locus-tag	class	description
I7827_RS00050	COG4607	ABC-type enterochelin transport system periplasmic component
I7827_RS00055	COG4604	ABC transporter, ATP-binding protein
I7827_RS00060	COG4605	iron ion homeostasis
I7827_RS00065	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I7827_RS00075	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I7827_RS00080	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I7827_RS00085	COG1780	Probably involved in ribonucleotide reductase function
I7827_RS00095	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I7827_RS00100	COG3104	oligopeptide transport
I7827_RS00105	COG3104	oligopeptide transport
I7827_RS00110	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
I7827_RS00120	COG1174	glycine betaine transport
I7827_RS00125	COG1125	glycine betaine transport
I7827_RS00125	COG0517	IMP dehydrogenase activity
I7827_RS00130	COG0514	ATP-dependent DNA helicase (RecQ)
I7827_RS00135	COG0488	(ABC) transporter
I7827_RS00145	COG1368	sulfuric ester hydrolase activity
I7827_RS00150	COG1984	allophanate hydrolase subunit 2
I7827_RS00170	COG0512	Glutamine amidotransferase of anthranilate synthase
I7827_RS00180	COG0720	synthase
I7827_RS00185	COG0602	queuosine metabolic process
I7827_RS00195	COG1695	Transcriptional regulator
I7827_RS00215	COG0656	L-ascorbic acid biosynthetic process
I7827_RS00220	COG1187	pseudouridine synthase activity
I7827_RS00225	COG2814	Major facilitator Superfamily
I7827_RS00230	COG1253	flavin adenine dinucleotide binding
I7827_RS00235	COG2267	carboxylic ester hydrolase activity
I7827_RS00240	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I7827_RS00240	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I7827_RS00240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I7827_RS00245	COG1105	Belongs to the carbohydrate kinase PfkB family
I7827_RS00250	COG1349	DNA-binding transcription factor activity
I7827_RS00255	COG1473	amidohydrolase
I7827_RS00260	COG4989	oxidoreductase activity
I7827_RS00265	COG0523	cobalamin synthesis protein
I7827_RS00275	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I7827_RS00280	COG4988	ABC transporter
I7827_RS00285	COG1968	undecaprenyl-diphosphatase activity
I7827_RS00295	COG1671	Belongs to the UPF0178 family
I7827_RS00310	COG1683	Conserved Protein
I7827_RS00325	COG1012	belongs to the aldehyde dehydrogenase family
I7827_RS00345	COG0025	NhaP-type Na H and K H
I7827_RS00370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I7827_RS00375	COG0765	amino acid transport
I7827_RS00380	COG0765	amino acid transport
I7827_RS00385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I7827_RS00390	COG1126	abc transporter atp-binding protein
I7827_RS00400	COG0778	Nitroreductase
I7827_RS00405	COG1136	(ABC) transporter
I7827_RS00410	COG0577	efflux transmembrane transporter activity
I7827_RS00420	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I7827_RS00425	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I7827_RS00440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7827_RS00440	COG1263	PTS System
I7827_RS00445	COG0010	Belongs to the arginase family
I7827_RS00450	COG1914	H( )-stimulated, divalent metal cation uptake system
I7827_RS00455	COG1660	Displays ATPase and GTPase activities
I7827_RS00485	COG1846	Transcriptional regulator
I7827_RS00490	COG2818	Glycosylase
I7827_RS00500	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I7827_RS00515	COG0667	Aldo Keto reductase
I7827_RS00520	COG0492	ferredoxin-NADP+ reductase activity
I7827_RS00525	COG2207	Transcriptional regulator
I7827_RS00530	COG2271	Major facilitator Superfamily
I7827_RS00535	COG3226	Transcriptional regulator
I7827_RS00545	COG1253	flavin adenine dinucleotide binding
I7827_RS00555	COG2197	response regulator
I7827_RS00560	COG4585	Histidine kinase
I7827_RS00565	COG0842	Transport permease protein
I7827_RS00570	COG1131	(ABC) transporter
I7827_RS00580	COG0672	)-iron permease
I7827_RS00585	COG2837	iron assimilation
I7827_RS00590	COG2822	iron ion transport
I7827_RS00605	COG0492	ferredoxin-NADP+ reductase activity
I7827_RS00615	COG1132	(ABC) transporter
I7827_RS00620	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I7827_RS00620	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I7827_RS00630	COG1447	Phosphotransferase system cellobiose-specific component IIA
I7827_RS00635	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I7827_RS00635	COG3711	transcriptional antiterminator
I7827_RS00640	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I7827_RS00645	COG2723	6-phospho-beta-galactosidase activity
I7827_RS00655	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I7827_RS00660	COG2264	protein methyltransferase activity
I7827_RS00665	COG0803	Belongs to the bacterial solute-binding protein 9 family
I7827_RS00665	COG3443	Belongs to the bacterial solute-binding protein 9 family
I7827_RS00675	COG1136	(ABC) transporter
I7827_RS00690	COG4607	ABC-type enterochelin transport system periplasmic component
I7827_RS00700	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I7827_RS00705	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I7827_RS00715	COG0477	Major facilitator Superfamily
I7827_RS00720	COG0477	Major facilitator Superfamily
I7827_RS00730	COG3732	PTS system glucitol sorbitol-specific
I7827_RS00735	COG3730	PTS system glucitol sorbitol-specific
I7827_RS00745	COG3711	transcriptional antiterminator
I7827_RS00745	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I7827_RS00755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I7827_RS00760	COG0740	serine-type endopeptidase activity
I7827_RS00765	COG1309	transcriptional regulator
I7827_RS00775	COG0400	carboxylic ester hydrolase activity
I7827_RS00780	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I7827_RS00785	COG0346	lactoylglutathione lyase activity
I7827_RS00790	COG1846	Transcriptional regulator
I7827_RS00795	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I7827_RS00800	COG0626	cystathionine gamma-synthase activity
I7827_RS00810	COG4978	Transcriptional regulator
I7827_RS00810	COG0789	Transcriptional regulator
I7827_RS00830	COG1131	(ABC) transporter
I7827_RS00835	COG2188	Transcriptional regulator
I7827_RS00840	COG2819	hydrolase of the alpha beta superfamily
I7827_RS00845	COG0693	protein deglycase activity
I7827_RS00850	COG3173	Aminoglycoside phosphotransferase
I7827_RS00860	COG0584	glycerophosphoryl diester phosphodiesterase
I7827_RS00880	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I7827_RS00885	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I7827_RS00900	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
I7827_RS00905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I7827_RS00910	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I7827_RS00920	COG1486	melibiose metabolic process
I7827_RS00925	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I7827_RS00945	COG1388	LysM domain
I7827_RS00950	COG2910	NAD(P)H-binding
I7827_RS00955	COG1959	2 iron, 2 sulfur cluster binding
I7827_RS00965	COG0438	transferase activity, transferring glycosyl groups
I7827_RS00975	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I7827_RS00980	COG1902	pentaerythritol trinitrate reductase activity
I7827_RS00985	COG3037	sugar-specific permease SgaT UlaA
I7827_RS00995	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I7827_RS01005	COG2723	6-phospho-beta-galactosidase activity
I7827_RS01010	COG2723	6-phospho-beta-galactosidase activity
I7827_RS01015	COG1263	PTS System
I7827_RS01015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7827_RS01015	COG2190	(PTS) system
I7827_RS01020	COG3711	transcriptional antiterminator
I7827_RS01025	COG3239	Fatty acid desaturase
I7827_RS01035	COG1363	Peptidase, m42
I7827_RS01045	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
I7827_RS01050	COG2357	RelA SpoT domain protein
I7827_RS01055	COG1486	melibiose metabolic process
I7827_RS01060	COG1263	PTS System
I7827_RS01060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7827_RS01065	COG1737	Transcriptional regulator
I7827_RS01070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I7827_RS01075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I7827_RS01080	COG1279	arginine transmembrane transporter activity
I7827_RS01090	COG1263	PTS System
I7827_RS01090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7827_RS01095	COG2824	Alkylphosphonate utilization operon protein PhnA
I7827_RS01105	COG3559	Exporter of polyketide antibiotics
I7827_RS01110	COG1131	(ABC) transporter
I7827_RS01125	COG2723	6-phospho-beta-galactosidase activity
I7827_RS01130	COG1447	Phosphotransferase system cellobiose-specific component IIA
I7827_RS01135	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I7827_RS01145	COG1113	amino acid transport
I7827_RS01155	COG0402	S-adenosylhomocysteine deaminase activity
I7827_RS01160	COG1012	belongs to the aldehyde dehydrogenase family
I7827_RS01165	COG0531	amino acid
I7827_RS01170	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I7827_RS01175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I7827_RS01215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I7827_RS01220	COG1136	(ABC) transporter
I7827_RS01225	COG0577	efflux transmembrane transporter activity
I7827_RS01230	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I7827_RS01235	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I7827_RS01235	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I7827_RS01240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I7827_RS01245	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I7827_RS01255	COG3711	transcriptional antiterminator
I7827_RS01270	COG1028	Short-chain dehydrogenase reductase Sdr
I7827_RS01275	COG1312	Catalyzes the dehydration of D-mannonate
I7827_RS01280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I7827_RS01285	COG0800	Aldolase
I7827_RS01290	COG1414	Transcriptional regulator
I7827_RS01295	COG2808	Putative FMN-binding domain
I7827_RS01300	COG0583	DNA-binding transcription factor activity
I7827_RS01355	COG4607	ABC-type enterochelin transport system periplasmic component
I7827_RS01360	COG3708	Transcriptional regulator
I7827_RS01360	COG2207	Transcriptional regulator
I7827_RS01375	COG2213	PTS system mannitol-specific
I7827_RS01380	COG3711	transcriptional antiterminator
I7827_RS01390	COG0246	Mannitol dehydrogenase
I7827_RS01400	COG0596	Alpha beta hydrolase
I7827_RS01415	COG0596	Alpha beta hydrolase
I7827_RS01425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I7827_RS01430	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I7827_RS01435	COG0018	arginyl-trna synthetase
I7827_RS01450	COG1078	dGTPase activity
I7827_RS01470	COG1082	Xylose isomerase domain protein TIM barrel
I7827_RS01475	COG2814	Major facilitator Superfamily
I7827_RS01480	COG4844	belongs to the
I7827_RS01485	COG0095	Lipoate-protein ligase
I7827_RS01505	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I7827_RS01515	COG2011	ABC-type metal ion transport system permease component
I7827_RS01530	COG0786	glutamate:sodium symporter activity
I7827_RS01535	COG0531	amino acid
I7827_RS01540	COG2363	Small membrane protein
I7827_RS01550	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I7827_RS01575	COG1131	(ABC) transporter
I7827_RS01585	COG0363	glucosamine-6-phosphate deaminase activity
I7827_RS01590	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I7827_RS01595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7827_RS01595	COG1263	PTS System
I7827_RS01595	COG2190	(PTS) system
I7827_RS01600	COG1737	Transcriptional regulator
I7827_RS01610	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I7827_RS01615	COG1469	GTP cyclohydrolase I activity
I7827_RS01625	COG0431	NADPH-dependent FMN reductase
