locus-tag	class	description
AL528_RS00025	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AL528_RS00040	COG4607	ABC-type enterochelin transport system periplasmic component
AL528_RS00045	COG4604	ABC transporter, ATP-binding protein
AL528_RS00050	COG4605	iron ion homeostasis
AL528_RS00055	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL528_RS00060	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL528_RS00065	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AL528_RS00070	COG1780	Probably involved in ribonucleotide reductase function
AL528_RS00080	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AL528_RS00085	COG3104	oligopeptide transport
AL528_RS00090	COG3104	oligopeptide transport
AL528_RS00095	COG1597	lipid kinase activity
AL528_RS00105	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AL528_RS00110	COG1174	glycine betaine transport
AL528_RS00120	COG0514	ATP-dependent DNA helicase (RecQ)
AL528_RS00125	COG0488	(ABC) transporter
AL528_RS00135	COG1368	sulfuric ester hydrolase activity
AL528_RS00145	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AL528_RS00155	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL528_RS00160	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AL528_RS00160	COG0512	Glutamine amidotransferase of anthranilate synthase
AL528_RS00165	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AL528_RS00170	COG0720	synthase
AL528_RS00175	COG0602	queuosine metabolic process
AL528_RS00190	COG0463	Glycosyl transferase, family 2
AL528_RS00195	COG0656	L-ascorbic acid biosynthetic process
AL528_RS00200	COG1253	flavin adenine dinucleotide binding
AL528_RS00205	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AL528_RS00210	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL528_RS00210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL528_RS00210	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AL528_RS00215	COG1105	Belongs to the carbohydrate kinase PfkB family
AL528_RS00220	COG1349	DNA-binding transcription factor activity
AL528_RS00225	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AL528_RS00230	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AL528_RS00255	COG0039	L-malate dehydrogenase activity
AL528_RS00260	COG0586	Pfam SNARE associated Golgi protein
AL528_RS00270	COG4989	oxidoreductase activity
AL528_RS00285	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AL528_RS00290	COG4988	ABC transporter
AL528_RS00295	COG1968	undecaprenyl-diphosphatase activity
AL528_RS00305	COG1671	Belongs to the UPF0178 family
AL528_RS00310	COG1611	Belongs to the LOG family
AL528_RS00315	COG1279	arginine transmembrane transporter activity
AL528_RS00320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL528_RS00350	COG2814	Major facilitator Superfamily
AL528_RS00355	COG2839	Protein conserved in bacteria
AL528_RS00360	COG2814	Major facilitator Superfamily
AL528_RS00365	COG0583	DNA-binding transcription factor activity
AL528_RS00375	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AL528_RS00385	COG0217	transcriptional regulatory protein
AL528_RS00405	COG3942	CHAP domain
AL528_RS00405	COG1388	LysM domain
AL528_RS00410	COG0306	phosphate transporter
AL528_RS00415	COG1392	Phosphate transport regulator
AL528_RS00420	COG2205	protein histidine kinase activity
AL528_RS00425	COG0745	RESPONSE REGULATOR receiver
AL528_RS00430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL528_RS00440	COG0657	acetylesterase activity
AL528_RS00445	COG3949	Membrane
AL528_RS00455	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
AL528_RS00460	COG1461	Dihydroxyacetone kinase
AL528_RS00465	COG2376	Dihydroxyacetone kinase
AL528_RS00470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL528_RS00475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL528_RS00480	COG1120	ATPase activity
AL528_RS00485	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AL528_RS00490	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL528_RS00495	COG1132	(ABC) transporter
AL528_RS00505	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AL528_RS00510	COG1442	glycosyl transferase family 8
AL528_RS00510	COG1216	Glycosyl transferase, family 2
AL528_RS00515	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AL528_RS00520	COG1682	transport, permease protein
AL528_RS00525	COG1134	teichoic acid transport
AL528_RS00530	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AL528_RS00545	COG1121	(ABC) transporter
AL528_RS00550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL528_RS00555	COG0803	Belongs to the bacterial solute-binding protein 9 family
AL528_RS00565	COG1320	monovalent cation:proton antiporter activity
AL528_RS00570	COG2212	antiporter activity
AL528_RS00575	COG1863	multisubunit Na H antiporter MnhE subunit
AL528_RS00580	COG0651	ATP synthesis coupled electron transport
AL528_RS00585	COG1006	Multisubunit Na H antiporter MnhC subunit
AL528_RS00590	COG2111	Na H antiporter
AL528_RS00595	COG2111	Na H antiporter
AL528_RS00595	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AL528_RS00635	COG0596	Alpha beta hydrolase
AL528_RS00650	COG2267	carboxylic ester hydrolase activity
AL528_RS00655	COG0546	phosphoglycolate phosphatase activity
AL528_RS00660	COG4139	cobalamin transport
AL528_RS00665	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL528_RS00670	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AL528_RS00675	COG0018	arginyl-trna synthetase
AL528_RS00690	COG1078	dGTPase activity
AL528_RS00695	COG0456	acetyltransferase
AL528_RS00700	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AL528_RS00705	COG0667	Aldo Keto reductase
AL528_RS00710	COG4844	belongs to the
AL528_RS00730	COG0095	Lipoate-protein ligase
AL528_RS00735	COG0280	phosphate acetyltransferase
AL528_RS00740	COG3253	May function as heme-dependent peroxidase
AL528_RS00755	COG0477	Major facilitator Superfamily
AL528_RS00760	COG1846	Transcriptional regulator
AL528_RS00770	COG2363	Small membrane protein
AL528_RS00780	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AL528_RS00785	COG0351	phosphomethylpyrimidine kinase
AL528_RS00800	COG0534	Mate efflux family protein
AL528_RS00825	COG0183	Belongs to the thiolase family
AL528_RS00830	COG0318	PFAM AMP-dependent synthetase and ligase
AL528_RS00840	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AL528_RS00845	COG0363	glucosamine-6-phosphate deaminase activity
AL528_RS00855	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AL528_RS00860	COG1469	GTP cyclohydrolase I activity
AL528_RS00865	COG1846	Transcriptional regulator
AL528_RS00870	COG0431	NADPH-dependent FMN reductase
AL528_RS00875	COG0561	phosphatase activity
AL528_RS00885	COG1428	Deoxynucleoside kinase
AL528_RS00890	COG1428	Deoxynucleoside kinase
AL528_RS00900	COG0546	phosphoglycolate phosphatase activity
AL528_RS00920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AL528_RS00935	COG2814	Major facilitator Superfamily
AL528_RS00940	COG2824	Alkylphosphonate utilization operon protein PhnA
AL528_RS00950	COG1113	amino acid transport
AL528_RS00955	COG2040	homocysteine
AL528_RS00960	COG0833	amino acid
AL528_RS00970	COG0010	Belongs to the arginase family
AL528_RS00975	COG1914	H( )-stimulated, divalent metal cation uptake system
AL528_RS00985	COG1069	ribulokinase activity
AL528_RS00990	COG1063	alcohol dehydrogenase
AL528_RS00995	COG2814	Major facilitator Superfamily
AL528_RS01000	COG1349	DNA-binding transcription factor activity
AL528_RS01005	COG1132	(ABC) transporter
AL528_RS01015	COG0800	Aldolase
AL528_RS01025	COG0583	DNA-binding transcription factor activity
AL528_RS01050	COG0667	Aldo Keto reductase
AL528_RS01060	COG3477	response to acidic pH
AL528_RS01075	COG1682	transport, permease protein
AL528_RS01095	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AL528_RS01100	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AL528_RS01130	COG1473	amidohydrolase
AL528_RS01135	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AL528_RS01140	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AL528_RS01145	COG0049	tRNA binding
AL528_RS01150	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AL528_RS01160	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AL528_RS01165	COG0085	RNA polymerase activity
AL528_RS01170	COG2813	Specifically methylates the guanine in position
AL528_RS01175	COG0222	ribosome binding
AL528_RS01180	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AL528_RS01185	COG0081	regulation of translation
AL528_RS01190	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AL528_RS01195	COG0250	Participates in transcription elongation, termination and antitermination
AL528_RS01205	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AL528_RS01220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL528_RS01225	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AL528_RS01230	COG0215	cysteine-tRNA ligase activity
AL528_RS01235	COG1045	serine acetyltransferase
AL528_RS01240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AL528_RS01245	COG4956	integral membrane protein (PIN domain superfamily)
AL528_RS01250	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AL528_RS01255	COG0542	response to heat
AL528_RS01260	COG3869	Catalyzes the specific phosphorylation of arginine residues in
AL528_RS01265	COG3880	PFAM UvrB UvrC protein
AL528_RS01270	COG4463	regulation of RNA biosynthetic process
AL528_RS01275	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AL528_RS01280	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AL528_RS01285	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AL528_RS01290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL528_RS01375	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AL528_RS01380	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AL528_RS01400	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AL528_RS01405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AL528_RS01420	COG1098	S1 RNA binding domain
AL528_RS01430	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AL528_RS01435	COG3956	TIGRFAM MazG family protein
AL528_RS01440	COG2244	polysaccharide biosynthetic process
AL528_RS01445	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AL528_RS01450	COG0193	aminoacyl-tRNA hydrolase activity
AL528_RS01455	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AL528_RS01460	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AL528_RS01465	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AL528_RS01470	COG2088	sporulation resulting in formation of a cellular spore
AL528_RS01475	COG0251	oxidation-reduction process
AL528_RS01480	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AL528_RS01485	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AL528_RS01490	COG4466	Protein conserved in bacteria
AL528_RS01495	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AL528_RS01500	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AL528_RS01505	COG0084	hydrolase, TatD family'
AL528_RS01510	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL528_RS01510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL528_RS01515	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AL528_RS01520	COG2827	Endonuclease containing a URI domain
