locus-tag	class	description
CO689_RS00180	COG2814	Major facilitator Superfamily
CO689_RS00195	COG2124	cytochrome p450
CO689_RS00240	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CO689_RS00245	COG3775	system Galactitol-specific IIC component
CO689_RS00250	COG1609	Transcriptional regulator
CO689_RS00255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CO689_RS00270	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CO689_RS00370	COG2807	transmembrane transport
CO689_RS00410	COG2113	Glycine betaine
CO689_RS00415	COG2409	Drug exporters of the RND superfamily
CO689_RS00460	COG1620	l-lactate permease
CO689_RS00465	COG0579	oxidoreductase
CO689_RS00480	COG1302	Protein conserved in bacteria
CO689_RS00510	COG3237	CsbD-like
CO689_RS00515	COG0366	Alpha amylase catalytic
CO689_RS00530	COG2801	Transposase and inactivated derivatives
CO689_RS00580	COG3682	Transcriptional regulator
CO689_RS00590	COG0659	secondary active sulfate transmembrane transporter activity
CO689_RS00605	COG1733	regulation of RNA biosynthetic process
CO689_RS00610	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CO689_RS00615	COG0693	protein deglycase activity
CO689_RS00620	COG1686	Belongs to the peptidase S11 family
CO689_RS00695	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
CO689_RS00695	COG4932	domain protein
CO689_RS00695	COG3266	domain, Protein
CO689_RS00830	COG0589	response to stress
CO689_RS00845	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CO689_RS00850	COG0827	DNA restriction-modification system
CO689_RS00855	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CO689_RS00860	COG0730	response to heat
CO689_RS00865	COG0301	tRNA thio-modification
CO689_RS00870	COG1104	cysteine desulfurase activity
CO689_RS00875	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
CO689_RS00880	COG1956	GAF domain-containing protein
CO689_RS00890	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CO689_RS00900	COG0584	glycerophosphoryl diester phosphodiesterase
CO689_RS00905	COG1764	response to oxidative stress
CO689_RS00910	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CO689_RS00915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CO689_RS00925	COG1263	PTS System
CO689_RS00925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO689_RS00930	COG0204	Acyl-transferase
CO689_RS00935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CO689_RS00940	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CO689_RS00950	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CO689_RS00955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CO689_RS00960	COG0454	-acetyltransferase
CO689_RS00970	COG1609	Transcriptional regulator
CO689_RS00975	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CO689_RS00975	COG1605	Chorismate mutase
CO689_RS00985	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
CO689_RS00990	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CO689_RS00995	COG1674	ftsk spoiiie
CO689_RS01000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO689_RS01005	COG4848	Belongs to the UPF0354 family
CO689_RS01010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CO689_RS01015	COG1363	Peptidase, m42
CO689_RS01025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CO689_RS01030	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CO689_RS01035	COG0510	thiamine kinase activity
CO689_RS01045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CO689_RS01055	COG1187	pseudouridine synthase activity
CO689_RS01060	COG2244	polysaccharide biosynthetic process
CO689_RS01065	COG2081	HI0933 family
CO689_RS01070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CO689_RS01080	COG2814	Major facilitator Superfamily
CO689_RS01085	COG1242	4 iron, 4 sulfur cluster binding
CO689_RS01090	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
CO689_RS01095	COG0039	L-malate dehydrogenase activity
CO689_RS01100	COG2267	carboxylic ester hydrolase activity
CO689_RS01110	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CO689_RS01120	COG0307	riboflavin synthase, alpha
CO689_RS01125	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CO689_RS01125	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CO689_RS01135	COG5632	N-Acetylmuramoyl-L-alanine amidase
CO689_RS01135	COG4193	domain, Protein
CO689_RS01135	COG3266	domain, Protein
CO689_RS01145	COG1595	DNA-templated transcription, initiation
CO689_RS01160	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CO689_RS01175	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CO689_RS01180	COG0656	L-ascorbic acid biosynthetic process
CO689_RS01190	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CO689_RS01195	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CO689_RS01200	COG1506	peptidase
CO689_RS01205	COG0494	nUDIX hydrolase
CO689_RS01210	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CO689_RS01220	COG0318	PFAM AMP-dependent synthetase and ligase
CO689_RS01285	COG1827	regulation of RNA biosynthetic process
CO689_RS01295	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CO689_RS01300	COG0157	Belongs to the NadC ModD family
CO689_RS01305	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CO689_RS01315	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CO689_RS01320	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CO689_RS01325	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CO689_RS01340	COG1131	(ABC) transporter
CO689_RS01345	COG0537	adenosine 5'-monophosphoramidase activity
CO689_RS01360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CO689_RS01365	COG3481	metal-dependent phosphohydrolase, HD sub domain
CO689_RS01375	COG0420	3'-5' exonuclease activity
CO689_RS01385	COG4399	Belongs to the UPF0754 family
CO689_RS01400	COG2197	response regulator
CO689_RS01405	COG2203	Gaf domain
CO689_RS01405	COG4585	Histidine kinase
CO689_RS01410	COG0564	pseudouridine synthase activity
CO689_RS01415	COG0114	fumarate hydratase activity
CO689_RS01425	COG0363	glucosamine-6-phosphate deaminase activity
CO689_RS01435	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CO689_RS01440	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CO689_RS01445	COG1126	abc transporter atp-binding protein
CO689_RS01450	COG0765	amino acid transport
CO689_RS01605	COG0735	belongs to the Fur family
CO689_RS01610	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CO689_RS01615	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CO689_RS01620	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CO689_RS01625	COG4129	membrane
CO689_RS01635	COG3557	Belongs to the UPF0374 family
CO689_RS01640	COG1194	a g-specific adenine glycosylase
CO689_RS01645	COG1988	membrane-bound metal-dependent
CO689_RS01655	COG1134	teichoic acid transport
CO689_RS01655	COG1388	LysM domain
CO689_RS01665	COG2137	regulation of response to DNA damage stimulus
CO689_RS01670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CO689_RS01675	COG0693	protein deglycase activity
CO689_RS01685	COG0535	radical SAM domain protein
CO689_RS01690	COG1607	acyl-coa hydrolase
CO689_RS01695	COG2309	aminopeptidase activity
CO689_RS01700	COG4840	Belongs to the UPF0435 family
CO689_RS01715	COG1295	ribonuclease BN
CO689_RS01720	COG0288	reversible hydration of carbon dioxide
CO689_RS01725	COG2197	response regulator
CO689_RS01745	COG0024	Methionine aminopeptidase
CO689_RS01750	COG4129	membrane
CO689_RS01770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CO689_RS01775	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CO689_RS01780	COG1597	lipid kinase activity
CO689_RS01785	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CO689_RS01790	COG0154	amidase activity
CO689_RS01795	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CO689_RS01800	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CO689_RS01810	COG4851	CamS sex pheromone cAM373 precursor
CO689_RS01815	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CO689_RS01825	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CO689_RS01830	COG4496	protein, YerC YecD
CO689_RS01835	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CO689_RS01845	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
CO689_RS01850	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CO689_RS01855	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CO689_RS01865	COG0077	Prephenate dehydratase
CO689_RS01870	COG1012	belongs to the aldehyde dehydrogenase family
CO689_RS01875	COG1227	inorganic diphosphatase activity
CO689_RS01880	COG1335	isochorismatase
CO689_RS01890	COG0471	metal ion transport
CO689_RS01895	COG2706	6-phosphogluconolactonase activity
CO689_RS01920	COG1136	(ABC) transporter
CO689_RS01950	COG1131	(ABC) transporter
CO689_RS01965	COG1725	Transcriptional regulator
CO689_RS02075	COG1396	sequence-specific DNA binding
CO689_RS02075	COG3800	Transcriptional regulator
CO689_RS02080	COG0582	viral genome integration into host DNA
CO689_RS02085	COG0459	protein refolding
CO689_RS02090	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CO689_RS02110	COG4512	PFAM Accessory gene regulator B
CO689_RS02130	COG1621	beta-fructofuranosidase activity
CO689_RS02135	COG2391	methyltransferase activity
CO689_RS02140	COG0425	Belongs to the sulfur carrier protein TusA family
CO689_RS02145	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CO689_RS02150	COG0488	(ABC) transporter
CO689_RS02160	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CO689_RS02165	COG0456	acetyltransferase
CO689_RS02170	COG1214	PFAM Peptidase M22, glycoprotease
CO689_RS02175	COG0802	atpase or kinase
CO689_RS02180	COG0129	dihydroxy-acid dehydratase activity
CO689_RS02185	COG0028	Belongs to the TPP enzyme family
CO689_RS02195	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CO689_RS02200	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CO689_RS02205	COG0473	3-isopropylmalate dehydrogenase activity
CO689_RS02210	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CO689_RS02220	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CO689_RS02245	COG3091	SprT-like family
CO689_RS02250	COG2183	response to ionizing radiation
CO689_RS02255	COG1191	sigma factor activity
CO689_RS02270	COG2208	phosphoserine phosphatase activity
CO689_RS02285	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CO689_RS02290	COG0736	holo-[acyl-carrier-protein] synthase activity
CO689_RS02295	COG3402	PFAM membrane-flanked domain
CO689_RS02310	COG0513	Belongs to the DEAD box helicase family
CO689_RS02315	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CO689_RS02320	COG1181	Belongs to the D-alanine--D-alanine ligase family
CO689_RS02325	COG0772	Belongs to the SEDS family
CO689_RS02340	COG2217	Heavy metal translocating P-type atpase
