral zinc metallopeptidase
DV527_RS06965	COG1694	Mazg nucleotide pyrophosphohydrolase
DV527_RS06970	COG0438	transferase activity, transferring glycosyl groups
DV527_RS06975	COG0617	tRNA 3'-terminal CCA addition
DV527_RS06980	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DV527_RS06980	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DV527_RS06985	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DV527_RS06985	COG1199	ATP-dependent helicase activity
DV527_RS06990	COG0017	Asparaginyl-tRNA synthetase
DV527_RS06995	COG3935	DnaD domain protein
DV527_RS07000	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DV527_RS07010	COG4499	WXG100 protein secretion system (Wss), protein YukC
DV527_RS07010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DV527_RS07015	COG3331	DNA recombination
DV527_RS07025	COG4474	Belongs to the UPF0398 family
DV527_RS07030	COG3599	regulation of cell shape
DV527_RS07040	COG0116	Belongs to the methyltransferase superfamily
DV527_RS07045	COG2962	Rard protein
DV527_RS07060	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DV527_RS07065	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DV527_RS07070	COG0328	RNA-DNA hybrid ribonuclease activity
DV527_RS07075	COG3545	Serine hydrolase
DV527_RS07080	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DV527_RS07090	COG1413	lyase activity
DV527_RS07095	COG1413	lyase activity
DV527_RS07105	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DV527_RS07125	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DV527_RS07135	COG4479	Belongs to the UPF0346 family
DV527_RS07140	COG0793	Belongs to the peptidase S41A family
DV527_RS07150	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DV527_RS07155	COG0671	phosphoesterase, PA-phosphatase related
DV527_RS07160	COG0745	RESPONSE REGULATOR receiver
DV527_RS07165	COG5002	protein histidine kinase activity
DV527_RS07170	COG0567	Dehydrogenase, E1 component
DV527_RS07175	COG0508	dehydrogenase complex catalyzes the overall conversion of
DV527_RS07235	COG0714	Associated with various cellular activities
DV527_RS07240	COG4548	von Willebrand factor, type A
DV527_RS07245	COG1114	Component of the transport system for branched-chain amino acids
DV527_RS07250	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DV527_RS07255	COG3853	Toxic anion resistance protein (TelA)
DV527_RS07265	COG1254	Belongs to the acylphosphatase family
DV527_RS07275	COG1278	Cold shock
DV527_RS07290	COG1473	amidohydrolase
DV527_RS07295	COG2171	N-acyltransferase activity
DV527_RS07300	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DV527_RS07305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DV527_RS07310	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DV527_RS07315	COG0527	aspartate kinase activity
DV527_RS07325	COG0488	(ABC) transporter
DV527_RS07330	COG2996	Protein conserved in bacteria
DV527_RS07335	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DV527_RS07340	COG0573	inorganic phosphate transmembrane transporter activity
DV527_RS07345	COG0581	inorganic phosphate transmembrane transporter activity
DV527_RS07350	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DV527_RS07355	COG0704	Plays a role in the regulation of phosphate uptake
DV527_RS07360	COG1164	Oligoendopeptidase f
DV527_RS07370	COG4607	ABC-type enterochelin transport system periplasmic component
DV527_RS07380	COG2348	transferase activity, transferring amino-acyl groups
DV527_RS07385	COG2348	transferase activity, transferring amino-acyl groups
DV527_RS07395	COG0159	tryptophan synthase activity
DV527_RS07400	COG0133	tryptophan synthase activity
DV527_RS07405	COG0135	phosphoribosylanthranilate isomerase activity
DV527_RS07410	COG0134	indole-3-glycerol-phosphate synthase activity
DV527_RS07415	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DV527_RS07420	COG0512	Glutamine amidotransferase of anthranilate synthase
DV527_RS07425	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DV527_RS07435	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DV527_RS07445	COG1363	Peptidase, m42
DV527_RS07460	COG0287	Prephenate dehydrogenase
DV527_RS07465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DV527_RS07470	COG1942	4-Oxalocrotonate Tautomerase
DV527_RS07485	COG1879	ABC-type sugar transport system periplasmic component
DV527_RS07490	COG1172	Belongs to the binding-protein-dependent transport system permease family
DV527_RS07495	COG1129	ABC transporter
DV527_RS07500	COG1869	D-ribose catabolic process
DV527_RS07505	COG1609	Transcriptional regulator
DV527_RS07510	COG0392	lysyltransferase activity
DV527_RS07510	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DV527_RS07515	COG0628	permease
DV527_RS07530	COG3711	transcriptional antiterminator
DV527_RS07535	COG1115	amino acid carrier protein
DV527_RS07540	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DV527_RS07550	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DV527_RS07555	COG4841	protein insertion into membrane
DV527_RS07560	COG0824	Thioesterase
DV527_RS07565	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DV527_RS07570	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DV527_RS07575	COG1970	mechanosensitive ion channel activity
DV527_RS07580	COG0419	ATPase involved in DNA repair
DV527_RS07585	COG0420	3'-5' exonuclease activity
DV527_RS07590	COG4846	Membrane protein involved in cytochrome C biogenesis