AL528_RS01525	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AL528_RS01530	COG4467	Involved in initiation control of chromosome replication
AL528_RS01535	COG1774	PSP1 C-terminal conserved region
AL528_RS01540	COG0470	DNA polymerase III
AL528_RS01545	COG3870	Protein conserved in bacteria
AL528_RS01550	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AL528_RS01555	COG1982	Orn Lys Arg decarboxylase major
AL528_RS01575	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AL528_RS01580	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AL528_RS01585	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AL528_RS01600	COG2188	Transcriptional regulator
AL528_RS01605	COG0366	Alpha amylase catalytic
AL528_RS01610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL528_RS01610	COG1263	PTS System
AL528_RS01620	COG0493	'glutamate synthase
AL528_RS01625	COG0067	glutamate synthase
AL528_RS01625	COG0069	glutamate synthase activity
AL528_RS01625	COG0070	glutamate synthase
AL528_RS01630	COG0583	DNA-binding transcription factor activity
AL528_RS01645	COG0004	ammonium transporteR
AL528_RS01650	COG0494	nUDIX hydrolase
AL528_RS01660	COG3942	CHAP domain
AL528_RS01660	COG1388	LysM domain
AL528_RS01670	COG0129	dihydroxy-acid dehydratase activity
AL528_RS01685	COG0733	neurotransmitter:sodium symporter activity
AL528_RS01690	COG1114	Component of the transport system for branched-chain amino acids
AL528_RS01695	COG5646	InterPro IPR014922
AL528_RS01720	COG2807	transmembrane transport
AL528_RS01725	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AL528_RS01725	COG0456	acetyltransferase
AL528_RS01730	COG2814	Major facilitator Superfamily
AL528_RS01735	COG0583	DNA-binding transcription factor activity
AL528_RS01740	COG2814	Major facilitator Superfamily
AL528_RS01810	COG5484	DNA packaging
AL528_RS01810	COG3728	DNA packaging
AL528_RS01870	COG0582	viral genome integration into host DNA
AL528_RS01880	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AL528_RS01880	COG0519	Catalyzes the synthesis of GMP from XMP
AL528_RS01885	COG0517	IMP dehydrogenase activity
AL528_RS01885	COG0516	GMP reductase activity
AL528_RS01890	COG2233	PERMEase
AL528_RS01895	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AL528_RS01915	COG1823	symporter activity
AL528_RS01925	COG0778	Nitroreductase
AL528_RS01930	COG3620	sequence-specific DNA binding
AL528_RS01935	COG0450	alkyl hydroperoxide reductase
AL528_RS01940	COG3634	alkyl hydroperoxide reductase activity
AL528_RS01985	COG2076	Multidrug Resistance protein
AL528_RS01995	COG1214	PFAM Peptidase M22, glycoprotease
AL528_RS01995	COG0456	acetyltransferase
AL528_RS02005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL528_RS02025	COG4195	phage-related replication protein
AL528_RS02030	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL528_RS02040	COG1522	sequence-specific DNA binding
AL528_RS02055	COG2808	Putative FMN-binding domain
AL528_RS02090	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AL528_RS02100	COG0360	Binds together with S18 to 16S ribosomal RNA
AL528_RS02110	COG0012	GTP binding
AL528_RS02115	COG4481	Protein conserved in bacteria
AL528_RS02120	COG0668	transmembrane transport
AL528_RS02125	COG5609	conserved protein (DUF2294)
AL528_RS02130	COG3002	Belongs to the UPF0753 family
AL528_RS02135	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AL528_RS02150	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AL528_RS02175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL528_RS02180	COG2814	Major facilitator Superfamily
AL528_RS02185	COG1473	amidohydrolase
AL528_RS02190	COG1473	amidohydrolase
AL528_RS02195	COG2814	Major facilitator Superfamily
AL528_RS02200	COG1733	regulation of RNA biosynthetic process
AL528_RS02205	COG3759	membrane
AL528_RS02210	COG2814	Major facilitator Superfamily
AL528_RS02235	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AL528_RS02245	COG0529	Catalyzes the synthesis of activated sulfate
AL528_RS02250	COG2046	Belongs to the sulfate adenylyltransferase family
AL528_RS02255	COG0730	response to heat
AL528_RS02275	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AL528_RS02280	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL528_RS02285	COG0175	sulfate reduction
AL528_RS02300	COG1475	DNA binding
AL528_RS02305	COG0626	cystathionine gamma-synthase activity
AL528_RS02310	COG0626	cystathionine gamma-synthase activity
AL528_RS02315	COG0646	methionine synthase
AL528_RS02315	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AL528_RS02320	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AL528_RS02330	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AL528_RS02355	COG0183	Belongs to the thiolase family
AL528_RS02365	COG1960	acyl-CoA dehydrogenase activity
AL528_RS02370	COG0318	PFAM AMP-dependent synthetase and ligase
AL528_RS02380	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL528_RS02390	COG0561	phosphatase activity
AL528_RS02395	COG0531	amino acid
AL528_RS02400	COG0656	L-ascorbic acid biosynthetic process
AL528_RS02430	COG1966	Carbon starvation protein
AL528_RS02435	COG1475	DNA binding
AL528_RS02440	COG0357	Ribosomal RNA small subunit methyltransferase G
AL528_RS02445	COG0445	tRNA wobble uridine modification
AL528_RS02450	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AL528_RS02455	COG0594	ribonuclease P activity
AL528_RS02465	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AL528_RS02470	COG0592	DNA-directed DNA polymerase activity
AL528_RS02475	COG2501	S4 domain
AL528_RS02480	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AL528_RS02485	COG0187	DNA topoisomerase II activity
AL528_RS02495	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AL528_RS02500	COG2986	histidine ammonia-lyase
AL528_RS02505	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AL528_RS02510	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AL528_RS02520	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AL528_RS02530	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AL528_RS02535	COG0359	binds to the 23S rRNA
AL528_RS02540	COG0305	Participates in initiation and elongation during chromosome replication
AL528_RS02545	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AL528_RS02550	COG1819	glycosyl
AL528_RS02570	COG0477	Major facilitator Superfamily
AL528_RS02575	COG0745	RESPONSE REGULATOR receiver
AL528_RS02580	COG5002	protein histidine kinase activity
AL528_RS02585	COG4863	YycH protein
AL528_RS02595	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AL528_RS02600	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AL528_RS02650	COG0697	spore germination
AL528_RS02660	COG1388	LysM domain
AL528_RS02665	COG0730	response to heat
AL528_RS02670	COG1937	Protein conserved in bacteria
AL528_RS02675	COG2210	Belongs to the sulfur carrier protein TusA family
AL528_RS02680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL528_RS02690	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL528_RS02695	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AL528_RS02710	COG0640	Transcriptional regulator
AL528_RS02725	COG0789	Transcriptional regulator
AL528_RS02730	COG0656	L-ascorbic acid biosynthetic process
AL528_RS02735	COG0667	Aldo Keto reductase
AL528_RS02760	COG1113	amino acid transport
AL528_RS02765	COG0753	catalase activity
AL528_RS02770	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AL528_RS02780	COG0789	Transcriptional regulator
AL528_RS02790	COG0702	epimerase
AL528_RS02795	COG2130	NADP-dependent
AL528_RS02810	COG0702	epimerase
AL528_RS02815	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
AL528_RS02850	COG0415	Belongs to the DNA photolyase family
AL528_RS02895	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AL528_RS02900	COG0579	oxidoreductase
AL528_RS02905	COG0028	Belongs to the TPP enzyme family
AL528_RS02910	COG3527	Alpha-acetolactate decarboxylase
AL528_RS02915	COG1620	l-lactate permease
AL528_RS02920	COG0583	DNA-binding transcription factor activity
AL528_RS02935	COG1136	(ABC) transporter
AL528_RS02945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL528_RS02990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL528_RS02995	COG1733	regulation of RNA biosynthetic process
AL528_RS03000	COG2207	Transcriptional regulator
AL528_RS03005	COG2211	Major facilitator Superfamily
AL528_RS03010	COG3250	beta-galactosidase activity
AL528_RS03020	COG0463	Glycosyl transferase, family 2
AL528_RS03055	COG1028	Short-chain dehydrogenase reductase Sdr
AL528_RS03065	COG1388	LysM domain
AL528_RS03070	COG1388	LysM domain
AL528_RS03075	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AL528_RS03090	COG1263	PTS System
AL528_RS03090	COG2190	(PTS) system
AL528_RS03090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL528_RS03100	COG1054	Belongs to the UPF0176 family
AL528_RS03130	COG1131	(ABC) transporter
AL528_RS03155	COG1511	domain protein
AL528_RS03155	COG1511	domain protein
AL528_RS03180	COG1328	CTP reductase activity
AL528_RS03190	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
AL528_RS03195	COG0346	lactoylglutathione lyase activity
AL528_RS03230	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AL528_RS03235	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AL528_RS03240	COG0579	oxidoreductase
AL528_RS03275	COG0477	Major facilitator Superfamily
AL528_RS03285	COG2814	Major facilitator Superfamily
AL528_RS03290	COG0583	DNA-binding transcription factor activity
AL528_RS03305	COG0584	glycerophosphoryl diester phosphodiesterase
AL528_RS03310	COG1846	Transcriptional regulator
AL528_RS03315	COG3961	Belongs to the TPP enzyme family
AL528_RS03335	COG0673	inositol 2-dehydrogenase activity
AL528_RS03340	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
AL528_RS03345	COG1691	(AIR) carboxylase
AL528_RS03350	COG1606	tRNA processing
AL528_RS03355	COG3875	lactate racemase activity
AL528_RS03365	COG3835	regulator
AL528_RS03370	COG0574	Belongs to the PEP-utilizing enzyme family
AL528_RS03370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AL528_RS03375	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AL528_RS03385	COG1396	sequence-specific DNA binding
AL528_RS03390	COG2807	transmembrane transport
AL528_RS03400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AL528_RS03405	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AL528_RS03410	COG1012	belongs to the aldehyde dehydrogenase family
AL528_RS03415	COG0531	amino acid
AL528_RS03430	COG2264	protein methyltransferase activity
AL528_RS03440	COG1510	regulation of RNA biosynthetic process
AL528_RS03445	COG1012	belongs to the aldehyde dehydrogenase family
AL528_RS03450	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AL528_RS03455	COG0583	DNA-binding transcription factor activity
AL528_RS03465	COG4221	oxidoreductase activity
AL528_RS03480	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AL528_RS03480	COG0463	Glycosyl transferase, family 2
AL528_RS03495	COG0778	Nitroreductase
AL528_RS03500	COG2843	Capsule synthesis protein
AL528_RS03505	COG1957	nucleoside hydrolase
AL528_RS03510	COG0477	Major facilitator Superfamily
AL528_RS03530	COG1131	(ABC) transporter
