locus-tag	class	description
I7831_RS00010	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I7831_RS00015	COG1461	Dihydroxyacetone kinase
I7831_RS00020	COG2376	Dihydroxyacetone kinase
I7831_RS00025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I7831_RS00030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I7831_RS00035	COG1120	ATPase activity
I7831_RS00040	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I7831_RS00045	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I7831_RS00050	COG1132	(ABC) transporter
I7831_RS00060	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I7831_RS00065	COG1442	glycosyl transferase family 8
I7831_RS00065	COG1216	Glycosyl transferase, family 2
I7831_RS00070	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I7831_RS00075	COG1682	transport, permease protein
I7831_RS00080	COG1134	teichoic acid transport
I7831_RS00085	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I7831_RS00100	COG1121	(ABC) transporter
I7831_RS00105	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I7831_RS00110	COG0803	Belongs to the bacterial solute-binding protein 9 family
I7831_RS00120	COG1320	monovalent cation:proton antiporter activity
I7831_RS00125	COG2212	antiporter activity
I7831_RS00130	COG1863	multisubunit Na H antiporter MnhE subunit
I7831_RS00135	COG0651	ATP synthesis coupled electron transport
I7831_RS00140	COG1006	Multisubunit Na H antiporter MnhC subunit
I7831_RS00145	COG2111	Na H antiporter
I7831_RS00150	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I7831_RS00150	COG2111	Na H antiporter
I7831_RS00155	COG4974	Belongs to the 'phage' integrase family
I7831_RS00190	COG0596	Alpha beta hydrolase
I7831_RS00210	COG0546	phosphoglycolate phosphatase activity
I7831_RS00215	COG4139	cobalamin transport
I7831_RS00220	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I7831_RS00225	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I7831_RS00230	COG0018	arginyl-trna synthetase
I7831_RS00245	COG1078	dGTPase activity
I7831_RS00250	COG0456	acetyltransferase
I7831_RS00260	COG0667	Aldo Keto reductase
I7831_RS00265	COG4844	belongs to the
I7831_RS00270	COG1082	Xylose isomerase domain protein TIM barrel
I7831_RS00275	COG0673	inositol 2-dehydrogenase activity
I7831_RS00285	COG0673	inositol 2-dehydrogenase activity
I7831_RS00290	COG1737	Transcriptional regulator
I7831_RS00295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7831_RS00295	COG1263	PTS System
I7831_RS00315	COG0095	Lipoate-protein ligase
I7831_RS00320	COG0280	phosphate acetyltransferase
I7831_RS00325	COG3253	May function as heme-dependent peroxidase
I7831_RS00345	COG2363	Small membrane protein
I7831_RS00355	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I7831_RS00360	COG0351	phosphomethylpyrimidine kinase
I7831_RS00380	COG0534	Mate efflux family protein
I7831_RS00410	COG0318	PFAM AMP-dependent synthetase and ligase
I7831_RS00420	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I7831_RS00425	COG0363	glucosamine-6-phosphate deaminase activity
I7831_RS00435	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I7831_RS00440	COG1469	GTP cyclohydrolase I activity
I7831_RS00450	COG0431	NADPH-dependent FMN reductase
I7831_RS00455	COG0561	phosphatase activity
I7831_RS00465	COG1428	Deoxynucleoside kinase
I7831_RS00470	COG1428	Deoxynucleoside kinase
I7831_RS00480	COG0546	phosphoglycolate phosphatase activity
I7831_RS00500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I7831_RS00515	COG2814	Major facilitator Superfamily
I7831_RS00520	COG2824	Alkylphosphonate utilization operon protein PhnA
I7831_RS00530	COG1113	amino acid transport
I7831_RS00535	COG2040	homocysteine
I7831_RS00540	COG0833	amino acid
I7831_RS00550	COG0010	Belongs to the arginase family
I7831_RS00555	COG1914	H( )-stimulated, divalent metal cation uptake system
I7831_RS00565	COG1069	ribulokinase activity
I7831_RS00570	COG1063	alcohol dehydrogenase
I7831_RS00575	COG2814	Major facilitator Superfamily
I7831_RS00580	COG1349	DNA-binding transcription factor activity
I7831_RS00585	COG2801	Transposase and inactivated derivatives
I7831_RS00600	COG0583	DNA-binding transcription factor activity
I7831_RS00625	COG0667	Aldo Keto reductase
I7831_RS00635	COG3477	response to acidic pH
I7831_RS00650	COG1682	transport, permease protein
I7831_RS00665	COG1028	Short-chain dehydrogenase reductase Sdr
I7831_RS00670	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I7831_RS00675	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I7831_RS00705	COG1473	amidohydrolase
I7831_RS00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I7831_RS00715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I7831_RS00720	COG0049	tRNA binding
I7831_RS00725	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I7831_RS00735	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I7831_RS00740	COG0085	RNA polymerase activity
I7831_RS00745	COG2813	Specifically methylates the guanine in position
I7831_RS00750	COG0222	ribosome binding
I7831_RS00755	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I7831_RS00760	COG0081	regulation of translation
I7831_RS00765	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I7831_RS00775	COG0250	Participates in transcription elongation, termination and antitermination
I7831_RS00785	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I7831_RS00800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I7831_RS00805	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I7831_RS00810	COG0215	cysteine-tRNA ligase activity
I7831_RS00815	COG1045	serine acetyltransferase
I7831_RS00820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I7831_RS00825	COG4956	integral membrane protein (PIN domain superfamily)
I7831_RS00830	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I7831_RS00840	COG0542	response to heat
I7831_RS00845	COG3869	Catalyzes the specific phosphorylation of arginine residues in
I7831_RS00850	COG3880	PFAM UvrB UvrC protein
I7831_RS00855	COG4463	regulation of RNA biosynthetic process
I7831_RS00860	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I7831_RS00865	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I7831_RS00870	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I7831_RS00875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I7831_RS00960	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I7831_RS00965	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I7831_RS00985	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I7831_RS00990	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I7831_RS01005	COG1098	S1 RNA binding domain
I7831_RS01015	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I7831_RS01020	COG3956	TIGRFAM MazG family protein
I7831_RS01025	COG2244	polysaccharide biosynthetic process
I7831_RS01030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I7831_RS01035	COG0193	aminoacyl-tRNA hydrolase activity
I7831_RS01040	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I7831_RS01045	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I7831_RS01050	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I7831_RS01055	COG2088	sporulation resulting in formation of a cellular spore
I7831_RS01060	COG0251	oxidation-reduction process
I7831_RS01065	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I7831_RS01070	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I7831_RS01075	COG4466	Protein conserved in bacteria
I7831_RS01080	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I7831_RS01085	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I7831_RS01090	COG0084	hydrolase, TatD family'
I7831_RS01095	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I7831_RS01095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I7831_RS01100	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I7831_RS01105	COG2827	Endonuclease containing a URI domain
I7831_RS01110	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I7831_RS01115	COG4467	Involved in initiation control of chromosome replication
I7831_RS01120	COG1774	PSP1 C-terminal conserved region
I7831_RS01125	COG0470	DNA polymerase III
I7831_RS01130	COG3870	Protein conserved in bacteria
I7831_RS01135	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I7831_RS01140	COG1982	Orn Lys Arg decarboxylase major
I7831_RS01160	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I7831_RS01165	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I7831_RS01170	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I7831_RS01185	COG2188	Transcriptional regulator
I7831_RS01190	COG0366	Alpha amylase catalytic
I7831_RS01195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7831_RS01195	COG1263	PTS System
I7831_RS01205	COG0493	'glutamate synthase
I7831_RS01210	COG0070	glutamate synthase
I7831_RS01210	COG0067	glutamate synthase
I7831_RS01210	COG0069	glutamate synthase activity
I7831_RS01215	COG0583	DNA-binding transcription factor activity
I7831_RS01230	COG0004	ammonium transporteR
I7831_RS01235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I7831_RS01245	COG1388	LysM domain
I7831_RS01245	COG3942	CHAP domain
I7831_RS01255	COG0129	dihydroxy-acid dehydratase activity
I7831_RS01270	COG0733	neurotransmitter:sodium symporter activity
I7831_RS01275	COG1114	Component of the transport system for branched-chain amino acids
I7831_RS01280	COG5646	InterPro IPR014922
I7831_RS01285	COG1647	Serine aminopeptidase, S33
I7831_RS01295	COG2807	transmembrane transport
I7831_RS01300	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I7831_RS01300	COG0456	acetyltransferase
I7831_RS01305	COG2814	Major facilitator Superfamily
I7831_RS01310	COG0583	DNA-binding transcription factor activity
I7831_RS01315	COG2814	Major facilitator Superfamily
I7831_RS01340	COG1301	dicarboxylic acid transport
I7831_RS01365	COG0519	Catalyzes the synthesis of GMP from XMP
I7831_RS01365	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I7831_RS01370	COG0517	IMP dehydrogenase activity
I7831_RS01370	COG0516	GMP reductase activity
I7831_RS01375	COG2233	PERMEase
I7831_RS01380	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I7831_RS01400	COG1823	symporter activity
I7831_RS01410	COG0778	Nitroreductase
I7831_RS01415	COG3620	sequence-specific DNA binding
I7831_RS01420	COG0450	alkyl hydroperoxide reductase
I7831_RS01425	COG3634	alkyl hydroperoxide reductase activity
I7831_RS01460	COG1280	lysine exporter protein (LysE YggA)
I7831_RS01465	COG2076	Multidrug Resistance protein
I7831_RS01470	COG2076	Multidrug Resistance protein
I7831_RS01490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I7831_RS01510	COG4195	phage-related replication protein
I7831_RS01515	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I7831_RS01525	COG1522	sequence-specific DNA binding
I7831_RS01550	COG2808	Putative FMN-binding domain
I7831_RS01610	COG0456	acetyltransferase
I7831_RS01650	COG0583	DNA-binding transcription factor activity
I7831_RS01665	COG4221	oxidoreductase activity
I7831_RS01670	COG1733	regulation of RNA biosynthetic process
I7831_RS01675	COG1012	belongs to the aldehyde dehydrogenase family
I7831_RS01690	COG0753	catalase activity
I7831_RS01730	COG3682	Transcriptional regulator
I7831_RS01750	COG1063	alcohol dehydrogenase
I7831_RS01755	COG1846	Transcriptional regulator
I7831_RS01760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I7831_RS01780	COG1876	peptidase activity
I7831_RS01790	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I7831_RS01800	COG1595	DNA-templated transcription, initiation