DV527_RS07605	COG3763	UPF0154 protein
DV527_RS07625	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DV527_RS07635	COG0516	GMP reductase activity
DV527_RS07640	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DV527_RS07645	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DV527_RS07650	COG0753	catalase activity
DV527_RS07655	COG0833	amino acid
DV527_RS07665	COG0561	phosphatase activity
DV527_RS07670	COG0083	homoserine kinase activity
DV527_RS07675	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DV527_RS07680	COG0460	homoserine dehydrogenase
DV527_RS07685	COG0527	aspartate kinase activity
DV527_RS07715	COG2197	response regulator
DV527_RS07720	COG4585	Histidine kinase
DV527_RS07720	COG2203	Gaf domain
DV527_RS07725	COG0842	Transport permease protein
DV527_RS07730	COG1131	(ABC) transporter
DV527_RS07745	COG0789	Transcriptional regulator
DV527_RS07750	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DV527_RS07755	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DV527_RS07760	COG0386	Belongs to the glutathione peroxidase family
DV527_RS07765	COG1923	regulation of RNA biosynthetic process
DV527_RS07770	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DV527_RS07780	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DV527_RS07785	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DV527_RS07790	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DV527_RS07805	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DV527_RS07810	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DV527_RS07820	COG4550	Control of competence regulator ComK, YlbF/YmcA
DV527_RS07825	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DV527_RS07850	COG1013	pyruvate-flavodoxin oxidoreductase activity
DV527_RS07855	COG0674	pyruvate-flavodoxin oxidoreductase activity
DV527_RS07855	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DV527_RS07860	COG1692	metallophosphoesterase
DV527_RS07870	COG1418	mRNA catabolic process
DV527_RS07875	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DV527_RS07880	COG1058	Belongs to the CinA family
DV527_RS07880	COG1546	Belongs to the CinA family
DV527_RS07900	COG0300	oxidoreductase activity
DV527_RS07905	COG0612	Peptidase, M16
DV527_RS07910	COG0612	Peptidase, M16
DV527_RS07915	COG2188	Transcriptional regulator
DV527_RS07920	COG1674	ftsk spoiiie
DV527_RS07925	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DV527_RS07930	COG1185	polyribonucleotide nucleotidyltransferase activity
DV527_RS07935	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DV527_RS07940	COG0196	riboflavin kinase activity
DV527_RS07945	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DV527_RS07950	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DV527_RS07965	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DV527_RS07970	COG1358	cellular component organization or biogenesis
DV527_RS07975	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DV527_RS07980	COG0195	Participates in both transcription termination and antitermination
DV527_RS07985	COG0779	Required for maturation of 30S ribosomal subunits
DV527_RS07990	COG2176	DNA-directed DNA polymerase activity
DV527_RS07995	COG0442	prolyl-tRNA aminoacylation
DV527_RS08005	COG4589	Belongs to the CDS family
DV527_RS08010	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DV527_RS08015	COG0233	cytoplasmic translational termination
DV527_RS08020	COG0528	UMP kinase activity
DV527_RS08025	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DV527_RS08030	COG0052	Belongs to the universal ribosomal protein uS2 family
DV527_RS08035	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DV527_RS08040	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DV527_RS08045	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DV527_RS08050	COG4974	Belongs to the 'phage' integrase family
DV527_RS08055	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DV527_RS08060	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DV527_RS08065	COG0758	DNA mediated transformation
DV527_RS08075	COG0045	succinate-CoA ligase (ADP-forming) activity
DV527_RS08080	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DV527_RS08090	COG4485	Bacterial membrane protein, YfhO
DV527_RS08100	COG0335	large ribosomal subunit rRNA binding
DV527_RS08105	COG0336	Belongs to the RNA methyltransferase TrmD family
DV527_RS08110	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DV527_RS08115	COG0228	four-way junction DNA binding
DV527_RS08120	COG1028	Short-chain dehydrogenase reductase Sdr
DV527_RS08125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DV527_RS08130	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DV527_RS08135	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DV527_RS08140	COG0552	protein localization to endoplasmic reticulum
DV527_RS08145	COG1196	nuclear chromosome segregation
DV527_RS08150	COG0571	ribonuclease III activity
DV527_RS08155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DV527_RS08170	COG0416	fatty acid biosynthetic process
DV527_RS08175	COG1349	DNA-binding transcription factor activity
DV527_RS08185	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DV527_RS08190	COG1760	l-serine dehydratase
DV527_RS08195	COG1760	l-serine dehydratase
DV527_RS08200	COG1461	Dihydroxyacetone kinase
DV527_RS08205	COG1302	Protein conserved in bacteria
