locus-tag	class	description
BI282_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BI282_RS00010	COG0592	DNA-directed DNA polymerase activity
BI282_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BI282_RS00025	COG0187	DNA topoisomerase II activity
BI282_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BI282_RS00040	COG2986	histidine ammonia-lyase
BI282_RS00045	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BI282_RS00065	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BI282_RS00070	COG0359	binds to the 23S rRNA
BI282_RS00075	COG0305	Participates in initiation and elongation during chromosome replication
BI282_RS00085	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BI282_RS00100	COG0745	RESPONSE REGULATOR receiver
BI282_RS00105	COG5002	protein histidine kinase activity
BI282_RS00110	COG4863	YycH protein
BI282_RS00120	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BI282_RS00130	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BI282_RS00140	COG2409	Drug exporters of the RND superfamily
BI282_RS00190	COG4175	Glycine betaine
BI282_RS00190	COG3448	diguanylate cyclase activity
BI282_RS00205	COG1280	lysine exporter protein (LysE YggA)
BI282_RS00255	COG1705	Flagellar rod assembly protein muramidase FlgJ
BI282_RS00255	COG3942	CHAP domain
BI282_RS00270	COG1064	alcohol dehydrogenase
BI282_RS00285	COG0402	S-adenosylhomocysteine deaminase activity
BI282_RS00290	COG1686	Belongs to the peptidase S11 family
BI282_RS00315	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BI282_RS00320	COG1609	Transcriptional regulator
BI282_RS00330	COG1869	D-ribose catabolic process
BI282_RS00360	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BI282_RS00370	COG0598	Magnesium transport protein CorA
BI282_RS00380	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BI282_RS00395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BI282_RS00400	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BI282_RS00405	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BI282_RS00430	COG0778	Nitroreductase
BI282_RS00445	COG1063	alcohol dehydrogenase
BI282_RS00465	COG2851	Citrate transporter
BI282_RS00480	COG2720	vancomycin resistance protein
BI282_RS00490	COG1250	3-hydroxyacyl-CoA dehydrogenase
BI282_RS00495	COG3246	L-lysine catabolic process to acetate
BI282_RS00505	COG0730	response to heat
BI282_RS00510	COG1937	Protein conserved in bacteria
BI282_RS00515	COG2210	Belongs to the sulfur carrier protein TusA family
BI282_RS00520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI282_RS00545	COG1012	belongs to the aldehyde dehydrogenase family
BI282_RS00550	COG0531	amino acid
BI282_RS00555	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BI282_RS00560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BI282_RS00570	COG0753	catalase activity
BI282_RS00575	COG0662	Cupin 2, conserved barrel domain protein
BI282_RS00595	COG0431	NADPH-dependent FMN reductase
BI282_RS00595	COG1053	succinate dehydrogenase
BI282_RS00595	COG3976	FMN-binding domain protein
BI282_RS00640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BI282_RS00640	COG2190	(PTS) system
BI282_RS00640	COG1263	PTS System
BI282_RS00650	COG2188	Transcriptional regulator
BI282_RS00655	COG2222	sugar isomerase
BI282_RS00665	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BI282_RS00665	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BI282_RS00670	COG3715	PTS system
BI282_RS00675	COG3716	PTS system mannose fructose sorbose family IID component
BI282_RS00685	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BI282_RS00690	COG1609	Transcriptional regulator
BI282_RS00700	COG1070	Carbohydrate kinase
BI282_RS00705	COG1063	alcohol dehydrogenase
BI282_RS00740	COG3181	Tripartite tricarboxylate transporter family receptor
BI282_RS00755	COG1966	Carbon starvation protein
BI282_RS00760	COG1054	Belongs to the UPF0176 family
BI282_RS00765	COG2388	GCN5-related N-acetyl-transferase
BI282_RS00780	COG2388	GCN5-related N-acetyl-transferase
BI282_RS00785	COG0346	lactoylglutathione lyase activity
BI282_RS00790	COG0789	Transcriptional regulator
BI282_RS00795	COG1664	Polymer-forming cytoskeletal
BI282_RS00805	COG0006	proline dipeptidase activity
BI282_RS00815	COG0477	Major facilitator Superfamily
BI282_RS00820	COG0667	Aldo Keto reductase
BI282_RS00865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BI282_RS00870	COG1028	Short-chain dehydrogenase reductase Sdr
BI282_RS00880	COG1288	antiporter activity
BI282_RS00895	COG3871	stress protein (general stress protein 26)
BI282_RS00900	COG1929	Belongs to the glycerate kinase type-1 family