CO689_RS02355	COG1937	Protein conserved in bacteria
CO689_RS02360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CO689_RS02365	COG1418	mRNA catabolic process
CO689_RS02370	COG0456	acetyltransferase
CO689_RS02375	COG0706	membrane insertase activity
CO689_RS02380	COG0352	thiamine-phosphate diphosphorylase activity
CO689_RS02385	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CO689_RS02395	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CO689_RS02405	COG1388	LysM domain
CO689_RS02410	COG0629	single-stranded DNA binding
CO689_RS02420	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CO689_RS02430	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CO689_RS02440	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CO689_RS02445	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CO689_RS02450	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CO689_RS02455	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CO689_RS02460	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CO689_RS02465	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CO689_RS02470	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CO689_RS02475	COG0356	it plays a direct role in the translocation of protons across the membrane
CO689_RS02485	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CO689_RS02490	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CO689_RS02495	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CO689_RS02500	COG4475	Protein of unknown function (DUF436)
CO689_RS02505	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CO689_RS02510	COG0009	L-threonylcarbamoyladenylate synthase
CO689_RS02515	COG2890	protein-(glutamine-N5) methyltransferase activity
CO689_RS02520	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CO689_RS02525	COG1435	thymidine kinase activity
CO689_RS02530	COG0254	rRNA binding
CO689_RS02535	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CO689_RS02540	COG1012	belongs to the aldehyde dehydrogenase family
CO689_RS02545	COG1733	regulation of RNA biosynthetic process
CO689_RS02550	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CO689_RS02555	COG0191	fructose-bisphosphate aldolase activity
CO689_RS02565	COG0504	CTP synthase activity
CO689_RS02570	COG3343	RNA polymerase activity
CO689_RS02575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CO689_RS02600	COG1854	S-ribosylhomocysteine lyase activity
CO689_RS02610	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CO689_RS02615	COG0813	purine-nucleoside phosphorylase activity
CO689_RS02620	COG1876	peptidase activity
CO689_RS02625	COG0783	Belongs to the Dps family
CO689_RS02650	COG1556	Lactate utilization protein
CO689_RS02655	COG1139	Iron-sulfur cluster binding protein
CO689_RS02660	COG0247	lactate metabolic process
CO689_RS02665	COG2186	Transcriptional regulator
CO689_RS02670	COG0702	epimerase
CO689_RS02675	COG0640	Transcriptional regulator
CO689_RS02695	COG0561	phosphatase activity
CO689_RS02700	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CO689_RS02710	COG3711	transcriptional antiterminator
CO689_RS02715	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO689_RS02720	COG0246	Mannitol dehydrogenase
CO689_RS02725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CO689_RS02730	COG4856	YbbR-like protein
CO689_RS02735	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CO689_RS02785	COG0489	protein tyrosine kinase activity
CO689_RS02790	COG2814	Major facilitator Superfamily
CO689_RS02805	COG1272	protein, Hemolysin III
CO689_RS02810	COG4284	Utp--glucose-1-phosphate uridylyltransferase
CO689_RS02815	COG1988	membrane-bound metal-dependent
CO689_RS02830	COG2329	Antibiotic biosynthesis monooxygenase
CO689_RS02835	COG3314	Sporulation integral membrane protein YlbJ
CO689_RS02840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CO689_RS02845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CO689_RS02850	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CO689_RS02860	COG3457	Alanine racemase
CO689_RS02865	COG4264	IucA IucC family
CO689_RS02870	COG2814	Major facilitator Superfamily
CO689_RS02880	COG1302	Protein conserved in bacteria
CO689_RS02895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CO689_RS02900	COG0604	alcohol dehydrogenase
CO689_RS02905	COG0604	alcohol dehydrogenase
CO689_RS02910	COG2130	NADP-dependent
CO689_RS02920	COG2130	NADP-dependent
CO689_RS02925	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CO689_RS02930	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CO689_RS02930	COG0574	Belongs to the PEP-utilizing enzyme family
CO689_RS02935	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CO689_RS02945	COG2608	mercury ion transmembrane transporter activity
CO689_RS02950	COG2318	DinB family
CO689_RS02955	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO689_RS02955	COG2213	PTS system mannitol-specific
CO689_RS02980	COG1442	glycosyl transferase family 8
CO689_RS02985	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CO689_RS02990	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CO689_RS02995	COG0101	tRNA pseudouridine synthase activity
CO689_RS03015	COG0203	ribosomal protein L17
CO689_RS03020	COG0202	RNA polymerase activity
CO689_RS03025	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CO689_RS03030	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CO689_RS03035	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CO689_RS03045	COG0563	adenylate kinase activity
CO689_RS03050	COG0201	protein transport
CO689_RS03055	COG0200	Binds to the 23S rRNA
CO689_RS03060	COG1841	ribosomal large subunit assembly
CO689_RS03065	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CO689_RS03070	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CO689_RS03075	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CO689_RS03080	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CO689_RS03085	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CO689_RS03090	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CO689_RS03095	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CO689_RS03100	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CO689_RS03105	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CO689_RS03115	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CO689_RS03120	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CO689_RS03125	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CO689_RS03130	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CO689_RS03135	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CO689_RS03140	COG0089	rRNA binding
CO689_RS03145	COG0088	Forms part of the polypeptide exit tunnel
CO689_RS03150	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CO689_RS03155	COG0051	transcription antitermination factor activity, RNA binding
CO689_RS03170	COG2252	PERMEase
CO689_RS03190	COG4975	Glucose uptake
CO689_RS03220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CO689_RS03225	COG2348	transferase activity, transferring amino-acyl groups
CO689_RS03245	COG2814	Major facilitator Superfamily
CO689_RS03250	COG2197	response regulator
CO689_RS03260	COG0842	Transport permease protein
CO689_RS03265	COG1131	(ABC) transporter
CO689_RS03275	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CO689_RS03280	COG0746	molybdenum cofactor guanylyltransferase activity
CO689_RS03290	COG0314	molybdopterin synthase activity
CO689_RS03300	COG0303	'Molybdopterin
CO689_RS03305	COG0315	cyclic pyranopterin monophosphate synthase activity
CO689_RS03310	COG0521	Mo-molybdopterin cofactor biosynthetic process
CO689_RS03315	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CO689_RS03320	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CO689_RS03325	COG4149	molybdate abc transporter
CO689_RS03330	COG0725	ABC transporter, periplasmic molybdate-binding protein
CO689_RS03335	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CO689_RS03340	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CO689_RS03345	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CO689_RS03350	COG1609	Transcriptional regulator
CO689_RS03355	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CO689_RS03365	COG1268	BioY protein
CO689_RS03370	COG1957	nucleoside hydrolase
CO689_RS03375	COG1960	acyl-CoA dehydrogenase activity
CO689_RS03380	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CO689_RS03390	COG0831	urea catabolic process
CO689_RS03395	COG0832	Belongs to the urease beta subunit family
CO689_RS03400	COG0804	urea catabolic process
CO689_RS03405	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CO689_RS03410	COG0830	nickel cation binding
CO689_RS03420	COG0829	nickel cation binding
CO689_RS03460	COG3942	CHAP domain
CO689_RS03470	COG1757	Na H antiporter
CO689_RS03485	COG2076	Multidrug Resistance protein
CO689_RS03490	COG2076	Multidrug Resistance protein
CO689_RS03495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CO689_RS03520	COG3383	formate dehydrogenase (NAD+) activity
CO689_RS03530	COG1316	TRANSCRIPTIONal
CO689_RS03555	COG1737	Transcriptional regulator
CO689_RS03560	COG1113	amino acid transport
CO689_RS03585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CO689_RS03595	COG2271	Major facilitator Superfamily
CO689_RS03610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CO689_RS03615	COG1028	Short-chain dehydrogenase reductase Sdr
CO689_RS03620	COG1473	amidohydrolase
CO689_RS03625	COG0659	secondary active sulfate transmembrane transporter activity
CO689_RS03630	COG1228	amidohydrolase
CO689_RS03635	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CO689_RS03640	COG3314	Sporulation integral membrane protein YlbJ
CO689_RS03645	COG0583	DNA-binding transcription factor activity
CO689_RS03650	COG0010	Belongs to the arginase family
CO689_RS03655	COG1266	CAAX protease self-immunity
CO689_RS03665	COG2017	converts alpha-aldose to the beta-anomer
CO689_RS03670	COG1742	UPF0060 membrane protein
CO689_RS03675	COG1668	transmembrane transport
CO689_RS03680	COG4152	abc transporter atp-binding protein
CO689_RS03710	COG2094	Belongs to the DNA glycosylase MPG family
CO689_RS03715	COG0602	queuosine metabolic process
CO689_RS03730	COG1304	FMN binding
CO689_RS03735	COG0598	Magnesium transport protein CorA
CO689_RS03755	COG1033	growth of symbiont in host cell
CO689_RS03755	COG2409	Drug exporters of the RND superfamily
CO689_RS03760	COG2814	Major facilitator Superfamily
CO689_RS03765	COG1566	PFAM secretion protein HlyD family protein
CO689_RS03775	COG2814	Major facilitator Superfamily
CO689_RS03800	COG0577	efflux transmembrane transporter activity
CO689_RS03805	COG0745	RESPONSE REGULATOR receiver
CO689_RS03810	COG3850	Histidine kinase
