locus-tag	class	description
RN70_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RN70_RS00010	COG0592	DNA-directed DNA polymerase activity
RN70_RS00020	COG2501	S4 domain
RN70_RS00030	COG0187	DNA topoisomerase II activity
RN70_RS00040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RN70_RS00045	COG2986	histidine ammonia-lyase
RN70_RS00055	COG2353	YceI-like domain
RN70_RS00060	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
RN70_RS00070	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RN70_RS00075	COG4241	membrane
RN70_RS00080	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
RN70_RS00085	COG0359	binds to the 23S rRNA
RN70_RS00090	COG0305	Participates in initiation and elongation during chromosome replication
RN70_RS00095	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RN70_RS00110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
RN70_RS00130	COG0745	RESPONSE REGULATOR receiver
RN70_RS00135	COG5002	protein histidine kinase activity
RN70_RS00140	COG4863	YycH protein
RN70_RS00150	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RN70_RS00160	COG0747	negative chemotaxis
RN70_RS00180	COG1124	(ABC) transporter
RN70_RS00185	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
RN70_RS00190	COG1397	ADP-ribosylglycohydrolase
RN70_RS00200	COG1105	Belongs to the carbohydrate kinase PfkB family
RN70_RS00215	COG2030	dehydratase
RN70_RS00220	COG0584	glycerophosphoryl diester phosphodiesterase
RN70_RS00235	COG2217	Heavy metal translocating P-type atpase
RN70_RS00240	COG1388	LysM domain
RN70_RS00320	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
RN70_RS00340	COG0464	growth
RN70_RS00355	COG0542	response to heat
RN70_RS00385	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
RN70_RS00395	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
RN70_RS00425	COG2207	Transcriptional regulator
RN70_RS00435	COG2207	Transcriptional regulator
RN70_RS00445	COG2211	Major facilitator Superfamily
RN70_RS00460	COG1136	(ABC) transporter
RN70_RS00465	COG1609	Transcriptional regulator
RN70_RS00470	COG1621	beta-fructofuranosidase activity
RN70_RS00485	COG1250	3-hydroxyacyl-CoA dehydrogenase
RN70_RS00490	COG0415	Belongs to the DNA photolyase family
RN70_RS00505	COG2376	Dihydroxyacetone kinase
RN70_RS00510	COG1461	Dihydroxyacetone kinase
RN70_RS00515	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
RN70_RS00525	COG0577	efflux transmembrane transporter activity
RN70_RS00525	COG0577	efflux transmembrane transporter activity
RN70_RS00530	COG1136	(ABC) transporter
RN70_RS00535	COG2205	protein histidine kinase activity
RN70_RS00540	COG0745	RESPONSE REGULATOR receiver
RN70_RS00560	COG0753	catalase activity
RN70_RS00565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RN70_RS00570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RN70_RS00575	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RN70_RS00585	COG2423	ornithine cyclodeaminase activity
RN70_RS00590	COG4264	IucA IucC family
RN70_RS00595	COG2814	Major facilitator Superfamily
RN70_RS00600	COG4264	IucA IucC family
RN70_RS00605	COG4264	IucA IucC family
RN70_RS00615	COG0019	diaminopimelate decarboxylase activity
RN70_RS00620	COG1475	DNA binding
RN70_RS00625	COG0706	membrane insertase activity
RN70_RS00635	COG1869	D-ribose catabolic process
RN70_RS00640	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RN70_RS00650	COG1288	antiporter activity
RN70_RS00690	COG2197	response regulator
RN70_RS00695	COG4585	Histidine kinase
RN70_RS00700	COG0842	Transport permease protein
RN70_RS00705	COG1131	(ABC) transporter
RN70_RS00755	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
RN70_RS00785	COG1695	Transcriptional regulator
RN70_RS00795	COG3477	response to acidic pH
RN70_RS00810	COG1388	LysM domain
RN70_RS00835	COG3711	transcriptional antiterminator
RN70_RS00850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RN70_RS00870	COG2235	arginine
RN70_RS00875	COG1438	arginine binding
RN70_RS00885	COG4716	Myosin-crossreactive antigen
RN70_RS00890	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RN70_RS00935	COG2188	Transcriptional regulator
RN70_RS00970	COG2388	GCN5-related N-acetyl-transferase
RN70_RS00980	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RN70_RS01000	COG2723	6-phospho-beta-galactosidase activity
RN70_RS01005	COG2188	Transcriptional regulator
RN70_RS01010	COG0492	ferredoxin-NADP+ reductase activity
RN70_RS01015	COG1846	Transcriptional regulator
RN70_RS01035	COG0346	lactoylglutathione lyase activity
RN70_RS01045	COG1012	belongs to the aldehyde dehydrogenase family
RN70_RS01045	COG1454	alcohol dehydrogenase
RN70_RS01050	COG0471	metal ion transport
RN70_RS01055	COG1827	regulation of RNA biosynthetic process
RN70_RS01065	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
RN70_RS01070	COG0157	Belongs to the NadC ModD family
RN70_RS01075	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
RN70_RS01090	COG0366	Alpha amylase catalytic
RN70_RS01095	COG2188	Transcriptional regulator
RN70_RS01100	COG2222	sugar isomerase
RN70_RS01105	COG1105	Belongs to the carbohydrate kinase PfkB family
RN70_RS01110	COG3684	Belongs to the aldolase LacD family
RN70_RS01120	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
RN70_RS01120	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RN70_RS01125	COG3715	PTS system
RN70_RS01130	COG3716	PTS system mannose fructose sorbose family IID component
RN70_RS01140	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RN70_RS01160	COG3314	Sporulation integral membrane protein YlbJ
RN70_RS01165	COG1414	Transcriptional regulator
RN70_RS01170	COG0531	amino acid
RN70_RS01195	COG1063	alcohol dehydrogenase
RN70_RS01200	COG1620	l-lactate permease
RN70_RS01205	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RN70_RS01210	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RN70_RS01235	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
RN70_RS01240	COG2910	NAD(P)H-binding
RN70_RS01245	COG2814	Major facilitator Superfamily
RN70_RS01250	COG1335	isochorismatase
RN70_RS01260	COG1063	alcohol dehydrogenase
RN70_RS01275	COG2318	DinB family
RN70_RS01280	COG0753	catalase activity
RN70_RS01290	COG0783	Belongs to the Dps family
RN70_RS01305	COG0436	Aminotransferase
RN70_RS01325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RN70_RS01340	COG2814	Major facilitator Superfamily
RN70_RS01345	COG2162	N-hydroxyarylamine O-acetyltransferase activity
RN70_RS01355	COG1335	isochorismatase
RN70_RS01420	COG3682	Transcriptional regulator
RN70_RS01470	COG0456	acetyltransferase
RN70_RS01505	COG0431	NADPH-dependent FMN reductase
RN70_RS01515	COG4932	domain protein
RN70_RS01520	COG0456	acetyltransferase
RN70_RS01525	COG1755	Isoprenylcysteine carboxyl methyltransferase
RN70_RS01535	COG0579	oxidoreductase
RN70_RS01570	COG1073	alpha beta
RN70_RS01590	COG0438	transferase activity, transferring glycosyl groups
RN70_RS01595	COG0183	Belongs to the thiolase family
RN70_RS01600	COG1250	3-hydroxyacyl-CoA dehydrogenase
RN70_RS01600	COG1024	Enoyl-CoA hydratase
RN70_RS01605	COG1960	acyl-CoA dehydrogenase activity
RN70_RS01610	COG0318	PFAM AMP-dependent synthetase and ligase
RN70_RS01625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RN70_RS01635	COG1116	anion transmembrane transporter activity
RN70_RS01645	COG0563	adenylate kinase activity
RN70_RS01655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RN70_RS01680	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RN70_RS01680	COG3711	transcriptional antiterminator
RN70_RS01685	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RN70_RS01695	COG3037	sugar-specific permease SgaT UlaA
RN70_RS01700	COG1328	CTP reductase activity
RN70_RS01705	COG0602	queuosine metabolic process
RN70_RS01720	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RN70_RS01725	COG1942	4-Oxalocrotonate Tautomerase
RN70_RS01740	COG3443	Belongs to the bacterial solute-binding protein 9 family
RN70_RS01740	COG0803	Belongs to the bacterial solute-binding protein 9 family
RN70_RS01750	COG3527	Alpha-acetolactate decarboxylase
RN70_RS01765	COG4753	response regulator
RN70_RS01765	COG2207	Transcriptional regulator
RN70_RS01780	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
RN70_RS01785	COG1210	Utp--glucose-1-phosphate uridylyltransferase
RN70_RS01790	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
RN70_RS01795	COG2211	Major facilitator Superfamily
RN70_RS01800	COG1957	nucleoside hydrolase
RN70_RS01810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RN70_RS01815	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
RN70_RS01820	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
RN70_RS01825	COG2807	transmembrane transport
RN70_RS01830	COG1476	TRANSCRIPTIONal
RN70_RS01835	COG0586	Pfam SNARE associated Golgi protein
RN70_RS01850	COG1510	regulation of RNA biosynthetic process
RN70_RS01855	COG1012	belongs to the aldehyde dehydrogenase family
RN70_RS01860	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
RN70_RS01875	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RN70_RS01880	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RN70_RS01885	COG0131	Imidazoleglycerol-phosphate dehydratase
RN70_RS01890	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RN70_RS01900	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
RN70_RS01905	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
