locus-tag	class	description
HSZ47_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HSZ47_RS00010	COG0592	DNA-directed DNA polymerase activity
HSZ47_RS00015	COG2501	S4 domain
HSZ47_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HSZ47_RS00025	COG0187	DNA topoisomerase II activity
HSZ47_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HSZ47_RS00040	COG2986	histidine ammonia-lyase
HSZ47_RS00045	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HSZ47_RS00050	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HSZ47_RS00060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HSZ47_RS00070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HSZ47_RS00075	COG0359	binds to the 23S rRNA
HSZ47_RS00080	COG0305	Participates in initiation and elongation during chromosome replication
HSZ47_RS00085	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HSZ47_RS00090	COG1819	glycosyl
HSZ47_RS00110	COG0477	Major facilitator Superfamily
HSZ47_RS00115	COG0745	RESPONSE REGULATOR receiver
HSZ47_RS00120	COG5002	protein histidine kinase activity
HSZ47_RS00125	COG4863	YycH protein
HSZ47_RS00135	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HSZ47_RS00140	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HSZ47_RS00220	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HSZ47_RS00240	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HSZ47_RS00240	COG0463	Glycosyl transferase, family 2
HSZ47_RS00270	COG0732	type I restriction modification DNA specificity domain
HSZ47_RS00280	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HSZ47_RS00295	COG1388	LysM domain
HSZ47_RS00300	COG0730	response to heat
HSZ47_RS00305	COG1937	Protein conserved in bacteria
HSZ47_RS00310	COG2210	Belongs to the sulfur carrier protein TusA family
HSZ47_RS00315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HSZ47_RS00325	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HSZ47_RS00330	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HSZ47_RS00355	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HSZ47_RS00360	COG1113	amino acid transport
HSZ47_RS00380	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HSZ47_RS00390	COG0789	Transcriptional regulator
HSZ47_RS00400	COG0702	epimerase
HSZ47_RS00405	COG2130	NADP-dependent
HSZ47_RS00420	COG0702	epimerase
HSZ47_RS00425	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HSZ47_RS00505	COG0789	Transcriptional regulator
HSZ47_RS00515	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HSZ47_RS00520	COG2022	thiamine diphosphate biosynthetic process
HSZ47_RS00530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HSZ47_RS00540	COG1070	Carbohydrate kinase
HSZ47_RS00550	COG2814	Major facilitator Superfamily
HSZ47_RS00575	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HSZ47_RS00585	COG0579	oxidoreductase
HSZ47_RS00590	COG0028	Belongs to the TPP enzyme family
HSZ47_RS00595	COG3527	Alpha-acetolactate decarboxylase
HSZ47_RS00600	COG1620	l-lactate permease
HSZ47_RS00605	COG0583	DNA-binding transcription factor activity
HSZ47_RS00625	COG1136	(ABC) transporter
HSZ47_RS00685	COG1733	regulation of RNA biosynthetic process
HSZ47_RS00690	COG2207	Transcriptional regulator
HSZ47_RS00695	COG2211	Major facilitator Superfamily
HSZ47_RS00700	COG3250	beta-galactosidase activity
HSZ47_RS00715	COG3949	Membrane
HSZ47_RS00725	COG1131	(ABC) transporter
HSZ47_RS00735	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
HSZ47_RS00750	COG0463	Glycosyl transferase, family 2
HSZ47_RS00790	COG1028	Short-chain dehydrogenase reductase Sdr
HSZ47_RS00805	COG1388	LysM domain
HSZ47_RS00810	COG1388	LysM domain
HSZ47_RS00815	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HSZ47_RS00830	COG1263	PTS System
HSZ47_RS00830	COG2190	(PTS) system
HSZ47_RS00830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HSZ47_RS00875	COG1131	(ABC) transporter
HSZ47_RS00900	COG1511	domain protein
HSZ47_RS00900	COG1511	domain protein
HSZ47_RS00925	COG1328	CTP reductase activity
HSZ47_RS00940	COG0346	lactoylglutathione lyase activity
HSZ47_RS00965	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HSZ47_RS00970	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HSZ47_RS00975	COG0579	oxidoreductase
HSZ47_RS01010	COG0477	Major facilitator Superfamily
HSZ47_RS01020	COG2814	Major facilitator Superfamily
HSZ47_RS01025	COG0583	DNA-binding transcription factor activity
HSZ47_RS01040	COG0584	glycerophosphoryl diester phosphodiesterase
HSZ47_RS01050	COG3961	Belongs to the TPP enzyme family
HSZ47_RS01060	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HSZ47_RS01065	COG1691	(AIR) carboxylase
HSZ47_RS01070	COG1606	tRNA processing
HSZ47_RS01075	COG3875	lactate racemase activity
HSZ47_RS01085	COG3835	regulator
HSZ47_RS01090	COG0574	Belongs to the PEP-utilizing enzyme family
HSZ47_RS01090	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HSZ47_RS01095	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HSZ47_RS01105	COG1396	sequence-specific DNA binding
HSZ47_RS01110	COG2807	transmembrane transport
HSZ47_RS01120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HSZ47_RS01125	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HSZ47_RS01130	COG1012	belongs to the aldehyde dehydrogenase family
HSZ47_RS01135	COG0531	amino acid
HSZ47_RS01150	COG2264	protein methyltransferase activity
HSZ47_RS01160	COG1510	regulation of RNA biosynthetic process
HSZ47_RS01165	COG1012	belongs to the aldehyde dehydrogenase family
HSZ47_RS01170	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HSZ47_RS01175	COG0583	DNA-binding transcription factor activity
HSZ47_RS01185	COG4221	oxidoreductase activity
HSZ47_RS01200	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HSZ47_RS01200	COG0463	Glycosyl transferase, family 2
HSZ47_RS01215	COG0778	Nitroreductase
HSZ47_RS01220	COG2843	Capsule synthesis protein
HSZ47_RS01225	COG1957	nucleoside hydrolase
HSZ47_RS01230	COG0477	Major facilitator Superfamily
HSZ47_RS01250	COG1131	(ABC) transporter
HSZ47_RS01260	COG0531	amino acid
HSZ47_RS01265	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HSZ47_RS01270	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HSZ47_RS01275	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HSZ47_RS01280	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HSZ47_RS01295	COG0431	NADPH-dependent FMN reductase
HSZ47_RS01300	COG3226	Transcriptional regulator
HSZ47_RS01315	COG1620	l-lactate permease
HSZ47_RS01320	COG2814	Major facilitator Superfamily
HSZ47_RS01335	COG0363	glucosamine-6-phosphate deaminase activity
HSZ47_RS01350	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HSZ47_RS01365	COG1447	Phosphotransferase system cellobiose-specific component IIA
HSZ47_RS01370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HSZ47_RS01375	COG0765	amino acid transport
HSZ47_RS01380	COG1126	abc transporter atp-binding protein
HSZ47_RS01395	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HSZ47_RS01405	COG1464	Belongs to the NlpA lipoprotein family
HSZ47_RS01410	COG0039	L-malate dehydrogenase activity
HSZ47_RS01415	COG1940	carbohydrate kinase activity
HSZ47_RS01425	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HSZ47_RS01430	COG0626	cystathionine gamma-synthase activity
HSZ47_RS01455	COG0829	nickel cation binding
HSZ47_RS01460	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HSZ47_RS01465	COG0830	nickel cation binding
HSZ47_RS01470	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HSZ47_RS01475	COG0804	urea catabolic process
HSZ47_RS01480	COG0832	Belongs to the urease beta subunit family
HSZ47_RS01485	COG0831	urea catabolic process
HSZ47_RS01490	COG4413	Urea transporter
HSZ47_RS01495	COG0747	negative chemotaxis
HSZ47_RS01520	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HSZ47_RS01530	COG0531	amino acid
HSZ47_RS01540	COG0561	phosphatase activity
HSZ47_RS01550	COG0167	dihydroorotate dehydrogenase activity
HSZ47_RS01555	COG3001	Fructosamine kinase
HSZ47_RS01580	COG0697	spore germination
HSZ47_RS01585	COG1113	amino acid transport
HSZ47_RS01605	COG3189	MarR family transcriptional regulator
HSZ47_RS01620	COG1388	LysM domain
HSZ47_RS01625	COG0436	Aminotransferase
HSZ47_RS01635	COG2608	mercury ion transmembrane transporter activity
HSZ47_RS01640	COG2217	Heavy metal translocating P-type atpase
HSZ47_RS01645	COG0659	secondary active sulfate transmembrane transporter activity
HSZ47_RS01650	COG1136	(ABC) transporter
HSZ47_RS01655	COG0577	efflux transmembrane transporter activity
HSZ47_RS01660	COG1028	Short-chain dehydrogenase reductase Sdr
HSZ47_RS01675	COG0471	metal ion transport
HSZ47_RS01680	COG5505	Protein of unknown function (DUF819)
HSZ47_RS01695	COG4336	lyase activity
HSZ47_RS01705	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HSZ47_RS01710	COG1012	belongs to the aldehyde dehydrogenase family
HSZ47_RS01720	COG2409	Drug exporters of the RND superfamily
HSZ47_RS01735	COG1473	amidohydrolase
HSZ47_RS01760	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HSZ47_RS01765	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HSZ47_RS01770	COG3425	synthase
HSZ47_RS01785	COG3386	PFAM SMP-30 Gluconolaconase
HSZ47_RS01790	COG3942	CHAP domain
HSZ47_RS01800	COG0583	DNA-binding transcription factor activity
HSZ47_RS01810	COG1346	cytolysis
HSZ47_RS01815	COG0028	Belongs to the TPP enzyme family
HSZ47_RS01820	COG1288	antiporter activity
HSZ47_RS01825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HSZ47_RS01825	COG1263	PTS System
HSZ47_RS01825	COG2190	(PTS) system
HSZ47_RS01835	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HSZ47_RS01845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HSZ47_RS01870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HSZ47_RS01880	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HSZ47_RS01890	COG2843	Capsule synthesis protein
HSZ47_RS01910	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HSZ47_RS01915	COG1063	alcohol dehydrogenase
HSZ47_RS01920	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HSZ47_RS01940	COG1129	ABC transporter
HSZ47_RS01960	COG1070	Carbohydrate kinase
HSZ47_RS01965	COG1063	alcohol dehydrogenase
HSZ47_RS01980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HSZ47_RS01990	COG3764	Sortase (surface protein transpeptidase)
HSZ47_RS01995	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HSZ47_RS02000	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HSZ47_RS02005	COG1940	carbohydrate kinase activity
HSZ47_RS02010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HSZ47_RS02025	COG2249	NAD(P)H dehydrogenase (quinone) activity
HSZ47_RS02030	COG0561	phosphatase activity
HSZ47_RS02035	COG0778	Nitroreductase
HSZ47_RS02040	COG2723	6-phospho-beta-galactosidase activity
HSZ47_RS02045	COG3711	transcriptional antiterminator
HSZ47_RS02055	COG3711	transcriptional antiterminator
HSZ47_RS02060	COG2514	catechol 2,3-dioxygenase activity
HSZ47_RS02070	COG1132	(ABC) transporter
HSZ47_RS02075	COG1132	(ABC) transporter
HSZ47_RS02095	COG1846	Transcriptional regulator
HSZ47_RS02100	COG0346	lactoylglutathione lyase activity
HSZ47_RS02105	COG0346	lactoylglutathione lyase activity
HSZ47_RS02110	COG0400	carboxylic ester hydrolase activity
HSZ47_RS02120	COG0471	metal ion transport
HSZ47_RS02125	COG3949	Membrane
