locus-tag	class	description
HSZ48_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HSZ48_RS00010	COG0592	DNA-directed DNA polymerase activity
HSZ48_RS00015	COG2501	S4 domain
HSZ48_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HSZ48_RS00025	COG0187	DNA topoisomerase II activity
HSZ48_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HSZ48_RS00040	COG2986	histidine ammonia-lyase
HSZ48_RS00045	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HSZ48_RS00050	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HSZ48_RS00060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HSZ48_RS00070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HSZ48_RS00075	COG0359	binds to the 23S rRNA
HSZ48_RS00080	COG0305	Participates in initiation and elongation during chromosome replication
HSZ48_RS00085	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HSZ48_RS00090	COG1819	glycosyl
HSZ48_RS00110	COG0477	Major facilitator Superfamily
HSZ48_RS00115	COG0745	RESPONSE REGULATOR receiver
HSZ48_RS00120	COG5002	protein histidine kinase activity
HSZ48_RS00125	COG4863	YycH protein
HSZ48_RS00135	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HSZ48_RS00140	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HSZ48_RS00150	COG1388	LysM domain
HSZ48_RS00155	COG0730	response to heat
HSZ48_RS00160	COG1937	Protein conserved in bacteria
HSZ48_RS00165	COG2210	Belongs to the sulfur carrier protein TusA family
HSZ48_RS00170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HSZ48_RS00180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HSZ48_RS00185	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HSZ48_RS00205	COG1113	amino acid transport
HSZ48_RS00230	COG0789	Transcriptional regulator
HSZ48_RS00240	COG0702	epimerase
HSZ48_RS00245	COG2130	NADP-dependent
HSZ48_RS00280	COG2003	Belongs to the UPF0758 family
HSZ48_RS00295	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HSZ48_RS00300	COG2814	Major facilitator Superfamily
HSZ48_RS00305	COG0702	epimerase
HSZ48_RS00310	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HSZ48_RS00385	COG0789	Transcriptional regulator
HSZ48_RS00395	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HSZ48_RS00400	COG2022	thiamine diphosphate biosynthetic process
HSZ48_RS00410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HSZ48_RS00420	COG1070	Carbohydrate kinase
HSZ48_RS00430	COG2814	Major facilitator Superfamily
HSZ48_RS00475	COG0579	oxidoreductase
HSZ48_RS00480	COG0028	Belongs to the TPP enzyme family
HSZ48_RS00485	COG3527	Alpha-acetolactate decarboxylase
HSZ48_RS00490	COG1620	l-lactate permease
HSZ48_RS00495	COG0583	DNA-binding transcription factor activity
HSZ48_RS00515	COG1136	(ABC) transporter
HSZ48_RS00525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HSZ48_RS00570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HSZ48_RS00575	COG1733	regulation of RNA biosynthetic process
HSZ48_RS00580	COG2207	Transcriptional regulator
HSZ48_RS00585	COG2211	Major facilitator Superfamily
HSZ48_RS00590	COG3250	beta-galactosidase activity
HSZ48_RS00600	COG0463	Glycosyl transferase, family 2
HSZ48_RS00640	COG1028	Short-chain dehydrogenase reductase Sdr
HSZ48_RS00670	COG5002	protein histidine kinase activity
HSZ48_RS00675	COG1388	LysM domain
HSZ48_RS00680	COG1388	LysM domain
HSZ48_RS00685	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HSZ48_RS00700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HSZ48_RS00700	COG1263	PTS System
HSZ48_RS00700	COG2190	(PTS) system
HSZ48_RS00705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HSZ48_RS00705	COG2190	(PTS) system
HSZ48_RS00705	COG1263	PTS System
HSZ48_RS00750	COG1131	(ABC) transporter
HSZ48_RS00770	COG1131	(ABC) transporter
HSZ48_RS00775	COG1511	domain protein
HSZ48_RS00775	COG1511	domain protein
HSZ48_RS00800	COG1328	CTP reductase activity
HSZ48_RS00810	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HSZ48_RS00815	COG0346	lactoylglutathione lyase activity
HSZ48_RS00850	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HSZ48_RS00855	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HSZ48_RS00860	COG0579	oxidoreductase
HSZ48_RS00900	COG0477	Major facilitator Superfamily
HSZ48_RS00910	COG2814	Major facilitator Superfamily
HSZ48_RS00915	COG0583	DNA-binding transcription factor activity
HSZ48_RS00930	COG0584	glycerophosphoryl diester phosphodiesterase
HSZ48_RS00940	COG3961	Belongs to the TPP enzyme family
HSZ48_RS00950	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HSZ48_RS00955	COG1691	(AIR) carboxylase
HSZ48_RS00960	COG1606	tRNA processing
HSZ48_RS00965	COG3875	lactate racemase activity
HSZ48_RS00975	COG3835	regulator
HSZ48_RS00980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HSZ48_RS00980	COG0574	Belongs to the PEP-utilizing enzyme family
HSZ48_RS00985	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HSZ48_RS00995	COG1396	sequence-specific DNA binding
HSZ48_RS01000	COG2807	transmembrane transport
HSZ48_RS01010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HSZ48_RS01015	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HSZ48_RS01020	COG1012	belongs to the aldehyde dehydrogenase family
HSZ48_RS01025	COG0531	amino acid
HSZ48_RS01040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HSZ48_RS01050	COG1510	regulation of RNA biosynthetic process
HSZ48_RS01055	COG1012	belongs to the aldehyde dehydrogenase family
HSZ48_RS01060	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HSZ48_RS01070	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HSZ48_RS01080	COG4221	oxidoreductase activity
HSZ48_RS01095	COG0463	Glycosyl transferase, family 2
HSZ48_RS01095	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HSZ48_RS01110	COG1028	Short-chain dehydrogenase reductase Sdr
HSZ48_RS01110	COG3321	synthase
HSZ48_RS01110	COG0604	alcohol dehydrogenase
HSZ48_RS01130	COG1073	alpha beta
HSZ48_RS01140	COG0753	catalase activity
HSZ48_RS01155	COG1012	belongs to the aldehyde dehydrogenase family
HSZ48_RS01160	COG1309	transcriptional regulator
HSZ48_RS01175	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HSZ48_RS01180	COG0693	protein deglycase activity
HSZ48_RS01185	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HSZ48_RS01190	COG1063	alcohol dehydrogenase
HSZ48_RS01195	COG0697	spore germination
HSZ48_RS01200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HSZ48_RS01210	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HSZ48_RS01240	COG0583	DNA-binding transcription factor activity
HSZ48_RS01245	COG1607	acyl-coa hydrolase
HSZ48_RS01270	COG3942	CHAP domain
HSZ48_RS01270	COG1705	Flagellar rod assembly protein muramidase FlgJ
HSZ48_RS01335	COG2226	methyltransferase
HSZ48_RS01345	COG0640	Transcriptional regulator
HSZ48_RS01365	COG0583	DNA-binding transcription factor activity
HSZ48_RS01410	COG0778	Nitroreductase
HSZ48_RS01415	COG2843	Capsule synthesis protein
HSZ48_RS01420	COG1957	nucleoside hydrolase
HSZ48_RS01425	COG0477	Major facilitator Superfamily
HSZ48_RS01445	COG1131	(ABC) transporter
HSZ48_RS01455	COG0531	amino acid
HSZ48_RS01460	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HSZ48_RS01465	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HSZ48_RS01470	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HSZ48_RS01475	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HSZ48_RS01490	COG0431	NADPH-dependent FMN reductase
HSZ48_RS01495	COG3226	Transcriptional regulator
HSZ48_RS01510	COG1620	l-lactate permease
HSZ48_RS01515	COG2814	Major facilitator Superfamily
HSZ48_RS01530	COG0363	glucosamine-6-phosphate deaminase activity
HSZ48_RS01545	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HSZ48_RS01555	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HSZ48_RS01560	COG1447	Phosphotransferase system cellobiose-specific component IIA
HSZ48_RS01565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HSZ48_RS01570	COG0765	amino acid transport
HSZ48_RS01575	COG1126	abc transporter atp-binding protein
HSZ48_RS01590	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HSZ48_RS01600	COG1464	Belongs to the NlpA lipoprotein family
HSZ48_RS01605	COG0039	L-malate dehydrogenase activity
HSZ48_RS01610	COG1940	carbohydrate kinase activity
HSZ48_RS01620	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HSZ48_RS01625	COG0626	cystathionine gamma-synthase activity
HSZ48_RS01650	COG0829	nickel cation binding
HSZ48_RS01655	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HSZ48_RS01660	COG0830	nickel cation binding
HSZ48_RS01665	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HSZ48_RS01670	COG0804	urea catabolic process
HSZ48_RS01675	COG0832	Belongs to the urease beta subunit family
HSZ48_RS01680	COG0831	urea catabolic process
HSZ48_RS01685	COG4413	Urea transporter
HSZ48_RS01690	COG0747	negative chemotaxis
HSZ48_RS01715	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HSZ48_RS01725	COG0531	amino acid
HSZ48_RS01735	COG0561	phosphatase activity
HSZ48_RS01745	COG0167	dihydroorotate dehydrogenase activity
HSZ48_RS01750	COG3001	Fructosamine kinase
HSZ48_RS01775	COG0697	spore germination
HSZ48_RS01780	COG1113	amino acid transport
HSZ48_RS01800	COG3189	MarR family transcriptional regulator
HSZ48_RS01815	COG0741	lytic transglycosylase activity
HSZ48_RS01820	COG0436	Aminotransferase
HSZ48_RS01830	COG2608	mercury ion transmembrane transporter activity
HSZ48_RS01835	COG2217	Heavy metal translocating P-type atpase
HSZ48_RS01840	COG0659	secondary active sulfate transmembrane transporter activity
HSZ48_RS01845	COG1136	(ABC) transporter
HSZ48_RS01850	COG0577	efflux transmembrane transporter activity
HSZ48_RS01855	COG1028	Short-chain dehydrogenase reductase Sdr
HSZ48_RS01870	COG0471	metal ion transport
HSZ48_RS01875	COG5505	Protein of unknown function (DUF819)
HSZ48_RS01890	COG4336	lyase activity
HSZ48_RS01900	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HSZ48_RS01905	COG1012	belongs to the aldehyde dehydrogenase family
HSZ48_RS01915	COG2409	Drug exporters of the RND superfamily
HSZ48_RS01930	COG1473	amidohydrolase
HSZ48_RS01955	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HSZ48_RS01960	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HSZ48_RS01965	COG3425	synthase
HSZ48_RS01980	COG3386	PFAM SMP-30 Gluconolaconase
HSZ48_RS01985	COG3942	CHAP domain
HSZ48_RS01995	COG0583	DNA-binding transcription factor activity
HSZ48_RS02005	COG1346	cytolysis
HSZ48_RS02010	COG0028	Belongs to the TPP enzyme family
HSZ48_RS02015	COG1288	antiporter activity
HSZ48_RS02020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HSZ48_RS02020	COG2190	(PTS) system
HSZ48_RS02020	COG1263	PTS System
HSZ48_RS02030	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HSZ48_RS02040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HSZ48_RS02055	COG0697	spore germination
HSZ48_RS02065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HSZ48_RS02075	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HSZ48_RS02085	COG2843	Capsule synthesis protein
HSZ48_RS02105	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HSZ48_RS02110	COG1063	alcohol dehydrogenase
HSZ48_RS02115	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HSZ48_RS02135	COG1129	ABC transporter
HSZ48_RS02155	COG1070	Carbohydrate kinase
HSZ48_RS02160	COG1063	alcohol dehydrogenase
HSZ48_RS02170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HSZ48_RS02180	COG3764	Sortase (surface protein transpeptidase)
