locus-tag	class	description
SSP_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
SSP_RS00010	COG0592	DNA-directed DNA polymerase activity
SSP_RS00015	COG2501	S4 domain
SSP_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SSP_RS00025	COG0187	DNA topoisomerase II activity
SSP_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SSP_RS00040	COG2986	histidine ammonia-lyase
SSP_RS00045	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SSP_RS00050	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
SSP_RS00060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
SSP_RS00070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
SSP_RS00075	COG0359	binds to the 23S rRNA
SSP_RS00080	COG0305	Participates in initiation and elongation during chromosome replication
SSP_RS00085	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
SSP_RS00090	COG1819	glycosyl
SSP_RS00110	COG0477	Major facilitator Superfamily
SSP_RS00115	COG0745	RESPONSE REGULATOR receiver
SSP_RS00120	COG5002	protein histidine kinase activity
SSP_RS00125	COG4863	YycH protein
SSP_RS00135	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
SSP_RS00140	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
SSP_RS00275	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SSP_RS00300	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SSP_RS00325	COG1215	transferase activity, transferring glycosyl groups
SSP_RS00360	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
SSP_RS00410	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SSP_RS00415	COG0579	oxidoreductase
SSP_RS00420	COG0028	Belongs to the TPP enzyme family
SSP_RS00425	COG3527	Alpha-acetolactate decarboxylase
SSP_RS00430	COG1620	l-lactate permease
SSP_RS00435	COG0583	DNA-binding transcription factor activity
SSP_RS00450	COG1136	(ABC) transporter
SSP_RS00460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SSP_RS00505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SSP_RS00510	COG1733	regulation of RNA biosynthetic process
SSP_RS00515	COG2207	Transcriptional regulator
SSP_RS00520	COG2211	Major facilitator Superfamily
SSP_RS00525	COG3250	beta-galactosidase activity
SSP_RS00535	COG0463	Glycosyl transferase, family 2
SSP_RS00570	COG1028	Short-chain dehydrogenase reductase Sdr
SSP_RS00580	COG1388	LysM domain
SSP_RS00585	COG1388	LysM domain
SSP_RS00590	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SSP_RS00610	COG1263	PTS System
SSP_RS00610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SSP_RS00610	COG2190	(PTS) system
SSP_RS00625	COG1054	Belongs to the UPF0176 family
SSP_RS00655	COG1131	(ABC) transporter
SSP_RS00665	COG5295	Hep Hag repeat protein
SSP_RS00665	COG4932	domain protein
SSP_RS00675	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SSP_RS00680	COG1511	domain protein
SSP_RS00680	COG1511	domain protein
SSP_RS00705	COG1328	CTP reductase activity
SSP_RS00715	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
SSP_RS00720	COG0346	lactoylglutathione lyase activity
SSP_RS00755	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SSP_RS00760	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
SSP_RS00765	COG0579	oxidoreductase
SSP_RS00805	COG0477	Major facilitator Superfamily
SSP_RS00815	COG2814	Major facilitator Superfamily
SSP_RS00820	COG0583	DNA-binding transcription factor activity
SSP_RS00835	COG0584	glycerophosphoryl diester phosphodiesterase
SSP_RS00845	COG3961	Belongs to the TPP enzyme family
SSP_RS00855	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
SSP_RS00860	COG1691	(AIR) carboxylase
SSP_RS00865	COG1606	tRNA processing
SSP_RS00870	COG3875	lactate racemase activity
SSP_RS00880	COG3835	regulator
SSP_RS00890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SSP_RS00890	COG0574	Belongs to the PEP-utilizing enzyme family
SSP_RS00895	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SSP_RS00905	COG1396	sequence-specific DNA binding
SSP_RS00910	COG2807	transmembrane transport
SSP_RS00920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SSP_RS00925	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SSP_RS00930	COG1012	belongs to the aldehyde dehydrogenase family
SSP_RS00935	COG0531	amino acid
SSP_RS00950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
SSP_RS00960	COG1510	regulation of RNA biosynthetic process
SSP_RS00965	COG1012	belongs to the aldehyde dehydrogenase family
SSP_RS00970	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
SSP_RS00975	COG0583	DNA-binding transcription factor activity
SSP_RS00980	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
SSP_RS00990	COG4221	oxidoreductase activity
SSP_RS01020	COG0778	Nitroreductase
SSP_RS01025	COG2843	Capsule synthesis protein
SSP_RS01030	COG1957	nucleoside hydrolase
SSP_RS01035	COG0477	Major facilitator Superfamily
SSP_RS01055	COG1131	(ABC) transporter
SSP_RS01065	COG0531	amino acid
SSP_RS01070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SSP_RS01075	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
SSP_RS01080	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
SSP_RS01085	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
SSP_RS01100	COG0431	NADPH-dependent FMN reductase
SSP_RS01105	COG3226	Transcriptional regulator
SSP_RS01120	COG1620	l-lactate permease
SSP_RS01125	COG2814	Major facilitator Superfamily
SSP_RS01140	COG1263	PTS System
SSP_RS01140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SSP_RS01140	COG2190	(PTS) system
SSP_RS01160	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SSP_RS01170	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
SSP_RS01175	COG1447	Phosphotransferase system cellobiose-specific component IIA
SSP_RS01180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SSP_RS01185	COG0765	amino acid transport
SSP_RS01190	COG1126	abc transporter atp-binding protein
SSP_RS01200	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SSP_RS01210	COG1464	Belongs to the NlpA lipoprotein family
SSP_RS01215	COG0039	L-malate dehydrogenase activity
SSP_RS01220	COG1940	carbohydrate kinase activity
SSP_RS01230	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SSP_RS01235	COG0626	cystathionine gamma-synthase activity
SSP_RS01260	COG0829	nickel cation binding
SSP_RS01265	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
SSP_RS01270	COG0830	nickel cation binding
SSP_RS01275	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
SSP_RS01280	COG0804	urea catabolic process
SSP_RS01285	COG0832	Belongs to the urease beta subunit family
SSP_RS01290	COG0831	urea catabolic process
SSP_RS01295	COG4413	Urea transporter
SSP_RS01300	COG0747	negative chemotaxis
SSP_RS01325	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SSP_RS01335	COG0531	amino acid
SSP_RS01345	COG0561	phosphatase activity
SSP_RS01355	COG0167	dihydroorotate dehydrogenase activity
SSP_RS01360	COG3001	Fructosamine kinase
SSP_RS01385	COG0697	spore germination
SSP_RS01410	COG3189	MarR family transcriptional regulator
SSP_RS01425	COG0741	lytic transglycosylase activity
SSP_RS01430	COG0436	Aminotransferase
SSP_RS01440	COG2608	mercury ion transmembrane transporter activity
SSP_RS01445	COG2217	Heavy metal translocating P-type atpase
SSP_RS01450	COG0659	secondary active sulfate transmembrane transporter activity
SSP_RS01455	COG1136	(ABC) transporter
SSP_RS01460	COG0577	efflux transmembrane transporter activity
SSP_RS01465	COG1028	Short-chain dehydrogenase reductase Sdr
SSP_RS01480	COG0471	metal ion transport
SSP_RS01485	COG5505	Protein of unknown function (DUF819)
SSP_RS01500	COG4336	lyase activity
SSP_RS01510	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
SSP_RS01515	COG1012	belongs to the aldehyde dehydrogenase family
SSP_RS01525	COG2409	Drug exporters of the RND superfamily
SSP_RS01540	COG1473	amidohydrolase
SSP_RS01565	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
SSP_RS01570	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SSP_RS01575	COG3425	synthase
SSP_RS01590	COG3386	PFAM SMP-30 Gluconolaconase
SSP_RS01595	COG3942	CHAP domain
SSP_RS01600	COG1757	Na H antiporter
SSP_RS01605	COG0583	DNA-binding transcription factor activity
SSP_RS01615	COG1346	cytolysis
SSP_RS01620	COG0028	Belongs to the TPP enzyme family
SSP_RS01625	COG1288	antiporter activity
SSP_RS01630	COG2826	transposase and inactivated derivatives, IS30 family
SSP_RS01635	COG2190	(PTS) system
SSP_RS01635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SSP_RS01635	COG1263	PTS System
SSP_RS01645	COG2515	1-aminocyclopropane-1-carboxylate deaminase
SSP_RS01655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SSP_RS01680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SSP_RS01690	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SSP_RS01700	COG2843	Capsule synthesis protein
SSP_RS01715	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
SSP_RS01720	COG1063	alcohol dehydrogenase
SSP_RS01725	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SSP_RS01745	COG1129	ABC transporter
SSP_RS01780	COG1070	Carbohydrate kinase
SSP_RS01785	COG1063	alcohol dehydrogenase
SSP_RS01810	COG3764	Sortase (surface protein transpeptidase)
SSP_RS01815	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
SSP_RS01820	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SSP_RS01830	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SSP_RS01835	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SSP_RS01840	COG2249	NAD(P)H dehydrogenase (quinone) activity
SSP_RS01845	COG0561	phosphatase activity
SSP_RS01850	COG0778	Nitroreductase
SSP_RS01855	COG2723	6-phospho-beta-galactosidase activity
SSP_RS01860	COG3711	transcriptional antiterminator
SSP_RS01865	COG3711	transcriptional antiterminator
SSP_RS01870	COG2514	catechol 2,3-dioxygenase activity
SSP_RS01880	COG1132	(ABC) transporter
SSP_RS01885	COG1132	(ABC) transporter
SSP_RS01900	COG1012	belongs to the aldehyde dehydrogenase family
SSP_RS01905	COG1846	Transcriptional regulator
SSP_RS01910	COG0346	lactoylglutathione lyase activity
SSP_RS01915	COG0346	lactoylglutathione lyase activity
SSP_RS01920	COG0400	carboxylic ester hydrolase activity
SSP_RS01930	COG0471	metal ion transport
SSP_RS01935	COG3949	Membrane
SSP_RS01945	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
SSP_RS01950	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SSP_RS01955	COG0586	Pfam SNARE associated Golgi protein
SSP_RS01960	COG2271	Major facilitator Superfamily
SSP_RS01970	COG1289	transmembrane transporter activity
SSP_RS01985	COG4876	unkown
SSP_RS01990	COG2357	RelA SpoT domain protein
SSP_RS02000	COG1802	Transcriptional regulator
SSP_RS02010	COG2610	gluconate transmembrane transporter activity
SSP_RS02020	COG3949	Membrane
SSP_RS02040	COG4221	oxidoreductase activity
SSP_RS02065	COG0107	imidazoleglycerol-phosphate synthase activity
SSP_RS02070	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
SSP_RS02075	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