BI282_RS00910	COG1511	domain protein
BI282_RS00930	COG0579	oxidoreductase
BI282_RS00940	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BI282_RS00945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BI282_RS00955	COG1757	Na H antiporter
BI282_RS00960	COG4195	phage-related replication protein
BI282_RS00985	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BI282_RS00995	COG2207	Transcriptional regulator
BI282_RS00995	COG1609	Transcriptional regulator
BI282_RS01000	COG4932	domain protein
BI282_RS01000	COG4932	domain protein
BI282_RS01060	COG0210	DNA helicase
BI282_RS01080	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BI282_RS01080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BI282_RS01080	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BI282_RS01085	COG3684	Belongs to the aldolase LacD family
BI282_RS01090	COG0508	dehydrogenase complex catalyzes the overall conversion of
BI282_RS01095	COG0022	dehydrogenase e1 component
BI282_RS01100	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BI282_RS01105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BI282_RS01125	COG1288	antiporter activity
BI282_RS01130	COG0549	Belongs to the carbamate kinase family
BI282_RS01135	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BI282_RS01185	COG0706	membrane insertase activity
BI282_RS01200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BI282_RS01205	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BI282_RS01235	COG4221	oxidoreductase activity
BI282_RS01240	COG0069	glutamate synthase activity
BI282_RS01245	COG2814	Major facilitator Superfamily
BI282_RS01250	COG4336	lyase activity
BI282_RS01275	COG0531	amino acid
BI282_RS01280	COG0753	catalase activity
BI282_RS01285	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BI282_RS01305	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BI282_RS01310	COG2011	ABC-type metal ion transport system permease component
BI282_RS01315	COG1464	Belongs to the NlpA lipoprotein family
BI282_RS01360	COG1309	transcriptional regulator
BI282_RS01365	COG2210	Belongs to the sulfur carrier protein TusA family
BI282_RS01375	COG3961	Belongs to the TPP enzyme family
BI282_RS01380	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BI282_RS01385	COG1510	regulation of RNA biosynthetic process
BI282_RS01390	COG1012	belongs to the aldehyde dehydrogenase family
BI282_RS01395	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
BI282_RS01400	COG3583	domain protein
BI282_RS01400	COG3583	domain protein
BI282_RS01410	COG1181	Belongs to the D-alanine--D-alanine ligase family
BI282_RS01420	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BI282_RS01455	COG0438	transferase activity, transferring glycosyl groups
BI282_RS01460	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BI282_RS01460	COG0463	Glycosyl transferase, family 2
BI282_RS01470	COG0494	nUDIX hydrolase
BI282_RS01480	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BI282_RS01485	COG3588	fructose-bisphosphate aldolase
BI282_RS01490	COG2258	MOSC domain
BI282_RS01520	COG1454	alcohol dehydrogenase
BI282_RS01520	COG1012	belongs to the aldehyde dehydrogenase family
BI282_RS01530	COG0640	Transcriptional regulator
BI282_RS01540	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BI282_RS01545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BI282_RS01545	COG1263	PTS System
BI282_RS01550	COG1737	Transcriptional regulator
BI282_RS01565	COG0640	Transcriptional regulator
BI282_RS01580	COG1131	(ABC) transporter
BI282_RS01605	COG0582	viral genome integration into host DNA
BI282_RS01610	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BI282_RS01610	COG2111	Na H antiporter
BI282_RS01615	COG2111	Na H antiporter
BI282_RS01620	COG1006	Multisubunit Na H antiporter MnhC subunit
BI282_RS01630	COG1863	multisubunit Na H antiporter MnhE subunit
BI282_RS01635	COG2212	antiporter activity
BI282_RS01640	COG1320	monovalent cation:proton antiporter activity
BI282_RS01650	COG1113	amino acid transport
BI282_RS01660	COG1131	(ABC) transporter
BI282_RS01670	COG2824	Alkylphosphonate utilization operon protein PhnA
BI282_RS01680	COG2376	Dihydroxyacetone kinase
BI282_RS01685	COG1461	Dihydroxyacetone kinase
BI282_RS01690	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
BI282_RS01695	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BI282_RS01705	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BI282_RS01720	COG0531	amino acid
BI282_RS01735	COG0463	Glycosyl transferase, family 2
BI282_RS01755	COG0446	pyridine nucleotide-disulphide oxidoreductase
BI282_RS01760	COG1131	(ABC) transporter
BI282_RS01780	COG1028	Short-chain dehydrogenase reductase Sdr