HSZ47_RS02135	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HSZ47_RS02140	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HSZ47_RS02145	COG0586	Pfam SNARE associated Golgi protein
HSZ47_RS02150	COG2271	Major facilitator Superfamily
HSZ47_RS02160	COG1289	transmembrane transporter activity
HSZ47_RS02175	COG4876	unkown
HSZ47_RS02180	COG2357	RelA SpoT domain protein
HSZ47_RS02190	COG1802	Transcriptional regulator
HSZ47_RS02200	COG2610	gluconate transmembrane transporter activity
HSZ47_RS02210	COG3949	Membrane
HSZ47_RS02230	COG4221	oxidoreductase activity
HSZ47_RS02255	COG0107	imidazoleglycerol-phosphate synthase activity
HSZ47_RS02260	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HSZ47_RS02265	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HSZ47_RS02270	COG0131	Imidazoleglycerol-phosphate dehydratase
HSZ47_RS02275	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HSZ47_RS02280	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HSZ47_RS02285	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HSZ47_RS02290	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HSZ47_RS02295	COG3048	D-serine ammonia-lyase activity
HSZ47_RS02300	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HSZ47_RS02305	COG0248	Ppx GppA phosphatase
HSZ47_RS02310	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HSZ47_RS02315	COG1028	Short-chain dehydrogenase reductase Sdr
HSZ47_RS02320	COG1363	Peptidase, m42
HSZ47_RS02330	COG0069	glutamate synthase activity
HSZ47_RS02340	COG4619	ABC transporter
HSZ47_RS02345	COG0390	transport system, permease component
HSZ47_RS02350	COG2814	Major facilitator Superfamily
HSZ47_RS02355	COG0531	amino acid
HSZ47_RS02360	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HSZ47_RS02370	COG3246	L-lysine catabolic process to acetate
HSZ47_RS02375	COG1250	3-hydroxyacyl-CoA dehydrogenase
HSZ47_RS02390	COG1174	glycine betaine transport
HSZ47_RS02400	COG1174	glycine betaine transport
HSZ47_RS02410	COG1960	acyl-CoA dehydrogenase activity
HSZ47_RS02415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HSZ47_RS02425	COG1116	anion transmembrane transporter activity
HSZ47_RS02435	COG1346	cytolysis
HSZ47_RS02440	COG1380	Effector of murein hydrolase LrgA
HSZ47_RS02445	COG3279	Response regulator of the LytR AlgR family
HSZ47_RS02450	COG3275	phosphorelay sensor kinase activity
HSZ47_RS02460	COG4187	Peptidase family M20/M25/M40
HSZ47_RS02480	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HSZ47_RS02495	COG0025	NhaP-type Na H and K H
HSZ47_RS02515	COG2814	Major facilitator Superfamily
HSZ47_RS02525	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HSZ47_RS02530	COG1388	LysM domain
HSZ47_RS02535	COG0588	phosphoglycerate mutase activity
HSZ47_RS02545	COG2814	Major facilitator Superfamily
HSZ47_RS02575	COG3443	Belongs to the bacterial solute-binding protein 9 family
HSZ47_RS02575	COG0803	Belongs to the bacterial solute-binding protein 9 family
HSZ47_RS02580	COG2353	YceI-like domain
HSZ47_RS02615	COG1959	2 iron, 2 sulfur cluster binding
HSZ47_RS02620	COG2116	formate transmembrane transporter activity
HSZ47_RS02625	COG0454	-acetyltransferase
HSZ47_RS02640	COG0071	Belongs to the small heat shock protein (HSP20) family
HSZ47_RS02650	COG1846	Transcriptional regulator
HSZ47_RS02670	COG2207	Transcriptional regulator
HSZ47_RS02680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HSZ47_RS02680	COG1263	PTS System
HSZ47_RS02700	COG1283	sodium-dependent phosphate transmembrane transporter activity
HSZ47_RS02705	COG1028	Short-chain dehydrogenase reductase Sdr
HSZ47_RS02710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HSZ47_RS02715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HSZ47_RS02720	COG1288	antiporter activity
HSZ47_RS02725	COG1349	DNA-binding transcription factor activity
HSZ47_RS02730	COG1063	alcohol dehydrogenase
HSZ47_RS02735	COG2376	Dihydroxyacetone kinase
HSZ47_RS02745	COG0698	ribose 5-phosphate isomerase
HSZ47_RS02755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HSZ47_RS02760	COG0492	ferredoxin-NADP+ reductase activity
HSZ47_RS02770	COG2814	Major facilitator Superfamily
HSZ47_RS02775	COG0604	alcohol dehydrogenase
HSZ47_RS02790	COG0463	Glycosyl transferase, family 2
HSZ47_RS02790	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HSZ47_RS02795	COG1620	l-lactate permease
HSZ47_RS02800	COG0438	transferase activity, transferring glycosyl groups
HSZ47_RS02810	COG5002	protein histidine kinase activity
HSZ47_RS02810	COG3850	Histidine kinase
HSZ47_RS02815	COG0745	RESPONSE REGULATOR receiver
HSZ47_RS02820	COG0577	efflux transmembrane transporter activity
HSZ47_RS02825	COG1136	(ABC) transporter
HSZ47_RS02840	COG4640	response to antibiotic
HSZ47_RS02845	COG2814	Major facilitator Superfamily
HSZ47_RS02855	COG1566	PFAM secretion protein HlyD family protein
HSZ47_RS02860	COG2814	Major facilitator Superfamily
HSZ47_RS02885	COG0598	Magnesium transport protein CorA
HSZ47_RS02890	COG1304	FMN binding
HSZ47_RS02895	COG0786	glutamate:sodium symporter activity
HSZ47_RS02910	COG1757	Na H antiporter
HSZ47_RS02915	COG2094	Belongs to the DNA glycosylase MPG family
HSZ47_RS02920	COG3152	Membrane
HSZ47_RS02925	COG1069	ribulokinase activity
HSZ47_RS02930	COG4152	abc transporter atp-binding protein
HSZ47_RS02935	COG1668	transmembrane transport
HSZ47_RS02940	COG2017	converts alpha-aldose to the beta-anomer
HSZ47_RS02945	COG2258	MOSC domain
HSZ47_RS02950	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HSZ47_RS02955	COG1266	CAAX protease self-immunity
HSZ47_RS02960	COG0010	Belongs to the arginase family
HSZ47_RS02965	COG0583	DNA-binding transcription factor activity
HSZ47_RS02970	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HSZ47_RS02975	COG1228	amidohydrolase
HSZ47_RS02980	COG0659	secondary active sulfate transmembrane transporter activity
HSZ47_RS02985	COG1473	amidohydrolase
HSZ47_RS02990	COG1028	Short-chain dehydrogenase reductase Sdr
HSZ47_RS02995	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HSZ47_RS03015	COG2801	Transposase and inactivated derivatives
HSZ47_RS03025	COG1263	PTS System
HSZ47_RS03025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HSZ47_RS03035	COG0385	Bile acid
HSZ47_RS03040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HSZ47_RS03065	COG1113	amino acid transport
HSZ47_RS03070	COG1785	Belongs to the alkaline phosphatase family
HSZ47_RS03075	COG1737	Transcriptional regulator
HSZ47_RS03080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HSZ47_RS03080	COG1263	PTS System
HSZ47_RS03085	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HSZ47_RS03105	COG0483	inositol monophosphate 1-phosphatase activity
HSZ47_RS03110	COG1316	TRANSCRIPTIONal
HSZ47_RS03115	COG3383	formate dehydrogenase (NAD+) activity
HSZ47_RS03130	COG4193	domain, Protein
HSZ47_RS03140	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HSZ47_RS03145	COG2076	Multidrug Resistance protein
HSZ47_RS03150	COG2076	Multidrug Resistance protein
HSZ47_RS03155	COG3942	CHAP domain
HSZ47_RS03170	COG1757	Na H antiporter
HSZ47_RS03175	COG3942	CHAP domain
HSZ47_RS03205	COG0765	amino acid transport
HSZ47_RS03215	COG1126	abc transporter atp-binding protein
HSZ47_RS03220	COG1960	acyl-CoA dehydrogenase activity
HSZ47_RS03225	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HSZ47_RS03230	COG1268	BioY protein
HSZ47_RS03240	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HSZ47_RS03245	COG1609	Transcriptional regulator
HSZ47_RS03250	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HSZ47_RS03255	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HSZ47_RS03260	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HSZ47_RS03265	COG0725	ABC transporter, periplasmic molybdate-binding protein
HSZ47_RS03270	COG4149	molybdate abc transporter
HSZ47_RS03285	COG1510	regulation of RNA biosynthetic process
HSZ47_RS03290	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HSZ47_RS03295	COG0521	Mo-molybdopterin cofactor biosynthetic process
HSZ47_RS03300	COG0315	cyclic pyranopterin monophosphate synthase activity
HSZ47_RS03310	COG1763	Mo-molybdopterin cofactor biosynthetic process
HSZ47_RS03325	COG0746	molybdenum cofactor guanylyltransferase activity
HSZ47_RS03330	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HSZ47_RS03360	COG2348	transferase activity, transferring amino-acyl groups
HSZ47_RS03365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HSZ47_RS03390	COG4975	Glucose uptake
HSZ47_RS03400	COG0551	DNA topoisomerase type I activity
HSZ47_RS03400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HSZ47_RS03405	COG2252	PERMEase
HSZ47_RS03415	COG0051	transcription antitermination factor activity, RNA binding
HSZ47_RS03420	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HSZ47_RS03425	COG0088	Forms part of the polypeptide exit tunnel
HSZ47_RS03430	COG0089	rRNA binding
HSZ47_RS03435	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HSZ47_RS03440	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HSZ47_RS03445	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HSZ47_RS03450	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HSZ47_RS03455	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HSZ47_RS03460	COG0255	Belongs to the universal ribosomal protein uL29 family
HSZ47_RS03465	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HSZ47_RS03470	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HSZ47_RS03475	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HSZ47_RS03480	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HSZ47_RS03485	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HSZ47_RS03490	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HSZ47_RS03495	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HSZ47_RS03500	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HSZ47_RS03505	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HSZ47_RS03510	COG1841	ribosomal large subunit assembly
HSZ47_RS03515	COG0200	Binds to the 23S rRNA
HSZ47_RS03520	COG0201	protein transport
HSZ47_RS03525	COG0563	adenylate kinase activity
HSZ47_RS03535	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HSZ47_RS03540	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HSZ47_RS03545	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HSZ47_RS03550	COG0202	RNA polymerase activity
HSZ47_RS03555	COG0203	ribosomal protein L17
HSZ47_RS03560	COG1122	ATPase activity
HSZ47_RS03565	COG1122	ATPase activity
HSZ47_RS03575	COG0101	tRNA pseudouridine synthase activity
HSZ47_RS03580	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HSZ47_RS03585	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HSZ47_RS03595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HSZ47_RS03600	COG2130	NADP-dependent
HSZ47_RS03605	COG0604	alcohol dehydrogenase
HSZ47_RS03610	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HSZ47_RS03625	COG1302	Protein conserved in bacteria
HSZ47_RS03630	COG4264	IucA IucC family
HSZ47_RS03635	COG2814	Major facilitator Superfamily
HSZ47_RS03640	COG4264	IucA IucC family
HSZ47_RS03645	COG3457	Alanine racemase
HSZ47_RS03650	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HSZ47_RS03655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HSZ47_RS03660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HSZ47_RS03670	COG2329	Antibiotic biosynthesis monooxygenase