AL528_RS03535	COG2610	gluconate transmembrane transporter activity
AL528_RS03540	COG0531	amino acid
AL528_RS03545	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AL528_RS03550	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AL528_RS03555	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AL528_RS03560	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AL528_RS03575	COG0431	NADPH-dependent FMN reductase
AL528_RS03580	COG3226	Transcriptional regulator
AL528_RS03595	COG1620	l-lactate permease
AL528_RS03600	COG2814	Major facilitator Superfamily
AL528_RS03615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL528_RS03615	COG1263	PTS System
AL528_RS03615	COG2190	(PTS) system
AL528_RS03620	COG0363	glucosamine-6-phosphate deaminase activity
AL528_RS03635	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AL528_RS03650	COG1447	Phosphotransferase system cellobiose-specific component IIA
AL528_RS03655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL528_RS03660	COG0765	amino acid transport
AL528_RS03665	COG1126	abc transporter atp-binding protein
AL528_RS03675	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AL528_RS03685	COG1464	Belongs to the NlpA lipoprotein family
AL528_RS03690	COG0039	L-malate dehydrogenase activity
AL528_RS03695	COG1940	carbohydrate kinase activity
AL528_RS03705	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AL528_RS03710	COG0626	cystathionine gamma-synthase activity
AL528_RS03735	COG0829	nickel cation binding
AL528_RS03740	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AL528_RS03745	COG0830	nickel cation binding
AL528_RS03750	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AL528_RS03755	COG0804	urea catabolic process
AL528_RS03760	COG0832	Belongs to the urease beta subunit family
AL528_RS03765	COG0831	urea catabolic process
AL528_RS03770	COG4413	Urea transporter
AL528_RS03775	COG0747	negative chemotaxis
AL528_RS03800	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL528_RS03810	COG0531	amino acid
AL528_RS03820	COG0561	phosphatase activity
AL528_RS03830	COG0167	dihydroorotate dehydrogenase activity
AL528_RS03835	COG3001	Fructosamine kinase
AL528_RS03860	COG0697	spore germination
AL528_RS03885	COG3189	MarR family transcriptional regulator
AL528_RS03900	COG1388	LysM domain
AL528_RS03905	COG0436	Aminotransferase
AL528_RS03915	COG2608	mercury ion transmembrane transporter activity
AL528_RS03920	COG2217	Heavy metal translocating P-type atpase
AL528_RS03925	COG0659	secondary active sulfate transmembrane transporter activity
AL528_RS03930	COG1136	(ABC) transporter
AL528_RS03935	COG0577	efflux transmembrane transporter activity
AL528_RS03940	COG1028	Short-chain dehydrogenase reductase Sdr
AL528_RS03955	COG0471	metal ion transport
AL528_RS03960	COG5505	Protein of unknown function (DUF819)
AL528_RS03975	COG4336	lyase activity
AL528_RS03985	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
AL528_RS03990	COG1012	belongs to the aldehyde dehydrogenase family
AL528_RS04000	COG2409	Drug exporters of the RND superfamily
AL528_RS04015	COG1473	amidohydrolase
AL528_RS04040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AL528_RS04045	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL528_RS04050	COG3425	synthase
AL528_RS04065	COG3386	PFAM SMP-30 Gluconolaconase
AL528_RS04075	COG1757	Na H antiporter
AL528_RS04080	COG0583	DNA-binding transcription factor activity
AL528_RS04090	COG1346	cytolysis
AL528_RS04095	COG0028	Belongs to the TPP enzyme family
AL528_RS04100	COG1288	antiporter activity
AL528_RS04105	COG2190	(PTS) system
AL528_RS04105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL528_RS04105	COG1263	PTS System
AL528_RS04115	COG2515	1-aminocyclopropane-1-carboxylate deaminase
AL528_RS04125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL528_RS04150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL528_RS04160	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AL528_RS04170	COG2843	Capsule synthesis protein
AL528_RS04185	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AL528_RS04190	COG1063	alcohol dehydrogenase
AL528_RS04195	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AL528_RS04215	COG1129	ABC transporter
AL528_RS04235	COG1070	Carbohydrate kinase
AL528_RS04240	COG1063	alcohol dehydrogenase
AL528_RS04255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL528_RS04265	COG3764	Sortase (surface protein transpeptidase)
AL528_RS04270	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
AL528_RS04275	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AL528_RS04285	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL528_RS04295	COG2249	NAD(P)H dehydrogenase (quinone) activity
AL528_RS04300	COG0561	phosphatase activity
AL528_RS04305	COG0778	Nitroreductase
AL528_RS04310	COG2723	6-phospho-beta-galactosidase activity
AL528_RS04315	COG3711	transcriptional antiterminator
AL528_RS04320	COG3711	transcriptional antiterminator
AL528_RS04325	COG2514	catechol 2,3-dioxygenase activity
AL528_RS04335	COG1132	(ABC) transporter
AL528_RS04340	COG1132	(ABC) transporter
AL528_RS04360	COG1846	Transcriptional regulator
AL528_RS04365	COG0346	lactoylglutathione lyase activity
AL528_RS04370	COG0346	lactoylglutathione lyase activity
AL528_RS04375	COG0400	carboxylic ester hydrolase activity
AL528_RS04385	COG0471	metal ion transport
AL528_RS04390	COG3949	Membrane
AL528_RS04400	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
AL528_RS04405	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL528_RS04410	COG0586	Pfam SNARE associated Golgi protein
AL528_RS04415	COG2271	Major facilitator Superfamily
AL528_RS04425	COG1289	transmembrane transporter activity
AL528_RS04440	COG4876	unkown
AL528_RS04455	COG1802	Transcriptional regulator
AL528_RS04465	COG2610	gluconate transmembrane transporter activity
AL528_RS04475	COG3949	Membrane
AL528_RS04495	COG4221	oxidoreductase activity
AL528_RS04520	COG0107	imidazoleglycerol-phosphate synthase activity
AL528_RS04525	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AL528_RS04530	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AL528_RS04535	COG0131	Imidazoleglycerol-phosphate dehydratase
AL528_RS04540	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AL528_RS04545	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AL528_RS04550	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AL528_RS04555	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AL528_RS04560	COG3048	D-serine ammonia-lyase activity
AL528_RS04565	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AL528_RS04575	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
AL528_RS04580	COG1028	Short-chain dehydrogenase reductase Sdr
AL528_RS04585	COG1363	Peptidase, m42
AL528_RS04595	COG0069	glutamate synthase activity
AL528_RS04605	COG4619	ABC transporter
AL528_RS04610	COG0390	transport system, permease component
AL528_RS04615	COG2814	Major facilitator Superfamily
AL528_RS04620	COG0531	amino acid
AL528_RS04625	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
AL528_RS04635	COG3246	L-lysine catabolic process to acetate
AL528_RS04640	COG1250	3-hydroxyacyl-CoA dehydrogenase
AL528_RS04655	COG1174	glycine betaine transport
AL528_RS04665	COG1174	glycine betaine transport
AL528_RS04675	COG1960	acyl-CoA dehydrogenase activity
AL528_RS04680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AL528_RS04690	COG1116	anion transmembrane transporter activity
AL528_RS04700	COG1346	cytolysis
AL528_RS04705	COG1380	Effector of murein hydrolase LrgA
AL528_RS04710	COG3279	Response regulator of the LytR AlgR family
AL528_RS04715	COG3275	phosphorelay sensor kinase activity
AL528_RS04725	COG4187	Peptidase family M20/M25/M40
AL528_RS04745	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AL528_RS04760	COG0025	NhaP-type Na H and K H
AL528_RS04780	COG2814	Major facilitator Superfamily
AL528_RS04790	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AL528_RS04795	COG1388	LysM domain
AL528_RS04800	COG0588	phosphoglycerate mutase activity
AL528_RS04805	COG2814	Major facilitator Superfamily
AL528_RS04815	COG2801	Transposase and inactivated derivatives
AL528_RS04840	COG0803	Belongs to the bacterial solute-binding protein 9 family
AL528_RS04840	COG3443	Belongs to the bacterial solute-binding protein 9 family
AL528_RS04845	COG2353	YceI-like domain
AL528_RS04870	COG2723	6-phospho-beta-galactosidase activity
AL528_RS04875	COG1959	2 iron, 2 sulfur cluster binding
AL528_RS04880	COG2116	formate transmembrane transporter activity
AL528_RS04885	COG0454	-acetyltransferase
AL528_RS04900	COG0071	Belongs to the small heat shock protein (HSP20) family
AL528_RS04910	COG1846	Transcriptional regulator
AL528_RS04945	COG0659	secondary active sulfate transmembrane transporter activity
AL528_RS04950	COG0589	response to stress
AL528_RS04975	COG2207	Transcriptional regulator
AL528_RS04985	COG1263	PTS System
AL528_RS04985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL528_RS05005	COG1028	Short-chain dehydrogenase reductase Sdr
AL528_RS05010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL528_RS05015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL528_RS05020	COG1288	antiporter activity
AL528_RS05025	COG1349	DNA-binding transcription factor activity
AL528_RS05030	COG1063	alcohol dehydrogenase
AL528_RS05035	COG2376	Dihydroxyacetone kinase
AL528_RS05045	COG0698	ribose 5-phosphate isomerase
AL528_RS05055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL528_RS05060	COG0492	ferredoxin-NADP+ reductase activity
AL528_RS05070	COG2814	Major facilitator Superfamily
AL528_RS05075	COG0604	alcohol dehydrogenase
AL528_RS05090	COG0463	Glycosyl transferase, family 2
AL528_RS05090	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AL528_RS05095	COG1620	l-lactate permease
AL528_RS05100	COG0438	transferase activity, transferring glycosyl groups
AL528_RS05110	COG5002	protein histidine kinase activity
AL528_RS05110	COG3850	Histidine kinase
AL528_RS05115	COG0745	RESPONSE REGULATOR receiver
AL528_RS05120	COG0577	efflux transmembrane transporter activity
AL528_RS05125	COG1136	(ABC) transporter
AL528_RS05140	COG4640	response to antibiotic
AL528_RS05145	COG2814	Major facilitator Superfamily
AL528_RS05155	COG1566	PFAM secretion protein HlyD family protein
AL528_RS05160	COG2814	Major facilitator Superfamily
AL528_RS05185	COG0598	Magnesium transport protein CorA
AL528_RS05190	COG1304	FMN binding
AL528_RS05195	COG0786	glutamate:sodium symporter activity
AL528_RS05210	COG1757	Na H antiporter
AL528_RS05215	COG2094	Belongs to the DNA glycosylase MPG family
AL528_RS05220	COG3152	Membrane
AL528_RS05225	COG1069	ribulokinase activity
AL528_RS05230	COG4152	abc transporter atp-binding protein
AL528_RS05235	COG1668	transmembrane transport
AL528_RS05240	COG2017	converts alpha-aldose to the beta-anomer
AL528_RS05245	COG2258	MOSC domain
AL528_RS05250	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AL528_RS05255	COG1266	CAAX protease self-immunity
AL528_RS05260	COG0010	Belongs to the arginase family
AL528_RS05265	COG0583	DNA-binding transcription factor activity
AL528_RS05270	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AL528_RS05275	COG1228	amidohydrolase