I7831_RS01805	COG4221	oxidoreductase activity
I7831_RS01825	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I7831_RS01850	COG1607	acyl-coa hydrolase
I7831_RS01855	COG0583	DNA-binding transcription factor activity
I7831_RS01865	COG0693	protein deglycase activity
I7831_RS01890	COG1028	Short-chain dehydrogenase reductase Sdr
I7831_RS01890	COG3321	synthase
I7831_RS01890	COG0604	alcohol dehydrogenase
I7831_RS01935	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I7831_RS01945	COG0360	Binds together with S18 to 16S ribosomal RNA
I7831_RS01955	COG0012	GTP binding
I7831_RS01960	COG4481	Protein conserved in bacteria
I7831_RS01965	COG0668	transmembrane transport
I7831_RS01970	COG5609	conserved protein (DUF2294)
I7831_RS01975	COG3002	Belongs to the UPF0753 family
I7831_RS01980	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I7831_RS02010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I7831_RS02015	COG2814	Major facilitator Superfamily
I7831_RS02020	COG1473	amidohydrolase
I7831_RS02025	COG2814	Major facilitator Superfamily
I7831_RS02030	COG1733	regulation of RNA biosynthetic process
I7831_RS02035	COG3759	membrane
I7831_RS02040	COG2814	Major facilitator Superfamily
I7831_RS02065	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I7831_RS02075	COG0529	Catalyzes the synthesis of activated sulfate
I7831_RS02080	COG2046	Belongs to the sulfate adenylyltransferase family
I7831_RS02085	COG0730	response to heat
I7831_RS02105	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I7831_RS02110	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I7831_RS02115	COG0175	sulfate reduction
I7831_RS02130	COG1475	DNA binding
I7831_RS02135	COG0626	cystathionine gamma-synthase activity
I7831_RS02140	COG0626	cystathionine gamma-synthase activity
I7831_RS02145	COG0646	methionine synthase
I7831_RS02145	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I7831_RS02150	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I7831_RS02160	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I7831_RS02185	COG0183	Belongs to the thiolase family
I7831_RS02195	COG1960	acyl-CoA dehydrogenase activity
I7831_RS02200	COG0318	PFAM AMP-dependent synthetase and ligase
I7831_RS02210	COG0531	amino acid
I7831_RS02215	COG0656	L-ascorbic acid biosynthetic process
I7831_RS02260	COG1966	Carbon starvation protein
I7831_RS02265	COG1475	DNA binding
I7831_RS02270	COG0357	Ribosomal RNA small subunit methyltransferase G
I7831_RS02275	COG0445	tRNA wobble uridine modification
I7831_RS02280	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I7831_RS02285	COG0594	ribonuclease P activity
I7831_RS02295	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I7831_RS02300	COG0592	DNA-directed DNA polymerase activity
I7831_RS02305	COG2501	S4 domain
I7831_RS02310	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I7831_RS02315	COG0187	DNA topoisomerase II activity
I7831_RS02325	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I7831_RS02330	COG2986	histidine ammonia-lyase
I7831_RS02335	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I7831_RS02340	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I7831_RS02350	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I7831_RS02360	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I7831_RS02365	COG0359	binds to the 23S rRNA
I7831_RS02370	COG0305	Participates in initiation and elongation during chromosome replication
I7831_RS02375	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I7831_RS02380	COG1819	glycosyl
I7831_RS02400	COG0477	Major facilitator Superfamily
I7831_RS02405	COG0745	RESPONSE REGULATOR receiver
I7831_RS02410	COG5002	protein histidine kinase activity
I7831_RS02415	COG4863	YycH protein
I7831_RS02425	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I7831_RS02430	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I7831_RS02460	COG2030	dehydratase
I7831_RS02495	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I7831_RS02600	COG1086	Polysaccharide biosynthesis protein
I7831_RS02610	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I7831_RS02630	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I7831_RS02635	COG0297	glycogen (starch) synthase activity
I7831_RS02640	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I7831_RS02715	COG0640	Transcriptional regulator
I7831_RS02720	COG2217	Heavy metal translocating P-type atpase
I7831_RS02735	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I7831_RS02745	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I7831_RS02765	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I7831_RS02795	COG0730	response to heat
I7831_RS02800	COG1937	Protein conserved in bacteria
I7831_RS02805	COG2210	Belongs to the sulfur carrier protein TusA family
I7831_RS02810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I7831_RS02820	COG1695	Transcriptional regulator
I7831_RS02830	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I7831_RS02840	COG2217	Heavy metal translocating P-type atpase
I7831_RS02845	COG1388	LysM domain
I7831_RS02850	COG1401	restriction endodeoxyribonuclease activity
I7831_RS02855	COG4268	DNA restriction-modification system
I7831_RS02875	COG3942	CHAP domain
I7831_RS02875	COG1705	Flagellar rod assembly protein muramidase FlgJ
I7831_RS02920	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I7831_RS02930	COG0789	Transcriptional regulator
I7831_RS02940	COG0702	epimerase
I7831_RS02945	COG2130	NADP-dependent
I7831_RS02960	COG0702	epimerase
I7831_RS02965	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
I7831_RS03000	COG0415	Belongs to the DNA photolyase family
I7831_RS03020	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I7831_RS03025	COG2022	thiamine diphosphate biosynthetic process
I7831_RS03035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I7831_RS03045	COG1070	Carbohydrate kinase
I7831_RS03055	COG2814	Major facilitator Superfamily
I7831_RS03110	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I7831_RS03120	COG0579	oxidoreductase
I7831_RS03125	COG0028	Belongs to the TPP enzyme family
I7831_RS03130	COG3527	Alpha-acetolactate decarboxylase
I7831_RS03135	COG1620	l-lactate permease
I7831_RS03140	COG0583	DNA-binding transcription factor activity
I7831_RS03160	COG1136	(ABC) transporter
I7831_RS03170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I7831_RS03210	COG0596	Alpha beta hydrolase
I7831_RS03250	COG1733	regulation of RNA biosynthetic process
I7831_RS03255	COG2207	Transcriptional regulator
I7831_RS03260	COG2211	Major facilitator Superfamily
I7831_RS03265	COG3250	beta-galactosidase activity
I7831_RS03280	COG3949	Membrane
I7831_RS03290	COG1131	(ABC) transporter
I7831_RS03300	COG1476	TRANSCRIPTIONal
I7831_RS03320	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
I7831_RS03335	COG0463	Glycosyl transferase, family 2
I7831_RS03375	COG1028	Short-chain dehydrogenase reductase Sdr
I7831_RS03385	COG1388	LysM domain
I7831_RS03390	COG1388	LysM domain
I7831_RS03410	COG2190	(PTS) system
I7831_RS03410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7831_RS03410	COG1263	PTS System
I7831_RS03430	COG1054	Belongs to the UPF0176 family
I7831_RS03460	COG1131	(ABC) transporter
I7831_RS03470	COG5295	Hep Hag repeat protein
I7831_RS03470	COG4932	domain protein
I7831_RS03470	COG5295	Hep Hag repeat protein
I7831_RS03470	COG4932	domain protein
I7831_RS03480	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I7831_RS03485	COG1511	domain protein
I7831_RS03485	COG1511	domain protein
I7831_RS03510	COG1328	CTP reductase activity
I7831_RS03520	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I7831_RS03525	COG0346	lactoylglutathione lyase activity
I7831_RS03555	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I7831_RS03560	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I7831_RS03565	COG0579	oxidoreductase
I7831_RS03615	COG0477	Major facilitator Superfamily
I7831_RS03625	COG2814	Major facilitator Superfamily
I7831_RS03630	COG0583	DNA-binding transcription factor activity
I7831_RS03645	COG0584	glycerophosphoryl diester phosphodiesterase
I7831_RS03650	COG1846	Transcriptional regulator
I7831_RS03655	COG3961	Belongs to the TPP enzyme family
I7831_RS03675	COG0673	inositol 2-dehydrogenase activity
I7831_RS03680	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
I7831_RS03685	COG1691	(AIR) carboxylase
I7831_RS03690	COG1606	tRNA processing
I7831_RS03695	COG3875	lactate racemase activity
I7831_RS03705	COG3835	regulator
I7831_RS03710	COG0574	Belongs to the PEP-utilizing enzyme family
I7831_RS03710	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I7831_RS03715	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I7831_RS03725	COG1396	sequence-specific DNA binding
I7831_RS03730	COG2807	transmembrane transport
I7831_RS03740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I7831_RS03745	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I7831_RS03750	COG1012	belongs to the aldehyde dehydrogenase family
I7831_RS03755	COG0531	amino acid
I7831_RS03770	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I7831_RS03775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I7831_RS03780	COG1510	regulation of RNA biosynthetic process
I7831_RS03785	COG1012	belongs to the aldehyde dehydrogenase family
I7831_RS03790	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I7831_RS03800	COG0463	Glycosyl transferase, family 2
I7831_RS03800	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I7831_RS03810	COG2271	Major facilitator Superfamily
I7831_RS03820	COG2843	Capsule synthesis protein
I7831_RS03825	COG1957	nucleoside hydrolase
I7831_RS03830	COG0477	Major facilitator Superfamily
I7831_RS03850	COG1131	(ABC) transporter
I7831_RS03855	COG2610	gluconate transmembrane transporter activity
I7831_RS03860	COG0531	amino acid
I7831_RS03865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I7831_RS03870	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I7831_RS03875	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I7831_RS03880	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I7831_RS03895	COG0431	NADPH-dependent FMN reductase
I7831_RS03900	COG3226	Transcriptional regulator
I7831_RS03920	COG2814	Major facilitator Superfamily
I7831_RS03935	COG0363	glucosamine-6-phosphate deaminase activity
I7831_RS03950	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I7831_RS03960	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I7831_RS03965	COG1447	Phosphotransferase system cellobiose-specific component IIA
I7831_RS03970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I7831_RS03975	COG0765	amino acid transport
I7831_RS03980	COG1126	abc transporter atp-binding protein
I7831_RS03985	COG3711	transcriptional antiterminator
I7831_RS03990	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I7831_RS04000	COG3037	sugar-specific permease SgaT UlaA
I7831_RS04040	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I7831_RS04050	COG1464	Belongs to the NlpA lipoprotein family
I7831_RS04055	COG0039	L-malate dehydrogenase activity
I7831_RS04065	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I7831_RS04070	COG0626	cystathionine gamma-synthase activity
I7831_RS04095	COG0829	nickel cation binding
I7831_RS04100	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I7831_RS04105	COG0830	nickel cation binding
I7831_RS04110	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
I7831_RS04115	COG0804	urea catabolic process
I7831_RS04120	COG0832	Belongs to the urease beta subunit family
