locus-tag	class	description
LH95_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LH95_RS00010	COG0592	DNA-directed DNA polymerase activity
LH95_RS00020	COG2501	S4 domain
LH95_RS00030	COG0187	DNA topoisomerase II activity
LH95_RS00040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LH95_RS00045	COG2986	histidine ammonia-lyase
LH95_RS00055	COG2353	YceI-like domain
LH95_RS00060	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
LH95_RS00070	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LH95_RS00075	COG4241	membrane
LH95_RS00080	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
LH95_RS00085	COG0359	binds to the 23S rRNA
LH95_RS00090	COG0305	Participates in initiation and elongation during chromosome replication
LH95_RS00095	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LH95_RS00110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LH95_RS00130	COG0745	RESPONSE REGULATOR receiver
LH95_RS00135	COG5002	protein histidine kinase activity
LH95_RS00140	COG4863	YycH protein
LH95_RS00150	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LH95_RS00160	COG0747	negative chemotaxis
LH95_RS00175	COG0444	Belongs to the ABC transporter superfamily
LH95_RS00180	COG1124	(ABC) transporter
LH95_RS00185	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LH95_RS00225	COG1131	(ABC) transporter
LH95_RS00240	COG1215	transferase activity, transferring glycosyl groups
LH95_RS00240	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LH95_RS00260	COG1136	(ABC) transporter
LH95_RS00265	COG1609	Transcriptional regulator
LH95_RS00270	COG1621	beta-fructofuranosidase activity
LH95_RS00285	COG0415	Belongs to the DNA photolyase family
LH95_RS00300	COG2376	Dihydroxyacetone kinase
LH95_RS00305	COG1461	Dihydroxyacetone kinase
LH95_RS00310	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
LH95_RS00330	COG0753	catalase activity
LH95_RS00335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH95_RS00340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH95_RS00345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LH95_RS00355	COG2423	ornithine cyclodeaminase activity
LH95_RS00360	COG4264	IucA IucC family
LH95_RS00370	COG4264	IucA IucC family
LH95_RS00375	COG4264	IucA IucC family
LH95_RS00385	COG0019	diaminopimelate decarboxylase activity
LH95_RS00390	COG1475	DNA binding
LH95_RS00395	COG0706	membrane insertase activity
LH95_RS00405	COG1869	D-ribose catabolic process
LH95_RS00410	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LH95_RS00420	COG1288	antiporter activity
LH95_RS00450	COG1288	antiporter activity
LH95_RS00480	COG2197	response regulator
LH95_RS00485	COG4585	Histidine kinase
LH95_RS00490	COG0842	Transport permease protein
LH95_RS00495	COG1131	(ABC) transporter
LH95_RS00505	COG1737	Transcriptional regulator
LH95_RS00510	COG1263	PTS System
LH95_RS00510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LH95_RS00515	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LH95_RS00565	COG1695	Transcriptional regulator
LH95_RS00575	COG3477	response to acidic pH
LH95_RS00600	COG3711	transcriptional antiterminator
LH95_RS00615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LH95_RS00635	COG2235	arginine
LH95_RS00650	COG4716	Myosin-crossreactive antigen
LH95_RS00655	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LH95_RS00700	COG2188	Transcriptional regulator
LH95_RS00725	COG2388	GCN5-related N-acetyl-transferase
LH95_RS00735	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LH95_RS00755	COG2723	6-phospho-beta-galactosidase activity
LH95_RS00760	COG2188	Transcriptional regulator
LH95_RS00765	COG0492	ferredoxin-NADP+ reductase activity
LH95_RS00770	COG1846	Transcriptional regulator
LH95_RS00775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LH95_RS00790	COG0346	lactoylglutathione lyase activity
LH95_RS00800	COG1012	belongs to the aldehyde dehydrogenase family
LH95_RS00800	COG1454	alcohol dehydrogenase
LH95_RS00805	COG0471	metal ion transport
LH95_RS00810	COG1827	regulation of RNA biosynthetic process
LH95_RS00820	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LH95_RS00825	COG0157	Belongs to the NadC ModD family
LH95_RS00830	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LH95_RS00845	COG0366	Alpha amylase catalytic
LH95_RS00850	COG2188	Transcriptional regulator
LH95_RS00855	COG2222	sugar isomerase
LH95_RS00860	COG1105	Belongs to the carbohydrate kinase PfkB family
LH95_RS00865	COG3684	Belongs to the aldolase LacD family
LH95_RS00875	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LH95_RS00875	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LH95_RS00880	COG3715	PTS system
LH95_RS00885	COG3716	PTS system mannose fructose sorbose family IID component
LH95_RS00895	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LH95_RS00915	COG3314	Sporulation integral membrane protein YlbJ
LH95_RS00920	COG1414	Transcriptional regulator
LH95_RS00925	COG0531	amino acid
LH95_RS00945	COG1063	alcohol dehydrogenase
LH95_RS00950	COG1620	l-lactate permease
LH95_RS00955	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LH95_RS00960	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LH95_RS00985	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LH95_RS00990	COG2910	NAD(P)H-binding
LH95_RS00995	COG2814	Major facilitator Superfamily
LH95_RS01000	COG1335	isochorismatase
LH95_RS01010	COG1063	alcohol dehydrogenase
LH95_RS01030	COG2318	DinB family
LH95_RS01035	COG0753	catalase activity
LH95_RS01045	COG0783	Belongs to the Dps family
LH95_RS01055	COG0436	Aminotransferase
LH95_RS01090	COG2814	Major facilitator Superfamily
LH95_RS01095	COG2162	N-hydroxyarylamine O-acetyltransferase activity
LH95_RS01105	COG1335	isochorismatase
LH95_RS01125	COG0431	NADPH-dependent FMN reductase
LH95_RS01135	COG4932	domain protein
LH95_RS01140	COG0456	acetyltransferase
LH95_RS01145	COG1755	Isoprenylcysteine carboxyl methyltransferase
LH95_RS01150	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
LH95_RS01155	COG0579	oxidoreductase
LH95_RS01200	COG1073	alpha beta
LH95_RS01220	COG0438	transferase activity, transferring glycosyl groups
LH95_RS01225	COG0183	Belongs to the thiolase family
LH95_RS01230	COG1250	3-hydroxyacyl-CoA dehydrogenase
LH95_RS01230	COG1024	Enoyl-CoA hydratase
LH95_RS01235	COG1960	acyl-CoA dehydrogenase activity
LH95_RS01240	COG0318	PFAM AMP-dependent synthetase and ligase
LH95_RS01255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH95_RS01265	COG1116	anion transmembrane transporter activity
LH95_RS01275	COG0563	adenylate kinase activity
LH95_RS01285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LH95_RS01310	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LH95_RS01310	COG3711	transcriptional antiterminator
LH95_RS01315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LH95_RS01325	COG3037	sugar-specific permease SgaT UlaA
LH95_RS01330	COG1328	CTP reductase activity
LH95_RS01335	COG0602	queuosine metabolic process
LH95_RS01350	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LH95_RS01355	COG1942	4-Oxalocrotonate Tautomerase
LH95_RS01370	COG0803	Belongs to the bacterial solute-binding protein 9 family
LH95_RS01370	COG3443	Belongs to the bacterial solute-binding protein 9 family
LH95_RS01395	COG2207	Transcriptional regulator
LH95_RS01395	COG4753	response regulator
LH95_RS01415	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LH95_RS01420	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LH95_RS01425	COG2211	Major facilitator Superfamily
LH95_RS01430	COG1957	nucleoside hydrolase
LH95_RS01440	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LH95_RS01445	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LH95_RS01450	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
LH95_RS01455	COG2807	transmembrane transport
LH95_RS01460	COG1476	TRANSCRIPTIONal
LH95_RS01465	COG0586	Pfam SNARE associated Golgi protein
LH95_RS01480	COG1510	regulation of RNA biosynthetic process
LH95_RS01485	COG1012	belongs to the aldehyde dehydrogenase family
LH95_RS01490	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
LH95_RS01500	COG0107	imidazoleglycerol-phosphate synthase activity
LH95_RS01510	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LH95_RS01515	COG0131	Imidazoleglycerol-phosphate dehydratase
LH95_RS01520	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LH95_RS01530	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LH95_RS01535	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
LH95_RS01570	COG2376	Dihydroxyacetone kinase
LH95_RS01575	COG1461	Dihydroxyacetone kinase
LH95_RS01585	COG2824	Alkylphosphonate utilization operon protein PhnA
LH95_RS01590	COG1012	belongs to the aldehyde dehydrogenase family
LH95_RS01600	COG0596	Alpha beta hydrolase
LH95_RS01610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LH95_RS01610	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LH95_RS01610	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LH95_RS01620	COG3942	CHAP domain
LH95_RS01620	COG1705	Flagellar rod assembly protein muramidase FlgJ
LH95_RS01630	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LH95_RS01645	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LH95_RS01650	COG0747	negative chemotaxis