AL528_RS05285	COG1473	amidohydrolase
AL528_RS05290	COG1028	Short-chain dehydrogenase reductase Sdr
AL528_RS05295	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AL528_RS05315	COG2801	Transposase and inactivated derivatives
AL528_RS05325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL528_RS05325	COG1263	PTS System
AL528_RS05335	COG0385	Bile acid
AL528_RS05340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AL528_RS05365	COG1113	amino acid transport
AL528_RS05370	COG1785	Belongs to the alkaline phosphatase family
AL528_RS05375	COG1737	Transcriptional regulator
AL528_RS05380	COG1263	PTS System
AL528_RS05380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL528_RS05385	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AL528_RS05405	COG0483	inositol monophosphate 1-phosphatase activity
AL528_RS05410	COG1316	TRANSCRIPTIONal
AL528_RS05415	COG3383	formate dehydrogenase (NAD+) activity
AL528_RS05430	COG4193	domain, Protein
AL528_RS05440	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL528_RS05445	COG2076	Multidrug Resistance protein
AL528_RS05450	COG2076	Multidrug Resistance protein
AL528_RS05455	COG3942	CHAP domain
AL528_RS05470	COG1757	Na H antiporter
AL528_RS05475	COG3942	CHAP domain
AL528_RS05505	COG0765	amino acid transport
AL528_RS05510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AL528_RS05515	COG1126	abc transporter atp-binding protein
AL528_RS05520	COG1960	acyl-CoA dehydrogenase activity
AL528_RS05525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL528_RS05530	COG1268	BioY protein
AL528_RS05540	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AL528_RS05545	COG1609	Transcriptional regulator
AL528_RS05550	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AL528_RS05555	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AL528_RS05560	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
AL528_RS05565	COG0725	ABC transporter, periplasmic molybdate-binding protein
AL528_RS05570	COG4149	molybdate abc transporter
AL528_RS05585	COG1510	regulation of RNA biosynthetic process
AL528_RS05590	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AL528_RS05595	COG0521	Mo-molybdopterin cofactor biosynthetic process
AL528_RS05600	COG0315	cyclic pyranopterin monophosphate synthase activity
AL528_RS05610	COG1763	Mo-molybdopterin cofactor biosynthetic process
AL528_RS05625	COG0746	molybdenum cofactor guanylyltransferase activity
AL528_RS05630	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AL528_RS05640	COG2814	Major facilitator Superfamily
AL528_RS05660	COG2348	transferase activity, transferring amino-acyl groups
AL528_RS05665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AL528_RS05685	COG4975	Glucose uptake
AL528_RS05695	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL528_RS05695	COG0551	DNA topoisomerase type I activity
AL528_RS05700	COG2252	PERMEase
AL528_RS05710	COG0051	transcription antitermination factor activity, RNA binding
AL528_RS05715	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AL528_RS05720	COG0088	Forms part of the polypeptide exit tunnel
AL528_RS05725	COG0089	rRNA binding
AL528_RS05730	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AL528_RS05735	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AL528_RS05740	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AL528_RS05745	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AL528_RS05750	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AL528_RS05755	COG0255	Belongs to the universal ribosomal protein uL29 family
AL528_RS05760	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AL528_RS05765	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AL528_RS05770	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AL528_RS05775	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AL528_RS05780	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AL528_RS05785	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AL528_RS05790	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AL528_RS05795	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AL528_RS05800	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AL528_RS05805	COG1841	ribosomal large subunit assembly
AL528_RS05810	COG0200	Binds to the 23S rRNA
AL528_RS05815	COG0201	protein transport
AL528_RS05820	COG0563	adenylate kinase activity
AL528_RS05830	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AL528_RS05835	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AL528_RS05840	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AL528_RS05845	COG0202	RNA polymerase activity
AL528_RS05850	COG0203	ribosomal protein L17
AL528_RS05855	COG1122	ATPase activity
AL528_RS05860	COG1122	ATPase activity
AL528_RS05870	COG0101	tRNA pseudouridine synthase activity
AL528_RS05875	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AL528_RS05880	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AL528_RS05890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL528_RS05895	COG2130	NADP-dependent
AL528_RS05900	COG0604	alcohol dehydrogenase
AL528_RS05905	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL528_RS05920	COG1302	Protein conserved in bacteria
AL528_RS05925	COG4264	IucA IucC family
AL528_RS05930	COG2814	Major facilitator Superfamily
AL528_RS05935	COG4264	IucA IucC family
AL528_RS05940	COG3457	Alanine racemase
AL528_RS05945	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AL528_RS05950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL528_RS05955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AL528_RS05960	COG3314	Sporulation integral membrane protein YlbJ
AL528_RS05965	COG2329	Antibiotic biosynthesis monooxygenase
AL528_RS05975	COG1988	membrane-bound metal-dependent
AL528_RS05980	COG4284	Utp--glucose-1-phosphate uridylyltransferase
AL528_RS05985	COG1272	protein, Hemolysin III
AL528_RS06000	COG0489	protein tyrosine kinase activity
AL528_RS06055	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AL528_RS06065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL528_RS06070	COG0246	Mannitol dehydrogenase
AL528_RS06080	COG3711	transcriptional antiterminator
AL528_RS06085	COG2213	PTS system mannitol-specific
AL528_RS06100	COG1119	ATPase activity
AL528_RS06125	COG0640	Transcriptional regulator
AL528_RS06130	COG0702	epimerase
AL528_RS06135	COG2186	Transcriptional regulator
AL528_RS06140	COG1482	cell wall glycoprotein biosynthetic process
AL528_RS06150	COG2855	membrane
AL528_RS06165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL528_RS06170	COG0783	Belongs to the Dps family
AL528_RS06175	COG0813	purine-nucleoside phosphorylase activity
AL528_RS06180	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AL528_RS06185	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AL528_RS06190	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AL528_RS06200	COG1854	S-ribosylhomocysteine lyase activity
AL528_RS06220	COG5146	pantothenate kinase activity
AL528_RS06225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AL528_RS06230	COG3343	RNA polymerase activity
AL528_RS06235	COG0504	CTP synthase activity
AL528_RS06240	COG0191	fructose-bisphosphate aldolase activity
AL528_RS06245	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AL528_RS06255	COG1012	belongs to the aldehyde dehydrogenase family
AL528_RS06260	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AL528_RS06265	COG0254	rRNA binding
AL528_RS06270	COG1435	thymidine kinase activity
AL528_RS06275	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AL528_RS06280	COG2890	protein-(glutamine-N5) methyltransferase activity
AL528_RS06285	COG0009	L-threonylcarbamoyladenylate synthase
AL528_RS06290	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL528_RS06295	COG4475	Protein of unknown function (DUF436)
AL528_RS06300	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AL528_RS06305	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AL528_RS06310	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AL528_RS06320	COG0356	it plays a direct role in the translocation of protons across the membrane
AL528_RS06325	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AL528_RS06330	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AL528_RS06335	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AL528_RS06340	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AL528_RS06345	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AL528_RS06350	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AL528_RS06355	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AL528_RS06365	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AL528_RS06370	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AL528_RS06380	COG0629	single-stranded DNA binding
AL528_RS06385	COG1388	LysM domain
AL528_RS06390	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AL528_RS06400	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AL528_RS06405	COG0352	thiamine-phosphate diphosphorylase activity
AL528_RS06410	COG0706	membrane insertase activity
AL528_RS06415	COG1418	mRNA catabolic process
AL528_RS06425	COG1937	Protein conserved in bacteria
AL528_RS06435	COG0772	Belongs to the SEDS family
AL528_RS06440	COG1181	Belongs to the D-alanine--D-alanine ligase family
AL528_RS06445	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AL528_RS06450	COG0513	Belongs to the DEAD box helicase family
AL528_RS06460	COG3428	Bacterial PH domain
AL528_RS06465	COG3402	PFAM membrane-flanked domain
AL528_RS06470	COG0736	holo-[acyl-carrier-protein] synthase activity
AL528_RS06475	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AL528_RS06485	COG2337	Toxic component of a toxin-antitoxin (TA) module
AL528_RS06490	COG2208	phosphoserine phosphatase activity
AL528_RS06505	COG1191	sigma factor activity
AL528_RS06510	COG2183	response to ionizing radiation
AL528_RS06515	COG3091	SprT-like family
AL528_RS06550	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AL528_RS06555	COG0066	3-isopropylmalate dehydratase activity
AL528_RS06560	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AL528_RS06565	COG0473	3-isopropylmalate dehydrogenase activity
AL528_RS06570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AL528_RS06575	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AL528_RS06580	COG0440	acetolactate synthase activity
AL528_RS06585	COG0028	Belongs to the TPP enzyme family
AL528_RS06590	COG0129	dihydroxy-acid dehydratase activity
AL528_RS06595	COG0802	atpase or kinase
AL528_RS06600	COG1214	PFAM Peptidase M22, glycoprotease
AL528_RS06605	COG0456	acetyltransferase
AL528_RS06610	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AL528_RS06620	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AL528_RS06625	COG0488	(ABC) transporter
AL528_RS06630	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AL528_RS06635	COG2391	methyltransferase activity
AL528_RS06640	COG0425	Belongs to the sulfur carrier protein TusA family
AL528_RS06645	COG1609	Transcriptional regulator
AL528_RS06650	COG1621	beta-fructofuranosidase activity
AL528_RS06655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AL528_RS06660	COG3279	Response regulator of the LytR AlgR family