DV527_RS08210	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DV527_RS08215	COG1564	THIamine pyrophosphokinase
DV527_RS08220	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DV527_RS08225	COG1162	GTPase activity
DV527_RS08235	COG0631	protein serine/threonine phosphatase activity
DV527_RS08240	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DV527_RS08245	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DV527_RS08245	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DV527_RS08250	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DV527_RS08255	COG0242	peptide deformylase activity
DV527_RS08270	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DV527_RS08275	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DV527_RS08280	COG1758	RNA polymerase activity
DV527_RS08285	COG0194	GDP metabolic process
DV527_RS08290	COG1293	RNA-binding protein homologous to eukaryotic snRNP
DV527_RS08300	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DV527_RS08310	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DV527_RS08315	COG0284	orotidine-5'-phosphate decarboxylase activity
DV527_RS08320	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DV527_RS08325	COG0505	Belongs to the CarA family
DV527_RS08335	COG0540	Belongs to the ATCase OTCase family
DV527_RS08345	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DV527_RS08350	COG0564	pseudouridine synthase activity
DV527_RS08355	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DV527_RS08365	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DV527_RS08370	COG3599	regulation of cell shape
DV527_RS08380	COG0762	integral membrane protein
DV527_RS08385	COG1799	cell septum assembly
DV527_RS08390	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DV527_RS08395	COG1496	oxidoreductase activity
DV527_RS08400	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DV527_RS08405	COG0849	cell division
DV527_RS08410	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DV527_RS08415	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DV527_RS08420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DV527_RS08425	COG0768	penicillin binding
DV527_RS08430	COG4839	cell division protein FtsL
DV527_RS08435	COG0275	rRNA processing
DV527_RS08440	COG2001	Belongs to the MraZ family
DV527_RS08445	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
DV527_RS08450	COG0454	-acetyltransferase
DV527_RS08455	COG1011	Hydrolase
DV527_RS08470	COG3271	cysteine-type peptidase activity
DV527_RS08470	COG2274	protein secretion by the type I secretion system
DV527_RS08490	COG2801	Transposase and inactivated derivatives
DV527_RS08520	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DV527_RS08525	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DV527_RS08530	COG1053	succinate dehydrogenase
DV527_RS08535	COG2009	succinate dehydrogenase
DV527_RS08540	COG0322	excinuclease ABC activity
DV527_RS08545	COG3118	belongs to the thioredoxin family
DV527_RS08550	COG1193	negative regulation of DNA recombination
DV527_RS08555	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DV527_RS08555	COG1796	DNA polymerase
DV527_RS08565	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DV527_RS08570	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DV527_RS08575	COG0072	phenylalanine-tRNA ligase activity
DV527_RS08580	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DV527_RS08585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DV527_RS08595	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DV527_RS08610	COG1323	Belongs to the UPF0348 family
DV527_RS08615	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DV527_RS08620	COG0742	ribosomal rna small subunit methyltransferase
DV527_RS08635	COG0584	glycerophosphoryl diester phosphodiesterase
DV527_RS08640	COG3679	Belongs to the UPF0342 family
DV527_RS08650	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DV527_RS08660	COG0109	protoheme IX farnesyltransferase activity
DV527_RS08665	COG1612	heme a metabolic process
DV527_RS08675	COG0772	Belongs to the SEDS family
DV527_RS08680	COG4838	Belongs to the UPF0358 family
DV527_RS08685	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DV527_RS08690	COG4896	Protein conserved in bacteria
DV527_RS08695	COG1217	gtp-binding protein TYPA
DV527_RS08705	COG0483	inositol monophosphate 1-phosphatase activity
DV527_RS08710	COG4493	Belongs to the UPF0637 family
DV527_RS08720	COG1914	H( )-stimulated, divalent metal cation uptake system
DV527_RS08735	COG1177	transmembrane transport
DV527_RS08740	COG1176	ABC-type spermidine putrescine transport system, permease component I
DV527_RS08745	COG3842	ATPase activity
DV527_RS08755	COG4476	Belongs to the UPF0223 family
DV527_RS08795	COG5503	Protein of unknown function (DUF1447)
DV527_RS08800	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DV527_RS08810	COG0569	domain protein
DV527_RS08815	COG1294	oxidase, subunit
DV527_RS08820	COG1271	oxidase subunit
DV527_RS08835	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DV527_RS08845	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DV527_RS08860	COG4172	Belongs to the ABC transporter superfamily
DV527_RS08865	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DV527_RS08870	COG0151	Belongs to the GarS family
DV527_RS08875	COG0138	bifunctional purine biosynthesis protein purh
DV527_RS08885	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DV527_RS08895	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DV527_RS08900	COG0047	phosphoribosylformylglycinamidine synthase activity