SSP_RS02080	COG0131	Imidazoleglycerol-phosphate dehydratase
SSP_RS02085	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SSP_RS02090	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
SSP_RS02095	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
SSP_RS02100	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
SSP_RS02105	COG3048	D-serine ammonia-lyase activity
SSP_RS02110	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
SSP_RS02115	COG0248	Ppx GppA phosphatase
SSP_RS02120	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
SSP_RS02125	COG1028	Short-chain dehydrogenase reductase Sdr
SSP_RS02130	COG1363	Peptidase, m42
SSP_RS02140	COG0069	glutamate synthase activity
SSP_RS02155	COG4619	ABC transporter
SSP_RS02160	COG0390	transport system, permease component
SSP_RS02165	COG2814	Major facilitator Superfamily
SSP_RS02170	COG0531	amino acid
SSP_RS02185	COG3246	L-lysine catabolic process to acetate
SSP_RS02190	COG1250	3-hydroxyacyl-CoA dehydrogenase
SSP_RS02205	COG1174	glycine betaine transport
SSP_RS02215	COG1174	glycine betaine transport
SSP_RS02225	COG1960	acyl-CoA dehydrogenase activity
SSP_RS02230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
SSP_RS02240	COG1116	anion transmembrane transporter activity
SSP_RS02250	COG1346	cytolysis
SSP_RS02255	COG1380	Effector of murein hydrolase LrgA
SSP_RS02260	COG3279	Response regulator of the LytR AlgR family
SSP_RS02265	COG3275	phosphorelay sensor kinase activity
SSP_RS02275	COG4187	Peptidase family M20/M25/M40
SSP_RS02300	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
SSP_RS02315	COG0025	NhaP-type Na H and K H
SSP_RS02335	COG2814	Major facilitator Superfamily
SSP_RS02345	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
SSP_RS02350	COG1388	LysM domain
SSP_RS02355	COG0588	phosphoglycerate mutase activity
SSP_RS02360	COG2814	Major facilitator Superfamily
SSP_RS02390	COG3443	Belongs to the bacterial solute-binding protein 9 family
SSP_RS02390	COG0803	Belongs to the bacterial solute-binding protein 9 family
SSP_RS02395	COG2353	YceI-like domain
SSP_RS02425	COG2723	6-phospho-beta-galactosidase activity
SSP_RS02430	COG1959	2 iron, 2 sulfur cluster binding
SSP_RS02435	COG2116	formate transmembrane transporter activity
SSP_RS02440	COG0454	-acetyltransferase
SSP_RS02450	COG0071	Belongs to the small heat shock protein (HSP20) family
SSP_RS02460	COG1846	Transcriptional regulator
SSP_RS02480	COG2207	Transcriptional regulator
SSP_RS02490	COG1263	PTS System
SSP_RS02490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SSP_RS02510	COG1283	sodium-dependent phosphate transmembrane transporter activity
SSP_RS02515	COG1028	Short-chain dehydrogenase reductase Sdr
SSP_RS02520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SSP_RS02525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SSP_RS02530	COG1288	antiporter activity
SSP_RS02535	COG1349	DNA-binding transcription factor activity
SSP_RS02540	COG1063	alcohol dehydrogenase
SSP_RS02545	COG2376	Dihydroxyacetone kinase
SSP_RS02555	COG0698	ribose 5-phosphate isomerase
SSP_RS02565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SSP_RS02570	COG0492	ferredoxin-NADP+ reductase activity
SSP_RS02580	COG2814	Major facilitator Superfamily
SSP_RS02585	COG0604	alcohol dehydrogenase
SSP_RS02600	COG0463	Glycosyl transferase, family 2
SSP_RS02600	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SSP_RS02605	COG1620	l-lactate permease
SSP_RS02610	COG0438	transferase activity, transferring glycosyl groups
SSP_RS02620	COG3850	Histidine kinase
SSP_RS02620	COG5002	protein histidine kinase activity
SSP_RS02625	COG0745	RESPONSE REGULATOR receiver
SSP_RS02630	COG0577	efflux transmembrane transporter activity
SSP_RS02635	COG1136	(ABC) transporter
SSP_RS02650	COG4640	response to antibiotic
SSP_RS02655	COG2814	Major facilitator Superfamily
SSP_RS02665	COG1566	PFAM secretion protein HlyD family protein
SSP_RS02670	COG2814	Major facilitator Superfamily
SSP_RS02695	COG0598	Magnesium transport protein CorA
SSP_RS02700	COG1304	FMN binding
SSP_RS02705	COG0786	glutamate:sodium symporter activity
SSP_RS02720	COG1757	Na H antiporter
SSP_RS02725	COG2094	Belongs to the DNA glycosylase MPG family
SSP_RS02730	COG3152	Membrane
SSP_RS02735	COG1069	ribulokinase activity
SSP_RS02740	COG4152	abc transporter atp-binding protein
SSP_RS02745	COG1668	transmembrane transport
SSP_RS02750	COG2017	converts alpha-aldose to the beta-anomer
SSP_RS02755	COG2258	MOSC domain
SSP_RS02760	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SSP_RS02765	COG1266	CAAX protease self-immunity
SSP_RS02775	COG0583	DNA-binding transcription factor activity
SSP_RS02780	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
SSP_RS02785	COG1228	amidohydrolase
SSP_RS02790	COG0659	secondary active sulfate transmembrane transporter activity
SSP_RS02795	COG1473	amidohydrolase
SSP_RS02800	COG1028	Short-chain dehydrogenase reductase Sdr
SSP_RS02805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SSP_RS02825	COG2801	Transposase and inactivated derivatives
SSP_RS02835	COG1263	PTS System
SSP_RS02835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SSP_RS02845	COG0385	Bile acid
SSP_RS02850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
SSP_RS02875	COG1113	amino acid transport
SSP_RS02880	COG1785	Belongs to the alkaline phosphatase family
SSP_RS02885	COG1737	Transcriptional regulator
SSP_RS02890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SSP_RS02890	COG1263	PTS System
SSP_RS02895	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
SSP_RS02915	COG0483	inositol monophosphate 1-phosphatase activity
SSP_RS02920	COG1316	TRANSCRIPTIONal
SSP_RS02925	COG3383	formate dehydrogenase (NAD+) activity
SSP_RS02940	COG4193	domain, Protein
SSP_RS02950	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SSP_RS02955	COG2076	Multidrug Resistance protein
SSP_RS02960	COG2076	Multidrug Resistance protein
SSP_RS02965	COG3942	CHAP domain
SSP_RS02980	COG1757	Na H antiporter
SSP_RS02985	COG3942	CHAP domain
SSP_RS03015	COG0765	amino acid transport
SSP_RS03020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
SSP_RS03025	COG1126	abc transporter atp-binding protein
SSP_RS03030	COG1960	acyl-CoA dehydrogenase activity
SSP_RS03035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SSP_RS03040	COG1268	BioY protein
SSP_RS03050	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
SSP_RS03055	COG1609	Transcriptional regulator
SSP_RS03060	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SSP_RS03065	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SSP_RS03070	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
SSP_RS03075	COG0725	ABC transporter, periplasmic molybdate-binding protein
SSP_RS03080	COG4149	molybdate abc transporter
SSP_RS03095	COG1510	regulation of RNA biosynthetic process
SSP_RS03100	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SSP_RS03105	COG0521	Mo-molybdopterin cofactor biosynthetic process
SSP_RS03110	COG0315	cyclic pyranopterin monophosphate synthase activity
SSP_RS03120	COG1763	Mo-molybdopterin cofactor biosynthetic process
SSP_RS03135	COG0746	molybdenum cofactor guanylyltransferase activity
SSP_RS03140	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SSP_RS03150	COG2814	Major facilitator Superfamily
SSP_RS03170	COG2348	transferase activity, transferring amino-acyl groups
SSP_RS03175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
SSP_RS03195	COG4975	Glucose uptake
SSP_RS03205	COG0551	DNA topoisomerase type I activity
SSP_RS03205	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SSP_RS03210	COG2252	PERMEase
SSP_RS03220	COG0051	transcription antitermination factor activity, RNA binding
SSP_RS03225	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SSP_RS03230	COG0088	Forms part of the polypeptide exit tunnel
SSP_RS03235	COG0089	rRNA binding
SSP_RS03240	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SSP_RS03245	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SSP_RS03250	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SSP_RS03255	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SSP_RS03260	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SSP_RS03265	COG0255	Belongs to the universal ribosomal protein uL29 family
SSP_RS03270	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
SSP_RS03275	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SSP_RS03280	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
SSP_RS03285	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SSP_RS03290	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SSP_RS03295	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
SSP_RS03300	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SSP_RS03305	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
SSP_RS03310	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SSP_RS03315	COG1841	ribosomal large subunit assembly
SSP_RS03320	COG0200	Binds to the 23S rRNA
SSP_RS03325	COG0201	protein transport
SSP_RS03330	COG0563	adenylate kinase activity
SSP_RS03340	COG0257	Belongs to the bacterial ribosomal protein bL36 family
SSP_RS03345	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SSP_RS03350	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SSP_RS03355	COG0202	RNA polymerase activity
SSP_RS03360	COG0203	ribosomal protein L17
SSP_RS03365	COG1122	ATPase activity
SSP_RS03370	COG1122	ATPase activity
SSP_RS03380	COG0101	tRNA pseudouridine synthase activity
SSP_RS03385	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
SSP_RS03390	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SSP_RS03400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SSP_RS03405	COG2130	NADP-dependent
SSP_RS03410	COG0604	alcohol dehydrogenase
SSP_RS03415	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SSP_RS03430	COG1302	Protein conserved in bacteria
SSP_RS03435	COG4264	IucA IucC family
SSP_RS03440	COG2814	Major facilitator Superfamily
SSP_RS03445	COG4264	IucA IucC family
SSP_RS03450	COG3457	Alanine racemase
SSP_RS03455	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
SSP_RS03460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SSP_RS03465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SSP_RS03470	COG3314	Sporulation integral membrane protein YlbJ
SSP_RS03475	COG2329	Antibiotic biosynthesis monooxygenase
SSP_RS03485	COG1988	membrane-bound metal-dependent
SSP_RS03490	COG4284	Utp--glucose-1-phosphate uridylyltransferase
SSP_RS03495	COG1272	protein, Hemolysin III
SSP_RS03510	COG0489	protein tyrosine kinase activity
SSP_RS03565	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
SSP_RS03575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SSP_RS03580	COG0246	Mannitol dehydrogenase
SSP_RS03590	COG3711	transcriptional antiterminator
SSP_RS03595	COG2213	PTS system mannitol-specific
SSP_RS03610	COG1119	ATPase activity