LH95_RS01675	COG0463	Glycosyl transferase, family 2
LH95_RS01675	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LH95_RS01695	COG3181	Tripartite tricarboxylate transporter family receptor
LH95_RS01700	COG0778	Nitroreductase
LH95_RS01705	COG3001	Fructosamine kinase
LH95_RS01725	COG1136	(ABC) transporter
LH95_RS01730	COG0577	efflux transmembrane transporter activity
LH95_RS01745	COG4413	Urea transporter
LH95_RS01750	COG0831	urea catabolic process
LH95_RS01755	COG0832	Belongs to the urease beta subunit family
LH95_RS01760	COG0804	urea catabolic process
LH95_RS01765	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LH95_RS01770	COG1063	alcohol dehydrogenase
LH95_RS01775	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LH95_RS01780	COG0717	Belongs to the dCTP deaminase family
LH95_RS01785	COG0523	cobalamin synthesis protein
LH95_RS01800	COG0583	DNA-binding transcription factor activity
LH95_RS01810	COG1346	cytolysis
LH95_RS01815	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH95_RS01820	COG4605	iron ion homeostasis
LH95_RS01825	COG4604	ABC transporter, ATP-binding protein
LH95_RS01830	COG4607	ABC-type enterochelin transport system periplasmic component
LH95_RS01845	COG0778	Nitroreductase
LH95_RS01850	COG2357	RelA SpoT domain protein
LH95_RS01860	COG3942	CHAP domain
LH95_RS01875	COG0596	Alpha beta hydrolase
LH95_RS01900	COG1028	Short-chain dehydrogenase reductase Sdr
LH95_RS01920	COG3835	regulator
LH95_RS01930	COG3961	Belongs to the TPP enzyme family
LH95_RS01935	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LH95_RS01940	COG0512	Glutamine amidotransferase of anthranilate synthase
LH95_RS01950	COG0134	indole-3-glycerol-phosphate synthase activity
LH95_RS01955	COG0135	phosphoribosylanthranilate isomerase activity
LH95_RS01960	COG0133	tryptophan synthase activity
LH95_RS01965	COG0159	tryptophan synthase activity
LH95_RS01980	COG1132	(ABC) transporter
LH95_RS01985	COG1132	(ABC) transporter
LH95_RS01995	COG1115	amino acid carrier protein
LH95_RS02000	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
LH95_RS02005	COG2814	Major facilitator Superfamily
LH95_RS02010	COG2271	Major facilitator Superfamily
LH95_RS02015	COG3764	Sortase (surface protein transpeptidase)
LH95_RS02020	COG1929	Belongs to the glycerate kinase type-1 family
LH95_RS02025	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
LH95_RS02035	COG1174	glycine betaine transport
LH95_RS02060	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LH95_RS02070	COG0702	epimerase
LH95_RS02080	COG0444	Belongs to the ABC transporter superfamily
LH95_RS02085	COG4608	Belongs to the ABC transporter superfamily
LH95_RS02090	COG0601	transmembrane transport
LH95_RS02095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH95_RS02110	COG1760	l-serine dehydratase
LH95_RS02115	COG1760	l-serine dehydratase
LH95_RS02145	COG0471	metal ion transport
LH95_RS02160	COG0454	-acetyltransferase
LH95_RS02175	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LH95_RS02180	COG2146	nitrite reductase [NAD(P)H] activity
LH95_RS02185	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LH95_RS02185	COG1648	precorrin-2 dehydrogenase activity
LH95_RS02190	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
LH95_RS02195	COG1140	nitrate reductase beta subunit
LH95_RS02205	COG2181	nitrate reductase activity
LH95_RS02215	COG4585	Histidine kinase
LH95_RS02220	COG2197	response regulator
LH95_RS02230	COG2223	nitrite transmembrane transporter activity
LH95_RS02240	COG0039	L-malate dehydrogenase activity
LH95_RS02245	COG1363	Peptidase, m42
LH95_RS02260	COG2807	transmembrane transport
LH95_RS02280	COG1283	sodium-dependent phosphate transmembrane transporter activity
LH95_RS02305	COG2814	Major facilitator Superfamily
LH95_RS02310	COG0604	alcohol dehydrogenase
LH95_RS02320	COG1620	l-lactate permease
LH95_RS02330	COG0438	transferase activity, transferring glycosyl groups
LH95_RS02360	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LH95_RS02380	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LH95_RS02390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LH95_RS02410	COG1304	FMN binding
LH95_RS02415	COG0523	cobalamin synthesis protein
LH95_RS02420	COG0786	glutamate:sodium symporter activity
LH95_RS02425	COG2207	Transcriptional regulator
LH95_RS02435	COG1695	Transcriptional regulator
LH95_RS02450	COG1757	Na H antiporter
LH95_RS02455	COG2094	Belongs to the DNA glycosylase MPG family
LH95_RS02465	COG1288	antiporter activity
LH95_RS02475	COG1668	transmembrane transport
LH95_RS02480	COG1742	UPF0060 membrane protein
LH95_RS02485	COG2017	converts alpha-aldose to the beta-anomer
LH95_RS02490	COG1476	TRANSCRIPTIONal
LH95_RS02495	COG2258	MOSC domain
LH95_RS02505	COG1266	CAAX protease self-immunity
LH95_RS02510	COG0010	Belongs to the arginase family
LH95_RS02515	COG0583	DNA-binding transcription factor activity
LH95_RS02520	COG3314	Sporulation integral membrane protein YlbJ
LH95_RS02530	COG1228	amidohydrolase
LH95_RS02535	COG0659	secondary active sulfate transmembrane transporter activity
LH95_RS02540	COG1473	amidohydrolase
LH95_RS02560	COG0385	Bile acid
LH95_RS02590	COG1113	amino acid transport
LH95_RS02615	COG1316	TRANSCRIPTIONal
LH95_RS02630	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
LH95_RS02635	COG3383	formate dehydrogenase (NAD+) activity
LH95_RS02660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LH95_RS02665	COG2076	Multidrug Resistance protein
LH95_RS02670	COG2076	Multidrug Resistance protein
LH95_RS02685	COG1757	Na H antiporter
LH95_RS02695	COG3942	CHAP domain
LH95_RS02715	COG1960	acyl-CoA dehydrogenase activity
LH95_RS02720	COG2832	Protein of unknown function (DUF454)
LH95_RS02725	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
LH95_RS02730	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LH95_RS02740	COG2186	Transcriptional regulator
LH95_RS02745	COG1940	carbohydrate kinase activity
LH95_RS02750	COG1268	BioY protein
LH95_RS02765	COG1609	Transcriptional regulator
LH95_RS02770	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LH95_RS02775	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LH95_RS02780	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
LH95_RS02785	COG0725	ABC transporter, periplasmic molybdate-binding protein
LH95_RS02790	COG4149	molybdate abc transporter
LH95_RS02795	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LH95_RS02800	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LH95_RS02805	COG0521	Mo-molybdopterin cofactor biosynthetic process
LH95_RS02810	COG0315	cyclic pyranopterin monophosphate synthase activity
LH95_RS02825	COG0314	molybdopterin synthase activity
LH95_RS02835	COG0746	molybdenum cofactor guanylyltransferase activity
LH95_RS02840	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LH95_RS02865	COG2348	transferase activity, transferring amino-acyl groups
LH95_RS02870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LH95_RS02875	COG0436	Aminotransferase
LH95_RS02900	COG2252	PERMEase
LH95_RS02915	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LH95_RS02920	COG0088	Forms part of the polypeptide exit tunnel
LH95_RS02925	COG0089	rRNA binding
LH95_RS02930	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LH95_RS02935	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LH95_RS02940	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LH95_RS02945	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LH95_RS02955	COG0255	Belongs to the universal ribosomal protein uL29 family
LH95_RS02965	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LH95_RS02970	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LH95_RS02975	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LH95_RS02980	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LH95_RS02985	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LH95_RS03005	COG1841	ribosomal large subunit assembly
LH95_RS03015	COG0201	protein transport
LH95_RS03030	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LH95_RS03040	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LH95_RS03045	COG0202	RNA polymerase activity
LH95_RS03050	COG0203	ribosomal protein L17
LH95_RS03055	COG1122	ATPase activity
LH95_RS03060	COG1122	ATPase activity
LH95_RS03070	COG0101	tRNA pseudouridine synthase activity
LH95_RS03080	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LH95_RS03095	COG0018	arginyl-trna synthetase
LH95_RS03110	COG1335	isochorismatase
LH95_RS03115	COG0488	(ABC) transporter
LH95_RS03120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH95_RS03125	COG0604	alcohol dehydrogenase
LH95_RS03130	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LH95_RS03145	COG1302	Protein conserved in bacteria
LH95_RS03150	COG2814	Major facilitator Superfamily
LH95_RS03155	COG4264	IucA IucC family
LH95_RS03160	COG2814	Major facilitator Superfamily
LH95_RS03165	COG4264	IucA IucC family
LH95_RS03170	COG3457	Alanine racemase
LH95_RS03175	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
LH95_RS03180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH95_RS03185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH95_RS03190	COG3314	Sporulation integral membrane protein YlbJ