BI282_RS01800	COG0318	PFAM AMP-dependent synthetase and ligase
BI282_RS01805	COG0183	Belongs to the thiolase family
BI282_RS01815	COG2235	arginine
BI282_RS01825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BI282_RS01830	COG1438	arginine binding
BI282_RS01835	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BI282_RS01840	COG2022	thiamine diphosphate biosynthetic process
BI282_RS01850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BI282_RS01855	COG0352	thiamine-phosphate diphosphorylase activity
BI282_RS01875	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BI282_RS01890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BI282_RS01900	COG1131	(ABC) transporter
BI282_RS01915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BI282_RS01920	COG2508	Transcriptional regulator
BI282_RS01925	COG1953	Uracil, thiamine, allantoin
BI282_RS01930	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BI282_RS01940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BI282_RS01945	COG3257	ureidoglycine aminohydrolase activity
BI282_RS01950	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BI282_RS01955	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BI282_RS01960	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BI282_RS01965	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BI282_RS01980	COG2807	transmembrane transport
BI282_RS01985	COG5646	InterPro IPR014922
BI282_RS01990	COG2207	Transcriptional regulator
BI282_RS02005	COG2211	Major facilitator Superfamily
BI282_RS02010	COG1904	glucuronate isomerase
BI282_RS02015	COG1312	Catalyzes the dehydration of D-mannonate
BI282_RS02020	COG1028	Short-chain dehydrogenase reductase Sdr
BI282_RS02025	COG3250	beta-galactosidase activity
BI282_RS02045	COG1518	maintenance of DNA repeat elements
BI282_RS02070	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BI282_RS02075	COG1984	allophanate hydrolase subunit 2
BI282_RS02080	COG0511	ligase activity, forming carbon-carbon bonds
BI282_RS02085	COG0439	Biotin carboxylase
BI282_RS02090	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BI282_RS02095	COG1914	H( )-stimulated, divalent metal cation uptake system
BI282_RS02100	COG1070	Carbohydrate kinase
BI282_RS02115	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BI282_RS02160	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BI282_RS02180	COG3189	MarR family transcriptional regulator
BI282_RS02185	COG1882	Formate acetyltransferase
BI282_RS02200	COG0604	alcohol dehydrogenase
BI282_RS02200	COG3321	synthase
BI282_RS02210	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BI282_RS02220	COG3001	Fructosamine kinase
BI282_RS02240	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BI282_RS02255	COG3764	Sortase (surface protein transpeptidase)
BI282_RS02260	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BI282_RS02270	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BI282_RS02290	COG1136	(ABC) transporter
BI282_RS02295	COG0577	efflux transmembrane transporter activity
BI282_RS02300	COG0583	DNA-binding transcription factor activity
BI282_RS02305	COG1388	LysM domain
BI282_RS02310	COG1380	Effector of murein hydrolase LrgA
BI282_RS02320	COG0028	Belongs to the TPP enzyme family
BI282_RS02335	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BI282_RS02340	COG1687	branched-chain amino acid
BI282_RS02345	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
BI282_RS02355	COG1609	Transcriptional regulator
BI282_RS02370	COG1760	l-serine dehydratase
BI282_RS02375	COG1760	l-serine dehydratase
BI282_RS02380	COG2249	NAD(P)H dehydrogenase (quinone) activity
BI282_RS02385	COG0778	Nitroreductase
BI282_RS02395	COG1132	(ABC) transporter
BI282_RS02400	COG1132	(ABC) transporter
BI282_RS02415	COG0346	lactoylglutathione lyase activity
BI282_RS02420	COG2211	Major facilitator Superfamily
BI282_RS02425	COG2207	Transcriptional regulator
BI282_RS02430	COG3250	beta-galactosidase activity
BI282_RS02435	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
BI282_RS02440	COG1129	ABC transporter
BI282_RS02450	COG0586	Pfam SNARE associated Golgi protein
BI282_RS02455	COG2271	Major facilitator Superfamily
BI282_RS02465	COG3527	Alpha-acetolactate decarboxylase
BI282_RS02470	COG1289	transmembrane transporter activity
BI282_RS02475	COG4876	unkown
BI282_RS02480	COG0523	cobalamin synthesis protein
BI282_RS02485	COG2357	RelA SpoT domain protein
BI282_RS02495	COG1802	Transcriptional regulator
BI282_RS02505	COG2610	gluconate transmembrane transporter activity
BI282_RS02515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BI282_RS02520	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BI282_RS02550	COG4619	ABC transporter