SSP_RS03635	COG0640	Transcriptional regulator
SSP_RS03640	COG0702	epimerase
SSP_RS03645	COG2186	Transcriptional regulator
SSP_RS03650	COG1482	cell wall glycoprotein biosynthetic process
SSP_RS03660	COG2855	membrane
SSP_RS03675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SSP_RS03680	COG0783	Belongs to the Dps family
SSP_RS03685	COG0813	purine-nucleoside phosphorylase activity
SSP_RS03690	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SSP_RS03695	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SSP_RS03700	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
SSP_RS03710	COG1854	S-ribosylhomocysteine lyase activity
SSP_RS03730	COG5146	pantothenate kinase activity
SSP_RS03735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SSP_RS03740	COG3343	RNA polymerase activity
SSP_RS03745	COG0504	CTP synthase activity
SSP_RS03750	COG0191	fructose-bisphosphate aldolase activity
SSP_RS03755	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SSP_RS03765	COG1012	belongs to the aldehyde dehydrogenase family
SSP_RS03770	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
SSP_RS03775	COG0254	rRNA binding
SSP_RS03780	COG1435	thymidine kinase activity
SSP_RS03785	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
SSP_RS03790	COG2890	protein-(glutamine-N5) methyltransferase activity
SSP_RS03795	COG0009	L-threonylcarbamoyladenylate synthase
SSP_RS03800	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SSP_RS03805	COG4475	Protein of unknown function (DUF436)
SSP_RS03810	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SSP_RS03815	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SSP_RS03820	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
SSP_RS03830	COG0356	it plays a direct role in the translocation of protons across the membrane
SSP_RS03835	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SSP_RS03840	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
SSP_RS03845	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
SSP_RS03850	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
SSP_RS03855	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
SSP_RS03860	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
SSP_RS03865	COG0355	proton-transporting ATP synthase activity, rotational mechanism
SSP_RS03875	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
SSP_RS03880	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
SSP_RS03890	COG0629	single-stranded DNA binding
SSP_RS03895	COG1388	LysM domain
SSP_RS03900	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SSP_RS03910	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
SSP_RS03915	COG0352	thiamine-phosphate diphosphorylase activity
SSP_RS03920	COG0706	membrane insertase activity
SSP_RS03925	COG1418	mRNA catabolic process
SSP_RS03935	COG1937	Protein conserved in bacteria
SSP_RS03945	COG0772	Belongs to the SEDS family
SSP_RS03950	COG1181	Belongs to the D-alanine--D-alanine ligase family
SSP_RS03955	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
SSP_RS03960	COG0513	Belongs to the DEAD box helicase family
SSP_RS03970	COG3428	Bacterial PH domain
SSP_RS03975	COG3402	PFAM membrane-flanked domain
SSP_RS03980	COG0736	holo-[acyl-carrier-protein] synthase activity
SSP_RS03985	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
SSP_RS03995	COG2337	Toxic component of a toxin-antitoxin (TA) module
SSP_RS04000	COG2208	phosphoserine phosphatase activity
SSP_RS04015	COG1191	sigma factor activity
SSP_RS04020	COG1191	sigma factor activity
SSP_RS04025	COG2183	response to ionizing radiation
SSP_RS04030	COG3091	SprT-like family
SSP_RS04065	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SSP_RS04070	COG0066	3-isopropylmalate dehydratase activity
SSP_RS04075	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
SSP_RS04080	COG0473	3-isopropylmalate dehydrogenase activity
SSP_RS04085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
SSP_RS04090	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
SSP_RS04095	COG0440	acetolactate synthase activity
SSP_RS04100	COG0028	Belongs to the TPP enzyme family
SSP_RS04105	COG0129	dihydroxy-acid dehydratase activity
SSP_RS04110	COG0802	atpase or kinase
SSP_RS04115	COG1214	PFAM Peptidase M22, glycoprotease
SSP_RS04120	COG0456	acetyltransferase
SSP_RS04125	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
SSP_RS04135	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SSP_RS04140	COG0488	(ABC) transporter
SSP_RS04145	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
SSP_RS04150	COG2391	methyltransferase activity
SSP_RS04155	COG0425	Belongs to the sulfur carrier protein TusA family
SSP_RS04160	COG1609	Transcriptional regulator
SSP_RS04165	COG1621	beta-fructofuranosidase activity
SSP_RS04170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SSP_RS04175	COG3279	Response regulator of the LytR AlgR family
SSP_RS04180	COG3290	protein histidine kinase activity
SSP_RS04190	COG4512	PFAM Accessory gene regulator B
SSP_RS04195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
SSP_RS04215	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
SSP_RS04220	COG0459	protein refolding
SSP_RS04255	COG1725	Transcriptional regulator
SSP_RS04260	COG1129	ABC transporter
SSP_RS04260	COG0842	Transport permease protein
SSP_RS04275	COG1131	(ABC) transporter
SSP_RS04315	COG2706	6-phosphogluconolactonase activity
SSP_RS04320	COG1012	belongs to the aldehyde dehydrogenase family
SSP_RS04325	COG1227	inorganic diphosphatase activity
SSP_RS04330	COG1335	isochorismatase
SSP_RS04340	COG0471	metal ion transport
SSP_RS04345	COG0077	Prephenate dehydratase
SSP_RS04355	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
SSP_RS04360	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SSP_RS04365	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
SSP_RS04375	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SSP_RS04380	COG4496	protein, YerC YecD
SSP_RS04390	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
SSP_RS04400	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SSP_RS04405	COG4851	CamS sex pheromone cAM373 precursor
SSP_RS04410	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SSP_RS04415	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SSP_RS04420	COG0154	amidase activity
SSP_RS04425	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SSP_RS04430	COG1597	lipid kinase activity
SSP_RS04435	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
SSP_RS04445	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SSP_RS04455	COG1528	Iron-storage protein
SSP_RS04480	COG2801	Transposase and inactivated derivatives
SSP_RS04485	COG4129	membrane
SSP_RS04490	COG0024	Methionine aminopeptidase
SSP_RS04505	COG4585	Histidine kinase
SSP_RS04510	COG2197	response regulator
SSP_RS04515	COG1295	ribonuclease BN
SSP_RS04525	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SSP_RS04530	COG4840	Belongs to the UPF0435 family
SSP_RS04535	COG2309	aminopeptidase activity
SSP_RS04540	COG1607	acyl-coa hydrolase
SSP_RS04545	COG0535	radical SAM domain protein
SSP_RS04550	COG0693	protein deglycase activity
SSP_RS04555	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SSP_RS04560	COG2137	regulation of response to DNA damage stimulus
SSP_RS04570	COG1134	teichoic acid transport
SSP_RS04580	COG1988	membrane-bound metal-dependent
SSP_RS04590	COG3557	Belongs to the UPF0374 family
SSP_RS04600	COG4129	membrane
SSP_RS04605	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SSP_RS04610	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SSP_RS04615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SSP_RS04620	COG0735	belongs to the Fur family
SSP_RS04785	COG1126	abc transporter atp-binding protein
SSP_RS04790	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
SSP_RS04800	COG0363	glucosamine-6-phosphate deaminase activity
SSP_RS04815	COG0114	fumarate hydratase activity
SSP_RS04820	COG0564	pseudouridine synthase activity
SSP_RS04825	COG2203	Gaf domain
SSP_RS04825	COG4585	Histidine kinase
SSP_RS04830	COG2197	response regulator
SSP_RS04845	COG1682	transport, permease protein
SSP_RS04850	COG0788	formyltetrahydrofolate deformylase activity
SSP_RS04860	COG4399	Belongs to the UPF0754 family
SSP_RS04865	COG3679	Belongs to the UPF0342 family
SSP_RS04870	COG0420	3'-5' exonuclease activity
SSP_RS04875	COG4717	serine-type aminopeptidase activity
SSP_RS04880	COG3481	metal-dependent phosphohydrolase, HD sub domain
SSP_RS04885	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
SSP_RS04900	COG0537	adenosine 5'-monophosphoramidase activity
SSP_RS04905	COG1131	(ABC) transporter
SSP_RS04910	COG4473	ABC transporter
SSP_RS04920	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
SSP_RS04925	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
SSP_RS04930	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
SSP_RS04935	COG3545	Serine hydrolase
SSP_RS04990	COG0318	PFAM AMP-dependent synthetase and ligase
SSP_RS05000	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
SSP_RS05015	COG1506	peptidase
SSP_RS05020	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
SSP_RS05025	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
SSP_RS05035	COG0656	L-ascorbic acid biosynthetic process
SSP_RS05040	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SSP_RS05045	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
SSP_RS05055	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
SSP_RS05085	COG3266	domain, Protein
SSP_RS05085	COG4193	domain, Protein
SSP_RS05085	COG5632	N-Acetylmuramoyl-L-alanine amidase
SSP_RS05090	COG2801	Transposase and inactivated derivatives
SSP_RS05110	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SSP_RS05110	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SSP_RS05115	COG0307	riboflavin synthase, alpha
SSP_RS05120	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SSP_RS05120	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SSP_RS05125	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SSP_RS05135	COG2267	carboxylic ester hydrolase activity
SSP_RS05140	COG0039	L-malate dehydrogenase activity
SSP_RS05150	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
SSP_RS05155	COG1242	4 iron, 4 sulfur cluster binding
SSP_RS05160	COG2814	Major facilitator Superfamily
SSP_RS05165	COG0495	leucyl-tRNA aminoacylation
SSP_RS05175	COG2081	HI0933 family
SSP_RS05180	COG2244	polysaccharide biosynthetic process
SSP_RS05185	COG1187	pseudouridine synthase activity
SSP_RS05195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SSP_RS05200	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
SSP_RS05205	COG0510	thiamine kinase activity
SSP_RS05210	COG0220	tRNA (guanine-N7-)-methyltransferase activity
SSP_RS05215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SSP_RS05220	COG5584	Small secreted protein
SSP_RS05225	COG1363	Peptidase, m42