CO689_RS03810	COG5002	protein histidine kinase activity
CO689_RS03820	COG0438	transferase activity, transferring glycosyl groups
CO689_RS03825	COG1620	l-lactate permease
CO689_RS03830	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CO689_RS03840	COG0604	alcohol dehydrogenase
CO689_RS03845	COG2814	Major facilitator Superfamily
CO689_RS03870	COG1611	Belongs to the LOG family
CO689_RS03880	COG1301	dicarboxylic acid transport
CO689_RS03885	COG0697	spore germination
CO689_RS03895	COG0778	Nitroreductase
CO689_RS03900	COG1846	Transcriptional regulator
CO689_RS03920	COG3425	synthase
CO689_RS03925	COG0772	Belongs to the SEDS family
CO689_RS03930	COG2223	nitrite transmembrane transporter activity
CO689_RS03935	COG2197	response regulator
CO689_RS03940	COG4585	Histidine kinase
CO689_RS03950	COG2181	nitrate reductase activity
CO689_RS03960	COG1140	nitrate reductase beta subunit
CO689_RS03965	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CO689_RS03970	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CO689_RS03970	COG1648	precorrin-2 dehydrogenase activity
CO689_RS03980	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CO689_RS04035	COG1126	abc transporter atp-binding protein
CO689_RS04040	COG0765	amino acid transport
CO689_RS04045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CO689_RS04055	COG0588	phosphoglycerate mutase activity
CO689_RS04060	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CO689_RS04070	COG2814	Major facilitator Superfamily
CO689_RS04080	COG1113	amino acid transport
CO689_RS04090	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CO689_RS04100	COG3275	phosphorelay sensor kinase activity
CO689_RS04105	COG3279	Response regulator of the LytR AlgR family
CO689_RS04110	COG1380	Effector of murein hydrolase LrgA
CO689_RS04115	COG1346	cytolysis
CO689_RS04130	COG1309	transcriptional regulator
CO689_RS04140	COG1174	glycine betaine transport
CO689_RS04150	COG1174	glycine betaine transport
CO689_RS04160	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
CO689_RS04165	COG0531	amino acid
CO689_RS04170	COG2272	Belongs to the type-B carboxylesterase lipase family
CO689_RS04175	COG2814	Major facilitator Superfamily
CO689_RS04180	COG0390	transport system, permease component
CO689_RS04185	COG4619	ABC transporter
CO689_RS04210	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CO689_RS04215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CO689_RS04225	COG2610	gluconate transmembrane transporter activity
CO689_RS04235	COG1802	Transcriptional regulator
CO689_RS04250	COG0523	cobalamin synthesis protein
CO689_RS04255	COG4876	unkown
CO689_RS04260	COG1289	transmembrane transporter activity
CO689_RS04265	COG3527	Alpha-acetolactate decarboxylase
CO689_RS04275	COG2271	Major facilitator Superfamily
CO689_RS04280	COG0586	Pfam SNARE associated Golgi protein
CO689_RS04290	COG1129	ABC transporter
CO689_RS04295	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CO689_RS04300	COG3250	beta-galactosidase activity
CO689_RS04305	COG2207	Transcriptional regulator
CO689_RS04310	COG2211	Major facilitator Superfamily
CO689_RS04315	COG0346	lactoylglutathione lyase activity
CO689_RS04330	COG1132	(ABC) transporter
CO689_RS04335	COG1132	(ABC) transporter
CO689_RS04340	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CO689_RS04345	COG0778	Nitroreductase
CO689_RS04350	COG2249	NAD(P)H dehydrogenase (quinone) activity
CO689_RS04360	COG1760	l-serine dehydratase
CO689_RS04365	COG1760	l-serine dehydratase
CO689_RS04380	COG1609	Transcriptional regulator
CO689_RS04390	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CO689_RS04395	COG1687	branched-chain amino acid
CO689_RS04400	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CO689_RS04415	COG0028	Belongs to the TPP enzyme family
CO689_RS04425	COG1380	Effector of murein hydrolase LrgA
CO689_RS04430	COG1388	LysM domain
CO689_RS04435	COG0583	DNA-binding transcription factor activity
CO689_RS04440	COG0577	efflux transmembrane transporter activity
CO689_RS04445	COG1136	(ABC) transporter
CO689_RS04465	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CO689_RS04470	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
CO689_RS04470	COG3266	domain, Protein
CO689_RS04470	COG4932	domain protein
CO689_RS04475	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CO689_RS04480	COG3764	Sortase (surface protein transpeptidase)
CO689_RS04495	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CO689_RS04510	COG3001	Fructosamine kinase
CO689_RS04520	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CO689_RS04530	COG0604	alcohol dehydrogenase
CO689_RS04530	COG3321	synthase
CO689_RS04545	COG1882	Formate acetyltransferase
CO689_RS04550	COG3189	MarR family transcriptional regulator
CO689_RS04565	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CO689_RS04615	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CO689_RS04630	COG1070	Carbohydrate kinase
CO689_RS04635	COG1914	H( )-stimulated, divalent metal cation uptake system
CO689_RS04640	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CO689_RS04645	COG0439	Biotin carboxylase
CO689_RS04650	COG0511	ligase activity, forming carbon-carbon bonds
CO689_RS04655	COG1984	allophanate hydrolase subunit 2
CO689_RS04660	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CO689_RS04685	COG1518	maintenance of DNA repeat elements
CO689_RS04705	COG3250	beta-galactosidase activity
CO689_RS04710	COG1028	Short-chain dehydrogenase reductase Sdr
CO689_RS04715	COG1312	Catalyzes the dehydration of D-mannonate
CO689_RS04720	COG1904	glucuronate isomerase
CO689_RS04725	COG2211	Major facilitator Superfamily
CO689_RS04740	COG2207	Transcriptional regulator
CO689_RS04745	COG5646	InterPro IPR014922
CO689_RS04750	COG2807	transmembrane transport
CO689_RS04765	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CO689_RS04770	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CO689_RS04775	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CO689_RS04780	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CO689_RS04785	COG3257	ureidoglycine aminohydrolase activity
CO689_RS04800	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CO689_RS04805	COG1953	Uracil, thiamine, allantoin
CO689_RS04810	COG2508	Transcriptional regulator
CO689_RS04815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CO689_RS04830	COG1131	(ABC) transporter
CO689_RS04840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CO689_RS04855	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CO689_RS04875	COG0352	thiamine-phosphate diphosphorylase activity
CO689_RS04880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CO689_RS04890	COG2022	thiamine diphosphate biosynthetic process
CO689_RS04895	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CO689_RS04900	COG1438	arginine binding
CO689_RS04905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CO689_RS04915	COG2235	arginine
CO689_RS04925	COG0183	Belongs to the thiolase family
CO689_RS04930	COG0318	PFAM AMP-dependent synthetase and ligase
CO689_RS04950	COG1028	Short-chain dehydrogenase reductase Sdr
CO689_RS04970	COG1131	(ABC) transporter
CO689_RS04975	COG0446	pyridine nucleotide-disulphide oxidoreductase
CO689_RS04995	COG0463	Glycosyl transferase, family 2
CO689_RS05010	COG0531	amino acid
CO689_RS05025	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CO689_RS05045	COG1442	glycosyl transferase family 8
CO689_RS05045	COG1216	Glycosyl transferase, family 2
CO689_RS05050	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
CO689_RS05055	COG1461	Dihydroxyacetone kinase
CO689_RS05060	COG2376	Dihydroxyacetone kinase
CO689_RS05070	COG2824	Alkylphosphonate utilization operon protein PhnA
CO689_RS05080	COG1131	(ABC) transporter
CO689_RS05090	COG1113	amino acid transport
CO689_RS05100	COG1320	monovalent cation:proton antiporter activity
CO689_RS05105	COG2212	antiporter activity
CO689_RS05110	COG1863	multisubunit Na H antiporter MnhE subunit
CO689_RS05120	COG1006	Multisubunit Na H antiporter MnhC subunit
CO689_RS05125	COG2111	Na H antiporter
CO689_RS05130	COG2111	Na H antiporter
CO689_RS05130	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CO689_RS05135	COG0582	viral genome integration into host DNA
CO689_RS05165	COG1131	(ABC) transporter
CO689_RS05180	COG0640	Transcriptional regulator
CO689_RS05195	COG1737	Transcriptional regulator
CO689_RS05205	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CO689_RS05215	COG0640	Transcriptional regulator
CO689_RS05225	COG1454	alcohol dehydrogenase
CO689_RS05225	COG1012	belongs to the aldehyde dehydrogenase family
CO689_RS05255	COG2258	MOSC domain
CO689_RS05260	COG3588	fructose-bisphosphate aldolase
CO689_RS05280	COG0494	nUDIX hydrolase
CO689_RS05290	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CO689_RS05290	COG0463	Glycosyl transferase, family 2
CO689_RS05330	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CO689_RS05340	COG1181	Belongs to the D-alanine--D-alanine ligase family
CO689_RS05355	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CO689_RS05360	COG1012	belongs to the aldehyde dehydrogenase family
CO689_RS05365	COG1510	regulation of RNA biosynthetic process
CO689_RS05370	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CO689_RS05375	COG3961	Belongs to the TPP enzyme family
CO689_RS05385	COG2210	Belongs to the sulfur carrier protein TusA family
CO689_RS05425	COG1464	Belongs to the NlpA lipoprotein family
CO689_RS05430	COG2011	ABC-type metal ion transport system permease component
CO689_RS05435	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CO689_RS05450	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CO689_RS05455	COG0753	catalase activity
CO689_RS05465	COG0531	amino acid
CO689_RS05490	COG4336	lyase activity
CO689_RS05495	COG2814	Major facilitator Superfamily
CO689_RS05500	COG0069	glutamate synthase activity
CO689_RS05505	COG4221	oxidoreductase activity
CO689_RS05535	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CO689_RS05540	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CO689_RS05555	COG0706	membrane insertase activity
CO689_RS05615	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CO689_RS05620	COG0549	Belongs to the carbamate kinase family
CO689_RS05625	COG1288	antiporter activity
CO689_RS05645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CO689_RS05650	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CO689_RS05655	COG0022	dehydrogenase e1 component
CO689_RS05660	COG0508	dehydrogenase complex catalyzes the overall conversion of
CO689_RS05675	COG0556	nucleotide-excision repair
CO689_RS05680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CO689_RS05705	COG4932	domain protein