BI282_RS02555	COG0390	transport system, permease component
BI282_RS02560	COG2814	Major facilitator Superfamily
BI282_RS02565	COG2272	Belongs to the type-B carboxylesterase lipase family
BI282_RS02570	COG0531	amino acid
BI282_RS02575	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
BI282_RS02585	COG1174	glycine betaine transport
BI282_RS02595	COG1174	glycine betaine transport
BI282_RS02605	COG1309	transcriptional regulator
BI282_RS02620	COG1346	cytolysis
BI282_RS02625	COG1380	Effector of murein hydrolase LrgA
BI282_RS02630	COG3279	Response regulator of the LytR AlgR family
BI282_RS02635	COG3275	phosphorelay sensor kinase activity
BI282_RS02645	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BI282_RS02655	COG1113	amino acid transport
BI282_RS02665	COG2814	Major facilitator Superfamily
BI282_RS02675	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BI282_RS02680	COG0588	phosphoglycerate mutase activity
BI282_RS02690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BI282_RS02695	COG0765	amino acid transport
BI282_RS02700	COG1126	abc transporter atp-binding protein
BI282_RS02740	COG2116	formate transmembrane transporter activity
BI282_RS02755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BI282_RS02765	COG1648	precorrin-2 dehydrogenase activity
BI282_RS02765	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BI282_RS02770	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
BI282_RS02775	COG1140	nitrate reductase beta subunit
BI282_RS02785	COG2181	nitrate reductase activity
BI282_RS02795	COG4585	Histidine kinase
BI282_RS02800	COG2197	response regulator
BI282_RS02805	COG2223	nitrite transmembrane transporter activity
BI282_RS02810	COG0772	Belongs to the SEDS family
BI282_RS02815	COG3425	synthase
BI282_RS02835	COG1846	Transcriptional regulator
BI282_RS02840	COG0778	Nitroreductase
BI282_RS02850	COG0697	spore germination
BI282_RS02855	COG1301	dicarboxylic acid transport
BI282_RS02865	COG1611	Belongs to the LOG family
BI282_RS02885	COG0492	ferredoxin-NADP+ reductase activity
BI282_RS02890	COG2814	Major facilitator Superfamily
BI282_RS02895	COG0604	alcohol dehydrogenase
BI282_RS02905	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BI282_RS02910	COG1620	l-lactate permease
BI282_RS02915	COG0438	transferase activity, transferring glycosyl groups
BI282_RS02925	COG5002	protein histidine kinase activity
BI282_RS02925	COG3850	Histidine kinase
BI282_RS02930	COG0745	RESPONSE REGULATOR receiver
BI282_RS02935	COG0577	efflux transmembrane transporter activity
BI282_RS02960	COG2814	Major facilitator Superfamily
BI282_RS02970	COG1566	PFAM secretion protein HlyD family protein
BI282_RS02975	COG2814	Major facilitator Superfamily
BI282_RS02980	COG2409	Drug exporters of the RND superfamily
BI282_RS02980	COG1033	growth of symbiont in host cell
BI282_RS02985	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BI282_RS02990	COG3314	Sporulation integral membrane protein YlbJ
BI282_RS03010	COG0598	Magnesium transport protein CorA
BI282_RS03015	COG1304	FMN binding
BI282_RS03030	COG0602	queuosine metabolic process
BI282_RS03035	COG2094	Belongs to the DNA glycosylase MPG family
BI282_RS03040	COG3152	Membrane
BI282_RS03060	COG4152	abc transporter atp-binding protein
BI282_RS03065	COG1668	transmembrane transport
BI282_RS03070	COG1742	UPF0060 membrane protein
BI282_RS03075	COG2017	converts alpha-aldose to the beta-anomer
BI282_RS03090	COG0010	Belongs to the arginase family
BI282_RS03095	COG0583	DNA-binding transcription factor activity
BI282_RS03100	COG3314	Sporulation integral membrane protein YlbJ
BI282_RS03105	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BI282_RS03110	COG1228	amidohydrolase
BI282_RS03115	COG0659	secondary active sulfate transmembrane transporter activity
BI282_RS03120	COG1473	amidohydrolase
BI282_RS03125	COG1028	Short-chain dehydrogenase reductase Sdr
BI282_RS03130	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BI282_RS03150	COG2271	Major facilitator Superfamily
BI282_RS03160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BI282_RS03185	COG1113	amino acid transport
BI282_RS03190	COG1737	Transcriptional regulator
BI282_RS03215	COG1316	TRANSCRIPTIONal
BI282_RS03225	COG3383	formate dehydrogenase (NAD+) activity
BI282_RS03250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BI282_RS03255	COG2076	Multidrug Resistance protein
BI282_RS03260	COG2076	Multidrug Resistance protein
BI282_RS03275	COG1757	Na H antiporter
BI282_RS03285	COG3942	CHAP domain
BI282_RS03325	COG0829	nickel cation binding