LH95_RS03200	COG1988	membrane-bound metal-dependent
LH95_RS03205	COG4284	Utp--glucose-1-phosphate uridylyltransferase
LH95_RS03230	COG2814	Major facilitator Superfamily
LH95_RS03235	COG0489	protein tyrosine kinase activity
LH95_RS03300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LH95_RS03320	COG2186	Transcriptional regulator
LH95_RS03325	COG1482	cell wall glycoprotein biosynthetic process
LH95_RS03350	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
LH95_RS03380	COG5146	pantothenate kinase activity
LH95_RS03390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LH95_RS03405	COG2271	Major facilitator Superfamily
LH95_RS03410	COG4821	SIS domain
LH95_RS03415	COG0191	fructose-bisphosphate aldolase activity
LH95_RS03420	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LH95_RS03425	COG1733	regulation of RNA biosynthetic process
LH95_RS03435	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LH95_RS03440	COG0254	rRNA binding
LH95_RS03450	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LH95_RS03455	COG2890	protein-(glutamine-N5) methyltransferase activity
LH95_RS03460	COG0009	L-threonylcarbamoyladenylate synthase
LH95_RS03465	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LH95_RS03470	COG4475	Protein of unknown function (DUF436)
LH95_RS03480	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LH95_RS03485	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LH95_RS03495	COG0356	it plays a direct role in the translocation of protons across the membrane
LH95_RS03500	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LH95_RS03510	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LH95_RS03515	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LH95_RS03520	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LH95_RS03540	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LH95_RS03550	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LH95_RS03565	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LH95_RS03575	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
LH95_RS03580	COG0352	thiamine-phosphate diphosphorylase activity
LH95_RS03585	COG0706	membrane insertase activity
LH95_RS03600	COG1418	mRNA catabolic process
LH95_RS03610	COG1937	Protein conserved in bacteria
LH95_RS03625	COG2217	Heavy metal translocating P-type atpase
LH95_RS03630	COG0772	Belongs to the SEDS family
LH95_RS03635	COG1181	Belongs to the D-alanine--D-alanine ligase family
LH95_RS03640	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LH95_RS03645	COG0513	Belongs to the DEAD box helicase family
LH95_RS03665	COG0736	holo-[acyl-carrier-protein] synthase activity
LH95_RS03670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LH95_RS03680	COG2337	Toxic component of a toxin-antitoxin (TA) module
LH95_RS03685	COG2208	phosphoserine phosphatase activity
LH95_RS03690	COG1366	Belongs to the anti-sigma-factor antagonist family
LH95_RS03700	COG1191	sigma factor activity
LH95_RS03710	COG3091	SprT-like family
LH95_RS03740	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LH95_RS03750	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LH95_RS03760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LH95_RS03775	COG0028	Belongs to the TPP enzyme family
LH95_RS03780	COG0129	dihydroxy-acid dehydratase activity
LH95_RS03785	COG0802	atpase or kinase
LH95_RS03790	COG1214	PFAM Peptidase M22, glycoprotease
LH95_RS03795	COG0456	acetyltransferase
LH95_RS03800	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LH95_RS03805	COG0488	(ABC) transporter
LH95_RS03810	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
LH95_RS03815	COG2391	methyltransferase activity
LH95_RS03820	COG0425	Belongs to the sulfur carrier protein TusA family
LH95_RS03825	COG1621	beta-fructofuranosidase activity
LH95_RS03845	COG4512	PFAM Accessory gene regulator B
LH95_RS03905	COG0693	protein deglycase activity
LH95_RS03920	COG1464	Belongs to the NlpA lipoprotein family
LH95_RS03925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LH95_RS03945	COG1131	(ABC) transporter
LH95_RS03955	COG1802	Transcriptional regulator
LH95_RS03960	COG1070	Carbohydrate kinase
LH95_RS03965	COG2610	gluconate transmembrane transporter activity
LH95_RS04000	COG2706	6-phosphogluconolactonase activity
LH95_RS04005	COG1012	belongs to the aldehyde dehydrogenase family
LH95_RS04015	COG1227	inorganic diphosphatase activity
LH95_RS04020	COG1335	isochorismatase
LH95_RS04030	COG0077	Prephenate dehydratase
LH95_RS04040	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LH95_RS04045	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LH95_RS04050	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
LH95_RS04055	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LH95_RS04060	COG4496	protein, YerC YecD
LH95_RS04065	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
LH95_RS04070	COG0210	DNA helicase
LH95_RS04075	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LH95_RS04080	COG4851	CamS sex pheromone cAM373 precursor
LH95_RS04085	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LH95_RS04090	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LH95_RS04095	COG0154	amidase activity
LH95_RS04100	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LH95_RS04110	COG1597	lipid kinase activity
LH95_RS04115	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LH95_RS04130	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LH95_RS04140	COG1528	Iron-storage protein
LH95_RS04155	COG4129	membrane
LH95_RS04160	COG0024	Methionine aminopeptidase
LH95_RS04185	COG0288	reversible hydration of carbon dioxide
LH95_RS04190	COG1295	ribonuclease BN
LH95_RS04200	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LH95_RS04205	COG4840	Belongs to the UPF0435 family
LH95_RS04210	COG2309	aminopeptidase activity
LH95_RS04215	COG1607	acyl-coa hydrolase
LH95_RS04220	COG0535	radical SAM domain protein
LH95_RS04225	COG0693	protein deglycase activity
LH95_RS04230	COG0028	Belongs to the TPP enzyme family
LH95_RS04240	COG2137	regulation of response to DNA damage stimulus
LH95_RS04250	COG1134	teichoic acid transport
LH95_RS04250	COG1388	LysM domain
LH95_RS04260	COG1988	membrane-bound metal-dependent
LH95_RS04280	COG0069	glutamate synthase activity
LH95_RS04285	COG4129	membrane
LH95_RS04290	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LH95_RS04295	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LH95_RS04305	COG0735	belongs to the Fur family
LH95_RS04455	COG1181	Belongs to the D-alanine--D-alanine ligase family
LH95_RS04460	COG1181	Belongs to the D-alanine--D-alanine ligase family
LH95_RS04470	COG0765	amino acid transport
LH95_RS04475	COG1126	abc transporter atp-binding protein
LH95_RS04480	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LH95_RS04490	COG0363	glucosamine-6-phosphate deaminase activity
LH95_RS04500	COG0114	fumarate hydratase activity
LH95_RS04505	COG0248	Ppx GppA phosphatase
LH95_RS04510	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LH95_RS04515	COG0564	pseudouridine synthase activity
LH95_RS04520	COG4585	Histidine kinase
LH95_RS04520	COG2203	Gaf domain
LH95_RS04525	COG2197	response regulator
LH95_RS04530	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LH95_RS04555	COG4399	Belongs to the UPF0754 family
LH95_RS04560	COG3679	Belongs to the UPF0342 family
LH95_RS04565	COG0420	3'-5' exonuclease activity
LH95_RS04575	COG3481	metal-dependent phosphohydrolase, HD sub domain
LH95_RS04580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LH95_RS04590	COG1846	Transcriptional regulator
LH95_RS04600	COG0537	adenosine 5'-monophosphoramidase activity
LH95_RS04605	COG1131	(ABC) transporter
LH95_RS04610	COG4473	ABC transporter
LH95_RS04620	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LH95_RS04625	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LH95_RS04630	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
LH95_RS04635	COG3545	Serine hydrolase
LH95_RS04730	COG0076	glutamate decarboxylase activity
LH95_RS04750	COG0318	PFAM AMP-dependent synthetase and ligase
LH95_RS04760	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
LH95_RS04770	COG1506	peptidase
LH95_RS04775	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LH95_RS04780	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LH95_RS04790	COG0656	L-ascorbic acid biosynthetic process
LH95_RS04795	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LH95_RS04810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LH95_RS04835	COG3266	domain, Protein
LH95_RS04835	COG4193	domain, Protein
LH95_RS04835	COG5632	N-Acetylmuramoyl-L-alanine amidase
LH95_RS04850	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LH95_RS04850	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LH95_RS04860	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LH95_RS04860	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LH95_RS04865	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LH95_RS04870	COG0506	proline dehydrogenase activity
LH95_RS04880	COG2267	carboxylic ester hydrolase activity
LH95_RS04885	COG0039	L-malate dehydrogenase activity
LH95_RS04895	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