HSZ47_RS03680	COG1988	membrane-bound metal-dependent
HSZ47_RS03685	COG4284	Utp--glucose-1-phosphate uridylyltransferase
HSZ47_RS03690	COG1272	protein, Hemolysin III
HSZ47_RS03705	COG0489	protein tyrosine kinase activity
HSZ47_RS03760	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HSZ47_RS03770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HSZ47_RS03775	COG0246	Mannitol dehydrogenase
HSZ47_RS03785	COG3711	transcriptional antiterminator
HSZ47_RS03790	COG2213	PTS system mannitol-specific
HSZ47_RS03805	COG1119	ATPase activity
HSZ47_RS03830	COG0640	Transcriptional regulator
HSZ47_RS03835	COG0702	epimerase
HSZ47_RS03840	COG2186	Transcriptional regulator
HSZ47_RS03845	COG1482	cell wall glycoprotein biosynthetic process
HSZ47_RS03855	COG2855	membrane
HSZ47_RS03870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HSZ47_RS03875	COG0783	Belongs to the Dps family
HSZ47_RS03885	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HSZ47_RS03890	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HSZ47_RS03895	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HSZ47_RS03905	COG1854	S-ribosylhomocysteine lyase activity
HSZ47_RS03925	COG5146	pantothenate kinase activity
HSZ47_RS03930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HSZ47_RS03935	COG3343	RNA polymerase activity
HSZ47_RS03940	COG0504	CTP synthase activity
HSZ47_RS03945	COG0191	fructose-bisphosphate aldolase activity
HSZ47_RS03950	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HSZ47_RS03960	COG1012	belongs to the aldehyde dehydrogenase family
HSZ47_RS03965	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HSZ47_RS03970	COG0254	rRNA binding
HSZ47_RS03975	COG1435	thymidine kinase activity
HSZ47_RS03980	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HSZ47_RS03985	COG2890	protein-(glutamine-N5) methyltransferase activity
HSZ47_RS03990	COG0009	L-threonylcarbamoyladenylate synthase
HSZ47_RS03995	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HSZ47_RS04000	COG4475	Protein of unknown function (DUF436)
HSZ47_RS04005	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HSZ47_RS04010	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HSZ47_RS04015	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HSZ47_RS04025	COG0356	it plays a direct role in the translocation of protons across the membrane
HSZ47_RS04030	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HSZ47_RS04035	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HSZ47_RS04040	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HSZ47_RS04045	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HSZ47_RS04050	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HSZ47_RS04055	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HSZ47_RS04060	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HSZ47_RS04070	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HSZ47_RS04075	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HSZ47_RS04085	COG0629	single-stranded DNA binding
HSZ47_RS04090	COG1388	LysM domain
HSZ47_RS04095	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HSZ47_RS04105	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HSZ47_RS04110	COG0352	thiamine-phosphate diphosphorylase activity
HSZ47_RS04115	COG0706	membrane insertase activity
HSZ47_RS04120	COG1418	mRNA catabolic process
HSZ47_RS04130	COG1937	Protein conserved in bacteria
HSZ47_RS04145	COG0772	Belongs to the SEDS family
HSZ47_RS04150	COG1181	Belongs to the D-alanine--D-alanine ligase family
HSZ47_RS04155	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HSZ47_RS04160	COG0513	Belongs to the DEAD box helicase family
HSZ47_RS04170	COG3428	Bacterial PH domain
HSZ47_RS04175	COG3402	PFAM membrane-flanked domain
HSZ47_RS04180	COG0736	holo-[acyl-carrier-protein] synthase activity
HSZ47_RS04185	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HSZ47_RS04195	COG2337	Toxic component of a toxin-antitoxin (TA) module
HSZ47_RS04200	COG2208	phosphoserine phosphatase activity
HSZ47_RS04215	COG1191	sigma factor activity
HSZ47_RS04220	COG2183	response to ionizing radiation
HSZ47_RS04225	COG3091	SprT-like family
HSZ47_RS04255	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HSZ47_RS04260	COG0066	3-isopropylmalate dehydratase activity
HSZ47_RS04265	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HSZ47_RS04270	COG0473	3-isopropylmalate dehydrogenase activity
HSZ47_RS04275	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HSZ47_RS04280	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HSZ47_RS04285	COG0440	acetolactate synthase activity
HSZ47_RS04290	COG0028	Belongs to the TPP enzyme family
HSZ47_RS04295	COG0129	dihydroxy-acid dehydratase activity
HSZ47_RS04300	COG0802	atpase or kinase
HSZ47_RS04305	COG1214	PFAM Peptidase M22, glycoprotease
HSZ47_RS04310	COG0456	acetyltransferase
HSZ47_RS04315	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HSZ47_RS04325	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HSZ47_RS04330	COG0488	(ABC) transporter
HSZ47_RS04335	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HSZ47_RS04340	COG2391	methyltransferase activity
HSZ47_RS04345	COG0425	Belongs to the sulfur carrier protein TusA family
HSZ47_RS04350	COG1609	Transcriptional regulator
HSZ47_RS04355	COG1621	beta-fructofuranosidase activity
HSZ47_RS04360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HSZ47_RS04365	COG3279	Response regulator of the LytR AlgR family
HSZ47_RS04370	COG3290	protein histidine kinase activity
HSZ47_RS04380	COG4512	PFAM Accessory gene regulator B
HSZ47_RS04385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HSZ47_RS04405	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HSZ47_RS04410	COG0459	protein refolding
HSZ47_RS04445	COG1725	Transcriptional regulator
HSZ47_RS04460	COG1131	(ABC) transporter
HSZ47_RS04505	COG2706	6-phosphogluconolactonase activity
HSZ47_RS04515	COG1012	belongs to the aldehyde dehydrogenase family
HSZ47_RS04520	COG1227	inorganic diphosphatase activity
HSZ47_RS04525	COG1335	isochorismatase
HSZ47_RS04535	COG0471	metal ion transport
HSZ47_RS04540	COG0077	Prephenate dehydratase
HSZ47_RS04550	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HSZ47_RS04555	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HSZ47_RS04560	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HSZ47_RS04570	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HSZ47_RS04575	COG4496	protein, YerC YecD
HSZ47_RS04585	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HSZ47_RS04595	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HSZ47_RS04600	COG4851	CamS sex pheromone cAM373 precursor
HSZ47_RS04605	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HSZ47_RS04610	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HSZ47_RS04615	COG0154	amidase activity
HSZ47_RS04620	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HSZ47_RS04625	COG1597	lipid kinase activity
HSZ47_RS04630	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HSZ47_RS04640	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HSZ47_RS04650	COG1528	Iron-storage protein
HSZ47_RS04675	COG2801	Transposase and inactivated derivatives
HSZ47_RS04680	COG2801	Transposase and inactivated derivatives
HSZ47_RS04685	COG4129	membrane
HSZ47_RS04690	COG0024	Methionine aminopeptidase
HSZ47_RS04705	COG4585	Histidine kinase
HSZ47_RS04710	COG2197	response regulator
HSZ47_RS04715	COG1295	ribonuclease BN
HSZ47_RS04725	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HSZ47_RS04730	COG4840	Belongs to the UPF0435 family
HSZ47_RS04735	COG2309	aminopeptidase activity
HSZ47_RS04740	COG1607	acyl-coa hydrolase
HSZ47_RS04745	COG0535	radical SAM domain protein
HSZ47_RS04755	COG0693	protein deglycase activity
HSZ47_RS04760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HSZ47_RS04765	COG2137	regulation of response to DNA damage stimulus
HSZ47_RS04775	COG1134	teichoic acid transport
HSZ47_RS04785	COG1988	membrane-bound metal-dependent
HSZ47_RS04795	COG3557	Belongs to the UPF0374 family
HSZ47_RS04805	COG4129	membrane
HSZ47_RS04810	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HSZ47_RS04815	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HSZ47_RS04820	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HSZ47_RS04825	COG0735	belongs to the Fur family
HSZ47_RS04970	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HSZ47_RS04985	COG0765	amino acid transport
HSZ47_RS04990	COG1126	abc transporter atp-binding protein
HSZ47_RS04995	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HSZ47_RS05005	COG0363	glucosamine-6-phosphate deaminase activity
HSZ47_RS05020	COG0114	fumarate hydratase activity
HSZ47_RS05025	COG0564	pseudouridine synthase activity
HSZ47_RS05030	COG2203	Gaf domain
HSZ47_RS05030	COG4585	Histidine kinase
HSZ47_RS05035	COG2197	response regulator
HSZ47_RS05040	COG1301	dicarboxylic acid transport
HSZ47_RS05055	COG1682	transport, permease protein
HSZ47_RS05060	COG0788	formyltetrahydrofolate deformylase activity
HSZ47_RS05070	COG4399	Belongs to the UPF0754 family
HSZ47_RS05075	COG3679	Belongs to the UPF0342 family
HSZ47_RS05080	COG0420	3'-5' exonuclease activity
HSZ47_RS05085	COG4717	serine-type aminopeptidase activity
HSZ47_RS05090	COG3481	metal-dependent phosphohydrolase, HD sub domain
HSZ47_RS05095	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HSZ47_RS05110	COG0537	adenosine 5'-monophosphoramidase activity
HSZ47_RS05115	COG1131	(ABC) transporter
HSZ47_RS05120	COG4473	ABC transporter
HSZ47_RS05130	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HSZ47_RS05145	COG3545	Serine hydrolase
HSZ47_RS05195	COG0318	PFAM AMP-dependent synthetase and ligase
HSZ47_RS05205	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HSZ47_RS05215	COG1506	peptidase
HSZ47_RS05220	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HSZ47_RS05225	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HSZ47_RS05235	COG0656	L-ascorbic acid biosynthetic process
HSZ47_RS05240	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HSZ47_RS05245	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HSZ47_RS05255	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HSZ47_RS05285	COG4193	domain, Protein
HSZ47_RS05285	COG5632	N-Acetylmuramoyl-L-alanine amidase
HSZ47_RS05285	COG3266	domain, Protein
HSZ47_RS05305	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HSZ47_RS05305	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HSZ47_RS05310	COG0307	riboflavin synthase, alpha
HSZ47_RS05315	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HSZ47_RS05315	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HSZ47_RS05320	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HSZ47_RS05330	COG2267	carboxylic ester hydrolase activity
HSZ47_RS05335	COG0039	L-malate dehydrogenase activity
HSZ47_RS05345	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HSZ47_RS05350	COG1242	4 iron, 4 sulfur cluster binding
HSZ47_RS05355	COG2814	Major facilitator Superfamily
HSZ47_RS05360	COG0495	leucyl-tRNA aminoacylation
HSZ47_RS05370	COG2081	HI0933 family
HSZ47_RS05375	COG2244	polysaccharide biosynthetic process
HSZ47_RS05380	COG1187	pseudouridine synthase activity