I7827_RS01630	COG0561	phosphatase activity
I7827_RS01640	COG1428	Deoxynucleoside kinase
I7827_RS01645	COG1428	Deoxynucleoside kinase
I7827_RS01655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I7827_RS01660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I7827_RS01670	COG1473	amidohydrolase
I7827_RS01675	COG1473	amidohydrolase
I7827_RS01680	COG1473	amidohydrolase
I7827_RS01685	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I7827_RS01690	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I7827_RS01695	COG0049	tRNA binding
I7827_RS01700	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I7827_RS01710	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I7827_RS01715	COG0085	RNA polymerase activity
I7827_RS01720	COG2813	Specifically methylates the guanine in position
I7827_RS01725	COG0222	ribosome binding
I7827_RS01730	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I7827_RS01735	COG0081	regulation of translation
I7827_RS01740	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I7827_RS01755	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I7827_RS01770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I7827_RS01775	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I7827_RS01780	COG0215	cysteine-tRNA ligase activity
I7827_RS01805	COG4956	integral membrane protein (PIN domain superfamily)
I7827_RS01810	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I7827_RS01815	COG0542	response to heat
I7827_RS01820	COG3869	Catalyzes the specific phosphorylation of arginine residues in
I7827_RS01825	COG3880	PFAM UvrB UvrC protein
I7827_RS01830	COG4463	regulation of RNA biosynthetic process
I7827_RS01835	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I7827_RS01840	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I7827_RS01845	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I7827_RS01850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I7827_RS01945	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I7827_RS01965	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I7827_RS01970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I7827_RS01985	COG1098	S1 RNA binding domain
I7827_RS01995	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I7827_RS02000	COG3956	TIGRFAM MazG family protein
I7827_RS02005	COG2244	polysaccharide biosynthetic process
I7827_RS02010	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I7827_RS02015	COG0193	aminoacyl-tRNA hydrolase activity
I7827_RS02025	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I7827_RS02030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I7827_RS02035	COG2088	sporulation resulting in formation of a cellular spore
I7827_RS02040	COG0251	oxidation-reduction process
I7827_RS02045	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I7827_RS02050	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I7827_RS02055	COG4466	Protein conserved in bacteria
I7827_RS02065	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I7827_RS02070	COG0084	hydrolase, TatD family'
I7827_RS02075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I7827_RS02075	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I7827_RS02080	COG2002	toxin-antitoxin pair type II binding
I7827_RS02085	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I7827_RS02090	COG2827	Endonuclease containing a URI domain
I7827_RS02095	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I7827_RS02105	COG1774	PSP1 C-terminal conserved region
I7827_RS02110	COG0470	DNA polymerase III
I7827_RS02115	COG3870	Protein conserved in bacteria
I7827_RS02125	COG1982	Orn Lys Arg decarboxylase major
I7827_RS02150	COG4667	esterase of the alpha-beta hydrolase superfamily
I7827_RS02160	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I7827_RS02165	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I7827_RS02180	COG2188	Transcriptional regulator
I7827_RS02185	COG0366	Alpha amylase catalytic
I7827_RS02190	COG1263	PTS System
I7827_RS02190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7827_RS02200	COG0791	NLP P60 protein
I7827_RS02205	COG4948	Mandelate Racemase Muconate Lactonizing
I7827_RS02210	COG1619	proteins homologs of microcin C7 resistance protein MccF
I7827_RS02220	COG0493	'glutamate synthase
I7827_RS02225	COG0070	glutamate synthase
I7827_RS02225	COG0069	glutamate synthase activity
I7827_RS02225	COG0067	glutamate synthase
I7827_RS02230	COG0583	DNA-binding transcription factor activity
I7827_RS02235	COG2094	Belongs to the DNA glycosylase MPG family
I7827_RS02250	COG0346	lactoylglutathione lyase activity
I7827_RS02275	COG2814	Major facilitator Superfamily
I7827_RS02285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I7827_RS02300	COG2076	Multidrug Resistance protein
I7827_RS02305	COG2076	Multidrug Resistance protein
I7827_RS02325	COG1695	Transcriptional regulator
I7827_RS02350	COG0346	lactoylglutathione lyase activity
I7827_RS02355	COG0400	carboxylic ester hydrolase activity
I7827_RS02385	COG0519	Catalyzes the synthesis of GMP from XMP
I7827_RS02385	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I7827_RS02390	COG0516	GMP reductase activity
I7827_RS02390	COG0517	IMP dehydrogenase activity
I7827_RS02395	COG2233	PERMEase
I7827_RS02400	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I7827_RS02415	COG2070	2-Nitropropane dioxygenase
I7827_RS02420	COG0778	Nitroreductase
I7827_RS02425	COG0733	neurotransmitter:sodium symporter activity
I7827_RS02435	COG0471	metal ion transport
I7827_RS02450	COG1072	(Pantothenic acid kinase))
I7827_RS02455	COG0384	phenazine biosynthesis protein PhzF
I7827_RS02505	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I7827_RS02515	COG5484	DNA packaging
I7827_RS02515	COG3728	DNA packaging
I7827_RS02570	COG4974	Belongs to the 'phage' integrase family
I7827_RS02580	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I7827_RS02590	COG0360	Binds together with S18 to 16S ribosomal RNA
I7827_RS02595	COG0012	GTP binding
I7827_RS02600	COG4481	Protein conserved in bacteria
I7827_RS02605	COG0668	transmembrane transport
I7827_RS02610	COG1475	DNA binding
I7827_RS02615	COG0626	cystathionine gamma-synthase activity
I7827_RS02620	COG0626	cystathionine gamma-synthase activity
I7827_RS02625	COG0646	methionine synthase
I7827_RS02625	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I7827_RS02630	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I7827_RS02640	COG1966	Carbon starvation protein
I7827_RS02645	COG1475	DNA binding
I7827_RS02650	COG0357	Ribosomal RNA small subunit methyltransferase G
I7827_RS02655	COG0445	tRNA wobble uridine modification
I7827_RS02660	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I7827_RS02670	COG0594	ribonuclease P activity
I7827_RS02680	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I7827_RS02685	COG0592	DNA-directed DNA polymerase activity
I7827_RS02695	COG4152	abc transporter atp-binding protein
I7827_RS02700	COG1668	transmembrane transport
I7827_RS02705	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I7827_RS02710	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I7827_RS02715	COG2501	S4 domain
I7827_RS02720	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I7827_RS02730	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I7827_RS02735	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I7827_RS02745	COG2986	histidine ammonia-lyase
I7827_RS02755	COG1228	amidohydrolase
I7827_RS02760	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I7827_RS02780	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I7827_RS02790	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I7827_RS02795	COG0359	binds to the 23S rRNA
I7827_RS02800	COG0305	Participates in initiation and elongation during chromosome replication
I7827_RS02805	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I7827_RS02810	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I7827_RS02830	COG5002	protein histidine kinase activity
I7827_RS02845	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I7827_RS02850	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I7827_RS02875	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I7827_RS02875	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I7827_RS02940	COG1086	Polysaccharide biosynthesis protein
I7827_RS02950	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I7827_RS02980	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I7827_RS03010	COG0584	glycerophosphoryl diester phosphodiesterase
I7827_RS03015	COG2030	dehydratase
I7827_RS03040	COG1940	carbohydrate kinase activity
I7827_RS03040	COG1846	Transcriptional regulator
I7827_RS03050	COG2210	Belongs to the sulfur carrier protein TusA family
I7827_RS03055	COG1937	Protein conserved in bacteria
I7827_RS03060	COG0730	response to heat
I7827_RS03095	COG2003	Belongs to the UPF0758 family
I7827_RS03155	COG0730	response to heat
I7827_RS03160	COG1937	Protein conserved in bacteria
I7827_RS03165	COG2210	Belongs to the sulfur carrier protein TusA family
I7827_RS03170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I7827_RS03225	COG2226	methyltransferase
I7827_RS03260	COG1695	Transcriptional regulator
I7827_RS03280	COG2217	Heavy metal translocating P-type atpase
I7827_RS03285	COG1388	LysM domain
I7827_RS03295	COG0702	epimerase
I7827_RS03300	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
I7827_RS03335	COG0415	Belongs to the DNA photolyase family
I7827_RS03350	COG0730	response to heat
I7827_RS03355	COG1937	Protein conserved in bacteria
I7827_RS03360	COG2210	Belongs to the sulfur carrier protein TusA family
I7827_RS03365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I7827_RS03375	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I7827_RS03380	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I7827_RS03390	COG0446	pyridine nucleotide-disulphide oxidoreductase
I7827_RS03410	COG0640	Transcriptional regulator
I7827_RS03425	COG1486	melibiose metabolic process
I7827_RS03430	COG2211	Major facilitator Superfamily
I7827_RS03450	COG1064	alcohol dehydrogenase
I7827_RS03470	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I7827_RS03515	COG0642	Histidine kinase
I7827_RS03535	COG3711	transcriptional antiterminator
I7827_RS03540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7827_RS03540	COG1263	PTS System
I7827_RS03545	COG2723	6-phospho-beta-galactosidase activity
I7827_RS03550	COG2807	transmembrane transport
I7827_RS03555	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I7827_RS03585	COG2801	Transposase and inactivated derivatives
I7827_RS03590	COG0454	-acetyltransferase
I7827_RS03595	COG0556	nucleotide-excision repair
I7827_RS03600	COG0494	nUDIX hydrolase
I7827_RS03605	COG3290	protein histidine kinase activity
I7827_RS03610	COG4565	transcriptional regulatory protein
I7827_RS03615	COG3493	citrate carrier protein
I7827_RS03630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I7827_RS03635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I7827_RS03640	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I7827_RS03645	COG0019	diaminopimelate decarboxylase activity
I7827_RS03655	COG4264	IucA IucC family
I7827_RS03660	COG4264	IucA IucC family
I7827_RS03670	COG0702	epimerase
I7827_RS03675	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
I7827_RS03695	COG2801	Transposase and inactivated derivatives
I7827_RS03710	COG1114	Component of the transport system for branched-chain amino acids
I7827_RS03720	COG0183	Belongs to the thiolase family
I7827_RS03725	COG3425	synthase
I7827_RS03730	COG0477	Major facilitator Superfamily
I7827_RS03735	COG0584	glycerophosphoryl diester phosphodiesterase
I7827_RS03745	COG1846	Transcriptional regulator
I7827_RS03760	COG0531	amino acid
I7827_RS03765	COG1940	carbohydrate kinase activity