HSZ48_RS02185	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HSZ48_RS02190	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HSZ48_RS02200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HSZ48_RS02205	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HSZ48_RS02215	COG2249	NAD(P)H dehydrogenase (quinone) activity
HSZ48_RS02220	COG0561	phosphatase activity
HSZ48_RS02225	COG0778	Nitroreductase
HSZ48_RS02230	COG2723	6-phospho-beta-galactosidase activity
HSZ48_RS02235	COG3711	transcriptional antiterminator
HSZ48_RS02240	COG2514	catechol 2,3-dioxygenase activity
HSZ48_RS02250	COG1132	(ABC) transporter
HSZ48_RS02255	COG1132	(ABC) transporter
HSZ48_RS02275	COG1846	Transcriptional regulator
HSZ48_RS02280	COG0346	lactoylglutathione lyase activity
HSZ48_RS02285	COG0346	lactoylglutathione lyase activity
HSZ48_RS02290	COG0400	carboxylic ester hydrolase activity
HSZ48_RS02300	COG0471	metal ion transport
HSZ48_RS02305	COG3949	Membrane
HSZ48_RS02315	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HSZ48_RS02320	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HSZ48_RS02325	COG0586	Pfam SNARE associated Golgi protein
HSZ48_RS02330	COG2271	Major facilitator Superfamily
HSZ48_RS02340	COG1289	transmembrane transporter activity
HSZ48_RS02355	COG4876	unkown
HSZ48_RS02360	COG2357	RelA SpoT domain protein
HSZ48_RS02370	COG1802	Transcriptional regulator
HSZ48_RS02380	COG2610	gluconate transmembrane transporter activity
HSZ48_RS02385	COG1028	Short-chain dehydrogenase reductase Sdr
HSZ48_RS02390	COG3949	Membrane
HSZ48_RS02410	COG4221	oxidoreductase activity
HSZ48_RS02435	COG0107	imidazoleglycerol-phosphate synthase activity
HSZ48_RS02440	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HSZ48_RS02445	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HSZ48_RS02450	COG0131	Imidazoleglycerol-phosphate dehydratase
HSZ48_RS02455	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HSZ48_RS02460	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HSZ48_RS02465	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HSZ48_RS02470	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HSZ48_RS02475	COG3048	D-serine ammonia-lyase activity
HSZ48_RS02480	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HSZ48_RS02490	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HSZ48_RS02495	COG1028	Short-chain dehydrogenase reductase Sdr
HSZ48_RS02500	COG1363	Peptidase, m42
HSZ48_RS02510	COG0069	glutamate synthase activity
HSZ48_RS02520	COG4619	ABC transporter
HSZ48_RS02525	COG0390	transport system, permease component
HSZ48_RS02530	COG2814	Major facilitator Superfamily
HSZ48_RS02535	COG0531	amino acid
HSZ48_RS02540	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HSZ48_RS02550	COG3246	L-lysine catabolic process to acetate
HSZ48_RS02555	COG1250	3-hydroxyacyl-CoA dehydrogenase
HSZ48_RS02570	COG1174	glycine betaine transport
HSZ48_RS02580	COG1174	glycine betaine transport
HSZ48_RS02590	COG1960	acyl-CoA dehydrogenase activity
HSZ48_RS02595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HSZ48_RS02605	COG1116	anion transmembrane transporter activity
HSZ48_RS02615	COG1346	cytolysis
HSZ48_RS02620	COG1380	Effector of murein hydrolase LrgA
HSZ48_RS02625	COG3279	Response regulator of the LytR AlgR family
HSZ48_RS02630	COG3275	phosphorelay sensor kinase activity
HSZ48_RS02640	COG4187	Peptidase family M20/M25/M40
HSZ48_RS02660	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HSZ48_RS02675	COG0025	NhaP-type Na H and K H
HSZ48_RS02695	COG2814	Major facilitator Superfamily
HSZ48_RS02705	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HSZ48_RS02710	COG1388	LysM domain
HSZ48_RS02715	COG0588	phosphoglycerate mutase activity
HSZ48_RS02725	COG2814	Major facilitator Superfamily
HSZ48_RS02750	COG3443	Belongs to the bacterial solute-binding protein 9 family
HSZ48_RS02750	COG0803	Belongs to the bacterial solute-binding protein 9 family
HSZ48_RS02755	COG2353	YceI-like domain
HSZ48_RS02790	COG2723	6-phospho-beta-galactosidase activity
HSZ48_RS02795	COG2190	(PTS) system
HSZ48_RS02795	COG1263	PTS System
HSZ48_RS02795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HSZ48_RS02800	COG2188	Transcriptional regulator
HSZ48_RS02805	COG1959	2 iron, 2 sulfur cluster binding
HSZ48_RS02810	COG2116	formate transmembrane transporter activity
HSZ48_RS02815	COG0454	-acetyltransferase
HSZ48_RS02830	COG0071	Belongs to the small heat shock protein (HSP20) family
HSZ48_RS02840	COG1846	Transcriptional regulator
HSZ48_RS02860	COG2207	Transcriptional regulator
HSZ48_RS02870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HSZ48_RS02870	COG1263	PTS System
HSZ48_RS02895	COG1028	Short-chain dehydrogenase reductase Sdr
HSZ48_RS02900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HSZ48_RS02905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HSZ48_RS02910	COG1288	antiporter activity
HSZ48_RS02915	COG1349	DNA-binding transcription factor activity
HSZ48_RS02920	COG1063	alcohol dehydrogenase
HSZ48_RS02925	COG2376	Dihydroxyacetone kinase
HSZ48_RS02935	COG0698	ribose 5-phosphate isomerase
HSZ48_RS02945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HSZ48_RS02950	COG0492	ferredoxin-NADP+ reductase activity
HSZ48_RS02965	COG0604	alcohol dehydrogenase
HSZ48_RS02980	COG0463	Glycosyl transferase, family 2
HSZ48_RS02980	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HSZ48_RS02985	COG1620	l-lactate permease
HSZ48_RS02990	COG0438	transferase activity, transferring glycosyl groups
HSZ48_RS03000	COG5002	protein histidine kinase activity
HSZ48_RS03000	COG3850	Histidine kinase
HSZ48_RS03005	COG0745	RESPONSE REGULATOR receiver
HSZ48_RS03010	COG0577	efflux transmembrane transporter activity
HSZ48_RS03015	COG1136	(ABC) transporter
HSZ48_RS03030	COG4640	response to antibiotic
HSZ48_RS03035	COG2814	Major facilitator Superfamily
HSZ48_RS03045	COG1566	PFAM secretion protein HlyD family protein
HSZ48_RS03050	COG2814	Major facilitator Superfamily
HSZ48_RS03075	COG0598	Magnesium transport protein CorA
HSZ48_RS03080	COG1304	FMN binding
HSZ48_RS03085	COG0786	glutamate:sodium symporter activity
HSZ48_RS03100	COG1757	Na H antiporter
HSZ48_RS03105	COG2094	Belongs to the DNA glycosylase MPG family
HSZ48_RS03110	COG3152	Membrane
HSZ48_RS03115	COG1069	ribulokinase activity
HSZ48_RS03120	COG4152	abc transporter atp-binding protein
HSZ48_RS03125	COG1668	transmembrane transport
HSZ48_RS03130	COG2017	converts alpha-aldose to the beta-anomer
HSZ48_RS03135	COG2258	MOSC domain
HSZ48_RS03140	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HSZ48_RS03145	COG1266	CAAX protease self-immunity
HSZ48_RS03150	COG0010	Belongs to the arginase family
HSZ48_RS03155	COG0583	DNA-binding transcription factor activity
HSZ48_RS03160	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HSZ48_RS03165	COG1228	amidohydrolase
HSZ48_RS03170	COG0659	secondary active sulfate transmembrane transporter activity
HSZ48_RS03175	COG1473	amidohydrolase
HSZ48_RS03180	COG1028	Short-chain dehydrogenase reductase Sdr
HSZ48_RS03185	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HSZ48_RS03205	COG2801	Transposase and inactivated derivatives
HSZ48_RS03215	COG1263	PTS System
HSZ48_RS03215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HSZ48_RS03225	COG0385	Bile acid
HSZ48_RS03230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HSZ48_RS03255	COG1113	amino acid transport
HSZ48_RS03260	COG1785	Belongs to the alkaline phosphatase family
HSZ48_RS03265	COG1737	Transcriptional regulator
HSZ48_RS03270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HSZ48_RS03270	COG1263	PTS System
HSZ48_RS03275	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HSZ48_RS03295	COG0483	inositol monophosphate 1-phosphatase activity
HSZ48_RS03300	COG1316	TRANSCRIPTIONal
HSZ48_RS03305	COG3383	formate dehydrogenase (NAD+) activity
HSZ48_RS03315	COG4193	domain, Protein
HSZ48_RS03325	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HSZ48_RS03330	COG2076	Multidrug Resistance protein
HSZ48_RS03335	COG2076	Multidrug Resistance protein
HSZ48_RS03340	COG3942	CHAP domain
HSZ48_RS03355	COG1757	Na H antiporter
HSZ48_RS03360	COG3942	CHAP domain
HSZ48_RS03390	COG0765	amino acid transport
HSZ48_RS03395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HSZ48_RS03400	COG1126	abc transporter atp-binding protein
HSZ48_RS03405	COG1960	acyl-CoA dehydrogenase activity
HSZ48_RS03410	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HSZ48_RS03415	COG1268	BioY protein
HSZ48_RS03425	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HSZ48_RS03430	COG1609	Transcriptional regulator
HSZ48_RS03435	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HSZ48_RS03440	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HSZ48_RS03445	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HSZ48_RS03450	COG0725	ABC transporter, periplasmic molybdate-binding protein
HSZ48_RS03455	COG4149	molybdate abc transporter
HSZ48_RS03470	COG1510	regulation of RNA biosynthetic process
HSZ48_RS03475	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HSZ48_RS03480	COG0521	Mo-molybdopterin cofactor biosynthetic process
HSZ48_RS03485	COG0315	cyclic pyranopterin monophosphate synthase activity
HSZ48_RS03495	COG1763	Mo-molybdopterin cofactor biosynthetic process
HSZ48_RS03510	COG0746	molybdenum cofactor guanylyltransferase activity
HSZ48_RS03515	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HSZ48_RS03525	COG2814	Major facilitator Superfamily
HSZ48_RS03540	COG2348	transferase activity, transferring amino-acyl groups
HSZ48_RS03545	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HSZ48_RS03570	COG4975	Glucose uptake
HSZ48_RS03580	COG0551	DNA topoisomerase type I activity
HSZ48_RS03580	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HSZ48_RS03585	COG2252	PERMEase
HSZ48_RS03595	COG0051	transcription antitermination factor activity, RNA binding
HSZ48_RS03600	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HSZ48_RS03605	COG0088	Forms part of the polypeptide exit tunnel
HSZ48_RS03610	COG0089	rRNA binding
HSZ48_RS03615	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HSZ48_RS03620	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HSZ48_RS03625	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HSZ48_RS03630	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HSZ48_RS03635	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HSZ48_RS03640	COG0255	Belongs to the universal ribosomal protein uL29 family
HSZ48_RS03645	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HSZ48_RS03650	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HSZ48_RS03655	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HSZ48_RS03660	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HSZ48_RS03665	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HSZ48_RS03670	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HSZ48_RS03675	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HSZ48_RS03680	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HSZ48_RS03685	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HSZ48_RS03690	COG1841	ribosomal large subunit assembly
HSZ48_RS03695	COG0200	Binds to the 23S rRNA
HSZ48_RS03700	COG0201	protein transport
HSZ48_RS03705	COG0563	adenylate kinase activity