DV527_RS08905	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DV527_RS08910	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DV527_RS08915	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DV527_RS08920	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DV527_RS08925	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DV527_RS08930	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DV527_RS08930	COG1017	nitric oxide dioxygenase activity
DV527_RS08940	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DV527_RS08945	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DV527_RS08950	COG1845	cytochrome c oxidase, subunit III
DV527_RS08955	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DV527_RS08965	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DV527_RS08970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DV527_RS08975	COG1316	TRANSCRIPTIONal
DV527_RS09000	COG3594	Acyltransferase
DV527_RS09005	COG0436	Aminotransferase
DV527_RS09015	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DV527_RS09025	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DV527_RS09030	COG1169	isochorismate synthase
DV527_RS09035	COG1575	Belongs to the MenA family. Type 1 subfamily
DV527_RS09045	COG2314	TM2 domain
DV527_RS09050	COG1764	response to oxidative stress
DV527_RS09065	COG4903	ComK protein
DV527_RS09080	COG4873	Protein conserved in bacteria
DV527_RS09090	COG0737	Belongs to the 5'-nucleotidase family
DV527_RS09095	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DV527_RS09100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DV527_RS09105	COG0861	Integral membrane protein TerC family
DV527_RS09110	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DV527_RS09120	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DV527_RS09125	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DV527_RS09130	COG2814	Major facilitator Superfamily
DV527_RS09135	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DV527_RS09140	COG2382	esterase
DV527_RS09145	COG1115	amino acid carrier protein
DV527_RS09150	COG0628	permease
DV527_RS09160	COG0475	glutathione-regulated potassium exporter activity
DV527_RS09160	COG0569	domain protein
DV527_RS09165	COG2239	Acts as a magnesium transporter
DV527_RS09170	COG0564	pseudouridine synthase activity
DV527_RS09175	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DV527_RS09180	COG2357	RelA SpoT domain protein
DV527_RS09190	COG4116	CYTH
DV527_RS09195	COG2346	COG2346, Truncated hemoglobins
DV527_RS09200	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DV527_RS09205	COG2910	NAD(P)H-binding
DV527_RS09210	COG1164	Oligoendopeptidase f
DV527_RS09220	COG4862	establishment of competence for transformation
DV527_RS09225	COG1393	Belongs to the ArsC family
DV527_RS09230	COG0180	Tryptophanyl-tRNA synthetase
DV527_RS09235	COG4166	transmembrane transport
DV527_RS09240	COG4608	Belongs to the ABC transporter superfamily
DV527_RS09245	COG0444	Belongs to the ABC transporter superfamily
DV527_RS09250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DV527_RS09255	COG0601	transmembrane transport
DV527_RS09275	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DV527_RS09285	COG0542	response to heat
DV527_RS09300	COG0561	phosphatase activity
DV527_RS09305	COG0446	pyridine nucleotide-disulphide oxidoreductase
DV527_RS09315	COG0179	Fumarylacetoacetate (FAA) hydrolase
DV527_RS09320	COG2311	Membrane
DV527_RS09325	COG1074	ATP-dependent DNA helicase activity
DV527_RS09330	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DV527_RS09345	COG0398	Pfam SNARE associated Golgi protein
DV527_RS09350	COG0166	Belongs to the GPI family
DV527_RS09355	COG0137	argininosuccinate synthase activity
DV527_RS09360	COG0165	Argininosuccinate lyase
DV527_RS09365	COG0584	glycerophosphoryl diester phosphodiesterase
DV527_RS09375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DV527_RS09380	COG1902	pentaerythritol trinitrate reductase activity
DV527_RS09385	COG1098	S1 RNA binding domain
DV527_RS09390	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DV527_RS09400	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DV527_RS09400	COG2111	Na H antiporter
DV527_RS09405	COG2111	Na H antiporter
DV527_RS09410	COG1006	Multisubunit Na H antiporter MnhC subunit
DV527_RS09415	COG0651	ATP synthesis coupled electron transport
DV527_RS09420	COG1863	multisubunit Na H antiporter MnhE subunit
DV527_RS09425	COG2212	antiporter activity
DV527_RS09430	COG1320	monovalent cation:proton antiporter activity
DV527_RS09440	COG2050	protein possibly involved in aromatic compounds catabolism
DV527_RS09445	COG2056	Na+-H+ antiporter family
DV527_RS09450	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DV527_RS09455	COG1252	NADH dehydrogenase
DV527_RS09460	COG0316	Belongs to the HesB IscA family
DV527_RS09465	COG4844	belongs to the
DV527_RS09470	COG1252	NADH dehydrogenase
DV527_RS09475	COG4837	Protein of unknown function (DUF1462)
DV527_RS09480	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DV527_RS09485	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DV527_RS09490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DV527_RS09495	COG1696	Membrane protein involved in D-alanine export
DV527_RS09500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DV527_RS09515	COG0647	UMP catabolic process