I7827_RS03765	COG1846	Transcriptional regulator
I7827_RS03770	COG2115	Belongs to the xylose isomerase family
I7827_RS03775	COG1070	Carbohydrate kinase
I7827_RS03780	COG2814	Major facilitator Superfamily
I7827_RS03780	COG0477	Major facilitator Superfamily
I7827_RS03790	COG1028	Short-chain dehydrogenase reductase Sdr
I7827_RS03795	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I7827_RS03800	COG0157	Belongs to the NadC ModD family
I7827_RS03805	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I7827_RS03810	COG1104	cysteine desulfurase activity
I7827_RS03815	COG1827	regulation of RNA biosynthetic process
I7827_RS03825	COG2318	DinB family
I7827_RS03830	COG2851	Citrate transporter
I7827_RS03835	COG1054	Belongs to the UPF0176 family
I7827_RS03855	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I7827_RS03875	COG0083	homoserine kinase activity
I7827_RS03880	COG3386	PFAM SMP-30 Gluconolaconase
I7827_RS03885	COG1304	FMN binding
I7827_RS03925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I7827_RS03930	COG1028	Short-chain dehydrogenase reductase Sdr
I7827_RS03940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I7827_RS03940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I7827_RS03940	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I7827_RS03945	COG3711	transcriptional antiterminator
I7827_RS03945	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I7827_RS03955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I7827_RS03970	COG0579	oxidoreductase
I7827_RS03980	COG0318	PFAM AMP-dependent synthetase and ligase
I7827_RS03985	COG1960	acyl-CoA dehydrogenase activity
I7827_RS03990	COG1250	3-hydroxyacyl-CoA dehydrogenase
I7827_RS03990	COG1024	Enoyl-CoA hydratase
I7827_RS03995	COG0183	Belongs to the thiolase family
I7827_RS04000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I7827_RS04005	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I7827_RS04010	COG3002	Belongs to the UPF0753 family
I7827_RS04015	COG0288	reversible hydration of carbon dioxide
I7827_RS04020	COG5609	conserved protein (DUF2294)
I7827_RS04025	COG1283	sodium-dependent phosphate transmembrane transporter activity
I7827_RS04030	COG0673	inositol 2-dehydrogenase activity
I7827_RS04040	COG0673	inositol 2-dehydrogenase activity
I7827_RS04060	COG2226	methyltransferase
I7827_RS04065	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
I7827_RS04080	COG0733	neurotransmitter:sodium symporter activity
I7827_RS04085	COG0583	DNA-binding transcription factor activity
I7827_RS04090	COG1380	Effector of murein hydrolase LrgA
I7827_RS04095	COG1346	cytolysis
I7827_RS04105	COG0175	sulfate reduction
I7827_RS04110	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I7827_RS04115	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I7827_RS04135	COG0730	response to heat
I7827_RS04140	COG2046	Belongs to the sulfate adenylyltransferase family
I7827_RS04145	COG0529	Catalyzes the synthesis of activated sulfate
I7827_RS04150	COG1510	regulation of RNA biosynthetic process
I7827_RS04155	COG1012	belongs to the aldehyde dehydrogenase family
I7827_RS04170	COG0659	secondary active sulfate transmembrane transporter activity
I7827_RS04195	COG3732	PTS system glucitol sorbitol-specific
I7827_RS04200	COG1063	alcohol dehydrogenase
I7827_RS04205	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I7827_RS04225	COG1247	-acetyltransferase
I7827_RS04235	COG0668	transmembrane transport
I7827_RS04240	COG2851	Citrate transporter
I7827_RS04245	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I7827_RS04265	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I7827_RS04270	COG1113	amino acid transport
I7827_RS04275	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I7827_RS04280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I7827_RS04285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I7827_RS04295	COG0477	Major facilitator Superfamily
I7827_RS04300	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I7827_RS04320	COG2205	protein histidine kinase activity
I7827_RS04325	COG0745	RESPONSE REGULATOR receiver
I7827_RS04330	COG2311	Membrane
I7827_RS04345	COG3961	Belongs to the TPP enzyme family
I7827_RS04365	COG1063	alcohol dehydrogenase
I7827_RS04375	COG1063	alcohol dehydrogenase
I7827_RS04380	COG3775	system Galactitol-specific IIC component
I7827_RS04385	COG3414	Phosphotransferase system galactitol-specific IIB component
I7827_RS04400	COG0531	amino acid
I7827_RS04410	COG1464	Belongs to the NlpA lipoprotein family
I7827_RS04415	COG2271	Major facilitator Superfamily
I7827_RS04440	COG0531	amino acid
I7827_RS04445	COG2130	NADP-dependent
I7827_RS04460	COG2188	Transcriptional regulator
I7827_RS04465	COG2222	sugar isomerase
I7827_RS04470	COG1105	Belongs to the carbohydrate kinase PfkB family
I7827_RS04475	COG3684	Belongs to the aldolase LacD family
I7827_RS04485	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7827_RS04485	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I7827_RS04490	COG3715	PTS system
I7827_RS04495	COG3716	PTS system mannose fructose sorbose family IID component
I7827_RS04515	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I7827_RS04520	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I7827_RS04525	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I7827_RS04545	COG1316	TRANSCRIPTIONal
I7827_RS04555	COG3001	Fructosamine kinase
I7827_RS04560	COG0662	Cupin 2, conserved barrel domain protein
I7827_RS04565	COG2807	transmembrane transport
I7827_RS04570	COG1113	amino acid transport
I7827_RS04580	COG3620	sequence-specific DNA binding
I7827_RS04600	COG0488	(ABC) transporter
I7827_RS04625	COG2084	Dehydrogenase
I7827_RS04635	COG2610	gluconate transmembrane transporter activity
I7827_RS04650	COG4336	lyase activity
I7827_RS04655	COG3275	phosphorelay sensor kinase activity
I7827_RS04660	COG3279	Response regulator of the LytR AlgR family
I7827_RS04665	COG1380	Effector of murein hydrolase LrgA
I7827_RS04670	COG1346	cytolysis
I7827_RS04680	COG3844	kynureninase activity
I7827_RS04685	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
I7827_RS04700	COG3639	organic phosphonate transmembrane transporter activity
I7827_RS04705	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I7827_RS04715	COG0737	Belongs to the 5'-nucleotidase family
I7827_RS04730	COG2188	Transcriptional regulator
I7827_RS04735	COG2190	(PTS) system
I7827_RS04735	COG1263	PTS System
I7827_RS04735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7827_RS04740	COG2723	6-phospho-beta-galactosidase activity
I7827_RS04790	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I7827_RS04795	COG1280	lysine exporter protein (LysE YggA)
I7827_RS04800	COG1132	(ABC) transporter
I7827_RS04805	COG1132	(ABC) transporter
I7827_RS04815	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
I7827_RS04820	COG3189	MarR family transcriptional regulator
I7827_RS04825	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I7827_RS04830	COG2022	thiamine diphosphate biosynthetic process
I7827_RS04840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I7827_RS04845	COG0352	thiamine-phosphate diphosphorylase activity
I7827_RS04880	COG4509	Sortase family
I7827_RS04905	COG3279	Response regulator of the LytR AlgR family
I7827_RS04915	COG1733	regulation of RNA biosynthetic process
I7827_RS04920	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I7827_RS04935	COG1380	Effector of murein hydrolase LrgA
I7827_RS04945	COG1278	Cold shock
I7827_RS04955	COG0833	amino acid
I7827_RS04960	COG2040	homocysteine
I7827_RS04965	COG1012	belongs to the aldehyde dehydrogenase family
I7827_RS04970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I7827_RS04980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I7827_RS04985	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I7827_RS04990	COG1869	D-ribose catabolic process
I7827_RS05010	COG0738	Major facilitator superfamily
I7827_RS05015	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I7827_RS05045	COG0656	L-ascorbic acid biosynthetic process
I7827_RS05050	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I7827_RS05055	COG3759	membrane
I7827_RS05060	COG2409	Drug exporters of the RND superfamily
I7827_RS05070	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I7827_RS05080	COG1737	Transcriptional regulator
I7827_RS05090	COG1316	TRANSCRIPTIONal
I7827_RS05095	COG2207	Transcriptional regulator
I7827_RS05115	COG0582	viral genome integration into host DNA
I7827_RS05120	COG2111	Na H antiporter
I7827_RS05120	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I7827_RS05125	COG2111	Na H antiporter
I7827_RS05130	COG1006	Multisubunit Na H antiporter MnhC subunit
I7827_RS05140	COG1863	multisubunit Na H antiporter MnhE subunit
I7827_RS05145	COG2212	antiporter activity
I7827_RS05150	COG1320	monovalent cation:proton antiporter activity
I7827_RS05160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I7827_RS05170	COG1321	iron dependent repressor
I7827_RS05185	COG1132	(ABC) transporter
I7827_RS05190	COG1620	l-lactate permease
I7827_RS05195	COG0039	L-malate dehydrogenase activity
I7827_RS05200	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I7827_RS05205	COG1120	ATPase activity
I7827_RS05210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I7827_RS05215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I7827_RS05230	COG1302	Protein conserved in bacteria
I7827_RS05235	COG2814	Major facilitator Superfamily
I7827_RS05240	COG3314	Sporulation integral membrane protein YlbJ
I7827_RS05245	COG2329	Antibiotic biosynthesis monooxygenase
I7827_RS05250	COG0300	oxidoreductase activity
I7827_RS05265	COG2962	Rard protein
I7827_RS05280	COG1988	membrane-bound metal-dependent
I7827_RS05295	COG1272	protein, Hemolysin III
I7827_RS05310	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I7827_RS05325	COG2814	Major facilitator Superfamily
I7827_RS05330	COG0489	protein tyrosine kinase activity
I7827_RS05335	COG2194	sulfuric ester hydrolase activity
I7827_RS05400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I7827_RS05410	COG1937	Protein conserved in bacteria
I7827_RS05415	COG2217	Heavy metal translocating P-type atpase
I7827_RS05420	COG0586	Pfam SNARE associated Golgi protein
I7827_RS05425	COG0456	acetyltransferase
I7827_RS05430	COG2514	catechol 2,3-dioxygenase activity
I7827_RS05435	COG1119	ATPase activity
I7827_RS05440	COG0561	phosphatase activity
I7827_RS05460	COG0702	epimerase
I7827_RS05480	COG0640	Transcriptional regulator
I7827_RS05495	COG0477	Major facilitator Superfamily
I7827_RS05515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I7827_RS05525	COG2205	protein histidine kinase activity
I7827_RS05530	COG1136	(ABC) transporter
I7827_RS05535	COG0577	efflux transmembrane transporter activity
I7827_RS05540	COG1392	Phosphate transport regulator
I7827_RS05545	COG0306	phosphate transporter
I7827_RS05550	COG1388	LysM domain
I7827_RS05550	COG3942	CHAP domain
I7827_RS05555	COG0670	Belongs to the BI1 family
I7827_RS05560	COG0217	transcriptional regulatory protein
I7827_RS05570	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I7827_RS05585	COG1566	PFAM secretion protein HlyD family protein
I7827_RS05590	COG2814	Major facilitator Superfamily
I7827_RS05605	COG0583	DNA-binding transcription factor activity
I7827_RS05610	COG2258	MOSC domain
I7827_RS05620	COG2839	Protein conserved in bacteria
I7827_RS05625	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I7827_RS05640	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I7827_RS05645	COG1447	Phosphotransferase system cellobiose-specific component IIA
I7827_RS05650	COG4221	oxidoreductase activity
I7827_RS05655	COG0788	formyltetrahydrofolate deformylase activity
I7827_RS05660	COG0598	Magnesium transport protein CorA