CO689_RS05705	COG4932	domain protein
CO689_RS05710	COG2207	Transcriptional regulator
CO689_RS05710	COG1609	Transcriptional regulator
CO689_RS05720	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CO689_RS05750	COG4195	phage-related replication protein
CO689_RS05765	COG1757	Na H antiporter
CO689_RS05775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CO689_RS05780	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CO689_RS05790	COG0579	oxidoreductase
CO689_RS05800	COG3321	synthase
CO689_RS05800	COG0604	alcohol dehydrogenase
CO689_RS05810	COG1511	domain protein
CO689_RS05825	COG1929	Belongs to the glycerate kinase type-1 family
CO689_RS05830	COG3871	stress protein (general stress protein 26)
CO689_RS05845	COG1288	antiporter activity
CO689_RS05855	COG1028	Short-chain dehydrogenase reductase Sdr
CO689_RS05860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CO689_RS05910	COG0667	Aldo Keto reductase
CO689_RS05915	COG0477	Major facilitator Superfamily
CO689_RS05925	COG0006	proline dipeptidase activity
CO689_RS05935	COG1664	Polymer-forming cytoskeletal
CO689_RS05940	COG0789	Transcriptional regulator
CO689_RS05950	COG0346	lactoylglutathione lyase activity
CO689_RS05955	COG2388	GCN5-related N-acetyl-transferase
CO689_RS05970	COG2388	GCN5-related N-acetyl-transferase
CO689_RS05975	COG1054	Belongs to the UPF0176 family
CO689_RS05985	COG1966	Carbon starvation protein
CO689_RS06005	COG3181	Tripartite tricarboxylate transporter family receptor
CO689_RS06040	COG1063	alcohol dehydrogenase
CO689_RS06045	COG1070	Carbohydrate kinase
CO689_RS06055	COG1609	Transcriptional regulator
CO689_RS06075	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CO689_RS06085	COG3716	PTS system mannose fructose sorbose family IID component
CO689_RS06090	COG3715	PTS system
CO689_RS06095	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO689_RS06095	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO689_RS06105	COG2222	sugar isomerase
CO689_RS06110	COG2188	Transcriptional regulator
CO689_RS06115	COG3586	endonuclease activity
CO689_RS06140	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO689_RS06145	COG3711	transcriptional antiterminator
CO689_RS06180	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CO689_RS06225	COG1053	succinate dehydrogenase
CO689_RS06225	COG0431	NADPH-dependent FMN reductase
CO689_RS06225	COG3976	FMN-binding domain protein
CO689_RS06245	COG0662	Cupin 2, conserved barrel domain protein
CO689_RS06250	COG0753	catalase activity
CO689_RS06260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CO689_RS06265	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CO689_RS06270	COG0531	amino acid
CO689_RS06275	COG1012	belongs to the aldehyde dehydrogenase family
CO689_RS06290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CO689_RS06295	COG2210	Belongs to the sulfur carrier protein TusA family
CO689_RS06300	COG1937	Protein conserved in bacteria
CO689_RS06305	COG0730	response to heat
CO689_RS06315	COG3246	L-lysine catabolic process to acetate
CO689_RS06320	COG1250	3-hydroxyacyl-CoA dehydrogenase
CO689_RS06345	COG2851	Citrate transporter
CO689_RS06365	COG1063	alcohol dehydrogenase
CO689_RS06380	COG0778	Nitroreductase
CO689_RS06405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CO689_RS06415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CO689_RS06430	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CO689_RS06435	COG0363	glucosamine-6-phosphate deaminase activity
CO689_RS06440	COG0598	Magnesium transport protein CorA
CO689_RS06450	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CO689_RS06480	COG1869	D-ribose catabolic process
CO689_RS06490	COG1609	Transcriptional regulator
CO689_RS06515	COG1686	Belongs to the peptidase S11 family
CO689_RS06520	COG0402	S-adenosylhomocysteine deaminase activity
CO689_RS06525	COG1482	cell wall glycoprotein biosynthetic process
CO689_RS06530	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CO689_RS06530	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO689_RS06530	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CO689_RS06535	COG3711	transcriptional antiterminator
CO689_RS06535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO689_RS06540	COG3477	response to acidic pH
CO689_RS06550	COG1064	alcohol dehydrogenase
CO689_RS06565	COG1705	Flagellar rod assembly protein muramidase FlgJ
CO689_RS06565	COG3942	CHAP domain
CO689_RS06610	COG1280	lysine exporter protein (LysE YggA)
CO689_RS06630	COG5002	protein histidine kinase activity
CO689_RS06635	COG0745	RESPONSE REGULATOR receiver
CO689_RS06645	COG1028	Short-chain dehydrogenase reductase Sdr
CO689_RS06700	COG0515	serine threonine protein kinase
CO689_RS06710	COG1388	LysM domain
CO689_RS06715	COG2217	Heavy metal translocating P-type atpase
CO689_RS06730	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CO689_RS06735	COG0640	Transcriptional regulator
CO689_RS06750	COG2130	NADP-dependent
CO689_RS06755	COG0702	epimerase
CO689_RS06765	COG0789	Transcriptional regulator
CO689_RS06780	COG2217	Heavy metal translocating P-type atpase
CO689_RS06790	COG0640	Transcriptional regulator
CO689_RS06855	COG1113	amino acid transport
CO689_RS06860	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CO689_RS06895	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CO689_RS06900	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CO689_RS06910	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CO689_RS06920	COG4863	YycH protein
CO689_RS06925	COG5002	protein histidine kinase activity
CO689_RS06930	COG0745	RESPONSE REGULATOR receiver
CO689_RS06945	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CO689_RS06955	COG0305	Participates in initiation and elongation during chromosome replication
CO689_RS06960	COG0359	binds to the 23S rRNA
CO689_RS06965	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CO689_RS06985	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CO689_RS06990	COG2986	histidine ammonia-lyase
CO689_RS06995	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CO689_RS07005	COG0187	DNA topoisomerase II activity
CO689_RS07010	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CO689_RS07020	COG0592	DNA-directed DNA polymerase activity
CO689_RS07025	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CO689_RS07035	COG0594	ribonuclease P activity
CO689_RS07040	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CO689_RS07050	COG0357	Ribosomal RNA small subunit methyltransferase G
CO689_RS07055	COG1475	DNA binding
CO689_RS07065	COG0436	Aminotransferase
CO689_RS07075	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CO689_RS07080	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CO689_RS07080	COG0646	methionine synthase
CO689_RS07085	COG0626	cystathionine gamma-synthase activity
CO689_RS07090	COG1475	DNA binding
CO689_RS07095	COG0668	transmembrane transport
CO689_RS07100	COG4481	Protein conserved in bacteria
CO689_RS07105	COG0012	GTP binding
CO689_RS07125	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CO689_RS07145	COG0360	Binds together with S18 to 16S ribosomal RNA
CO689_RS07155	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CO689_RS07170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CO689_RS07175	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CO689_RS07195	COG3634	alkyl hydroperoxide reductase activity
CO689_RS07200	COG0450	alkyl hydroperoxide reductase
CO689_RS07210	COG0778	Nitroreductase
CO689_RS07215	COG1823	symporter activity
CO689_RS07235	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CO689_RS07240	COG2233	PERMEase
CO689_RS07250	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CO689_RS07250	COG0519	Catalyzes the synthesis of GMP from XMP
CO689_RS07255	COG2514	catechol 2,3-dioxygenase activity
CO689_RS07270	COG1051	belongs to the nudix hydrolase family
CO689_RS07285	COG0175	sulfate reduction
CO689_RS07290	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CO689_RS07295	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CO689_RS07305	COG0730	response to heat
CO689_RS07310	COG2046	Belongs to the sulfate adenylyltransferase family
CO689_RS07315	COG0529	Catalyzes the synthesis of activated sulfate
CO689_RS07340	COG1683	Conserved Protein
CO689_RS07345	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CO689_RS07350	COG1695	Transcriptional regulator
CO689_RS07370	COG0346	lactoylglutathione lyase activity
CO689_RS07380	COG1279	arginine transmembrane transporter activity
CO689_RS07385	COG1755	Isoprenylcysteine carboxyl methyltransferase
CO689_RS07390	COG1647	Serine aminopeptidase, S33
CO689_RS07400	COG0733	neurotransmitter:sodium symporter activity
CO689_RS07405	COG1266	CAAX protease self-immunity
CO689_RS07410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CO689_RS07415	COG0626	cystathionine gamma-synthase activity
CO689_RS07425	COG2162	N-hydroxyarylamine O-acetyltransferase activity
CO689_RS07430	COG0737	Belongs to the 5'-nucleotidase family
CO689_RS07440	COG4841	protein insertion into membrane
CO689_RS07465	COG0583	DNA-binding transcription factor activity
CO689_RS07470	COG0067	glutamate synthase
CO689_RS07470	COG0069	glutamate synthase activity
CO689_RS07470	COG0070	glutamate synthase
CO689_RS07475	COG0493	'glutamate synthase
CO689_RS07485	COG0346	lactoylglutathione lyase activity
CO689_RS07490	COG1263	PTS System
CO689_RS07490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO689_RS07495	COG0366	Alpha amylase catalytic
CO689_RS07500	COG2188	Transcriptional regulator
CO689_RS07510	COG0583	DNA-binding transcription factor activity
CO689_RS07515	COG2814	Major facilitator Superfamily
CO689_RS07530	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CO689_RS07540	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CO689_RS07560	COG1982	Orn Lys Arg decarboxylase major
CO689_RS07565	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CO689_RS07570	COG3870	Protein conserved in bacteria
CO689_RS07575	COG0470	DNA polymerase III
CO689_RS07580	COG1774	PSP1 C-terminal conserved region
CO689_RS07590	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CO689_RS07595	COG2827	Endonuclease containing a URI domain
CO689_RS07600	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CO689_RS07630	COG1388	LysM domain
CO689_RS07630	COG3942	CHAP domain
CO689_RS07670	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO689_RS07670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO689_RS07675	COG0084	hydrolase, TatD family'
CO689_RS07680	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CO689_RS07685	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CO689_RS07690	COG4466	Protein conserved in bacteria