BI282_RS03335	COG0830	nickel cation binding
BI282_RS03340	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
BI282_RS03345	COG0804	urea catabolic process
BI282_RS03350	COG0832	Belongs to the urease beta subunit family
BI282_RS03355	COG0831	urea catabolic process
BI282_RS03365	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BI282_RS03370	COG1960	acyl-CoA dehydrogenase activity
BI282_RS03380	COG1268	BioY protein
BI282_RS03390	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BI282_RS03395	COG1609	Transcriptional regulator
BI282_RS03400	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BI282_RS03405	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BI282_RS03410	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
BI282_RS03415	COG0725	ABC transporter, periplasmic molybdate-binding protein
BI282_RS03420	COG4149	molybdate abc transporter
BI282_RS03425	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BI282_RS03430	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BI282_RS03435	COG0521	Mo-molybdopterin cofactor biosynthetic process
BI282_RS03440	COG0315	cyclic pyranopterin monophosphate synthase activity
BI282_RS03445	COG0303	'Molybdopterin
BI282_RS03455	COG0314	molybdopterin synthase activity
BI282_RS03465	COG0746	molybdenum cofactor guanylyltransferase activity
BI282_RS03470	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BI282_RS03480	COG1131	(ABC) transporter
BI282_RS03485	COG0842	Transport permease protein
BI282_RS03495	COG2197	response regulator
BI282_RS03500	COG2814	Major facilitator Superfamily
BI282_RS03520	COG2348	transferase activity, transferring amino-acyl groups
BI282_RS03525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BI282_RS03540	COG4975	Glucose uptake
BI282_RS03555	COG2252	PERMEase
BI282_RS03570	COG0051	transcription antitermination factor activity, RNA binding
BI282_RS03575	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BI282_RS03580	COG0088	Forms part of the polypeptide exit tunnel
BI282_RS03585	COG0089	rRNA binding
BI282_RS03590	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BI282_RS03595	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BI282_RS03600	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BI282_RS03605	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BI282_RS03610	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BI282_RS03620	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BI282_RS03625	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BI282_RS03630	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BI282_RS03635	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BI282_RS03640	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BI282_RS03645	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BI282_RS03650	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BI282_RS03655	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BI282_RS03660	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BI282_RS03665	COG1841	ribosomal large subunit assembly
BI282_RS03670	COG0200	Binds to the 23S rRNA
BI282_RS03675	COG0201	protein transport
BI282_RS03680	COG0563	adenylate kinase activity
BI282_RS03690	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BI282_RS03695	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BI282_RS03700	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BI282_RS03705	COG0202	RNA polymerase activity
BI282_RS03710	COG0203	ribosomal protein L17
BI282_RS03730	COG0101	tRNA pseudouridine synthase activity
BI282_RS03735	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BI282_RS03740	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BI282_RS03745	COG1442	glycosyl transferase family 8
BI282_RS03770	COG2213	PTS system mannitol-specific
BI282_RS03770	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BI282_RS03775	COG3775	system Galactitol-specific IIC component
BI282_RS03790	COG2318	DinB family
BI282_RS03795	COG2608	mercury ion transmembrane transporter activity
BI282_RS03805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BI282_RS03810	COG0574	Belongs to the PEP-utilizing enzyme family
BI282_RS03810	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BI282_RS03815	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BI282_RS03820	COG2130	NADP-dependent
BI282_RS03830	COG2130	NADP-dependent
BI282_RS03835	COG0604	alcohol dehydrogenase
BI282_RS03840	COG0604	alcohol dehydrogenase
BI282_RS03845	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BI282_RS03860	COG1302	Protein conserved in bacteria
BI282_RS03870	COG2814	Major facilitator Superfamily
BI282_RS03875	COG4264	IucA IucC family