I7831_RS04125	COG0831	urea catabolic process
I7831_RS04130	COG4413	Urea transporter
I7831_RS04135	COG0747	negative chemotaxis
I7831_RS04160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I7831_RS04170	COG0531	amino acid
I7831_RS04180	COG0561	phosphatase activity
I7831_RS04190	COG0167	dihydroorotate dehydrogenase activity
I7831_RS04195	COG3001	Fructosamine kinase
I7831_RS04220	COG0697	spore germination
I7831_RS04225	COG1113	amino acid transport
I7831_RS04245	COG3189	MarR family transcriptional regulator
I7831_RS04260	COG1388	LysM domain
I7831_RS04265	COG0436	Aminotransferase
I7831_RS04275	COG2608	mercury ion transmembrane transporter activity
I7831_RS04280	COG2217	Heavy metal translocating P-type atpase
I7831_RS04285	COG0659	secondary active sulfate transmembrane transporter activity
I7831_RS04290	COG1136	(ABC) transporter
I7831_RS04295	COG0577	efflux transmembrane transporter activity
I7831_RS04300	COG1028	Short-chain dehydrogenase reductase Sdr
I7831_RS04315	COG0471	metal ion transport
I7831_RS04320	COG5505	Protein of unknown function (DUF819)
I7831_RS04335	COG4336	lyase activity
I7831_RS04345	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
I7831_RS04350	COG1012	belongs to the aldehyde dehydrogenase family
I7831_RS04360	COG2409	Drug exporters of the RND superfamily
I7831_RS04375	COG1473	amidohydrolase
I7831_RS04400	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I7831_RS04405	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I7831_RS04410	COG3425	synthase
I7831_RS04425	COG3386	PFAM SMP-30 Gluconolaconase
I7831_RS04430	COG3942	CHAP domain
I7831_RS04435	COG1757	Na H antiporter
I7831_RS04440	COG0583	DNA-binding transcription factor activity
I7831_RS04445	COG1380	Effector of murein hydrolase LrgA
I7831_RS04450	COG1346	cytolysis
I7831_RS04455	COG0028	Belongs to the TPP enzyme family
I7831_RS04460	COG1288	antiporter activity
I7831_RS04465	COG1263	PTS System
I7831_RS04465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7831_RS04465	COG2190	(PTS) system
I7831_RS04475	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I7831_RS04485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I7831_RS04500	COG0697	spore germination
I7831_RS04520	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I7831_RS04530	COG2843	Capsule synthesis protein
I7831_RS04550	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I7831_RS04555	COG1063	alcohol dehydrogenase
I7831_RS04560	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I7831_RS04580	COG1129	ABC transporter
I7831_RS04600	COG1070	Carbohydrate kinase
I7831_RS04605	COG1063	alcohol dehydrogenase
I7831_RS04615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I7831_RS04625	COG3764	Sortase (surface protein transpeptidase)
I7831_RS04630	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I7831_RS04635	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I7831_RS04660	COG1476	TRANSCRIPTIONal
I7831_RS04665	COG2249	NAD(P)H dehydrogenase (quinone) activity
I7831_RS04670	COG0561	phosphatase activity
I7831_RS04690	COG2723	6-phospho-beta-galactosidase activity
I7831_RS04695	COG3711	transcriptional antiterminator
I7831_RS04700	COG2514	catechol 2,3-dioxygenase activity
I7831_RS04710	COG1132	(ABC) transporter
I7831_RS04715	COG1132	(ABC) transporter
I7831_RS04735	COG1846	Transcriptional regulator
I7831_RS04740	COG0346	lactoylglutathione lyase activity
I7831_RS04745	COG0346	lactoylglutathione lyase activity
I7831_RS04750	COG0400	carboxylic ester hydrolase activity
I7831_RS04760	COG0471	metal ion transport
I7831_RS04765	COG3949	Membrane
I7831_RS04775	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
I7831_RS04780	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I7831_RS04785	COG0586	Pfam SNARE associated Golgi protein
I7831_RS04790	COG2271	Major facilitator Superfamily
I7831_RS04800	COG1289	transmembrane transporter activity
I7831_RS04815	COG4876	unkown
I7831_RS04820	COG2357	RelA SpoT domain protein
I7831_RS04830	COG1802	Transcriptional regulator
I7831_RS04840	COG2610	gluconate transmembrane transporter activity
I7831_RS04845	COG1028	Short-chain dehydrogenase reductase Sdr
I7831_RS04850	COG3949	Membrane
I7831_RS04870	COG4221	oxidoreductase activity
I7831_RS04895	COG0107	imidazoleglycerol-phosphate synthase activity
I7831_RS04900	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I7831_RS04905	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I7831_RS04910	COG0131	Imidazoleglycerol-phosphate dehydratase
I7831_RS04915	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I7831_RS04920	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I7831_RS04925	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I7831_RS04930	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I7831_RS04935	COG3048	D-serine ammonia-lyase activity
I7831_RS04940	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I7831_RS04945	COG0248	Ppx GppA phosphatase
I7831_RS04950	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I7831_RS04955	COG1028	Short-chain dehydrogenase reductase Sdr
I7831_RS04960	COG1363	Peptidase, m42
I7831_RS04970	COG0069	glutamate synthase activity
I7831_RS04980	COG4619	ABC transporter
I7831_RS04985	COG0390	transport system, permease component
I7831_RS04990	COG2814	Major facilitator Superfamily
I7831_RS04995	COG0531	amino acid
I7831_RS05000	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
I7831_RS05010	COG3246	L-lysine catabolic process to acetate
I7831_RS05015	COG1250	3-hydroxyacyl-CoA dehydrogenase
I7831_RS05030	COG1174	glycine betaine transport
I7831_RS05040	COG1174	glycine betaine transport
I7831_RS05050	COG1960	acyl-CoA dehydrogenase activity
I7831_RS05055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I7831_RS05065	COG1116	anion transmembrane transporter activity
I7831_RS05075	COG1346	cytolysis
I7831_RS05080	COG1380	Effector of murein hydrolase LrgA
I7831_RS05085	COG3279	Response regulator of the LytR AlgR family
I7831_RS05090	COG3275	phosphorelay sensor kinase activity
I7831_RS05120	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I7831_RS05155	COG2814	Major facilitator Superfamily
I7831_RS05165	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I7831_RS05170	COG1388	LysM domain
I7831_RS05175	COG0588	phosphoglycerate mutase activity
I7831_RS05185	COG2814	Major facilitator Superfamily
I7831_RS05210	COG3443	Belongs to the bacterial solute-binding protein 9 family
I7831_RS05210	COG0803	Belongs to the bacterial solute-binding protein 9 family
I7831_RS05215	COG2353	YceI-like domain
I7831_RS05225	COG1695	Transcriptional regulator
I7831_RS05250	COG1959	2 iron, 2 sulfur cluster binding
I7831_RS05255	COG2116	formate transmembrane transporter activity
I7831_RS05260	COG0454	-acetyltransferase
I7831_RS05275	COG0071	Belongs to the small heat shock protein (HSP20) family
I7831_RS05285	COG1846	Transcriptional regulator
I7831_RS05295	COG1301	dicarboxylic acid transport
I7831_RS05305	COG2207	Transcriptional regulator
I7831_RS05315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7831_RS05315	COG1263	PTS System
I7831_RS05335	COG1283	sodium-dependent phosphate transmembrane transporter activity
I7831_RS05340	COG1028	Short-chain dehydrogenase reductase Sdr
I7831_RS05345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I7831_RS05350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I7831_RS05355	COG1288	antiporter activity
I7831_RS05360	COG1349	DNA-binding transcription factor activity
I7831_RS05365	COG1063	alcohol dehydrogenase
I7831_RS05370	COG2376	Dihydroxyacetone kinase
I7831_RS05380	COG0698	ribose 5-phosphate isomerase
I7831_RS05390	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I7831_RS05395	COG0492	ferredoxin-NADP+ reductase activity
I7831_RS05405	COG2814	Major facilitator Superfamily
I7831_RS05410	COG0604	alcohol dehydrogenase
I7831_RS05425	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I7831_RS05425	COG0463	Glycosyl transferase, family 2
I7831_RS05430	COG1620	l-lactate permease
I7831_RS05435	COG0438	transferase activity, transferring glycosyl groups
I7831_RS05445	COG5002	protein histidine kinase activity
I7831_RS05445	COG3850	Histidine kinase
I7831_RS05450	COG0745	RESPONSE REGULATOR receiver
I7831_RS05455	COG0577	efflux transmembrane transporter activity
I7831_RS05460	COG1136	(ABC) transporter
I7831_RS05475	COG4640	response to antibiotic
I7831_RS05480	COG2814	Major facilitator Superfamily
I7831_RS05490	COG1566	PFAM secretion protein HlyD family protein
I7831_RS05495	COG2814	Major facilitator Superfamily
I7831_RS05520	COG0598	Magnesium transport protein CorA
I7831_RS05525	COG1304	FMN binding
I7831_RS05530	COG0786	glutamate:sodium symporter activity
I7831_RS05535	COG1695	Transcriptional regulator
I7831_RS05550	COG1757	Na H antiporter
I7831_RS05555	COG2094	Belongs to the DNA glycosylase MPG family
I7831_RS05560	COG3152	Membrane
I7831_RS05565	COG1069	ribulokinase activity
I7831_RS05570	COG4152	abc transporter atp-binding protein
I7831_RS05575	COG1668	transmembrane transport
I7831_RS05580	COG2017	converts alpha-aldose to the beta-anomer
I7831_RS05585	COG2258	MOSC domain
I7831_RS05590	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I7831_RS05595	COG1266	CAAX protease self-immunity
I7831_RS05600	COG0010	Belongs to the arginase family
I7831_RS05605	COG0583	DNA-binding transcription factor activity
I7831_RS05610	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I7831_RS05615	COG1228	amidohydrolase
I7831_RS05620	COG0659	secondary active sulfate transmembrane transporter activity
I7831_RS05625	COG1473	amidohydrolase
I7831_RS05630	COG1028	Short-chain dehydrogenase reductase Sdr
I7831_RS05635	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I7831_RS05655	COG1263	PTS System
I7831_RS05655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7831_RS05665	COG0385	Bile acid
I7831_RS05670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I7831_RS05695	COG1113	amino acid transport
I7831_RS05700	COG1785	Belongs to the alkaline phosphatase family
I7831_RS05705	COG1737	Transcriptional regulator
I7831_RS05710	COG1263	PTS System
I7831_RS05710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7831_RS05715	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I7831_RS05735	COG0483	inositol monophosphate 1-phosphatase activity
I7831_RS05740	COG1316	TRANSCRIPTIONal
I7831_RS05745	COG3383	formate dehydrogenase (NAD+) activity
I7831_RS05760	COG4193	domain, Protein
I7831_RS05770	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I7831_RS05775	COG2076	Multidrug Resistance protein
I7831_RS05780	COG2076	Multidrug Resistance protein
I7831_RS05785	COG3942	CHAP domain
I7831_RS05800	COG1757	Na H antiporter
I7831_RS05805	COG3942	CHAP domain
I7831_RS05835	COG0765	amino acid transport
I7831_RS05840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I7831_RS05845	COG1126	abc transporter atp-binding protein
I7831_RS05850	COG1960	acyl-CoA dehydrogenase activity
I7831_RS05855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I7831_RS05860	COG1268	BioY protein
I7831_RS05870	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I7831_RS05875	COG1609	Transcriptional regulator
I7831_RS05880	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I7831_RS05885	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I7831_RS05890	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I7831_RS05895	COG0725	ABC transporter, periplasmic molybdate-binding protein
I7831_RS05900	COG4149	molybdate abc transporter