HSZ48_RS03715	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HSZ48_RS03720	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HSZ48_RS03725	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HSZ48_RS03730	COG0202	RNA polymerase activity
HSZ48_RS03735	COG0203	ribosomal protein L17
HSZ48_RS03740	COG1122	ATPase activity
HSZ48_RS03745	COG1122	ATPase activity
HSZ48_RS03755	COG0101	tRNA pseudouridine synthase activity
HSZ48_RS03760	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HSZ48_RS03765	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HSZ48_RS03775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HSZ48_RS03780	COG2130	NADP-dependent
HSZ48_RS03785	COG0604	alcohol dehydrogenase
HSZ48_RS03790	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HSZ48_RS03805	COG1302	Protein conserved in bacteria
HSZ48_RS03810	COG4264	IucA IucC family
HSZ48_RS03815	COG2814	Major facilitator Superfamily
HSZ48_RS03820	COG4264	IucA IucC family
HSZ48_RS03825	COG3457	Alanine racemase
HSZ48_RS03830	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HSZ48_RS03835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HSZ48_RS03840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HSZ48_RS03860	COG1988	membrane-bound metal-dependent
HSZ48_RS03865	COG4284	Utp--glucose-1-phosphate uridylyltransferase
HSZ48_RS03870	COG1272	protein, Hemolysin III
HSZ48_RS03885	COG0489	protein tyrosine kinase activity
HSZ48_RS03940	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HSZ48_RS03950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HSZ48_RS03955	COG0246	Mannitol dehydrogenase
HSZ48_RS03965	COG3711	transcriptional antiterminator
HSZ48_RS03970	COG2213	PTS system mannitol-specific
HSZ48_RS03985	COG1119	ATPase activity
HSZ48_RS04010	COG0640	Transcriptional regulator
HSZ48_RS04015	COG0702	epimerase
HSZ48_RS04020	COG2186	Transcriptional regulator
HSZ48_RS04025	COG1482	cell wall glycoprotein biosynthetic process
HSZ48_RS04035	COG2855	membrane
HSZ48_RS04050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HSZ48_RS04055	COG0783	Belongs to the Dps family
HSZ48_RS04065	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HSZ48_RS04070	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HSZ48_RS04075	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HSZ48_RS04085	COG1854	S-ribosylhomocysteine lyase activity
HSZ48_RS04105	COG5146	pantothenate kinase activity
HSZ48_RS04110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HSZ48_RS04115	COG3343	RNA polymerase activity
HSZ48_RS04120	COG0504	CTP synthase activity
HSZ48_RS04125	COG0191	fructose-bisphosphate aldolase activity
HSZ48_RS04130	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HSZ48_RS04140	COG1012	belongs to the aldehyde dehydrogenase family
HSZ48_RS04145	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HSZ48_RS04150	COG0254	rRNA binding
HSZ48_RS04155	COG1435	thymidine kinase activity
HSZ48_RS04160	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HSZ48_RS04165	COG2890	protein-(glutamine-N5) methyltransferase activity
HSZ48_RS04170	COG0009	L-threonylcarbamoyladenylate synthase
HSZ48_RS04175	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HSZ48_RS04180	COG4475	Protein of unknown function (DUF436)
HSZ48_RS04185	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HSZ48_RS04190	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HSZ48_RS04195	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HSZ48_RS04205	COG0356	it plays a direct role in the translocation of protons across the membrane
HSZ48_RS04210	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HSZ48_RS04215	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HSZ48_RS04220	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HSZ48_RS04225	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HSZ48_RS04230	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HSZ48_RS04235	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HSZ48_RS04240	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HSZ48_RS04250	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HSZ48_RS04255	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HSZ48_RS04265	COG0629	single-stranded DNA binding
HSZ48_RS04270	COG1388	LysM domain
HSZ48_RS04275	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HSZ48_RS04285	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HSZ48_RS04290	COG0352	thiamine-phosphate diphosphorylase activity
HSZ48_RS04295	COG0706	membrane insertase activity
HSZ48_RS04300	COG1418	mRNA catabolic process
HSZ48_RS04310	COG1937	Protein conserved in bacteria
HSZ48_RS04325	COG0772	Belongs to the SEDS family
HSZ48_RS04330	COG1181	Belongs to the D-alanine--D-alanine ligase family
HSZ48_RS04335	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HSZ48_RS04340	COG0513	Belongs to the DEAD box helicase family
HSZ48_RS04350	COG3428	Bacterial PH domain
HSZ48_RS04355	COG3402	PFAM membrane-flanked domain
HSZ48_RS04360	COG0736	holo-[acyl-carrier-protein] synthase activity
HSZ48_RS04365	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HSZ48_RS04375	COG2337	Toxic component of a toxin-antitoxin (TA) module
HSZ48_RS04380	COG2208	phosphoserine phosphatase activity
HSZ48_RS04395	COG1191	sigma factor activity
HSZ48_RS04400	COG2183	response to ionizing radiation
HSZ48_RS04405	COG3091	SprT-like family
HSZ48_RS04435	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HSZ48_RS04440	COG0066	3-isopropylmalate dehydratase activity
HSZ48_RS04445	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HSZ48_RS04450	COG0473	3-isopropylmalate dehydrogenase activity
HSZ48_RS04455	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HSZ48_RS04460	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HSZ48_RS04465	COG0440	acetolactate synthase activity
HSZ48_RS04470	COG0028	Belongs to the TPP enzyme family
HSZ48_RS04475	COG0129	dihydroxy-acid dehydratase activity
HSZ48_RS04480	COG0802	atpase or kinase
HSZ48_RS04485	COG1214	PFAM Peptidase M22, glycoprotease
HSZ48_RS04490	COG0456	acetyltransferase
HSZ48_RS04495	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HSZ48_RS04505	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HSZ48_RS04510	COG0488	(ABC) transporter
HSZ48_RS04515	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HSZ48_RS04520	COG2391	methyltransferase activity
HSZ48_RS04525	COG0425	Belongs to the sulfur carrier protein TusA family
HSZ48_RS04530	COG1609	Transcriptional regulator
HSZ48_RS04535	COG1621	beta-fructofuranosidase activity
HSZ48_RS04540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HSZ48_RS04545	COG3279	Response regulator of the LytR AlgR family
HSZ48_RS04550	COG3290	protein histidine kinase activity
HSZ48_RS04560	COG4512	PFAM Accessory gene regulator B
HSZ48_RS04565	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HSZ48_RS04585	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HSZ48_RS04620	COG1725	Transcriptional regulator
HSZ48_RS04635	COG1131	(ABC) transporter
HSZ48_RS04680	COG2706	6-phosphogluconolactonase activity
HSZ48_RS04690	COG1012	belongs to the aldehyde dehydrogenase family
HSZ48_RS04695	COG1227	inorganic diphosphatase activity
HSZ48_RS04700	COG1335	isochorismatase
HSZ48_RS04710	COG0471	metal ion transport
HSZ48_RS04715	COG0077	Prephenate dehydratase
HSZ48_RS04725	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HSZ48_RS04730	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HSZ48_RS04735	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HSZ48_RS04745	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HSZ48_RS04750	COG4496	protein, YerC YecD
HSZ48_RS04760	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HSZ48_RS04770	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HSZ48_RS04775	COG4851	CamS sex pheromone cAM373 precursor
HSZ48_RS04780	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HSZ48_RS04785	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HSZ48_RS04790	COG0154	amidase activity
HSZ48_RS04795	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HSZ48_RS04800	COG1597	lipid kinase activity
HSZ48_RS04805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HSZ48_RS04815	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HSZ48_RS04825	COG1528	Iron-storage protein
HSZ48_RS04850	COG2801	Transposase and inactivated derivatives
HSZ48_RS04855	COG4129	membrane
HSZ48_RS04860	COG0024	Methionine aminopeptidase
HSZ48_RS04875	COG4585	Histidine kinase
HSZ48_RS04880	COG2197	response regulator
HSZ48_RS04885	COG1295	ribonuclease BN
HSZ48_RS04895	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HSZ48_RS04900	COG4840	Belongs to the UPF0435 family
HSZ48_RS04905	COG2309	aminopeptidase activity
HSZ48_RS04910	COG1607	acyl-coa hydrolase
HSZ48_RS04915	COG0535	radical SAM domain protein
HSZ48_RS04925	COG0693	protein deglycase activity
HSZ48_RS04930	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HSZ48_RS04935	COG2137	regulation of response to DNA damage stimulus
HSZ48_RS04945	COG1134	teichoic acid transport
HSZ48_RS04955	COG1988	membrane-bound metal-dependent
HSZ48_RS04965	COG3557	Belongs to the UPF0374 family
HSZ48_RS04975	COG4129	membrane
HSZ48_RS04980	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HSZ48_RS04985	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HSZ48_RS04990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HSZ48_RS04995	COG0735	belongs to the Fur family
HSZ48_RS05150	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HSZ48_RS05165	COG0765	amino acid transport
HSZ48_RS05170	COG1126	abc transporter atp-binding protein
HSZ48_RS05175	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HSZ48_RS05185	COG0363	glucosamine-6-phosphate deaminase activity
HSZ48_RS05200	COG0114	fumarate hydratase activity
HSZ48_RS05205	COG0564	pseudouridine synthase activity
HSZ48_RS05210	COG2203	Gaf domain
HSZ48_RS05210	COG4585	Histidine kinase
HSZ48_RS05215	COG2197	response regulator
HSZ48_RS05220	COG1301	dicarboxylic acid transport
HSZ48_RS05230	COG1682	transport, permease protein
HSZ48_RS05235	COG0788	formyltetrahydrofolate deformylase activity
HSZ48_RS05245	COG4399	Belongs to the UPF0754 family
HSZ48_RS05250	COG3679	Belongs to the UPF0342 family
HSZ48_RS05255	COG0420	3'-5' exonuclease activity
HSZ48_RS05260	COG4717	serine-type aminopeptidase activity
HSZ48_RS05265	COG3481	metal-dependent phosphohydrolase, HD sub domain
HSZ48_RS05270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HSZ48_RS05285	COG0537	adenosine 5'-monophosphoramidase activity
HSZ48_RS05290	COG1131	(ABC) transporter
HSZ48_RS05295	COG4473	ABC transporter
HSZ48_RS05305	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HSZ48_RS05320	COG3545	Serine hydrolase
HSZ48_RS05390	COG3620	sequence-specific DNA binding
HSZ48_RS05445	COG0305	Participates in initiation and elongation during chromosome replication
HSZ48_RS05485	COG0270	DNA (cytosine-5-)-methyltransferase activity
HSZ48_RS05510	COG0756	dUTP diphosphatase activity
HSZ48_RS05565	COG0740	serine-type endopeptidase activity
HSZ48_RS05615	COG0739	heme binding
HSZ48_RS05670	COG0318	PFAM AMP-dependent synthetase and ligase
HSZ48_RS05680	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HSZ48_RS05690	COG1506	peptidase
HSZ48_RS05695	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HSZ48_RS05700	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HSZ48_RS05710	COG0656	L-ascorbic acid biosynthetic process