SSP_RS05230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SSP_RS05235	COG4848	Belongs to the UPF0354 family
SSP_RS05240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SSP_RS05245	COG1674	ftsk spoiiie
SSP_RS05250	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
SSP_RS05255	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
SSP_RS05265	COG1605	Chorismate mutase
SSP_RS05265	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
SSP_RS05270	COG1609	Transcriptional regulator
SSP_RS05275	COG0123	including yeast histone deacetylase and acetoin utilization protein
SSP_RS05280	COG0454	-acetyltransferase
SSP_RS05285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SSP_RS05295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SSP_RS05300	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
SSP_RS05305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SSP_RS05310	COG0204	Acyl-transferase
SSP_RS05315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SSP_RS05315	COG1263	PTS System
SSP_RS05325	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
SSP_RS05335	COG1764	response to oxidative stress
SSP_RS05340	COG0584	glycerophosphoryl diester phosphodiesterase
SSP_RS05350	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SSP_RS05355	COG1956	GAF domain-containing protein
SSP_RS05360	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
SSP_RS05365	COG1104	cysteine desulfurase activity
SSP_RS05370	COG0301	tRNA thio-modification
SSP_RS05380	COG0616	signal peptide processing
SSP_RS05385	COG1714	RDD family
SSP_RS05390	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
SSP_RS05395	COG0827	DNA restriction-modification system
SSP_RS05400	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
SSP_RS05410	COG0589	response to stress
SSP_RS05415	COG0686	Belongs to the AlaDH PNT family
SSP_RS05420	COG3142	Participates in the control of copper homeostasis
SSP_RS05425	COG0006	proline dipeptidase activity
SSP_RS05430	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SSP_RS05440	COG4109	DRTGG domain
SSP_RS05445	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SSP_RS05450	COG0587	DNA-directed DNA polymerase activity
SSP_RS05455	COG0281	malic enzyme
SSP_RS05460	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
SSP_RS05465	COG0825	malonyl-CoA metabolic process
SSP_RS05470	COG0205	6-phosphofructokinase activity
SSP_RS05475	COG0469	pyruvate kinase activity
SSP_RS05480	COG1113	amino acid transport
SSP_RS05485	COG0372	Belongs to the citrate synthase family
SSP_RS05490	COG0538	isocitrate dehydrogenase activity
SSP_RS05495	COG0745	RESPONSE REGULATOR receiver
SSP_RS05500	COG5002	protein histidine kinase activity
SSP_RS05505	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SSP_RS05505	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SSP_RS05510	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
SSP_RS05515	COG0237	dephospho-CoA kinase activity
SSP_RS05520	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SSP_RS05525	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
SSP_RS05535	COG1484	DNA-dependent DNA replication
SSP_RS05540	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SSP_RS05545	COG0833	amino acid
SSP_RS05550	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
SSP_RS05555	COG0291	Belongs to the bacterial ribosomal protein bL35 family
SSP_RS05560	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
SSP_RS05565	COG4112	unkown
SSP_RS05575	COG0544	peptidyl-prolyl cis-trans isomerase activity
SSP_RS05580	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
SSP_RS05585	COG0218	Necessary for normal cell division and for the maintenance of normal septation
SSP_RS05590	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
SSP_RS05595	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
SSP_RS05600	COG0181	hydroxymethylbilane synthase activity
SSP_RS05610	COG0113	porphobilinogen synthase activity
SSP_RS05615	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
SSP_RS05630	COG2818	Glycosylase
SSP_RS05635	COG0525	valine-tRNA ligase activity
SSP_RS05640	COG0285	dihydrofolate synthase activity
SSP_RS05650	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
SSP_RS05655	COG2003	Belongs to the UPF0758 family
SSP_RS05680	COG0261	This protein binds to 23S rRNA in the presence of protein L20
SSP_RS05685	COG2868	ribosomal protein
SSP_RS05690	COG0211	Belongs to the bacterial ribosomal protein bL27 family
SSP_RS05695	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SSP_RS05700	COG4492	Belongs to the UPF0735 family
SSP_RS05705	COG0632	four-way junction helicase activity
SSP_RS05710	COG2255	four-way junction helicase activity
SSP_RS05715	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
SSP_RS05720	COG0343	queuine tRNA-ribosyltransferase activity
SSP_RS05725	COG1862	Preprotein translocase
SSP_RS05730	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SSP_RS05730	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
SSP_RS05735	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
SSP_RS05735	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SSP_RS05740	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SSP_RS05750	COG1490	D-aminoacyl-tRNA deacylase activity
SSP_RS05755	COG0860	N-Acetylmuramoyl-L-alanine amidase
SSP_RS05760	COG0124	histidyl-tRNA synthetase
SSP_RS05765	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
SSP_RS05770	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
SSP_RS05775	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SSP_RS05780	COG1959	2 iron, 2 sulfur cluster binding
SSP_RS05785	COG3237	CsbD-like
SSP_RS05790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SSP_RS05795	COG1132	(ABC) transporter
SSP_RS05800	COG0488	(ABC) transporter
SSP_RS05805	COG1104	cysteine desulfurase activity
SSP_RS05810	COG0482	sulfurtransferase activity
SSP_RS05820	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SSP_RS05825	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SSP_RS05830	COG4472	Bacterial protein of unknown function (DUF965)
SSP_RS05835	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
SSP_RS05840	COG3906	Belongs to the UPF0473 family
SSP_RS05845	COG4122	O-methyltransferase activity
SSP_RS05850	COG0826	peptidase U32
SSP_RS05855	COG0826	peptidase U32
SSP_RS05860	COG0572	uridine kinase
SSP_RS05865	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
SSP_RS05870	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SSP_RS05875	COG1984	allophanate hydrolase subunit 2
SSP_RS05885	COG0439	Biotin carboxylase
SSP_RS05890	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
SSP_RS05895	COG1914	H( )-stimulated, divalent metal cation uptake system
SSP_RS05900	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
SSP_RS05905	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
SSP_RS05910	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SSP_RS05915	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
SSP_RS05920	COG1534	Rna-binding protein
SSP_RS05925	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
SSP_RS05930	COG1713	HD superfamily hydrolase involved in NAD metabolism
SSP_RS05935	COG0799	negative regulation of ribosome biogenesis
SSP_RS05940	COG2226	methyltransferase
SSP_RS05945	COG1596	polysaccharide export
SSP_RS05945	COG1555	photosystem II stabilization
SSP_RS05950	COG2131	deaminase
SSP_RS05955	COG0658	competence protein
SSP_RS05955	COG2333	competence protein COMEC
SSP_RS05960	COG1466	dna polymerase III delta subunit
SSP_RS05965	COG0268	Binds directly to 16S ribosomal RNA
SSP_RS05970	COG0481	GTPase activity
SSP_RS05975	COG0635	Involved in the biosynthesis of porphyrin-containing compound
SSP_RS05980	COG1420	regulation of RNA biosynthetic process
SSP_RS05985	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
SSP_RS05990	COG0443	Heat shock 70 kDa protein
SSP_RS05995	COG0484	heat shock protein binding
SSP_RS06000	COG2264	protein methyltransferase activity
SSP_RS06005	COG1385	rRNA (uridine-N3-)-methyltransferase activity
SSP_RS06010	COG0828	Belongs to the bacterial ribosomal protein bS21 family
SSP_RS06015	COG1030	water channel activity
SSP_RS06020	COG4864	UPF0365 protein
SSP_RS06030	COG1702	phosphate starvation-inducible protein PhoH
SSP_RS06035	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
SSP_RS06045	COG0295	cytidine deaminase activity
SSP_RS06050	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
SSP_RS06055	COG1381	Involved in DNA repair and RecF pathway recombination
SSP_RS06060	COG0423	glycine-tRNA ligase activity
SSP_RS06065	COG0517	IMP dehydrogenase activity
SSP_RS06070	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
SSP_RS06080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
SSP_RS06085	COG2384	SAM-dependent methyltransferase
SSP_RS06090	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
SSP_RS06095	COG0513	Belongs to the DEAD box helicase family
SSP_RS06100	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
SSP_RS06105	COG1121	(ABC) transporter
SSP_RS06110	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SSP_RS06120	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
SSP_RS06125	COG0768	penicillin binding
SSP_RS06130	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SSP_RS06135	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
SSP_RS06140	COG0457	Tetratricopeptide repeat
SSP_RS06140	COG0705	Rhomboid family
SSP_RS06145	COG4483	Protein conserved in bacteria
SSP_RS06150	COG1940	carbohydrate kinase activity
SSP_RS06155	COG0011	TIGRFAM Protein of
SSP_RS06160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
SSP_RS06165	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
SSP_RS06170	COG1459	type II secretion system
SSP_RS06175	COG4537	Required for transformation and DNA binding
SSP_RS06200	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SSP_RS06205	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SSP_RS06210	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SSP_RS06215	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SSP_RS06220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SSP_RS06225	COG0095	Lipoate-protein ligase
SSP_RS06240	COG0006	proline dipeptidase activity
SSP_RS06245	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SSP_RS06250	COG0511	ligase activity, forming carbon-carbon bonds
SSP_RS06255	COG0439	Biotin carboxylase
SSP_RS06260	COG1302	Protein conserved in bacteria
SSP_RS06265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SSP_RS06270	COG1570	exodeoxyribonuclease VII activity
SSP_RS06275	COG1722	exodeoxyribonuclease VII activity
SSP_RS06285	COG1438	arginine binding
SSP_RS06290	COG0497	DNA recombination
SSP_RS06295	COG0280	phosphate acetyltransferase
SSP_RS06300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SSP_RS06305	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
SSP_RS06310	COG0022	dehydrogenase e1 component