DV527_RS09520	COG2445	Protein of unknown function DUF86
DV527_RS09530	COG4470	Protein conserved in bacteria
DV527_RS09535	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DV527_RS09540	COG0737	Belongs to the 5'-nucleotidase family
DV527_RS09545	COG0730	response to heat
DV527_RS09550	COG1801	Protein of unknown function DUF72
DV527_RS09555	COG2070	2-Nitropropane dioxygenase
DV527_RS09560	COG1253	flavin adenine dinucleotide binding
DV527_RS09570	COG0719	Fe-S assembly protein
DV527_RS09575	COG0822	iron-sulfur transferase activity
DV527_RS09580	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DV527_RS09585	COG0719	Fe-S assembly protein
DV527_RS09590	COG0396	ATPase activity
DV527_RS09600	COG1253	flavin adenine dinucleotide binding
DV527_RS09610	COG1464	Belongs to the NlpA lipoprotein family
DV527_RS09615	COG2011	ABC-type metal ion transport system permease component
DV527_RS09620	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DV527_RS09625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DV527_RS09630	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DV527_RS09635	COG0509	glycine decarboxylation via glycine cleavage system
DV527_RS09640	COG1393	Belongs to the ArsC family
DV527_RS09645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DV527_RS09650	COG0778	Nitroreductase
DV527_RS09655	COG0710	3-dehydroquinate dehydratase activity
DV527_RS09660	COG1764	response to oxidative stress
DV527_RS09675	COG2851	Citrate transporter
DV527_RS09690	COG2314	TM2 domain
DV527_RS09730	COG0346	lactoylglutathione lyase activity
DV527_RS09760	COG3655	Transcriptional regulator
DV527_RS09810	COG0346	lactoylglutathione lyase activity
DV527_RS09815	COG0546	phosphoglycolate phosphatase activity
DV527_RS09820	COG2259	Doxx family
DV527_RS09825	COG2153	protein acetylation
DV527_RS09885	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DV527_RS09890	COG0557	exoribonuclease II activity
DV527_RS09895	COG1647	Serine aminopeptidase, S33
DV527_RS09900	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DV527_RS09910	COG0148	phosphopyruvate hydratase activity
DV527_RS09915	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DV527_RS09920	COG0149	triose-phosphate isomerase activity
DV527_RS09925	COG0126	phosphoglycerate kinase activity
DV527_RS09950	COG1090	epimerase
DV527_RS09960	COG0740	serine-type endopeptidase activity
DV527_RS09975	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DV527_RS09980	COG1481	regulation of sporulation
DV527_RS09985	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DV527_RS09990	COG1660	Displays ATPase and GTPase activities
DV527_RS09995	COG0492	ferredoxin-NADP+ reductase activity
DV527_RS10005	COG0110	maltose O-acetyltransferase activity
DV527_RS10010	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DV527_RS10015	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DV527_RS10025	COG0556	nucleotide-excision repair
DV527_RS10040	COG1388	LysM domain
DV527_RS10040	COG3942	CHAP domain
DV527_RS10050	COG0653	protein targeting
DV527_RS10055	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DV527_RS10060	COG1040	competence protein
DV527_RS10065	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DV527_RS10075	COG1739	Uncharacterized protein family UPF0029
DV527_RS10080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DV527_RS10085	COG2199	diguanylate cyclase activity
DV527_RS10100	COG2195	Cleaves the N-terminal amino acid of tripeptides
DV527_RS10105	COG1929	Belongs to the glycerate kinase type-1 family
DV527_RS10125	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DV527_RS10140	COG4607	ABC-type enterochelin transport system periplasmic component
DV527_RS10145	COG4604	ABC transporter, ATP-binding protein
DV527_RS10150	COG4605	iron ion homeostasis
DV527_RS10155	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DV527_RS10160	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DV527_RS10165	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DV527_RS10170	COG1780	Probably involved in ribonucleotide reductase function
DV527_RS10180	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DV527_RS10185	COG3104	oligopeptide transport
DV527_RS10190	COG3104	oligopeptide transport
DV527_RS10195	COG1597	lipid kinase activity
DV527_RS10205	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DV527_RS10210	COG1174	glycine betaine transport
DV527_RS10215	COG0517	IMP dehydrogenase activity
DV527_RS10215	COG1125	glycine betaine transport
DV527_RS10220	COG0514	ATP-dependent DNA helicase (RecQ)
DV527_RS10225	COG0488	(ABC) transporter
DV527_RS10235	COG1368	sulfuric ester hydrolase activity
DV527_RS10245	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DV527_RS10260	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DV527_RS10265	COG0512	Glutamine amidotransferase of anthranilate synthase
DV527_RS10265	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DV527_RS10270	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DV527_RS10275	COG0720	synthase
DV527_RS10280	COG0602	queuosine metabolic process
DV527_RS10295	COG0463	Glycosyl transferase, family 2
DV527_RS10300	COG0656	L-ascorbic acid biosynthetic process
DV527_RS10305	COG1253	flavin adenine dinucleotide binding