HSZ48_RS05715	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HSZ48_RS05720	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HSZ48_RS05730	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HSZ48_RS05760	COG5632	N-Acetylmuramoyl-L-alanine amidase
HSZ48_RS05760	COG4193	domain, Protein
HSZ48_RS05760	COG3266	domain, Protein
HSZ48_RS05780	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HSZ48_RS05780	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HSZ48_RS05785	COG0307	riboflavin synthase, alpha
HSZ48_RS05790	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HSZ48_RS05790	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HSZ48_RS05795	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HSZ48_RS05805	COG2267	carboxylic ester hydrolase activity
HSZ48_RS05810	COG0039	L-malate dehydrogenase activity
HSZ48_RS05820	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HSZ48_RS05825	COG1242	4 iron, 4 sulfur cluster binding
HSZ48_RS05830	COG2814	Major facilitator Superfamily
HSZ48_RS05835	COG0495	leucyl-tRNA aminoacylation
HSZ48_RS05845	COG2081	HI0933 family
HSZ48_RS05850	COG2244	polysaccharide biosynthetic process
HSZ48_RS05855	COG1187	pseudouridine synthase activity
HSZ48_RS05865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HSZ48_RS05870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HSZ48_RS05875	COG0510	thiamine kinase activity
HSZ48_RS05880	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HSZ48_RS05885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HSZ48_RS05890	COG5584	Small secreted protein
HSZ48_RS05895	COG1363	Peptidase, m42
HSZ48_RS05900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HSZ48_RS05905	COG4848	Belongs to the UPF0354 family
HSZ48_RS05910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HSZ48_RS05915	COG1674	ftsk spoiiie
HSZ48_RS05920	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HSZ48_RS05925	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HSZ48_RS05935	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HSZ48_RS05935	COG1605	Chorismate mutase
HSZ48_RS05940	COG1609	Transcriptional regulator
HSZ48_RS05945	COG0123	including yeast histone deacetylase and acetoin utilization protein
HSZ48_RS05950	COG0454	-acetyltransferase
HSZ48_RS05955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HSZ48_RS05960	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HSZ48_RS05965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HSZ48_RS05970	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HSZ48_RS05975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HSZ48_RS05980	COG0204	Acyl-transferase
HSZ48_RS05985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HSZ48_RS05985	COG1263	PTS System
HSZ48_RS05995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HSZ48_RS06005	COG1764	response to oxidative stress
HSZ48_RS06010	COG0584	glycerophosphoryl diester phosphodiesterase
HSZ48_RS06020	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HSZ48_RS06025	COG1956	GAF domain-containing protein
HSZ48_RS06030	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HSZ48_RS06035	COG1104	cysteine desulfurase activity
HSZ48_RS06040	COG0301	tRNA thio-modification
HSZ48_RS06050	COG0616	signal peptide processing
HSZ48_RS06055	COG1714	RDD family
HSZ48_RS06060	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HSZ48_RS06065	COG0827	DNA restriction-modification system
HSZ48_RS06070	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HSZ48_RS06080	COG0589	response to stress
HSZ48_RS06085	COG0686	Belongs to the AlaDH PNT family
HSZ48_RS06090	COG3142	Participates in the control of copper homeostasis
HSZ48_RS06095	COG0006	proline dipeptidase activity
HSZ48_RS06100	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HSZ48_RS06110	COG4109	DRTGG domain
HSZ48_RS06115	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HSZ48_RS06120	COG0587	DNA-directed DNA polymerase activity
HSZ48_RS06125	COG0281	malic enzyme
HSZ48_RS06130	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HSZ48_RS06135	COG0825	malonyl-CoA metabolic process
HSZ48_RS06140	COG0205	6-phosphofructokinase activity
HSZ48_RS06145	COG0469	pyruvate kinase activity
HSZ48_RS06150	COG1113	amino acid transport
HSZ48_RS06155	COG0372	Belongs to the citrate synthase family
HSZ48_RS06160	COG0538	isocitrate dehydrogenase activity
HSZ48_RS06165	COG0745	RESPONSE REGULATOR receiver
HSZ48_RS06170	COG5002	protein histidine kinase activity
HSZ48_RS06175	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HSZ48_RS06175	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HSZ48_RS06180	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HSZ48_RS06185	COG0237	dephospho-CoA kinase activity
HSZ48_RS06190	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HSZ48_RS06195	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HSZ48_RS06205	COG1484	DNA-dependent DNA replication
HSZ48_RS06210	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HSZ48_RS06215	COG0833	amino acid
HSZ48_RS06220	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HSZ48_RS06225	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HSZ48_RS06230	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HSZ48_RS06235	COG4112	unkown
HSZ48_RS06245	COG0544	peptidyl-prolyl cis-trans isomerase activity
HSZ48_RS06250	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HSZ48_RS06255	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HSZ48_RS06260	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HSZ48_RS06265	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HSZ48_RS06270	COG0181	hydroxymethylbilane synthase activity
HSZ48_RS06280	COG0113	porphobilinogen synthase activity
HSZ48_RS06285	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HSZ48_RS06300	COG2818	Glycosylase
HSZ48_RS06305	COG0525	valine-tRNA ligase activity
HSZ48_RS06310	COG0285	dihydrofolate synthase activity
HSZ48_RS06320	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HSZ48_RS06325	COG2003	Belongs to the UPF0758 family
HSZ48_RS06360	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HSZ48_RS06365	COG2868	ribosomal protein
HSZ48_RS06370	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HSZ48_RS06375	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HSZ48_RS06380	COG4492	Belongs to the UPF0735 family
HSZ48_RS06385	COG0632	four-way junction helicase activity
HSZ48_RS06390	COG2255	four-way junction helicase activity
HSZ48_RS06395	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HSZ48_RS06400	COG0343	queuine tRNA-ribosyltransferase activity
HSZ48_RS06405	COG1862	Preprotein translocase
HSZ48_RS06410	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HSZ48_RS06410	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HSZ48_RS06415	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HSZ48_RS06415	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HSZ48_RS06420	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HSZ48_RS06430	COG1490	D-aminoacyl-tRNA deacylase activity
HSZ48_RS06435	COG0860	N-Acetylmuramoyl-L-alanine amidase
HSZ48_RS06440	COG0124	histidyl-tRNA synthetase
HSZ48_RS06445	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HSZ48_RS06455	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HSZ48_RS06460	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HSZ48_RS06465	COG1959	2 iron, 2 sulfur cluster binding
HSZ48_RS06470	COG3237	CsbD-like
HSZ48_RS06480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HSZ48_RS06485	COG1132	(ABC) transporter
HSZ48_RS06500	COG1104	cysteine desulfurase activity
HSZ48_RS06505	COG0482	sulfurtransferase activity
HSZ48_RS06515	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HSZ48_RS06520	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HSZ48_RS06525	COG4472	Bacterial protein of unknown function (DUF965)
HSZ48_RS06530	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HSZ48_RS06535	COG3906	Belongs to the UPF0473 family
HSZ48_RS06540	COG4122	O-methyltransferase activity
HSZ48_RS06555	COG0572	uridine kinase
HSZ48_RS06560	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HSZ48_RS06565	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HSZ48_RS06570	COG1984	allophanate hydrolase subunit 2
HSZ48_RS06580	COG0439	Biotin carboxylase
HSZ48_RS06585	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HSZ48_RS06590	COG1914	H( )-stimulated, divalent metal cation uptake system
HSZ48_RS06595	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HSZ48_RS06600	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HSZ48_RS06605	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HSZ48_RS06610	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HSZ48_RS06615	COG1534	Rna-binding protein
HSZ48_RS06620	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HSZ48_RS06625	COG1713	HD superfamily hydrolase involved in NAD metabolism
HSZ48_RS06630	COG0799	negative regulation of ribosome biogenesis
HSZ48_RS06635	COG2226	methyltransferase
HSZ48_RS06640	COG1555	photosystem II stabilization
HSZ48_RS06640	COG1596	polysaccharide export
HSZ48_RS06645	COG2131	deaminase
HSZ48_RS06650	COG0658	competence protein
HSZ48_RS06650	COG2333	competence protein COMEC
HSZ48_RS06655	COG1466	dna polymerase III delta subunit
HSZ48_RS06660	COG0268	Binds directly to 16S ribosomal RNA
HSZ48_RS06665	COG0481	GTPase activity
HSZ48_RS06670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HSZ48_RS06675	COG1420	regulation of RNA biosynthetic process
HSZ48_RS06680	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HSZ48_RS06685	COG0443	Heat shock 70 kDa protein
HSZ48_RS06690	COG0484	heat shock protein binding
HSZ48_RS06695	COG2264	protein methyltransferase activity
HSZ48_RS06700	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HSZ48_RS06705	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HSZ48_RS06710	COG1030	water channel activity
HSZ48_RS06715	COG4864	UPF0365 protein
HSZ48_RS06725	COG1702	phosphate starvation-inducible protein PhoH
HSZ48_RS06730	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HSZ48_RS06740	COG0295	cytidine deaminase activity
HSZ48_RS06745	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HSZ48_RS06750	COG1381	Involved in DNA repair and RecF pathway recombination
HSZ48_RS06755	COG0423	glycine-tRNA ligase activity
HSZ48_RS06760	COG0517	IMP dehydrogenase activity
HSZ48_RS06765	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HSZ48_RS06775	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HSZ48_RS06780	COG2384	SAM-dependent methyltransferase
HSZ48_RS06785	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HSZ48_RS06790	COG0513	Belongs to the DEAD box helicase family
HSZ48_RS06795	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HSZ48_RS06800	COG1121	(ABC) transporter
HSZ48_RS06805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HSZ48_RS06815	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HSZ48_RS06825	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HSZ48_RS06830	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HSZ48_RS06835	COG0705	Rhomboid family
HSZ48_RS06835	COG0457	Tetratricopeptide repeat
HSZ48_RS06840	COG4483	Protein conserved in bacteria
HSZ48_RS06845	COG1940	carbohydrate kinase activity
HSZ48_RS06850	COG0011	TIGRFAM Protein of