SSP_RS06315	COG0508	dehydrogenase complex catalyzes the overall conversion of
SSP_RS06325	COG4129	membrane
SSP_RS06330	COG2195	Cleaves the N-terminal amino acid of tripeptides
SSP_RS06340	COG1609	Transcriptional regulator
SSP_RS06345	COG0366	Alpha amylase catalytic
SSP_RS06355	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
SSP_RS06360	COG1234	tRNA 3'-trailer cleavage
SSP_RS06365	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
SSP_RS06375	COG0667	Aldo Keto reductase
SSP_RS06380	COG0494	nUDIX hydrolase
SSP_RS06385	COG0735	belongs to the Fur family
SSP_RS06390	COG4974	Belongs to the 'phage' integrase family
SSP_RS06400	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
SSP_RS06405	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
SSP_RS06410	COG1187	pseudouridine synthase activity
SSP_RS06415	COG0745	RESPONSE REGULATOR receiver
SSP_RS06430	COG1141	Ferredoxin
SSP_RS06440	COG0514	ATP-dependent DNA helicase (RecQ)
SSP_RS06445	COG1388	LysM domain
SSP_RS06450	COG0492	ferredoxin-NADP+ reductase activity
SSP_RS06455	COG0252	asparaginase activity
SSP_RS06460	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
SSP_RS06465	COG0539	negative regulation of cytoplasmic translation
SSP_RS06470	COG1160	GTP binding
SSP_RS06475	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
SSP_RS06490	COG2226	methyltransferase
SSP_RS06495	COG0142	geranyltranstransferase activity
SSP_RS06500	COG0105	UTP biosynthetic process
SSP_RS06505	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
SSP_RS06510	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
SSP_RS06515	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
SSP_RS06530	COG4347	Protein of unknown function (DUF1405)
SSP_RS06535	COG2738	Putative neutral zinc metallopeptidase
SSP_RS06540	COG1694	Mazg nucleotide pyrophosphohydrolase
SSP_RS06545	COG0438	transferase activity, transferring glycosyl groups
SSP_RS06550	COG0617	tRNA 3'-terminal CCA addition
SSP_RS06555	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SSP_RS06555	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SSP_RS06560	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
SSP_RS06560	COG1199	ATP-dependent helicase activity
SSP_RS06565	COG0017	Asparaginyl-tRNA synthetase
SSP_RS06570	COG3935	DnaD domain protein
SSP_RS06575	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SSP_RS06585	COG4499	WXG100 protein secretion system (Wss), protein YukC
SSP_RS06585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
SSP_RS06590	COG3331	DNA recombination
SSP_RS06600	COG4474	Belongs to the UPF0398 family
SSP_RS06605	COG3599	regulation of cell shape
SSP_RS06610	COG0116	Belongs to the methyltransferase superfamily
SSP_RS06615	COG2962	Rard protein
SSP_RS06630	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
SSP_RS06635	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SSP_RS06640	COG0328	RNA-DNA hybrid ribonuclease activity
SSP_RS06645	COG3545	Serine hydrolase
SSP_RS06650	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
SSP_RS06660	COG1413	lyase activity
SSP_RS06665	COG1413	lyase activity
SSP_RS06675	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
SSP_RS06695	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
SSP_RS06705	COG4479	Belongs to the UPF0346 family
SSP_RS06710	COG0793	Belongs to the peptidase S41A family
SSP_RS06720	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SSP_RS06725	COG0671	phosphoesterase, PA-phosphatase related
SSP_RS06730	COG0745	RESPONSE REGULATOR receiver
SSP_RS06735	COG5002	protein histidine kinase activity
SSP_RS06740	COG0567	Dehydrogenase, E1 component
SSP_RS06745	COG0508	dehydrogenase complex catalyzes the overall conversion of
SSP_RS06785	COG0673	inositol 2-dehydrogenase activity
SSP_RS06790	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SSP_RS06795	COG1121	(ABC) transporter
SSP_RS06820	COG0714	Associated with various cellular activities
SSP_RS06825	COG4548	von Willebrand factor, type A
SSP_RS06830	COG1114	Component of the transport system for branched-chain amino acids
SSP_RS06835	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SSP_RS06840	COG3853	Toxic anion resistance protein (TelA)
SSP_RS06850	COG1254	Belongs to the acylphosphatase family
SSP_RS06860	COG1278	Cold shock
SSP_RS06875	COG1473	amidohydrolase
SSP_RS06880	COG2171	N-acyltransferase activity
SSP_RS06885	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
SSP_RS06890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
SSP_RS06895	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
SSP_RS06900	COG0527	aspartate kinase activity
SSP_RS06910	COG0488	(ABC) transporter
SSP_RS06915	COG2996	Protein conserved in bacteria
SSP_RS06920	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
SSP_RS06925	COG0573	inorganic phosphate transmembrane transporter activity
SSP_RS06930	COG0581	inorganic phosphate transmembrane transporter activity
SSP_RS06935	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SSP_RS06940	COG0704	Plays a role in the regulation of phosphate uptake
SSP_RS06945	COG1164	Oligoendopeptidase f
SSP_RS06955	COG4607	ABC-type enterochelin transport system periplasmic component
SSP_RS06965	COG2348	transferase activity, transferring amino-acyl groups
SSP_RS06970	COG2348	transferase activity, transferring amino-acyl groups
SSP_RS06980	COG0159	tryptophan synthase activity
SSP_RS06985	COG0133	tryptophan synthase activity
SSP_RS06990	COG0135	phosphoribosylanthranilate isomerase activity
SSP_RS06995	COG0134	indole-3-glycerol-phosphate synthase activity
SSP_RS07000	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SSP_RS07005	COG0512	Glutamine amidotransferase of anthranilate synthase
SSP_RS07010	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SSP_RS07020	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SSP_RS07025	COG1363	Peptidase, m42
SSP_RS07040	COG0287	Prephenate dehydrogenase
SSP_RS07045	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
SSP_RS07050	COG1942	4-Oxalocrotonate Tautomerase
SSP_RS07065	COG1879	ABC-type sugar transport system periplasmic component
SSP_RS07070	COG1172	Belongs to the binding-protein-dependent transport system permease family
SSP_RS07075	COG1129	ABC transporter
SSP_RS07080	COG1869	D-ribose catabolic process
SSP_RS07085	COG1609	Transcriptional regulator
SSP_RS07090	COG0392	lysyltransferase activity
SSP_RS07090	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
SSP_RS07095	COG0628	permease
SSP_RS07110	COG3711	transcriptional antiterminator
SSP_RS07115	COG1115	amino acid carrier protein
SSP_RS07120	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SSP_RS07130	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
SSP_RS07135	COG4841	protein insertion into membrane
SSP_RS07140	COG0824	Thioesterase
SSP_RS07145	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
SSP_RS07150	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SSP_RS07155	COG1970	mechanosensitive ion channel activity
SSP_RS07160	COG0419	ATPase involved in DNA repair
SSP_RS07165	COG0420	3'-5' exonuclease activity
SSP_RS07170	COG4846	Membrane protein involved in cytochrome C biogenesis
SSP_RS07180	COG3763	UPF0154 protein
SSP_RS07200	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
SSP_RS07210	COG0516	GMP reductase activity
SSP_RS07215	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
SSP_RS07220	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SSP_RS07225	COG2826	transposase and inactivated derivatives, IS30 family
SSP_RS07235	COG3639	organic phosphonate transmembrane transporter activity
SSP_RS07240	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
SSP_RS07255	COG0737	Belongs to the 5'-nucleotidase family
SSP_RS07265	COG2826	transposase and inactivated derivatives, IS30 family
SSP_RS07270	COG0753	catalase activity
SSP_RS07275	COG0833	amino acid
SSP_RS07285	COG0561	phosphatase activity
SSP_RS07290	COG0083	homoserine kinase activity
SSP_RS07295	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SSP_RS07300	COG0460	homoserine dehydrogenase
SSP_RS07305	COG0527	aspartate kinase activity
SSP_RS07335	COG2197	response regulator
SSP_RS07340	COG2203	Gaf domain
SSP_RS07340	COG4585	Histidine kinase
SSP_RS07345	COG0842	Transport permease protein
SSP_RS07350	COG1131	(ABC) transporter
SSP_RS07360	COG0174	glutamine synthetase
SSP_RS07365	COG0789	Transcriptional regulator
SSP_RS07370	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
SSP_RS07375	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SSP_RS07380	COG0386	Belongs to the glutathione peroxidase family
SSP_RS07385	COG1923	regulation of RNA biosynthetic process
SSP_RS07390	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
SSP_RS07400	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
SSP_RS07405	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SSP_RS07415	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
SSP_RS07430	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
SSP_RS07435	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
SSP_RS07445	COG4550	Control of competence regulator ComK, YlbF/YmcA
SSP_RS07450	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SSP_RS07475	COG1013	pyruvate-flavodoxin oxidoreductase activity
SSP_RS07480	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SSP_RS07480	COG0674	pyruvate-flavodoxin oxidoreductase activity
SSP_RS07485	COG1692	metallophosphoesterase
SSP_RS07495	COG1418	mRNA catabolic process
SSP_RS07500	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
SSP_RS07505	COG1058	Belongs to the CinA family
SSP_RS07505	COG1546	Belongs to the CinA family
SSP_RS07530	COG0300	oxidoreductase activity
SSP_RS07535	COG0612	Peptidase, M16
SSP_RS07540	COG0612	Peptidase, M16
SSP_RS07545	COG2188	Transcriptional regulator
SSP_RS07550	COG1674	ftsk spoiiie
SSP_RS07555	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SSP_RS07560	COG1185	polyribonucleotide nucleotidyltransferase activity
SSP_RS07565	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SSP_RS07570	COG0196	riboflavin kinase activity
SSP_RS07575	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
SSP_RS07580	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
SSP_RS07595	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
SSP_RS07600	COG1358	cellular component organization or biogenesis
SSP_RS07605	COG2740	Nucleic-acid-binding protein implicated in transcription termination
SSP_RS07610	COG0195	Participates in both transcription termination and antitermination
SSP_RS07615	COG0779	Required for maturation of 30S ribosomal subunits
SSP_RS07620	COG2176	DNA-directed DNA polymerase activity
SSP_RS07625	COG0442	prolyl-tRNA aminoacylation
SSP_RS07635	COG4589	Belongs to the CDS family
SSP_RS07640	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SSP_RS07645	COG0233	cytoplasmic translational termination