HSZ47_RS05390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HSZ47_RS05395	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HSZ47_RS05400	COG0510	thiamine kinase activity
HSZ47_RS05405	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HSZ47_RS05410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HSZ47_RS05415	COG5584	Small secreted protein
HSZ47_RS05420	COG1363	Peptidase, m42
HSZ47_RS05425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HSZ47_RS05430	COG4848	Belongs to the UPF0354 family
HSZ47_RS05435	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HSZ47_RS05440	COG1674	ftsk spoiiie
HSZ47_RS05445	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HSZ47_RS05450	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HSZ47_RS05460	COG1605	Chorismate mutase
HSZ47_RS05460	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HSZ47_RS05465	COG1609	Transcriptional regulator
HSZ47_RS05470	COG0123	including yeast histone deacetylase and acetoin utilization protein
HSZ47_RS05475	COG0454	-acetyltransferase
HSZ47_RS05480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HSZ47_RS05490	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HSZ47_RS05495	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HSZ47_RS05500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HSZ47_RS05505	COG0204	Acyl-transferase
HSZ47_RS05510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HSZ47_RS05510	COG1263	PTS System
HSZ47_RS05520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HSZ47_RS05530	COG1764	response to oxidative stress
HSZ47_RS05535	COG0584	glycerophosphoryl diester phosphodiesterase
HSZ47_RS05545	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HSZ47_RS05550	COG1956	GAF domain-containing protein
HSZ47_RS05555	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HSZ47_RS05560	COG1104	cysteine desulfurase activity
HSZ47_RS05565	COG0301	tRNA thio-modification
HSZ47_RS05575	COG0616	signal peptide processing
HSZ47_RS05580	COG1714	RDD family
HSZ47_RS05585	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HSZ47_RS05590	COG0827	DNA restriction-modification system
HSZ47_RS05595	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HSZ47_RS05605	COG0589	response to stress
HSZ47_RS05610	COG0686	Belongs to the AlaDH PNT family
HSZ47_RS05615	COG3142	Participates in the control of copper homeostasis
HSZ47_RS05620	COG0006	proline dipeptidase activity
HSZ47_RS05625	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HSZ47_RS05635	COG4109	DRTGG domain
HSZ47_RS05640	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HSZ47_RS05645	COG0587	DNA-directed DNA polymerase activity
HSZ47_RS05650	COG0281	malic enzyme
HSZ47_RS05655	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HSZ47_RS05660	COG0825	malonyl-CoA metabolic process
HSZ47_RS05665	COG0205	6-phosphofructokinase activity
HSZ47_RS05670	COG0469	pyruvate kinase activity
HSZ47_RS05675	COG1113	amino acid transport
HSZ47_RS05680	COG0372	Belongs to the citrate synthase family
HSZ47_RS05685	COG0538	isocitrate dehydrogenase activity
HSZ47_RS05690	COG0745	RESPONSE REGULATOR receiver
HSZ47_RS05695	COG5002	protein histidine kinase activity
HSZ47_RS05700	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HSZ47_RS05700	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HSZ47_RS05705	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HSZ47_RS05710	COG0237	dephospho-CoA kinase activity
HSZ47_RS05715	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HSZ47_RS05720	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HSZ47_RS05730	COG1484	DNA-dependent DNA replication
HSZ47_RS05735	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HSZ47_RS05740	COG0833	amino acid
HSZ47_RS05745	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HSZ47_RS05750	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HSZ47_RS05755	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HSZ47_RS05760	COG4112	unkown
HSZ47_RS05770	COG0544	peptidyl-prolyl cis-trans isomerase activity
HSZ47_RS05775	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HSZ47_RS05780	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HSZ47_RS05785	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HSZ47_RS05790	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HSZ47_RS05795	COG0181	hydroxymethylbilane synthase activity
HSZ47_RS05805	COG0113	porphobilinogen synthase activity
HSZ47_RS05810	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HSZ47_RS05825	COG2818	Glycosylase
HSZ47_RS05830	COG0525	valine-tRNA ligase activity
HSZ47_RS05835	COG0285	dihydrofolate synthase activity
HSZ47_RS05845	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HSZ47_RS05850	COG2003	Belongs to the UPF0758 family
HSZ47_RS05885	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HSZ47_RS05890	COG2868	ribosomal protein
HSZ47_RS05895	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HSZ47_RS05900	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HSZ47_RS05905	COG4492	Belongs to the UPF0735 family
HSZ47_RS05910	COG0632	four-way junction helicase activity
HSZ47_RS05915	COG2255	four-way junction helicase activity
HSZ47_RS05920	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HSZ47_RS05925	COG0343	queuine tRNA-ribosyltransferase activity
HSZ47_RS05930	COG1862	Preprotein translocase
HSZ47_RS05935	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HSZ47_RS05935	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HSZ47_RS05940	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HSZ47_RS05940	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HSZ47_RS05945	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HSZ47_RS05955	COG1490	D-aminoacyl-tRNA deacylase activity
HSZ47_RS05960	COG0860	N-Acetylmuramoyl-L-alanine amidase
HSZ47_RS05965	COG0124	histidyl-tRNA synthetase
HSZ47_RS05970	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HSZ47_RS05980	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HSZ47_RS05985	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HSZ47_RS05990	COG1959	2 iron, 2 sulfur cluster binding
HSZ47_RS05995	COG3237	CsbD-like
HSZ47_RS06005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HSZ47_RS06010	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HSZ47_RS06025	COG1104	cysteine desulfurase activity
HSZ47_RS06030	COG0482	sulfurtransferase activity
HSZ47_RS06040	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HSZ47_RS06045	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HSZ47_RS06050	COG4472	Bacterial protein of unknown function (DUF965)
HSZ47_RS06055	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HSZ47_RS06060	COG3906	Belongs to the UPF0473 family
HSZ47_RS06065	COG4122	O-methyltransferase activity
HSZ47_RS06080	COG0572	uridine kinase
HSZ47_RS06085	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HSZ47_RS06090	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HSZ47_RS06095	COG1984	allophanate hydrolase subunit 2
HSZ47_RS06105	COG0439	Biotin carboxylase
HSZ47_RS06110	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HSZ47_RS06115	COG1914	H( )-stimulated, divalent metal cation uptake system
HSZ47_RS06120	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HSZ47_RS06125	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HSZ47_RS06130	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HSZ47_RS06135	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HSZ47_RS06140	COG1534	Rna-binding protein
HSZ47_RS06145	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HSZ47_RS06150	COG1713	HD superfamily hydrolase involved in NAD metabolism
HSZ47_RS06155	COG0799	negative regulation of ribosome biogenesis
HSZ47_RS06160	COG2226	methyltransferase
HSZ47_RS06165	COG1555	photosystem II stabilization
HSZ47_RS06165	COG1596	polysaccharide export
HSZ47_RS06170	COG2131	deaminase
HSZ47_RS06175	COG0658	competence protein
HSZ47_RS06175	COG2333	competence protein COMEC
HSZ47_RS06180	COG1466	dna polymerase III delta subunit
HSZ47_RS06185	COG0268	Binds directly to 16S ribosomal RNA
HSZ47_RS06190	COG0481	GTPase activity
HSZ47_RS06195	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HSZ47_RS06200	COG1420	regulation of RNA biosynthetic process
HSZ47_RS06205	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HSZ47_RS06210	COG0443	Heat shock 70 kDa protein
HSZ47_RS06215	COG0484	heat shock protein binding
HSZ47_RS06220	COG2264	protein methyltransferase activity
HSZ47_RS06225	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HSZ47_RS06230	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HSZ47_RS06235	COG1030	water channel activity
HSZ47_RS06240	COG4864	UPF0365 protein
HSZ47_RS06250	COG1702	phosphate starvation-inducible protein PhoH
HSZ47_RS06255	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HSZ47_RS06265	COG0295	cytidine deaminase activity
HSZ47_RS06270	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HSZ47_RS06275	COG1381	Involved in DNA repair and RecF pathway recombination
HSZ47_RS06280	COG0423	glycine-tRNA ligase activity
HSZ47_RS06285	COG0517	IMP dehydrogenase activity
HSZ47_RS06290	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HSZ47_RS06300	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HSZ47_RS06305	COG2384	SAM-dependent methyltransferase
HSZ47_RS06310	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HSZ47_RS06315	COG0513	Belongs to the DEAD box helicase family
HSZ47_RS06320	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HSZ47_RS06325	COG1121	(ABC) transporter
HSZ47_RS06330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HSZ47_RS06340	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HSZ47_RS06350	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HSZ47_RS06355	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HSZ47_RS06360	COG0705	Rhomboid family
HSZ47_RS06360	COG0457	Tetratricopeptide repeat
HSZ47_RS06365	COG4483	Protein conserved in bacteria
HSZ47_RS06370	COG1940	carbohydrate kinase activity
HSZ47_RS06375	COG0011	TIGRFAM Protein of
HSZ47_RS06380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HSZ47_RS06385	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HSZ47_RS06390	COG1459	type II secretion system
HSZ47_RS06395	COG4537	Required for transformation and DNA binding
HSZ47_RS06410	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HSZ47_RS06415	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HSZ47_RS06420	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HSZ47_RS06425	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HSZ47_RS06430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HSZ47_RS06435	COG0095	Lipoate-protein ligase
HSZ47_RS06450	COG0006	proline dipeptidase activity
HSZ47_RS06455	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HSZ47_RS06460	COG0511	ligase activity, forming carbon-carbon bonds
HSZ47_RS06465	COG0439	Biotin carboxylase
HSZ47_RS06470	COG1302	Protein conserved in bacteria
HSZ47_RS06475	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HSZ47_RS06480	COG1570	exodeoxyribonuclease VII activity
HSZ47_RS06485	COG1722	exodeoxyribonuclease VII activity
HSZ47_RS06500	COG1438	arginine binding
HSZ47_RS06505	COG0497	DNA recombination
HSZ47_RS06510	COG0280	phosphate acetyltransferase
HSZ47_RS06515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HSZ47_RS06520	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HSZ47_RS06525	COG0022	dehydrogenase e1 component