BI282_RS03880	COG3457	Alanine racemase
BI282_RS03885	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BI282_RS03890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BI282_RS03895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BI282_RS03900	COG3314	Sporulation integral membrane protein YlbJ
BI282_RS03905	COG2329	Antibiotic biosynthesis monooxygenase
BI282_RS03920	COG1988	membrane-bound metal-dependent
BI282_RS03925	COG4284	Utp--glucose-1-phosphate uridylyltransferase
BI282_RS03930	COG1272	protein, Hemolysin III
BI282_RS03945	COG2814	Major facilitator Superfamily
BI282_RS03950	COG0489	protein tyrosine kinase activity
BI282_RS04000	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BI282_RS04005	COG4856	YbbR-like protein
BI282_RS04010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BI282_RS04015	COG0246	Mannitol dehydrogenase
BI282_RS04020	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BI282_RS04025	COG3711	transcriptional antiterminator
BI282_RS04035	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BI282_RS04060	COG0640	Transcriptional regulator
BI282_RS04065	COG0702	epimerase
BI282_RS04070	COG2186	Transcriptional regulator
BI282_RS04075	COG0247	lactate metabolic process
BI282_RS04080	COG1139	Iron-sulfur cluster binding protein
BI282_RS04085	COG1556	Lactate utilization protein
BI282_RS04090	COG1482	cell wall glycoprotein biosynthetic process
BI282_RS04110	COG0783	Belongs to the Dps family
BI282_RS04115	COG1876	peptidase activity
BI282_RS04120	COG0813	purine-nucleoside phosphorylase activity
BI282_RS04125	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BI282_RS04145	COG1854	S-ribosylhomocysteine lyase activity
BI282_RS04170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BI282_RS04175	COG3343	RNA polymerase activity
BI282_RS04180	COG0504	CTP synthase activity
BI282_RS04190	COG0191	fructose-bisphosphate aldolase activity
BI282_RS04195	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BI282_RS04200	COG1733	regulation of RNA biosynthetic process
BI282_RS04205	COG1012	belongs to the aldehyde dehydrogenase family
BI282_RS04210	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BI282_RS04215	COG0254	rRNA binding
BI282_RS04220	COG1435	thymidine kinase activity
BI282_RS04225	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BI282_RS04230	COG2890	protein-(glutamine-N5) methyltransferase activity
BI282_RS04235	COG0009	L-threonylcarbamoyladenylate synthase
BI282_RS04240	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BI282_RS04245	COG4475	Protein of unknown function (DUF436)
BI282_RS04250	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BI282_RS04255	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BI282_RS04260	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BI282_RS04270	COG0356	it plays a direct role in the translocation of protons across the membrane
BI282_RS04275	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BI282_RS04280	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BI282_RS04285	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BI282_RS04290	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BI282_RS04295	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BI282_RS04300	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BI282_RS04305	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BI282_RS04315	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BI282_RS04325	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BI282_RS04335	COG0629	single-stranded DNA binding
BI282_RS04340	COG1388	LysM domain
BI282_RS04350	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BI282_RS04360	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BI282_RS04365	COG0352	thiamine-phosphate diphosphorylase activity
BI282_RS04370	COG0706	membrane insertase activity
BI282_RS04375	COG0456	acetyltransferase
BI282_RS04380	COG1418	mRNA catabolic process
BI282_RS04385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI282_RS04390	COG1937	Protein conserved in bacteria
BI282_RS04405	COG2217	Heavy metal translocating P-type atpase
BI282_RS04410	COG0772	Belongs to the SEDS family
BI282_RS04415	COG1181	Belongs to the D-alanine--D-alanine ligase family
BI282_RS04420	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BI282_RS04425	COG0513	Belongs to the DEAD box helicase family
BI282_RS04440	COG3402	PFAM membrane-flanked domain
BI282_RS04445	COG0736	holo-[acyl-carrier-protein] synthase activity
BI282_RS04450	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BI282_RS04465	COG2208	phosphoserine phosphatase activity