I7831_RS05915	COG1510	regulation of RNA biosynthetic process
I7831_RS05920	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I7831_RS05925	COG0521	Mo-molybdopterin cofactor biosynthetic process
I7831_RS05930	COG0315	cyclic pyranopterin monophosphate synthase activity
I7831_RS05955	COG0746	molybdenum cofactor guanylyltransferase activity
I7831_RS05960	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I7831_RS05990	COG2348	transferase activity, transferring amino-acyl groups
I7831_RS05995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I7831_RS06020	COG4975	Glucose uptake
I7831_RS06030	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I7831_RS06030	COG0551	DNA topoisomerase type I activity
I7831_RS06035	COG2252	PERMEase
I7831_RS06045	COG0051	transcription antitermination factor activity, RNA binding
I7831_RS06050	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I7831_RS06055	COG0088	Forms part of the polypeptide exit tunnel
I7831_RS06060	COG0089	rRNA binding
I7831_RS06065	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I7831_RS06070	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I7831_RS06075	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I7831_RS06080	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I7831_RS06085	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I7831_RS06090	COG0255	Belongs to the universal ribosomal protein uL29 family
I7831_RS06095	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I7831_RS06100	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I7831_RS06105	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I7831_RS06110	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I7831_RS06115	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I7831_RS06120	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I7831_RS06125	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I7831_RS06130	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I7831_RS06135	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I7831_RS06140	COG1841	ribosomal large subunit assembly
I7831_RS06145	COG0200	Binds to the 23S rRNA
I7831_RS06150	COG0201	protein transport
I7831_RS06155	COG0563	adenylate kinase activity
I7831_RS06165	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I7831_RS06170	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I7831_RS06175	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I7831_RS06180	COG0202	RNA polymerase activity
I7831_RS06185	COG0203	ribosomal protein L17
I7831_RS06190	COG1122	ATPase activity
I7831_RS06195	COG1122	ATPase activity
I7831_RS06205	COG0101	tRNA pseudouridine synthase activity
I7831_RS06210	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I7831_RS06215	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I7831_RS06225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I7831_RS06230	COG2130	NADP-dependent
I7831_RS06235	COG0604	alcohol dehydrogenase
I7831_RS06240	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I7831_RS06255	COG1302	Protein conserved in bacteria
I7831_RS06260	COG4264	IucA IucC family
I7831_RS06265	COG2814	Major facilitator Superfamily
I7831_RS06270	COG4264	IucA IucC family
I7831_RS06275	COG3457	Alanine racemase
I7831_RS06280	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I7831_RS06285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I7831_RS06290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I7831_RS06295	COG3314	Sporulation integral membrane protein YlbJ
I7831_RS06310	COG1988	membrane-bound metal-dependent
I7831_RS06315	COG4284	Utp--glucose-1-phosphate uridylyltransferase
I7831_RS06320	COG1272	protein, Hemolysin III
I7831_RS06335	COG0489	protein tyrosine kinase activity
I7831_RS06390	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I7831_RS06400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I7831_RS06405	COG0246	Mannitol dehydrogenase
I7831_RS06415	COG3711	transcriptional antiterminator
I7831_RS06420	COG2213	PTS system mannitol-specific
I7831_RS06435	COG1119	ATPase activity
I7831_RS06460	COG0640	Transcriptional regulator
I7831_RS06465	COG0702	epimerase
I7831_RS06470	COG2186	Transcriptional regulator
I7831_RS06475	COG1482	cell wall glycoprotein biosynthetic process
I7831_RS06485	COG2855	membrane
I7831_RS06500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I7831_RS06505	COG0783	Belongs to the Dps family
I7831_RS06510	COG0813	purine-nucleoside phosphorylase activity
I7831_RS06515	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I7831_RS06520	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I7831_RS06525	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I7831_RS06535	COG1854	S-ribosylhomocysteine lyase activity
I7831_RS06555	COG5146	pantothenate kinase activity
I7831_RS06560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I7831_RS06565	COG3343	RNA polymerase activity
I7831_RS06570	COG0504	CTP synthase activity
I7831_RS06575	COG0191	fructose-bisphosphate aldolase activity
I7831_RS06580	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I7831_RS06590	COG1012	belongs to the aldehyde dehydrogenase family
I7831_RS06595	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I7831_RS06600	COG0254	rRNA binding
I7831_RS06605	COG1435	thymidine kinase activity
I7831_RS06610	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I7831_RS06615	COG2890	protein-(glutamine-N5) methyltransferase activity
I7831_RS06620	COG0009	L-threonylcarbamoyladenylate synthase
I7831_RS06625	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I7831_RS06630	COG4475	Protein of unknown function (DUF436)
I7831_RS06635	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I7831_RS06640	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I7831_RS06645	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I7831_RS06655	COG0356	it plays a direct role in the translocation of protons across the membrane
I7831_RS06660	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I7831_RS06665	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I7831_RS06670	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I7831_RS06675	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I7831_RS06680	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I7831_RS06685	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I7831_RS06690	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I7831_RS06700	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I7831_RS06705	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I7831_RS06715	COG0629	single-stranded DNA binding
I7831_RS06720	COG1388	LysM domain
I7831_RS06725	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I7831_RS06735	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I7831_RS06740	COG0352	thiamine-phosphate diphosphorylase activity
I7831_RS06745	COG0706	membrane insertase activity
I7831_RS06750	COG1418	mRNA catabolic process
I7831_RS06760	COG1937	Protein conserved in bacteria
I7831_RS06775	COG0772	Belongs to the SEDS family
I7831_RS06780	COG1181	Belongs to the D-alanine--D-alanine ligase family
I7831_RS06785	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I7831_RS06790	COG0513	Belongs to the DEAD box helicase family
I7831_RS06800	COG3428	Bacterial PH domain
I7831_RS06805	COG3402	PFAM membrane-flanked domain
I7831_RS06810	COG0736	holo-[acyl-carrier-protein] synthase activity
I7831_RS06815	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I7831_RS06825	COG2337	Toxic component of a toxin-antitoxin (TA) module
I7831_RS06830	COG2208	phosphoserine phosphatase activity
I7831_RS06845	COG1191	sigma factor activity
I7831_RS06850	COG2183	response to ionizing radiation
I7831_RS06855	COG3091	SprT-like family
I7831_RS06885	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I7831_RS06890	COG0066	3-isopropylmalate dehydratase activity
I7831_RS06895	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I7831_RS06900	COG0473	3-isopropylmalate dehydrogenase activity
I7831_RS06905	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I7831_RS06910	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I7831_RS06915	COG0440	acetolactate synthase activity
I7831_RS06920	COG0028	Belongs to the TPP enzyme family
I7831_RS06925	COG0129	dihydroxy-acid dehydratase activity
I7831_RS06930	COG0802	atpase or kinase
I7831_RS06935	COG1214	PFAM Peptidase M22, glycoprotease
I7831_RS06940	COG0456	acetyltransferase
I7831_RS06945	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I7831_RS06955	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I7831_RS06960	COG0488	(ABC) transporter
I7831_RS06965	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I7831_RS06970	COG2391	methyltransferase activity
I7831_RS06975	COG0425	Belongs to the sulfur carrier protein TusA family
I7831_RS06980	COG1609	Transcriptional regulator
I7831_RS06985	COG1621	beta-fructofuranosidase activity
I7831_RS06990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I7831_RS06995	COG3279	Response regulator of the LytR AlgR family
I7831_RS07010	COG4512	PFAM Accessory gene regulator B
I7831_RS07015	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I7831_RS07035	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I7831_RS07040	COG0459	protein refolding
I7831_RS07075	COG1725	Transcriptional regulator
I7831_RS07090	COG1131	(ABC) transporter
I7831_RS07135	COG2706	6-phosphogluconolactonase activity
I7831_RS07145	COG1012	belongs to the aldehyde dehydrogenase family
I7831_RS07150	COG1227	inorganic diphosphatase activity
I7831_RS07155	COG1335	isochorismatase
I7831_RS07165	COG0471	metal ion transport
I7831_RS07170	COG0077	Prephenate dehydratase
I7831_RS07180	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I7831_RS07185	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I7831_RS07190	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
I7831_RS07200	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I7831_RS07205	COG4496	protein, YerC YecD
I7831_RS07215	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
I7831_RS07225	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I7831_RS07230	COG4851	CamS sex pheromone cAM373 precursor
I7831_RS07235	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I7831_RS07240	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I7831_RS07245	COG0154	amidase activity
I7831_RS07250	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I7831_RS07255	COG1597	lipid kinase activity
I7831_RS07260	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I7831_RS07270	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I7831_RS07280	COG1528	Iron-storage protein
I7831_RS07295	COG4129	membrane
I7831_RS07300	COG0024	Methionine aminopeptidase
I7831_RS07315	COG4585	Histidine kinase
I7831_RS07320	COG2197	response regulator
I7831_RS07325	COG1295	ribonuclease BN
I7831_RS07335	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I7831_RS07340	COG4840	Belongs to the UPF0435 family
I7831_RS07345	COG2309	aminopeptidase activity
I7831_RS07350	COG1607	acyl-coa hydrolase
I7831_RS07355	COG0535	radical SAM domain protein
I7831_RS07365	COG0693	protein deglycase activity
I7831_RS07370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I7831_RS07375	COG2137	regulation of response to DNA damage stimulus
I7831_RS07385	COG1134	teichoic acid transport
I7831_RS07395	COG1988	membrane-bound metal-dependent
I7831_RS07405	COG3557	Belongs to the UPF0374 family
I7831_RS07415	COG4129	membrane