CO689_RS07700	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CO689_RS07705	COG0251	oxidation-reduction process
CO689_RS07710	COG2088	sporulation resulting in formation of a cellular spore
CO689_RS07715	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CO689_RS07720	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CO689_RS07725	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CO689_RS07730	COG0193	aminoacyl-tRNA hydrolase activity
CO689_RS07735	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CO689_RS07740	COG2244	polysaccharide biosynthetic process
CO689_RS07745	COG3956	TIGRFAM MazG family protein
CO689_RS07750	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CO689_RS07760	COG1098	S1 RNA binding domain
CO689_RS07775	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CO689_RS07780	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CO689_RS07800	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CO689_RS07805	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CO689_RS07810	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CO689_RS07900	COG2814	Major facilitator Superfamily
CO689_RS07910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CO689_RS07915	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CO689_RS07920	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CO689_RS07935	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CO689_RS07945	COG3880	PFAM UvrB UvrC protein
CO689_RS07950	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CO689_RS07955	COG0542	response to heat
CO689_RS07960	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CO689_RS07965	COG4956	integral membrane protein (PIN domain superfamily)
CO689_RS07975	COG1045	serine acetyltransferase
CO689_RS07980	COG0215	cysteine-tRNA ligase activity
CO689_RS07985	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CO689_RS07990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CO689_RS08005	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CO689_RS08015	COG0250	Participates in transcription elongation, termination and antitermination
CO689_RS08020	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CO689_RS08025	COG0081	regulation of translation
CO689_RS08030	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CO689_RS08035	COG0222	ribosome binding
CO689_RS08040	COG2813	Specifically methylates the guanine in position
CO689_RS08045	COG0085	RNA polymerase activity
CO689_RS08050	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CO689_RS08060	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CO689_RS08065	COG0049	tRNA binding
CO689_RS08070	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CO689_RS08075	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CO689_RS08080	COG1473	amidohydrolase
CO689_RS08100	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
CO689_RS08105	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
CO689_RS08120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CO689_RS08130	COG2832	Protein of unknown function (DUF454)
CO689_RS08135	COG0546	phosphoglycolate phosphatase activity
CO689_RS08145	COG0561	phosphatase activity
CO689_RS08150	COG1428	Deoxynucleoside kinase
CO689_RS08155	COG1428	Deoxynucleoside kinase
CO689_RS08165	COG0561	phosphatase activity
CO689_RS08170	COG0431	NADPH-dependent FMN reductase
CO689_RS08180	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CO689_RS08185	COG0363	glucosamine-6-phosphate deaminase activity
CO689_RS08190	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CO689_RS08195	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CO689_RS08200	COG1469	GTP cyclohydrolase I activity
CO689_RS08210	COG3639	organic phosphonate transmembrane transporter activity
CO689_RS08215	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CO689_RS08230	COG0737	Belongs to the 5'-nucleotidase family
CO689_RS08240	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CO689_RS08250	COG2363	Small membrane protein
CO689_RS08255	COG0531	amino acid
CO689_RS08260	COG0586	Pfam SNARE associated Golgi protein
CO689_RS08280	COG3253	May function as heme-dependent peroxidase
CO689_RS08285	COG0280	phosphate acetyltransferase
CO689_RS08290	COG0095	Lipoate-protein ligase
CO689_RS08310	COG4844	belongs to the
CO689_RS08320	COG0519	Catalyzes the synthesis of GMP from XMP
CO689_RS08325	COG1078	dGTPase activity
CO689_RS08335	COG1473	amidohydrolase
CO689_RS08345	COG0018	arginyl-trna synthetase
CO689_RS08350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CO689_RS08355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CO689_RS08360	COG0546	phosphoglycolate phosphatase activity
CO689_RS08405	COG0025	NhaP-type Na H and K H
CO689_RS08410	COG2348	transferase activity, transferring amino-acyl groups
CO689_RS08415	COG0803	Belongs to the bacterial solute-binding protein 9 family
CO689_RS08420	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CO689_RS08425	COG1121	(ABC) transporter
CO689_RS08435	COG0671	phosphoesterase, PA-phosphatase related
CO689_RS08440	COG1247	-acetyltransferase
CO689_RS08455	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CO689_RS08470	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CO689_RS08475	COG5609	conserved protein (DUF2294)
CO689_RS08480	COG1134	teichoic acid transport
CO689_RS08485	COG1682	transport, permease protein
CO689_RS08490	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CO689_RS08495	COG1216	Glycosyl transferase, family 2
CO689_RS08500	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CO689_RS08505	COG1686	Belongs to the peptidase S11 family
CO689_RS08510	COG1132	(ABC) transporter
CO689_RS08520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CO689_RS08525	COG1120	ATPase activity
CO689_RS08530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CO689_RS08535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CO689_RS08545	COG3949	Membrane
CO689_RS08565	COG2205	protein histidine kinase activity
CO689_RS08570	COG1136	(ABC) transporter
CO689_RS08575	COG0577	efflux transmembrane transporter activity
CO689_RS08580	COG1392	Phosphate transport regulator
CO689_RS08585	COG0306	phosphate transporter
CO689_RS08590	COG3942	CHAP domain
CO689_RS08590	COG1388	LysM domain
CO689_RS08600	COG2207	Transcriptional regulator
CO689_RS08610	COG0217	transcriptional regulatory protein
CO689_RS08690	COG0583	DNA-binding transcription factor activity
CO689_RS08730	COG1671	Belongs to the UPF0178 family
CO689_RS08740	COG1968	undecaprenyl-diphosphatase activity
CO689_RS08745	COG4988	ABC transporter
CO689_RS08750	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CO689_RS08760	COG0523	cobalamin synthesis protein
CO689_RS08765	COG4989	oxidoreductase activity
CO689_RS08775	COG0039	L-malate dehydrogenase activity
CO689_RS08780	COG0471	metal ion transport
CO689_RS08800	COG1464	Belongs to the NlpA lipoprotein family
CO689_RS08805	COG0039	L-malate dehydrogenase activity
CO689_RS08815	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CO689_RS08820	COG1349	DNA-binding transcription factor activity
CO689_RS08825	COG1105	Belongs to the carbohydrate kinase PfkB family
CO689_RS08830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CO689_RS08830	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CO689_RS08830	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CO689_RS08835	COG1253	flavin adenine dinucleotide binding
CO689_RS08860	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
CO689_RS08890	COG0720	synthase
CO689_RS08895	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CO689_RS08920	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CO689_RS08930	COG1368	sulfuric ester hydrolase activity
CO689_RS08935	COG0488	(ABC) transporter
CO689_RS08940	COG0514	ATP-dependent DNA helicase (RecQ)
CO689_RS08950	COG1174	glycine betaine transport
CO689_RS08955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CO689_RS08965	COG3104	oligopeptide transport
CO689_RS08970	COG3104	oligopeptide transport
CO689_RS08975	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CO689_RS08985	COG1780	Probably involved in ribonucleotide reductase function
CO689_RS08990	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CO689_RS08995	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CO689_RS09000	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CO689_RS09005	COG4605	iron ion homeostasis
CO689_RS09010	COG4604	ABC transporter, ATP-binding protein
CO689_RS09015	COG4607	ABC-type enterochelin transport system periplasmic component
CO689_RS09025	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CO689_RS09045	COG1929	Belongs to the glycerate kinase type-1 family
CO689_RS09050	COG2195	Cleaves the N-terminal amino acid of tripeptides
CO689_RS09070	COG2199	diguanylate cyclase activity
CO689_RS09075	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CO689_RS09080	COG1739	Uncharacterized protein family UPF0029
CO689_RS09090	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
CO689_RS09095	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CO689_RS09100	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CO689_RS09105	COG0653	protein targeting
CO689_RS09115	COG3942	CHAP domain
CO689_RS09135	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CO689_RS09140	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CO689_RS09145	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CO689_RS09150	COG0110	maltose O-acetyltransferase activity
CO689_RS09165	COG1660	Displays ATPase and GTPase activities
CO689_RS09170	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CO689_RS09175	COG1481	regulation of sporulation
CO689_RS09180	COG2814	Major facilitator Superfamily
CO689_RS09185	COG1114	Component of the transport system for branched-chain amino acids
CO689_RS09300	COG0740	serine-type endopeptidase activity
CO689_RS09330	COG0126	phosphoglycerate kinase activity
CO689_RS09340	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CO689_RS09345	COG0148	phosphopyruvate hydratase activity
CO689_RS09355	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CO689_RS09360	COG1647	Serine aminopeptidase, S33
CO689_RS09365	COG0557	exoribonuclease II activity
CO689_RS09370	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CO689_RS09385	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CO689_RS09390	COG0300	oxidoreductase activity
CO689_RS09395	COG1278	Cold shock
CO689_RS09405	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CO689_RS09410	COG1704	LemA family
CO689_RS09435	COG0710	3-dehydroquinate dehydratase activity
CO689_RS09445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CO689_RS09450	COG1393	Belongs to the ArsC family