I7827_RS05665	COG1940	carbohydrate kinase activity
I7827_RS05680	COG0778	Nitroreductase
I7827_RS05690	COG2814	Major facilitator Superfamily
I7827_RS05695	COG1733	regulation of RNA biosynthetic process
I7827_RS05700	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I7827_RS05720	COG1757	Na H antiporter
I7827_RS05725	COG0004	ammonium transporteR
I7827_RS05730	COG1473	amidohydrolase
I7827_RS05740	COG2814	Major facilitator Superfamily
I7827_RS05745	COG0753	catalase activity
I7827_RS05760	COG3048	D-serine ammonia-lyase activity
I7827_RS05765	COG1966	Carbon starvation protein
I7827_RS05770	COG3383	formate dehydrogenase (NAD+) activity
I7827_RS05790	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I7827_RS05800	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I7827_RS05805	COG2011	ABC-type metal ion transport system permease component
I7827_RS05810	COG1464	Belongs to the NlpA lipoprotein family
I7827_RS05825	COG3942	CHAP domain
I7827_RS05830	COG1757	Na H antiporter
I7827_RS05835	COG3942	CHAP domain
I7827_RS05895	COG1131	(ABC) transporter
I7827_RS05900	COG1823	symporter activity
I7827_RS05905	COG1960	acyl-CoA dehydrogenase activity
I7827_RS05910	COG0697	spore germination
I7827_RS05915	COG2832	Protein of unknown function (DUF454)
I7827_RS05920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I7827_RS05925	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I7827_RS05935	COG2186	Transcriptional regulator
I7827_RS05940	COG2186	Transcriptional regulator
I7827_RS05950	COG1268	BioY protein
I7827_RS05960	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I7827_RS05975	COG4149	molybdate abc transporter
I7827_RS05980	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
I7827_RS05985	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I7827_RS05990	COG1140	nitrate reductase beta subunit
I7827_RS05995	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I7827_RS06000	COG2181	nitrate reductase activity
I7827_RS06010	COG4585	Histidine kinase
I7827_RS06015	COG2197	response regulator
I7827_RS06020	COG2223	nitrite transmembrane transporter activity
I7827_RS06025	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I7827_RS06030	COG0521	Mo-molybdopterin cofactor biosynthetic process
I7827_RS06035	COG0315	cyclic pyranopterin monophosphate synthase activity
I7827_RS06040	COG0303	'Molybdopterin
I7827_RS06045	COG1763	Mo-molybdopterin cofactor biosynthetic process
I7827_RS06060	COG0746	molybdenum cofactor guanylyltransferase activity
I7827_RS06065	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I7827_RS06070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I7827_RS06075	COG2814	Major facilitator Superfamily
I7827_RS06085	COG2348	transferase activity, transferring amino-acyl groups
I7827_RS06090	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I7827_RS06095	COG0436	Aminotransferase
I7827_RS06110	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I7827_RS06125	COG4975	Glucose uptake
I7827_RS06140	COG2252	PERMEase
I7827_RS06150	COG0051	transcription antitermination factor activity, RNA binding
I7827_RS06155	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I7827_RS06160	COG0088	Forms part of the polypeptide exit tunnel
I7827_RS06165	COG0089	rRNA binding
I7827_RS06170	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I7827_RS06175	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I7827_RS06180	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I7827_RS06185	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I7827_RS06190	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I7827_RS06195	COG0255	Belongs to the universal ribosomal protein uL29 family
I7827_RS06205	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I7827_RS06210	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I7827_RS06215	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I7827_RS06220	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I7827_RS06225	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I7827_RS06230	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I7827_RS06235	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I7827_RS06240	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I7827_RS06245	COG1841	ribosomal large subunit assembly
I7827_RS06255	COG0201	protein transport
I7827_RS06270	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I7827_RS06275	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I7827_RS06285	COG0202	RNA polymerase activity
I7827_RS06290	COG0203	ribosomal protein L17
I7827_RS06295	COG1122	ATPase activity
I7827_RS06310	COG0101	tRNA pseudouridine synthase activity
I7827_RS06315	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I7827_RS06320	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I7827_RS06325	COG1011	Hydrolase
I7827_RS06335	COG3655	Transcriptional regulator
I7827_RS06340	COG0346	lactoylglutathione lyase activity
I7827_RS06365	COG0604	alcohol dehydrogenase
I7827_RS06370	COG1511	domain protein
I7827_RS06380	COG3842	ATPase activity
I7827_RS06385	COG2182	Extracellular solute-binding protein
I7827_RS06390	COG1175	transmembrane transport
I7827_RS06395	COG3833	ABC-type maltose transport systems, permease component
I7827_RS06400	COG1609	Transcriptional regulator
I7827_RS06405	COG0366	Alpha amylase catalytic
I7827_RS06410	COG2376	Dihydroxyacetone kinase
I7827_RS06415	COG1461	Dihydroxyacetone kinase
I7827_RS06420	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I7827_RS06425	COG2186	Transcriptional regulator
I7827_RS06430	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I7827_RS06435	COG1482	cell wall glycoprotein biosynthetic process
I7827_RS06445	COG3942	CHAP domain
I7827_RS06445	COG1388	LysM domain
I7827_RS06455	COG1115	amino acid carrier protein
I7827_RS06465	COG1757	Na H antiporter
I7827_RS06475	COG1609	Transcriptional regulator
I7827_RS06480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I7827_RS06485	COG1869	D-ribose catabolic process
I7827_RS06490	COG1129	ABC transporter
I7827_RS06495	COG1172	Belongs to the binding-protein-dependent transport system permease family
I7827_RS06500	COG1879	ABC-type sugar transport system periplasmic component
I7827_RS06505	COG0783	Belongs to the Dps family
I7827_RS06510	COG0277	FAD linked oxidase domain protein
I7827_RS06515	COG0247	lactate metabolic process
I7827_RS06520	COG0813	purine-nucleoside phosphorylase activity
I7827_RS06525	COG2390	Transcriptional regulator
I7827_RS06530	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I7827_RS06540	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I7827_RS06550	COG1854	S-ribosylhomocysteine lyase activity
I7827_RS06555	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I7827_RS06555	COG0456	acetyltransferase
I7827_RS06595	COG5146	pantothenate kinase activity
I7827_RS06600	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I7827_RS06605	COG4589	Belongs to the CDS family
I7827_RS06625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I7827_RS06630	COG3343	RNA polymerase activity
I7827_RS06635	COG0504	CTP synthase activity
I7827_RS06640	COG4821	SIS domain
I7827_RS06645	COG0745	RESPONSE REGULATOR receiver
I7827_RS06650	COG0191	fructose-bisphosphate aldolase activity
I7827_RS06655	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I7827_RS06665	COG1012	belongs to the aldehyde dehydrogenase family
I7827_RS06670	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I7827_RS06675	COG0254	rRNA binding
I7827_RS06680	COG1435	thymidine kinase activity
I7827_RS06690	COG2890	protein-(glutamine-N5) methyltransferase activity
I7827_RS06695	COG0009	L-threonylcarbamoyladenylate synthase
I7827_RS06700	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I7827_RS06705	COG0698	ribose 5-phosphate isomerase
I7827_RS06710	COG4475	Protein of unknown function (DUF436)
I7827_RS06715	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I7827_RS06720	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I7827_RS06725	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I7827_RS06735	COG0356	it plays a direct role in the translocation of protons across the membrane
I7827_RS06740	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I7827_RS06745	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I7827_RS06750	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I7827_RS06755	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I7827_RS06760	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I7827_RS06765	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I7827_RS06790	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I7827_RS06800	COG0629	single-stranded DNA binding
I7827_RS06805	COG1388	LysM domain
I7827_RS06815	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I7827_RS06820	COG0352	thiamine-phosphate diphosphorylase activity
I7827_RS06825	COG0706	membrane insertase activity
I7827_RS06830	COG1418	mRNA catabolic process
I7827_RS06835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I7827_RS06845	COG0772	Belongs to the SEDS family
I7827_RS06850	COG1181	Belongs to the D-alanine--D-alanine ligase family
I7827_RS06855	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I7827_RS06865	COG0513	Belongs to the DEAD box helicase family
I7827_RS06905	COG2208	phosphoserine phosphatase activity
I7827_RS06920	COG1191	sigma factor activity
I7827_RS06925	COG2183	response to ionizing radiation
I7827_RS06930	COG3091	SprT-like family
I7827_RS06960	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I7827_RS06970	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I7827_RS06975	COG0473	3-isopropylmalate dehydrogenase activity
I7827_RS06980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I7827_RS06985	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I7827_RS06995	COG0028	Belongs to the TPP enzyme family
I7827_RS07000	COG0129	dihydroxy-acid dehydratase activity
I7827_RS07005	COG0802	atpase or kinase
I7827_RS07010	COG1214	PFAM Peptidase M22, glycoprotease
I7827_RS07015	COG0456	acetyltransferase
I7827_RS07020	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I7827_RS07035	COG0488	(ABC) transporter
I7827_RS07040	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I7827_RS07045	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I7827_RS07050	COG0805	protein transport
I7827_RS07055	COG2391	methyltransferase activity
I7827_RS07060	COG0425	Belongs to the sulfur carrier protein TusA family
I7827_RS07065	COG1609	Transcriptional regulator
I7827_RS07070	COG1621	beta-fructofuranosidase activity
I7827_RS07105	COG0459	protein refolding
I7827_RS07115	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I7827_RS07140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I7827_RS07145	COG1131	(ABC) transporter
I7827_RS07160	COG1131	(ABC) transporter
I7827_RS07175	COG1473	amidohydrolase
I7827_RS07185	COG1070	Carbohydrate kinase
I7827_RS07190	COG2610	gluconate transmembrane transporter activity
I7827_RS07195	COG2223	nitrite transmembrane transporter activity
I7827_RS07225	COG0385	Bile acid
I7827_RS07265	COG4512	PFAM Accessory gene regulator B
I7827_RS07270	COG2706	6-phosphogluconolactonase activity
I7827_RS07275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I7827_RS07280	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I7827_RS07285	COG0390	transport system, permease component
I7827_RS07290	COG1012	belongs to the aldehyde dehydrogenase family
I7827_RS07295	COG0673	inositol 2-dehydrogenase activity
I7827_RS07310	COG1227	inorganic diphosphatase activity
I7827_RS07315	COG1335	isochorismatase
I7827_RS07330	COG0077	Prephenate dehydratase
I7827_RS07345	COG0107	imidazoleglycerol-phosphate synthase activity