I7831_RS07420	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I7831_RS07425	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I7831_RS07430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I7831_RS07435	COG0735	belongs to the Fur family
I7831_RS07590	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I7831_RS07605	COG0765	amino acid transport
I7831_RS07610	COG1126	abc transporter atp-binding protein
I7831_RS07615	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I7831_RS07625	COG0363	glucosamine-6-phosphate deaminase activity
I7831_RS07640	COG0114	fumarate hydratase activity
I7831_RS07645	COG0564	pseudouridine synthase activity
I7831_RS07650	COG2203	Gaf domain
I7831_RS07650	COG4585	Histidine kinase
I7831_RS07660	COG1301	dicarboxylic acid transport
I7831_RS07670	COG1682	transport, permease protein
I7831_RS07675	COG0788	formyltetrahydrofolate deformylase activity
I7831_RS07685	COG4399	Belongs to the UPF0754 family
I7831_RS07690	COG3679	Belongs to the UPF0342 family
I7831_RS07695	COG0420	3'-5' exonuclease activity
I7831_RS07700	COG4717	serine-type aminopeptidase activity
I7831_RS07705	COG3481	metal-dependent phosphohydrolase, HD sub domain
I7831_RS07710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I7831_RS07725	COG0537	adenosine 5'-monophosphoramidase activity
I7831_RS07730	COG1131	(ABC) transporter
I7831_RS07735	COG4473	ABC transporter
I7831_RS07745	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I7831_RS07750	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I7831_RS07755	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I7831_RS07760	COG3545	Serine hydrolase
I7831_RS07810	COG0318	PFAM AMP-dependent synthetase and ligase
I7831_RS07820	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I7831_RS07830	COG1506	peptidase
I7831_RS07835	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I7831_RS07840	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I7831_RS07850	COG0656	L-ascorbic acid biosynthetic process
I7831_RS07855	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I7831_RS07860	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I7831_RS07870	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I7831_RS07900	COG3266	domain, Protein
I7831_RS07900	COG4193	domain, Protein
I7831_RS07900	COG5632	N-Acetylmuramoyl-L-alanine amidase
I7831_RS07915	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I7831_RS07915	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I7831_RS07920	COG0307	riboflavin synthase, alpha
I7831_RS07925	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I7831_RS07925	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I7831_RS07930	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I7831_RS07935	COG0506	proline dehydrogenase activity
I7831_RS07940	COG2267	carboxylic ester hydrolase activity
I7831_RS07945	COG0039	L-malate dehydrogenase activity
I7831_RS07955	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I7831_RS07960	COG1242	4 iron, 4 sulfur cluster binding
I7831_RS07965	COG2814	Major facilitator Superfamily
I7831_RS07970	COG0495	leucyl-tRNA aminoacylation
I7831_RS07980	COG2081	HI0933 family
I7831_RS07985	COG2244	polysaccharide biosynthetic process
I7831_RS07990	COG1187	pseudouridine synthase activity
I7831_RS08000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I7831_RS08005	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I7831_RS08010	COG0510	thiamine kinase activity
I7831_RS08015	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I7831_RS08020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I7831_RS08025	COG5584	Small secreted protein
I7831_RS08030	COG1363	Peptidase, m42
I7831_RS08035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I7831_RS08040	COG4848	Belongs to the UPF0354 family
I7831_RS08045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I7831_RS08050	COG1674	ftsk spoiiie
I7831_RS08055	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I7831_RS08060	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
I7831_RS08070	COG1605	Chorismate mutase
I7831_RS08070	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I7831_RS08075	COG1609	Transcriptional regulator
I7831_RS08080	COG0123	including yeast histone deacetylase and acetoin utilization protein
I7831_RS08085	COG0454	-acetyltransferase
I7831_RS08090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I7831_RS08095	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I7831_RS08100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I7831_RS08105	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I7831_RS08110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I7831_RS08115	COG0204	Acyl-transferase
I7831_RS08120	COG1263	PTS System
I7831_RS08120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7831_RS08130	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I7831_RS08140	COG1764	response to oxidative stress
I7831_RS08145	COG0584	glycerophosphoryl diester phosphodiesterase
I7831_RS08155	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I7831_RS08160	COG1956	GAF domain-containing protein
I7831_RS08165	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I7831_RS08170	COG1104	cysteine desulfurase activity
I7831_RS08175	COG0301	tRNA thio-modification
I7831_RS08185	COG0616	signal peptide processing
I7831_RS08190	COG1714	RDD family
I7831_RS08195	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I7831_RS08200	COG0827	DNA restriction-modification system
I7831_RS08205	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I7831_RS08220	COG0589	response to stress
I7831_RS08225	COG0686	Belongs to the AlaDH PNT family
I7831_RS08230	COG3142	Participates in the control of copper homeostasis
I7831_RS08235	COG0006	proline dipeptidase activity
I7831_RS08240	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I7831_RS08250	COG4109	DRTGG domain
I7831_RS08255	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I7831_RS08260	COG0587	DNA-directed DNA polymerase activity
I7831_RS08265	COG0281	malic enzyme
I7831_RS08270	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I7831_RS08275	COG0825	malonyl-CoA metabolic process
I7831_RS08280	COG0205	6-phosphofructokinase activity
I7831_RS08285	COG0469	pyruvate kinase activity
I7831_RS08290	COG1113	amino acid transport
I7831_RS08295	COG0372	Belongs to the citrate synthase family
I7831_RS08300	COG0538	isocitrate dehydrogenase activity
I7831_RS08305	COG0745	RESPONSE REGULATOR receiver
I7831_RS08310	COG5002	protein histidine kinase activity
I7831_RS08315	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I7831_RS08315	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I7831_RS08320	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I7831_RS08325	COG0237	dephospho-CoA kinase activity
I7831_RS08330	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I7831_RS08335	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I7831_RS08345	COG1484	DNA-dependent DNA replication
I7831_RS08350	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I7831_RS08355	COG0833	amino acid
I7831_RS08360	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I7831_RS08365	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I7831_RS08370	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I7831_RS08375	COG4112	unkown
I7831_RS08385	COG0544	peptidyl-prolyl cis-trans isomerase activity
I7831_RS08390	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I7831_RS08395	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I7831_RS08400	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I7831_RS08405	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I7831_RS08410	COG0181	hydroxymethylbilane synthase activity
I7831_RS08420	COG0113	porphobilinogen synthase activity
I7831_RS08425	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I7831_RS08440	COG2818	Glycosylase
I7831_RS08445	COG0525	valine-tRNA ligase activity
I7831_RS08450	COG0285	dihydrofolate synthase activity
I7831_RS08460	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I7831_RS08485	COG2249	NAD(P)H dehydrogenase (quinone) activity
I7831_RS08490	COG0477	Major facilitator Superfamily
I7831_RS08535	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I7831_RS08540	COG2868	ribosomal protein
I7831_RS08545	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I7831_RS08550	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I7831_RS08555	COG4492	Belongs to the UPF0735 family
I7831_RS08560	COG0632	four-way junction helicase activity
I7831_RS08565	COG2255	four-way junction helicase activity
I7831_RS08570	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I7831_RS08575	COG0343	queuine tRNA-ribosyltransferase activity
I7831_RS08580	COG1862	Preprotein translocase
I7831_RS08585	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I7831_RS08585	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I7831_RS08590	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I7831_RS08590	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I7831_RS08595	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I7831_RS08605	COG1490	D-aminoacyl-tRNA deacylase activity
I7831_RS08610	COG0860	N-Acetylmuramoyl-L-alanine amidase
I7831_RS08615	COG0124	histidyl-tRNA synthetase
I7831_RS08620	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I7831_RS08630	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I7831_RS08635	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I7831_RS08640	COG1959	2 iron, 2 sulfur cluster binding
I7831_RS08645	COG3237	CsbD-like
I7831_RS08655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I7831_RS08660	COG0488	(ABC) transporter
I7831_RS08665	COG1104	cysteine desulfurase activity
I7831_RS08670	COG0482	sulfurtransferase activity
I7831_RS08680	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I7831_RS08685	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I7831_RS08690	COG4472	Bacterial protein of unknown function (DUF965)
I7831_RS08695	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I7831_RS08700	COG3906	Belongs to the UPF0473 family
I7831_RS08705	COG4122	O-methyltransferase activity
I7831_RS08710	COG0826	peptidase U32
I7831_RS08715	COG0826	peptidase U32
I7831_RS08720	COG0572	uridine kinase
I7831_RS08725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I7831_RS08730	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I7831_RS08735	COG1984	allophanate hydrolase subunit 2
I7831_RS08745	COG0439	Biotin carboxylase
I7831_RS08750	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I7831_RS08755	COG1914	H( )-stimulated, divalent metal cation uptake system
I7831_RS08760	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I7831_RS08765	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I7831_RS08770	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I7831_RS08775	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I7831_RS08780	COG1534	Rna-binding protein
I7831_RS08785	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I7831_RS08790	COG1713	HD superfamily hydrolase involved in NAD metabolism
I7831_RS08795	COG0799	negative regulation of ribosome biogenesis
I7831_RS08800	COG2226	methyltransferase
I7831_RS08805	COG1555	photosystem II stabilization
I7831_RS08805	COG1596	polysaccharide export
I7831_RS08810	COG2131	deaminase
I7831_RS08815	COG0658	competence protein
I7831_RS08815	COG2333	competence protein COMEC
I7831_RS08820	COG1466	dna polymerase III delta subunit
I7831_RS08825	COG0268	Binds directly to 16S ribosomal RNA
I7831_RS08830	COG0481	GTPase activity
I7831_RS08835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I7831_RS08840	COG1420	regulation of RNA biosynthetic process