RN70_RS01940	COG2376	Dihydroxyacetone kinase
RN70_RS01945	COG1461	Dihydroxyacetone kinase
RN70_RS01955	COG2824	Alkylphosphonate utilization operon protein PhnA
RN70_RS01960	COG1012	belongs to the aldehyde dehydrogenase family
RN70_RS01970	COG0596	Alpha beta hydrolase
RN70_RS01980	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RN70_RS01980	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RN70_RS01980	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RN70_RS01995	COG1705	Flagellar rod assembly protein muramidase FlgJ
RN70_RS01995	COG3942	CHAP domain
RN70_RS02005	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RN70_RS02020	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RN70_RS02025	COG0747	negative chemotaxis
RN70_RS02050	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
RN70_RS02050	COG0463	Glycosyl transferase, family 2
RN70_RS02055	COG0438	transferase activity, transferring glycosyl groups
RN70_RS02070	COG3181	Tripartite tricarboxylate transporter family receptor
RN70_RS02075	COG0778	Nitroreductase
RN70_RS02080	COG3001	Fructosamine kinase
RN70_RS02100	COG1136	(ABC) transporter
RN70_RS02105	COG0577	efflux transmembrane transporter activity
RN70_RS02110	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
RN70_RS02120	COG4413	Urea transporter
RN70_RS02125	COG0831	urea catabolic process
RN70_RS02130	COG0832	Belongs to the urease beta subunit family
RN70_RS02135	COG0804	urea catabolic process
RN70_RS02140	COG0717	Belongs to the dCTP deaminase family
RN70_RS02145	COG0523	cobalamin synthesis protein
RN70_RS02160	COG0583	DNA-binding transcription factor activity
RN70_RS02170	COG1346	cytolysis
RN70_RS02175	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RN70_RS02180	COG4605	iron ion homeostasis
RN70_RS02185	COG4604	ABC transporter, ATP-binding protein
RN70_RS02190	COG4607	ABC-type enterochelin transport system periplasmic component
RN70_RS02205	COG0778	Nitroreductase
RN70_RS02220	COG3942	CHAP domain
RN70_RS02235	COG0596	Alpha beta hydrolase
RN70_RS02260	COG1028	Short-chain dehydrogenase reductase Sdr
RN70_RS02270	COG2816	NAD+ diphosphatase activity
RN70_RS02280	COG3835	regulator
RN70_RS02290	COG3961	Belongs to the TPP enzyme family
RN70_RS02295	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RN70_RS02300	COG0512	Glutamine amidotransferase of anthranilate synthase
RN70_RS02310	COG0134	indole-3-glycerol-phosphate synthase activity
RN70_RS02315	COG0135	phosphoribosylanthranilate isomerase activity
RN70_RS02320	COG0133	tryptophan synthase activity
RN70_RS02325	COG0159	tryptophan synthase activity
RN70_RS02340	COG1132	(ABC) transporter
RN70_RS02345	COG1132	(ABC) transporter
RN70_RS02355	COG1115	amino acid carrier protein
RN70_RS02360	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
RN70_RS02365	COG2814	Major facilitator Superfamily
RN70_RS02370	COG2271	Major facilitator Superfamily
RN70_RS02375	COG3764	Sortase (surface protein transpeptidase)
RN70_RS02380	COG1929	Belongs to the glycerate kinase type-1 family
RN70_RS02385	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
RN70_RS02395	COG1174	glycine betaine transport
RN70_RS02420	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RN70_RS02430	COG0702	epimerase
RN70_RS02445	COG1760	l-serine dehydratase
RN70_RS02450	COG1760	l-serine dehydratase
RN70_RS02495	COG0454	-acetyltransferase
RN70_RS02510	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RN70_RS02515	COG2146	nitrite reductase [NAD(P)H] activity
RN70_RS02520	COG1648	precorrin-2 dehydrogenase activity
RN70_RS02520	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RN70_RS02525	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
RN70_RS02530	COG1140	nitrate reductase beta subunit
RN70_RS02540	COG2181	nitrate reductase activity
RN70_RS02550	COG4585	Histidine kinase
RN70_RS02555	COG2197	response regulator
RN70_RS02565	COG2223	nitrite transmembrane transporter activity
RN70_RS02575	COG0039	L-malate dehydrogenase activity
RN70_RS02580	COG1363	Peptidase, m42
RN70_RS02595	COG2807	transmembrane transport
RN70_RS02615	COG1283	sodium-dependent phosphate transmembrane transporter activity
RN70_RS02635	COG0456	acetyltransferase
RN70_RS02640	COG2814	Major facilitator Superfamily
RN70_RS02645	COG0604	alcohol dehydrogenase
RN70_RS02655	COG1620	l-lactate permease
RN70_RS02665	COG0438	transferase activity, transferring glycosyl groups
RN70_RS02715	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
RN70_RS02725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RN70_RS02745	COG1304	FMN binding
RN70_RS02750	COG0523	cobalamin synthesis protein
RN70_RS02755	COG0786	glutamate:sodium symporter activity
RN70_RS02760	COG2207	Transcriptional regulator
RN70_RS02770	COG1695	Transcriptional regulator
RN70_RS02785	COG1757	Na H antiporter
RN70_RS02790	COG2094	Belongs to the DNA glycosylase MPG family
RN70_RS02800	COG1288	antiporter activity
RN70_RS02805	COG4152	abc transporter atp-binding protein
RN70_RS02810	COG1668	transmembrane transport
RN70_RS02815	COG1742	UPF0060 membrane protein
RN70_RS02820	COG2017	converts alpha-aldose to the beta-anomer
RN70_RS02825	COG1476	TRANSCRIPTIONal
RN70_RS02830	COG2258	MOSC domain
RN70_RS02835	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
RN70_RS02840	COG1266	CAAX protease self-immunity
RN70_RS02845	COG0010	Belongs to the arginase family
RN70_RS02850	COG0583	DNA-binding transcription factor activity
RN70_RS02855	COG3314	Sporulation integral membrane protein YlbJ
RN70_RS02865	COG1228	amidohydrolase
RN70_RS02870	COG0659	secondary active sulfate transmembrane transporter activity
RN70_RS02875	COG1473	amidohydrolase
RN70_RS02895	COG0385	Bile acid
RN70_RS02925	COG1113	amino acid transport
RN70_RS02950	COG1316	TRANSCRIPTIONal
RN70_RS02965	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
RN70_RS02970	COG3383	formate dehydrogenase (NAD+) activity
RN70_RS02995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RN70_RS03000	COG2076	Multidrug Resistance protein
RN70_RS03005	COG2076	Multidrug Resistance protein
RN70_RS03020	COG1757	Na H antiporter
RN70_RS03030	COG3942	CHAP domain
RN70_RS03050	COG1960	acyl-CoA dehydrogenase activity
RN70_RS03055	COG2832	Protein of unknown function (DUF454)
RN70_RS03060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RN70_RS03065	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RN70_RS03075	COG2186	Transcriptional regulator
RN70_RS03080	COG1940	carbohydrate kinase activity
RN70_RS03085	COG1268	BioY protein
RN70_RS03100	COG1609	Transcriptional regulator
RN70_RS03105	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
RN70_RS03110	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RN70_RS03115	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
RN70_RS03120	COG0725	ABC transporter, periplasmic molybdate-binding protein
RN70_RS03125	COG4149	molybdate abc transporter
RN70_RS03130	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
RN70_RS03135	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RN70_RS03140	COG0521	Mo-molybdopterin cofactor biosynthetic process
RN70_RS03145	COG0315	cyclic pyranopterin monophosphate synthase activity
RN70_RS03160	COG0314	molybdopterin synthase activity
RN70_RS03170	COG0746	molybdenum cofactor guanylyltransferase activity
RN70_RS03175	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RN70_RS03200	COG2348	transferase activity, transferring amino-acyl groups
RN70_RS03205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RN70_RS03210	COG0436	Aminotransferase
RN70_RS03235	COG2252	PERMEase
RN70_RS03250	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RN70_RS03255	COG0088	Forms part of the polypeptide exit tunnel
RN70_RS03260	COG0089	rRNA binding
RN70_RS03265	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RN70_RS03270	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RN70_RS03275	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RN70_RS03280	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RN70_RS03290	COG0255	Belongs to the universal ribosomal protein uL29 family
RN70_RS03300	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RN70_RS03305	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RN70_RS03310	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RN70_RS03315	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RN70_RS03320	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RN70_RS03340	COG1841	ribosomal large subunit assembly
RN70_RS03350	COG0201	protein transport
RN70_RS03365	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RN70_RS03375	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RN70_RS03380	COG0202	RNA polymerase activity
RN70_RS03385	COG0203	ribosomal protein L17
RN70_RS03390	COG1122	ATPase activity
RN70_RS03395	COG1122	ATPase activity
RN70_RS03405	COG0101	tRNA pseudouridine synthase activity
RN70_RS03415	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RN70_RS03450	COG0018	arginyl-trna synthetase
RN70_RS03460	COG0789	Transcriptional regulator
RN70_RS03465	COG1335	isochorismatase
RN70_RS03470	COG0488	(ABC) transporter
RN70_RS03475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RN70_RS03480	COG0604	alcohol dehydrogenase
RN70_RS03485	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RN70_RS03500	COG1302	Protein conserved in bacteria
RN70_RS03505	COG2814	Major facilitator Superfamily