CO689_RS09455	COG0509	glycine decarboxylation via glycine cleavage system
CO689_RS09460	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CO689_RS09465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CO689_RS09470	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CO689_RS09475	COG2011	ABC-type metal ion transport system permease component
CO689_RS09480	COG1464	Belongs to the NlpA lipoprotein family
CO689_RS09500	COG0396	ATPase activity
CO689_RS09505	COG0719	Fe-S assembly protein
CO689_RS09515	COG0822	iron-sulfur transferase activity
CO689_RS09525	COG4974	Belongs to the 'phage' integrase family
CO689_RS09560	COG3645	SOS response
CO689_RS09560	COG3646	Phage regulatory protein
CO689_RS09635	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CO689_RS09685	COG0756	dUTP diphosphatase activity
CO689_RS09740	COG4695	Portal protein
CO689_RS09795	COG0739	heme binding
CO689_RS09830	COG5632	N-Acetylmuramoyl-L-alanine amidase
CO689_RS09830	COG1388	LysM domain
CO689_RS09845	COG1253	flavin adenine dinucleotide binding
CO689_RS09855	COG1801	Protein of unknown function DUF72
CO689_RS09860	COG0730	response to heat
CO689_RS09865	COG0737	Belongs to the 5'-nucleotidase family
CO689_RS09870	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CO689_RS09875	COG4470	Protein conserved in bacteria
CO689_RS09885	COG2445	Protein of unknown function DUF86
CO689_RS09890	COG0647	UMP catabolic process
CO689_RS09895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CO689_RS09905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CO689_RS09910	COG1696	Membrane protein involved in D-alanine export
CO689_RS09915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CO689_RS09920	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
CO689_RS09925	COG0789	Transcriptional regulator
CO689_RS09930	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CO689_RS09935	COG4837	Protein of unknown function (DUF1462)
CO689_RS09940	COG1252	NADH dehydrogenase
CO689_RS09945	COG4844	belongs to the
CO689_RS09950	COG0316	Belongs to the HesB IscA family
CO689_RS09955	COG1252	NADH dehydrogenase
CO689_RS09960	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CO689_RS09965	COG2056	Na+-H+ antiporter family
CO689_RS09970	COG2050	protein possibly involved in aromatic compounds catabolism
CO689_RS09985	COG2212	antiporter activity
CO689_RS09990	COG1863	multisubunit Na H antiporter MnhE subunit
CO689_RS09995	COG0651	ATP synthesis coupled electron transport
CO689_RS10000	COG1006	Multisubunit Na H antiporter MnhC subunit
CO689_RS10005	COG2111	Na H antiporter
CO689_RS10010	COG2111	Na H antiporter
CO689_RS10010	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CO689_RS10020	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CO689_RS10045	COG1098	S1 RNA binding domain
CO689_RS10050	COG1902	pentaerythritol trinitrate reductase activity
CO689_RS10055	COG1012	belongs to the aldehyde dehydrogenase family
CO689_RS10060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CO689_RS10070	COG0165	Argininosuccinate lyase
CO689_RS10075	COG0137	argininosuccinate synthase activity
CO689_RS10080	COG0166	Belongs to the GPI family
CO689_RS10085	COG0398	Pfam SNARE associated Golgi protein
CO689_RS10100	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CO689_RS10105	COG1074	ATP-dependent DNA helicase activity
CO689_RS10125	COG0561	phosphatase activity
CO689_RS10150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CO689_RS10170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CO689_RS10175	COG0444	Belongs to the ABC transporter superfamily
CO689_RS10180	COG4608	Belongs to the ABC transporter superfamily
CO689_RS10185	COG4166	transmembrane transport
CO689_RS10190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CO689_RS10195	COG0454	-acetyltransferase
CO689_RS10210	COG0180	Tryptophanyl-tRNA synthetase
CO689_RS10215	COG1393	Belongs to the ArsC family
CO689_RS10220	COG4862	establishment of competence for transformation
CO689_RS10225	COG1164	Oligoendopeptidase f
CO689_RS10245	COG2346	COG2346, Truncated hemoglobins
CO689_RS10260	COG2357	RelA SpoT domain protein
CO689_RS10265	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CO689_RS10270	COG0564	pseudouridine synthase activity
CO689_RS10275	COG2239	Acts as a magnesium transporter
CO689_RS10280	COG0475	glutathione-regulated potassium exporter activity
CO689_RS10280	COG0569	domain protein
CO689_RS10290	COG2814	Major facilitator Superfamily
CO689_RS10295	COG0628	permease
CO689_RS10305	COG2382	esterase
CO689_RS10310	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CO689_RS10315	COG2814	Major facilitator Superfamily
CO689_RS10320	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CO689_RS10335	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CO689_RS10340	COG0861	Integral membrane protein TerC family
CO689_RS10345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CO689_RS10350	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CO689_RS10355	COG0140	phosphoribosyl-ATP diphosphatase activity
CO689_RS10355	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CO689_RS10360	COG0107	imidazoleglycerol-phosphate synthase activity
CO689_RS10365	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CO689_RS10370	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CO689_RS10375	COG0131	Imidazoleglycerol-phosphate dehydratase
CO689_RS10380	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CO689_RS10385	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CO689_RS10390	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CO689_RS10415	COG1129	ABC transporter
CO689_RS10450	COG1120	ATPase activity
CO689_RS10455	COG4509	Sortase family
CO689_RS10490	COG4873	Protein conserved in bacteria
CO689_RS10505	COG2314	TM2 domain
CO689_RS10515	COG1575	Belongs to the MenA family. Type 1 subfamily
CO689_RS10520	COG1169	isochorismate synthase
CO689_RS10525	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
CO689_RS10530	COG0596	Alpha beta hydrolase
CO689_RS10535	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CO689_RS10545	COG0436	Aminotransferase
CO689_RS10550	COG3594	Acyltransferase
CO689_RS10575	COG1316	TRANSCRIPTIONal
CO689_RS10585	COG1959	2 iron, 2 sulfur cluster binding
CO689_RS10590	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CO689_RS10610	COG1447	Phosphotransferase system cellobiose-specific component IIA
CO689_RS10615	COG2723	6-phospho-beta-galactosidase activity
CO689_RS10620	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CO689_RS10640	COG1105	Belongs to the carbohydrate kinase PfkB family
CO689_RS10645	COG0698	ribose 5-phosphate isomerase
CO689_RS10665	COG1349	DNA-binding transcription factor activity
CO689_RS10675	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CO689_RS10680	COG1845	cytochrome c oxidase, subunit III
CO689_RS10690	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CO689_RS10700	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CO689_RS10700	COG1017	nitric oxide dioxygenase activity
CO689_RS10705	COG1363	Peptidase, m42
CO689_RS10710	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CO689_RS10715	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CO689_RS10720	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CO689_RS10725	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CO689_RS10730	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CO689_RS10735	COG0047	phosphoribosylformylglycinamidine synthase activity
CO689_RS10740	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CO689_RS10745	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CO689_RS10750	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CO689_RS10760	COG0138	bifunctional purine biosynthesis protein purh
CO689_RS10765	COG0151	Belongs to the GarS family
CO689_RS10775	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CO689_RS10780	COG1122	ATPase activity
CO689_RS10795	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CO689_RS10810	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CO689_RS10820	COG1271	oxidase subunit
CO689_RS10825	COG1294	oxidase, subunit
CO689_RS10830	COG0569	domain protein
CO689_RS10840	COG5503	Protein of unknown function (DUF1447)
CO689_RS10850	COG0242	peptide deformylase activity
CO689_RS10880	COG4476	Belongs to the UPF0223 family
CO689_RS10895	COG1176	ABC-type spermidine putrescine transport system, permease component I
CO689_RS10900	COG1177	transmembrane transport
CO689_RS10920	COG1914	H( )-stimulated, divalent metal cation uptake system
CO689_RS10925	COG4493	Belongs to the UPF0637 family
CO689_RS10930	COG0483	inositol monophosphate 1-phosphatase activity
CO689_RS10940	COG1217	gtp-binding protein TYPA
CO689_RS10950	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CO689_RS10955	COG4838	Belongs to the UPF0358 family
CO689_RS10960	COG0772	Belongs to the SEDS family
CO689_RS10970	COG1612	heme a metabolic process
CO689_RS10975	COG0109	protoheme IX farnesyltransferase activity
CO689_RS10990	COG3679	Belongs to the UPF0342 family
CO689_RS10995	COG0584	glycerophosphoryl diester phosphodiesterase
CO689_RS11010	COG0742	ribosomal rna small subunit methyltransferase
CO689_RS11015	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CO689_RS11025	COG1323	Belongs to the UPF0348 family
CO689_RS11040	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CO689_RS11045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CO689_RS11050	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CO689_RS11055	COG0072	phenylalanine-tRNA ligase activity
CO689_RS11055	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CO689_RS11060	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CO689_RS11075	COG1796	DNA polymerase
CO689_RS11075	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CO689_RS11080	COG1193	negative regulation of DNA recombination
CO689_RS11085	COG3118	belongs to the thioredoxin family
CO689_RS11090	COG0322	excinuclease ABC activity
CO689_RS11095	COG2009	succinate dehydrogenase
CO689_RS11100	COG1053	succinate dehydrogenase
CO689_RS11105	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CO689_RS11115	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CO689_RS11130	COG0346	lactoylglutathione lyase activity
CO689_RS11145	COG2176	DNA-directed DNA polymerase activity
CO689_RS11185	COG1011	Hydrolase
CO689_RS11190	COG0454	-acetyltransferase
CO689_RS11195	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CO689_RS11200	COG2001	Belongs to the MraZ family
CO689_RS11205	COG0275	rRNA processing
CO689_RS11210	COG4839	cell division protein FtsL
CO689_RS11215	COG0768	penicillin binding
CO689_RS11220	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CO689_RS11225	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CO689_RS11235	COG0849	cell division