HSZ47_RS06530	COG0508	dehydrogenase complex catalyzes the overall conversion of
HSZ47_RS06540	COG4129	membrane
HSZ47_RS06550	COG2195	Cleaves the N-terminal amino acid of tripeptides
HSZ47_RS06560	COG1609	Transcriptional regulator
HSZ47_RS06565	COG0366	Alpha amylase catalytic
HSZ47_RS06575	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HSZ47_RS06580	COG1234	tRNA 3'-trailer cleavage
HSZ47_RS06585	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HSZ47_RS06595	COG0667	Aldo Keto reductase
HSZ47_RS06600	COG0494	nUDIX hydrolase
HSZ47_RS06605	COG0735	belongs to the Fur family
HSZ47_RS06610	COG4974	Belongs to the 'phage' integrase family
HSZ47_RS06620	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HSZ47_RS06625	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HSZ47_RS06630	COG1187	pseudouridine synthase activity
HSZ47_RS06635	COG0745	RESPONSE REGULATOR receiver
HSZ47_RS06650	COG1141	Ferredoxin
HSZ47_RS06660	COG0514	ATP-dependent DNA helicase (RecQ)
HSZ47_RS06665	COG1388	LysM domain
HSZ47_RS06670	COG0492	ferredoxin-NADP+ reductase activity
HSZ47_RS06680	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HSZ47_RS06685	COG0539	negative regulation of cytoplasmic translation
HSZ47_RS06690	COG1160	GTP binding
HSZ47_RS06695	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HSZ47_RS06710	COG2226	methyltransferase
HSZ47_RS06715	COG0142	geranyltranstransferase activity
HSZ47_RS06720	COG0105	UTP biosynthetic process
HSZ47_RS06725	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HSZ47_RS06730	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HSZ47_RS06735	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HSZ47_RS06750	COG4347	Protein of unknown function (DUF1405)
HSZ47_RS06755	COG2738	Putative neutral zinc metallopeptidase
HSZ47_RS06760	COG1694	Mazg nucleotide pyrophosphohydrolase
HSZ47_RS06765	COG0438	transferase activity, transferring glycosyl groups
HSZ47_RS06770	COG0617	tRNA 3'-terminal CCA addition
HSZ47_RS06775	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HSZ47_RS06775	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HSZ47_RS06780	COG1199	ATP-dependent helicase activity
HSZ47_RS06780	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HSZ47_RS06785	COG0017	Asparaginyl-tRNA synthetase
HSZ47_RS06790	COG3935	DnaD domain protein
HSZ47_RS06795	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HSZ47_RS06805	COG4499	WXG100 protein secretion system (Wss), protein YukC
HSZ47_RS06805	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HSZ47_RS06810	COG3331	DNA recombination
HSZ47_RS06820	COG4474	Belongs to the UPF0398 family
HSZ47_RS06825	COG3599	regulation of cell shape
HSZ47_RS06835	COG0116	Belongs to the methyltransferase superfamily
HSZ47_RS06840	COG2962	Rard protein
HSZ47_RS06855	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HSZ47_RS06860	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HSZ47_RS06865	COG0328	RNA-DNA hybrid ribonuclease activity
HSZ47_RS06870	COG3545	Serine hydrolase
HSZ47_RS06875	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HSZ47_RS06885	COG1413	lyase activity
HSZ47_RS06890	COG1413	lyase activity
HSZ47_RS06900	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HSZ47_RS06920	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HSZ47_RS06930	COG4479	Belongs to the UPF0346 family
HSZ47_RS06935	COG0793	Belongs to the peptidase S41A family
HSZ47_RS06945	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HSZ47_RS06950	COG0671	phosphoesterase, PA-phosphatase related
HSZ47_RS06955	COG0745	RESPONSE REGULATOR receiver
HSZ47_RS06960	COG5002	protein histidine kinase activity
HSZ47_RS06965	COG0567	Dehydrogenase, E1 component
HSZ47_RS06970	COG0508	dehydrogenase complex catalyzes the overall conversion of
HSZ47_RS07010	COG0673	inositol 2-dehydrogenase activity
HSZ47_RS07015	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HSZ47_RS07020	COG0488	(ABC) transporter
HSZ47_RS07040	COG0714	Associated with various cellular activities
HSZ47_RS07045	COG4548	von Willebrand factor, type A
HSZ47_RS07050	COG1114	Component of the transport system for branched-chain amino acids
HSZ47_RS07055	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HSZ47_RS07060	COG3853	Toxic anion resistance protein (TelA)
HSZ47_RS07070	COG1254	Belongs to the acylphosphatase family
HSZ47_RS07080	COG1278	Cold shock
HSZ47_RS07095	COG1473	amidohydrolase
HSZ47_RS07100	COG2171	N-acyltransferase activity
HSZ47_RS07105	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HSZ47_RS07110	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HSZ47_RS07115	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HSZ47_RS07120	COG0527	aspartate kinase activity
HSZ47_RS07130	COG0488	(ABC) transporter
HSZ47_RS07135	COG2996	Protein conserved in bacteria
HSZ47_RS07140	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HSZ47_RS07145	COG0573	inorganic phosphate transmembrane transporter activity
HSZ47_RS07150	COG0581	inorganic phosphate transmembrane transporter activity
HSZ47_RS07155	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HSZ47_RS07160	COG0704	Plays a role in the regulation of phosphate uptake
HSZ47_RS07165	COG1164	Oligoendopeptidase f
HSZ47_RS07175	COG4607	ABC-type enterochelin transport system periplasmic component
HSZ47_RS07185	COG2348	transferase activity, transferring amino-acyl groups
HSZ47_RS07190	COG2348	transferase activity, transferring amino-acyl groups
HSZ47_RS07200	COG0159	tryptophan synthase activity
HSZ47_RS07205	COG0133	tryptophan synthase activity
HSZ47_RS07210	COG0135	phosphoribosylanthranilate isomerase activity
HSZ47_RS07215	COG0134	indole-3-glycerol-phosphate synthase activity
HSZ47_RS07220	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HSZ47_RS07225	COG0512	Glutamine amidotransferase of anthranilate synthase
HSZ47_RS07230	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HSZ47_RS07240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HSZ47_RS07245	COG1363	Peptidase, m42
HSZ47_RS07260	COG0287	Prephenate dehydrogenase
HSZ47_RS07265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HSZ47_RS07270	COG1942	4-Oxalocrotonate Tautomerase
HSZ47_RS07285	COG1879	ABC-type sugar transport system periplasmic component
HSZ47_RS07290	COG1172	Belongs to the binding-protein-dependent transport system permease family
HSZ47_RS07295	COG1129	ABC transporter
HSZ47_RS07300	COG1869	D-ribose catabolic process
HSZ47_RS07305	COG1609	Transcriptional regulator
HSZ47_RS07310	COG0392	lysyltransferase activity
HSZ47_RS07310	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HSZ47_RS07315	COG0628	permease
HSZ47_RS07330	COG3711	transcriptional antiterminator
HSZ47_RS07335	COG1115	amino acid carrier protein
HSZ47_RS07340	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HSZ47_RS07350	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HSZ47_RS07355	COG4841	protein insertion into membrane
HSZ47_RS07360	COG0824	Thioesterase
HSZ47_RS07365	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HSZ47_RS07370	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HSZ47_RS07375	COG1970	mechanosensitive ion channel activity
HSZ47_RS07380	COG0419	ATPase involved in DNA repair
HSZ47_RS07385	COG0420	3'-5' exonuclease activity
HSZ47_RS07390	COG4846	Membrane protein involved in cytochrome C biogenesis
HSZ47_RS07405	COG3763	UPF0154 protein
HSZ47_RS07425	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HSZ47_RS07435	COG0516	GMP reductase activity
HSZ47_RS07440	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HSZ47_RS07445	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HSZ47_RS07450	COG0753	catalase activity
HSZ47_RS07455	COG0833	amino acid
HSZ47_RS07465	COG0561	phosphatase activity
HSZ47_RS07470	COG0083	homoserine kinase activity
HSZ47_RS07475	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HSZ47_RS07480	COG0460	homoserine dehydrogenase
HSZ47_RS07485	COG0527	aspartate kinase activity
HSZ47_RS07515	COG2197	response regulator
HSZ47_RS07520	COG4585	Histidine kinase
HSZ47_RS07520	COG2203	Gaf domain
HSZ47_RS07525	COG0842	Transport permease protein
HSZ47_RS07530	COG1131	(ABC) transporter
HSZ47_RS07540	COG0174	glutamine synthetase
HSZ47_RS07545	COG0789	Transcriptional regulator
HSZ47_RS07550	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HSZ47_RS07555	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HSZ47_RS07560	COG0386	Belongs to the glutathione peroxidase family
HSZ47_RS07565	COG1923	regulation of RNA biosynthetic process
HSZ47_RS07570	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HSZ47_RS07580	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HSZ47_RS07585	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HSZ47_RS07590	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HSZ47_RS07605	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HSZ47_RS07610	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HSZ47_RS07620	COG4550	Control of competence regulator ComK, YlbF/YmcA
HSZ47_RS07625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HSZ47_RS07650	COG1013	pyruvate-flavodoxin oxidoreductase activity
HSZ47_RS07655	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HSZ47_RS07655	COG0674	pyruvate-flavodoxin oxidoreductase activity
HSZ47_RS07660	COG1692	metallophosphoesterase
HSZ47_RS07670	COG1418	mRNA catabolic process
HSZ47_RS07675	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HSZ47_RS07680	COG1546	Belongs to the CinA family
HSZ47_RS07680	COG1058	Belongs to the CinA family
HSZ47_RS07700	COG0300	oxidoreductase activity
HSZ47_RS07705	COG0612	Peptidase, M16
HSZ47_RS07710	COG0612	Peptidase, M16
HSZ47_RS07715	COG2188	Transcriptional regulator
HSZ47_RS07720	COG1674	ftsk spoiiie
HSZ47_RS07725	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HSZ47_RS07730	COG1185	polyribonucleotide nucleotidyltransferase activity
HSZ47_RS07735	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HSZ47_RS07740	COG0196	riboflavin kinase activity
HSZ47_RS07745	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HSZ47_RS07750	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HSZ47_RS07765	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HSZ47_RS07770	COG1358	cellular component organization or biogenesis
HSZ47_RS07775	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HSZ47_RS07780	COG0195	Participates in both transcription termination and antitermination
HSZ47_RS07785	COG0779	Required for maturation of 30S ribosomal subunits
HSZ47_RS07790	COG2176	DNA-directed DNA polymerase activity
HSZ47_RS07795	COG0442	prolyl-tRNA aminoacylation
HSZ47_RS07805	COG4589	Belongs to the CDS family
HSZ47_RS07810	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HSZ47_RS07815	COG0233	cytoplasmic translational termination
HSZ47_RS07820	COG0528	UMP kinase activity
HSZ47_RS07825	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HSZ47_RS07830	COG0052	Belongs to the universal ribosomal protein uS2 family
HSZ47_RS07835	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HSZ47_RS07840	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HSZ47_RS07845	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HSZ47_RS07850	COG4974	Belongs to the 'phage' integrase family