AL528_RS06665	COG3290	protein histidine kinase activity
AL528_RS06675	COG4512	PFAM Accessory gene regulator B
AL528_RS06680	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AL528_RS06700	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AL528_RS06705	COG0459	protein refolding
AL528_RS06740	COG1725	Transcriptional regulator
AL528_RS06745	COG0842	Transport permease protein
AL528_RS06745	COG1129	ABC transporter
AL528_RS06760	COG1131	(ABC) transporter
AL528_RS06800	COG2706	6-phosphogluconolactonase activity
AL528_RS06805	COG1012	belongs to the aldehyde dehydrogenase family
AL528_RS06810	COG1227	inorganic diphosphatase activity
AL528_RS06815	COG1335	isochorismatase
AL528_RS06825	COG0471	metal ion transport
AL528_RS06830	COG0077	Prephenate dehydratase
AL528_RS06840	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AL528_RS06845	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AL528_RS06850	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
AL528_RS06860	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AL528_RS06865	COG4496	protein, YerC YecD
AL528_RS06875	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
AL528_RS06885	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AL528_RS06890	COG4851	CamS sex pheromone cAM373 precursor
AL528_RS06895	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AL528_RS06900	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AL528_RS06905	COG0154	amidase activity
AL528_RS06910	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AL528_RS06915	COG1597	lipid kinase activity
AL528_RS06920	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AL528_RS06930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AL528_RS06940	COG1528	Iron-storage protein
AL528_RS06960	COG2801	Transposase and inactivated derivatives
AL528_RS06965	COG4129	membrane
AL528_RS06970	COG0024	Methionine aminopeptidase
AL528_RS06985	COG4585	Histidine kinase
AL528_RS06990	COG2197	response regulator
AL528_RS06995	COG1295	ribonuclease BN
AL528_RS07005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AL528_RS07010	COG4840	Belongs to the UPF0435 family
AL528_RS07015	COG2309	aminopeptidase activity
AL528_RS07020	COG1607	acyl-coa hydrolase
AL528_RS07025	COG0535	radical SAM domain protein
AL528_RS07030	COG0693	protein deglycase activity
AL528_RS07035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL528_RS07040	COG2137	regulation of response to DNA damage stimulus
AL528_RS07050	COG1134	teichoic acid transport
AL528_RS07060	COG1988	membrane-bound metal-dependent
AL528_RS07070	COG3557	Belongs to the UPF0374 family
AL528_RS07080	COG4129	membrane
AL528_RS07085	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AL528_RS07090	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AL528_RS07095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AL528_RS07100	COG0735	belongs to the Fur family
AL528_RS07245	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AL528_RS07260	COG0765	amino acid transport
AL528_RS07265	COG1126	abc transporter atp-binding protein
AL528_RS07270	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AL528_RS07280	COG0363	glucosamine-6-phosphate deaminase activity
AL528_RS07295	COG0114	fumarate hydratase activity
AL528_RS07300	COG0564	pseudouridine synthase activity
AL528_RS07305	COG2203	Gaf domain
AL528_RS07305	COG4585	Histidine kinase
AL528_RS07310	COG2197	response regulator
AL528_RS07315	COG1301	dicarboxylic acid transport
AL528_RS07330	COG1682	transport, permease protein
AL528_RS07335	COG0788	formyltetrahydrofolate deformylase activity
AL528_RS07345	COG4399	Belongs to the UPF0754 family
AL528_RS07350	COG3679	Belongs to the UPF0342 family
AL528_RS07355	COG0420	3'-5' exonuclease activity
AL528_RS07360	COG4717	serine-type aminopeptidase activity
AL528_RS07365	COG3481	metal-dependent phosphohydrolase, HD sub domain
AL528_RS07370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AL528_RS07385	COG0537	adenosine 5'-monophosphoramidase activity
AL528_RS07390	COG1131	(ABC) transporter
AL528_RS07395	COG4473	ABC transporter
AL528_RS07405	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AL528_RS07410	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AL528_RS07415	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AL528_RS07420	COG3545	Serine hydrolase
AL528_RS07525	COG0629	single-stranded DNA binding
AL528_RS07545	COG0305	Participates in initiation and elongation during chromosome replication
AL528_RS07755	COG5434	Belongs to the glycosyl hydrolase 28 family
AL528_RS07795	COG0860	N-Acetylmuramoyl-L-alanine amidase
AL528_RS07795	COG1388	LysM domain
AL528_RS07805	COG0318	PFAM AMP-dependent synthetase and ligase
AL528_RS07815	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AL528_RS07825	COG1506	peptidase
AL528_RS07830	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AL528_RS07835	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AL528_RS07845	COG0656	L-ascorbic acid biosynthetic process
AL528_RS07850	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AL528_RS07855	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AL528_RS07865	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AL528_RS07895	COG5632	N-Acetylmuramoyl-L-alanine amidase
AL528_RS07895	COG3266	domain, Protein
AL528_RS07895	COG4193	domain, Protein
AL528_RS07920	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL528_RS07920	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AL528_RS07925	COG0307	riboflavin synthase, alpha
AL528_RS07930	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL528_RS07930	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AL528_RS07935	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AL528_RS07945	COG2267	carboxylic ester hydrolase activity
AL528_RS07950	COG0039	L-malate dehydrogenase activity
AL528_RS07960	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AL528_RS07965	COG1242	4 iron, 4 sulfur cluster binding
AL528_RS07970	COG2814	Major facilitator Superfamily
AL528_RS07975	COG0495	leucyl-tRNA aminoacylation
AL528_RS07985	COG2081	HI0933 family
AL528_RS07990	COG2244	polysaccharide biosynthetic process
AL528_RS07995	COG1187	pseudouridine synthase activity
AL528_RS08005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AL528_RS08010	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AL528_RS08015	COG0510	thiamine kinase activity
AL528_RS08020	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AL528_RS08025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL528_RS08030	COG5584	Small secreted protein
AL528_RS08035	COG1363	Peptidase, m42
AL528_RS08040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL528_RS08045	COG4848	Belongs to the UPF0354 family
AL528_RS08050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AL528_RS08055	COG1674	ftsk spoiiie
AL528_RS08060	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AL528_RS08065	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
AL528_RS08075	COG1605	Chorismate mutase
AL528_RS08075	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AL528_RS08080	COG1609	Transcriptional regulator
AL528_RS08085	COG0123	including yeast histone deacetylase and acetoin utilization protein
AL528_RS08090	COG0454	-acetyltransferase
AL528_RS08095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AL528_RS08105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL528_RS08110	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AL528_RS08115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL528_RS08120	COG0204	Acyl-transferase
AL528_RS08125	COG1263	PTS System
AL528_RS08125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AL528_RS08135	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AL528_RS08145	COG1764	response to oxidative stress
AL528_RS08150	COG0584	glycerophosphoryl diester phosphodiesterase
AL528_RS08160	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AL528_RS08165	COG1956	GAF domain-containing protein
AL528_RS08170	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
AL528_RS08175	COG1104	cysteine desulfurase activity
AL528_RS08180	COG0301	tRNA thio-modification
AL528_RS08190	COG0616	signal peptide processing
AL528_RS08195	COG1714	RDD family
AL528_RS08200	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AL528_RS08205	COG0827	DNA restriction-modification system
AL528_RS08210	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AL528_RS08220	COG0589	response to stress
AL528_RS08225	COG0686	Belongs to the AlaDH PNT family
AL528_RS08230	COG3142	Participates in the control of copper homeostasis
AL528_RS08235	COG0006	proline dipeptidase activity
AL528_RS08240	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AL528_RS08250	COG4109	DRTGG domain
AL528_RS08255	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AL528_RS08260	COG0587	DNA-directed DNA polymerase activity
AL528_RS08265	COG0281	malic enzyme
AL528_RS08270	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AL528_RS08275	COG0825	malonyl-CoA metabolic process
AL528_RS08280	COG0205	6-phosphofructokinase activity
AL528_RS08285	COG0469	pyruvate kinase activity
AL528_RS08290	COG1113	amino acid transport
AL528_RS08295	COG0372	Belongs to the citrate synthase family
AL528_RS08300	COG0538	isocitrate dehydrogenase activity
AL528_RS08305	COG0745	RESPONSE REGULATOR receiver
AL528_RS08310	COG5002	protein histidine kinase activity
AL528_RS08315	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL528_RS08315	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL528_RS08320	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AL528_RS08325	COG0237	dephospho-CoA kinase activity
AL528_RS08330	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AL528_RS08335	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AL528_RS08345	COG1484	DNA-dependent DNA replication
AL528_RS08350	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AL528_RS08355	COG0833	amino acid
AL528_RS08360	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AL528_RS08365	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AL528_RS08370	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AL528_RS08375	COG4112	unkown
AL528_RS08385	COG0544	peptidyl-prolyl cis-trans isomerase activity
AL528_RS08390	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AL528_RS08395	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AL528_RS08400	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AL528_RS08405	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AL528_RS08410	COG0181	hydroxymethylbilane synthase activity
AL528_RS08420	COG0113	porphobilinogen synthase activity
AL528_RS08425	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AL528_RS08440	COG2818	Glycosylase
AL528_RS08445	COG0525	valine-tRNA ligase activity
AL528_RS08450	COG0285	dihydrofolate synthase activity
AL528_RS08460	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AL528_RS08465	COG2003	Belongs to the UPF0758 family
AL528_RS08490	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AL528_RS08495	COG2868	ribosomal protein
AL528_RS08500	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AL528_RS08505	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AL528_RS08510	COG4492	Belongs to the UPF0735 family