BI282_RS04480	COG1191	sigma factor activity
BI282_RS04485	COG2183	response to ionizing radiation
BI282_RS04490	COG3091	SprT-like family
BI282_RS04520	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BI282_RS04530	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BI282_RS04535	COG0473	3-isopropylmalate dehydrogenase activity
BI282_RS04540	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BI282_RS04545	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BI282_RS04555	COG0028	Belongs to the TPP enzyme family
BI282_RS04560	COG0129	dihydroxy-acid dehydratase activity
BI282_RS04565	COG0802	atpase or kinase
BI282_RS04570	COG1214	PFAM Peptidase M22, glycoprotease
BI282_RS04575	COG0456	acetyltransferase
BI282_RS04580	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BI282_RS04585	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BI282_RS04590	COG0488	(ABC) transporter
BI282_RS04595	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BI282_RS04600	COG0425	Belongs to the sulfur carrier protein TusA family
BI282_RS04605	COG2391	methyltransferase activity
BI282_RS04610	COG1621	beta-fructofuranosidase activity
BI282_RS04630	COG4512	PFAM Accessory gene regulator B
BI282_RS04655	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BI282_RS04660	COG0459	protein refolding
BI282_RS04665	COG0582	viral genome integration into host DNA
BI282_RS04765	COG1725	Transcriptional regulator
BI282_RS04780	COG1131	(ABC) transporter
BI282_RS04810	COG1136	(ABC) transporter
BI282_RS04835	COG2706	6-phosphogluconolactonase activity
BI282_RS04840	COG0471	metal ion transport
BI282_RS04850	COG1335	isochorismatase
BI282_RS04855	COG1227	inorganic diphosphatase activity
BI282_RS04860	COG1012	belongs to the aldehyde dehydrogenase family
BI282_RS04865	COG0077	Prephenate dehydratase
BI282_RS04875	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BI282_RS04880	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BI282_RS04885	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BI282_RS04895	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BI282_RS04900	COG4496	protein, YerC YecD
BI282_RS04905	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
BI282_RS04915	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BI282_RS04920	COG4851	CamS sex pheromone cAM373 precursor
BI282_RS04930	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BI282_RS04935	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BI282_RS04940	COG0154	amidase activity
BI282_RS04945	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BI282_RS04950	COG1597	lipid kinase activity
BI282_RS04955	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BI282_RS04965	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BI282_RS04985	COG4129	membrane
BI282_RS04990	COG0024	Methionine aminopeptidase
BI282_RS05010	COG2197	response regulator
BI282_RS05015	COG0288	reversible hydration of carbon dioxide
BI282_RS05020	COG1295	ribonuclease BN
BI282_RS05035	COG4840	Belongs to the UPF0435 family
BI282_RS05040	COG2309	aminopeptidase activity
BI282_RS05045	COG1607	acyl-coa hydrolase
BI282_RS05050	COG0535	radical SAM domain protein
BI282_RS05055	COG0693	protein deglycase activity
BI282_RS05060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BI282_RS05065	COG2137	regulation of response to DNA damage stimulus
BI282_RS05075	COG1388	LysM domain
BI282_RS05075	COG1134	teichoic acid transport
BI282_RS05090	COG1988	membrane-bound metal-dependent
BI282_RS05100	COG3557	Belongs to the UPF0374 family
BI282_RS05110	COG4129	membrane
BI282_RS05115	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BI282_RS05120	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BI282_RS05125	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BI282_RS05130	COG0735	belongs to the Fur family
BI282_RS05285	COG0765	amino acid transport
BI282_RS05290	COG1126	abc transporter atp-binding protein
BI282_RS05295	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BI282_RS05300	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BI282_RS05310	COG0363	glucosamine-6-phosphate deaminase activity
BI282_RS05320	COG0114	fumarate hydratase activity
BI282_RS05325	COG0564	pseudouridine synthase activity
BI282_RS05330	COG2203	Gaf domain
BI282_RS05330	COG4585	Histidine kinase
BI282_RS05335	COG2197	response regulator
BI282_RS05350	COG4399	Belongs to the UPF0754 family
BI282_RS05360	COG0420	3'-5' exonuclease activity
BI282_RS05370	COG3481	metal-dependent phosphohydrolase, HD sub domain
BI282_RS05380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BI282_RS05395	COG0537	adenosine 5'-monophosphoramidase activity