I7831_RS08845	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I7831_RS08850	COG0443	Heat shock 70 kDa protein
I7831_RS08855	COG0484	heat shock protein binding
I7831_RS08860	COG2264	protein methyltransferase activity
I7831_RS08865	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I7831_RS08870	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I7831_RS08875	COG1030	water channel activity
I7831_RS08880	COG4864	UPF0365 protein
I7831_RS08890	COG1702	phosphate starvation-inducible protein PhoH
I7831_RS08895	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I7831_RS08905	COG0295	cytidine deaminase activity
I7831_RS08910	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I7831_RS08915	COG1381	Involved in DNA repair and RecF pathway recombination
I7831_RS08920	COG0423	glycine-tRNA ligase activity
I7831_RS08925	COG0517	IMP dehydrogenase activity
I7831_RS08930	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I7831_RS08940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I7831_RS08945	COG2384	SAM-dependent methyltransferase
I7831_RS08950	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I7831_RS08955	COG0513	Belongs to the DEAD box helicase family
I7831_RS08960	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I7831_RS08965	COG1121	(ABC) transporter
I7831_RS08970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I7831_RS08980	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I7831_RS08985	COG0768	penicillin binding
I7831_RS08990	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I7831_RS08995	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I7831_RS09000	COG0705	Rhomboid family
I7831_RS09000	COG0457	Tetratricopeptide repeat
I7831_RS09005	COG4483	Protein conserved in bacteria
I7831_RS09010	COG1940	carbohydrate kinase activity
I7831_RS09015	COG0011	TIGRFAM Protein of
I7831_RS09020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I7831_RS09025	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I7831_RS09030	COG1459	type II secretion system
I7831_RS09035	COG4537	Required for transformation and DNA binding
I7831_RS09050	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I7831_RS09055	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I7831_RS09060	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I7831_RS09065	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I7831_RS09070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I7831_RS09075	COG0095	Lipoate-protein ligase
I7831_RS09090	COG0006	proline dipeptidase activity
I7831_RS09095	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I7831_RS09100	COG0511	ligase activity, forming carbon-carbon bonds
I7831_RS09105	COG0439	Biotin carboxylase
I7831_RS09110	COG1302	Protein conserved in bacteria
I7831_RS09115	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I7831_RS09120	COG1570	exodeoxyribonuclease VII activity
I7831_RS09125	COG1722	exodeoxyribonuclease VII activity
I7831_RS09140	COG1438	arginine binding
I7831_RS09145	COG0497	DNA recombination
I7831_RS09150	COG0280	phosphate acetyltransferase
I7831_RS09155	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I7831_RS09160	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I7831_RS09165	COG0022	dehydrogenase e1 component
I7831_RS09170	COG0508	dehydrogenase complex catalyzes the overall conversion of
I7831_RS09180	COG4129	membrane
I7831_RS09190	COG2195	Cleaves the N-terminal amino acid of tripeptides
I7831_RS09200	COG1609	Transcriptional regulator
I7831_RS09205	COG0366	Alpha amylase catalytic
I7831_RS09215	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I7831_RS09220	COG1234	tRNA 3'-trailer cleavage
I7831_RS09225	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I7831_RS09235	COG0667	Aldo Keto reductase
I7831_RS09240	COG0494	nUDIX hydrolase
I7831_RS09245	COG0735	belongs to the Fur family
I7831_RS09250	COG4974	Belongs to the 'phage' integrase family
I7831_RS09260	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I7831_RS09265	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I7831_RS09270	COG1187	pseudouridine synthase activity
I7831_RS09275	COG0745	RESPONSE REGULATOR receiver
I7831_RS09290	COG1141	Ferredoxin
I7831_RS09300	COG0514	ATP-dependent DNA helicase (RecQ)
I7831_RS09305	COG1388	LysM domain
I7831_RS09310	COG0492	ferredoxin-NADP+ reductase activity
I7831_RS09320	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I7831_RS09325	COG0539	negative regulation of cytoplasmic translation
I7831_RS09330	COG1160	GTP binding
I7831_RS09335	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I7831_RS09350	COG2226	methyltransferase
I7831_RS09355	COG0142	geranyltranstransferase activity
I7831_RS09360	COG0105	UTP biosynthetic process
I7831_RS09365	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I7831_RS09370	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I7831_RS09375	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I7831_RS09390	COG4347	Protein of unknown function (DUF1405)
I7831_RS09395	COG2738	Putative neutral zinc metallopeptidase
I7831_RS09400	COG1694	Mazg nucleotide pyrophosphohydrolase
I7831_RS09405	COG0438	transferase activity, transferring glycosyl groups
I7831_RS09410	COG0617	tRNA 3'-terminal CCA addition
I7831_RS09415	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I7831_RS09415	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I7831_RS09420	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I7831_RS09420	COG1199	ATP-dependent helicase activity
I7831_RS09425	COG0017	Asparaginyl-tRNA synthetase
I7831_RS09430	COG3935	DnaD domain protein
I7831_RS09435	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I7831_RS09445	COG4499	WXG100 protein secretion system (Wss), protein YukC
I7831_RS09445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I7831_RS09450	COG3331	DNA recombination
I7831_RS09460	COG4474	Belongs to the UPF0398 family
I7831_RS09465	COG3599	regulation of cell shape
I7831_RS09475	COG0116	Belongs to the methyltransferase superfamily
I7831_RS09480	COG2962	Rard protein
I7831_RS09495	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I7831_RS09500	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I7831_RS09505	COG0328	RNA-DNA hybrid ribonuclease activity
I7831_RS09510	COG3545	Serine hydrolase
I7831_RS09515	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I7831_RS09525	COG1413	lyase activity
I7831_RS09530	COG1413	lyase activity
I7831_RS09540	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I7831_RS09560	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I7831_RS09570	COG4479	Belongs to the UPF0346 family
I7831_RS09575	COG0793	Belongs to the peptidase S41A family
I7831_RS09585	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I7831_RS09590	COG0671	phosphoesterase, PA-phosphatase related
I7831_RS09595	COG0745	RESPONSE REGULATOR receiver
I7831_RS09600	COG5002	protein histidine kinase activity
I7831_RS09605	COG0567	Dehydrogenase, E1 component
I7831_RS09610	COG0508	dehydrogenase complex catalyzes the overall conversion of
I7831_RS09635	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I7831_RS09640	COG1121	(ABC) transporter
I7831_RS09660	COG0714	Associated with various cellular activities
I7831_RS09665	COG4548	von Willebrand factor, type A
I7831_RS09670	COG1114	Component of the transport system for branched-chain amino acids
I7831_RS09675	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I7831_RS09680	COG3853	Toxic anion resistance protein (TelA)
I7831_RS09690	COG1254	Belongs to the acylphosphatase family
I7831_RS09700	COG1278	Cold shock
I7831_RS09715	COG1473	amidohydrolase
I7831_RS09720	COG2171	N-acyltransferase activity
I7831_RS09725	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I7831_RS09730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I7831_RS09735	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I7831_RS09740	COG0527	aspartate kinase activity
I7831_RS09750	COG0488	(ABC) transporter
I7831_RS09755	COG2996	Protein conserved in bacteria
I7831_RS09760	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I7831_RS09765	COG0573	inorganic phosphate transmembrane transporter activity
I7831_RS09770	COG0581	inorganic phosphate transmembrane transporter activity
I7831_RS09775	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I7831_RS09780	COG0704	Plays a role in the regulation of phosphate uptake
I7831_RS09785	COG1164	Oligoendopeptidase f
I7831_RS09795	COG4607	ABC-type enterochelin transport system periplasmic component
I7831_RS09805	COG2348	transferase activity, transferring amino-acyl groups
I7831_RS09810	COG2348	transferase activity, transferring amino-acyl groups
I7831_RS09820	COG0159	tryptophan synthase activity
I7831_RS09825	COG0133	tryptophan synthase activity
I7831_RS09830	COG0135	phosphoribosylanthranilate isomerase activity
I7831_RS09835	COG0134	indole-3-glycerol-phosphate synthase activity
I7831_RS09840	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I7831_RS09845	COG0512	Glutamine amidotransferase of anthranilate synthase
I7831_RS09850	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I7831_RS09860	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I7831_RS09865	COG1363	Peptidase, m42
I7831_RS09880	COG0287	Prephenate dehydrogenase
I7831_RS09885	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I7831_RS09890	COG1942	4-Oxalocrotonate Tautomerase
I7831_RS09905	COG1879	ABC-type sugar transport system periplasmic component
I7831_RS09910	COG1172	Belongs to the binding-protein-dependent transport system permease family
I7831_RS09915	COG1129	ABC transporter
I7831_RS09920	COG1869	D-ribose catabolic process
I7831_RS09925	COG1609	Transcriptional regulator
I7831_RS09930	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I7831_RS09930	COG0392	lysyltransferase activity
I7831_RS09935	COG0628	permease
I7831_RS09950	COG3711	transcriptional antiterminator
I7831_RS09955	COG1115	amino acid carrier protein
I7831_RS09960	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I7831_RS09970	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I7831_RS09975	COG4841	protein insertion into membrane
I7831_RS09980	COG0824	Thioesterase
I7831_RS09985	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I7831_RS09990	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I7831_RS09995	COG1970	mechanosensitive ion channel activity
I7831_RS10000	COG0419	ATPase involved in DNA repair
I7831_RS10005	COG0420	3'-5' exonuclease activity
I7831_RS10010	COG4846	Membrane protein involved in cytochrome C biogenesis
I7831_RS10025	COG3763	UPF0154 protein
I7831_RS10035	COG4224	UPF0291 protein
I7831_RS10045	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I7831_RS10055	COG0516	GMP reductase activity
I7831_RS10060	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I7831_RS10065	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I7831_RS10070	COG0753	catalase activity
I7831_RS10075	COG0833	amino acid
I7831_RS10085	COG0561	phosphatase activity
I7831_RS10090	COG0083	homoserine kinase activity
I7831_RS10095	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I7831_RS10100	COG0460	homoserine dehydrogenase
I7831_RS10105	COG0527	aspartate kinase activity
I7831_RS10135	COG2197	response regulator
I7831_RS10150	COG0842	Transport permease protein
I7831_RS10155	COG1131	(ABC) transporter
I7831_RS10170	COG0789	Transcriptional regulator
I7831_RS10175	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I7831_RS10180	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I7831_RS10185	COG0386	Belongs to the glutathione peroxidase family