I7827_RS07350	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I7827_RS07355	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I7827_RS07360	COG0131	Imidazoleglycerol-phosphate dehydratase
I7827_RS07365	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I7827_RS07370	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I7827_RS07375	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I7827_RS07380	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I7827_RS07385	COG0477	Major facilitator Superfamily
I7827_RS07390	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I7827_RS07395	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I7827_RS07400	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
I7827_RS07410	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I7827_RS07415	COG4496	protein, YerC YecD
I7827_RS07420	COG1876	peptidase activity
I7827_RS07425	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
I7827_RS07430	COG0210	DNA helicase
I7827_RS07435	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I7827_RS07440	COG4851	CamS sex pheromone cAM373 precursor
I7827_RS07445	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I7827_RS07450	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I7827_RS07460	COG0154	amidase activity
I7827_RS07465	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I7827_RS07470	COG0433	COG0433 Predicted ATPase
I7827_RS07475	COG1597	lipid kinase activity
I7827_RS07495	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I7827_RS07510	COG1528	Iron-storage protein
I7827_RS07525	COG4129	membrane
I7827_RS07530	COG0024	Methionine aminopeptidase
I7827_RS07550	COG2197	response regulator
I7827_RS07555	COG0288	reversible hydration of carbon dioxide
I7827_RS07560	COG1295	ribonuclease BN
I7827_RS07575	COG4840	Belongs to the UPF0435 family
I7827_RS07580	COG2309	aminopeptidase activity
I7827_RS07590	COG1607	acyl-coa hydrolase
I7827_RS07595	COG0535	radical SAM domain protein
I7827_RS07605	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I7827_RS07610	COG0693	protein deglycase activity
I7827_RS07620	COG0028	Belongs to the TPP enzyme family
I7827_RS07625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I7827_RS07630	COG2137	regulation of response to DNA damage stimulus
I7827_RS07640	COG1134	teichoic acid transport
I7827_RS07650	COG1988	membrane-bound metal-dependent
I7827_RS07655	COG1194	a g-specific adenine glycosylase
I7827_RS07660	COG3557	Belongs to the UPF0374 family
I7827_RS07670	COG0069	glutamate synthase activity
I7827_RS07675	COG4129	membrane
I7827_RS07680	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I7827_RS07685	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I7827_RS07695	COG0735	belongs to the Fur family
I7827_RS07850	COG1609	Transcriptional regulator
I7827_RS07880	COG1904	glucuronate isomerase
I7827_RS07895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I7827_RS07900	COG0765	amino acid transport
I7827_RS07905	COG1126	abc transporter atp-binding protein
I7827_RS07910	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I7827_RS07915	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I7827_RS07920	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I7827_RS07925	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I7827_RS07930	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I7827_RS07940	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I7827_RS07945	COG0363	glucosamine-6-phosphate deaminase activity
I7827_RS07955	COG0114	fumarate hydratase activity
I7827_RS07965	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I7827_RS07970	COG0564	pseudouridine synthase activity
I7827_RS07975	COG3153	acetyltransferase
I7827_RS07975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I7827_RS07980	COG4585	Histidine kinase
I7827_RS07980	COG2203	Gaf domain
I7827_RS07985	COG2197	response regulator
I7827_RS08000	COG4399	Belongs to the UPF0754 family
I7827_RS08005	COG3679	Belongs to the UPF0342 family
I7827_RS08010	COG0420	3'-5' exonuclease activity
I7827_RS08020	COG3481	metal-dependent phosphohydrolase, HD sub domain
I7827_RS08025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I7827_RS08035	COG1846	Transcriptional regulator
I7827_RS08045	COG0537	adenosine 5'-monophosphoramidase activity
I7827_RS08050	COG1131	(ABC) transporter
I7827_RS08060	COG2329	Antibiotic biosynthesis monooxygenase
I7827_RS08065	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I7827_RS08070	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I7827_RS08075	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I7827_RS08130	COG1051	belongs to the nudix hydrolase family
I7827_RS08145	COG2176	DNA-directed DNA polymerase activity
I7827_RS08155	COG0697	spore germination
I7827_RS08160	COG0456	acetyltransferase
I7827_RS08170	COG2814	Major facilitator Superfamily
I7827_RS08195	COG0494	nUDIX hydrolase
I7827_RS08200	COG1506	peptidase
I7827_RS08205	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I7827_RS08210	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I7827_RS08220	COG1012	belongs to the aldehyde dehydrogenase family
I7827_RS08225	COG0656	L-ascorbic acid biosynthetic process
I7827_RS08230	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I7827_RS08250	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I7827_RS08255	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I7827_RS08275	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I7827_RS08300	COG1595	DNA-templated transcription, initiation
I7827_RS08345	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I7827_RS08345	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I7827_RS08350	COG0307	riboflavin synthase, alpha
I7827_RS08380	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I7827_RS08385	COG2267	carboxylic ester hydrolase activity
I7827_RS08395	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I7827_RS08400	COG1242	4 iron, 4 sulfur cluster binding
I7827_RS08405	COG2814	Major facilitator Superfamily
I7827_RS08410	COG0495	leucyl-tRNA aminoacylation
I7827_RS08415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I7827_RS08420	COG2081	HI0933 family
I7827_RS08425	COG2244	polysaccharide biosynthetic process
I7827_RS08430	COG1187	pseudouridine synthase activity
I7827_RS08450	COG0510	thiamine kinase activity
I7827_RS08455	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I7827_RS08460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I7827_RS08465	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I7827_RS08475	COG1363	Peptidase, m42
I7827_RS08480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I7827_RS08485	COG0765	amino acid transport
I7827_RS08490	COG1126	abc transporter atp-binding protein
I7827_RS08500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I7827_RS08505	COG4848	Belongs to the UPF0354 family
I7827_RS08510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I7827_RS08515	COG1674	ftsk spoiiie
I7827_RS08520	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I7827_RS08525	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
I7827_RS08530	COG4980	gas vesicle protein
I7827_RS08535	COG1605	Chorismate mutase
I7827_RS08535	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I7827_RS08540	COG1609	Transcriptional regulator
I7827_RS08545	COG0123	including yeast histone deacetylase and acetoin utilization protein
I7827_RS08550	COG0517	IMP dehydrogenase activity
I7827_RS08555	COG0454	-acetyltransferase
I7827_RS08560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I7827_RS08565	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I7827_RS08570	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I7827_RS08575	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I7827_RS08580	COG1704	LemA family
I7827_RS08590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I7827_RS08595	COG0204	Acyl-transferase
I7827_RS08610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I7827_RS08620	COG1764	response to oxidative stress
I7827_RS08630	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I7827_RS08635	COG1956	GAF domain-containing protein
I7827_RS08640	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I7827_RS08645	COG1104	cysteine desulfurase activity
I7827_RS08650	COG0301	tRNA thio-modification
I7827_RS08660	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I7827_RS08665	COG0616	signal peptide processing
I7827_RS08670	COG1714	RDD family
I7827_RS08675	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I7827_RS08680	COG0827	DNA restriction-modification system
I7827_RS08685	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I7827_RS08700	COG0589	response to stress
I7827_RS08705	COG0686	Belongs to the AlaDH PNT family
I7827_RS08715	COG3142	Participates in the control of copper homeostasis
I7827_RS08720	COG0006	proline dipeptidase activity
I7827_RS08725	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I7827_RS08730	COG4109	DRTGG domain
I7827_RS08740	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I7827_RS08745	COG0587	DNA-directed DNA polymerase activity
I7827_RS08750	COG0281	malic enzyme
I7827_RS08755	COG1725	Transcriptional regulator
I7827_RS08760	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I7827_RS08765	COG0825	malonyl-CoA metabolic process
I7827_RS08770	COG0205	6-phosphofructokinase activity
I7827_RS08775	COG0469	pyruvate kinase activity
I7827_RS08780	COG1113	amino acid transport
I7827_RS08785	COG0372	Belongs to the citrate synthase family
I7827_RS08790	COG0538	isocitrate dehydrogenase activity
I7827_RS08800	COG0745	RESPONSE REGULATOR receiver
I7827_RS08805	COG5002	protein histidine kinase activity
I7827_RS08810	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I7827_RS08810	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I7827_RS08815	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I7827_RS08820	COG0237	dephospho-CoA kinase activity
I7827_RS08825	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I7827_RS08835	COG3611	Membrane attachment protein
I7827_RS08840	COG1484	DNA-dependent DNA replication
I7827_RS08850	COG0833	amino acid
I7827_RS08855	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I7827_RS08860	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I7827_RS08865	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I7827_RS08870	COG4112	unkown
I7827_RS08880	COG0544	peptidyl-prolyl cis-trans isomerase activity
I7827_RS08885	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I7827_RS08890	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I7827_RS08895	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I7827_RS08900	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I7827_RS08905	COG0181	hydroxymethylbilane synthase activity
I7827_RS08915	COG0113	porphobilinogen synthase activity
I7827_RS08920	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I7827_RS08935	COG0285	dihydrofolate synthase activity
I7827_RS08940	COG1288	antiporter activity
I7827_RS08945	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I7827_RS08970	COG2249	NAD(P)H dehydrogenase (quinone) activity
I7827_RS08975	COG0477	Major facilitator Superfamily
I7827_RS08985	COG2003	Belongs to the UPF0758 family
I7827_RS08995	COG0488	(ABC) transporter
I7827_RS09010	COG1132	(ABC) transporter
I7827_RS09015	COG1132	(ABC) transporter
I7827_RS09025	COG1792	Involved in formation and maintenance of cell shape
I7827_RS09035	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I7827_RS09040	COG2868	ribosomal protein
I7827_RS09045	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I7827_RS09055	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I7827_RS09060	COG4492	Belongs to the UPF0735 family
I7827_RS09065	COG0632	four-way junction helicase activity
I7827_RS09070	COG2255	four-way junction helicase activity
I7827_RS09080	COG0343	queuine tRNA-ribosyltransferase activity