HSZ48_RS06855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HSZ48_RS06860	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HSZ48_RS06865	COG1459	type II secretion system
HSZ48_RS06870	COG4537	Required for transformation and DNA binding
HSZ48_RS06885	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HSZ48_RS06890	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HSZ48_RS06895	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HSZ48_RS06900	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HSZ48_RS06905	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HSZ48_RS06910	COG0095	Lipoate-protein ligase
HSZ48_RS06925	COG0006	proline dipeptidase activity
HSZ48_RS06930	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HSZ48_RS06935	COG0511	ligase activity, forming carbon-carbon bonds
HSZ48_RS06940	COG0439	Biotin carboxylase
HSZ48_RS06945	COG1302	Protein conserved in bacteria
HSZ48_RS06950	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HSZ48_RS06955	COG1570	exodeoxyribonuclease VII activity
HSZ48_RS06960	COG1722	exodeoxyribonuclease VII activity
HSZ48_RS06975	COG1438	arginine binding
HSZ48_RS06980	COG0497	DNA recombination
HSZ48_RS06985	COG0280	phosphate acetyltransferase
HSZ48_RS06990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HSZ48_RS06995	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HSZ48_RS07000	COG0022	dehydrogenase e1 component
HSZ48_RS07005	COG0508	dehydrogenase complex catalyzes the overall conversion of
HSZ48_RS07015	COG4129	membrane
HSZ48_RS07025	COG2195	Cleaves the N-terminal amino acid of tripeptides
HSZ48_RS07035	COG1609	Transcriptional regulator
HSZ48_RS07040	COG0366	Alpha amylase catalytic
HSZ48_RS07050	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HSZ48_RS07055	COG1234	tRNA 3'-trailer cleavage
HSZ48_RS07060	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HSZ48_RS07070	COG0667	Aldo Keto reductase
HSZ48_RS07075	COG0494	nUDIX hydrolase
HSZ48_RS07080	COG0735	belongs to the Fur family
HSZ48_RS07085	COG4974	Belongs to the 'phage' integrase family
HSZ48_RS07095	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HSZ48_RS07100	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HSZ48_RS07105	COG1187	pseudouridine synthase activity
HSZ48_RS07110	COG0745	RESPONSE REGULATOR receiver
HSZ48_RS07125	COG1141	Ferredoxin
HSZ48_RS07135	COG0514	ATP-dependent DNA helicase (RecQ)
HSZ48_RS07140	COG1388	LysM domain
HSZ48_RS07145	COG0492	ferredoxin-NADP+ reductase activity
HSZ48_RS07150	COG0252	asparaginase activity
HSZ48_RS07155	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HSZ48_RS07160	COG0539	negative regulation of cytoplasmic translation
HSZ48_RS07165	COG1160	GTP binding
HSZ48_RS07170	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HSZ48_RS07185	COG2226	methyltransferase
HSZ48_RS07190	COG0142	geranyltranstransferase activity
HSZ48_RS07195	COG0105	UTP biosynthetic process
HSZ48_RS07200	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HSZ48_RS07205	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HSZ48_RS07210	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HSZ48_RS07225	COG4347	Protein of unknown function (DUF1405)
HSZ48_RS07230	COG2738	Putative neutral zinc metallopeptidase
HSZ48_RS07235	COG1694	Mazg nucleotide pyrophosphohydrolase
HSZ48_RS07240	COG0438	transferase activity, transferring glycosyl groups
HSZ48_RS07245	COG0617	tRNA 3'-terminal CCA addition
HSZ48_RS07250	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HSZ48_RS07250	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HSZ48_RS07255	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HSZ48_RS07255	COG1199	ATP-dependent helicase activity
HSZ48_RS07260	COG0017	Asparaginyl-tRNA synthetase
HSZ48_RS07265	COG3935	DnaD domain protein
HSZ48_RS07270	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HSZ48_RS07280	COG4499	WXG100 protein secretion system (Wss), protein YukC
HSZ48_RS07280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HSZ48_RS07285	COG3331	DNA recombination
HSZ48_RS07295	COG4474	Belongs to the UPF0398 family
HSZ48_RS07300	COG3599	regulation of cell shape
HSZ48_RS07310	COG0116	Belongs to the methyltransferase superfamily
HSZ48_RS07315	COG2962	Rard protein
HSZ48_RS07330	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HSZ48_RS07335	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HSZ48_RS07340	COG0328	RNA-DNA hybrid ribonuclease activity
HSZ48_RS07345	COG3545	Serine hydrolase
HSZ48_RS07350	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HSZ48_RS07360	COG1413	lyase activity
HSZ48_RS07365	COG1413	lyase activity
HSZ48_RS07375	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HSZ48_RS07395	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HSZ48_RS07405	COG4479	Belongs to the UPF0346 family
HSZ48_RS07410	COG0793	Belongs to the peptidase S41A family
HSZ48_RS07420	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HSZ48_RS07425	COG0671	phosphoesterase, PA-phosphatase related
HSZ48_RS07430	COG0745	RESPONSE REGULATOR receiver
HSZ48_RS07435	COG5002	protein histidine kinase activity
HSZ48_RS07440	COG0567	Dehydrogenase, E1 component
HSZ48_RS07445	COG0508	dehydrogenase complex catalyzes the overall conversion of
HSZ48_RS07485	COG0673	inositol 2-dehydrogenase activity
HSZ48_RS07490	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HSZ48_RS07495	COG1121	(ABC) transporter
HSZ48_RS07515	COG0714	Associated with various cellular activities
HSZ48_RS07520	COG4548	von Willebrand factor, type A
HSZ48_RS07525	COG1114	Component of the transport system for branched-chain amino acids
HSZ48_RS07530	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HSZ48_RS07535	COG3853	Toxic anion resistance protein (TelA)
HSZ48_RS07545	COG1254	Belongs to the acylphosphatase family
HSZ48_RS07555	COG1278	Cold shock
HSZ48_RS07570	COG1473	amidohydrolase
HSZ48_RS07575	COG2171	N-acyltransferase activity
HSZ48_RS07580	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HSZ48_RS07585	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HSZ48_RS07590	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HSZ48_RS07595	COG0527	aspartate kinase activity
HSZ48_RS07605	COG0488	(ABC) transporter
HSZ48_RS07610	COG2996	Protein conserved in bacteria
HSZ48_RS07615	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HSZ48_RS07620	COG0573	inorganic phosphate transmembrane transporter activity
HSZ48_RS07625	COG0581	inorganic phosphate transmembrane transporter activity
HSZ48_RS07630	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HSZ48_RS07635	COG0704	Plays a role in the regulation of phosphate uptake
HSZ48_RS07640	COG1164	Oligoendopeptidase f
HSZ48_RS07660	COG2348	transferase activity, transferring amino-acyl groups
HSZ48_RS07665	COG2348	transferase activity, transferring amino-acyl groups
HSZ48_RS07675	COG0159	tryptophan synthase activity
HSZ48_RS07680	COG0133	tryptophan synthase activity
HSZ48_RS07685	COG0135	phosphoribosylanthranilate isomerase activity
HSZ48_RS07690	COG0134	indole-3-glycerol-phosphate synthase activity
HSZ48_RS07695	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HSZ48_RS07700	COG0512	Glutamine amidotransferase of anthranilate synthase
HSZ48_RS07705	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HSZ48_RS07715	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HSZ48_RS07720	COG1363	Peptidase, m42
HSZ48_RS07735	COG0287	Prephenate dehydrogenase
HSZ48_RS07740	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HSZ48_RS07745	COG1942	4-Oxalocrotonate Tautomerase
HSZ48_RS07760	COG1879	ABC-type sugar transport system periplasmic component
HSZ48_RS07765	COG1172	Belongs to the binding-protein-dependent transport system permease family
HSZ48_RS07770	COG1129	ABC transporter
HSZ48_RS07775	COG1869	D-ribose catabolic process
HSZ48_RS07780	COG1609	Transcriptional regulator
HSZ48_RS07785	COG0392	lysyltransferase activity
HSZ48_RS07785	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HSZ48_RS07790	COG0628	permease
HSZ48_RS07805	COG3711	transcriptional antiterminator
HSZ48_RS07810	COG1115	amino acid carrier protein
HSZ48_RS07815	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HSZ48_RS07825	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HSZ48_RS07830	COG4841	protein insertion into membrane
HSZ48_RS07835	COG0824	Thioesterase
HSZ48_RS07840	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HSZ48_RS07845	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HSZ48_RS07850	COG1970	mechanosensitive ion channel activity
HSZ48_RS07855	COG0419	ATPase involved in DNA repair
HSZ48_RS07860	COG0420	3'-5' exonuclease activity
HSZ48_RS07865	COG4846	Membrane protein involved in cytochrome C biogenesis
HSZ48_RS07875	COG3763	UPF0154 protein
HSZ48_RS07895	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HSZ48_RS07905	COG0516	GMP reductase activity
HSZ48_RS07910	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HSZ48_RS07915	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HSZ48_RS07920	COG0753	catalase activity
HSZ48_RS07925	COG0833	amino acid
HSZ48_RS07935	COG0561	phosphatase activity
HSZ48_RS07940	COG0083	homoserine kinase activity
HSZ48_RS07945	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HSZ48_RS07950	COG0460	homoserine dehydrogenase
HSZ48_RS07955	COG0527	aspartate kinase activity
HSZ48_RS07985	COG2197	response regulator
HSZ48_RS07990	COG4585	Histidine kinase
HSZ48_RS07990	COG2203	Gaf domain
HSZ48_RS07995	COG0842	Transport permease protein
HSZ48_RS08000	COG1131	(ABC) transporter
HSZ48_RS08010	COG0174	glutamine synthetase
HSZ48_RS08015	COG0789	Transcriptional regulator
HSZ48_RS08020	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HSZ48_RS08025	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HSZ48_RS08030	COG0386	Belongs to the glutathione peroxidase family
HSZ48_RS08035	COG1923	regulation of RNA biosynthetic process
HSZ48_RS08040	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HSZ48_RS08050	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HSZ48_RS08055	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HSZ48_RS08060	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HSZ48_RS08075	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HSZ48_RS08080	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HSZ48_RS08090	COG4550	Control of competence regulator ComK, YlbF/YmcA
HSZ48_RS08095	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HSZ48_RS08120	COG1013	pyruvate-flavodoxin oxidoreductase activity
HSZ48_RS08125	COG0674	pyruvate-flavodoxin oxidoreductase activity
HSZ48_RS08125	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HSZ48_RS08130	COG1692	metallophosphoesterase
HSZ48_RS08140	COG1418	mRNA catabolic process
HSZ48_RS08145	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HSZ48_RS08150	COG1546	Belongs to the CinA family
HSZ48_RS08150	COG1058	Belongs to the CinA family
HSZ48_RS08170	COG0300	oxidoreductase activity
HSZ48_RS08175	COG0612	Peptidase, M16
HSZ48_RS08180	COG0612	Peptidase, M16
HSZ48_RS08185	COG2188	Transcriptional regulator
HSZ48_RS08190	COG1674	ftsk spoiiie
HSZ48_RS08195	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HSZ48_RS08200	COG1185	polyribonucleotide nucleotidyltransferase activity
HSZ48_RS08205	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HSZ48_RS08210	COG0196	riboflavin kinase activity