DV527_RS10310	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DV527_RS10315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DV527_RS10315	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DV527_RS10315	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DV527_RS10320	COG1105	Belongs to the carbohydrate kinase PfkB family
DV527_RS10325	COG1349	DNA-binding transcription factor activity
DV527_RS10330	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DV527_RS10335	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DV527_RS10365	COG0039	L-malate dehydrogenase activity
DV527_RS10370	COG0586	Pfam SNARE associated Golgi protein
DV527_RS10380	COG4989	oxidoreductase activity
DV527_RS10395	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DV527_RS10400	COG4988	ABC transporter
DV527_RS10405	COG1968	undecaprenyl-diphosphatase activity
DV527_RS10415	COG1671	Belongs to the UPF0178 family
DV527_RS10420	COG1611	Belongs to the LOG family
DV527_RS10425	COG1279	arginine transmembrane transporter activity
DV527_RS10460	COG2814	Major facilitator Superfamily
DV527_RS10465	COG2839	Protein conserved in bacteria
DV527_RS10470	COG2814	Major facilitator Superfamily
DV527_RS10475	COG0583	DNA-binding transcription factor activity
DV527_RS10485	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DV527_RS10495	COG0217	transcriptional regulatory protein
DV527_RS10515	COG1388	LysM domain
DV527_RS10515	COG3942	CHAP domain
DV527_RS10520	COG0306	phosphate transporter
DV527_RS10525	COG1392	Phosphate transport regulator
DV527_RS10530	COG2205	protein histidine kinase activity
DV527_RS10535	COG0745	RESPONSE REGULATOR receiver
DV527_RS10540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DV527_RS10550	COG0657	acetylesterase activity
DV527_RS10555	COG3949	Membrane
DV527_RS10565	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
DV527_RS10570	COG1461	Dihydroxyacetone kinase
DV527_RS10575	COG2376	Dihydroxyacetone kinase
DV527_RS10580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DV527_RS10585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DV527_RS10590	COG1120	ATPase activity
DV527_RS10595	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DV527_RS10600	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DV527_RS10605	COG1132	(ABC) transporter
DV527_RS10615	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DV527_RS10620	COG1216	Glycosyl transferase, family 2
DV527_RS10620	COG1442	glycosyl transferase family 8
DV527_RS10625	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DV527_RS10630	COG1682	transport, permease protein
DV527_RS10635	COG1134	teichoic acid transport
DV527_RS10640	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
DV527_RS10655	COG1121	(ABC) transporter
DV527_RS10660	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DV527_RS10665	COG0803	Belongs to the bacterial solute-binding protein 9 family
DV527_RS10675	COG1320	monovalent cation:proton antiporter activity
DV527_RS10680	COG2212	antiporter activity
DV527_RS10685	COG1863	multisubunit Na H antiporter MnhE subunit
DV527_RS10690	COG0651	ATP synthesis coupled electron transport
DV527_RS10695	COG1006	Multisubunit Na H antiporter MnhC subunit
DV527_RS10700	COG2111	Na H antiporter
DV527_RS10705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DV527_RS10705	COG2111	Na H antiporter
DV527_RS10710	COG4974	Belongs to the 'phage' integrase family
DV527_RS10745	COG0596	Alpha beta hydrolase
DV527_RS10765	COG0546	phosphoglycolate phosphatase activity
DV527_RS10770	COG4139	cobalamin transport
DV527_RS10775	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DV527_RS10780	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DV527_RS10785	COG0018	arginyl-trna synthetase
DV527_RS10800	COG1078	dGTPase activity
DV527_RS10805	COG0456	acetyltransferase
DV527_RS10815	COG0667	Aldo Keto reductase
DV527_RS10820	COG4844	belongs to the
DV527_RS10840	COG0095	Lipoate-protein ligase
DV527_RS10845	COG0280	phosphate acetyltransferase
DV527_RS10850	COG3253	May function as heme-dependent peroxidase
DV527_RS10870	COG2363	Small membrane protein
DV527_RS10880	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DV527_RS10885	COG0351	phosphomethylpyrimidine kinase
DV527_RS10900	COG0534	Mate efflux family protein
DV527_RS10925	COG0183	Belongs to the thiolase family
DV527_RS10930	COG0318	PFAM AMP-dependent synthetase and ligase
DV527_RS10940	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DV527_RS10945	COG0363	glucosamine-6-phosphate deaminase activity
DV527_RS10955	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DV527_RS10960	COG1469	GTP cyclohydrolase I activity
DV527_RS10970	COG0431	NADPH-dependent FMN reductase
DV527_RS10975	COG0561	phosphatase activity
DV527_RS10985	COG1428	Deoxynucleoside kinase
DV527_RS10990	COG1428	Deoxynucleoside kinase
DV527_RS11000	COG0546	phosphoglycolate phosphatase activity
DV527_RS11020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DV527_RS11035	COG2814	Major facilitator Superfamily
DV527_RS11040	COG2824	Alkylphosphonate utilization operon protein PhnA
DV527_RS11050	COG1113	amino acid transport
DV527_RS11055	COG2040	homocysteine
DV527_RS11060	COG0833	amino acid
DV527_RS11070	COG0010	Belongs to the arginase family
DV527_RS11075	COG1914	H( )-stimulated, divalent metal cation uptake system
DV527_RS11085	COG1069	ribulokinase activity
DV527_RS11090	COG1063	alcohol dehydrogenase
DV527_RS11095	COG2814	Major facilitator Superfamily
DV527_RS11100	COG1349	DNA-binding transcription factor activity