RN70_RS03510	COG4264	IucA IucC family
RN70_RS03515	COG2814	Major facilitator Superfamily
RN70_RS03520	COG4264	IucA IucC family
RN70_RS03525	COG3457	Alanine racemase
RN70_RS03530	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
RN70_RS03535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RN70_RS03540	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RN70_RS03545	COG3314	Sporulation integral membrane protein YlbJ
RN70_RS03555	COG1988	membrane-bound metal-dependent
RN70_RS03560	COG4284	Utp--glucose-1-phosphate uridylyltransferase
RN70_RS03565	COG1272	protein, Hemolysin III
RN70_RS03585	COG2814	Major facilitator Superfamily
RN70_RS03590	COG0489	protein tyrosine kinase activity
RN70_RS03655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RN70_RS03675	COG2186	Transcriptional regulator
RN70_RS03680	COG1482	cell wall glycoprotein biosynthetic process
RN70_RS03705	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
RN70_RS03735	COG5146	pantothenate kinase activity
RN70_RS03745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RN70_RS03760	COG2271	Major facilitator Superfamily
RN70_RS03765	COG4821	SIS domain
RN70_RS03770	COG0191	fructose-bisphosphate aldolase activity
RN70_RS03775	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RN70_RS03780	COG1733	regulation of RNA biosynthetic process
RN70_RS03790	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RN70_RS03795	COG0254	rRNA binding
RN70_RS03805	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RN70_RS03810	COG2890	protein-(glutamine-N5) methyltransferase activity
RN70_RS03815	COG0009	L-threonylcarbamoyladenylate synthase
RN70_RS03820	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RN70_RS03825	COG4475	Protein of unknown function (DUF436)
RN70_RS03830	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RN70_RS03835	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RN70_RS03840	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
RN70_RS03850	COG0356	it plays a direct role in the translocation of protons across the membrane
RN70_RS03855	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RN70_RS03865	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RN70_RS03870	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RN70_RS03875	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RN70_RS03895	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RN70_RS03905	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RN70_RS03920	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
RN70_RS03930	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
RN70_RS03935	COG0352	thiamine-phosphate diphosphorylase activity
RN70_RS03940	COG0706	membrane insertase activity
RN70_RS03955	COG1418	mRNA catabolic process
RN70_RS03965	COG1937	Protein conserved in bacteria
RN70_RS03980	COG2217	Heavy metal translocating P-type atpase
RN70_RS03985	COG0772	Belongs to the SEDS family
RN70_RS03990	COG1181	Belongs to the D-alanine--D-alanine ligase family
RN70_RS03995	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RN70_RS04000	COG0513	Belongs to the DEAD box helicase family
RN70_RS04020	COG0736	holo-[acyl-carrier-protein] synthase activity
RN70_RS04025	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RN70_RS04035	COG2337	Toxic component of a toxin-antitoxin (TA) module
RN70_RS04040	COG2208	phosphoserine phosphatase activity
RN70_RS04045	COG1366	Belongs to the anti-sigma-factor antagonist family
RN70_RS04055	COG1191	sigma factor activity
RN70_RS04060	COG2183	response to ionizing radiation
RN70_RS04065	COG3091	SprT-like family
RN70_RS04095	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RN70_RS04105	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RN70_RS04115	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RN70_RS04130	COG0028	Belongs to the TPP enzyme family
RN70_RS04135	COG0129	dihydroxy-acid dehydratase activity
RN70_RS04140	COG0802	atpase or kinase
RN70_RS04145	COG1214	PFAM Peptidase M22, glycoprotease
RN70_RS04150	COG0456	acetyltransferase
RN70_RS04155	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RN70_RS04160	COG0488	(ABC) transporter
RN70_RS04165	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
RN70_RS04170	COG2391	methyltransferase activity
RN70_RS04175	COG0425	Belongs to the sulfur carrier protein TusA family
RN70_RS04180	COG1621	beta-fructofuranosidase activity
RN70_RS04200	COG4512	PFAM Accessory gene regulator B
RN70_RS04260	COG1464	Belongs to the NlpA lipoprotein family
RN70_RS04265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RN70_RS04285	COG1131	(ABC) transporter
RN70_RS04295	COG1802	Transcriptional regulator
RN70_RS04300	COG1070	Carbohydrate kinase
RN70_RS04305	COG2610	gluconate transmembrane transporter activity
RN70_RS04340	COG2706	6-phosphogluconolactonase activity
RN70_RS04345	COG1012	belongs to the aldehyde dehydrogenase family
RN70_RS04355	COG1227	inorganic diphosphatase activity
RN70_RS04360	COG1335	isochorismatase
RN70_RS04370	COG0077	Prephenate dehydratase
RN70_RS04380	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
RN70_RS04385	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
RN70_RS04390	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
RN70_RS04395	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RN70_RS04400	COG4496	protein, YerC YecD
RN70_RS04405	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
RN70_RS04410	COG0210	DNA helicase
RN70_RS04415	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RN70_RS04420	COG4851	CamS sex pheromone cAM373 precursor
RN70_RS04425	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RN70_RS04430	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RN70_RS04435	COG0154	amidase activity
RN70_RS04440	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RN70_RS04450	COG1597	lipid kinase activity
RN70_RS04455	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RN70_RS04470	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RN70_RS04480	COG1528	Iron-storage protein
RN70_RS04495	COG4129	membrane
RN70_RS04500	COG0024	Methionine aminopeptidase
RN70_RS04525	COG0288	reversible hydration of carbon dioxide
RN70_RS04530	COG1295	ribonuclease BN
RN70_RS04540	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RN70_RS04545	COG4840	Belongs to the UPF0435 family
RN70_RS04550	COG2309	aminopeptidase activity
RN70_RS04555	COG1607	acyl-coa hydrolase
RN70_RS04560	COG0535	radical SAM domain protein
RN70_RS04565	COG0693	protein deglycase activity
RN70_RS04570	COG0028	Belongs to the TPP enzyme family
RN70_RS04575	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RN70_RS04590	COG1134	teichoic acid transport
RN70_RS04590	COG1388	LysM domain
RN70_RS04600	COG1988	membrane-bound metal-dependent
RN70_RS04620	COG0069	glutamate synthase activity
RN70_RS04625	COG4129	membrane
RN70_RS04630	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RN70_RS04635	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RN70_RS04645	COG0735	belongs to the Fur family
RN70_RS04805	COG0765	amino acid transport
RN70_RS04810	COG1126	abc transporter atp-binding protein
RN70_RS04815	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RN70_RS04825	COG0363	glucosamine-6-phosphate deaminase activity
RN70_RS04835	COG0114	fumarate hydratase activity
RN70_RS04840	COG0248	Ppx GppA phosphatase
RN70_RS04845	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
RN70_RS04850	COG0564	pseudouridine synthase activity
RN70_RS04855	COG2203	Gaf domain
RN70_RS04855	COG4585	Histidine kinase
RN70_RS04860	COG2197	response regulator
RN70_RS04865	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
RN70_RS04870	COG1301	dicarboxylic acid transport
RN70_RS04890	COG4399	Belongs to the UPF0754 family
RN70_RS04895	COG3679	Belongs to the UPF0342 family
RN70_RS04900	COG0420	3'-5' exonuclease activity
RN70_RS04910	COG3481	metal-dependent phosphohydrolase, HD sub domain
RN70_RS04915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RN70_RS04925	COG1846	Transcriptional regulator
RN70_RS04935	COG0537	adenosine 5'-monophosphoramidase activity
RN70_RS04940	COG1131	(ABC) transporter
RN70_RS04945	COG4473	ABC transporter
RN70_RS04955	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
RN70_RS04960	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
RN70_RS04965	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
RN70_RS04970	COG3545	Serine hydrolase
RN70_RS05065	COG0076	glutamate decarboxylase activity
RN70_RS05085	COG0318	PFAM AMP-dependent synthetase and ligase
RN70_RS05095	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
RN70_RS05105	COG1506	peptidase
RN70_RS05110	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
RN70_RS05115	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RN70_RS05125	COG0656	L-ascorbic acid biosynthetic process
RN70_RS05130	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RN70_RS05145	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RN70_RS05170	COG3266	domain, Protein
RN70_RS05170	COG4193	domain, Protein
RN70_RS05170	COG5632	N-Acetylmuramoyl-L-alanine amidase
RN70_RS05185	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RN70_RS05185	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RN70_RS05195	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RN70_RS05195	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RN70_RS05200	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RN70_RS05205	COG0506	proline dehydrogenase activity