HSZ48_RS08215	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HSZ48_RS08220	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HSZ48_RS08235	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HSZ48_RS08240	COG1358	cellular component organization or biogenesis
HSZ48_RS08245	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HSZ48_RS08250	COG0195	Participates in both transcription termination and antitermination
HSZ48_RS08255	COG0779	Required for maturation of 30S ribosomal subunits
HSZ48_RS08260	COG2176	DNA-directed DNA polymerase activity
HSZ48_RS08265	COG0442	prolyl-tRNA aminoacylation
HSZ48_RS08275	COG4589	Belongs to the CDS family
HSZ48_RS08280	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HSZ48_RS08285	COG0233	cytoplasmic translational termination
HSZ48_RS08290	COG0528	UMP kinase activity
HSZ48_RS08295	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HSZ48_RS08300	COG0052	Belongs to the universal ribosomal protein uS2 family
HSZ48_RS08305	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HSZ48_RS08310	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HSZ48_RS08315	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HSZ48_RS08320	COG4974	Belongs to the 'phage' integrase family
HSZ48_RS08325	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HSZ48_RS08330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HSZ48_RS08335	COG0758	DNA mediated transformation
HSZ48_RS08345	COG0045	succinate-CoA ligase (ADP-forming) activity
HSZ48_RS08350	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HSZ48_RS08360	COG4485	Bacterial membrane protein, YfhO
HSZ48_RS08370	COG0335	large ribosomal subunit rRNA binding
HSZ48_RS08375	COG0336	Belongs to the RNA methyltransferase TrmD family
HSZ48_RS08380	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HSZ48_RS08385	COG0228	four-way junction DNA binding
HSZ48_RS08390	COG1028	Short-chain dehydrogenase reductase Sdr
HSZ48_RS08395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HSZ48_RS08400	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HSZ48_RS08405	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HSZ48_RS08410	COG0552	protein localization to endoplasmic reticulum
HSZ48_RS08415	COG1196	nuclear chromosome segregation
HSZ48_RS08420	COG0571	ribonuclease III activity
HSZ48_RS08425	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HSZ48_RS08440	COG0416	fatty acid biosynthetic process
HSZ48_RS08445	COG1349	DNA-binding transcription factor activity
HSZ48_RS08455	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HSZ48_RS08460	COG1760	l-serine dehydratase
HSZ48_RS08465	COG1760	l-serine dehydratase
HSZ48_RS08470	COG1461	Dihydroxyacetone kinase
HSZ48_RS08475	COG1302	Protein conserved in bacteria
HSZ48_RS08480	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HSZ48_RS08485	COG1564	THIamine pyrophosphokinase
HSZ48_RS08490	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HSZ48_RS08495	COG1162	GTPase activity
HSZ48_RS08505	COG0631	protein serine/threonine phosphatase activity
HSZ48_RS08510	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HSZ48_RS08515	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HSZ48_RS08515	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HSZ48_RS08520	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HSZ48_RS08525	COG0242	peptide deformylase activity
HSZ48_RS08540	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HSZ48_RS08545	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HSZ48_RS08550	COG1758	RNA polymerase activity
HSZ48_RS08555	COG0194	GDP metabolic process
HSZ48_RS08560	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HSZ48_RS08570	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HSZ48_RS08580	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HSZ48_RS08585	COG0284	orotidine-5'-phosphate decarboxylase activity
HSZ48_RS08590	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HSZ48_RS08595	COG0505	Belongs to the CarA family
HSZ48_RS08605	COG0540	Belongs to the ATCase OTCase family
HSZ48_RS08615	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HSZ48_RS08620	COG0564	pseudouridine synthase activity
HSZ48_RS08625	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HSZ48_RS08635	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HSZ48_RS08640	COG3599	regulation of cell shape
HSZ48_RS08650	COG0762	integral membrane protein
HSZ48_RS08655	COG1799	cell septum assembly
HSZ48_RS08660	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HSZ48_RS08670	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HSZ48_RS08675	COG0849	cell division
HSZ48_RS08680	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HSZ48_RS08685	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HSZ48_RS08690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HSZ48_RS08700	COG4839	cell division protein FtsL
HSZ48_RS08705	COG0275	rRNA processing
HSZ48_RS08710	COG2001	Belongs to the MraZ family
HSZ48_RS08715	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HSZ48_RS08720	COG0454	-acetyltransferase
HSZ48_RS08725	COG1011	Hydrolase
HSZ48_RS08765	COG2801	Transposase and inactivated derivatives
HSZ48_RS08790	COG2261	transglycosylase associated protein
HSZ48_RS08810	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HSZ48_RS08815	COG2022	thiamine diphosphate biosynthetic process
HSZ48_RS08825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HSZ48_RS08835	COG1070	Carbohydrate kinase
HSZ48_RS08860	COG0210	DNA helicase
HSZ48_RS08865	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HSZ48_RS08885	COG0438	transferase activity, transferring glycosyl groups
HSZ48_RS08890	COG0653	protein targeting
HSZ48_RS08900	COG1073	alpha beta
HSZ48_RS08910	COG0201	protein transport
HSZ48_RS08915	COG3391	amine dehydrogenase activity
HSZ48_RS08925	COG0582	viral genome integration into host DNA
HSZ48_RS08945	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HSZ48_RS08950	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HSZ48_RS08955	COG1053	succinate dehydrogenase
HSZ48_RS08960	COG2009	succinate dehydrogenase
HSZ48_RS08965	COG0322	excinuclease ABC activity
HSZ48_RS08970	COG3118	belongs to the thioredoxin family
HSZ48_RS08975	COG1193	negative regulation of DNA recombination
HSZ48_RS08980	COG1796	DNA polymerase
HSZ48_RS08980	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HSZ48_RS08990	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HSZ48_RS08995	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HSZ48_RS09000	COG0072	phenylalanine-tRNA ligase activity
HSZ48_RS09005	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HSZ48_RS09010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HSZ48_RS09020	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HSZ48_RS09030	COG1323	Belongs to the UPF0348 family
HSZ48_RS09035	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HSZ48_RS09040	COG0742	ribosomal rna small subunit methyltransferase
HSZ48_RS09055	COG0584	glycerophosphoryl diester phosphodiesterase
HSZ48_RS09060	COG3679	Belongs to the UPF0342 family
HSZ48_RS09080	COG0109	protoheme IX farnesyltransferase activity
HSZ48_RS09085	COG1612	heme a metabolic process
HSZ48_RS09095	COG0772	Belongs to the SEDS family
HSZ48_RS09100	COG4838	Belongs to the UPF0358 family
HSZ48_RS09105	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HSZ48_RS09110	COG4896	Protein conserved in bacteria
HSZ48_RS09125	COG0483	inositol monophosphate 1-phosphatase activity
HSZ48_RS09130	COG4493	Belongs to the UPF0637 family
HSZ48_RS09140	COG1914	H( )-stimulated, divalent metal cation uptake system
HSZ48_RS09155	COG1177	transmembrane transport
HSZ48_RS09160	COG1176	ABC-type spermidine putrescine transport system, permease component I
HSZ48_RS09165	COG3842	ATPase activity
HSZ48_RS09175	COG4476	Belongs to the UPF0223 family
HSZ48_RS09220	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HSZ48_RS09225	COG0569	domain protein
HSZ48_RS09230	COG1294	oxidase, subunit
HSZ48_RS09235	COG1271	oxidase subunit
HSZ48_RS09250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HSZ48_RS09260	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HSZ48_RS09275	COG4172	Belongs to the ABC transporter superfamily
HSZ48_RS09280	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HSZ48_RS09285	COG0151	Belongs to the GarS family
HSZ48_RS09290	COG0138	bifunctional purine biosynthesis protein purh
HSZ48_RS09300	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HSZ48_RS09310	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HSZ48_RS09315	COG0047	phosphoribosylformylglycinamidine synthase activity
HSZ48_RS09320	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HSZ48_RS09325	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HSZ48_RS09330	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HSZ48_RS09335	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HSZ48_RS09340	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HSZ48_RS09345	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HSZ48_RS09345	COG1017	nitric oxide dioxygenase activity
HSZ48_RS09355	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HSZ48_RS09360	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HSZ48_RS09365	COG1845	cytochrome c oxidase, subunit III
HSZ48_RS09370	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HSZ48_RS09380	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HSZ48_RS09385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HSZ48_RS09390	COG1316	TRANSCRIPTIONal
HSZ48_RS09415	COG3594	Acyltransferase
HSZ48_RS09420	COG0436	Aminotransferase
HSZ48_RS09430	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HSZ48_RS09440	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HSZ48_RS09445	COG1169	isochorismate synthase
HSZ48_RS09450	COG1575	Belongs to the MenA family. Type 1 subfamily
HSZ48_RS09460	COG2314	TM2 domain
HSZ48_RS09465	COG1764	response to oxidative stress
HSZ48_RS09480	COG4903	ComK protein
HSZ48_RS09495	COG4873	Protein conserved in bacteria
HSZ48_RS09505	COG0737	Belongs to the 5'-nucleotidase family
HSZ48_RS09510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HSZ48_RS09515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HSZ48_RS09520	COG0861	Integral membrane protein TerC family
HSZ48_RS09525	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HSZ48_RS09535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HSZ48_RS09540	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HSZ48_RS09545	COG2814	Major facilitator Superfamily
HSZ48_RS09550	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HSZ48_RS09560	COG1115	amino acid carrier protein
HSZ48_RS09565	COG0628	permease
HSZ48_RS09575	COG0475	glutathione-regulated potassium exporter activity
HSZ48_RS09575	COG0569	domain protein
HSZ48_RS09580	COG2239	Acts as a magnesium transporter
HSZ48_RS09585	COG0564	pseudouridine synthase activity
HSZ48_RS09590	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HSZ48_RS09595	COG2357	RelA SpoT domain protein
HSZ48_RS09605	COG4116	CYTH
HSZ48_RS09610	COG2346	COG2346, Truncated hemoglobins
HSZ48_RS09620	COG2910	NAD(P)H-binding
HSZ48_RS09625	COG1164	Oligoendopeptidase f
HSZ48_RS09635	COG4862	establishment of competence for transformation
HSZ48_RS09640	COG1393	Belongs to the ArsC family
HSZ48_RS09645	COG0180	Tryptophanyl-tRNA synthetase
HSZ48_RS09650	COG4166	transmembrane transport
HSZ48_RS09655	COG4608	Belongs to the ABC transporter superfamily