CO689_RS11250	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CO689_RS11255	COG1799	cell septum assembly
CO689_RS11260	COG0762	integral membrane protein
CO689_RS11270	COG3599	regulation of cell shape
CO689_RS11275	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CO689_RS11285	COG2514	catechol 2,3-dioxygenase activity
CO689_RS11295	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CO689_RS11300	COG0564	pseudouridine synthase activity
CO689_RS11310	COG1518	maintenance of DNA repeat elements
CO689_RS11325	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CO689_RS11335	COG0540	Belongs to the ATCase OTCase family
CO689_RS11345	COG0505	Belongs to the CarA family
CO689_RS11350	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CO689_RS11355	COG0543	2 iron, 2 sulfur cluster binding
CO689_RS11360	COG0167	dihydroorotate dehydrogenase activity
CO689_RS11365	COG0284	orotidine-5'-phosphate decarboxylase activity
CO689_RS11370	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CO689_RS11395	COG0194	GDP metabolic process
CO689_RS11400	COG1758	RNA polymerase activity
CO689_RS11410	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CO689_RS11415	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CO689_RS11420	COG2910	NAD(P)H-binding
CO689_RS11445	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CO689_RS11450	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CO689_RS11450	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CO689_RS11455	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CO689_RS11460	COG0631	protein serine/threonine phosphatase activity
CO689_RS11470	COG1162	GTPase activity
CO689_RS11475	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CO689_RS11480	COG1564	THIamine pyrophosphokinase
CO689_RS11490	COG1302	Protein conserved in bacteria
CO689_RS11495	COG1461	Dihydroxyacetone kinase
CO689_RS11500	COG1760	l-serine dehydratase
CO689_RS11505	COG1760	l-serine dehydratase
CO689_RS11515	COG1349	DNA-binding transcription factor activity
CO689_RS11520	COG0416	fatty acid biosynthetic process
CO689_RS11535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CO689_RS11540	COG0571	ribonuclease III activity
CO689_RS11545	COG1196	nuclear chromosome segregation
CO689_RS11550	COG0552	protein localization to endoplasmic reticulum
CO689_RS11555	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CO689_RS11560	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CO689_RS11565	COG0228	four-way junction DNA binding
CO689_RS11570	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CO689_RS11575	COG0336	Belongs to the RNA methyltransferase TrmD family
CO689_RS11580	COG0335	large ribosomal subunit rRNA binding
CO689_RS11595	COG4485	Bacterial membrane protein, YfhO
CO689_RS11600	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CO689_RS11625	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CO689_RS11630	COG0045	succinate-CoA ligase (ADP-forming) activity
CO689_RS11635	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CO689_RS11640	COG0758	DNA mediated transformation
CO689_RS11645	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CO689_RS11650	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CO689_RS11655	COG4974	Belongs to the 'phage' integrase family
CO689_RS11660	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CO689_RS11665	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CO689_RS11670	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CO689_RS11675	COG0052	Belongs to the universal ribosomal protein uS2 family
CO689_RS11685	COG0528	UMP kinase activity
CO689_RS11690	COG0233	cytoplasmic translational termination
CO689_RS11700	COG4589	Belongs to the CDS family
CO689_RS11710	COG0442	prolyl-tRNA aminoacylation
CO689_RS11720	COG0779	Required for maturation of 30S ribosomal subunits
CO689_RS11725	COG0195	Participates in both transcription termination and antitermination
CO689_RS11730	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CO689_RS11735	COG1358	cellular component organization or biogenesis
CO689_RS11740	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CO689_RS11750	COG0584	glycerophosphoryl diester phosphodiesterase
CO689_RS11760	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CO689_RS11765	COG1929	Belongs to the glycerate kinase type-1 family
CO689_RS11775	COG0745	RESPONSE REGULATOR receiver
CO689_RS11780	COG5002	protein histidine kinase activity
CO689_RS11780	COG3850	Histidine kinase
CO689_RS11790	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CO689_RS11795	COG0196	riboflavin kinase activity
CO689_RS11800	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CO689_RS11805	COG1185	polyribonucleotide nucleotidyltransferase activity
CO689_RS11810	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CO689_RS11820	COG2188	Transcriptional regulator
CO689_RS11825	COG0612	Peptidase, M16
CO689_RS11830	COG0612	Peptidase, M16
CO689_RS11835	COG0300	oxidoreductase activity
CO689_RS11855	COG1058	Belongs to the CinA family
CO689_RS11855	COG1546	Belongs to the CinA family
CO689_RS11860	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CO689_RS11865	COG1418	mRNA catabolic process
CO689_RS11875	COG0583	DNA-binding transcription factor activity
CO689_RS11885	COG1692	metallophosphoesterase
CO689_RS11890	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CO689_RS11890	COG0674	pyruvate-flavodoxin oxidoreductase activity
CO689_RS11895	COG1013	pyruvate-flavodoxin oxidoreductase activity
CO689_RS11910	COG0747	negative chemotaxis
CO689_RS11920	COG0444	Belongs to the ABC transporter superfamily
CO689_RS11925	COG4608	Belongs to the ABC transporter superfamily
CO689_RS11930	COG0601	transmembrane transport
CO689_RS11940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CO689_RS11945	COG4550	Control of competence regulator ComK, YlbF/YmcA
CO689_RS11955	COG0584	glycerophosphoryl diester phosphodiesterase
CO689_RS11960	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CO689_RS11965	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CO689_RS11975	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CO689_RS11980	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CO689_RS11985	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CO689_RS11995	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CO689_RS12000	COG1923	regulation of RNA biosynthetic process
CO689_RS12010	COG0386	Belongs to the glutathione peroxidase family
CO689_RS12015	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CO689_RS12020	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CO689_RS12045	COG0789	Transcriptional regulator
CO689_RS12050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CO689_RS12060	COG1525	nuclease
CO689_RS12085	COG0527	aspartate kinase activity
CO689_RS12090	COG0460	homoserine dehydrogenase
CO689_RS12095	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CO689_RS12100	COG0083	homoserine kinase activity
CO689_RS12115	COG0833	amino acid
CO689_RS12125	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CO689_RS12130	COG0516	GMP reductase activity
CO689_RS12135	COG2340	Cysteine-rich secretory protein family
CO689_RS12140	COG1609	Transcriptional regulator
CO689_RS12145	COG1621	beta-fructofuranosidase activity
CO689_RS12150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CO689_RS12160	COG2249	NAD(P)H dehydrogenase (quinone) activity
CO689_RS12170	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CO689_RS12180	COG4224	UPF0291 protein
CO689_RS12185	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CO689_RS12190	COG3763	UPF0154 protein
CO689_RS12195	COG4846	Membrane protein involved in cytochrome C biogenesis
CO689_RS12200	COG0420	3'-5' exonuclease activity
CO689_RS12210	COG1970	mechanosensitive ion channel activity
CO689_RS12215	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CO689_RS12220	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CO689_RS12230	COG4841	protein insertion into membrane
CO689_RS12245	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CO689_RS12250	COG1115	amino acid carrier protein
CO689_RS12255	COG3711	transcriptional antiterminator
CO689_RS12260	COG1263	PTS System
CO689_RS12260	COG2190	(PTS) system
CO689_RS12260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO689_RS12265	COG2190	(PTS) system
CO689_RS12265	COG1263	PTS System
CO689_RS12265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CO689_RS12270	COG0628	permease
CO689_RS12285	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CO689_RS12305	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CO689_RS12310	COG0287	Prephenate dehydrogenase
CO689_RS12315	COG1363	Peptidase, m42
CO689_RS12325	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CO689_RS12330	COG0512	Glutamine amidotransferase of anthranilate synthase
CO689_RS12335	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CO689_RS12340	COG0134	indole-3-glycerol-phosphate synthase activity
CO689_RS12345	COG0135	phosphoribosylanthranilate isomerase activity
CO689_RS12350	COG0133	tryptophan synthase activity
CO689_RS12355	COG0159	tryptophan synthase activity
CO689_RS12360	COG2348	transferase activity, transferring amino-acyl groups
CO689_RS12365	COG2348	transferase activity, transferring amino-acyl groups
CO689_RS12395	COG0747	negative chemotaxis
CO689_RS12405	COG1164	Oligoendopeptidase f
CO689_RS12410	COG0704	Plays a role in the regulation of phosphate uptake
CO689_RS12415	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CO689_RS12420	COG0581	inorganic phosphate transmembrane transporter activity
CO689_RS12425	COG0573	inorganic phosphate transmembrane transporter activity
CO689_RS12430	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CO689_RS12435	COG2996	Protein conserved in bacteria
CO689_RS12440	COG0488	(ABC) transporter
CO689_RS12450	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CO689_RS12455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CO689_RS12460	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CO689_RS12470	COG1473	amidohydrolase
CO689_RS12490	COG1278	Cold shock
CO689_RS12510	COG3853	Toxic anion resistance protein (TelA)
CO689_RS12515	COG1597	lipid kinase activity
CO689_RS12520	COG1114	Component of the transport system for branched-chain amino acids
CO689_RS12525	COG4548	von Willebrand factor, type A
CO689_RS12530	COG0714	Associated with various cellular activities
CO689_RS12555	COG0567	Dehydrogenase, E1 component
CO689_RS12560	COG5002	protein histidine kinase activity
CO689_RS12565	COG0745	RESPONSE REGULATOR receiver
CO689_RS12570	COG0671	phosphoesterase, PA-phosphatase related