RN70_RS05215	COG2267	carboxylic ester hydrolase activity
RN70_RS05220	COG0039	L-malate dehydrogenase activity
RN70_RS05230	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
RN70_RS05235	COG1242	4 iron, 4 sulfur cluster binding
RN70_RS05240	COG2814	Major facilitator Superfamily
RN70_RS05245	COG0495	leucyl-tRNA aminoacylation
RN70_RS05250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RN70_RS05255	COG2081	HI0933 family
RN70_RS05260	COG2244	polysaccharide biosynthetic process
RN70_RS05265	COG1187	pseudouridine synthase activity
RN70_RS05275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RN70_RS05280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RN70_RS05285	COG0510	thiamine kinase activity
RN70_RS05290	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RN70_RS05295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RN70_RS05305	COG1363	Peptidase, m42
RN70_RS05310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RN70_RS05320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RN70_RS05325	COG1674	ftsk spoiiie
RN70_RS05330	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RN70_RS05335	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
RN70_RS05345	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
RN70_RS05345	COG1605	Chorismate mutase
RN70_RS05350	COG1609	Transcriptional regulator
RN70_RS05360	COG0454	-acetyltransferase
RN70_RS05365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RN70_RS05370	COG2759	Belongs to the formate--tetrahydrofolate ligase family
RN70_RS05375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RN70_RS05385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RN70_RS05390	COG0204	Acyl-transferase
RN70_RS05400	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RN70_RS05405	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
RN70_RS05410	COG1764	response to oxidative stress
RN70_RS05415	COG0584	glycerophosphoryl diester phosphodiesterase
RN70_RS05425	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RN70_RS05430	COG1956	GAF domain-containing protein
RN70_RS05435	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
RN70_RS05440	COG1104	cysteine desulfurase activity
RN70_RS05445	COG0301	tRNA thio-modification
RN70_RS05455	COG0616	signal peptide processing
RN70_RS05465	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
RN70_RS05470	COG0827	DNA restriction-modification system
RN70_RS05475	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RN70_RS05480	COG0589	response to stress
RN70_RS05485	COG0686	Belongs to the AlaDH PNT family
RN70_RS05495	COG0006	proline dipeptidase activity
RN70_RS05500	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
RN70_RS05510	COG4109	DRTGG domain
RN70_RS05515	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
RN70_RS05525	COG0281	malic enzyme
RN70_RS05530	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RN70_RS05535	COG0825	malonyl-CoA metabolic process
RN70_RS05540	COG0205	6-phosphofructokinase activity
RN70_RS05545	COG0469	pyruvate kinase activity
RN70_RS05550	COG0372	Belongs to the citrate synthase family
RN70_RS05555	COG0538	isocitrate dehydrogenase activity
RN70_RS05560	COG0745	RESPONSE REGULATOR receiver
RN70_RS05565	COG5002	protein histidine kinase activity
RN70_RS05570	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RN70_RS05570	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RN70_RS05575	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RN70_RS05580	COG0237	dephospho-CoA kinase activity
RN70_RS05585	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RN70_RS05590	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RN70_RS05595	COG3611	Membrane attachment protein
RN70_RS05600	COG1484	DNA-dependent DNA replication
RN70_RS05610	COG0833	amino acid
RN70_RS05615	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RN70_RS05620	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RN70_RS05630	COG4112	unkown
RN70_RS05640	COG0544	peptidyl-prolyl cis-trans isomerase activity
RN70_RS05645	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RN70_RS05650	COG0218	Necessary for normal cell division and for the maintenance of normal septation
RN70_RS05655	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
RN70_RS05660	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RN70_RS05665	COG0181	hydroxymethylbilane synthase activity
RN70_RS05675	COG0113	porphobilinogen synthase activity
RN70_RS05680	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RN70_RS05690	COG2818	Glycosylase
RN70_RS05695	COG0525	valine-tRNA ligase activity
RN70_RS05700	COG0285	dihydrofolate synthase activity
RN70_RS05710	COG2003	Belongs to the UPF0758 family
RN70_RS05730	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RN70_RS05735	COG2868	ribosomal protein
RN70_RS05750	COG4492	Belongs to the UPF0735 family
RN70_RS05755	COG0632	four-way junction helicase activity
RN70_RS05760	COG2255	four-way junction helicase activity
RN70_RS05765	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RN70_RS05775	COG1862	Preprotein translocase
RN70_RS05780	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RN70_RS05780	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RN70_RS05785	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RN70_RS05785	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
RN70_RS05790	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RN70_RS05800	COG1490	D-aminoacyl-tRNA deacylase activity
RN70_RS05805	COG0860	N-Acetylmuramoyl-L-alanine amidase
RN70_RS05820	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
RN70_RS05825	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RN70_RS05830	COG1959	2 iron, 2 sulfur cluster binding
RN70_RS05845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RN70_RS05850	COG1104	cysteine desulfurase activity
RN70_RS05855	COG0482	sulfurtransferase activity
RN70_RS05865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RN70_RS05870	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RN70_RS05875	COG4472	Bacterial protein of unknown function (DUF965)
RN70_RS05880	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RN70_RS05885	COG3906	Belongs to the UPF0473 family
RN70_RS05890	COG4122	O-methyltransferase activity
RN70_RS05895	COG0826	peptidase U32
RN70_RS05900	COG0826	peptidase U32
RN70_RS05905	COG0572	uridine kinase
RN70_RS05915	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RN70_RS05920	COG1984	allophanate hydrolase subunit 2
RN70_RS05925	COG0511	ligase activity, forming carbon-carbon bonds
RN70_RS05930	COG0439	Biotin carboxylase
RN70_RS05935	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
RN70_RS05940	COG1914	H( )-stimulated, divalent metal cation uptake system
RN70_RS05950	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RN70_RS05955	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
RN70_RS05960	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
RN70_RS05965	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RN70_RS05970	COG1534	Rna-binding protein
RN70_RS05980	COG1713	HD superfamily hydrolase involved in NAD metabolism
RN70_RS05985	COG0799	negative regulation of ribosome biogenesis
RN70_RS05990	COG2226	methyltransferase
RN70_RS05995	COG1555	photosystem II stabilization
RN70_RS05995	COG1596	polysaccharide export
RN70_RS06000	COG2131	deaminase
RN70_RS06010	COG1466	dna polymerase III delta subunit
RN70_RS06015	COG0268	Binds directly to 16S ribosomal RNA
RN70_RS06025	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RN70_RS06030	COG1420	regulation of RNA biosynthetic process
RN70_RS06045	COG0484	heat shock protein binding
RN70_RS06050	COG2264	protein methyltransferase activity
RN70_RS06055	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RN70_RS06060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RN70_RS06075	COG4864	UPF0365 protein
RN70_RS06085	COG1702	phosphate starvation-inducible protein PhoH
RN70_RS06090	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RN70_RS06095	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
RN70_RS06100	COG0295	cytidine deaminase activity
RN70_RS06110	COG1381	Involved in DNA repair and RecF pathway recombination
RN70_RS06115	COG0423	glycine-tRNA ligase activity
RN70_RS06120	COG0517	IMP dehydrogenase activity
RN70_RS06125	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
RN70_RS06130	COG0358	DNA primase activity
RN70_RS06135	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RN70_RS06140	COG2384	SAM-dependent methyltransferase
RN70_RS06150	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RN70_RS06155	COG0513	Belongs to the DEAD box helicase family
RN70_RS06160	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
RN70_RS06165	COG1121	(ABC) transporter
RN70_RS06170	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RN70_RS06175	COG0735	belongs to the Fur family
RN70_RS06180	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RN70_RS06195	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RN70_RS06200	COG0573	inorganic phosphate transmembrane transporter activity
RN70_RS06205	COG0581	inorganic phosphate transmembrane transporter activity
RN70_RS06210	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RN70_RS06215	COG0704	Plays a role in the regulation of phosphate uptake