SSP_RS07650	COG0528	UMP kinase activity
SSP_RS07655	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
SSP_RS07660	COG0052	Belongs to the universal ribosomal protein uS2 family
SSP_RS07665	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
SSP_RS07670	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
SSP_RS07675	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
SSP_RS07680	COG4974	Belongs to the 'phage' integrase family
SSP_RS07685	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
SSP_RS07690	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SSP_RS07695	COG0758	DNA mediated transformation
SSP_RS07705	COG0045	succinate-CoA ligase (ADP-forming) activity
SSP_RS07710	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SSP_RS07720	COG4485	Bacterial membrane protein, YfhO
SSP_RS07730	COG0335	large ribosomal subunit rRNA binding
SSP_RS07735	COG0336	Belongs to the RNA methyltransferase TrmD family
SSP_RS07740	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
SSP_RS07745	COG0228	four-way junction DNA binding
SSP_RS07750	COG1028	Short-chain dehydrogenase reductase Sdr
SSP_RS07755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
SSP_RS07760	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SSP_RS07765	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
SSP_RS07770	COG0552	protein localization to endoplasmic reticulum
SSP_RS07775	COG1196	nuclear chromosome segregation
SSP_RS07780	COG0571	ribonuclease III activity
SSP_RS07785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SSP_RS07800	COG0416	fatty acid biosynthetic process
SSP_RS07805	COG1349	DNA-binding transcription factor activity
SSP_RS07815	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
SSP_RS07820	COG1760	l-serine dehydratase
SSP_RS07825	COG1760	l-serine dehydratase
SSP_RS07830	COG1461	Dihydroxyacetone kinase
SSP_RS07835	COG1302	Protein conserved in bacteria
SSP_RS07840	COG0227	Belongs to the bacterial ribosomal protein bL28 family
SSP_RS07845	COG1564	THIamine pyrophosphokinase
SSP_RS07850	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
SSP_RS07855	COG1162	GTPase activity
SSP_RS07865	COG0631	protein serine/threonine phosphatase activity
SSP_RS07870	COG0820	rRNA (adenine-C2-)-methyltransferase activity
SSP_RS07875	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SSP_RS07875	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SSP_RS07880	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
SSP_RS07885	COG0242	peptide deformylase activity
SSP_RS07895	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
SSP_RS07900	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SSP_RS07905	COG1758	RNA polymerase activity
SSP_RS07910	COG0194	GDP metabolic process
SSP_RS07915	COG1293	RNA-binding protein homologous to eukaryotic snRNP
SSP_RS07925	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SSP_RS07935	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SSP_RS07940	COG0284	orotidine-5'-phosphate decarboxylase activity
SSP_RS07945	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
SSP_RS07950	COG0505	Belongs to the CarA family
SSP_RS07960	COG0540	Belongs to the ATCase OTCase family
SSP_RS07970	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
SSP_RS07975	COG0564	pseudouridine synthase activity
SSP_RS07980	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
SSP_RS07990	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SSP_RS07995	COG3599	regulation of cell shape
SSP_RS08005	COG0762	integral membrane protein
SSP_RS08010	COG1799	cell septum assembly
SSP_RS08015	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
SSP_RS08020	COG1496	oxidoreductase activity
SSP_RS08025	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
SSP_RS08030	COG0849	cell division
SSP_RS08035	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
SSP_RS08040	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
SSP_RS08045	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SSP_RS08050	COG0768	penicillin binding
SSP_RS08055	COG4839	cell division protein FtsL
SSP_RS08060	COG0275	rRNA processing
SSP_RS08065	COG2001	Belongs to the MraZ family
SSP_RS08070	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
SSP_RS08075	COG0454	-acetyltransferase
SSP_RS08080	COG1011	Hydrolase
SSP_RS08105	COG1280	lysine exporter protein (LysE YggA)
SSP_RS08120	COG2801	Transposase and inactivated derivatives
SSP_RS08150	COG1063	alcohol dehydrogenase
SSP_RS08165	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
SSP_RS08170	COG1733	regulation of RNA biosynthetic process
SSP_RS08175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SSP_RS08180	COG0697	spore germination
SSP_RS08190	COG1063	alcohol dehydrogenase
SSP_RS08195	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
SSP_RS08200	COG0693	protein deglycase activity
SSP_RS08205	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
SSP_RS08210	COG4221	oxidoreductase activity
SSP_RS08220	COG1012	belongs to the aldehyde dehydrogenase family
SSP_RS08230	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
SSP_RS08235	COG1063	alcohol dehydrogenase
SSP_RS08240	COG1846	Transcriptional regulator
SSP_RS08245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SSP_RS08270	COG0582	viral genome integration into host DNA
SSP_RS08290	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
SSP_RS08295	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
SSP_RS08300	COG1053	succinate dehydrogenase
SSP_RS08305	COG2009	succinate dehydrogenase
SSP_RS08310	COG0322	excinuclease ABC activity
SSP_RS08315	COG3118	belongs to the thioredoxin family
SSP_RS08320	COG1193	negative regulation of DNA recombination
SSP_RS08325	COG1796	DNA polymerase
SSP_RS08325	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SSP_RS08335	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
SSP_RS08340	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SSP_RS08345	COG0072	phenylalanine-tRNA ligase activity
SSP_RS08350	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
SSP_RS08355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SSP_RS08365	COG0333	Belongs to the bacterial ribosomal protein bL32 family
SSP_RS08375	COG1323	Belongs to the UPF0348 family
SSP_RS08380	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SSP_RS08385	COG0742	ribosomal rna small subunit methyltransferase
SSP_RS08400	COG0584	glycerophosphoryl diester phosphodiesterase
SSP_RS08405	COG3679	Belongs to the UPF0342 family
SSP_RS08425	COG0109	protoheme IX farnesyltransferase activity
SSP_RS08430	COG1612	heme a metabolic process
SSP_RS08440	COG0772	Belongs to the SEDS family
SSP_RS08445	COG4838	Belongs to the UPF0358 family
SSP_RS08450	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SSP_RS08455	COG1217	gtp-binding protein TYPA
SSP_RS08465	COG0483	inositol monophosphate 1-phosphatase activity
SSP_RS08470	COG4493	Belongs to the UPF0637 family
SSP_RS08480	COG1914	H( )-stimulated, divalent metal cation uptake system
SSP_RS08495	COG1177	transmembrane transport
SSP_RS08500	COG1176	ABC-type spermidine putrescine transport system, permease component I
SSP_RS08505	COG3842	ATPase activity
SSP_RS08515	COG4476	Belongs to the UPF0223 family
SSP_RS08555	COG5503	Protein of unknown function (DUF1447)
SSP_RS08560	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
SSP_RS08570	COG0569	domain protein
SSP_RS08575	COG1294	oxidase, subunit
SSP_RS08580	COG1271	oxidase subunit
SSP_RS08595	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
SSP_RS08605	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SSP_RS08620	COG4172	Belongs to the ABC transporter superfamily
SSP_RS08625	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
SSP_RS08630	COG0151	Belongs to the GarS family
SSP_RS08635	COG0138	bifunctional purine biosynthesis protein purh
SSP_RS08645	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
SSP_RS08655	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SSP_RS08660	COG0047	phosphoribosylformylglycinamidine synthase activity
SSP_RS08665	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
SSP_RS08670	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
SSP_RS08675	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
SSP_RS08680	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
SSP_RS08685	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
SSP_RS08690	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
SSP_RS08690	COG1017	nitric oxide dioxygenase activity
SSP_RS08700	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
SSP_RS08705	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
SSP_RS08710	COG1845	cytochrome c oxidase, subunit III
SSP_RS08715	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
SSP_RS08725	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
SSP_RS08730	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SSP_RS08735	COG1316	TRANSCRIPTIONal
SSP_RS08760	COG3594	Acyltransferase
SSP_RS08765	COG0436	Aminotransferase
SSP_RS08775	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
SSP_RS08785	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
SSP_RS08790	COG1169	isochorismate synthase
SSP_RS08795	COG1575	Belongs to the MenA family. Type 1 subfamily
SSP_RS08805	COG2314	TM2 domain
SSP_RS08810	COG1764	response to oxidative stress
SSP_RS08825	COG4903	ComK protein
SSP_RS08840	COG4873	Protein conserved in bacteria
SSP_RS08850	COG0737	Belongs to the 5'-nucleotidase family
SSP_RS08855	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SSP_RS08860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SSP_RS08865	COG0861	Integral membrane protein TerC family
SSP_RS08870	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
SSP_RS08880	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
SSP_RS08885	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
SSP_RS08890	COG2814	Major facilitator Superfamily
SSP_RS08895	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SSP_RS08900	COG2382	esterase
SSP_RS08905	COG1115	amino acid carrier protein
SSP_RS08910	COG0628	permease
SSP_RS08920	COG0569	domain protein
SSP_RS08920	COG0475	glutathione-regulated potassium exporter activity
SSP_RS08925	COG2239	Acts as a magnesium transporter
SSP_RS08930	COG0564	pseudouridine synthase activity
SSP_RS08935	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SSP_RS08940	COG2357	RelA SpoT domain protein
SSP_RS08950	COG4116	CYTH
SSP_RS08955	COG2346	COG2346, Truncated hemoglobins
SSP_RS08960	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
SSP_RS08965	COG2910	NAD(P)H-binding
SSP_RS08970	COG1164	Oligoendopeptidase f
SSP_RS08980	COG4862	establishment of competence for transformation
SSP_RS08985	COG1393	Belongs to the ArsC family
SSP_RS08990	COG0180	Tryptophanyl-tRNA synthetase
SSP_RS08995	COG4166	transmembrane transport
SSP_RS09000	COG4608	Belongs to the ABC transporter superfamily
SSP_RS09005	COG0444	Belongs to the ABC transporter superfamily