AL528_RS08515	COG0632	four-way junction helicase activity
AL528_RS08520	COG2255	four-way junction helicase activity
AL528_RS08525	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AL528_RS08530	COG0343	queuine tRNA-ribosyltransferase activity
AL528_RS08535	COG1862	Preprotein translocase
AL528_RS08540	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL528_RS08540	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AL528_RS08545	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AL528_RS08545	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AL528_RS08550	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AL528_RS08560	COG1490	D-aminoacyl-tRNA deacylase activity
AL528_RS08565	COG0860	N-Acetylmuramoyl-L-alanine amidase
AL528_RS08570	COG0124	histidyl-tRNA synthetase
AL528_RS08575	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AL528_RS08585	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AL528_RS08590	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AL528_RS08595	COG1959	2 iron, 2 sulfur cluster binding
AL528_RS08600	COG3237	CsbD-like
AL528_RS08605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL528_RS08610	COG1132	(ABC) transporter
AL528_RS08615	COG0488	(ABC) transporter
AL528_RS08620	COG1104	cysteine desulfurase activity
AL528_RS08625	COG0482	sulfurtransferase activity
AL528_RS08635	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AL528_RS08640	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AL528_RS08645	COG4472	Bacterial protein of unknown function (DUF965)
AL528_RS08650	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AL528_RS08655	COG3906	Belongs to the UPF0473 family
AL528_RS08660	COG4122	O-methyltransferase activity
AL528_RS08665	COG0826	peptidase U32
AL528_RS08670	COG0826	peptidase U32
AL528_RS08675	COG0572	uridine kinase
AL528_RS08680	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AL528_RS08685	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AL528_RS08690	COG1984	allophanate hydrolase subunit 2
AL528_RS08700	COG0439	Biotin carboxylase
AL528_RS08705	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AL528_RS08710	COG1914	H( )-stimulated, divalent metal cation uptake system
AL528_RS08715	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AL528_RS08720	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AL528_RS08725	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AL528_RS08730	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AL528_RS08735	COG1534	Rna-binding protein
AL528_RS08740	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AL528_RS08745	COG1713	HD superfamily hydrolase involved in NAD metabolism
AL528_RS08750	COG0799	negative regulation of ribosome biogenesis
AL528_RS08755	COG2226	methyltransferase
AL528_RS08760	COG1596	polysaccharide export
AL528_RS08760	COG1555	photosystem II stabilization
AL528_RS08765	COG2131	deaminase
AL528_RS08770	COG0658	competence protein
AL528_RS08770	COG2333	competence protein COMEC
AL528_RS08775	COG1466	dna polymerase III delta subunit
AL528_RS08780	COG0268	Binds directly to 16S ribosomal RNA
AL528_RS08785	COG0481	GTPase activity
AL528_RS08790	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AL528_RS08795	COG1420	regulation of RNA biosynthetic process
AL528_RS08800	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AL528_RS08805	COG0443	Heat shock 70 kDa protein
AL528_RS08810	COG0484	heat shock protein binding
AL528_RS08815	COG2264	protein methyltransferase activity
AL528_RS08820	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AL528_RS08825	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AL528_RS08830	COG1030	water channel activity
AL528_RS08835	COG4864	UPF0365 protein
AL528_RS08845	COG1702	phosphate starvation-inducible protein PhoH
AL528_RS08850	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AL528_RS08860	COG0295	cytidine deaminase activity
AL528_RS08865	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AL528_RS08870	COG1381	Involved in DNA repair and RecF pathway recombination
AL528_RS08875	COG0423	glycine-tRNA ligase activity
AL528_RS08880	COG0517	IMP dehydrogenase activity
AL528_RS08885	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AL528_RS08895	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AL528_RS08900	COG2384	SAM-dependent methyltransferase
AL528_RS08905	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AL528_RS08910	COG0513	Belongs to the DEAD box helicase family
AL528_RS08915	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AL528_RS08920	COG1121	(ABC) transporter
AL528_RS08925	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AL528_RS08935	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AL528_RS08940	COG0768	penicillin binding
AL528_RS08945	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AL528_RS08950	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AL528_RS08955	COG0705	Rhomboid family
AL528_RS08955	COG0457	Tetratricopeptide repeat
AL528_RS08960	COG4483	Protein conserved in bacteria
AL528_RS08965	COG1940	carbohydrate kinase activity
AL528_RS08970	COG0011	TIGRFAM Protein of
AL528_RS08975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AL528_RS08980	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AL528_RS08985	COG1459	type II secretion system
AL528_RS08990	COG4537	Required for transformation and DNA binding
AL528_RS09015	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AL528_RS09020	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AL528_RS09025	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL528_RS09030	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AL528_RS09035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AL528_RS09040	COG0095	Lipoate-protein ligase
AL528_RS09055	COG0006	proline dipeptidase activity
AL528_RS09060	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AL528_RS09065	COG0511	ligase activity, forming carbon-carbon bonds
AL528_RS09070	COG0439	Biotin carboxylase
AL528_RS09075	COG1302	Protein conserved in bacteria
AL528_RS09080	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL528_RS09085	COG1570	exodeoxyribonuclease VII activity
AL528_RS09090	COG1722	exodeoxyribonuclease VII activity
AL528_RS09100	COG1438	arginine binding
AL528_RS09105	COG0497	DNA recombination
AL528_RS09110	COG0280	phosphate acetyltransferase
AL528_RS09115	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AL528_RS09120	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AL528_RS09125	COG0022	dehydrogenase e1 component
AL528_RS09130	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL528_RS09140	COG4129	membrane
AL528_RS09145	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL528_RS09155	COG1609	Transcriptional regulator
AL528_RS09160	COG0366	Alpha amylase catalytic
AL528_RS09170	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AL528_RS09175	COG1234	tRNA 3'-trailer cleavage
AL528_RS09180	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AL528_RS09190	COG0667	Aldo Keto reductase
AL528_RS09195	COG0494	nUDIX hydrolase
AL528_RS09200	COG0735	belongs to the Fur family
AL528_RS09205	COG4974	Belongs to the 'phage' integrase family
AL528_RS09215	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AL528_RS09220	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AL528_RS09225	COG1187	pseudouridine synthase activity
AL528_RS09230	COG0745	RESPONSE REGULATOR receiver
AL528_RS09245	COG1141	Ferredoxin
AL528_RS09255	COG0514	ATP-dependent DNA helicase (RecQ)
AL528_RS09260	COG1388	LysM domain
AL528_RS09265	COG0492	ferredoxin-NADP+ reductase activity
AL528_RS09275	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AL528_RS09280	COG0539	negative regulation of cytoplasmic translation
AL528_RS09285	COG1160	GTP binding
AL528_RS09290	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AL528_RS09305	COG2226	methyltransferase
AL528_RS09310	COG0142	geranyltranstransferase activity
AL528_RS09315	COG0105	UTP biosynthetic process
AL528_RS09320	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AL528_RS09325	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AL528_RS09330	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AL528_RS09345	COG4347	Protein of unknown function (DUF1405)
AL528_RS09350	COG2738	Putative neutral zinc metallopeptidase
AL528_RS09355	COG1694	Mazg nucleotide pyrophosphohydrolase
AL528_RS09360	COG0438	transferase activity, transferring glycosyl groups
AL528_RS09365	COG0617	tRNA 3'-terminal CCA addition
AL528_RS09370	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AL528_RS09370	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AL528_RS09375	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AL528_RS09375	COG1199	ATP-dependent helicase activity
AL528_RS09380	COG0017	Asparaginyl-tRNA synthetase
AL528_RS09385	COG3935	DnaD domain protein
AL528_RS09390	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AL528_RS09400	COG4499	WXG100 protein secretion system (Wss), protein YukC
AL528_RS09400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AL528_RS09405	COG3331	DNA recombination
AL528_RS09415	COG4474	Belongs to the UPF0398 family
AL528_RS09420	COG3599	regulation of cell shape
AL528_RS09430	COG0116	Belongs to the methyltransferase superfamily
AL528_RS09435	COG2962	Rard protein
AL528_RS09450	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AL528_RS09455	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AL528_RS09460	COG0328	RNA-DNA hybrid ribonuclease activity
AL528_RS09465	COG3545	Serine hydrolase
AL528_RS09470	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AL528_RS09480	COG1413	lyase activity
AL528_RS09485	COG1413	lyase activity
AL528_RS09495	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AL528_RS09515	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AL528_RS09525	COG4479	Belongs to the UPF0346 family
AL528_RS09530	COG0793	Belongs to the peptidase S41A family
AL528_RS09540	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AL528_RS09545	COG0671	phosphoesterase, PA-phosphatase related
AL528_RS09550	COG0745	RESPONSE REGULATOR receiver
AL528_RS09555	COG5002	protein histidine kinase activity
AL528_RS09560	COG0567	Dehydrogenase, E1 component
AL528_RS09565	COG0508	dehydrogenase complex catalyzes the overall conversion of
AL528_RS09605	COG0673	inositol 2-dehydrogenase activity
AL528_RS09610	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AL528_RS09615	COG1121	(ABC) transporter
AL528_RS09640	COG0714	Associated with various cellular activities
AL528_RS09645	COG4548	von Willebrand factor, type A
AL528_RS09650	COG1114	Component of the transport system for branched-chain amino acids
AL528_RS09655	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL528_RS09660	COG3853	Toxic anion resistance protein (TelA)
AL528_RS09670	COG1254	Belongs to the acylphosphatase family
AL528_RS09680	COG1278	Cold shock
AL528_RS09695	COG1473	amidohydrolase
AL528_RS09700	COG2171	N-acyltransferase activity
AL528_RS09705	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AL528_RS09710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AL528_RS09715	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AL528_RS09720	COG0527	aspartate kinase activity