HSZ47_RS07855	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HSZ47_RS07860	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HSZ47_RS07865	COG0758	DNA mediated transformation
HSZ47_RS07875	COG0045	succinate-CoA ligase (ADP-forming) activity
HSZ47_RS07880	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HSZ47_RS07890	COG4485	Bacterial membrane protein, YfhO
HSZ47_RS07900	COG0335	large ribosomal subunit rRNA binding
HSZ47_RS07905	COG0336	Belongs to the RNA methyltransferase TrmD family
HSZ47_RS07910	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HSZ47_RS07915	COG0228	four-way junction DNA binding
HSZ47_RS07920	COG1028	Short-chain dehydrogenase reductase Sdr
HSZ47_RS07925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HSZ47_RS07930	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HSZ47_RS07935	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HSZ47_RS07940	COG0552	protein localization to endoplasmic reticulum
HSZ47_RS07945	COG1196	nuclear chromosome segregation
HSZ47_RS07950	COG0571	ribonuclease III activity
HSZ47_RS07955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HSZ47_RS07970	COG0416	fatty acid biosynthetic process
HSZ47_RS07975	COG1349	DNA-binding transcription factor activity
HSZ47_RS07985	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HSZ47_RS07990	COG1760	l-serine dehydratase
HSZ47_RS07995	COG1760	l-serine dehydratase
HSZ47_RS08000	COG1461	Dihydroxyacetone kinase
HSZ47_RS08005	COG1302	Protein conserved in bacteria
HSZ47_RS08010	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HSZ47_RS08015	COG1564	THIamine pyrophosphokinase
HSZ47_RS08020	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HSZ47_RS08025	COG1162	GTPase activity
HSZ47_RS08035	COG0631	protein serine/threonine phosphatase activity
HSZ47_RS08040	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HSZ47_RS08045	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HSZ47_RS08045	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HSZ47_RS08050	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HSZ47_RS08055	COG0242	peptide deformylase activity
HSZ47_RS08070	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HSZ47_RS08075	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HSZ47_RS08080	COG1758	RNA polymerase activity
HSZ47_RS08085	COG0194	GDP metabolic process
HSZ47_RS08090	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HSZ47_RS08100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HSZ47_RS08110	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HSZ47_RS08115	COG0284	orotidine-5'-phosphate decarboxylase activity
HSZ47_RS08120	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HSZ47_RS08125	COG0505	Belongs to the CarA family
HSZ47_RS08135	COG0540	Belongs to the ATCase OTCase family
HSZ47_RS08145	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HSZ47_RS08150	COG0564	pseudouridine synthase activity
HSZ47_RS08155	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HSZ47_RS08165	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HSZ47_RS08170	COG3599	regulation of cell shape
HSZ47_RS08180	COG0762	integral membrane protein
HSZ47_RS08185	COG1799	cell septum assembly
HSZ47_RS08190	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HSZ47_RS08200	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HSZ47_RS08205	COG0849	cell division
HSZ47_RS08210	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HSZ47_RS08215	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HSZ47_RS08220	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HSZ47_RS08230	COG4839	cell division protein FtsL
HSZ47_RS08235	COG0275	rRNA processing
HSZ47_RS08240	COG2001	Belongs to the MraZ family
HSZ47_RS08245	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HSZ47_RS08250	COG0454	-acetyltransferase
HSZ47_RS08255	COG1011	Hydrolase
HSZ47_RS08280	COG1280	lysine exporter protein (LysE YggA)
HSZ47_RS08295	COG2801	Transposase and inactivated derivatives
HSZ47_RS08320	COG2261	transglycosylase associated protein
HSZ47_RS08430	COG0052	Belongs to the universal ribosomal protein uS2 family
HSZ47_RS08460	COG1783	phage Terminase large subunit
HSZ47_RS08535	COG3723	Recombinational DNA repair protein, rece pathway
HSZ47_RS08540	COG5377	YqaJ viral recombinase family
HSZ47_RS08580	COG1525	nuclease
HSZ47_RS08600	COG0582	viral genome integration into host DNA
HSZ47_RS08620	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HSZ47_RS08625	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HSZ47_RS08630	COG1053	succinate dehydrogenase
HSZ47_RS08635	COG2009	succinate dehydrogenase
HSZ47_RS08640	COG0322	excinuclease ABC activity
HSZ47_RS08645	COG3118	belongs to the thioredoxin family
HSZ47_RS08650	COG1193	negative regulation of DNA recombination
HSZ47_RS08655	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HSZ47_RS08655	COG1796	DNA polymerase
HSZ47_RS08665	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HSZ47_RS08670	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HSZ47_RS08675	COG0072	phenylalanine-tRNA ligase activity
HSZ47_RS08680	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HSZ47_RS08685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HSZ47_RS08695	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HSZ47_RS08705	COG1323	Belongs to the UPF0348 family
HSZ47_RS08710	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HSZ47_RS08715	COG0742	ribosomal rna small subunit methyltransferase
HSZ47_RS08730	COG0584	glycerophosphoryl diester phosphodiesterase
HSZ47_RS08735	COG3679	Belongs to the UPF0342 family
HSZ47_RS08755	COG0109	protoheme IX farnesyltransferase activity
HSZ47_RS08760	COG1612	heme a metabolic process
HSZ47_RS08770	COG0772	Belongs to the SEDS family
HSZ47_RS08775	COG4838	Belongs to the UPF0358 family
HSZ47_RS08780	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HSZ47_RS08785	COG4896	Protein conserved in bacteria
HSZ47_RS08800	COG0483	inositol monophosphate 1-phosphatase activity
HSZ47_RS08805	COG4493	Belongs to the UPF0637 family
HSZ47_RS08815	COG1914	H( )-stimulated, divalent metal cation uptake system
HSZ47_RS08830	COG1177	transmembrane transport
HSZ47_RS08835	COG1176	ABC-type spermidine putrescine transport system, permease component I
HSZ47_RS08840	COG3842	ATPase activity
HSZ47_RS08850	COG4476	Belongs to the UPF0223 family
HSZ47_RS08895	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HSZ47_RS08900	COG0569	domain protein
HSZ47_RS08905	COG1294	oxidase, subunit
HSZ47_RS08910	COG1271	oxidase subunit
HSZ47_RS08925	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HSZ47_RS08935	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HSZ47_RS08950	COG4172	Belongs to the ABC transporter superfamily
HSZ47_RS08955	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HSZ47_RS08960	COG0151	Belongs to the GarS family
HSZ47_RS08965	COG0138	bifunctional purine biosynthesis protein purh
HSZ47_RS08975	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HSZ47_RS08985	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HSZ47_RS08990	COG0047	phosphoribosylformylglycinamidine synthase activity
HSZ47_RS08995	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HSZ47_RS09000	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HSZ47_RS09005	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HSZ47_RS09010	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HSZ47_RS09015	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HSZ47_RS09020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HSZ47_RS09020	COG1017	nitric oxide dioxygenase activity
HSZ47_RS09030	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HSZ47_RS09035	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HSZ47_RS09040	COG1845	cytochrome c oxidase, subunit III
HSZ47_RS09045	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HSZ47_RS09055	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HSZ47_RS09060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HSZ47_RS09065	COG1316	TRANSCRIPTIONal
HSZ47_RS09090	COG3594	Acyltransferase
HSZ47_RS09095	COG0436	Aminotransferase
HSZ47_RS09105	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HSZ47_RS09115	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HSZ47_RS09120	COG1169	isochorismate synthase
HSZ47_RS09125	COG1575	Belongs to the MenA family. Type 1 subfamily
HSZ47_RS09135	COG2314	TM2 domain
HSZ47_RS09155	COG1764	response to oxidative stress
HSZ47_RS09170	COG4903	ComK protein
HSZ47_RS09185	COG4873	Protein conserved in bacteria
HSZ47_RS09195	COG0737	Belongs to the 5'-nucleotidase family
HSZ47_RS09200	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HSZ47_RS09205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HSZ47_RS09210	COG0861	Integral membrane protein TerC family
HSZ47_RS09215	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HSZ47_RS09225	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HSZ47_RS09230	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HSZ47_RS09235	COG2814	Major facilitator Superfamily
HSZ47_RS09240	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HSZ47_RS09245	COG2382	esterase
HSZ47_RS09250	COG1115	amino acid carrier protein
HSZ47_RS09255	COG0628	permease
HSZ47_RS09265	COG0569	domain protein
HSZ47_RS09265	COG0475	glutathione-regulated potassium exporter activity
HSZ47_RS09270	COG2239	Acts as a magnesium transporter
HSZ47_RS09275	COG0564	pseudouridine synthase activity
HSZ47_RS09280	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HSZ47_RS09285	COG2357	RelA SpoT domain protein
HSZ47_RS09295	COG4116	CYTH
HSZ47_RS09300	COG2346	COG2346, Truncated hemoglobins
HSZ47_RS09310	COG2910	NAD(P)H-binding
HSZ47_RS09315	COG1164	Oligoendopeptidase f
HSZ47_RS09325	COG4862	establishment of competence for transformation
HSZ47_RS09330	COG1393	Belongs to the ArsC family
HSZ47_RS09335	COG0180	Tryptophanyl-tRNA synthetase
HSZ47_RS09340	COG4166	transmembrane transport
HSZ47_RS09345	COG4608	Belongs to the ABC transporter superfamily
HSZ47_RS09350	COG0444	Belongs to the ABC transporter superfamily
HSZ47_RS09355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HSZ47_RS09360	COG0601	transmembrane transport
HSZ47_RS09380	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HSZ47_RS09390	COG0542	response to heat
HSZ47_RS09405	COG0561	phosphatase activity
HSZ47_RS09410	COG0446	pyridine nucleotide-disulphide oxidoreductase
HSZ47_RS09420	COG0179	Fumarylacetoacetate (FAA) hydrolase
HSZ47_RS09425	COG2311	Membrane
HSZ47_RS09430	COG1074	ATP-dependent DNA helicase activity
HSZ47_RS09435	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HSZ47_RS09450	COG0398	Pfam SNARE associated Golgi protein
HSZ47_RS09455	COG0166	Belongs to the GPI family
HSZ47_RS09460	COG0137	argininosuccinate synthase activity
HSZ47_RS09465	COG0165	Argininosuccinate lyase
HSZ47_RS09470	COG0584	glycerophosphoryl diester phosphodiesterase
HSZ47_RS09480	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HSZ47_RS09485	COG1902	pentaerythritol trinitrate reductase activity
HSZ47_RS09490	COG1098	S1 RNA binding domain
HSZ47_RS09495	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HSZ47_RS09505	COG2111	Na H antiporter
HSZ47_RS09505	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HSZ47_RS09510	COG2111	Na H antiporter