DV527_RS11105	COG2801	Transposase and inactivated derivatives
DV527_RS11120	COG0583	DNA-binding transcription factor activity
DV527_RS11145	COG1215	transferase activity, transferring glycosyl groups
DV527_RS11145	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DV527_RS11150	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DV527_RS11150	COG1215	transferase activity, transferring glycosyl groups
DV527_RS11155	COG1216	Glycosyl transferase, family 2
DV527_RS11155	COG1442	glycosyl transferase family 8
DV527_RS11160	COG0667	Aldo Keto reductase
DV527_RS11170	COG3477	response to acidic pH
DV527_RS11185	COG1682	transport, permease protein
DV527_RS11200	COG1028	Short-chain dehydrogenase reductase Sdr
DV527_RS11205	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DV527_RS11210	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DV527_RS11240	COG1473	amidohydrolase
DV527_RS11245	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DV527_RS11250	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DV527_RS11255	COG0049	tRNA binding
DV527_RS11260	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DV527_RS11270	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DV527_RS11275	COG0085	RNA polymerase activity
DV527_RS11280	COG2813	Specifically methylates the guanine in position
DV527_RS11285	COG0222	ribosome binding
DV527_RS11290	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DV527_RS11300	COG0081	regulation of translation
DV527_RS11305	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DV527_RS11310	COG0250	Participates in transcription elongation, termination and antitermination
DV527_RS11320	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DV527_RS11335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DV527_RS11340	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
DV527_RS11345	COG0215	cysteine-tRNA ligase activity
DV527_RS11350	COG1045	serine acetyltransferase
DV527_RS11355	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DV527_RS11360	COG4956	integral membrane protein (PIN domain superfamily)
DV527_RS11365	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DV527_RS11370	COG0542	response to heat
DV527_RS11375	COG3869	Catalyzes the specific phosphorylation of arginine residues in
DV527_RS11380	COG3880	PFAM UvrB UvrC protein
DV527_RS11385	COG4463	regulation of RNA biosynthetic process
DV527_RS11390	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DV527_RS11395	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DV527_RS11400	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DV527_RS11405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DV527_RS11490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DV527_RS11495	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DV527_RS11515	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DV527_RS11520	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DV527_RS11535	COG1098	S1 RNA binding domain
DV527_RS11545	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DV527_RS11550	COG3956	TIGRFAM MazG family protein
DV527_RS11555	COG2244	polysaccharide biosynthetic process
DV527_RS11560	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DV527_RS11565	COG0193	aminoacyl-tRNA hydrolase activity
DV527_RS11570	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DV527_RS11575	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DV527_RS11580	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DV527_RS11585	COG2088	sporulation resulting in formation of a cellular spore
DV527_RS11590	COG0251	oxidation-reduction process
DV527_RS11595	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DV527_RS11600	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DV527_RS11605	COG4466	Protein conserved in bacteria
DV527_RS11610	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DV527_RS11615	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DV527_RS11620	COG0084	hydrolase, TatD family'
DV527_RS11625	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DV527_RS11625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DV527_RS11630	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DV527_RS11635	COG2827	Endonuclease containing a URI domain
DV527_RS11640	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DV527_RS11645	COG4467	Involved in initiation control of chromosome replication
DV527_RS11650	COG1774	PSP1 C-terminal conserved region
DV527_RS11655	COG0470	DNA polymerase III
DV527_RS11660	COG3870	Protein conserved in bacteria
DV527_RS11665	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DV527_RS11670	COG1982	Orn Lys Arg decarboxylase major
DV527_RS11690	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DV527_RS11695	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DV527_RS11700	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DV527_RS11715	COG2188	Transcriptional regulator
DV527_RS11720	COG0366	Alpha amylase catalytic
DV527_RS11725	COG1263	PTS System
DV527_RS11725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DV527_RS11735	COG0493	'glutamate synthase
DV527_RS11740	COG0070	glutamate synthase
DV527_RS11740	COG0067	glutamate synthase
DV527_RS11740	COG0069	glutamate synthase activity
DV527_RS11745	COG0583	DNA-binding transcription factor activity
DV527_RS11760	COG0004	ammonium transporteR
DV527_RS11775	COG1388	LysM domain
DV527_RS11775	COG3942	CHAP domain