SSP_RS09010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SSP_RS09015	COG0601	transmembrane transport
SSP_RS09035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SSP_RS09045	COG0542	response to heat
SSP_RS09060	COG0561	phosphatase activity
SSP_RS09065	COG0446	pyridine nucleotide-disulphide oxidoreductase
SSP_RS09075	COG0179	Fumarylacetoacetate (FAA) hydrolase
SSP_RS09080	COG2311	Membrane
SSP_RS09085	COG1074	ATP-dependent DNA helicase activity
SSP_RS09090	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
SSP_RS09105	COG0398	Pfam SNARE associated Golgi protein
SSP_RS09110	COG0166	Belongs to the GPI family
SSP_RS09115	COG0137	argininosuccinate synthase activity
SSP_RS09120	COG0165	Argininosuccinate lyase
SSP_RS09125	COG0584	glycerophosphoryl diester phosphodiesterase
SSP_RS09135	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
SSP_RS09140	COG1902	pentaerythritol trinitrate reductase activity
SSP_RS09145	COG1098	S1 RNA binding domain
SSP_RS09150	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
SSP_RS09160	COG2111	Na H antiporter
SSP_RS09160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SSP_RS09165	COG2111	Na H antiporter
SSP_RS09170	COG1006	Multisubunit Na H antiporter MnhC subunit
SSP_RS09175	COG0651	ATP synthesis coupled electron transport
SSP_RS09180	COG1863	multisubunit Na H antiporter MnhE subunit
SSP_RS09185	COG2212	antiporter activity
SSP_RS09190	COG1320	monovalent cation:proton antiporter activity
SSP_RS09200	COG2050	protein possibly involved in aromatic compounds catabolism
SSP_RS09205	COG2056	Na+-H+ antiporter family
SSP_RS09210	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SSP_RS09215	COG1252	NADH dehydrogenase
SSP_RS09220	COG0316	Belongs to the HesB IscA family
SSP_RS09225	COG4844	belongs to the
SSP_RS09230	COG1252	NADH dehydrogenase
SSP_RS09235	COG4837	Protein of unknown function (DUF1462)
SSP_RS09240	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
SSP_RS09245	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
SSP_RS09250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
SSP_RS09255	COG1696	Membrane protein involved in D-alanine export
SSP_RS09260	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
SSP_RS09275	COG0647	UMP catabolic process
SSP_RS09280	COG2445	Protein of unknown function DUF86
SSP_RS09290	COG4470	Protein conserved in bacteria
SSP_RS09295	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
SSP_RS09300	COG0737	Belongs to the 5'-nucleotidase family
SSP_RS09305	COG0730	response to heat
SSP_RS09310	COG1801	Protein of unknown function DUF72
SSP_RS09315	COG2070	2-Nitropropane dioxygenase
SSP_RS09320	COG1253	flavin adenine dinucleotide binding
SSP_RS09325	COG0719	Fe-S assembly protein
SSP_RS09330	COG0822	iron-sulfur transferase activity
SSP_RS09335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SSP_RS09340	COG0719	Fe-S assembly protein
SSP_RS09345	COG0396	ATPase activity
SSP_RS09355	COG1253	flavin adenine dinucleotide binding
SSP_RS09365	COG1464	Belongs to the NlpA lipoprotein family
SSP_RS09370	COG2011	ABC-type metal ion transport system permease component
SSP_RS09375	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SSP_RS09380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SSP_RS09385	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SSP_RS09390	COG0509	glycine decarboxylation via glycine cleavage system
SSP_RS09395	COG1393	Belongs to the ArsC family
SSP_RS09400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
SSP_RS09405	COG0778	Nitroreductase
SSP_RS09410	COG0710	3-dehydroquinate dehydratase activity
SSP_RS09415	COG1764	response to oxidative stress
SSP_RS09430	COG2851	Citrate transporter
SSP_RS09445	COG2314	TM2 domain
SSP_RS09485	COG0346	lactoylglutathione lyase activity
SSP_RS09530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
SSP_RS09535	COG0546	phosphoglycolate phosphatase activity
SSP_RS09545	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
SSP_RS09550	COG0557	exoribonuclease II activity
SSP_RS09555	COG1647	Serine aminopeptidase, S33
SSP_RS09560	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
SSP_RS09575	COG0148	phosphopyruvate hydratase activity
SSP_RS09580	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SSP_RS09585	COG0149	triose-phosphate isomerase activity
SSP_RS09590	COG0126	phosphoglycerate kinase activity
SSP_RS09620	COG1090	epimerase
SSP_RS09630	COG0740	serine-type endopeptidase activity
SSP_RS09650	COG0346	lactoylglutathione lyase activity
SSP_RS09750	COG1396	sequence-specific DNA binding
SSP_RS09765	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SSP_RS09770	COG1481	regulation of sporulation
SSP_RS09775	COG0391	Required for morphogenesis under gluconeogenic growth conditions
SSP_RS09780	COG1660	Displays ATPase and GTPase activities
SSP_RS09785	COG0492	ferredoxin-NADP+ reductase activity
SSP_RS09795	COG0110	maltose O-acetyltransferase activity
SSP_RS09800	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
SSP_RS09805	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
SSP_RS09815	COG0556	nucleotide-excision repair
SSP_RS09830	COG3942	CHAP domain
SSP_RS09830	COG1388	LysM domain
SSP_RS09835	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
SSP_RS09840	COG0653	protein targeting
SSP_RS09845	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
SSP_RS09850	COG1040	competence protein
SSP_RS09855	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
SSP_RS09865	COG1739	Uncharacterized protein family UPF0029
SSP_RS09870	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SSP_RS09875	COG2199	diguanylate cyclase activity
SSP_RS09890	COG2195	Cleaves the N-terminal amino acid of tripeptides
SSP_RS09895	COG1929	Belongs to the glycerate kinase type-1 family
SSP_RS09915	COG0812	UDP-N-acetylmuramate dehydrogenase activity
SSP_RS09930	COG4607	ABC-type enterochelin transport system periplasmic component
SSP_RS09935	COG4604	ABC transporter, ATP-binding protein
SSP_RS09940	COG4605	iron ion homeostasis
SSP_RS09945	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SSP_RS09950	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SSP_RS09955	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SSP_RS09960	COG1780	Probably involved in ribonucleotide reductase function
SSP_RS09970	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
SSP_RS09975	COG3104	oligopeptide transport
SSP_RS09980	COG3104	oligopeptide transport
SSP_RS09985	COG1597	lipid kinase activity
SSP_RS09995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
SSP_RS10000	COG1174	glycine betaine transport
SSP_RS10010	COG0514	ATP-dependent DNA helicase (RecQ)
SSP_RS10015	COG0488	(ABC) transporter
SSP_RS10025	COG1368	sulfuric ester hydrolase activity
SSP_RS10035	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
SSP_RS10045	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
SSP_RS10050	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
SSP_RS10050	COG0512	Glutamine amidotransferase of anthranilate synthase
SSP_RS10055	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
SSP_RS10060	COG0720	synthase
SSP_RS10065	COG0602	queuosine metabolic process
SSP_RS10080	COG0463	Glycosyl transferase, family 2
SSP_RS10085	COG0656	L-ascorbic acid biosynthetic process
SSP_RS10090	COG1253	flavin adenine dinucleotide binding
SSP_RS10095	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
SSP_RS10100	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SSP_RS10100	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
SSP_RS10100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
SSP_RS10105	COG1105	Belongs to the carbohydrate kinase PfkB family
SSP_RS10110	COG1349	DNA-binding transcription factor activity
SSP_RS10115	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
SSP_RS10120	COG1210	Utp--glucose-1-phosphate uridylyltransferase
SSP_RS10150	COG0039	L-malate dehydrogenase activity
SSP_RS10155	COG0586	Pfam SNARE associated Golgi protein
SSP_RS10165	COG4989	oxidoreductase activity
SSP_RS10180	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
SSP_RS10185	COG4988	ABC transporter
SSP_RS10190	COG1968	undecaprenyl-diphosphatase activity
SSP_RS10200	COG1671	Belongs to the UPF0178 family
SSP_RS10205	COG1611	Belongs to the LOG family
SSP_RS10210	COG1279	arginine transmembrane transporter activity
SSP_RS10215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SSP_RS10245	COG2814	Major facilitator Superfamily
SSP_RS10250	COG2839	Protein conserved in bacteria
SSP_RS10255	COG2814	Major facilitator Superfamily
SSP_RS10260	COG0583	DNA-binding transcription factor activity
SSP_RS10270	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SSP_RS10280	COG0217	transcriptional regulatory protein
SSP_RS10300	COG1388	LysM domain
SSP_RS10300	COG3942	CHAP domain
SSP_RS10305	COG0306	phosphate transporter
SSP_RS10310	COG1392	Phosphate transport regulator
SSP_RS10315	COG2205	protein histidine kinase activity
SSP_RS10320	COG0745	RESPONSE REGULATOR receiver
SSP_RS10325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SSP_RS10335	COG0657	acetylesterase activity
SSP_RS10340	COG3949	Membrane
SSP_RS10350	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
SSP_RS10355	COG1461	Dihydroxyacetone kinase
SSP_RS10360	COG2376	Dihydroxyacetone kinase
SSP_RS10365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SSP_RS10370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
SSP_RS10375	COG1120	ATPase activity
SSP_RS10380	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
SSP_RS10385	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SSP_RS10390	COG1132	(ABC) transporter
SSP_RS10400	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
SSP_RS10405	COG1216	Glycosyl transferase, family 2
SSP_RS10405	COG1442	glycosyl transferase family 8
SSP_RS10410	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SSP_RS10415	COG1682	transport, permease protein
SSP_RS10420	COG1134	teichoic acid transport
SSP_RS10425	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
SSP_RS10440	COG1121	(ABC) transporter
SSP_RS10445	COG1108	ABC-type Mn2 Zn2 transport systems permease components
SSP_RS10450	COG0803	Belongs to the bacterial solute-binding protein 9 family
SSP_RS10460	COG1320	monovalent cation:proton antiporter activity
SSP_RS10465	COG2212	antiporter activity
SSP_RS10470	COG1863	multisubunit Na H antiporter MnhE subunit
SSP_RS10475	COG0651	ATP synthesis coupled electron transport
SSP_RS10480	COG1006	Multisubunit Na H antiporter MnhC subunit
SSP_RS10485	COG2111	Na H antiporter
SSP_RS10490	COG2111	Na H antiporter
SSP_RS10490	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SSP_RS10530	COG0596	Alpha beta hydrolase
SSP_RS10545	COG2267	carboxylic ester hydrolase activity
SSP_RS10550	COG0546	phosphoglycolate phosphatase activity
SSP_RS10555	COG4139	cobalamin transport