I7831_RS10190	COG1923	regulation of RNA biosynthetic process
I7831_RS10195	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I7831_RS10205	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I7831_RS10210	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I7831_RS10215	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I7831_RS10230	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I7831_RS10235	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I7831_RS10245	COG4550	Control of competence regulator ComK, YlbF/YmcA
I7831_RS10250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I7831_RS10275	COG1013	pyruvate-flavodoxin oxidoreductase activity
I7831_RS10280	COG0674	pyruvate-flavodoxin oxidoreductase activity
I7831_RS10280	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I7831_RS10285	COG1692	metallophosphoesterase
I7831_RS10295	COG1418	mRNA catabolic process
I7831_RS10300	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I7831_RS10305	COG1546	Belongs to the CinA family
I7831_RS10305	COG1058	Belongs to the CinA family
I7831_RS10325	COG0300	oxidoreductase activity
I7831_RS10330	COG0612	Peptidase, M16
I7831_RS10335	COG0612	Peptidase, M16
I7831_RS10340	COG2188	Transcriptional regulator
I7831_RS10345	COG1674	ftsk spoiiie
I7831_RS10350	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I7831_RS10355	COG1185	polyribonucleotide nucleotidyltransferase activity
I7831_RS10360	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I7831_RS10365	COG0196	riboflavin kinase activity
I7831_RS10370	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I7831_RS10375	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I7831_RS10390	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I7831_RS10395	COG1358	cellular component organization or biogenesis
I7831_RS10400	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I7831_RS10405	COG0195	Participates in both transcription termination and antitermination
I7831_RS10410	COG0779	Required for maturation of 30S ribosomal subunits
I7831_RS10415	COG2176	DNA-directed DNA polymerase activity
I7831_RS10420	COG0442	prolyl-tRNA aminoacylation
I7831_RS10430	COG4589	Belongs to the CDS family
I7831_RS10435	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I7831_RS10440	COG0233	cytoplasmic translational termination
I7831_RS10445	COG0528	UMP kinase activity
I7831_RS10450	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I7831_RS10455	COG0052	Belongs to the universal ribosomal protein uS2 family
I7831_RS10460	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I7831_RS10465	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I7831_RS10470	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I7831_RS10475	COG4974	Belongs to the 'phage' integrase family
I7831_RS10480	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I7831_RS10485	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I7831_RS10490	COG0758	DNA mediated transformation
I7831_RS10500	COG0045	succinate-CoA ligase (ADP-forming) activity
I7831_RS10505	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I7831_RS10515	COG4485	Bacterial membrane protein, YfhO
I7831_RS10525	COG0335	large ribosomal subunit rRNA binding
I7831_RS10530	COG0336	Belongs to the RNA methyltransferase TrmD family
I7831_RS10535	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I7831_RS10540	COG0228	four-way junction DNA binding
I7831_RS10545	COG1028	Short-chain dehydrogenase reductase Sdr
I7831_RS10550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I7831_RS10555	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I7831_RS10560	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I7831_RS10565	COG0552	protein localization to endoplasmic reticulum
I7831_RS10570	COG1196	nuclear chromosome segregation
I7831_RS10575	COG0571	ribonuclease III activity
I7831_RS10580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I7831_RS10595	COG0416	fatty acid biosynthetic process
I7831_RS10600	COG1349	DNA-binding transcription factor activity
I7831_RS10610	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I7831_RS10615	COG1760	l-serine dehydratase
I7831_RS10620	COG1760	l-serine dehydratase
I7831_RS10625	COG1461	Dihydroxyacetone kinase
I7831_RS10630	COG1302	Protein conserved in bacteria
I7831_RS10635	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I7831_RS10640	COG1564	THIamine pyrophosphokinase
I7831_RS10645	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I7831_RS10650	COG1162	GTPase activity
I7831_RS10660	COG0631	protein serine/threonine phosphatase activity
I7831_RS10665	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I7831_RS10670	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I7831_RS10670	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I7831_RS10675	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I7831_RS10680	COG0242	peptide deformylase activity
I7831_RS10695	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I7831_RS10700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I7831_RS10705	COG1758	RNA polymerase activity
I7831_RS10710	COG0194	GDP metabolic process
I7831_RS10715	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I7831_RS10725	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I7831_RS10735	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I7831_RS10740	COG0284	orotidine-5'-phosphate decarboxylase activity
I7831_RS10745	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I7831_RS10750	COG0505	Belongs to the CarA family
I7831_RS10760	COG0540	Belongs to the ATCase OTCase family
I7831_RS10770	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I7831_RS10775	COG0564	pseudouridine synthase activity
I7831_RS10780	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I7831_RS10790	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I7831_RS10795	COG3599	regulation of cell shape
I7831_RS10805	COG0762	integral membrane protein
I7831_RS10810	COG1799	cell septum assembly
I7831_RS10815	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I7831_RS10820	COG1496	oxidoreductase activity
I7831_RS10825	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I7831_RS10830	COG0849	cell division
I7831_RS10835	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I7831_RS10840	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I7831_RS10845	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I7831_RS10850	COG0768	penicillin binding
I7831_RS10855	COG4839	cell division protein FtsL
I7831_RS10860	COG0275	rRNA processing
I7831_RS10865	COG2001	Belongs to the MraZ family
I7831_RS10870	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
I7831_RS10875	COG0454	-acetyltransferase
I7831_RS10880	COG1011	Hydrolase
I7831_RS10915	COG2801	Transposase and inactivated derivatives
I7831_RS10965	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I7831_RS10970	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I7831_RS10975	COG1053	succinate dehydrogenase
I7831_RS10980	COG2009	succinate dehydrogenase
I7831_RS10985	COG0322	excinuclease ABC activity
I7831_RS10990	COG3118	belongs to the thioredoxin family
I7831_RS10995	COG1193	negative regulation of DNA recombination
I7831_RS11000	COG1796	DNA polymerase
I7831_RS11000	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I7831_RS11010	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
I7831_RS11015	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I7831_RS11020	COG0072	phenylalanine-tRNA ligase activity
I7831_RS11025	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I7831_RS11030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I7831_RS11040	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I7831_RS11050	COG1323	Belongs to the UPF0348 family
I7831_RS11055	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I7831_RS11060	COG0742	ribosomal rna small subunit methyltransferase
I7831_RS11075	COG0584	glycerophosphoryl diester phosphodiesterase
I7831_RS11080	COG3679	Belongs to the UPF0342 family
I7831_RS11090	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I7831_RS11100	COG0109	protoheme IX farnesyltransferase activity
I7831_RS11105	COG1612	heme a metabolic process
I7831_RS11115	COG0772	Belongs to the SEDS family
I7831_RS11120	COG4838	Belongs to the UPF0358 family
I7831_RS11125	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I7831_RS11130	COG4896	Protein conserved in bacteria
I7831_RS11135	COG1217	gtp-binding protein TYPA
I7831_RS11145	COG0483	inositol monophosphate 1-phosphatase activity
I7831_RS11150	COG4493	Belongs to the UPF0637 family
I7831_RS11160	COG1914	H( )-stimulated, divalent metal cation uptake system
I7831_RS11175	COG1177	transmembrane transport
I7831_RS11180	COG1176	ABC-type spermidine putrescine transport system, permease component I
I7831_RS11185	COG3842	ATPase activity
I7831_RS11195	COG4476	Belongs to the UPF0223 family
I7831_RS11235	COG5503	Protein of unknown function (DUF1447)
I7831_RS11240	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I7831_RS11250	COG0569	domain protein
I7831_RS11255	COG1294	oxidase, subunit
I7831_RS11260	COG1271	oxidase subunit
I7831_RS11275	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I7831_RS11285	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I7831_RS11305	COG4172	Belongs to the ABC transporter superfamily
I7831_RS11310	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I7831_RS11315	COG0151	Belongs to the GarS family
I7831_RS11320	COG0138	bifunctional purine biosynthesis protein purh
I7831_RS11330	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I7831_RS11340	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I7831_RS11345	COG0047	phosphoribosylformylglycinamidine synthase activity
I7831_RS11355	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I7831_RS11360	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I7831_RS11365	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I7831_RS11370	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I7831_RS11375	COG1017	nitric oxide dioxygenase activity
I7831_RS11375	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I7831_RS11385	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I7831_RS11390	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I7831_RS11395	COG1845	cytochrome c oxidase, subunit III
I7831_RS11400	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I7831_RS11410	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I7831_RS11415	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I7831_RS11420	COG1316	TRANSCRIPTIONal
I7831_RS11445	COG3594	Acyltransferase
I7831_RS11450	COG0436	Aminotransferase
I7831_RS11460	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I7831_RS11470	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I7831_RS11475	COG1169	isochorismate synthase
I7831_RS11480	COG1575	Belongs to the MenA family. Type 1 subfamily
I7831_RS11490	COG2314	TM2 domain
I7831_RS11495	COG1764	response to oxidative stress
I7831_RS11510	COG4903	ComK protein
I7831_RS11525	COG4873	Protein conserved in bacteria
I7831_RS11535	COG0737	Belongs to the 5'-nucleotidase family
I7831_RS11540	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I7831_RS11545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I7831_RS11550	COG0861	Integral membrane protein TerC family