DV527_RS11785	COG0129	dihydroxy-acid dehydratase activity
DV527_RS11800	COG0733	neurotransmitter:sodium symporter activity
DV527_RS11805	COG1114	Component of the transport system for branched-chain amino acids
DV527_RS11810	COG5646	InterPro IPR014922
DV527_RS11815	COG1647	Serine aminopeptidase, S33
DV527_RS11825	COG4195	phage-related replication protein
DV527_RS11830	COG2807	transmembrane transport
DV527_RS11835	COG0456	acetyltransferase
DV527_RS11835	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DV527_RS11840	COG2814	Major facilitator Superfamily
DV527_RS11845	COG0583	DNA-binding transcription factor activity
DV527_RS11850	COG2814	Major facilitator Superfamily
DV527_RS11875	COG1301	dicarboxylic acid transport
DV527_RS11900	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DV527_RS11900	COG0519	Catalyzes the synthesis of GMP from XMP
DV527_RS11905	COG0516	GMP reductase activity
DV527_RS11905	COG0517	IMP dehydrogenase activity
DV527_RS11910	COG2233	PERMEase
DV527_RS11915	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DV527_RS11935	COG1823	symporter activity
DV527_RS11945	COG0778	Nitroreductase
DV527_RS11950	COG3620	sequence-specific DNA binding
DV527_RS11955	COG0450	alkyl hydroperoxide reductase
DV527_RS11960	COG3634	alkyl hydroperoxide reductase activity
DV527_RS11995	COG1280	lysine exporter protein (LysE YggA)
DV527_RS12000	COG2076	Multidrug Resistance protein
DV527_RS12005	COG2076	Multidrug Resistance protein
DV527_RS12025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DV527_RS12045	COG4195	phage-related replication protein
DV527_RS12050	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DV527_RS12070	COG2808	Putative FMN-binding domain
DV527_RS12155	COG4221	oxidoreductase activity
DV527_RS12160	COG1733	regulation of RNA biosynthetic process
DV527_RS12165	COG1012	belongs to the aldehyde dehydrogenase family
DV527_RS12185	COG0753	catalase activity
DV527_RS12200	COG1063	alcohol dehydrogenase
DV527_RS12205	COG1846	Transcriptional regulator
DV527_RS12210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DV527_RS12240	COG1876	peptidase activity
DV527_RS12250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DV527_RS12260	COG1595	DNA-templated transcription, initiation
DV527_RS12265	COG4221	oxidoreductase activity
DV527_RS12290	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DV527_RS12295	COG0693	protein deglycase activity
DV527_RS12300	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DV527_RS12300	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DV527_RS12305	COG1063	alcohol dehydrogenase
DV527_RS12310	COG0697	spore germination
DV527_RS12315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DV527_RS12320	COG1733	regulation of RNA biosynthetic process
DV527_RS12325	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DV527_RS12350	COG1607	acyl-coa hydrolase
DV527_RS12355	COG0583	DNA-binding transcription factor activity
DV527_RS12370	COG0693	protein deglycase activity
DV527_RS12390	COG1028	Short-chain dehydrogenase reductase Sdr
DV527_RS12390	COG3321	synthase
DV527_RS12390	COG0604	alcohol dehydrogenase
DV527_RS12430	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DV527_RS12440	COG0360	Binds together with S18 to 16S ribosomal RNA
DV527_RS12450	COG0012	GTP binding
DV527_RS12455	COG4481	Protein conserved in bacteria
DV527_RS12460	COG0668	transmembrane transport
DV527_RS12465	COG5609	conserved protein (DUF2294)
DV527_RS12470	COG3002	Belongs to the UPF0753 family
DV527_RS12475	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DV527_RS12505	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DV527_RS12510	COG2814	Major facilitator Superfamily
DV527_RS12515	COG1473	amidohydrolase
DV527_RS12520	COG2814	Major facilitator Superfamily
DV527_RS12525	COG1733	regulation of RNA biosynthetic process
DV527_RS12530	COG3759	membrane
DV527_RS12535	COG2814	Major facilitator Superfamily
DV527_RS12560	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DV527_RS12570	COG0529	Catalyzes the synthesis of activated sulfate
DV527_RS12575	COG2046	Belongs to the sulfate adenylyltransferase family
DV527_RS12580	COG0730	response to heat
DV527_RS12600	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DV527_RS12605	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DV527_RS12610	COG0175	sulfate reduction
DV527_RS12625	COG1475	DNA binding
DV527_RS12630	COG0626	cystathionine gamma-synthase activity
DV527_RS12635	COG0626	cystathionine gamma-synthase activity
DV527_RS12640	COG0646	methionine synthase
DV527_RS12640	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DV527_RS12645	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DV527_RS12655	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DV527_RS12680	COG0183	Belongs to the thiolase family
DV527_RS12690	COG1960	acyl-CoA dehydrogenase activity
DV527_RS12695	COG0318	PFAM AMP-dependent synthetase and ligase
DV527_RS12705	COG0531	amino acid
DV527_RS12710	COG0656	L-ascorbic acid biosynthetic process
DV527_RS12750	COG1966	Carbon starvation protein
DV527_RS12755	COG1475	DNA binding
DV527_RS12760	COG0357	Ribosomal RNA small subunit methyltransferase G
DV527_RS12770	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DV527_RS12775	COG0594	ribonuclease P activity
DV527_RS12860	COG1484	DNA-dependent DNA replication
DV527_RS12945	COG1783	phage Terminase large subunit