HSZ47_RS09515	COG1006	Multisubunit Na H antiporter MnhC subunit
HSZ47_RS09520	COG0651	ATP synthesis coupled electron transport
HSZ47_RS09525	COG1863	multisubunit Na H antiporter MnhE subunit
HSZ47_RS09530	COG2212	antiporter activity
HSZ47_RS09535	COG1320	monovalent cation:proton antiporter activity
HSZ47_RS09545	COG2050	protein possibly involved in aromatic compounds catabolism
HSZ47_RS09550	COG2056	Na+-H+ antiporter family
HSZ47_RS09555	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HSZ47_RS09560	COG1252	NADH dehydrogenase
HSZ47_RS09565	COG0316	Belongs to the HesB IscA family
HSZ47_RS09570	COG4844	belongs to the
HSZ47_RS09575	COG1252	NADH dehydrogenase
HSZ47_RS09580	COG4837	Protein of unknown function (DUF1462)
HSZ47_RS09585	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HSZ47_RS09590	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HSZ47_RS09595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HSZ47_RS09600	COG1696	Membrane protein involved in D-alanine export
HSZ47_RS09605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HSZ47_RS09620	COG0647	UMP catabolic process
HSZ47_RS09625	COG2445	Protein of unknown function DUF86
HSZ47_RS09635	COG4470	Protein conserved in bacteria
HSZ47_RS09640	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HSZ47_RS09645	COG0737	Belongs to the 5'-nucleotidase family
HSZ47_RS09650	COG0730	response to heat
HSZ47_RS09655	COG1801	Protein of unknown function DUF72
HSZ47_RS09660	COG2070	2-Nitropropane dioxygenase
HSZ47_RS09665	COG1253	flavin adenine dinucleotide binding
HSZ47_RS09675	COG0719	Fe-S assembly protein
HSZ47_RS09680	COG0822	iron-sulfur transferase activity
HSZ47_RS09685	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HSZ47_RS09690	COG0719	Fe-S assembly protein
HSZ47_RS09695	COG0396	ATPase activity
HSZ47_RS09705	COG1253	flavin adenine dinucleotide binding
HSZ47_RS09715	COG1464	Belongs to the NlpA lipoprotein family
HSZ47_RS09720	COG2011	ABC-type metal ion transport system permease component
HSZ47_RS09725	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HSZ47_RS09730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HSZ47_RS09735	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HSZ47_RS09740	COG0509	glycine decarboxylation via glycine cleavage system
HSZ47_RS09745	COG1393	Belongs to the ArsC family
HSZ47_RS09750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HSZ47_RS09755	COG0778	Nitroreductase
HSZ47_RS09760	COG0710	3-dehydroquinate dehydratase activity
HSZ47_RS09765	COG1764	response to oxidative stress
HSZ47_RS09780	COG2851	Citrate transporter
HSZ47_RS09795	COG2314	TM2 domain
HSZ47_RS09900	COG0346	lactoylglutathione lyase activity
HSZ47_RS09955	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HSZ47_RS09960	COG0557	exoribonuclease II activity
HSZ47_RS09965	COG1647	Serine aminopeptidase, S33
HSZ47_RS09970	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HSZ47_RS09980	COG0148	phosphopyruvate hydratase activity
HSZ47_RS09985	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HSZ47_RS09990	COG0149	triose-phosphate isomerase activity
HSZ47_RS09995	COG0126	phosphoglycerate kinase activity
HSZ47_RS10020	COG1090	epimerase
HSZ47_RS10030	COG0740	serine-type endopeptidase activity
HSZ47_RS10045	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HSZ47_RS10050	COG1481	regulation of sporulation
HSZ47_RS10055	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HSZ47_RS10060	COG1660	Displays ATPase and GTPase activities
HSZ47_RS10065	COG0492	ferredoxin-NADP+ reductase activity
HSZ47_RS10075	COG0110	maltose O-acetyltransferase activity
HSZ47_RS10080	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HSZ47_RS10085	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HSZ47_RS10095	COG0556	nucleotide-excision repair
HSZ47_RS10110	COG1388	LysM domain
HSZ47_RS10110	COG3942	CHAP domain
HSZ47_RS10120	COG0653	protein targeting
HSZ47_RS10125	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HSZ47_RS10130	COG1040	competence protein
HSZ47_RS10135	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HSZ47_RS10145	COG1739	Uncharacterized protein family UPF0029
HSZ47_RS10150	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HSZ47_RS10155	COG2199	diguanylate cyclase activity
HSZ47_RS10170	COG2195	Cleaves the N-terminal amino acid of tripeptides
HSZ47_RS10175	COG1929	Belongs to the glycerate kinase type-1 family
HSZ47_RS10195	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HSZ47_RS10210	COG4607	ABC-type enterochelin transport system periplasmic component
HSZ47_RS10215	COG4604	ABC transporter, ATP-binding protein
HSZ47_RS10220	COG4605	iron ion homeostasis
HSZ47_RS10225	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HSZ47_RS10230	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HSZ47_RS10235	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HSZ47_RS10240	COG1780	Probably involved in ribonucleotide reductase function
HSZ47_RS10250	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HSZ47_RS10255	COG3104	oligopeptide transport
HSZ47_RS10260	COG3104	oligopeptide transport
HSZ47_RS10265	COG1597	lipid kinase activity
HSZ47_RS10275	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HSZ47_RS10280	COG1174	glycine betaine transport
HSZ47_RS10290	COG0514	ATP-dependent DNA helicase (RecQ)
HSZ47_RS10295	COG0488	(ABC) transporter
HSZ47_RS10305	COG1368	sulfuric ester hydrolase activity
HSZ47_RS10315	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HSZ47_RS10330	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HSZ47_RS10335	COG0512	Glutamine amidotransferase of anthranilate synthase
HSZ47_RS10335	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HSZ47_RS10340	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HSZ47_RS10345	COG0720	synthase
HSZ47_RS10350	COG0602	queuosine metabolic process
HSZ47_RS10365	COG0463	Glycosyl transferase, family 2
HSZ47_RS10370	COG0656	L-ascorbic acid biosynthetic process
HSZ47_RS10375	COG1253	flavin adenine dinucleotide binding
HSZ47_RS10380	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HSZ47_RS10385	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HSZ47_RS10385	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HSZ47_RS10385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HSZ47_RS10390	COG1105	Belongs to the carbohydrate kinase PfkB family
HSZ47_RS10395	COG1349	DNA-binding transcription factor activity
HSZ47_RS10400	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HSZ47_RS10405	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HSZ47_RS10430	COG0039	L-malate dehydrogenase activity
HSZ47_RS10435	COG0586	Pfam SNARE associated Golgi protein
HSZ47_RS10445	COG4989	oxidoreductase activity
HSZ47_RS10460	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HSZ47_RS10465	COG4988	ABC transporter
HSZ47_RS10470	COG1968	undecaprenyl-diphosphatase activity
HSZ47_RS10480	COG1671	Belongs to the UPF0178 family
HSZ47_RS10485	COG1611	Belongs to the LOG family
HSZ47_RS10490	COG1279	arginine transmembrane transporter activity
HSZ47_RS10495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HSZ47_RS10530	COG2814	Major facilitator Superfamily
HSZ47_RS10535	COG2839	Protein conserved in bacteria
HSZ47_RS10540	COG2814	Major facilitator Superfamily
HSZ47_RS10545	COG0583	DNA-binding transcription factor activity
HSZ47_RS10555	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HSZ47_RS10565	COG0217	transcriptional regulatory protein
HSZ47_RS10585	COG3942	CHAP domain
HSZ47_RS10585	COG1388	LysM domain
HSZ47_RS10590	COG0306	phosphate transporter
HSZ47_RS10595	COG1392	Phosphate transport regulator
HSZ47_RS10600	COG2205	protein histidine kinase activity
HSZ47_RS10605	COG0745	RESPONSE REGULATOR receiver
HSZ47_RS10610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HSZ47_RS10625	COG3949	Membrane
HSZ47_RS10635	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HSZ47_RS10640	COG1461	Dihydroxyacetone kinase
HSZ47_RS10645	COG2376	Dihydroxyacetone kinase
HSZ47_RS10650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HSZ47_RS10655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HSZ47_RS10660	COG1120	ATPase activity
HSZ47_RS10665	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HSZ47_RS10670	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HSZ47_RS10675	COG1132	(ABC) transporter
HSZ47_RS10685	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HSZ47_RS10690	COG1442	glycosyl transferase family 8
HSZ47_RS10690	COG1216	Glycosyl transferase, family 2
HSZ47_RS10695	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HSZ47_RS10700	COG1682	transport, permease protein
HSZ47_RS10705	COG1134	teichoic acid transport
HSZ47_RS10710	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HSZ47_RS10725	COG1121	(ABC) transporter
HSZ47_RS10730	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HSZ47_RS10735	COG0803	Belongs to the bacterial solute-binding protein 9 family
HSZ47_RS10745	COG1320	monovalent cation:proton antiporter activity
HSZ47_RS10750	COG2212	antiporter activity
HSZ47_RS10755	COG1863	multisubunit Na H antiporter MnhE subunit
HSZ47_RS10760	COG0651	ATP synthesis coupled electron transport
HSZ47_RS10765	COG1006	Multisubunit Na H antiporter MnhC subunit
HSZ47_RS10770	COG2111	Na H antiporter
HSZ47_RS10775	COG2111	Na H antiporter
HSZ47_RS10775	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HSZ47_RS10815	COG0596	Alpha beta hydrolase
HSZ47_RS10830	COG2267	carboxylic ester hydrolase activity
HSZ47_RS10835	COG0546	phosphoglycolate phosphatase activity
HSZ47_RS10840	COG4139	cobalamin transport
HSZ47_RS10845	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HSZ47_RS10850	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HSZ47_RS10855	COG0018	arginyl-trna synthetase
HSZ47_RS10870	COG1078	dGTPase activity
HSZ47_RS10875	COG0456	acetyltransferase
HSZ47_RS10880	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HSZ47_RS10885	COG0667	Aldo Keto reductase
HSZ47_RS10890	COG4844	belongs to the
HSZ47_RS10905	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HSZ47_RS10910	COG0095	Lipoate-protein ligase
HSZ47_RS10915	COG0280	phosphate acetyltransferase
HSZ47_RS10940	COG1846	Transcriptional regulator
HSZ47_RS10950	COG2363	Small membrane protein
HSZ47_RS10960	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HSZ47_RS10965	COG0351	phosphomethylpyrimidine kinase
HSZ47_RS11010	COG0183	Belongs to the thiolase family
HSZ47_RS11015	COG0318	PFAM AMP-dependent synthetase and ligase
HSZ47_RS11025	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HSZ47_RS11030	COG0363	glucosamine-6-phosphate deaminase activity
HSZ47_RS11040	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HSZ47_RS11045	COG1469	GTP cyclohydrolase I activity
HSZ47_RS11050	COG1846	Transcriptional regulator
HSZ47_RS11055	COG0431	NADPH-dependent FMN reductase
HSZ47_RS11060	COG0561	phosphatase activity
HSZ47_RS11070	COG1428	Deoxynucleoside kinase
HSZ47_RS11075	COG1428	Deoxynucleoside kinase
HSZ47_RS11085	COG0546	phosphoglycolate phosphatase activity
HSZ47_RS11105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HSZ47_RS11120	COG2814	Major facilitator Superfamily
HSZ47_RS11125	COG2824	Alkylphosphonate utilization operon protein PhnA
HSZ47_RS11135	COG1113	amino acid transport