I7827_RS09085	COG1862	Preprotein translocase
I7827_RS09090	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I7827_RS09090	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I7827_RS09095	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I7827_RS09095	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I7827_RS09105	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I7827_RS09115	COG0860	N-Acetylmuramoyl-L-alanine amidase
I7827_RS09120	COG0124	histidyl-tRNA synthetase
I7827_RS09125	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I7827_RS09135	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I7827_RS09140	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I7827_RS09145	COG1959	2 iron, 2 sulfur cluster binding
I7827_RS09155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I7827_RS09160	COG0488	(ABC) transporter
I7827_RS09165	COG1104	cysteine desulfurase activity
I7827_RS09170	COG0482	sulfurtransferase activity
I7827_RS09180	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I7827_RS09185	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I7827_RS09190	COG4472	Bacterial protein of unknown function (DUF965)
I7827_RS09195	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I7827_RS09205	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I7827_RS09210	COG4122	O-methyltransferase activity
I7827_RS09215	COG0826	peptidase U32
I7827_RS09220	COG0826	peptidase U32
I7827_RS09225	COG0572	uridine kinase
I7827_RS09230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I7827_RS09235	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I7827_RS09240	COG1984	allophanate hydrolase subunit 2
I7827_RS09250	COG0439	Biotin carboxylase
I7827_RS09255	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I7827_RS09260	COG1914	H( )-stimulated, divalent metal cation uptake system
I7827_RS09265	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I7827_RS09270	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I7827_RS09275	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I7827_RS09280	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I7827_RS09285	COG1534	Rna-binding protein
I7827_RS09290	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I7827_RS09295	COG1713	HD superfamily hydrolase involved in NAD metabolism
I7827_RS09300	COG0799	negative regulation of ribosome biogenesis
I7827_RS09305	COG2226	methyltransferase
I7827_RS09310	COG1555	photosystem II stabilization
I7827_RS09310	COG1596	polysaccharide export
I7827_RS09315	COG2131	deaminase
I7827_RS09320	COG2333	competence protein COMEC
I7827_RS09320	COG0658	competence protein
I7827_RS09330	COG1466	dna polymerase III delta subunit
I7827_RS09335	COG0268	Binds directly to 16S ribosomal RNA
I7827_RS09340	COG0481	GTPase activity
I7827_RS09345	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I7827_RS09355	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I7827_RS09360	COG0443	Heat shock 70 kDa protein
I7827_RS09370	COG2264	protein methyltransferase activity
I7827_RS09375	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I7827_RS09380	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I7827_RS09385	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I7827_RS09390	COG1030	water channel activity
I7827_RS09395	COG4864	UPF0365 protein
I7827_RS09410	COG1702	phosphate starvation-inducible protein PhoH
I7827_RS09415	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I7827_RS09420	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I7827_RS09425	COG0295	cytidine deaminase activity
I7827_RS09435	COG1381	Involved in DNA repair and RecF pathway recombination
I7827_RS09440	COG0423	glycine-tRNA ligase activity
I7827_RS09445	COG0517	IMP dehydrogenase activity
I7827_RS09450	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I7827_RS09455	COG0358	DNA primase activity
I7827_RS09460	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I7827_RS09465	COG2010	Cytochrome c
I7827_RS09470	COG2384	SAM-dependent methyltransferase
I7827_RS09475	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I7827_RS09480	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I7827_RS09485	COG0513	Belongs to the DEAD box helicase family
I7827_RS09490	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I7827_RS09495	COG1121	(ABC) transporter
I7827_RS09500	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I7827_RS09505	COG0735	belongs to the Fur family
I7827_RS09510	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
I7827_RS09515	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I7827_RS09525	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I7827_RS09530	COG0768	penicillin binding
I7827_RS09535	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I7827_RS09540	COG0573	inorganic phosphate transmembrane transporter activity
I7827_RS09545	COG0581	inorganic phosphate transmembrane transporter activity
I7827_RS09550	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I7827_RS09555	COG0704	Plays a role in the regulation of phosphate uptake
I7827_RS09560	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I7827_RS09565	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I7827_RS09570	COG0457	Tetratricopeptide repeat
I7827_RS09570	COG0705	Rhomboid family
I7827_RS09575	COG4483	Protein conserved in bacteria
I7827_RS09580	COG1940	carbohydrate kinase activity
I7827_RS09585	COG0011	TIGRFAM Protein of
I7827_RS09595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I7827_RS09605	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I7827_RS09610	COG1459	type II secretion system
I7827_RS09640	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I7827_RS09645	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I7827_RS09655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I7827_RS09660	COG0095	Lipoate-protein ligase
I7827_RS09675	COG0006	proline dipeptidase activity
I7827_RS09680	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I7827_RS09685	COG0511	ligase activity, forming carbon-carbon bonds
I7827_RS09690	COG0439	Biotin carboxylase
I7827_RS09695	COG1302	Protein conserved in bacteria
I7827_RS09705	COG1570	exodeoxyribonuclease VII activity
I7827_RS09720	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I7827_RS09725	COG1438	arginine binding
I7827_RS09730	COG0497	DNA recombination
I7827_RS09745	COG0280	phosphate acetyltransferase
I7827_RS09755	COG3426	butyrate kinase activity
I7827_RS09760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I7827_RS09765	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I7827_RS09770	COG0022	dehydrogenase e1 component
I7827_RS09775	COG0508	dehydrogenase complex catalyzes the overall conversion of
I7827_RS09785	COG4129	membrane
I7827_RS09795	COG2195	Cleaves the N-terminal amino acid of tripeptides
I7827_RS09800	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I7827_RS09805	COG2207	Transcriptional regulator
I7827_RS09805	COG1917	Cupin 2, conserved barrel domain protein
I7827_RS09810	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I7827_RS09815	COG1234	tRNA 3'-trailer cleavage
I7827_RS09820	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I7827_RS09830	COG0667	Aldo Keto reductase
I7827_RS09840	COG0735	belongs to the Fur family
I7827_RS09845	COG4974	Belongs to the 'phage' integrase family
I7827_RS09850	COG1547	Domain of unknown function (DUF309)
I7827_RS09855	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I7827_RS09860	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I7827_RS09865	COG1187	pseudouridine synthase activity
I7827_RS09870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I7827_RS09875	COG1333	cytochrome c biogenesis protein
I7827_RS09880	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I7827_RS09885	COG0745	RESPONSE REGULATOR receiver
I7827_RS09890	COG5002	protein histidine kinase activity
I7827_RS09900	COG1141	Ferredoxin
I7827_RS09905	COG4955	Helix-turn-helix domain
I7827_RS09910	COG0514	ATP-dependent DNA helicase (RecQ)
I7827_RS09925	COG0492	ferredoxin-NADP+ reductase activity
I7827_RS09930	COG0252	asparaginase activity
I7827_RS09935	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I7827_RS09940	COG0539	negative regulation of cytoplasmic translation
I7827_RS09945	COG1160	GTP binding
I7827_RS09950	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I7827_RS09975	COG2226	methyltransferase
I7827_RS09980	COG0142	geranyltranstransferase activity
I7827_RS09985	COG0105	UTP biosynthetic process
I7827_RS09990	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I7827_RS09995	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I7827_RS10000	COG0457	Tetratricopeptide repeat
I7827_RS10015	COG0723	plastoquinol--plastocyanin reductase activity
I7827_RS10020	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I7827_RS10035	COG2738	Putative neutral zinc metallopeptidase
I7827_RS10040	COG1694	Mazg nucleotide pyrophosphohydrolase
I7827_RS10045	COG0438	transferase activity, transferring glycosyl groups
I7827_RS10050	COG0617	tRNA 3'-terminal CCA addition
I7827_RS10060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I7827_RS10060	COG1199	ATP-dependent helicase activity
I7827_RS10070	COG3935	DnaD domain protein
I7827_RS10075	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I7827_RS10085	COG4499	WXG100 protein secretion system (Wss), protein YukC
I7827_RS10085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I7827_RS10090	COG3331	DNA recombination
I7827_RS10100	COG4474	Belongs to the UPF0398 family
I7827_RS10105	COG3599	regulation of cell shape
I7827_RS10115	COG0116	Belongs to the methyltransferase superfamily
I7827_RS10120	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I7827_RS10130	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I7827_RS10135	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I7827_RS10140	COG0328	RNA-DNA hybrid ribonuclease activity
I7827_RS10160	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I7827_RS10170	COG1413	lyase activity
I7827_RS10195	COG0204	Acyl-transferase
I7827_RS10215	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I7827_RS10220	COG2190	(PTS) system
I7827_RS10225	COG4479	Belongs to the UPF0346 family
I7827_RS10230	COG0793	Belongs to the peptidase S41A family
I7827_RS10245	COG0671	phosphoesterase, PA-phosphatase related
I7827_RS10255	COG5002	protein histidine kinase activity
I7827_RS10260	COG0567	Dehydrogenase, E1 component
I7827_RS10270	COG2267	carboxylic ester hydrolase activity
I7827_RS10285	COG0714	Associated with various cellular activities
I7827_RS10290	COG4548	von Willebrand factor, type A
I7827_RS10295	COG1114	Component of the transport system for branched-chain amino acids
I7827_RS10300	COG5505	Protein of unknown function (DUF819)
I7827_RS10305	COG3853	Toxic anion resistance protein (TelA)
I7827_RS10315	COG1254	Belongs to the acylphosphatase family
I7827_RS10350	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I7827_RS10355	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I7827_RS10360	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I7827_RS10365	COG0527	aspartate kinase activity
I7827_RS10370	COG0488	(ABC) transporter
I7827_RS10375	COG2996	Protein conserved in bacteria
I7827_RS10380	COG3711	transcriptional antiterminator
I7827_RS10385	COG1447	Phosphotransferase system cellobiose-specific component IIA
I7827_RS10390	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I7827_RS10390	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I7827_RS10395	COG2723	6-phospho-beta-galactosidase activity
I7827_RS10400	COG3684	Belongs to the aldolase LacD family
I7827_RS10405	COG1105	Belongs to the carbohydrate kinase PfkB family
I7827_RS10410	COG0698	ribose 5-phosphate isomerase
I7827_RS10420	COG1349	DNA-binding transcription factor activity