RN70_RS06220	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RN70_RS06225	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RN70_RS06230	COG0705	Rhomboid family
RN70_RS06230	COG0457	Tetratricopeptide repeat
RN70_RS06235	COG4483	Protein conserved in bacteria
RN70_RS06240	COG1940	carbohydrate kinase activity
RN70_RS06245	COG0011	TIGRFAM Protein of
RN70_RS06250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RN70_RS06255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RN70_RS06260	COG1459	type II secretion system
RN70_RS06280	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RN70_RS06285	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RN70_RS06295	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RN70_RS06300	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RN70_RS06305	COG0095	Lipoate-protein ligase
RN70_RS06320	COG0006	proline dipeptidase activity
RN70_RS06325	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RN70_RS06330	COG0511	ligase activity, forming carbon-carbon bonds
RN70_RS06335	COG0439	Biotin carboxylase
RN70_RS06340	COG1302	Protein conserved in bacteria
RN70_RS06360	COG0142	geranyltranstransferase activity
RN70_RS06365	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RN70_RS06370	COG1438	arginine binding
RN70_RS06375	COG0497	DNA recombination
RN70_RS06380	COG0280	phosphate acetyltransferase
RN70_RS06385	COG3426	butyrate kinase activity
RN70_RS06390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RN70_RS06395	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RN70_RS06400	COG0022	dehydrogenase e1 component
RN70_RS06405	COG0508	dehydrogenase complex catalyzes the overall conversion of
RN70_RS06415	COG4129	membrane
RN70_RS06420	COG2195	Cleaves the N-terminal amino acid of tripeptides
RN70_RS06435	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RN70_RS06440	COG1234	tRNA 3'-trailer cleavage
RN70_RS06445	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
RN70_RS06455	COG0667	Aldo Keto reductase
RN70_RS06460	COG0494	nUDIX hydrolase
RN70_RS06465	COG0735	belongs to the Fur family
RN70_RS06480	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
RN70_RS06485	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RN70_RS06490	COG1187	pseudouridine synthase activity
RN70_RS06495	COG0745	RESPONSE REGULATOR receiver
RN70_RS06500	COG5002	protein histidine kinase activity
RN70_RS06510	COG1141	Ferredoxin
RN70_RS06530	COG0492	ferredoxin-NADP+ reductase activity
RN70_RS06540	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RN70_RS06545	COG0539	negative regulation of cytoplasmic translation
RN70_RS06570	COG2226	methyltransferase
RN70_RS06575	COG0142	geranyltranstransferase activity
RN70_RS06580	COG0105	UTP biosynthetic process
RN70_RS06590	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RN70_RS06600	COG0457	Tetratricopeptide repeat
RN70_RS06605	COG5582	Belongs to the UPF0302 family
RN70_RS06610	COG4347	Protein of unknown function (DUF1405)
RN70_RS06615	COG2738	Putative neutral zinc metallopeptidase
RN70_RS06620	COG1694	Mazg nucleotide pyrophosphohydrolase
RN70_RS06625	COG0438	transferase activity, transferring glycosyl groups
RN70_RS06640	COG1199	ATP-dependent helicase activity
RN70_RS06640	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RN70_RS06645	COG0017	Asparaginyl-tRNA synthetase
RN70_RS06650	COG3935	DnaD domain protein
RN70_RS06655	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RN70_RS06665	COG4499	WXG100 protein secretion system (Wss), protein YukC
RN70_RS06665	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RN70_RS06670	COG3331	DNA recombination
RN70_RS06680	COG4474	Belongs to the UPF0398 family
RN70_RS06685	COG3599	regulation of cell shape
RN70_RS06690	COG0116	Belongs to the methyltransferase superfamily
RN70_RS06695	COG2962	Rard protein
RN70_RS06700	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
RN70_RS06705	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RN70_RS06715	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
RN70_RS06725	COG1413	lyase activity
RN70_RS06735	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RN70_RS06760	COG2190	(PTS) system
RN70_RS06765	COG4479	Belongs to the UPF0346 family
RN70_RS06770	COG0793	Belongs to the peptidase S41A family
RN70_RS06780	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RN70_RS06785	COG0671	phosphoesterase, PA-phosphatase related
RN70_RS06795	COG5002	protein histidine kinase activity
RN70_RS06800	COG0567	Dehydrogenase, E1 component
RN70_RS06825	COG0714	Associated with various cellular activities
RN70_RS06830	COG4548	von Willebrand factor, type A
RN70_RS06835	COG1114	Component of the transport system for branched-chain amino acids
RN70_RS06840	COG3853	Toxic anion resistance protein (TelA)
RN70_RS06850	COG1254	Belongs to the acylphosphatase family
RN70_RS06860	COG1278	Cold shock
RN70_RS06875	COG1473	amidohydrolase
RN70_RS06880	COG2171	N-acyltransferase activity
RN70_RS06885	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RN70_RS06890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RN70_RS06895	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RN70_RS06900	COG0488	(ABC) transporter
RN70_RS06905	COG2996	Protein conserved in bacteria
RN70_RS06910	COG3711	transcriptional antiterminator
RN70_RS06915	COG1447	Phosphotransferase system cellobiose-specific component IIA
RN70_RS06920	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RN70_RS06920	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RN70_RS07065	COG0756	dUTP diphosphatase activity
RN70_RS07115	COG4695	Portal protein
RN70_RS07160	COG0739	heme binding
RN70_RS07190	COG1388	LysM domain
RN70_RS07190	COG0860	N-Acetylmuramoyl-L-alanine amidase
RN70_RS07220	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RN70_RS07220	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
RN70_RS07225	COG2723	6-phospho-beta-galactosidase activity
RN70_RS07235	COG0698	ribose 5-phosphate isomerase
RN70_RS07240	COG0698	ribose 5-phosphate isomerase
RN70_RS07270	COG1363	Peptidase, m42
RN70_RS07280	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RN70_RS07310	COG0628	permease
RN70_RS07320	COG3711	transcriptional antiterminator
RN70_RS07325	COG1115	amino acid carrier protein
RN70_RS07335	COG0187	DNA topoisomerase II activity
RN70_RS07340	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RN70_RS07345	COG4841	protein insertion into membrane
RN70_RS07350	COG0824	Thioesterase
RN70_RS07355	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RN70_RS07360	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RN70_RS07365	COG1970	mechanosensitive ion channel activity
RN70_RS07380	COG4846	Membrane protein involved in cytochrome C biogenesis
RN70_RS07390	COG3763	UPF0154 protein
RN70_RS07400	COG4224	UPF0291 protein
RN70_RS07410	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RN70_RS07420	COG0516	GMP reductase activity
RN70_RS07435	COG0833	amino acid
RN70_RS07445	COG0561	phosphatase activity
RN70_RS07450	COG0083	homoserine kinase activity
RN70_RS07455	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
RN70_RS07460	COG0460	homoserine dehydrogenase
RN70_RS07465	COG0527	aspartate kinase activity
RN70_RS07495	COG1518	maintenance of DNA repeat elements
RN70_RS07520	COG2946	Replication initiation factor
RN70_RS07540	COG0433	COG0433 Predicted ATPase
RN70_RS07545	COG1674	ftsk spoiiie
RN70_RS07585	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RN70_RS07590	COG1525	nuclease
RN70_RS07620	COG0584	glycerophosphoryl diester phosphodiesterase
RN70_RS07690	COG0789	Transcriptional regulator
RN70_RS07695	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
RN70_RS07700	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RN70_RS07705	COG0386	Belongs to the glutathione peroxidase family
RN70_RS07710	COG1923	regulation of RNA biosynthetic process
RN70_RS07715	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RN70_RS07720	COG2267	carboxylic ester hydrolase activity
RN70_RS07725	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
RN70_RS07735	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RN70_RS07745	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
RN70_RS07750	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RN70_RS07755	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RN70_RS07770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RN70_RS07780	COG1013	pyruvate-flavodoxin oxidoreductase activity
RN70_RS07785	COG0674	pyruvate-flavodoxin oxidoreductase activity
RN70_RS07785	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
RN70_RS07790	COG1692	metallophosphoesterase
RN70_RS07815	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RN70_RS07820	COG1058	Belongs to the CinA family
RN70_RS07820	COG1546	Belongs to the CinA family
RN70_RS07840	COG1028	Short-chain dehydrogenase reductase Sdr
RN70_RS07845	COG0612	Peptidase, M16
RN70_RS07850	COG0612	Peptidase, M16
RN70_RS07855	COG2188	Transcriptional regulator
RN70_RS07875	COG1185	polyribonucleotide nucleotidyltransferase activity
RN70_RS07885	COG0196	riboflavin kinase activity
RN70_RS07890	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RN70_RS07895	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RN70_RS07900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RN70_RS07910	COG1131	(ABC) transporter