I7831_RS11555	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I7831_RS11565	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I7831_RS11570	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I7831_RS11575	COG2814	Major facilitator Superfamily
I7831_RS11580	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I7831_RS11585	COG2382	esterase
I7831_RS11590	COG1115	amino acid carrier protein
I7831_RS11595	COG0628	permease
I7831_RS11605	COG0475	glutathione-regulated potassium exporter activity
I7831_RS11605	COG0569	domain protein
I7831_RS11610	COG2239	Acts as a magnesium transporter
I7831_RS11615	COG0564	pseudouridine synthase activity
I7831_RS11620	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I7831_RS11625	COG2357	RelA SpoT domain protein
I7831_RS11635	COG4116	CYTH
I7831_RS11640	COG2346	COG2346, Truncated hemoglobins
I7831_RS11645	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I7831_RS11650	COG2910	NAD(P)H-binding
I7831_RS11655	COG1164	Oligoendopeptidase f
I7831_RS11665	COG4862	establishment of competence for transformation
I7831_RS11670	COG1393	Belongs to the ArsC family
I7831_RS11675	COG0180	Tryptophanyl-tRNA synthetase
I7831_RS11680	COG4166	transmembrane transport
I7831_RS11685	COG4608	Belongs to the ABC transporter superfamily
I7831_RS11690	COG0444	Belongs to the ABC transporter superfamily
I7831_RS11695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I7831_RS11700	COG0601	transmembrane transport
I7831_RS11720	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I7831_RS11730	COG0542	response to heat
I7831_RS11745	COG0561	phosphatase activity
I7831_RS11750	COG0446	pyridine nucleotide-disulphide oxidoreductase
I7831_RS11760	COG0179	Fumarylacetoacetate (FAA) hydrolase
I7831_RS11765	COG2311	Membrane
I7831_RS11770	COG1074	ATP-dependent DNA helicase activity
I7831_RS11775	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I7831_RS11790	COG0398	Pfam SNARE associated Golgi protein
I7831_RS11795	COG0166	Belongs to the GPI family
I7831_RS11800	COG0137	argininosuccinate synthase activity
I7831_RS11805	COG0165	Argininosuccinate lyase
I7831_RS11810	COG0584	glycerophosphoryl diester phosphodiesterase
I7831_RS11820	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I7831_RS11825	COG1902	pentaerythritol trinitrate reductase activity
I7831_RS11830	COG1098	S1 RNA binding domain
I7831_RS11835	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I7831_RS11845	COG2111	Na H antiporter
I7831_RS11845	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I7831_RS11850	COG2111	Na H antiporter
I7831_RS11855	COG1006	Multisubunit Na H antiporter MnhC subunit
I7831_RS11860	COG0651	ATP synthesis coupled electron transport
I7831_RS11865	COG1863	multisubunit Na H antiporter MnhE subunit
I7831_RS11870	COG2212	antiporter activity
I7831_RS11875	COG1320	monovalent cation:proton antiporter activity
I7831_RS11885	COG2050	protein possibly involved in aromatic compounds catabolism
I7831_RS11890	COG2056	Na+-H+ antiporter family
I7831_RS11895	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I7831_RS11900	COG1252	NADH dehydrogenase
I7831_RS11905	COG0316	Belongs to the HesB IscA family
I7831_RS11910	COG4844	belongs to the
I7831_RS11915	COG1252	NADH dehydrogenase
I7831_RS11920	COG4837	Protein of unknown function (DUF1462)
I7831_RS11925	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I7831_RS11930	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I7831_RS11935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I7831_RS11940	COG1696	Membrane protein involved in D-alanine export
I7831_RS11945	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I7831_RS11960	COG0647	UMP catabolic process
I7831_RS11965	COG2445	Protein of unknown function DUF86
I7831_RS11975	COG4470	Protein conserved in bacteria
I7831_RS11980	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I7831_RS11985	COG0737	Belongs to the 5'-nucleotidase family
I7831_RS11990	COG0730	response to heat
I7831_RS11995	COG1801	Protein of unknown function DUF72
I7831_RS12000	COG2070	2-Nitropropane dioxygenase
I7831_RS12005	COG1253	flavin adenine dinucleotide binding
I7831_RS12015	COG0719	Fe-S assembly protein
I7831_RS12020	COG0822	iron-sulfur transferase activity
I7831_RS12025	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I7831_RS12030	COG0719	Fe-S assembly protein
I7831_RS12035	COG0396	ATPase activity
I7831_RS12045	COG1253	flavin adenine dinucleotide binding
I7831_RS12055	COG1464	Belongs to the NlpA lipoprotein family
I7831_RS12060	COG2011	ABC-type metal ion transport system permease component
I7831_RS12065	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I7831_RS12070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I7831_RS12075	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I7831_RS12080	COG0509	glycine decarboxylation via glycine cleavage system
I7831_RS12085	COG1393	Belongs to the ArsC family
I7831_RS12090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I7831_RS12095	COG0778	Nitroreductase
I7831_RS12100	COG0710	3-dehydroquinate dehydratase activity
I7831_RS12105	COG1764	response to oxidative stress
I7831_RS12120	COG2851	Citrate transporter
I7831_RS12135	COG2314	TM2 domain
I7831_RS12180	COG0346	lactoylglutathione lyase activity
I7831_RS12210	COG3655	Transcriptional regulator
I7831_RS12270	COG0346	lactoylglutathione lyase activity
I7831_RS12275	COG0546	phosphoglycolate phosphatase activity
I7831_RS12280	COG2259	Doxx family
I7831_RS12285	COG2153	protein acetylation
I7831_RS12340	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I7831_RS12345	COG0557	exoribonuclease II activity
I7831_RS12350	COG1647	Serine aminopeptidase, S33
I7831_RS12355	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I7831_RS12365	COG0148	phosphopyruvate hydratase activity
I7831_RS12370	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I7831_RS12375	COG0149	triose-phosphate isomerase activity
I7831_RS12380	COG0126	phosphoglycerate kinase activity
I7831_RS12405	COG1090	epimerase
I7831_RS12415	COG0740	serine-type endopeptidase activity
I7831_RS12430	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I7831_RS12435	COG1481	regulation of sporulation
I7831_RS12440	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I7831_RS12445	COG1660	Displays ATPase and GTPase activities
I7831_RS12450	COG0492	ferredoxin-NADP+ reductase activity
I7831_RS12460	COG0110	maltose O-acetyltransferase activity
I7831_RS12465	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I7831_RS12470	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I7831_RS12480	COG0556	nucleotide-excision repair
I7831_RS12495	COG1388	LysM domain
I7831_RS12495	COG3942	CHAP domain
I7831_RS12505	COG0653	protein targeting
I7831_RS12510	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I7831_RS12515	COG1040	competence protein
I7831_RS12520	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I7831_RS12530	COG1739	Uncharacterized protein family UPF0029
I7831_RS12535	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I7831_RS12540	COG2199	diguanylate cyclase activity
I7831_RS12555	COG2195	Cleaves the N-terminal amino acid of tripeptides
I7831_RS12560	COG1929	Belongs to the glycerate kinase type-1 family
I7831_RS12580	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I7831_RS12595	COG4607	ABC-type enterochelin transport system periplasmic component
I7831_RS12600	COG4604	ABC transporter, ATP-binding protein
I7831_RS12605	COG4605	iron ion homeostasis
I7831_RS12610	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I7831_RS12615	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I7831_RS12620	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I7831_RS12625	COG1780	Probably involved in ribonucleotide reductase function
I7831_RS12635	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I7831_RS12640	COG3104	oligopeptide transport
I7831_RS12645	COG3104	oligopeptide transport
I7831_RS12650	COG1597	lipid kinase activity
I7831_RS12660	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I7831_RS12665	COG1174	glycine betaine transport
I7831_RS12670	COG1125	glycine betaine transport
I7831_RS12670	COG0517	IMP dehydrogenase activity
I7831_RS12675	COG0514	ATP-dependent DNA helicase (RecQ)
I7831_RS12680	COG0488	(ABC) transporter
I7831_RS12690	COG1368	sulfuric ester hydrolase activity
I7831_RS12700	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I7831_RS12715	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I7831_RS12715	COG0512	Glutamine amidotransferase of anthranilate synthase
I7831_RS12720	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I7831_RS12725	COG0720	synthase
I7831_RS12730	COG0602	queuosine metabolic process
I7831_RS12745	COG0463	Glycosyl transferase, family 2
I7831_RS12750	COG0656	L-ascorbic acid biosynthetic process
I7831_RS12755	COG1253	flavin adenine dinucleotide binding
I7831_RS12760	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I7831_RS12765	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I7831_RS12765	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I7831_RS12765	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I7831_RS12770	COG1105	Belongs to the carbohydrate kinase PfkB family
I7831_RS12775	COG1349	DNA-binding transcription factor activity
I7831_RS12780	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I7831_RS12785	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I7831_RS12810	COG0039	L-malate dehydrogenase activity
I7831_RS12815	COG0586	Pfam SNARE associated Golgi protein
I7831_RS12825	COG4989	oxidoreductase activity
I7831_RS12840	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I7831_RS12845	COG4988	ABC transporter
I7831_RS12850	COG1968	undecaprenyl-diphosphatase activity
I7831_RS12860	COG1671	Belongs to the UPF0178 family
I7831_RS12865	COG1611	Belongs to the LOG family
I7831_RS12870	COG1279	arginine transmembrane transporter activity
I7831_RS12905	COG2814	Major facilitator Superfamily
I7831_RS12910	COG2839	Protein conserved in bacteria
I7831_RS12915	COG2814	Major facilitator Superfamily
I7831_RS12920	COG0583	DNA-binding transcription factor activity
I7831_RS12930	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I7831_RS12940	COG0217	transcriptional regulatory protein
I7831_RS12960	COG3942	CHAP domain
I7831_RS12960	COG1388	LysM domain
I7831_RS12965	COG0306	phosphate transporter
I7831_RS12970	COG1392	Phosphate transport regulator
I7831_RS12975	COG2205	protein histidine kinase activity
I7831_RS12980	COG0745	RESPONSE REGULATOR receiver
I7831_RS12985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I7831_RS12995	COG0657	acetylesterase activity
I7831_RS13000	COG3949	Membrane
I7831_RS13020	COG0456	acetyltransferase
I7831_RS13035	COG4086	secreted protein
I7831_RS13075	COG1192	Involved in chromosome partitioning
I7831_RS13085	COG3942	CHAP domain
I7831_RS13085	COG1388	LysM domain
I7831_RS13190	COG0477	Major facilitator Superfamily
I7831_RS13195	COG2249	NAD(P)H dehydrogenase (quinone) activity
I7831_RS13215	COG2003	Belongs to the UPF0758 family
I7831_RS13250	COG0488	(ABC) transporter
I7831_RS13275	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I7831_RS13285	COG2226	methyltransferase
I7831_RS13315	COG0730	response to heat
I7831_RS13320	COG1937	Protein conserved in bacteria
I7831_RS13325	COG2210	Belongs to the sulfur carrier protein TusA family
I7831_RS13330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I7831_RS13345	COG0477	Major facilitator Superfamily
I7831_RS13350	COG3173	Aminoglycoside phosphotransferase
I7831_RS13365	COG2205	protein histidine kinase activity
I7831_RS13380	COG0745	RESPONSE REGULATOR receiver