I7827_RS10425	COG1164	Oligoendopeptidase f
I7827_RS10440	COG0789	Transcriptional regulator
I7827_RS10465	COG0159	tryptophan synthase activity
I7827_RS10470	COG0133	tryptophan synthase activity
I7827_RS10475	COG0135	phosphoribosylanthranilate isomerase activity
I7827_RS10485	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I7827_RS10495	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I7827_RS10500	COG1363	Peptidase, m42
I7827_RS10505	COG0287	Prephenate dehydrogenase
I7827_RS10515	COG1476	TRANSCRIPTIONal
I7827_RS10520	COG1757	Na H antiporter
I7827_RS10525	COG1929	Belongs to the glycerate kinase type-1 family
I7827_RS10530	COG0471	metal ion transport
I7827_RS10550	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I7827_RS10585	COG0586	Pfam SNARE associated Golgi protein
I7827_RS10590	COG0583	DNA-binding transcription factor activity
I7827_RS10605	COG0628	permease
I7827_RS10610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7827_RS10610	COG1263	PTS System
I7827_RS10610	COG2190	(PTS) system
I7827_RS10615	COG3711	transcriptional antiterminator
I7827_RS10625	COG1115	amino acid carrier protein
I7827_RS10630	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I7827_RS10640	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I7827_RS10645	COG4841	protein insertion into membrane
I7827_RS10650	COG0824	Thioesterase
I7827_RS10660	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I7827_RS10665	COG1970	mechanosensitive ion channel activity
I7827_RS10670	COG1999	signal sequence binding
I7827_RS10690	COG4846	Membrane protein involved in cytochrome C biogenesis
I7827_RS10695	COG0785	Cytochrome C biogenesis protein
I7827_RS10700	COG3763	UPF0154 protein
I7827_RS10710	COG4224	UPF0291 protein
I7827_RS10720	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I7827_RS10730	COG0516	GMP reductase activity
I7827_RS10735	COG0803	Belongs to the bacterial solute-binding protein 9 family
I7827_RS10740	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I7827_RS10745	COG0833	amino acid
I7827_RS10755	COG0446	pyridine nucleotide-disulphide oxidoreductase
I7827_RS10755	COG1902	pentaerythritol trinitrate reductase activity
I7827_RS10760	COG0640	Transcriptional regulator
I7827_RS10775	COG0561	phosphatase activity
I7827_RS10780	COG0083	homoserine kinase activity
I7827_RS10785	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I7827_RS10790	COG0460	homoserine dehydrogenase
I7827_RS10795	COG0527	aspartate kinase activity
I7827_RS10810	COG2084	Dehydrogenase
I7827_RS10820	COG1597	lipid kinase activity
I7827_RS10860	COG0110	maltose O-acetyltransferase activity
I7827_RS10875	COG0789	Transcriptional regulator
I7827_RS10880	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I7827_RS10885	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I7827_RS10890	COG0386	Belongs to the glutathione peroxidase family
I7827_RS10895	COG1923	regulation of RNA biosynthetic process
I7827_RS10900	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I7827_RS10905	COG2267	carboxylic ester hydrolase activity
I7827_RS10910	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I7827_RS10915	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I7827_RS10920	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I7827_RS10925	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I7827_RS10930	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I7827_RS10935	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I7827_RS10945	COG4550	Control of competence regulator ComK, YlbF/YmcA
I7827_RS10950	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I7827_RS10960	COG1132	(ABC) transporter
I7827_RS10965	COG1132	(ABC) transporter
I7827_RS10975	COG1013	pyruvate-flavodoxin oxidoreductase activity
I7827_RS10980	COG0674	pyruvate-flavodoxin oxidoreductase activity
I7827_RS10980	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I7827_RS10985	COG1692	metallophosphoesterase
I7827_RS10995	COG0463	Glycosyl transferase, family 2
I7827_RS10995	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I7827_RS11020	COG0500	methyltransferase
I7827_RS11025	COG0561	phosphatase activity
I7827_RS11030	COG1917	Cupin 2, conserved barrel domain protein
I7827_RS11030	COG2207	Transcriptional regulator
I7827_RS11035	COG0697	spore germination
I7827_RS11050	COG0596	Alpha beta hydrolase
I7827_RS11060	COG1418	mRNA catabolic process
I7827_RS11065	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I7827_RS11070	COG1058	Belongs to the CinA family
I7827_RS11070	COG1546	Belongs to the CinA family
I7827_RS11090	COG0300	oxidoreductase activity
I7827_RS11095	COG0612	Peptidase, M16
I7827_RS11105	COG2188	Transcriptional regulator
I7827_RS11115	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I7827_RS11120	COG0612	Peptidase, M16
I7827_RS11125	COG1185	polyribonucleotide nucleotidyltransferase activity
I7827_RS11135	COG0196	riboflavin kinase activity
I7827_RS11140	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I7827_RS11145	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I7827_RS11150	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I7827_RS11155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I7827_RS11155	COG1263	PTS System
I7827_RS11180	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I7827_RS11185	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I7827_RS11190	COG2169	Transcriptional regulator
I7827_RS11200	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I7827_RS11205	COG1358	cellular component organization or biogenesis
I7827_RS11210	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I7827_RS11215	COG0195	Participates in both transcription termination and antitermination
I7827_RS11220	COG0779	Required for maturation of 30S ribosomal subunits
I7827_RS11230	COG0442	prolyl-tRNA aminoacylation
I7827_RS11240	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I7827_RS11245	COG4589	Belongs to the CDS family
I7827_RS11255	COG0233	cytoplasmic translational termination
I7827_RS11260	COG0528	UMP kinase activity
I7827_RS11265	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I7827_RS11270	COG0052	Belongs to the universal ribosomal protein uS2 family
I7827_RS11280	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I7827_RS11285	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I7827_RS11290	COG4974	Belongs to the 'phage' integrase family
I7827_RS11295	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I7827_RS11300	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I7827_RS11305	COG0758	DNA mediated transformation
I7827_RS11315	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I7827_RS11320	COG0045	succinate-CoA ligase (ADP-forming) activity
I7827_RS11325	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I7827_RS11330	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I7827_RS11335	COG0463	Glycosyl transferase, family 2
I7827_RS11340	COG4485	Bacterial membrane protein, YfhO
I7827_RS11345	COG0335	large ribosomal subunit rRNA binding
I7827_RS11350	COG0336	Belongs to the RNA methyltransferase TrmD family
I7827_RS11360	COG1837	Belongs to the UPF0109 family
I7827_RS11365	COG0228	four-way junction DNA binding
I7827_RS11370	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I7827_RS11375	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I7827_RS11380	COG0552	protein localization to endoplasmic reticulum
I7827_RS11385	COG1196	nuclear chromosome segregation
I7827_RS11405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I7827_RS11420	COG0416	fatty acid biosynthetic process
I7827_RS11425	COG1349	DNA-binding transcription factor activity
I7827_RS11430	COG3764	Sortase (surface protein transpeptidase)
I7827_RS11435	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I7827_RS11440	COG1760	l-serine dehydratase
I7827_RS11445	COG1760	l-serine dehydratase
I7827_RS11455	COG1302	Protein conserved in bacteria
I7827_RS11460	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I7827_RS11465	COG1564	THIamine pyrophosphokinase
I7827_RS11470	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I7827_RS11475	COG1162	GTPase activity
I7827_RS11480	COG3850	Histidine kinase
I7827_RS11480	COG5002	protein histidine kinase activity
I7827_RS11485	COG0745	RESPONSE REGULATOR receiver
I7827_RS11490	COG2124	cytochrome p450
I7827_RS11510	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I7827_RS11515	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I7827_RS11515	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I7827_RS11520	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I7827_RS11525	COG0242	peptide deformylase activity
I7827_RS11540	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I7827_RS11545	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I7827_RS11550	COG1758	RNA polymerase activity
I7827_RS11570	COG0471	metal ion transport
I7827_RS11585	COG0284	orotidine-5'-phosphate decarboxylase activity
I7827_RS11590	COG0167	dihydroorotate dehydrogenase activity
I7827_RS11595	COG0543	2 iron, 2 sulfur cluster binding
I7827_RS11600	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I7827_RS11605	COG0505	Belongs to the CarA family
I7827_RS11615	COG0540	Belongs to the ATCase OTCase family
I7827_RS11625	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I7827_RS11630	COG0564	pseudouridine synthase activity
I7827_RS11635	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I7827_RS11660	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I7827_RS11665	COG3599	regulation of cell shape
I7827_RS11675	COG0762	integral membrane protein
I7827_RS11680	COG1799	cell septum assembly
I7827_RS11685	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I7827_RS11690	COG1496	oxidoreductase activity
I7827_RS11695	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I7827_RS11700	COG0849	cell division
I7827_RS11705	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I7827_RS11710	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I7827_RS11715	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I7827_RS11720	COG0768	penicillin binding
I7827_RS11725	COG4839	cell division protein FtsL
I7827_RS11730	COG0275	rRNA processing
I7827_RS11735	COG2001	Belongs to the MraZ family
I7827_RS11740	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
I7827_RS11745	COG0454	-acetyltransferase
I7827_RS11755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I7827_RS11760	COG0366	Alpha amylase catalytic
I7827_RS11775	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I7827_RS11775	COG0456	acetyltransferase
I7827_RS11800	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I7827_RS11810	COG1846	Transcriptional regulator
I7827_RS11815	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I7827_RS11820	COG1053	succinate dehydrogenase
I7827_RS11825	COG2009	succinate dehydrogenase
I7827_RS11830	COG0322	excinuclease ABC activity
I7827_RS11835	COG3118	belongs to the thioredoxin family
I7827_RS11840	COG1024	Enoyl-CoA hydratase
I7827_RS11850	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I7827_RS11850	COG1796	DNA polymerase
I7827_RS11860	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
I7827_RS11865	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I7827_RS11870	COG0072	phenylalanine-tRNA ligase activity
I7827_RS11870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I7827_RS11875	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I7827_RS11880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I7827_RS11900	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I7827_RS11905	COG0742	ribosomal rna small subunit methyltransferase
I7827_RS11920	COG0584	glycerophosphoryl diester phosphodiesterase
I7827_RS11925	COG3679	Belongs to the UPF0342 family