LH95_RS04900	COG1242	4 iron, 4 sulfur cluster binding
LH95_RS04905	COG2814	Major facilitator Superfamily
LH95_RS04910	COG0495	leucyl-tRNA aminoacylation
LH95_RS04915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LH95_RS04920	COG2081	HI0933 family
LH95_RS04925	COG2244	polysaccharide biosynthetic process
LH95_RS04930	COG1187	pseudouridine synthase activity
LH95_RS04940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LH95_RS04945	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LH95_RS04950	COG0510	thiamine kinase activity
LH95_RS04955	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LH95_RS04960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LH95_RS04970	COG1363	Peptidase, m42
LH95_RS04975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LH95_RS04985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LH95_RS04990	COG1674	ftsk spoiiie
LH95_RS04995	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LH95_RS05000	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
LH95_RS05010	COG1605	Chorismate mutase
LH95_RS05010	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
LH95_RS05015	COG1609	Transcriptional regulator
LH95_RS05025	COG0454	-acetyltransferase
LH95_RS05030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LH95_RS05035	COG2759	Belongs to the formate--tetrahydrofolate ligase family
LH95_RS05040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LH95_RS05050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LH95_RS05055	COG0204	Acyl-transferase
LH95_RS05065	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LH95_RS05070	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LH95_RS05075	COG1764	response to oxidative stress
LH95_RS05080	COG0584	glycerophosphoryl diester phosphodiesterase
LH95_RS05090	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LH95_RS05095	COG1956	GAF domain-containing protein
LH95_RS05100	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
LH95_RS05105	COG1104	cysteine desulfurase activity
LH95_RS05110	COG0301	tRNA thio-modification
LH95_RS05120	COG0616	signal peptide processing
LH95_RS05130	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LH95_RS05135	COG0827	DNA restriction-modification system
LH95_RS05140	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LH95_RS05145	COG0589	response to stress
LH95_RS05150	COG0686	Belongs to the AlaDH PNT family
LH95_RS05160	COG0006	proline dipeptidase activity
LH95_RS05165	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LH95_RS05175	COG4109	DRTGG domain
LH95_RS05180	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
LH95_RS05190	COG0281	malic enzyme
LH95_RS05195	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LH95_RS05200	COG0825	malonyl-CoA metabolic process
LH95_RS05205	COG0205	6-phosphofructokinase activity
LH95_RS05210	COG0469	pyruvate kinase activity
LH95_RS05215	COG0372	Belongs to the citrate synthase family
LH95_RS05220	COG0538	isocitrate dehydrogenase activity
LH95_RS05225	COG0745	RESPONSE REGULATOR receiver
LH95_RS05230	COG5002	protein histidine kinase activity
LH95_RS05235	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LH95_RS05235	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LH95_RS05240	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LH95_RS05245	COG0237	dephospho-CoA kinase activity
LH95_RS05250	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LH95_RS05255	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LH95_RS05260	COG3611	Membrane attachment protein
LH95_RS05265	COG1484	DNA-dependent DNA replication
LH95_RS05275	COG0833	amino acid
LH95_RS05280	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LH95_RS05285	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LH95_RS05295	COG4112	unkown
LH95_RS05305	COG0544	peptidyl-prolyl cis-trans isomerase activity
LH95_RS05310	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LH95_RS05315	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LH95_RS05320	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LH95_RS05325	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LH95_RS05330	COG0181	hydroxymethylbilane synthase activity
LH95_RS05340	COG0113	porphobilinogen synthase activity
LH95_RS05345	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LH95_RS05355	COG2818	Glycosylase
LH95_RS05360	COG0525	valine-tRNA ligase activity
LH95_RS05365	COG0285	dihydrofolate synthase activity
LH95_RS05375	COG2003	Belongs to the UPF0758 family
LH95_RS05395	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LH95_RS05400	COG2868	ribosomal protein
LH95_RS05415	COG4492	Belongs to the UPF0735 family
LH95_RS05420	COG0632	four-way junction helicase activity
LH95_RS05425	COG2255	four-way junction helicase activity
LH95_RS05430	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LH95_RS05440	COG1862	Preprotein translocase
LH95_RS05445	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LH95_RS05445	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LH95_RS05450	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LH95_RS05450	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LH95_RS05455	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LH95_RS05465	COG1490	D-aminoacyl-tRNA deacylase activity
LH95_RS05470	COG0860	N-Acetylmuramoyl-L-alanine amidase
LH95_RS05480	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LH95_RS05485	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LH95_RS05490	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LH95_RS05495	COG1959	2 iron, 2 sulfur cluster binding
LH95_RS05510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH95_RS05515	COG1104	cysteine desulfurase activity
LH95_RS05520	COG0482	sulfurtransferase activity
LH95_RS05530	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LH95_RS05535	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LH95_RS05540	COG4472	Bacterial protein of unknown function (DUF965)
LH95_RS05545	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LH95_RS05550	COG3906	Belongs to the UPF0473 family
LH95_RS05555	COG4122	O-methyltransferase activity
LH95_RS05560	COG0826	peptidase U32
LH95_RS05565	COG0826	peptidase U32
LH95_RS05570	COG0572	uridine kinase
LH95_RS05580	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LH95_RS05585	COG1984	allophanate hydrolase subunit 2
LH95_RS05590	COG0511	ligase activity, forming carbon-carbon bonds
LH95_RS05595	COG0439	Biotin carboxylase
LH95_RS05600	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LH95_RS05605	COG1914	H( )-stimulated, divalent metal cation uptake system
LH95_RS05615	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LH95_RS05620	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
LH95_RS05625	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
LH95_RS05630	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LH95_RS05635	COG1534	Rna-binding protein
LH95_RS05645	COG1713	HD superfamily hydrolase involved in NAD metabolism
LH95_RS05650	COG0799	negative regulation of ribosome biogenesis
LH95_RS05655	COG2226	methyltransferase
LH95_RS05660	COG1555	photosystem II stabilization
LH95_RS05660	COG1596	polysaccharide export
LH95_RS05665	COG2131	deaminase
LH95_RS05675	COG1466	dna polymerase III delta subunit
LH95_RS05680	COG0268	Binds directly to 16S ribosomal RNA
LH95_RS05690	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LH95_RS05695	COG1420	regulation of RNA biosynthetic process
LH95_RS05710	COG0484	heat shock protein binding
LH95_RS05715	COG2264	protein methyltransferase activity
LH95_RS05720	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LH95_RS05725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LH95_RS05740	COG4864	UPF0365 protein
LH95_RS05750	COG1702	phosphate starvation-inducible protein PhoH
LH95_RS05755	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LH95_RS05760	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LH95_RS05765	COG0295	cytidine deaminase activity
LH95_RS05775	COG1381	Involved in DNA repair and RecF pathway recombination
LH95_RS05780	COG0423	glycine-tRNA ligase activity
LH95_RS05785	COG0517	IMP dehydrogenase activity
LH95_RS05790	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LH95_RS05795	COG0358	DNA primase activity
LH95_RS05800	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LH95_RS05805	COG2384	SAM-dependent methyltransferase
LH95_RS05815	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LH95_RS05820	COG0513	Belongs to the DEAD box helicase family
LH95_RS05825	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LH95_RS05830	COG1121	(ABC) transporter
LH95_RS05835	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LH95_RS05840	COG0735	belongs to the Fur family
LH95_RS05845	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LH95_RS05855	COG0768	penicillin binding
LH95_RS05860	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LH95_RS05865	COG0573	inorganic phosphate transmembrane transporter activity
LH95_RS05870	COG0581	inorganic phosphate transmembrane transporter activity
LH95_RS05875	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LH95_RS05880	COG0704	Plays a role in the regulation of phosphate uptake