CO689_RS12575	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CO689_RS12595	COG2190	(PTS) system
CO689_RS12600	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CO689_RS12630	COG1413	lyase activity
CO689_RS12640	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CO689_RS12645	COG0328	RNA-DNA hybrid ribonuclease activity
CO689_RS12650	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CO689_RS12655	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CO689_RS12660	COG2962	Rard protein
CO689_RS12665	COG0116	Belongs to the methyltransferase superfamily
CO689_RS12675	COG3599	regulation of cell shape
CO689_RS12680	COG4474	Belongs to the UPF0398 family
CO689_RS12690	COG3331	DNA recombination
CO689_RS12695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CO689_RS12695	COG4499	WXG100 protein secretion system (Wss), protein YukC
CO689_RS12705	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CO689_RS12710	COG3935	DnaD domain protein
CO689_RS12715	COG0017	Asparaginyl-tRNA synthetase
CO689_RS12720	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CO689_RS12720	COG1199	ATP-dependent helicase activity
CO689_RS12730	COG0617	tRNA 3'-terminal CCA addition
CO689_RS12735	COG0438	transferase activity, transferring glycosyl groups
CO689_RS12740	COG1694	Mazg nucleotide pyrophosphohydrolase
CO689_RS12745	COG2738	Putative neutral zinc metallopeptidase
CO689_RS12750	COG4347	Protein of unknown function (DUF1405)
CO689_RS12755	COG5582	Belongs to the UPF0302 family
CO689_RS12765	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CO689_RS12770	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CO689_RS12775	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CO689_RS12780	COG0105	UTP biosynthetic process
CO689_RS12785	COG0142	geranyltranstransferase activity
CO689_RS12790	COG2226	methyltransferase
CO689_RS12805	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CO689_RS12810	COG1160	GTP binding
CO689_RS12820	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CO689_RS12830	COG0492	ferredoxin-NADP+ reductase activity
CO689_RS12840	COG0514	ATP-dependent DNA helicase (RecQ)
CO689_RS12850	COG1141	Ferredoxin
CO689_RS12865	COG0745	RESPONSE REGULATOR receiver
CO689_RS12870	COG1187	pseudouridine synthase activity
CO689_RS12875	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CO689_RS12880	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CO689_RS12890	COG4974	Belongs to the 'phage' integrase family
CO689_RS12895	COG0735	belongs to the Fur family
CO689_RS12905	COG0667	Aldo Keto reductase
CO689_RS12915	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CO689_RS12920	COG1234	tRNA 3'-trailer cleavage
CO689_RS12925	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CO689_RS12940	COG2195	Cleaves the N-terminal amino acid of tripeptides
CO689_RS12945	COG4129	membrane
CO689_RS12955	COG0508	dehydrogenase complex catalyzes the overall conversion of
CO689_RS12960	COG0022	dehydrogenase e1 component
CO689_RS12965	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CO689_RS12970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CO689_RS12975	COG3426	butyrate kinase activity
CO689_RS12985	COG0280	phosphate acetyltransferase
CO689_RS12990	COG0497	DNA recombination
CO689_RS12995	COG1438	arginine binding
CO689_RS13005	COG1722	exodeoxyribonuclease VII activity
CO689_RS13010	COG1570	exodeoxyribonuclease VII activity
CO689_RS13015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CO689_RS13025	COG0439	Biotin carboxylase
CO689_RS13030	COG0511	ligase activity, forming carbon-carbon bonds
CO689_RS13035	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CO689_RS13040	COG0006	proline dipeptidase activity
CO689_RS13055	COG0095	Lipoate-protein ligase
CO689_RS13060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CO689_RS13065	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CO689_RS13070	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CO689_RS13075	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CO689_RS13105	COG1459	type II secretion system
CO689_RS13110	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CO689_RS13120	COG0011	TIGRFAM Protein of
CO689_RS13125	COG1940	carbohydrate kinase activity
CO689_RS13130	COG4483	Protein conserved in bacteria
CO689_RS13140	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CO689_RS13160	COG0768	penicillin binding
CO689_RS13170	COG0735	belongs to the Fur family
CO689_RS13175	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CO689_RS13180	COG1121	(ABC) transporter
CO689_RS13185	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CO689_RS13190	COG0513	Belongs to the DEAD box helicase family
CO689_RS13200	COG2384	SAM-dependent methyltransferase
CO689_RS13205	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CO689_RS13215	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CO689_RS13220	COG0517	IMP dehydrogenase activity
CO689_RS13225	COG0423	glycine-tRNA ligase activity
CO689_RS13230	COG1381	Involved in DNA repair and RecF pathway recombination
CO689_RS13235	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CO689_RS13245	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CO689_RS13250	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CO689_RS13255	COG1702	phosphate starvation-inducible protein PhoH
CO689_RS13265	COG4864	UPF0365 protein
CO689_RS13280	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CO689_RS13285	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CO689_RS13290	COG2264	protein methyltransferase activity
CO689_RS13295	COG0484	heat shock protein binding
CO689_RS13300	COG0443	Heat shock 70 kDa protein
CO689_RS13305	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CO689_RS13310	COG1420	regulation of RNA biosynthetic process
CO689_RS13315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CO689_RS13320	COG0481	GTPase activity
CO689_RS13325	COG0268	Binds directly to 16S ribosomal RNA
CO689_RS13330	COG1466	dna polymerase III delta subunit
CO689_RS13335	COG2333	competence protein COMEC
CO689_RS13335	COG0658	competence protein
CO689_RS13340	COG2131	deaminase
CO689_RS13345	COG1596	polysaccharide export
CO689_RS13345	COG1555	photosystem II stabilization
CO689_RS13355	COG0799	negative regulation of ribosome biogenesis
CO689_RS13360	COG1713	HD superfamily hydrolase involved in NAD metabolism
CO689_RS13370	COG1534	Rna-binding protein
CO689_RS13375	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CO689_RS13380	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CO689_RS13385	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CO689_RS13390	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CO689_RS13395	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CO689_RS13400	COG0572	uridine kinase
CO689_RS13405	COG0826	peptidase U32
CO689_RS13410	COG0826	peptidase U32
CO689_RS13415	COG4122	O-methyltransferase activity
CO689_RS13425	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CO689_RS13430	COG4472	Bacterial protein of unknown function (DUF965)
CO689_RS13435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CO689_RS13440	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CO689_RS13450	COG0482	sulfurtransferase activity
CO689_RS13455	COG1104	cysteine desulfurase activity
CO689_RS13460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CO689_RS13470	COG1959	2 iron, 2 sulfur cluster binding
CO689_RS13475	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CO689_RS13480	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CO689_RS13490	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CO689_RS13495	COG0124	histidyl-tRNA synthetase
CO689_RS13500	COG0860	N-Acetylmuramoyl-L-alanine amidase
CO689_RS13505	COG1490	D-aminoacyl-tRNA deacylase activity
CO689_RS13515	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CO689_RS13520	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CO689_RS13520	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CO689_RS13525	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CO689_RS13525	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CO689_RS13530	COG1862	Preprotein translocase
CO689_RS13535	COG0343	queuine tRNA-ribosyltransferase activity
CO689_RS13545	COG2255	four-way junction helicase activity
CO689_RS13550	COG0632	four-way junction helicase activity
CO689_RS13555	COG4492	Belongs to the UPF0735 family
CO689_RS13560	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CO689_RS13570	COG2868	ribosomal protein
CO689_RS13610	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CO689_RS13650	COG2003	Belongs to the UPF0758 family
CO689_RS13660	COG0285	dihydrofolate synthase activity
CO689_RS13665	COG0525	valine-tRNA ligase activity
CO689_RS13685	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CO689_RS13695	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CO689_RS13710	COG0181	hydroxymethylbilane synthase activity
CO689_RS13715	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CO689_RS13720	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CO689_RS13725	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CO689_RS13730	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CO689_RS13735	COG0544	peptidyl-prolyl cis-trans isomerase activity
CO689_RS13745	COG4112	unkown
CO689_RS13750	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CO689_RS13755	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CO689_RS13760	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CO689_RS13765	COG0833	amino acid
CO689_RS13770	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CO689_RS13775	COG1484	DNA-dependent DNA replication
CO689_RS13785	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CO689_RS13795	COG0237	dephospho-CoA kinase activity
CO689_RS13805	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CO689_RS13805	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CO689_RS13810	COG5002	protein histidine kinase activity
CO689_RS13815	COG0745	RESPONSE REGULATOR receiver
CO689_RS13820	COG0538	isocitrate dehydrogenase activity
CO689_RS13825	COG0372	Belongs to the citrate synthase family
CO689_RS13830	COG1113	amino acid transport
CO689_RS13835	COG0469	pyruvate kinase activity
CO689_RS13840	COG0205	6-phosphofructokinase activity
CO689_RS13845	COG0825	malonyl-CoA metabolic process
CO689_RS13850	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CO689_RS13855	COG0281	malic enzyme
CO689_RS13860	COG0587	DNA-directed DNA polymerase activity
CO689_RS13865	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CO689_RS13870	COG4109	DRTGG domain
CO689_RS13880	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CO689_RS13885	COG0006	proline dipeptidase activity