RN70_RS07915	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RN70_RS07960	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RN70_RS07965	COG1358	cellular component organization or biogenesis
RN70_RS07970	COG2740	Nucleic-acid-binding protein implicated in transcription termination
RN70_RS07975	COG0195	Participates in both transcription termination and antitermination
RN70_RS07980	COG0779	Required for maturation of 30S ribosomal subunits
RN70_RS07990	COG0442	prolyl-tRNA aminoacylation
RN70_RS08000	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RN70_RS08005	COG4589	Belongs to the CDS family
RN70_RS08015	COG0233	cytoplasmic translational termination
RN70_RS08020	COG0528	UMP kinase activity
RN70_RS08025	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RN70_RS08030	COG0052	Belongs to the universal ribosomal protein uS2 family
RN70_RS08035	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
RN70_RS08040	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
RN70_RS08045	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
RN70_RS08050	COG4974	Belongs to the 'phage' integrase family
RN70_RS08055	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
RN70_RS08060	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RN70_RS08065	COG0758	DNA mediated transformation
RN70_RS08075	COG0045	succinate-CoA ligase (ADP-forming) activity
RN70_RS08090	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RN70_RS08105	COG4485	Bacterial membrane protein, YfhO
RN70_RS08115	COG0335	large ribosomal subunit rRNA binding
RN70_RS08120	COG0336	Belongs to the RNA methyltransferase TrmD family
RN70_RS08130	COG0228	four-way junction DNA binding
RN70_RS08135	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RN70_RS08140	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
RN70_RS08145	COG0552	protein localization to endoplasmic reticulum
RN70_RS08150	COG1196	nuclear chromosome segregation
RN70_RS08160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RN70_RS08175	COG0416	fatty acid biosynthetic process
RN70_RS08180	COG1349	DNA-binding transcription factor activity
RN70_RS08190	COG1760	l-serine dehydratase
RN70_RS08195	COG1760	l-serine dehydratase
RN70_RS08200	COG1461	Dihydroxyacetone kinase
RN70_RS08205	COG1302	Protein conserved in bacteria
RN70_RS08210	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RN70_RS08220	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RN70_RS08225	COG1162	GTPase activity
RN70_RS08240	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RN70_RS08245	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RN70_RS08245	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RN70_RS08250	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RN70_RS08265	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RN70_RS08270	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RN70_RS08275	COG1758	RNA polymerase activity
RN70_RS08305	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RN70_RS08310	COG0284	orotidine-5'-phosphate decarboxylase activity
RN70_RS08315	COG0167	dihydroorotate dehydrogenase activity
RN70_RS08325	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RN70_RS08330	COG0505	Belongs to the CarA family
RN70_RS08350	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
RN70_RS08355	COG0564	pseudouridine synthase activity
RN70_RS08365	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RN70_RS08370	COG3599	regulation of cell shape
RN70_RS08380	COG0673	inositol 2-dehydrogenase activity
RN70_RS08390	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RN70_RS08395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RN70_RS08400	COG1737	Transcriptional regulator
RN70_RS08405	COG0762	integral membrane protein
RN70_RS08410	COG1799	cell septum assembly
RN70_RS08415	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RN70_RS08420	COG1496	oxidoreductase activity
RN70_RS08425	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RN70_RS08430	COG0849	cell division
RN70_RS08440	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RN70_RS08445	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RN70_RS08450	COG0768	penicillin binding
RN70_RS08455	COG4839	cell division protein FtsL
RN70_RS08460	COG0275	rRNA processing
RN70_RS08465	COG2001	Belongs to the MraZ family
RN70_RS08470	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
RN70_RS08475	COG0454	-acetyltransferase
RN70_RS08480	COG1011	Hydrolase
RN70_RS08505	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RN70_RS08510	COG1053	succinate dehydrogenase
RN70_RS08515	COG2009	succinate dehydrogenase
RN70_RS08520	COG0322	excinuclease ABC activity
RN70_RS08525	COG3118	belongs to the thioredoxin family
RN70_RS08530	COG1193	negative regulation of DNA recombination
RN70_RS08535	COG1796	DNA polymerase
RN70_RS08535	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
RN70_RS08545	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
RN70_RS08550	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RN70_RS08560	COG0072	phenylalanine-tRNA ligase activity
RN70_RS08560	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RN70_RS08565	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RN70_RS08570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RN70_RS08575	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RN70_RS08590	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RN70_RS08595	COG0742	ribosomal rna small subunit methyltransferase
RN70_RS08610	COG0584	glycerophosphoryl diester phosphodiesterase
RN70_RS08615	COG3679	Belongs to the UPF0342 family
RN70_RS08630	COG0109	protoheme IX farnesyltransferase activity
RN70_RS08635	COG1612	heme a metabolic process
RN70_RS08645	COG0772	Belongs to the SEDS family
RN70_RS08650	COG4838	Belongs to the UPF0358 family
RN70_RS08655	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RN70_RS08660	COG4896	Protein conserved in bacteria
RN70_RS08665	COG1902	pentaerythritol trinitrate reductase activity
RN70_RS08670	COG1217	gtp-binding protein TYPA
RN70_RS08680	COG0483	inositol monophosphate 1-phosphatase activity
RN70_RS08700	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RN70_RS08705	COG1177	transmembrane transport
RN70_RS08715	COG3842	ATPase activity
RN70_RS08725	COG4476	Belongs to the UPF0223 family
RN70_RS08755	COG0242	peptide deformylase activity
RN70_RS08765	COG5503	Protein of unknown function (DUF1447)
RN70_RS08770	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
RN70_RS08775	COG0569	domain protein
RN70_RS08780	COG1294	oxidase, subunit
RN70_RS08785	COG1271	oxidase subunit
RN70_RS08795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RN70_RS08800	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RN70_RS08810	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
RN70_RS08825	COG1122	ATPase activity
RN70_RS08835	COG0151	Belongs to the GarS family
RN70_RS08840	COG0138	bifunctional purine biosynthesis protein purh
RN70_RS08850	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RN70_RS08855	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
RN70_RS08860	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RN70_RS08865	COG0047	phosphoribosylformylglycinamidine synthase activity
RN70_RS08870	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RN70_RS08875	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RN70_RS08880	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RN70_RS08885	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RN70_RS08890	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RN70_RS08905	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RN70_RS08915	COG1845	cytochrome c oxidase, subunit III
RN70_RS08920	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
RN70_RS08930	COG3212	peptidase
RN70_RS08940	COG1134	teichoic acid transport
RN70_RS08960	COG0438	transferase activity, transferring glycosyl groups
RN70_RS08965	COG1215	transferase activity, transferring glycosyl groups
RN70_RS08980	COG1682	transport, permease protein
RN70_RS08985	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
RN70_RS08990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RN70_RS08995	COG1316	TRANSCRIPTIONal
RN70_RS09020	COG3594	Acyltransferase
RN70_RS09025	COG0436	Aminotransferase
RN70_RS09030	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
RN70_RS09035	COG2267	carboxylic ester hydrolase activity
RN70_RS09040	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
RN70_RS09045	COG1169	isochorismate synthase
RN70_RS09050	COG1575	Belongs to the MenA family. Type 1 subfamily
RN70_RS09055	COG0390	transport system, permease component
RN70_RS09060	COG4619	ABC transporter
RN70_RS09110	COG4903	ComK protein
RN70_RS09125	COG4873	Protein conserved in bacteria
RN70_RS09140	COG0737	Belongs to the 5'-nucleotidase family
RN70_RS09150	COG1696	Membrane protein involved in D-alanine export
RN70_RS09160	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
RN70_RS09165	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RN70_RS09170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RN70_RS09175	COG0861	Integral membrane protein TerC family
RN70_RS09190	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RN70_RS09195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RN70_RS09200	COG2814	Major facilitator Superfamily