LH95_RS05885	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LH95_RS05890	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LH95_RS05895	COG0705	Rhomboid family
LH95_RS05895	COG0457	Tetratricopeptide repeat
LH95_RS05900	COG4483	Protein conserved in bacteria
LH95_RS05905	COG1940	carbohydrate kinase activity
LH95_RS05910	COG0011	TIGRFAM Protein of
LH95_RS05915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LH95_RS05920	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LH95_RS05925	COG1459	type II secretion system
LH95_RS05945	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LH95_RS05950	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LH95_RS05960	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LH95_RS05965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LH95_RS05970	COG0095	Lipoate-protein ligase
LH95_RS05985	COG0006	proline dipeptidase activity
LH95_RS05990	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LH95_RS05995	COG0511	ligase activity, forming carbon-carbon bonds
LH95_RS06000	COG0439	Biotin carboxylase
LH95_RS06005	COG1302	Protein conserved in bacteria
LH95_RS06025	COG0142	geranyltranstransferase activity
LH95_RS06030	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LH95_RS06035	COG1438	arginine binding
LH95_RS06040	COG0497	DNA recombination
LH95_RS06045	COG0280	phosphate acetyltransferase
LH95_RS06050	COG3426	butyrate kinase activity
LH95_RS06055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LH95_RS06060	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LH95_RS06065	COG0022	dehydrogenase e1 component
LH95_RS06070	COG0508	dehydrogenase complex catalyzes the overall conversion of
LH95_RS06080	COG4129	membrane
LH95_RS06085	COG2195	Cleaves the N-terminal amino acid of tripeptides
LH95_RS06100	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LH95_RS06105	COG1234	tRNA 3'-trailer cleavage
LH95_RS06110	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LH95_RS06120	COG0667	Aldo Keto reductase
LH95_RS06125	COG0494	nUDIX hydrolase
LH95_RS06130	COG0735	belongs to the Fur family
LH95_RS06145	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LH95_RS06150	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LH95_RS06155	COG1187	pseudouridine synthase activity
LH95_RS06160	COG0745	RESPONSE REGULATOR receiver
LH95_RS06165	COG5002	protein histidine kinase activity
LH95_RS06175	COG1141	Ferredoxin
LH95_RS06185	COG0514	ATP-dependent DNA helicase (RecQ)
LH95_RS06195	COG0492	ferredoxin-NADP+ reductase activity
LH95_RS06205	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LH95_RS06210	COG0539	negative regulation of cytoplasmic translation
LH95_RS06235	COG2226	methyltransferase
LH95_RS06240	COG0142	geranyltranstransferase activity
LH95_RS06245	COG0105	UTP biosynthetic process
LH95_RS06255	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LH95_RS06265	COG0457	Tetratricopeptide repeat
LH95_RS06270	COG5582	Belongs to the UPF0302 family
LH95_RS06275	COG4347	Protein of unknown function (DUF1405)
LH95_RS06280	COG2738	Putative neutral zinc metallopeptidase
LH95_RS06285	COG1694	Mazg nucleotide pyrophosphohydrolase
LH95_RS06290	COG0438	transferase activity, transferring glycosyl groups
LH95_RS06295	COG0617	tRNA 3'-terminal CCA addition
LH95_RS06305	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LH95_RS06305	COG1199	ATP-dependent helicase activity
LH95_RS06310	COG0017	Asparaginyl-tRNA synthetase
LH95_RS06315	COG3935	DnaD domain protein
LH95_RS06320	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LH95_RS06330	COG4499	WXG100 protein secretion system (Wss), protein YukC
LH95_RS06330	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LH95_RS06335	COG3331	DNA recombination
LH95_RS06345	COG4474	Belongs to the UPF0398 family
LH95_RS06350	COG3599	regulation of cell shape
LH95_RS06355	COG0116	Belongs to the methyltransferase superfamily
LH95_RS06360	COG2962	Rard protein
LH95_RS06365	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
LH95_RS06370	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LH95_RS06380	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LH95_RS06390	COG1413	lyase activity
LH95_RS06425	COG2190	(PTS) system
LH95_RS06430	COG4479	Belongs to the UPF0346 family
LH95_RS06435	COG0793	Belongs to the peptidase S41A family
LH95_RS06445	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LH95_RS06450	COG0671	phosphoesterase, PA-phosphatase related
LH95_RS06460	COG5002	protein histidine kinase activity
LH95_RS06490	COG0714	Associated with various cellular activities
LH95_RS06495	COG4548	von Willebrand factor, type A
LH95_RS06500	COG1114	Component of the transport system for branched-chain amino acids
LH95_RS06505	COG3853	Toxic anion resistance protein (TelA)
LH95_RS06515	COG1254	Belongs to the acylphosphatase family
LH95_RS06525	COG1278	Cold shock
LH95_RS06540	COG1473	amidohydrolase
LH95_RS06545	COG2171	N-acyltransferase activity
LH95_RS06550	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LH95_RS06555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LH95_RS06560	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LH95_RS06565	COG0488	(ABC) transporter
LH95_RS06570	COG2996	Protein conserved in bacteria
LH95_RS06575	COG3711	transcriptional antiterminator
LH95_RS06580	COG1447	Phosphotransferase system cellobiose-specific component IIA
LH95_RS06585	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LH95_RS06585	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LH95_RS06590	COG2723	6-phospho-beta-galactosidase activity
LH95_RS06600	COG0698	ribose 5-phosphate isomerase
LH95_RS06605	COG0698	ribose 5-phosphate isomerase
LH95_RS06635	COG1363	Peptidase, m42
LH95_RS06640	COG0287	Prephenate dehydrogenase
LH95_RS06645	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LH95_RS06675	COG0628	permease
LH95_RS06685	COG3711	transcriptional antiterminator
LH95_RS06690	COG1115	amino acid carrier protein
LH95_RS06695	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LH95_RS06700	COG0187	DNA topoisomerase II activity
LH95_RS06705	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LH95_RS06710	COG4841	protein insertion into membrane
LH95_RS06715	COG0824	Thioesterase
LH95_RS06720	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LH95_RS06725	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
LH95_RS06730	COG1970	mechanosensitive ion channel activity
LH95_RS06745	COG4846	Membrane protein involved in cytochrome C biogenesis
LH95_RS06755	COG3763	UPF0154 protein
LH95_RS06765	COG4224	UPF0291 protein
LH95_RS06775	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LH95_RS06785	COG0516	GMP reductase activity
LH95_RS06800	COG0833	amino acid
LH95_RS06810	COG0561	phosphatase activity
LH95_RS06815	COG0083	homoserine kinase activity
LH95_RS06820	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LH95_RS06825	COG0460	homoserine dehydrogenase
LH95_RS06830	COG0527	aspartate kinase activity
LH95_RS06860	COG1518	maintenance of DNA repeat elements
LH95_RS06875	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LH95_RS06880	COG1525	nuclease
LH95_RS06900	COG1525	nuclease
LH95_RS06910	COG0584	glycerophosphoryl diester phosphodiesterase
LH95_RS06985	COG0789	Transcriptional regulator
LH95_RS06990	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
LH95_RS06995	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LH95_RS07000	COG0386	Belongs to the glutathione peroxidase family
LH95_RS07005	COG1923	regulation of RNA biosynthetic process
LH95_RS07010	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LH95_RS07015	COG2267	carboxylic ester hydrolase activity
LH95_RS07020	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LH95_RS07030	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LH95_RS07040	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
LH95_RS07045	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LH95_RS07050	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LH95_RS07065	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LH95_RS07075	COG1013	pyruvate-flavodoxin oxidoreductase activity
LH95_RS07080	COG0674	pyruvate-flavodoxin oxidoreductase activity
LH95_RS07080	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LH95_RS07085	COG1692	metallophosphoesterase
LH95_RS07110	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LH95_RS07115	COG1546	Belongs to the CinA family
LH95_RS07115	COG1058	Belongs to the CinA family
LH95_RS07135	COG1028	Short-chain dehydrogenase reductase Sdr
LH95_RS07140	COG0612	Peptidase, M16
LH95_RS07145	COG0612	Peptidase, M16
LH95_RS07150	COG2188	Transcriptional regulator
LH95_RS07170	COG1185	polyribonucleotide nucleotidyltransferase activity
LH95_RS07180	COG0196	riboflavin kinase activity
LH95_RS07185	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LH95_RS07190	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LH95_RS07195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LH95_RS07205	COG1131	(ABC) transporter
LH95_RS07210	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LH95_RS07240	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LH95_RS07245	COG1358	cellular component organization or biogenesis
LH95_RS07250	COG2740	Nucleic-acid-binding protein implicated in transcription termination