I7827_RS11930	COG2340	Cysteine-rich secretory protein family
I7827_RS11950	COG3336	cytochrome c oxidase
I7827_RS11975	COG0109	protoheme IX farnesyltransferase activity
I7827_RS11980	COG1612	heme a metabolic process
I7827_RS11990	COG0772	Belongs to the SEDS family
I7827_RS11995	COG4838	Belongs to the UPF0358 family
I7827_RS12005	COG4896	Protein conserved in bacteria
I7827_RS12015	COG1217	gtp-binding protein TYPA
I7827_RS12025	COG0483	inositol monophosphate 1-phosphatase activity
I7827_RS12045	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I7827_RS12050	COG1177	transmembrane transport
I7827_RS12055	COG1176	ABC-type spermidine putrescine transport system, permease component I
I7827_RS12060	COG3842	ATPase activity
I7827_RS12070	COG4476	Belongs to the UPF0223 family
I7827_RS12090	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I7827_RS12100	COG0242	peptide deformylase activity
I7827_RS12115	COG0561	phosphatase activity
I7827_RS12120	COG5503	Protein of unknown function (DUF1447)
I7827_RS12130	COG0569	domain protein
I7827_RS12140	COG1271	oxidase subunit
I7827_RS12150	COG1408	metallophosphoesterase
I7827_RS12170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I7827_RS12180	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I7827_RS12195	COG4172	Belongs to the ABC transporter superfamily
I7827_RS12205	COG0151	Belongs to the GarS family
I7827_RS12210	COG0138	bifunctional purine biosynthesis protein purh
I7827_RS12220	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I7827_RS12240	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I7827_RS12245	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I7827_RS12255	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I7827_RS12290	COG3964	amidohydrolase
I7827_RS12295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I7827_RS12295	COG1017	nitric oxide dioxygenase activity
I7827_RS12300	COG1959	2 iron, 2 sulfur cluster binding
I7827_RS12310	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I7827_RS12315	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I7827_RS12320	COG1845	cytochrome c oxidase, subunit III
I7827_RS12325	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I7827_RS12330	COG0813	purine-nucleoside phosphorylase activity
I7827_RS12350	COG1134	teichoic acid transport
I7827_RS12360	COG1682	transport, permease protein
I7827_RS12380	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I7827_RS12395	COG0463	Glycosyl transferase, family 2
I7827_RS12395	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I7827_RS12405	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I7827_RS12410	COG0463	Glycosyl transferase, family 2
I7827_RS12410	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I7827_RS12415	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I7827_RS12435	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I7827_RS12440	COG1682	transport, permease protein
I7827_RS12465	COG0183	Belongs to the thiolase family
I7827_RS12470	COG0318	PFAM AMP-dependent synthetase and ligase
I7827_RS12475	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I7827_RS12480	COG1316	TRANSCRIPTIONal
I7827_RS12490	COG2153	protein acetylation
I7827_RS12500	COG3594	Acyltransferase
I7827_RS12510	COG0436	Aminotransferase
I7827_RS12515	COG4187	Peptidase family M20/M25/M40
I7827_RS12520	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I7827_RS12525	COG0596	Alpha beta hydrolase
I7827_RS12535	COG1169	isochorismate synthase
I7827_RS12540	COG1575	Belongs to the MenA family. Type 1 subfamily
I7827_RS12610	COG4873	Protein conserved in bacteria
I7827_RS12620	COG0737	Belongs to the 5'-nucleotidase family
I7827_RS12625	COG3852	Histidine kinase
I7827_RS12630	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I7827_RS12635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I7827_RS12635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I7827_RS12640	COG0861	Integral membrane protein TerC family
I7827_RS12645	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I7827_RS12655	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I7827_RS12660	COG1131	(ABC) transporter
I7827_RS12675	COG2814	Major facilitator Superfamily
I7827_RS12680	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I7827_RS12685	COG2382	esterase
I7827_RS12690	COG1115	amino acid carrier protein
I7827_RS12695	COG0628	permease
I7827_RS12705	COG0569	domain protein
I7827_RS12705	COG0475	glutathione-regulated potassium exporter activity
I7827_RS12710	COG2239	Acts as a magnesium transporter
I7827_RS12715	COG0564	pseudouridine synthase activity
I7827_RS12725	COG2357	RelA SpoT domain protein
I7827_RS12735	COG4116	CYTH
I7827_RS12740	COG2346	COG2346, Truncated hemoglobins
I7827_RS12745	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I7827_RS12750	COG1164	Oligoendopeptidase f
I7827_RS12760	COG4862	establishment of competence for transformation
I7827_RS12765	COG1393	Belongs to the ArsC family
I7827_RS12775	COG4166	transmembrane transport
I7827_RS12780	COG4166	transmembrane transport
I7827_RS12785	COG4166	transmembrane transport
I7827_RS12790	COG4166	transmembrane transport
I7827_RS12795	COG4608	Belongs to the ABC transporter superfamily
I7827_RS12800	COG0444	Belongs to the ABC transporter superfamily
I7827_RS12805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I7827_RS12810	COG0601	transmembrane transport
I7827_RS12835	COG0542	response to heat
I7827_RS12840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I7827_RS12845	COG2151	metal-sulfur cluster biosynthetic enzyme
I7827_RS12850	COG0561	phosphatase activity
I7827_RS12855	COG1307	EDD domain protein, DegV family
I7827_RS12865	COG1874	Beta-galactosidase
I7827_RS12865	COG0366	Alpha amylase catalytic
I7827_RS12875	COG0179	Fumarylacetoacetate (FAA) hydrolase
I7827_RS12880	COG2311	Membrane
I7827_RS12890	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I7827_RS12905	COG0398	Pfam SNARE associated Golgi protein
I7827_RS12920	COG0137	argininosuccinate synthase activity
I7827_RS12925	COG0165	Argininosuccinate lyase
I7827_RS12935	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I7827_RS12940	COG1012	belongs to the aldehyde dehydrogenase family
I7827_RS12945	COG1098	S1 RNA binding domain
I7827_RS12955	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I7827_RS12965	COG2111	Na H antiporter
I7827_RS12965	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I7827_RS12970	COG2111	Na H antiporter
I7827_RS12985	COG1863	multisubunit Na H antiporter MnhE subunit
I7827_RS12990	COG2212	antiporter activity
I7827_RS12995	COG1320	monovalent cation:proton antiporter activity
I7827_RS13000	COG1028	Short-chain dehydrogenase reductase Sdr
I7827_RS13005	COG2050	protein possibly involved in aromatic compounds catabolism
I7827_RS13010	COG2056	Na+-H+ antiporter family
I7827_RS13015	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I7827_RS13025	COG1252	NADH dehydrogenase
I7827_RS13030	COG0316	Belongs to the HesB IscA family
I7827_RS13035	COG4844	belongs to the
I7827_RS13040	COG1252	NADH dehydrogenase
I7827_RS13045	COG4837	Protein of unknown function (DUF1462)
I7827_RS13050	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I7827_RS13055	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I7827_RS13060	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I7827_RS13065	COG1696	Membrane protein involved in D-alanine export
I7827_RS13080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I7827_RS13085	COG0647	UMP catabolic process
I7827_RS13090	COG2445	Protein of unknown function DUF86
I7827_RS13100	COG4470	Protein conserved in bacteria
I7827_RS13105	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I7827_RS13110	COG0737	Belongs to the 5'-nucleotidase family
I7827_RS13115	COG0730	response to heat
I7827_RS13120	COG1801	Protein of unknown function DUF72
I7827_RS13125	COG1136	(ABC) transporter
I7827_RS13145	COG1388	LysM domain
I7827_RS13145	COG0860	N-Acetylmuramoyl-L-alanine amidase
I7827_RS13155	COG1395	domain, Protein
I7827_RS13170	COG0800	Aldolase
I7827_RS13175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I7827_RS13180	COG1028	Short-chain dehydrogenase reductase Sdr
I7827_RS13185	COG1940	carbohydrate kinase activity
I7827_RS13190	COG2814	Major facilitator Superfamily
I7827_RS13200	COG0719	Fe-S assembly protein
I7827_RS13205	COG0822	iron-sulfur transferase activity
I7827_RS13210	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I7827_RS13215	COG0719	Fe-S assembly protein
I7827_RS13220	COG0396	ATPase activity
I7827_RS13235	COG1464	Belongs to the NlpA lipoprotein family
I7827_RS13240	COG2011	ABC-type metal ion transport system permease component
I7827_RS13245	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I7827_RS13255	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I7827_RS13260	COG0509	glycine decarboxylation via glycine cleavage system
I7827_RS13265	COG1393	Belongs to the ArsC family
I7827_RS13270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I7827_RS13280	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
I7827_RS13280	COG0778	Nitroreductase
I7827_RS13285	COG0710	3-dehydroquinate dehydratase activity
I7827_RS13305	COG0697	spore germination
I7827_RS13310	COG1764	response to oxidative stress
I7827_RS13335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I7827_RS13350	COG4166	transmembrane transport
I7827_RS13365	COG0523	cobalamin synthesis protein
I7827_RS13370	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I7827_RS13420	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I7827_RS13435	COG0477	Major facilitator Superfamily
I7827_RS13450	COG0406	alpha-ribazole phosphatase activity
I7827_RS13460	COG1525	nuclease
I7827_RS13475	COG1280	lysine exporter protein (LysE YggA)
I7827_RS13500	COG0456	acetyltransferase
I7827_RS13500	COG1846	Transcriptional regulator
I7827_RS13510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I7827_RS13515	COG0730	response to heat
I7827_RS13580	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I7827_RS13585	COG0557	exoribonuclease II activity
I7827_RS13590	COG1647	Serine aminopeptidase, S33
I7827_RS13595	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I7827_RS13600	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I7827_RS13605	COG0148	phosphopyruvate hydratase activity
I7827_RS13615	COG0149	triose-phosphate isomerase activity
I7827_RS13620	COG0126	phosphoglycerate kinase activity
I7827_RS13640	COG0740	serine-type endopeptidase activity
I7827_RS13645	COG1481	regulation of sporulation
I7827_RS13655	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I7827_RS13660	COG1660	Displays ATPase and GTPase activities
I7827_RS13675	COG0110	maltose O-acetyltransferase activity
I7827_RS13680	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I7827_RS13685	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I7827_RS13715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I7827_RS13720	COG3942	CHAP domain
I7827_RS13725	COG2010	Cytochrome c
I7827_RS13735	COG0653	protein targeting
I7827_RS13740	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I7827_RS13745	COG1040	competence protein
I7827_RS13750	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I7827_RS13755	COG1307	EDD domain protein, DegV family
I7827_RS13765	COG1739	Uncharacterized protein family UPF0029
I7827_RS13770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I7827_RS13775	COG2199	diguanylate cyclase activity
I7827_RS13810	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I7827_RS13820	COG0456	acetyltransferase
I7827_RS13935	COG2249	NAD(P)H dehydrogenase (quinone) activity
I7827_RS13940	COG0477	Major facilitator Superfamily
I7827_RS13965	COG1192	Involved in chromosome partitioning
I7827_RS14075	COG2003	Belongs to the UPF0758 family