RN70_RS09205	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
RN70_RS09210	COG2382	esterase
RN70_RS09215	COG1115	amino acid carrier protein
RN70_RS09220	COG0628	permease
RN70_RS09235	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RN70_RS09250	COG0569	domain protein
RN70_RS09250	COG0475	glutathione-regulated potassium exporter activity
RN70_RS09255	COG2239	Acts as a magnesium transporter
RN70_RS09260	COG0564	pseudouridine synthase activity
RN70_RS09265	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RN70_RS09270	COG2357	RelA SpoT domain protein
RN70_RS09280	COG4116	CYTH
RN70_RS09285	COG2346	COG2346, Truncated hemoglobins
RN70_RS09295	COG1164	Oligoendopeptidase f
RN70_RS09300	COG4469	Competence protein
RN70_RS09305	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RN70_RS09320	COG1393	Belongs to the ArsC family
RN70_RS09325	COG0180	Tryptophanyl-tRNA synthetase
RN70_RS09330	COG4166	transmembrane transport
RN70_RS09335	COG4608	Belongs to the ABC transporter superfamily
RN70_RS09340	COG0444	Belongs to the ABC transporter superfamily
RN70_RS09345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RN70_RS09350	COG0601	transmembrane transport
RN70_RS09380	COG0542	response to heat
RN70_RS09395	COG0561	phosphatase activity
RN70_RS09400	COG0446	pyridine nucleotide-disulphide oxidoreductase
RN70_RS09410	COG0179	Fumarylacetoacetate (FAA) hydrolase
RN70_RS09415	COG1074	ATP-dependent DNA helicase activity
RN70_RS09420	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
RN70_RS09440	COG0137	argininosuccinate synthase activity
RN70_RS09450	COG0584	glycerophosphoryl diester phosphodiesterase
RN70_RS09465	COG1012	belongs to the aldehyde dehydrogenase family
RN70_RS09470	COG1098	S1 RNA binding domain
RN70_RS09475	COG1278	Cold shock
RN70_RS09495	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RN70_RS09505	COG2111	Na H antiporter
RN70_RS09505	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RN70_RS09510	COG2111	Na H antiporter
RN70_RS09515	COG1006	Multisubunit Na H antiporter MnhC subunit
RN70_RS09520	COG0651	ATP synthesis coupled electron transport
RN70_RS09525	COG1863	multisubunit Na H antiporter MnhE subunit
RN70_RS09530	COG2212	antiporter activity
RN70_RS09535	COG1320	monovalent cation:proton antiporter activity
RN70_RS09545	COG2056	Na+-H+ antiporter family
RN70_RS09550	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RN70_RS09555	COG1252	NADH dehydrogenase
RN70_RS09565	COG0316	Belongs to the HesB IscA family
RN70_RS09570	COG4844	belongs to the
RN70_RS09575	COG1252	NADH dehydrogenase
RN70_RS09580	COG4837	Protein of unknown function (DUF1462)
RN70_RS09585	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
RN70_RS09590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RN70_RS09595	COG0647	UMP catabolic process
RN70_RS09600	COG2445	Protein of unknown function DUF86
RN70_RS09610	COG4470	Protein conserved in bacteria
RN70_RS09615	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
RN70_RS09620	COG0737	Belongs to the 5'-nucleotidase family
RN70_RS09625	COG0730	response to heat
RN70_RS09630	COG1801	Protein of unknown function DUF72
RN70_RS09640	COG2070	2-Nitropropane dioxygenase
RN70_RS09645	COG4536	flavin adenine dinucleotide binding
RN70_RS09670	COG5632	N-Acetylmuramoyl-L-alanine amidase
RN70_RS09670	COG1388	LysM domain
RN70_RS09765	COG0052	Belongs to the universal ribosomal protein uS2 family
RN70_RS09790	COG1783	phage Terminase large subunit
RN70_RS09880	COG0305	Participates in initiation and elongation during chromosome replication
RN70_RS09965	COG0719	Fe-S assembly protein
RN70_RS09970	COG0822	iron-sulfur transferase activity
RN70_RS09980	COG0719	Fe-S assembly protein
RN70_RS09985	COG0396	ATPase activity
RN70_RS09995	COG1464	Belongs to the NlpA lipoprotein family
RN70_RS10000	COG1464	Belongs to the NlpA lipoprotein family
RN70_RS10005	COG2011	ABC-type metal ion transport system permease component
RN70_RS10010	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RN70_RS10020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RN70_RS10025	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
RN70_RS10030	COG0509	glycine decarboxylation via glycine cleavage system
RN70_RS10035	COG1393	Belongs to the ArsC family
RN70_RS10040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RN70_RS10050	COG0710	3-dehydroquinate dehydratase activity
RN70_RS10060	COG1764	response to oxidative stress
RN70_RS10070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
RN70_RS10080	COG2814	Major facilitator Superfamily
RN70_RS10100	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RN70_RS10105	COG0557	exoribonuclease II activity
RN70_RS10110	COG1647	Serine aminopeptidase, S33
RN70_RS10115	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RN70_RS10130	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
RN70_RS10135	COG0149	triose-phosphate isomerase activity
RN70_RS10140	COG0126	phosphoglycerate kinase activity
RN70_RS10145	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RN70_RS10165	COG1090	epimerase
RN70_RS10175	COG0740	serine-type endopeptidase activity
RN70_RS10185	COG1481	regulation of sporulation
RN70_RS10190	COG0391	Required for morphogenesis under gluconeogenic growth conditions
RN70_RS10195	COG1660	Displays ATPase and GTPase activities
RN70_RS10200	COG0492	ferredoxin-NADP+ reductase activity
RN70_RS10210	COG0110	maltose O-acetyltransferase activity
RN70_RS10220	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
RN70_RS10250	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RN70_RS10255	COG0653	protein targeting
RN70_RS10270	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
RN70_RS10280	COG1739	Uncharacterized protein family UPF0029
RN70_RS10285	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RN70_RS10305	COG2195	Cleaves the N-terminal amino acid of tripeptides
RN70_RS10310	COG1929	Belongs to the glycerate kinase type-1 family
RN70_RS10330	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RN70_RS10340	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RN70_RS10345	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RN70_RS10360	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RN70_RS10365	COG3104	oligopeptide transport
RN70_RS10370	COG3104	oligopeptide transport
RN70_RS10385	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RN70_RS10390	COG1174	glycine betaine transport
RN70_RS10395	COG1125	glycine betaine transport
RN70_RS10395	COG0517	IMP dehydrogenase activity
RN70_RS10400	COG0514	ATP-dependent DNA helicase (RecQ)
RN70_RS10405	COG0488	(ABC) transporter
RN70_RS10415	COG1368	sulfuric ester hydrolase activity
RN70_RS10425	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RN70_RS10445	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RN70_RS10445	COG0512	Glutamine amidotransferase of anthranilate synthase
RN70_RS10455	COG0720	synthase
RN70_RS10470	COG2261	transglycosylase associated protein
RN70_RS10480	COG0463	Glycosyl transferase, family 2
RN70_RS10485	COG1253	flavin adenine dinucleotide binding
RN70_RS10490	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RN70_RS10490	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RN70_RS10490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RN70_RS10495	COG1105	Belongs to the carbohydrate kinase PfkB family
RN70_RS10500	COG1349	DNA-binding transcription factor activity
RN70_RS10505	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RN70_RS10510	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
RN70_RS10535	COG0039	L-malate dehydrogenase activity
RN70_RS10545	COG4989	oxidoreductase activity
RN70_RS10560	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
RN70_RS10565	COG4988	ABC transporter
RN70_RS10570	COG1968	undecaprenyl-diphosphatase activity
RN70_RS10580	COG1671	Belongs to the UPF0178 family
RN70_RS10585	COG1611	Belongs to the LOG family
RN70_RS10615	COG2814	Major facilitator Superfamily
RN70_RS10620	COG0583	DNA-binding transcription factor activity
RN70_RS10635	COG0217	transcriptional regulatory protein
RN70_RS10645	COG2022	thiamine diphosphate biosynthetic process
RN70_RS10655	COG0352	thiamine-phosphate diphosphorylase activity
RN70_RS10670	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
RN70_RS10680	COG2205	protein histidine kinase activity
RN70_RS10685	COG0745	RESPONSE REGULATOR receiver
RN70_RS10695	COG2130	NADP-dependent
RN70_RS10700	COG0702	epimerase
RN70_RS10720	COG1388	LysM domain
RN70_RS10720	COG3942	CHAP domain
RN70_RS10725	COG0306	phosphate transporter
RN70_RS10730	COG1392	Phosphate transport regulator
RN70_RS10735	COG0577	efflux transmembrane transporter activity
RN70_RS10740	COG1136	(ABC) transporter
RN70_RS10750	COG0745	RESPONSE REGULATOR receiver
RN70_RS10755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RN70_RS10765	COG0657	acetylesterase activity
RN70_RS10770	COG3949	Membrane
RN70_RS10780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RN70_RS10785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RN70_RS10790	COG1120	ATPase activity
RN70_RS10795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
RN70_RS10800	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RN70_RS10820	COG1132	(ABC) transporter
RN70_RS10825	COG1686	Belongs to the peptidase S11 family
RN70_RS10830	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RN70_RS10835	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