LH95_RS07255	COG0195	Participates in both transcription termination and antitermination
LH95_RS07260	COG0779	Required for maturation of 30S ribosomal subunits
LH95_RS07270	COG0442	prolyl-tRNA aminoacylation
LH95_RS07280	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LH95_RS07285	COG4589	Belongs to the CDS family
LH95_RS07295	COG0233	cytoplasmic translational termination
LH95_RS07300	COG0528	UMP kinase activity
LH95_RS07305	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LH95_RS07310	COG0052	Belongs to the universal ribosomal protein uS2 family
LH95_RS07315	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
LH95_RS07320	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LH95_RS07325	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LH95_RS07330	COG4974	Belongs to the 'phage' integrase family
LH95_RS07335	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
LH95_RS07340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LH95_RS07345	COG0758	DNA mediated transformation
LH95_RS07355	COG0045	succinate-CoA ligase (ADP-forming) activity
LH95_RS07370	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LH95_RS07385	COG4485	Bacterial membrane protein, YfhO
LH95_RS07395	COG0335	large ribosomal subunit rRNA binding
LH95_RS07400	COG0336	Belongs to the RNA methyltransferase TrmD family
LH95_RS07410	COG0228	four-way junction DNA binding
LH95_RS07415	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LH95_RS07420	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
LH95_RS07425	COG0552	protein localization to endoplasmic reticulum
LH95_RS07430	COG1196	nuclear chromosome segregation
LH95_RS07440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LH95_RS07455	COG0416	fatty acid biosynthetic process
LH95_RS07460	COG1349	DNA-binding transcription factor activity
LH95_RS07470	COG1760	l-serine dehydratase
LH95_RS07475	COG1760	l-serine dehydratase
LH95_RS07480	COG1461	Dihydroxyacetone kinase
LH95_RS07485	COG1302	Protein conserved in bacteria
LH95_RS07490	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LH95_RS07500	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LH95_RS07505	COG1162	GTPase activity
LH95_RS07520	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LH95_RS07525	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LH95_RS07525	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LH95_RS07530	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LH95_RS07550	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LH95_RS07555	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LH95_RS07560	COG1758	RNA polymerase activity
LH95_RS07590	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LH95_RS07595	COG0284	orotidine-5'-phosphate decarboxylase activity
LH95_RS07600	COG0167	dihydroorotate dehydrogenase activity
LH95_RS07610	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LH95_RS07615	COG0505	Belongs to the CarA family
LH95_RS07635	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
LH95_RS07640	COG0564	pseudouridine synthase activity
LH95_RS07650	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LH95_RS07655	COG3599	regulation of cell shape
LH95_RS07665	COG0762	integral membrane protein
LH95_RS07670	COG1799	cell septum assembly
LH95_RS07675	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LH95_RS07680	COG1496	oxidoreductase activity
LH95_RS07685	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LH95_RS07690	COG0849	cell division
LH95_RS07700	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LH95_RS07705	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LH95_RS07710	COG0768	penicillin binding
LH95_RS07715	COG4839	cell division protein FtsL
LH95_RS07720	COG0275	rRNA processing
LH95_RS07725	COG2001	Belongs to the MraZ family
LH95_RS07730	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
LH95_RS07735	COG0454	-acetyltransferase
LH95_RS07740	COG1011	Hydrolase
LH95_RS07745	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LH95_RS07790	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LH95_RS07795	COG1053	succinate dehydrogenase
LH95_RS07800	COG2009	succinate dehydrogenase
LH95_RS07805	COG0322	excinuclease ABC activity
LH95_RS07810	COG3118	belongs to the thioredoxin family
LH95_RS07815	COG1193	negative regulation of DNA recombination
LH95_RS07820	COG1796	DNA polymerase
LH95_RS07820	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LH95_RS07830	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
LH95_RS07835	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LH95_RS07840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LH95_RS07840	COG0072	phenylalanine-tRNA ligase activity
LH95_RS07845	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LH95_RS07850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LH95_RS07855	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LH95_RS07870	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LH95_RS07875	COG0742	ribosomal rna small subunit methyltransferase
LH95_RS07890	COG0584	glycerophosphoryl diester phosphodiesterase
LH95_RS07895	COG3679	Belongs to the UPF0342 family
LH95_RS07910	COG0109	protoheme IX farnesyltransferase activity
LH95_RS07915	COG1612	heme a metabolic process
LH95_RS07925	COG0772	Belongs to the SEDS family
LH95_RS07930	COG4838	Belongs to the UPF0358 family
LH95_RS07935	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LH95_RS07940	COG4896	Protein conserved in bacteria
LH95_RS07945	COG1902	pentaerythritol trinitrate reductase activity
LH95_RS07950	COG1217	gtp-binding protein TYPA
LH95_RS07960	COG0483	inositol monophosphate 1-phosphatase activity
LH95_RS07980	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LH95_RS07985	COG1177	transmembrane transport
LH95_RS07995	COG3842	ATPase activity
LH95_RS08005	COG4476	Belongs to the UPF0223 family
LH95_RS08035	COG0242	peptide deformylase activity
LH95_RS08045	COG5503	Protein of unknown function (DUF1447)
LH95_RS08050	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LH95_RS08055	COG0569	domain protein
LH95_RS08060	COG1294	oxidase, subunit
LH95_RS08065	COG1271	oxidase subunit
LH95_RS08075	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LH95_RS08080	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LH95_RS08090	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LH95_RS08105	COG1122	ATPase activity
LH95_RS08115	COG0151	Belongs to the GarS family
LH95_RS08120	COG0138	bifunctional purine biosynthesis protein purh
LH95_RS08130	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LH95_RS08135	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LH95_RS08140	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LH95_RS08145	COG0047	phosphoribosylformylglycinamidine synthase activity
LH95_RS08150	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LH95_RS08155	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LH95_RS08160	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LH95_RS08165	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LH95_RS08170	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LH95_RS08175	COG0438	transferase activity, transferring glycosyl groups
LH95_RS08190	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LH95_RS08200	COG1845	cytochrome c oxidase, subunit III
LH95_RS08205	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LH95_RS08215	COG3212	peptidase
LH95_RS08225	COG1134	teichoic acid transport
LH95_RS08245	COG0438	transferase activity, transferring glycosyl groups
LH95_RS08250	COG1215	transferase activity, transferring glycosyl groups
LH95_RS08265	COG1682	transport, permease protein
LH95_RS08270	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LH95_RS08275	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LH95_RS08280	COG1316	TRANSCRIPTIONal
LH95_RS08305	COG3594	Acyltransferase
LH95_RS08310	COG0436	Aminotransferase
LH95_RS08315	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
LH95_RS08320	COG2267	carboxylic ester hydrolase activity
LH95_RS08325	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LH95_RS08330	COG1169	isochorismate synthase
LH95_RS08335	COG1575	Belongs to the MenA family. Type 1 subfamily
LH95_RS08340	COG0390	transport system, permease component
LH95_RS08345	COG4619	ABC transporter
LH95_RS08370	COG3344	reverse transcriptase
LH95_RS08390	COG4903	ComK protein
LH95_RS08405	COG4873	Protein conserved in bacteria
LH95_RS08415	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
LH95_RS08415	COG3266	domain, Protein
LH95_RS08415	COG4932	domain protein
LH95_RS08420	COG0737	Belongs to the 5'-nucleotidase family
LH95_RS08430	COG1696	Membrane protein involved in D-alanine export
LH95_RS08440	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
LH95_RS08445	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LH95_RS08450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LH95_RS08455	COG0861	Integral membrane protein TerC family
LH95_RS08470	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LH95_RS08475	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LH95_RS08480	COG2814	Major facilitator Superfamily
LH95_RS08485	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