HSZ47_RS11140	COG2040	homocysteine
HSZ47_RS11145	COG0833	amino acid
HSZ47_RS11155	COG0010	Belongs to the arginase family
HSZ47_RS11160	COG1914	H( )-stimulated, divalent metal cation uptake system
HSZ47_RS11170	COG1069	ribulokinase activity
HSZ47_RS11175	COG1063	alcohol dehydrogenase
HSZ47_RS11180	COG2814	Major facilitator Superfamily
HSZ47_RS11185	COG1349	DNA-binding transcription factor activity
HSZ47_RS11210	COG0583	DNA-binding transcription factor activity
HSZ47_RS11230	COG0667	Aldo Keto reductase
HSZ47_RS11240	COG3477	response to acidic pH
HSZ47_RS11255	COG1682	transport, permease protein
HSZ47_RS11270	COG1028	Short-chain dehydrogenase reductase Sdr
HSZ47_RS11275	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HSZ47_RS11280	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HSZ47_RS11310	COG1473	amidohydrolase
HSZ47_RS11315	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HSZ47_RS11320	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HSZ47_RS11325	COG0049	tRNA binding
HSZ47_RS11330	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HSZ47_RS11340	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HSZ47_RS11345	COG0085	RNA polymerase activity
HSZ47_RS11350	COG2813	Specifically methylates the guanine in position
HSZ47_RS11355	COG0222	ribosome binding
HSZ47_RS11360	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HSZ47_RS11365	COG0081	regulation of translation
HSZ47_RS11370	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HSZ47_RS11375	COG0250	Participates in transcription elongation, termination and antitermination
HSZ47_RS11385	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HSZ47_RS11400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HSZ47_RS11405	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HSZ47_RS11410	COG0215	cysteine-tRNA ligase activity
HSZ47_RS11415	COG1045	serine acetyltransferase
HSZ47_RS11420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HSZ47_RS11425	COG4956	integral membrane protein (PIN domain superfamily)
HSZ47_RS11430	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HSZ47_RS11435	COG0542	response to heat
HSZ47_RS11440	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HSZ47_RS11445	COG3880	PFAM UvrB UvrC protein
HSZ47_RS11450	COG4463	regulation of RNA biosynthetic process
HSZ47_RS11455	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HSZ47_RS11460	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HSZ47_RS11465	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HSZ47_RS11470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HSZ47_RS11555	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HSZ47_RS11560	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HSZ47_RS11580	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HSZ47_RS11585	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HSZ47_RS11600	COG1098	S1 RNA binding domain
HSZ47_RS11610	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HSZ47_RS11615	COG3956	TIGRFAM MazG family protein
HSZ47_RS11620	COG2244	polysaccharide biosynthetic process
HSZ47_RS11625	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HSZ47_RS11630	COG0193	aminoacyl-tRNA hydrolase activity
HSZ47_RS11635	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HSZ47_RS11640	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HSZ47_RS11645	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HSZ47_RS11650	COG2088	sporulation resulting in formation of a cellular spore
HSZ47_RS11655	COG0251	oxidation-reduction process
HSZ47_RS11660	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HSZ47_RS11665	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HSZ47_RS11670	COG4466	Protein conserved in bacteria
HSZ47_RS11675	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HSZ47_RS11680	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HSZ47_RS11685	COG0084	hydrolase, TatD family'
HSZ47_RS11690	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HSZ47_RS11690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HSZ47_RS11695	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HSZ47_RS11700	COG2827	Endonuclease containing a URI domain
HSZ47_RS11705	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HSZ47_RS11710	COG4467	Involved in initiation control of chromosome replication
HSZ47_RS11715	COG1774	PSP1 C-terminal conserved region
HSZ47_RS11720	COG0470	DNA polymerase III
HSZ47_RS11725	COG3870	Protein conserved in bacteria
HSZ47_RS11730	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HSZ47_RS11735	COG1982	Orn Lys Arg decarboxylase major
HSZ47_RS11755	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HSZ47_RS11760	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HSZ47_RS11765	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HSZ47_RS11780	COG2188	Transcriptional regulator
HSZ47_RS11785	COG0366	Alpha amylase catalytic
HSZ47_RS11790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HSZ47_RS11790	COG1263	PTS System
HSZ47_RS11800	COG0493	'glutamate synthase
HSZ47_RS11805	COG0070	glutamate synthase
HSZ47_RS11805	COG0069	glutamate synthase activity
HSZ47_RS11805	COG0067	glutamate synthase
HSZ47_RS11810	COG0583	DNA-binding transcription factor activity
HSZ47_RS11825	COG0004	ammonium transporteR
HSZ47_RS11830	COG0494	nUDIX hydrolase
HSZ47_RS11840	COG3942	CHAP domain
HSZ47_RS11840	COG1388	LysM domain
HSZ47_RS11850	COG0129	dihydroxy-acid dehydratase activity
HSZ47_RS11865	COG0733	neurotransmitter:sodium symporter activity
HSZ47_RS11870	COG1114	Component of the transport system for branched-chain amino acids
HSZ47_RS11875	COG5646	InterPro IPR014922
HSZ47_RS11895	COG2807	transmembrane transport
HSZ47_RS11900	COG0456	acetyltransferase
HSZ47_RS11900	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HSZ47_RS11905	COG2814	Major facilitator Superfamily
HSZ47_RS11910	COG0583	DNA-binding transcription factor activity
HSZ47_RS11915	COG2814	Major facilitator Superfamily
HSZ47_RS11970	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HSZ47_RS11970	COG0519	Catalyzes the synthesis of GMP from XMP
HSZ47_RS11975	COG0517	IMP dehydrogenase activity
HSZ47_RS11975	COG0516	GMP reductase activity
HSZ47_RS11980	COG2233	PERMEase
HSZ47_RS11985	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HSZ47_RS12005	COG1823	symporter activity
HSZ47_RS12015	COG0778	Nitroreductase
HSZ47_RS12020	COG3620	sequence-specific DNA binding
HSZ47_RS12025	COG0450	alkyl hydroperoxide reductase
HSZ47_RS12030	COG3634	alkyl hydroperoxide reductase activity
HSZ47_RS12070	COG2076	Multidrug Resistance protein
HSZ47_RS12075	COG2076	Multidrug Resistance protein
HSZ47_RS12085	COG0456	acetyltransferase
HSZ47_RS12085	COG1214	PFAM Peptidase M22, glycoprotease
HSZ47_RS12095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HSZ47_RS12115	COG4195	phage-related replication protein
HSZ47_RS12120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HSZ47_RS12130	COG1522	sequence-specific DNA binding
HSZ47_RS12195	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HSZ47_RS12205	COG0360	Binds together with S18 to 16S ribosomal RNA
HSZ47_RS12215	COG0012	GTP binding
HSZ47_RS12220	COG4481	Protein conserved in bacteria
HSZ47_RS12225	COG0668	transmembrane transport
HSZ47_RS12230	COG5609	conserved protein (DUF2294)
HSZ47_RS12235	COG3002	Belongs to the UPF0753 family
HSZ47_RS12240	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HSZ47_RS12255	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HSZ47_RS12285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HSZ47_RS12290	COG2814	Major facilitator Superfamily
HSZ47_RS12295	COG1473	amidohydrolase
HSZ47_RS12300	COG2814	Major facilitator Superfamily
HSZ47_RS12305	COG1733	regulation of RNA biosynthetic process
HSZ47_RS12310	COG3759	membrane
HSZ47_RS12315	COG2814	Major facilitator Superfamily
HSZ47_RS12340	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HSZ47_RS12350	COG0529	Catalyzes the synthesis of activated sulfate
HSZ47_RS12355	COG2046	Belongs to the sulfate adenylyltransferase family
HSZ47_RS12360	COG0730	response to heat
HSZ47_RS12380	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HSZ47_RS12385	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HSZ47_RS12390	COG0175	sulfate reduction
HSZ47_RS12405	COG1475	DNA binding
HSZ47_RS12410	COG0626	cystathionine gamma-synthase activity
HSZ47_RS12415	COG0626	cystathionine gamma-synthase activity
HSZ47_RS12420	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HSZ47_RS12420	COG0646	methionine synthase
HSZ47_RS12425	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HSZ47_RS12435	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HSZ47_RS12460	COG0183	Belongs to the thiolase family
HSZ47_RS12470	COG1960	acyl-CoA dehydrogenase activity
HSZ47_RS12475	COG0318	PFAM AMP-dependent synthetase and ligase
HSZ47_RS12485	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HSZ47_RS12495	COG0561	phosphatase activity
HSZ47_RS12510	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HSZ47_RS12515	COG1063	alcohol dehydrogenase
HSZ47_RS12520	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HSZ47_RS12525	COG0531	amino acid
HSZ47_RS12530	COG0656	L-ascorbic acid biosynthetic process
HSZ47_RS12570	COG1966	Carbon starvation protein
HSZ47_RS12575	COG1475	DNA binding
HSZ47_RS12580	COG0357	Ribosomal RNA small subunit methyltransferase G
HSZ47_RS12585	COG0445	tRNA wobble uridine modification
HSZ47_RS12590	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HSZ47_RS12595	COG0594	ribonuclease P activity
HSZ47_RS12635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HSZ47_RS12640	COG1846	Transcriptional regulator
HSZ47_RS12645	COG1063	alcohol dehydrogenase
HSZ47_RS12655	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HSZ47_RS12660	COG0693	protein deglycase activity
HSZ47_RS12665	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HSZ47_RS12670	COG1063	alcohol dehydrogenase
HSZ47_RS12675	COG0697	spore germination
HSZ47_RS12680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HSZ47_RS12685	COG1733	regulation of RNA biosynthetic process
HSZ47_RS12690	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HSZ47_RS12720	COG0583	DNA-binding transcription factor activity
HSZ47_RS12725	COG1607	acyl-coa hydrolase
HSZ47_RS12750	COG3942	CHAP domain
HSZ47_RS12750	COG1705	Flagellar rod assembly protein muramidase FlgJ
HSZ47_RS12775	COG1028	Short-chain dehydrogenase reductase Sdr
HSZ47_RS12775	COG3321	synthase
HSZ47_RS12775	COG0604	alcohol dehydrogenase
HSZ47_RS12795	COG0589	response to stress
HSZ47_RS12800	COG0659	secondary active sulfate transmembrane transporter activity
HSZ47_RS12820	COG0730	response to heat
HSZ47_RS12825	COG1937	Protein conserved in bacteria
HSZ47_RS12830	COG2210	Belongs to the sulfur carrier protein TusA family
HSZ47_RS12835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HSZ47_RS12860	COG3586	endonuclease activity
HSZ47_RS12880	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HSZ47_RS12885	COG1845	cytochrome c oxidase, subunit III
HSZ47_RS12890	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HSZ47_RS12895	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HSZ47_RS12925	COG4297	protein containing double-stranded beta helix domain
HSZ47_RS12970	COG1476	TRANSCRIPTIONal