RN70_RS10840	COG1682	transport, permease protein
RN70_RS10845	COG1134	teichoic acid transport
RN70_RS10850	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
RN70_RS10865	COG1121	(ABC) transporter
RN70_RS10870	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RN70_RS10875	COG0803	Belongs to the bacterial solute-binding protein 9 family
RN70_RS10880	COG1320	monovalent cation:proton antiporter activity
RN70_RS10885	COG2212	antiporter activity
RN70_RS10890	COG1863	multisubunit Na H antiporter MnhE subunit
RN70_RS10900	COG1006	Multisubunit Na H antiporter MnhC subunit
RN70_RS10905	COG2111	Na H antiporter
RN70_RS10910	COG2111	Na H antiporter
RN70_RS10910	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RN70_RS10915	COG0582	viral genome integration into host DNA
RN70_RS10960	COG0596	Alpha beta hydrolase
RN70_RS10970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RN70_RS10975	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RN70_RS10980	COG0018	arginyl-trna synthetase
RN70_RS10995	COG1078	dGTPase activity
RN70_RS11005	COG0655	NAD(P)H dehydrogenase (quinone) activity
RN70_RS11010	COG4844	belongs to the
RN70_RS11015	COG0095	Lipoate-protein ligase
RN70_RS11045	COG0471	metal ion transport
RN70_RS11050	COG2814	Major facilitator Superfamily
RN70_RS11055	COG1566	PFAM secretion protein HlyD family protein
RN70_RS11065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RN70_RS11075	COG2363	Small membrane protein
RN70_RS11105	COG0183	Belongs to the thiolase family
RN70_RS11110	COG0318	PFAM AMP-dependent synthetase and ligase
RN70_RS11115	COG0588	phosphoglycerate mutase activity
RN70_RS11120	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RN70_RS11130	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
RN70_RS11135	COG0363	glucosamine-6-phosphate deaminase activity
RN70_RS11165	COG0561	phosphatase activity
RN70_RS11175	COG1428	Deoxynucleoside kinase
RN70_RS11180	COG1428	Deoxynucleoside kinase
RN70_RS11195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RN70_RS11205	COG1473	amidohydrolase
RN70_RS11210	COG0028	Belongs to the TPP enzyme family
RN70_RS11215	COG3527	Alpha-acetolactate decarboxylase
RN70_RS11225	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RN70_RS11230	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RN70_RS11235	COG0049	tRNA binding
RN70_RS11240	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RN70_RS11250	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RN70_RS11255	COG0085	RNA polymerase activity
RN70_RS11260	COG2813	Specifically methylates the guanine in position
RN70_RS11270	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RN70_RS11275	COG0081	regulation of translation
RN70_RS11280	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RN70_RS11285	COG0250	Participates in transcription elongation, termination and antitermination
RN70_RS11290	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RN70_RS11310	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
RN70_RS11315	COG0215	cysteine-tRNA ligase activity
RN70_RS11325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RN70_RS11330	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RN70_RS11340	COG4956	integral membrane protein (PIN domain superfamily)
RN70_RS11345	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
RN70_RS11355	COG3869	Catalyzes the specific phosphorylation of arginine residues in
RN70_RS11360	COG3880	PFAM UvrB UvrC protein
RN70_RS11365	COG4463	regulation of RNA biosynthetic process
RN70_RS11370	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RN70_RS11375	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
RN70_RS11380	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
RN70_RS11385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RN70_RS11390	COG1289	transmembrane transporter activity
RN70_RS11480	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
RN70_RS11490	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RN70_RS11500	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
RN70_RS11505	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RN70_RS11520	COG1098	S1 RNA binding domain
RN70_RS11530	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
RN70_RS11535	COG3956	TIGRFAM MazG family protein
RN70_RS11540	COG2244	polysaccharide biosynthetic process
RN70_RS11545	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RN70_RS11550	COG0193	aminoacyl-tRNA hydrolase activity
RN70_RS11580	COG1073	alpha beta
RN70_RS11590	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RN70_RS11595	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RN70_RS11600	COG2088	sporulation resulting in formation of a cellular spore
RN70_RS11605	COG0251	oxidation-reduction process
RN70_RS11610	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RN70_RS11615	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
RN70_RS11620	COG4466	Protein conserved in bacteria
RN70_RS11630	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
RN70_RS11635	COG0084	hydrolase, TatD family'
RN70_RS11645	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RN70_RS11650	COG2827	Endonuclease containing a URI domain
RN70_RS11655	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
RN70_RS11665	COG1774	PSP1 C-terminal conserved region
RN70_RS11675	COG3870	Protein conserved in bacteria
RN70_RS11680	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RN70_RS11685	COG1982	Orn Lys Arg decarboxylase major
RN70_RS11715	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RN70_RS11720	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RN70_RS11725	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RN70_RS11740	COG0493	'glutamate synthase
RN70_RS11745	COG0069	glutamate synthase activity
RN70_RS11745	COG0067	glutamate synthase
RN70_RS11745	COG0070	glutamate synthase
RN70_RS11750	COG0583	DNA-binding transcription factor activity
RN70_RS11765	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RN70_RS11780	COG1309	transcriptional regulator
RN70_RS11795	COG0626	cystathionine gamma-synthase activity
RN70_RS11800	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RN70_RS11810	COG2272	Belongs to the type-B carboxylesterase lipase family
RN70_RS11815	COG0733	neurotransmitter:sodium symporter activity
RN70_RS11825	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
RN70_RS11830	COG0574	Belongs to the PEP-utilizing enzyme family
RN70_RS11830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RN70_RS11840	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
RN70_RS11855	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RN70_RS11875	COG1124	(ABC) transporter
RN70_RS11880	COG0444	Belongs to the ABC transporter superfamily
RN70_RS11885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RN70_RS11890	COG0601	transmembrane transport
RN70_RS11925	COG2314	TM2 domain
RN70_RS11930	COG3189	MarR family transcriptional regulator
RN70_RS11935	COG2814	Major facilitator Superfamily
RN70_RS11960	COG1683	Conserved Protein
RN70_RS11965	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
RN70_RS11975	COG1136	(ABC) transporter
RN70_RS11975	COG0577	efflux transmembrane transporter activity
RN70_RS12025	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RN70_RS12025	COG0519	Catalyzes the synthesis of GMP from XMP
RN70_RS12030	COG0516	GMP reductase activity
RN70_RS12030	COG0517	IMP dehydrogenase activity
RN70_RS12035	COG2233	PERMEase
RN70_RS12040	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RN70_RS12055	COG5183	chlorophyll binding
RN70_RS12065	COG1823	symporter activity
RN70_RS12070	COG0778	Nitroreductase
RN70_RS12075	COG0450	alkyl hydroperoxide reductase
RN70_RS12085	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RN70_RS12090	COG5646	InterPro IPR014922
RN70_RS12095	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RN70_RS12100	COG2011	ABC-type metal ion transport system permease component
RN70_RS12105	COG1464	Belongs to the NlpA lipoprotein family
RN70_RS12110	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
RN70_RS12115	COG2814	Major facilitator Superfamily
RN70_RS12125	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RN70_RS12135	COG0360	Binds together with S18 to 16S ribosomal RNA
RN70_RS12155	COG0012	GTP binding
RN70_RS12160	COG4481	Protein conserved in bacteria
RN70_RS12165	COG0668	transmembrane transport
RN70_RS12170	COG1475	DNA binding
RN70_RS12175	COG0626	cystathionine gamma-synthase activity
RN70_RS12180	COG0626	cystathionine gamma-synthase activity
RN70_RS12185	COG0646	methionine synthase
RN70_RS12185	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RN70_RS12200	COG0829	nickel cation binding
RN70_RS12210	COG0830	nickel cation binding
RN70_RS12215	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
RN70_RS12220	COG2353	YceI-like domain
RN70_RS12225	COG1846	Transcriptional regulator
RN70_RS12230	COG0346	lactoylglutathione lyase activity
RN70_RS12235	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RN70_RS12240	COG0400	carboxylic ester hydrolase activity
RN70_RS12270	COG1475	DNA binding
RN70_RS12275	COG0357	Ribosomal RNA small subunit methyltransferase G
RN70_RS12280	COG0445	tRNA wobble uridine modification
RN70_RS12285	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RN70_RS12290	COG0594	ribonuclease P activity