LH95_RS08490	COG2382	esterase
LH95_RS08495	COG1115	amino acid carrier protein
LH95_RS08500	COG0628	permease
LH95_RS08515	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LH95_RS08530	COG0475	glutathione-regulated potassium exporter activity
LH95_RS08530	COG0569	domain protein
LH95_RS08535	COG2239	Acts as a magnesium transporter
LH95_RS08540	COG0564	pseudouridine synthase activity
LH95_RS08545	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LH95_RS08550	COG2357	RelA SpoT domain protein
LH95_RS08560	COG4116	CYTH
LH95_RS08565	COG2346	COG2346, Truncated hemoglobins
LH95_RS08575	COG1164	Oligoendopeptidase f
LH95_RS08580	COG4469	Competence protein
LH95_RS08585	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LH95_RS08595	COG1393	Belongs to the ArsC family
LH95_RS08600	COG0180	Tryptophanyl-tRNA synthetase
LH95_RS08605	COG4166	transmembrane transport
LH95_RS08610	COG4608	Belongs to the ABC transporter superfamily
LH95_RS08615	COG0444	Belongs to the ABC transporter superfamily
LH95_RS08620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH95_RS08625	COG0601	transmembrane transport
LH95_RS08650	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
LH95_RS08655	COG0542	response to heat
LH95_RS08670	COG0561	phosphatase activity
LH95_RS08685	COG0179	Fumarylacetoacetate (FAA) hydrolase
LH95_RS08690	COG1074	ATP-dependent DNA helicase activity
LH95_RS08695	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
LH95_RS08715	COG0137	argininosuccinate synthase activity
LH95_RS08725	COG0584	glycerophosphoryl diester phosphodiesterase
LH95_RS08740	COG1012	belongs to the aldehyde dehydrogenase family
LH95_RS08745	COG1098	S1 RNA binding domain
LH95_RS08750	COG1278	Cold shock
LH95_RS08770	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LH95_RS08780	COG2111	Na H antiporter
LH95_RS08780	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LH95_RS08785	COG2111	Na H antiporter
LH95_RS08790	COG1006	Multisubunit Na H antiporter MnhC subunit
LH95_RS08795	COG0651	ATP synthesis coupled electron transport
LH95_RS08800	COG1863	multisubunit Na H antiporter MnhE subunit
LH95_RS08805	COG2212	antiporter activity
LH95_RS08810	COG1320	monovalent cation:proton antiporter activity
LH95_RS08820	COG2056	Na+-H+ antiporter family
LH95_RS08825	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LH95_RS08830	COG1252	NADH dehydrogenase
LH95_RS08840	COG0316	Belongs to the HesB IscA family
LH95_RS08845	COG4844	belongs to the
LH95_RS08850	COG1252	NADH dehydrogenase
LH95_RS08855	COG4837	Protein of unknown function (DUF1462)
LH95_RS08860	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LH95_RS08865	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LH95_RS08870	COG0647	UMP catabolic process
LH95_RS08875	COG2445	Protein of unknown function DUF86
LH95_RS08885	COG4470	Protein conserved in bacteria
LH95_RS08890	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LH95_RS08895	COG0737	Belongs to the 5'-nucleotidase family
LH95_RS08900	COG0730	response to heat
LH95_RS08905	COG1801	Protein of unknown function DUF72
LH95_RS08915	COG2070	2-Nitropropane dioxygenase
LH95_RS08920	COG4536	flavin adenine dinucleotide binding
LH95_RS08960	COG0719	Fe-S assembly protein
LH95_RS08965	COG0822	iron-sulfur transferase activity
LH95_RS08975	COG0719	Fe-S assembly protein
LH95_RS08980	COG0396	ATPase activity
LH95_RS08990	COG1464	Belongs to the NlpA lipoprotein family
LH95_RS08995	COG1464	Belongs to the NlpA lipoprotein family
LH95_RS09000	COG2011	ABC-type metal ion transport system permease component
LH95_RS09005	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LH95_RS09010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LH95_RS09015	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
LH95_RS09025	COG1393	Belongs to the ArsC family
LH95_RS09030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LH95_RS09040	COG0710	3-dehydroquinate dehydratase activity
LH95_RS09050	COG1764	response to oxidative stress
LH95_RS09060	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LH95_RS09070	COG2814	Major facilitator Superfamily
LH95_RS09090	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LH95_RS09095	COG0557	exoribonuclease II activity
LH95_RS09100	COG1647	Serine aminopeptidase, S33
LH95_RS09105	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LH95_RS09120	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LH95_RS09125	COG0149	triose-phosphate isomerase activity
LH95_RS09130	COG0126	phosphoglycerate kinase activity
LH95_RS09135	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LH95_RS09155	COG1090	epimerase
LH95_RS09165	COG0740	serine-type endopeptidase activity
LH95_RS09175	COG1481	regulation of sporulation
LH95_RS09180	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LH95_RS09185	COG1660	Displays ATPase and GTPase activities
LH95_RS09190	COG0492	ferredoxin-NADP+ reductase activity
LH95_RS09200	COG0110	maltose O-acetyltransferase activity
LH95_RS09210	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LH95_RS09240	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LH95_RS09245	COG0653	protein targeting
LH95_RS09260	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
LH95_RS09270	COG1739	Uncharacterized protein family UPF0029
LH95_RS09275	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LH95_RS09295	COG2195	Cleaves the N-terminal amino acid of tripeptides
LH95_RS09300	COG1929	Belongs to the glycerate kinase type-1 family
LH95_RS09320	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LH95_RS09330	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LH95_RS09335	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LH95_RS09350	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LH95_RS09355	COG3104	oligopeptide transport
LH95_RS09360	COG3104	oligopeptide transport
LH95_RS09375	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LH95_RS09380	COG1174	glycine betaine transport
LH95_RS09385	COG0517	IMP dehydrogenase activity
LH95_RS09385	COG1125	glycine betaine transport
LH95_RS09390	COG0514	ATP-dependent DNA helicase (RecQ)
LH95_RS09395	COG0488	(ABC) transporter
LH95_RS09405	COG1368	sulfuric ester hydrolase activity
LH95_RS09410	COG1984	allophanate hydrolase subunit 2
LH95_RS09415	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LH95_RS09435	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LH95_RS09435	COG0512	Glutamine amidotransferase of anthranilate synthase
LH95_RS09445	COG0720	synthase
LH95_RS09460	COG2261	transglycosylase associated protein
LH95_RS09470	COG0463	Glycosyl transferase, family 2
LH95_RS09475	COG1253	flavin adenine dinucleotide binding
LH95_RS09480	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LH95_RS09480	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LH95_RS09480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LH95_RS09485	COG1105	Belongs to the carbohydrate kinase PfkB family
LH95_RS09490	COG1349	DNA-binding transcription factor activity
LH95_RS09495	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LH95_RS09500	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LH95_RS09525	COG0039	L-malate dehydrogenase activity
LH95_RS09535	COG4989	oxidoreductase activity
LH95_RS09550	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LH95_RS09555	COG4988	ABC transporter
LH95_RS09560	COG1968	undecaprenyl-diphosphatase activity
LH95_RS09570	COG1671	Belongs to the UPF0178 family
LH95_RS09575	COG1611	Belongs to the LOG family
LH95_RS09605	COG2814	Major facilitator Superfamily
LH95_RS09610	COG0583	DNA-binding transcription factor activity
LH95_RS09625	COG0217	transcriptional regulatory protein
LH95_RS09635	COG2022	thiamine diphosphate biosynthetic process
LH95_RS09645	COG0352	thiamine-phosphate diphosphorylase activity
LH95_RS09660	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LH95_RS09670	COG2205	protein histidine kinase activity
LH95_RS09675	COG0745	RESPONSE REGULATOR receiver
LH95_RS09685	COG2130	NADP-dependent
LH95_RS09690	COG0702	epimerase
LH95_RS09710	COG3942	CHAP domain
LH95_RS09710	COG1388	LysM domain
LH95_RS09715	COG0306	phosphate transporter
LH95_RS09720	COG1392	Phosphate transport regulator
LH95_RS09725	COG0577	efflux transmembrane transporter activity
LH95_RS09730	COG1136	(ABC) transporter
LH95_RS09740	COG0745	RESPONSE REGULATOR receiver
LH95_RS09745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH95_RS09755	COG0657	acetylesterase activity
LH95_RS09760	COG3949	Membrane
LH95_RS09770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH95_RS09775	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH95_RS09780	COG1120	ATPase activity
LH95_RS09785	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
LH95_RS09790	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LH95_RS09835	COG1132	(ABC) transporter
LH95_RS09840	COG1686	Belongs to the peptidase S11 family
LH95_RS09845	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LH95_RS09850	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
LH95_RS09855	COG1682	transport, permease protein
LH95_RS09860	COG1134	teichoic acid transport
LH95_RS09865	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
LH95_RS09880	COG1121	(ABC) transporter