AL528_RS09730	COG0488	(ABC) transporter
AL528_RS09735	COG2996	Protein conserved in bacteria
AL528_RS09740	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AL528_RS09745	COG0573	inorganic phosphate transmembrane transporter activity
AL528_RS09750	COG0581	inorganic phosphate transmembrane transporter activity
AL528_RS09755	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AL528_RS09760	COG0704	Plays a role in the regulation of phosphate uptake
AL528_RS09765	COG1164	Oligoendopeptidase f
AL528_RS09775	COG4607	ABC-type enterochelin transport system periplasmic component
AL528_RS09785	COG2348	transferase activity, transferring amino-acyl groups
AL528_RS09790	COG2348	transferase activity, transferring amino-acyl groups
AL528_RS09800	COG0159	tryptophan synthase activity
AL528_RS09805	COG0133	tryptophan synthase activity
AL528_RS09810	COG0135	phosphoribosylanthranilate isomerase activity
AL528_RS09815	COG0134	indole-3-glycerol-phosphate synthase activity
AL528_RS09820	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AL528_RS09825	COG0512	Glutamine amidotransferase of anthranilate synthase
AL528_RS09830	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AL528_RS09840	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AL528_RS09845	COG1363	Peptidase, m42
AL528_RS09860	COG0287	Prephenate dehydrogenase
AL528_RS09865	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AL528_RS09870	COG1942	4-Oxalocrotonate Tautomerase
AL528_RS09885	COG1879	ABC-type sugar transport system periplasmic component
AL528_RS09890	COG1172	Belongs to the binding-protein-dependent transport system permease family
AL528_RS09895	COG1129	ABC transporter
AL528_RS09900	COG1869	D-ribose catabolic process
AL528_RS09905	COG1609	Transcriptional regulator
AL528_RS09910	COG0392	lysyltransferase activity
AL528_RS09910	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AL528_RS09915	COG0628	permease
AL528_RS09930	COG3711	transcriptional antiterminator
AL528_RS09935	COG1115	amino acid carrier protein
AL528_RS09940	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AL528_RS09950	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AL528_RS09955	COG4841	protein insertion into membrane
AL528_RS09960	COG0824	Thioesterase
AL528_RS09965	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AL528_RS09970	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AL528_RS09975	COG1970	mechanosensitive ion channel activity
AL528_RS09980	COG0419	ATPase involved in DNA repair
AL528_RS09985	COG0420	3'-5' exonuclease activity
AL528_RS09990	COG4846	Membrane protein involved in cytochrome C biogenesis
AL528_RS10005	COG3763	UPF0154 protein
AL528_RS10025	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AL528_RS10035	COG0516	GMP reductase activity
AL528_RS10040	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AL528_RS10045	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AL528_RS10050	COG0753	catalase activity
AL528_RS10055	COG0833	amino acid
AL528_RS10065	COG0561	phosphatase activity
AL528_RS10070	COG0083	homoserine kinase activity
AL528_RS10075	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AL528_RS10080	COG0460	homoserine dehydrogenase
AL528_RS10085	COG0527	aspartate kinase activity
AL528_RS10115	COG2197	response regulator
AL528_RS10120	COG2203	Gaf domain
AL528_RS10120	COG4585	Histidine kinase
AL528_RS10125	COG0842	Transport permease protein
AL528_RS10130	COG1131	(ABC) transporter
AL528_RS10140	COG0174	glutamine synthetase
AL528_RS10145	COG0789	Transcriptional regulator
AL528_RS10150	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AL528_RS10155	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AL528_RS10160	COG0386	Belongs to the glutathione peroxidase family
AL528_RS10165	COG1923	regulation of RNA biosynthetic process
AL528_RS10170	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AL528_RS10180	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AL528_RS10185	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AL528_RS10190	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AL528_RS10205	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AL528_RS10210	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AL528_RS10220	COG4550	Control of competence regulator ComK, YlbF/YmcA
AL528_RS10225	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AL528_RS10250	COG1013	pyruvate-flavodoxin oxidoreductase activity
AL528_RS10255	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AL528_RS10255	COG0674	pyruvate-flavodoxin oxidoreductase activity
AL528_RS10260	COG1692	metallophosphoesterase
AL528_RS10270	COG1418	mRNA catabolic process
AL528_RS10275	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AL528_RS10280	COG1546	Belongs to the CinA family
AL528_RS10280	COG1058	Belongs to the CinA family
AL528_RS10300	COG0300	oxidoreductase activity
AL528_RS10305	COG0612	Peptidase, M16
AL528_RS10310	COG0612	Peptidase, M16
AL528_RS10315	COG2188	Transcriptional regulator
AL528_RS10320	COG1674	ftsk spoiiie
AL528_RS10325	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AL528_RS10330	COG1185	polyribonucleotide nucleotidyltransferase activity
AL528_RS10335	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AL528_RS10340	COG0196	riboflavin kinase activity
AL528_RS10345	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AL528_RS10350	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AL528_RS10365	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AL528_RS10370	COG1358	cellular component organization or biogenesis
AL528_RS10375	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AL528_RS10380	COG0195	Participates in both transcription termination and antitermination
AL528_RS10385	COG0779	Required for maturation of 30S ribosomal subunits
AL528_RS10390	COG2176	DNA-directed DNA polymerase activity
AL528_RS10395	COG0442	prolyl-tRNA aminoacylation
AL528_RS10405	COG4589	Belongs to the CDS family
AL528_RS10410	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AL528_RS10415	COG0233	cytoplasmic translational termination
AL528_RS10420	COG0528	UMP kinase activity
AL528_RS10425	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AL528_RS10430	COG0052	Belongs to the universal ribosomal protein uS2 family
AL528_RS10435	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AL528_RS10440	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AL528_RS10445	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AL528_RS10450	COG4974	Belongs to the 'phage' integrase family
AL528_RS10455	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AL528_RS10460	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AL528_RS10465	COG0758	DNA mediated transformation
AL528_RS10475	COG0045	succinate-CoA ligase (ADP-forming) activity
AL528_RS10480	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AL528_RS10490	COG4485	Bacterial membrane protein, YfhO
AL528_RS10500	COG0335	large ribosomal subunit rRNA binding
AL528_RS10505	COG0336	Belongs to the RNA methyltransferase TrmD family
AL528_RS10510	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AL528_RS10515	COG0228	four-way junction DNA binding
AL528_RS10520	COG1028	Short-chain dehydrogenase reductase Sdr
AL528_RS10525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AL528_RS10530	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AL528_RS10535	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AL528_RS10540	COG0552	protein localization to endoplasmic reticulum
AL528_RS10545	COG1196	nuclear chromosome segregation
AL528_RS10550	COG0571	ribonuclease III activity
AL528_RS10555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL528_RS10570	COG0416	fatty acid biosynthetic process
AL528_RS10575	COG1349	DNA-binding transcription factor activity
AL528_RS10585	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AL528_RS10590	COG1760	l-serine dehydratase
AL528_RS10595	COG1760	l-serine dehydratase
AL528_RS10600	COG1461	Dihydroxyacetone kinase
AL528_RS10605	COG1302	Protein conserved in bacteria
AL528_RS10610	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AL528_RS10615	COG1564	THIamine pyrophosphokinase
AL528_RS10620	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AL528_RS10625	COG1162	GTPase activity
AL528_RS10635	COG0631	protein serine/threonine phosphatase activity
AL528_RS10640	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AL528_RS10645	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AL528_RS10645	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AL528_RS10650	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AL528_RS10655	COG0242	peptide deformylase activity
AL528_RS10665	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AL528_RS10670	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AL528_RS10675	COG1758	RNA polymerase activity
AL528_RS10680	COG0194	GDP metabolic process
AL528_RS10685	COG1293	RNA-binding protein homologous to eukaryotic snRNP
AL528_RS10695	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AL528_RS10705	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AL528_RS10710	COG0284	orotidine-5'-phosphate decarboxylase activity
AL528_RS10715	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AL528_RS10720	COG0505	Belongs to the CarA family
AL528_RS10730	COG0540	Belongs to the ATCase OTCase family
AL528_RS10740	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AL528_RS10745	COG0564	pseudouridine synthase activity
AL528_RS10750	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AL528_RS10760	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AL528_RS10765	COG3599	regulation of cell shape
AL528_RS10775	COG0762	integral membrane protein
AL528_RS10780	COG1799	cell septum assembly
AL528_RS10785	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AL528_RS10790	COG1496	oxidoreductase activity
AL528_RS10795	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AL528_RS10800	COG0849	cell division
AL528_RS10805	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AL528_RS10810	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AL528_RS10815	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL528_RS10820	COG0768	penicillin binding
AL528_RS10825	COG4839	cell division protein FtsL
AL528_RS10830	COG0275	rRNA processing
AL528_RS10835	COG2001	Belongs to the MraZ family
AL528_RS10840	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
AL528_RS10845	COG0454	-acetyltransferase
AL528_RS10850	COG1011	Hydrolase
AL528_RS10890	COG2801	Transposase and inactivated derivatives
AL528_RS10915	COG2261	transglycosylase associated protein
AL528_RS11015	COG0052	Belongs to the universal ribosomal protein uS2 family
AL528_RS11045	COG5484	DNA packaging
AL528_RS11045	COG3728	DNA packaging
AL528_RS11095	COG3723	Recombinational DNA repair protein, rece pathway
AL528_RS11100	COG5377	YqaJ viral recombinase family
AL528_RS11150	COG0582	viral genome integration into host DNA
AL528_RS11170	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AL528_RS11175	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AL528_RS11180	COG1053	succinate dehydrogenase
AL528_RS11185	COG2009	succinate dehydrogenase