SSP_RS10560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SSP_RS10565	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SSP_RS10570	COG0018	arginyl-trna synthetase
SSP_RS10585	COG1078	dGTPase activity
SSP_RS10590	COG0456	acetyltransferase
SSP_RS10595	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
SSP_RS10600	COG0667	Aldo Keto reductase
SSP_RS10605	COG4844	belongs to the
SSP_RS10625	COG0095	Lipoate-protein ligase
SSP_RS10630	COG0280	phosphate acetyltransferase
SSP_RS10635	COG3253	May function as heme-dependent peroxidase
SSP_RS10650	COG0477	Major facilitator Superfamily
SSP_RS10655	COG1846	Transcriptional regulator
SSP_RS10665	COG2363	Small membrane protein
SSP_RS10675	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
SSP_RS10680	COG0351	phosphomethylpyrimidine kinase
SSP_RS10700	COG0534	Mate efflux family protein
SSP_RS10725	COG0183	Belongs to the thiolase family
SSP_RS10730	COG0318	PFAM AMP-dependent synthetase and ligase
SSP_RS10740	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
SSP_RS10745	COG0363	glucosamine-6-phosphate deaminase activity
SSP_RS10755	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
SSP_RS10760	COG1469	GTP cyclohydrolase I activity
SSP_RS10765	COG1846	Transcriptional regulator
SSP_RS10770	COG0431	NADPH-dependent FMN reductase
SSP_RS10775	COG0561	phosphatase activity
SSP_RS10785	COG1428	Deoxynucleoside kinase
SSP_RS10790	COG1428	Deoxynucleoside kinase
SSP_RS10800	COG0546	phosphoglycolate phosphatase activity
SSP_RS10820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
SSP_RS10835	COG2814	Major facilitator Superfamily
SSP_RS10840	COG2824	Alkylphosphonate utilization operon protein PhnA
SSP_RS10850	COG1113	amino acid transport
SSP_RS10855	COG2040	homocysteine
SSP_RS10860	COG0833	amino acid
SSP_RS10870	COG0010	Belongs to the arginase family
SSP_RS10875	COG1914	H( )-stimulated, divalent metal cation uptake system
SSP_RS10885	COG1069	ribulokinase activity
SSP_RS10890	COG1063	alcohol dehydrogenase
SSP_RS10895	COG2814	Major facilitator Superfamily
SSP_RS10900	COG1349	DNA-binding transcription factor activity
SSP_RS10905	COG1132	(ABC) transporter
SSP_RS10920	COG0583	DNA-binding transcription factor activity
SSP_RS10945	COG0667	Aldo Keto reductase
SSP_RS10955	COG3477	response to acidic pH
SSP_RS10970	COG1682	transport, permease protein
SSP_RS10985	COG1028	Short-chain dehydrogenase reductase Sdr
SSP_RS10990	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
SSP_RS10995	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
SSP_RS11025	COG1473	amidohydrolase
SSP_RS11030	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SSP_RS11035	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SSP_RS11040	COG0049	tRNA binding
SSP_RS11045	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
SSP_RS11055	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SSP_RS11060	COG0085	RNA polymerase activity
SSP_RS11065	COG2813	Specifically methylates the guanine in position
SSP_RS11070	COG0222	ribosome binding
SSP_RS11075	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
SSP_RS11080	COG0081	regulation of translation
SSP_RS11085	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SSP_RS11090	COG0250	Participates in transcription elongation, termination and antitermination
SSP_RS11100	COG0267	Belongs to the bacterial ribosomal protein bL33 family
SSP_RS11115	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
SSP_RS11120	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
SSP_RS11125	COG0215	cysteine-tRNA ligase activity
SSP_RS11130	COG1045	serine acetyltransferase
SSP_RS11135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SSP_RS11140	COG4956	integral membrane protein (PIN domain superfamily)
SSP_RS11145	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
SSP_RS11150	COG0542	response to heat
SSP_RS11155	COG3869	Catalyzes the specific phosphorylation of arginine residues in
SSP_RS11160	COG3880	PFAM UvrB UvrC protein
SSP_RS11165	COG4463	regulation of RNA biosynthetic process
SSP_RS11170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
SSP_RS11175	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SSP_RS11180	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SSP_RS11185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SSP_RS11270	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
SSP_RS11275	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
SSP_RS11295	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
SSP_RS11300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SSP_RS11315	COG1098	S1 RNA binding domain
SSP_RS11325	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
SSP_RS11330	COG3956	TIGRFAM MazG family protein
SSP_RS11335	COG2244	polysaccharide biosynthetic process
SSP_RS11340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SSP_RS11345	COG0193	aminoacyl-tRNA hydrolase activity
SSP_RS11350	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
SSP_RS11355	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SSP_RS11360	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
SSP_RS11365	COG2088	sporulation resulting in formation of a cellular spore
SSP_RS11370	COG0251	oxidation-reduction process
SSP_RS11375	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SSP_RS11380	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
SSP_RS11385	COG4466	Protein conserved in bacteria
SSP_RS11390	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SSP_RS11395	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SSP_RS11400	COG0084	hydrolase, TatD family'
SSP_RS11405	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SSP_RS11405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SSP_RS11410	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
SSP_RS11415	COG2827	Endonuclease containing a URI domain
SSP_RS11420	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
SSP_RS11425	COG4467	Involved in initiation control of chromosome replication
SSP_RS11430	COG1774	PSP1 C-terminal conserved region
SSP_RS11435	COG0470	DNA polymerase III
SSP_RS11440	COG3870	Protein conserved in bacteria
SSP_RS11445	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SSP_RS11450	COG1982	Orn Lys Arg decarboxylase major
SSP_RS11470	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
SSP_RS11475	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
SSP_RS11480	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
SSP_RS11490	COG2188	Transcriptional regulator
SSP_RS11495	COG0366	Alpha amylase catalytic
SSP_RS11500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
SSP_RS11500	COG1263	PTS System
SSP_RS11510	COG0493	'glutamate synthase
SSP_RS11515	COG0070	glutamate synthase
SSP_RS11515	COG0069	glutamate synthase activity
SSP_RS11515	COG0067	glutamate synthase
SSP_RS11520	COG0583	DNA-binding transcription factor activity
SSP_RS11535	COG0004	ammonium transporteR
SSP_RS11540	COG0494	nUDIX hydrolase
SSP_RS11550	COG3942	CHAP domain
SSP_RS11550	COG1388	LysM domain
SSP_RS11560	COG0129	dihydroxy-acid dehydratase activity
SSP_RS11580	COG0733	neurotransmitter:sodium symporter activity
SSP_RS11585	COG1114	Component of the transport system for branched-chain amino acids
SSP_RS11590	COG5646	InterPro IPR014922
SSP_RS11610	COG4195	phage-related replication protein
SSP_RS11615	COG2807	transmembrane transport
SSP_RS11620	COG0456	acetyltransferase
SSP_RS11620	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
SSP_RS11625	COG2814	Major facilitator Superfamily
SSP_RS11635	COG2814	Major facilitator Superfamily
SSP_RS11690	COG0519	Catalyzes the synthesis of GMP from XMP
SSP_RS11690	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SSP_RS11695	COG0517	IMP dehydrogenase activity
SSP_RS11695	COG0516	GMP reductase activity
SSP_RS11700	COG2233	PERMEase
SSP_RS11705	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SSP_RS11725	COG1823	symporter activity
SSP_RS11735	COG0778	Nitroreductase
SSP_RS11740	COG3620	sequence-specific DNA binding
SSP_RS11745	COG0450	alkyl hydroperoxide reductase
SSP_RS11750	COG3634	alkyl hydroperoxide reductase activity
SSP_RS11785	COG1280	lysine exporter protein (LysE YggA)
SSP_RS11820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SSP_RS11840	COG4195	phage-related replication protein
SSP_RS11845	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SSP_RS11855	COG1522	sequence-specific DNA binding
SSP_RS11870	COG2808	Putative FMN-binding domain
SSP_RS11910	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
SSP_RS11920	COG0360	Binds together with S18 to 16S ribosomal RNA
SSP_RS11935	COG0012	GTP binding
SSP_RS11940	COG4481	Protein conserved in bacteria
SSP_RS11945	COG0668	transmembrane transport
SSP_RS11950	COG5609	conserved protein (DUF2294)
SSP_RS11955	COG3002	Belongs to the UPF0753 family
SSP_RS11960	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SSP_RS11975	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
SSP_RS12000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
SSP_RS12010	COG2814	Major facilitator Superfamily
SSP_RS12015	COG1473	amidohydrolase
SSP_RS12040	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
SSP_RS12055	COG0529	Catalyzes the synthesis of activated sulfate
SSP_RS12060	COG2046	Belongs to the sulfate adenylyltransferase family
SSP_RS12065	COG0730	response to heat
SSP_RS12085	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SSP_RS12090	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SSP_RS12095	COG0175	sulfate reduction
SSP_RS12110	COG1475	DNA binding
SSP_RS12115	COG0626	cystathionine gamma-synthase activity
SSP_RS12120	COG0626	cystathionine gamma-synthase activity
SSP_RS12125	COG0646	methionine synthase
SSP_RS12125	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
SSP_RS12130	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
SSP_RS12140	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
SSP_RS12165	COG0183	Belongs to the thiolase family
SSP_RS12175	COG1960	acyl-CoA dehydrogenase activity
SSP_RS12180	COG0318	PFAM AMP-dependent synthetase and ligase
SSP_RS12190	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
SSP_RS12200	COG0561	phosphatase activity
SSP_RS12205	COG0531	amino acid
SSP_RS12210	COG0656	L-ascorbic acid biosynthetic process
SSP_RS12240	COG1966	Carbon starvation protein
SSP_RS12245	COG1475	DNA binding
SSP_RS12250	COG0357	Ribosomal RNA small subunit methyltransferase G
SSP_RS12255	COG0445	tRNA wobble uridine modification
SSP_RS12260	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
SSP_RS12265	COG0594	ribonuclease P activity
SSP_RS12545	COG2986	histidine ammonia-lyase
SSP_RS12575	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
SSP_RS12605	COG2190	(PTS) system
SSP_RS12610	COG0463	Glycosyl transferase, family 2
SSP_RS12610	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
SSP_RS12620	COG0386	Belongs to the glutathione peroxidase family