HSZ48_RS09660	COG0444	Belongs to the ABC transporter superfamily
HSZ48_RS09665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HSZ48_RS09690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HSZ48_RS09700	COG0542	response to heat
HSZ48_RS09715	COG0561	phosphatase activity
HSZ48_RS09720	COG0446	pyridine nucleotide-disulphide oxidoreductase
HSZ48_RS09730	COG0179	Fumarylacetoacetate (FAA) hydrolase
HSZ48_RS09735	COG2311	Membrane
HSZ48_RS09740	COG1074	ATP-dependent DNA helicase activity
HSZ48_RS09745	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HSZ48_RS09760	COG0398	Pfam SNARE associated Golgi protein
HSZ48_RS09765	COG0166	Belongs to the GPI family
HSZ48_RS09770	COG0137	argininosuccinate synthase activity
HSZ48_RS09775	COG0165	Argininosuccinate lyase
HSZ48_RS09780	COG0584	glycerophosphoryl diester phosphodiesterase
HSZ48_RS09790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HSZ48_RS09795	COG1902	pentaerythritol trinitrate reductase activity
HSZ48_RS09800	COG1098	S1 RNA binding domain
HSZ48_RS09805	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HSZ48_RS09815	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HSZ48_RS09815	COG2111	Na H antiporter
HSZ48_RS09820	COG2111	Na H antiporter
HSZ48_RS09825	COG1006	Multisubunit Na H antiporter MnhC subunit
HSZ48_RS09830	COG0651	ATP synthesis coupled electron transport
HSZ48_RS09835	COG1863	multisubunit Na H antiporter MnhE subunit
HSZ48_RS09840	COG2212	antiporter activity
HSZ48_RS09845	COG1320	monovalent cation:proton antiporter activity
HSZ48_RS09855	COG2050	protein possibly involved in aromatic compounds catabolism
HSZ48_RS09860	COG2056	Na+-H+ antiporter family
HSZ48_RS09865	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HSZ48_RS09870	COG1252	NADH dehydrogenase
HSZ48_RS09875	COG0316	Belongs to the HesB IscA family
HSZ48_RS09880	COG4844	belongs to the
HSZ48_RS09885	COG1252	NADH dehydrogenase
HSZ48_RS09890	COG4837	Protein of unknown function (DUF1462)
HSZ48_RS09895	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HSZ48_RS09900	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HSZ48_RS09905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HSZ48_RS09910	COG1696	Membrane protein involved in D-alanine export
HSZ48_RS09915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HSZ48_RS09930	COG0647	UMP catabolic process
HSZ48_RS09935	COG2445	Protein of unknown function DUF86
HSZ48_RS09945	COG4470	Protein conserved in bacteria
HSZ48_RS09950	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HSZ48_RS09955	COG0737	Belongs to the 5'-nucleotidase family
HSZ48_RS09960	COG0730	response to heat
HSZ48_RS09965	COG1801	Protein of unknown function DUF72
HSZ48_RS09970	COG2070	2-Nitropropane dioxygenase
HSZ48_RS09975	COG1253	flavin adenine dinucleotide binding
HSZ48_RS09985	COG0719	Fe-S assembly protein
HSZ48_RS09990	COG0822	iron-sulfur transferase activity
HSZ48_RS09995	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HSZ48_RS10000	COG0719	Fe-S assembly protein
HSZ48_RS10005	COG0396	ATPase activity
HSZ48_RS10015	COG1253	flavin adenine dinucleotide binding
HSZ48_RS10025	COG1464	Belongs to the NlpA lipoprotein family
HSZ48_RS10030	COG2011	ABC-type metal ion transport system permease component
HSZ48_RS10035	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HSZ48_RS10040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HSZ48_RS10045	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HSZ48_RS10050	COG0509	glycine decarboxylation via glycine cleavage system
HSZ48_RS10055	COG1393	Belongs to the ArsC family
HSZ48_RS10060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HSZ48_RS10065	COG0778	Nitroreductase
HSZ48_RS10070	COG0710	3-dehydroquinate dehydratase activity
HSZ48_RS10075	COG1764	response to oxidative stress
HSZ48_RS10090	COG2851	Citrate transporter
HSZ48_RS10105	COG2314	TM2 domain
HSZ48_RS10205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HSZ48_RS10210	COG0546	phosphoglycolate phosphatase activity
HSZ48_RS10225	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HSZ48_RS10230	COG0557	exoribonuclease II activity
HSZ48_RS10235	COG1647	Serine aminopeptidase, S33
HSZ48_RS10240	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HSZ48_RS10250	COG0148	phosphopyruvate hydratase activity
HSZ48_RS10255	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HSZ48_RS10260	COG0149	triose-phosphate isomerase activity
HSZ48_RS10265	COG0126	phosphoglycerate kinase activity
HSZ48_RS10295	COG1090	epimerase
HSZ48_RS10305	COG0740	serine-type endopeptidase activity
HSZ48_RS10325	COG0346	lactoylglutathione lyase activity
HSZ48_RS10435	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HSZ48_RS10440	COG1481	regulation of sporulation
HSZ48_RS10445	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HSZ48_RS10450	COG1660	Displays ATPase and GTPase activities
HSZ48_RS10455	COG0492	ferredoxin-NADP+ reductase activity
HSZ48_RS10465	COG0110	maltose O-acetyltransferase activity
HSZ48_RS10470	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HSZ48_RS10475	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HSZ48_RS10485	COG0556	nucleotide-excision repair
HSZ48_RS10500	COG1388	LysM domain
HSZ48_RS10500	COG3942	CHAP domain
HSZ48_RS10510	COG0653	protein targeting
HSZ48_RS10515	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HSZ48_RS10525	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HSZ48_RS10535	COG1739	Uncharacterized protein family UPF0029
HSZ48_RS10540	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HSZ48_RS10545	COG2199	diguanylate cyclase activity
HSZ48_RS10560	COG2195	Cleaves the N-terminal amino acid of tripeptides
HSZ48_RS10565	COG1929	Belongs to the glycerate kinase type-1 family
HSZ48_RS10585	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HSZ48_RS10600	COG4607	ABC-type enterochelin transport system periplasmic component
HSZ48_RS10605	COG4604	ABC transporter, ATP-binding protein
HSZ48_RS10610	COG4605	iron ion homeostasis
HSZ48_RS10615	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HSZ48_RS10620	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HSZ48_RS10625	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HSZ48_RS10630	COG1780	Probably involved in ribonucleotide reductase function
HSZ48_RS10640	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HSZ48_RS10645	COG3104	oligopeptide transport
HSZ48_RS10650	COG3104	oligopeptide transport
HSZ48_RS10655	COG1597	lipid kinase activity
HSZ48_RS10665	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HSZ48_RS10670	COG1174	glycine betaine transport
HSZ48_RS10675	COG0517	IMP dehydrogenase activity
HSZ48_RS10675	COG1125	glycine betaine transport
HSZ48_RS10680	COG0514	ATP-dependent DNA helicase (RecQ)
HSZ48_RS10685	COG0488	(ABC) transporter
HSZ48_RS10695	COG1368	sulfuric ester hydrolase activity
HSZ48_RS10705	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HSZ48_RS10715	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HSZ48_RS10720	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HSZ48_RS10720	COG0512	Glutamine amidotransferase of anthranilate synthase
HSZ48_RS10725	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HSZ48_RS10730	COG0720	synthase
HSZ48_RS10735	COG0602	queuosine metabolic process
HSZ48_RS10750	COG0463	Glycosyl transferase, family 2
HSZ48_RS10755	COG0656	L-ascorbic acid biosynthetic process
HSZ48_RS10760	COG1253	flavin adenine dinucleotide binding
HSZ48_RS10765	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HSZ48_RS10770	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HSZ48_RS10770	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HSZ48_RS10770	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HSZ48_RS10775	COG1105	Belongs to the carbohydrate kinase PfkB family
HSZ48_RS10780	COG1349	DNA-binding transcription factor activity
HSZ48_RS10785	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HSZ48_RS10790	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HSZ48_RS10815	COG0039	L-malate dehydrogenase activity
HSZ48_RS10820	COG0586	Pfam SNARE associated Golgi protein
HSZ48_RS10830	COG4989	oxidoreductase activity
HSZ48_RS10845	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HSZ48_RS10850	COG4988	ABC transporter
HSZ48_RS10855	COG1968	undecaprenyl-diphosphatase activity
HSZ48_RS10865	COG1671	Belongs to the UPF0178 family
HSZ48_RS10870	COG1611	Belongs to the LOG family
HSZ48_RS10875	COG1279	arginine transmembrane transporter activity
HSZ48_RS10880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HSZ48_RS10910	COG2814	Major facilitator Superfamily
HSZ48_RS10915	COG2839	Protein conserved in bacteria
HSZ48_RS10920	COG2814	Major facilitator Superfamily
HSZ48_RS10925	COG0583	DNA-binding transcription factor activity
HSZ48_RS10935	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HSZ48_RS10945	COG0217	transcriptional regulatory protein
HSZ48_RS10965	COG3942	CHAP domain
HSZ48_RS10965	COG1388	LysM domain
HSZ48_RS10970	COG0306	phosphate transporter
HSZ48_RS10975	COG1392	Phosphate transport regulator
HSZ48_RS10980	COG2205	protein histidine kinase activity
HSZ48_RS10990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HSZ48_RS11005	COG3949	Membrane
HSZ48_RS11015	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HSZ48_RS11020	COG1461	Dihydroxyacetone kinase
HSZ48_RS11025	COG2376	Dihydroxyacetone kinase
HSZ48_RS11030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HSZ48_RS11035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HSZ48_RS11040	COG1120	ATPase activity
HSZ48_RS11045	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HSZ48_RS11050	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HSZ48_RS11055	COG1132	(ABC) transporter
HSZ48_RS11065	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HSZ48_RS11070	COG1216	Glycosyl transferase, family 2
HSZ48_RS11070	COG1442	glycosyl transferase family 8
HSZ48_RS11075	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HSZ48_RS11080	COG1682	transport, permease protein
HSZ48_RS11085	COG1134	teichoic acid transport
HSZ48_RS11090	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HSZ48_RS11105	COG1121	(ABC) transporter
HSZ48_RS11110	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HSZ48_RS11115	COG0803	Belongs to the bacterial solute-binding protein 9 family
HSZ48_RS11125	COG1320	monovalent cation:proton antiporter activity
HSZ48_RS11130	COG2212	antiporter activity
HSZ48_RS11135	COG1863	multisubunit Na H antiporter MnhE subunit
HSZ48_RS11140	COG0651	ATP synthesis coupled electron transport
HSZ48_RS11145	COG1006	Multisubunit Na H antiporter MnhC subunit
HSZ48_RS11150	COG2111	Na H antiporter
HSZ48_RS11155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HSZ48_RS11155	COG2111	Na H antiporter
HSZ48_RS11190	COG0596	Alpha beta hydrolase
HSZ48_RS11205	COG2267	carboxylic ester hydrolase activity
HSZ48_RS11210	COG0546	phosphoglycolate phosphatase activity
HSZ48_RS11215	COG4139	cobalamin transport
HSZ48_RS11220	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HSZ48_RS11225	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HSZ48_RS11230	COG0018	arginyl-trna synthetase
HSZ48_RS11245	COG1078	dGTPase activity
HSZ48_RS11250	COG0456	acetyltransferase
HSZ48_RS11260	COG0667	Aldo Keto reductase
HSZ48_RS11265	COG4844	belongs to the
HSZ48_RS11285	COG0095	Lipoate-protein ligase