AL528_RS11190	COG0322	excinuclease ABC activity
AL528_RS11195	COG3118	belongs to the thioredoxin family
AL528_RS11200	COG1193	negative regulation of DNA recombination
AL528_RS11205	COG1796	DNA polymerase
AL528_RS11205	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AL528_RS11215	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AL528_RS11220	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AL528_RS11225	COG0072	phenylalanine-tRNA ligase activity
AL528_RS11230	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AL528_RS11235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AL528_RS11245	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AL528_RS11255	COG1323	Belongs to the UPF0348 family
AL528_RS11260	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AL528_RS11265	COG0742	ribosomal rna small subunit methyltransferase
AL528_RS11280	COG0584	glycerophosphoryl diester phosphodiesterase
AL528_RS11285	COG3679	Belongs to the UPF0342 family
AL528_RS11305	COG0109	protoheme IX farnesyltransferase activity
AL528_RS11310	COG1612	heme a metabolic process
AL528_RS11320	COG0772	Belongs to the SEDS family
AL528_RS11325	COG4838	Belongs to the UPF0358 family
AL528_RS11330	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AL528_RS11335	COG1217	gtp-binding protein TYPA
AL528_RS11345	COG0483	inositol monophosphate 1-phosphatase activity
AL528_RS11350	COG4493	Belongs to the UPF0637 family
AL528_RS11360	COG1914	H( )-stimulated, divalent metal cation uptake system
AL528_RS11375	COG1177	transmembrane transport
AL528_RS11380	COG1176	ABC-type spermidine putrescine transport system, permease component I
AL528_RS11385	COG3842	ATPase activity
AL528_RS11395	COG4476	Belongs to the UPF0223 family
AL528_RS11435	COG5503	Protein of unknown function (DUF1447)
AL528_RS11440	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AL528_RS11450	COG0569	domain protein
AL528_RS11455	COG1294	oxidase, subunit
AL528_RS11460	COG1271	oxidase subunit
AL528_RS11475	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AL528_RS11485	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AL528_RS11500	COG4172	Belongs to the ABC transporter superfamily
AL528_RS11505	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AL528_RS11510	COG0151	Belongs to the GarS family
AL528_RS11515	COG0138	bifunctional purine biosynthesis protein purh
AL528_RS11525	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AL528_RS11535	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AL528_RS11540	COG0047	phosphoribosylformylglycinamidine synthase activity
AL528_RS11545	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AL528_RS11550	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AL528_RS11555	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AL528_RS11560	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AL528_RS11565	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AL528_RS11570	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AL528_RS11570	COG1017	nitric oxide dioxygenase activity
AL528_RS11580	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AL528_RS11585	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AL528_RS11590	COG1845	cytochrome c oxidase, subunit III
AL528_RS11595	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AL528_RS11605	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AL528_RS11610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AL528_RS11615	COG1316	TRANSCRIPTIONal
AL528_RS11640	COG3594	Acyltransferase
AL528_RS11645	COG0436	Aminotransferase
AL528_RS11655	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AL528_RS11665	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AL528_RS11670	COG1169	isochorismate synthase
AL528_RS11675	COG1575	Belongs to the MenA family. Type 1 subfamily
AL528_RS11685	COG2314	TM2 domain
AL528_RS11690	COG1764	response to oxidative stress
AL528_RS11705	COG4903	ComK protein
AL528_RS11720	COG4873	Protein conserved in bacteria
AL528_RS11730	COG0737	Belongs to the 5'-nucleotidase family
AL528_RS11735	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AL528_RS11740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AL528_RS11745	COG0861	Integral membrane protein TerC family
AL528_RS11750	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AL528_RS11760	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AL528_RS11765	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AL528_RS11770	COG2814	Major facilitator Superfamily
AL528_RS11775	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AL528_RS11780	COG2382	esterase
AL528_RS11785	COG1115	amino acid carrier protein
AL528_RS11790	COG0628	permease
AL528_RS11800	COG0475	glutathione-regulated potassium exporter activity
AL528_RS11800	COG0569	domain protein
AL528_RS11805	COG2239	Acts as a magnesium transporter
AL528_RS11810	COG0564	pseudouridine synthase activity
AL528_RS11815	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AL528_RS11820	COG2357	RelA SpoT domain protein
AL528_RS11830	COG4116	CYTH
AL528_RS11835	COG2346	COG2346, Truncated hemoglobins
AL528_RS11840	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AL528_RS11845	COG2910	NAD(P)H-binding
AL528_RS11850	COG1164	Oligoendopeptidase f
AL528_RS11860	COG4862	establishment of competence for transformation
AL528_RS11865	COG1393	Belongs to the ArsC family
AL528_RS11870	COG0180	Tryptophanyl-tRNA synthetase
AL528_RS11875	COG4166	transmembrane transport
AL528_RS11880	COG4608	Belongs to the ABC transporter superfamily
AL528_RS11885	COG0444	Belongs to the ABC transporter superfamily
AL528_RS11890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AL528_RS11895	COG0601	transmembrane transport
AL528_RS11915	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AL528_RS11925	COG0542	response to heat
AL528_RS11940	COG0561	phosphatase activity
AL528_RS11945	COG0446	pyridine nucleotide-disulphide oxidoreductase
AL528_RS11955	COG0179	Fumarylacetoacetate (FAA) hydrolase
AL528_RS11960	COG2311	Membrane
AL528_RS11965	COG1074	ATP-dependent DNA helicase activity
AL528_RS11970	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AL528_RS11985	COG0398	Pfam SNARE associated Golgi protein
AL528_RS11990	COG0166	Belongs to the GPI family
AL528_RS11995	COG0137	argininosuccinate synthase activity
AL528_RS12000	COG0165	Argininosuccinate lyase
AL528_RS12015	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AL528_RS12020	COG1902	pentaerythritol trinitrate reductase activity
AL528_RS12025	COG1098	S1 RNA binding domain
AL528_RS12030	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AL528_RS12040	COG2111	Na H antiporter
AL528_RS12040	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AL528_RS12045	COG2111	Na H antiporter
AL528_RS12050	COG1006	Multisubunit Na H antiporter MnhC subunit
AL528_RS12055	COG0651	ATP synthesis coupled electron transport
AL528_RS12060	COG1863	multisubunit Na H antiporter MnhE subunit
AL528_RS12065	COG2212	antiporter activity
AL528_RS12070	COG1320	monovalent cation:proton antiporter activity
AL528_RS12080	COG2050	protein possibly involved in aromatic compounds catabolism
AL528_RS12085	COG2056	Na+-H+ antiporter family
AL528_RS12090	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AL528_RS12095	COG1252	NADH dehydrogenase
AL528_RS12100	COG0316	Belongs to the HesB IscA family
AL528_RS12105	COG4844	belongs to the
AL528_RS12110	COG1252	NADH dehydrogenase
AL528_RS12115	COG4837	Protein of unknown function (DUF1462)
AL528_RS12120	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AL528_RS12125	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AL528_RS12130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AL528_RS12135	COG1696	Membrane protein involved in D-alanine export
AL528_RS12140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AL528_RS12155	COG0647	UMP catabolic process
AL528_RS12160	COG2445	Protein of unknown function DUF86
AL528_RS12170	COG4470	Protein conserved in bacteria
AL528_RS12175	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AL528_RS12180	COG0737	Belongs to the 5'-nucleotidase family
AL528_RS12185	COG0730	response to heat
AL528_RS12190	COG1801	Protein of unknown function DUF72
AL528_RS12195	COG2070	2-Nitropropane dioxygenase
AL528_RS12200	COG1253	flavin adenine dinucleotide binding
AL528_RS12205	COG0719	Fe-S assembly protein
AL528_RS12210	COG0822	iron-sulfur transferase activity
AL528_RS12215	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AL528_RS12220	COG0719	Fe-S assembly protein
AL528_RS12225	COG0396	ATPase activity
AL528_RS12235	COG1253	flavin adenine dinucleotide binding
AL528_RS12245	COG1464	Belongs to the NlpA lipoprotein family
AL528_RS12250	COG2011	ABC-type metal ion transport system permease component
AL528_RS12255	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AL528_RS12260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL528_RS12265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AL528_RS12270	COG0509	glycine decarboxylation via glycine cleavage system
AL528_RS12275	COG1393	Belongs to the ArsC family
AL528_RS12280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AL528_RS12285	COG0778	Nitroreductase
AL528_RS12290	COG0710	3-dehydroquinate dehydratase activity
AL528_RS12295	COG1764	response to oxidative stress
AL528_RS12310	COG2851	Citrate transporter
AL528_RS12325	COG2314	TM2 domain
AL528_RS12415	COG0346	lactoylglutathione lyase activity
AL528_RS12470	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AL528_RS12475	COG0557	exoribonuclease II activity
AL528_RS12480	COG1647	Serine aminopeptidase, S33
AL528_RS12485	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AL528_RS12500	COG0148	phosphopyruvate hydratase activity
AL528_RS12505	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AL528_RS12510	COG0149	triose-phosphate isomerase activity
AL528_RS12515	COG0126	phosphoglycerate kinase activity
AL528_RS12545	COG1090	epimerase
AL528_RS12555	COG0740	serine-type endopeptidase activity
AL528_RS12570	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AL528_RS12575	COG1481	regulation of sporulation
AL528_RS12580	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AL528_RS12585	COG1660	Displays ATPase and GTPase activities
AL528_RS12590	COG0492	ferredoxin-NADP+ reductase activity
AL528_RS12600	COG0110	maltose O-acetyltransferase activity
AL528_RS12605	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AL528_RS12610	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AL528_RS12620	COG0556	nucleotide-excision repair
AL528_RS12635	COG3942	CHAP domain
AL528_RS12635	COG1388	LysM domain
AL528_RS12640	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AL528_RS12645	COG0653	protein targeting
AL528_RS12650	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AL528_RS12655	COG1040	competence protein
AL528_RS12660	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AL528_RS12670	COG1739	Uncharacterized protein family UPF0029
AL528_RS12675	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AL528_RS12680	COG2199	diguanylate cyclase activity
AL528_RS12695	COG2195	Cleaves the N-terminal amino acid of tripeptides
AL528_RS12970	COG0514	ATP-dependent DNA helicase (RecQ)