LH95_RS09885	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LH95_RS09890	COG0803	Belongs to the bacterial solute-binding protein 9 family
LH95_RS09895	COG1320	monovalent cation:proton antiporter activity
LH95_RS09900	COG2212	antiporter activity
LH95_RS09905	COG1863	multisubunit Na H antiporter MnhE subunit
LH95_RS09915	COG1006	Multisubunit Na H antiporter MnhC subunit
LH95_RS09920	COG2111	Na H antiporter
LH95_RS09925	COG2111	Na H antiporter
LH95_RS09925	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LH95_RS09930	COG0582	viral genome integration into host DNA
LH95_RS09975	COG0596	Alpha beta hydrolase
LH95_RS09985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH95_RS09990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LH95_RS09995	COG0018	arginyl-trna synthetase
LH95_RS10010	COG1078	dGTPase activity
LH95_RS10020	COG0655	NAD(P)H dehydrogenase (quinone) activity
LH95_RS10025	COG4844	belongs to the
LH95_RS10030	COG0095	Lipoate-protein ligase
LH95_RS10060	COG0471	metal ion transport
LH95_RS10065	COG2814	Major facilitator Superfamily
LH95_RS10070	COG1566	PFAM secretion protein HlyD family protein
LH95_RS10080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LH95_RS10090	COG2363	Small membrane protein
LH95_RS10120	COG0183	Belongs to the thiolase family
LH95_RS10125	COG0318	PFAM AMP-dependent synthetase and ligase
LH95_RS10130	COG0588	phosphoglycerate mutase activity
LH95_RS10135	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LH95_RS10145	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
LH95_RS10150	COG0363	glucosamine-6-phosphate deaminase activity
LH95_RS10180	COG0561	phosphatase activity
LH95_RS10190	COG1428	Deoxynucleoside kinase
LH95_RS10195	COG1428	Deoxynucleoside kinase
LH95_RS10210	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH95_RS10220	COG1473	amidohydrolase
LH95_RS10225	COG0028	Belongs to the TPP enzyme family
LH95_RS10230	COG3527	Alpha-acetolactate decarboxylase
LH95_RS10240	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LH95_RS10245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LH95_RS10250	COG0049	tRNA binding
LH95_RS10255	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LH95_RS10265	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LH95_RS10270	COG0085	RNA polymerase activity
LH95_RS10275	COG2813	Specifically methylates the guanine in position
LH95_RS10285	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LH95_RS10290	COG0081	regulation of translation
LH95_RS10295	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LH95_RS10300	COG0250	Participates in transcription elongation, termination and antitermination
LH95_RS10305	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LH95_RS10325	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
LH95_RS10330	COG0215	cysteine-tRNA ligase activity
LH95_RS10340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LH95_RS10345	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LH95_RS10355	COG4956	integral membrane protein (PIN domain superfamily)
LH95_RS10360	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
LH95_RS10370	COG3869	Catalyzes the specific phosphorylation of arginine residues in
LH95_RS10375	COG3880	PFAM UvrB UvrC protein
LH95_RS10380	COG4463	regulation of RNA biosynthetic process
LH95_RS10385	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LH95_RS10390	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
LH95_RS10395	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
LH95_RS10400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH95_RS10405	COG1289	transmembrane transporter activity
LH95_RS10495	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LH95_RS10505	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LH95_RS10515	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LH95_RS10520	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LH95_RS10535	COG1098	S1 RNA binding domain
LH95_RS10545	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LH95_RS10550	COG3956	TIGRFAM MazG family protein
LH95_RS10555	COG2244	polysaccharide biosynthetic process
LH95_RS10560	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LH95_RS10565	COG0193	aminoacyl-tRNA hydrolase activity
LH95_RS10575	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LH95_RS10580	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LH95_RS10585	COG2088	sporulation resulting in formation of a cellular spore
LH95_RS10590	COG0251	oxidation-reduction process
LH95_RS10595	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LH95_RS10600	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LH95_RS10605	COG4466	Protein conserved in bacteria
LH95_RS10615	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
LH95_RS10620	COG0084	hydrolase, TatD family'
LH95_RS10630	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LH95_RS10635	COG2827	Endonuclease containing a URI domain
LH95_RS10640	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LH95_RS10650	COG1774	PSP1 C-terminal conserved region
LH95_RS10660	COG3870	Protein conserved in bacteria
LH95_RS10665	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LH95_RS10670	COG1982	Orn Lys Arg decarboxylase major
LH95_RS10695	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LH95_RS10700	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LH95_RS10705	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LH95_RS10720	COG0493	'glutamate synthase
LH95_RS10725	COG0069	glutamate synthase activity
LH95_RS10725	COG0067	glutamate synthase
LH95_RS10725	COG0070	glutamate synthase
LH95_RS10730	COG0583	DNA-binding transcription factor activity
LH95_RS10745	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LH95_RS10760	COG1309	transcriptional regulator
LH95_RS10775	COG0626	cystathionine gamma-synthase activity
LH95_RS10780	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LH95_RS10790	COG2272	Belongs to the type-B carboxylesterase lipase family
LH95_RS10795	COG0733	neurotransmitter:sodium symporter activity
LH95_RS10805	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LH95_RS10810	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LH95_RS10810	COG0574	Belongs to the PEP-utilizing enzyme family
LH95_RS10820	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LH95_RS10835	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LH95_RS10855	COG0456	acetyltransferase
LH95_RS10870	COG1124	(ABC) transporter
LH95_RS10875	COG0444	Belongs to the ABC transporter superfamily
LH95_RS10880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH95_RS10885	COG0601	transmembrane transport
LH95_RS10925	COG3189	MarR family transcriptional regulator
LH95_RS10930	COG2814	Major facilitator Superfamily
LH95_RS10950	COG1683	Conserved Protein
LH95_RS10955	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LH95_RS10960	COG1136	(ABC) transporter
LH95_RS10960	COG0577	efflux transmembrane transporter activity
LH95_RS11015	COG2211	Major facilitator Superfamily
LH95_RS11050	COG5484	DNA packaging
LH95_RS11050	COG3728	DNA packaging
LH95_RS11055	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LH95_RS11055	COG0519	Catalyzes the synthesis of GMP from XMP
LH95_RS11060	COG0516	GMP reductase activity
LH95_RS11060	COG0517	IMP dehydrogenase activity
LH95_RS11065	COG2233	PERMEase
LH95_RS11070	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LH95_RS11085	COG5183	chlorophyll binding
LH95_RS11095	COG1823	symporter activity
LH95_RS11100	COG0778	Nitroreductase
LH95_RS11105	COG0450	alkyl hydroperoxide reductase
LH95_RS11115	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LH95_RS11120	COG5646	InterPro IPR014922
LH95_RS11125	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LH95_RS11130	COG2011	ABC-type metal ion transport system permease component
LH95_RS11135	COG1464	Belongs to the NlpA lipoprotein family
LH95_RS11140	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LH95_RS11145	COG2814	Major facilitator Superfamily
LH95_RS11155	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LH95_RS11165	COG0360	Binds together with S18 to 16S ribosomal RNA
LH95_RS11185	COG0012	GTP binding
LH95_RS11190	COG4481	Protein conserved in bacteria
LH95_RS11195	COG0668	transmembrane transport
LH95_RS11200	COG1475	DNA binding
LH95_RS11205	COG0626	cystathionine gamma-synthase activity
LH95_RS11210	COG0626	cystathionine gamma-synthase activity
LH95_RS11215	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LH95_RS11215	COG0646	methionine synthase
LH95_RS11230	COG0829	nickel cation binding
LH95_RS11240	COG0830	nickel cation binding
LH95_RS11245	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
LH95_RS11250	COG2353	YceI-like domain
LH95_RS11255	COG1846	Transcriptional regulator
LH95_RS11260	COG0346	lactoylglutathione lyase activity
LH95_RS11265	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LH95_RS11270	COG0400	carboxylic ester hydrolase activity
LH95_RS11295	COG1475	DNA binding
LH95_RS11300	COG0357	Ribosomal RNA small subunit methyltransferase G
LH95_RS11305	COG0445	tRNA wobble uridine modification
LH95_RS11310	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LH95_RS11315	COG0594	ribonuclease P activity