HSZ48_RS11290	COG0280	phosphate acetyltransferase
HSZ48_RS11315	COG1846	Transcriptional regulator
HSZ48_RS11325	COG2363	Small membrane protein
HSZ48_RS11335	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HSZ48_RS11340	COG0351	phosphomethylpyrimidine kinase
HSZ48_RS11360	COG0534	Mate efflux family protein
HSZ48_RS11385	COG0183	Belongs to the thiolase family
HSZ48_RS11390	COG0318	PFAM AMP-dependent synthetase and ligase
HSZ48_RS11400	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HSZ48_RS11405	COG0363	glucosamine-6-phosphate deaminase activity
HSZ48_RS11415	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HSZ48_RS11420	COG1469	GTP cyclohydrolase I activity
HSZ48_RS11425	COG1846	Transcriptional regulator
HSZ48_RS11430	COG0431	NADPH-dependent FMN reductase
HSZ48_RS11435	COG0561	phosphatase activity
HSZ48_RS11445	COG1428	Deoxynucleoside kinase
HSZ48_RS11450	COG1428	Deoxynucleoside kinase
HSZ48_RS11460	COG0546	phosphoglycolate phosphatase activity
HSZ48_RS11480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HSZ48_RS11500	COG2824	Alkylphosphonate utilization operon protein PhnA
HSZ48_RS11510	COG1113	amino acid transport
HSZ48_RS11515	COG2040	homocysteine
HSZ48_RS11520	COG0833	amino acid
HSZ48_RS11530	COG0010	Belongs to the arginase family
HSZ48_RS11535	COG1914	H( )-stimulated, divalent metal cation uptake system
HSZ48_RS11545	COG1069	ribulokinase activity
HSZ48_RS11550	COG1063	alcohol dehydrogenase
HSZ48_RS11555	COG2814	Major facilitator Superfamily
HSZ48_RS11560	COG1349	DNA-binding transcription factor activity
HSZ48_RS11585	COG0583	DNA-binding transcription factor activity
HSZ48_RS11610	COG0667	Aldo Keto reductase
HSZ48_RS11620	COG3477	response to acidic pH
HSZ48_RS11635	COG1682	transport, permease protein
HSZ48_RS11650	COG1028	Short-chain dehydrogenase reductase Sdr
HSZ48_RS11655	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HSZ48_RS11660	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HSZ48_RS11665	COG1316	TRANSCRIPTIONal
HSZ48_RS11675	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HSZ48_RS11760	COG1473	amidohydrolase
HSZ48_RS11765	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HSZ48_RS11770	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HSZ48_RS11775	COG0049	tRNA binding
HSZ48_RS11780	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HSZ48_RS11790	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HSZ48_RS11795	COG0085	RNA polymerase activity
HSZ48_RS11800	COG2813	Specifically methylates the guanine in position
HSZ48_RS11805	COG0222	ribosome binding
HSZ48_RS11810	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HSZ48_RS11815	COG0081	regulation of translation
HSZ48_RS11820	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HSZ48_RS11825	COG0250	Participates in transcription elongation, termination and antitermination
HSZ48_RS11835	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HSZ48_RS11850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HSZ48_RS11855	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HSZ48_RS11860	COG0215	cysteine-tRNA ligase activity
HSZ48_RS11865	COG1045	serine acetyltransferase
HSZ48_RS11870	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HSZ48_RS11875	COG4956	integral membrane protein (PIN domain superfamily)
HSZ48_RS11880	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HSZ48_RS11885	COG0542	response to heat
HSZ48_RS11890	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HSZ48_RS11895	COG3880	PFAM UvrB UvrC protein
HSZ48_RS11900	COG4463	regulation of RNA biosynthetic process
HSZ48_RS11905	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HSZ48_RS11910	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HSZ48_RS11915	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HSZ48_RS11920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HSZ48_RS12005	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HSZ48_RS12010	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HSZ48_RS12030	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HSZ48_RS12035	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HSZ48_RS12050	COG1098	S1 RNA binding domain
HSZ48_RS12060	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HSZ48_RS12065	COG3956	TIGRFAM MazG family protein
HSZ48_RS12070	COG2244	polysaccharide biosynthetic process
HSZ48_RS12075	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HSZ48_RS12080	COG0193	aminoacyl-tRNA hydrolase activity
HSZ48_RS12085	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HSZ48_RS12090	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HSZ48_RS12095	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HSZ48_RS12100	COG2088	sporulation resulting in formation of a cellular spore
HSZ48_RS12105	COG0251	oxidation-reduction process
HSZ48_RS12110	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HSZ48_RS12115	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HSZ48_RS12120	COG4466	Protein conserved in bacteria
HSZ48_RS12125	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HSZ48_RS12130	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HSZ48_RS12135	COG0084	hydrolase, TatD family'
HSZ48_RS12140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HSZ48_RS12140	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HSZ48_RS12145	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HSZ48_RS12150	COG2827	Endonuclease containing a URI domain
HSZ48_RS12155	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HSZ48_RS12160	COG4467	Involved in initiation control of chromosome replication
HSZ48_RS12165	COG1774	PSP1 C-terminal conserved region
HSZ48_RS12170	COG0470	DNA polymerase III
HSZ48_RS12175	COG3870	Protein conserved in bacteria
HSZ48_RS12180	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HSZ48_RS12185	COG1982	Orn Lys Arg decarboxylase major
HSZ48_RS12205	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HSZ48_RS12210	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HSZ48_RS12215	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HSZ48_RS12230	COG2188	Transcriptional regulator
HSZ48_RS12235	COG0366	Alpha amylase catalytic
HSZ48_RS12240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HSZ48_RS12240	COG1263	PTS System
HSZ48_RS12250	COG0493	'glutamate synthase
HSZ48_RS12255	COG0067	glutamate synthase
HSZ48_RS12255	COG0069	glutamate synthase activity
HSZ48_RS12255	COG0070	glutamate synthase
HSZ48_RS12260	COG0583	DNA-binding transcription factor activity
HSZ48_RS12275	COG0004	ammonium transporteR
HSZ48_RS12280	COG0494	nUDIX hydrolase
HSZ48_RS12290	COG3942	CHAP domain
HSZ48_RS12290	COG1388	LysM domain
HSZ48_RS12300	COG0129	dihydroxy-acid dehydratase activity
HSZ48_RS12315	COG0733	neurotransmitter:sodium symporter activity
HSZ48_RS12320	COG1114	Component of the transport system for branched-chain amino acids
HSZ48_RS12325	COG5646	InterPro IPR014922
HSZ48_RS12340	COG4195	phage-related replication protein
HSZ48_RS12345	COG2807	transmembrane transport
HSZ48_RS12350	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HSZ48_RS12350	COG0456	acetyltransferase
HSZ48_RS12355	COG2814	Major facilitator Superfamily
HSZ48_RS12365	COG2814	Major facilitator Superfamily
HSZ48_RS12415	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HSZ48_RS12415	COG0519	Catalyzes the synthesis of GMP from XMP
HSZ48_RS12420	COG0516	GMP reductase activity
HSZ48_RS12420	COG0517	IMP dehydrogenase activity
HSZ48_RS12425	COG2233	PERMEase
HSZ48_RS12430	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HSZ48_RS12450	COG1823	symporter activity
HSZ48_RS12460	COG0778	Nitroreductase
HSZ48_RS12465	COG3620	sequence-specific DNA binding
HSZ48_RS12470	COG0450	alkyl hydroperoxide reductase
HSZ48_RS12475	COG3634	alkyl hydroperoxide reductase activity
HSZ48_RS12510	COG1280	lysine exporter protein (LysE YggA)
HSZ48_RS12520	COG2076	Multidrug Resistance protein
HSZ48_RS12540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HSZ48_RS12560	COG4195	phage-related replication protein
HSZ48_RS12565	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HSZ48_RS12575	COG1522	sequence-specific DNA binding
HSZ48_RS12590	COG2808	Putative FMN-binding domain
HSZ48_RS12630	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HSZ48_RS12640	COG0360	Binds together with S18 to 16S ribosomal RNA
HSZ48_RS12650	COG0012	GTP binding
HSZ48_RS12655	COG4481	Protein conserved in bacteria
HSZ48_RS12660	COG0668	transmembrane transport
HSZ48_RS12665	COG5609	conserved protein (DUF2294)
HSZ48_RS12670	COG3002	Belongs to the UPF0753 family
HSZ48_RS12675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HSZ48_RS12690	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HSZ48_RS12720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HSZ48_RS12725	COG2814	Major facilitator Superfamily
HSZ48_RS12755	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HSZ48_RS12765	COG0529	Catalyzes the synthesis of activated sulfate
HSZ48_RS12770	COG2046	Belongs to the sulfate adenylyltransferase family
HSZ48_RS12775	COG0730	response to heat
HSZ48_RS12795	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HSZ48_RS12800	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HSZ48_RS12805	COG0175	sulfate reduction
HSZ48_RS12820	COG1475	DNA binding
HSZ48_RS12825	COG0626	cystathionine gamma-synthase activity
HSZ48_RS12830	COG0626	cystathionine gamma-synthase activity
HSZ48_RS12835	COG0646	methionine synthase
HSZ48_RS12835	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HSZ48_RS12840	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HSZ48_RS12850	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HSZ48_RS12875	COG0183	Belongs to the thiolase family
HSZ48_RS12885	COG1960	acyl-CoA dehydrogenase activity
HSZ48_RS12890	COG0318	PFAM AMP-dependent synthetase and ligase
HSZ48_RS12900	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HSZ48_RS12910	COG0561	phosphatase activity
HSZ48_RS12915	COG0531	amino acid
HSZ48_RS12920	COG0656	L-ascorbic acid biosynthetic process
HSZ48_RS12960	COG1966	Carbon starvation protein
HSZ48_RS12965	COG1475	DNA binding
HSZ48_RS12970	COG0357	Ribosomal RNA small subunit methyltransferase G
HSZ48_RS12975	COG0445	tRNA wobble uridine modification
HSZ48_RS12980	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HSZ48_RS12985	COG0594	ribonuclease P activity
HSZ48_RS13010	COG2124	cytochrome p450
HSZ48_RS13065	COG0758	DNA mediated transformation
HSZ48_RS13115	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HSZ48_RS13135	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HSZ48_RS13140	COG1845	cytochrome c oxidase, subunit III
HSZ48_RS13145	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HSZ48_RS13150	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HSZ48_RS13180	COG4297	protein containing double-stranded beta helix domain
HSZ48_RS13195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HSZ48_RS13240	COG1192	Involved in chromosome partitioning
HSZ48_RS13365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HSZ48_RS13365	COG0551	DNA topoisomerase type I activity
HSZ48_RS13380	COG0551	DNA topoisomerase type I activity
HSZ48_RS13390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HSZ48_RS13395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HSZ48_RS13540	COG2348	transferase activity, transferring amino-acyl groups