BI282_RS05400	COG1131	(ABC) transporter
BI282_RS05415	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BI282_RS05420	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BI282_RS05425	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BI282_RS05435	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BI282_RS05440	COG0157	Belongs to the NadC ModD family
BI282_RS05445	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BI282_RS05455	COG1827	regulation of RNA biosynthetic process
BI282_RS05530	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BI282_RS05535	COG0494	nUDIX hydrolase
BI282_RS05540	COG1506	peptidase
BI282_RS05545	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BI282_RS05550	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BI282_RS05560	COG0656	L-ascorbic acid biosynthetic process
BI282_RS05565	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BI282_RS05580	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BI282_RS05595	COG1595	DNA-templated transcription, initiation
BI282_RS05610	COG5632	N-Acetylmuramoyl-L-alanine amidase
BI282_RS05610	COG4193	domain, Protein
BI282_RS05610	COG3266	domain, Protein
BI282_RS05620	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BI282_RS05620	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BI282_RS05625	COG0307	riboflavin synthase, alpha
BI282_RS05635	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BI282_RS05645	COG2267	carboxylic ester hydrolase activity
BI282_RS05650	COG0039	L-malate dehydrogenase activity
BI282_RS05655	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BI282_RS05660	COG1242	4 iron, 4 sulfur cluster binding
BI282_RS05665	COG2814	Major facilitator Superfamily
BI282_RS05675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BI282_RS05680	COG2081	HI0933 family
BI282_RS05685	COG2244	polysaccharide biosynthetic process
BI282_RS05690	COG1187	pseudouridine synthase activity
BI282_RS05700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BI282_RS05710	COG2081	HI0933 family
BI282_RS05715	COG2244	polysaccharide biosynthetic process
BI282_RS05720	COG1187	pseudouridine synthase activity
BI282_RS05730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BI282_RS05740	COG0510	thiamine kinase activity
BI282_RS05745	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BI282_RS05750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI282_RS05760	COG1363	Peptidase, m42
BI282_RS05765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI282_RS05770	COG4848	Belongs to the UPF0354 family
BI282_RS05775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BI282_RS05780	COG1674	ftsk spoiiie
BI282_RS05785	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BI282_RS05790	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
BI282_RS05800	COG1605	Chorismate mutase
BI282_RS05800	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BI282_RS05805	COG1609	Transcriptional regulator
BI282_RS05815	COG0454	-acetyltransferase
BI282_RS05820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BI282_RS05825	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BI282_RS05835	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BI282_RS05840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BI282_RS05845	COG0204	Acyl-transferase
BI282_RS05855	COG1263	PTS System
BI282_RS05855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BI282_RS05865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BI282_RS05870	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BI282_RS05875	COG1764	response to oxidative stress
BI282_RS05880	COG0584	glycerophosphoryl diester phosphodiesterase
BI282_RS05890	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BI282_RS05895	COG1956	GAF domain-containing protein
BI282_RS05900	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BI282_RS05905	COG1104	cysteine desulfurase activity
BI282_RS05910	COG0301	tRNA thio-modification
BI282_RS05915	COG0730	response to heat
BI282_RS05920	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BI282_RS05925	COG0827	DNA restriction-modification system
BI282_RS05930	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BI282_RS05935	COG0589	response to stress
BI282_RS05945	COG0006	proline dipeptidase activity
BI282_RS05950	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BI282_RS05960	COG4109	DRTGG domain
BI282_RS05965	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BI282_RS05970	COG0587	DNA-directed DNA polymerase activity
BI282_RS05975	COG0281	malic enzyme
BI282_RS05980	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BI282_RS05985	COG0825	malonyl-CoA metabolic process
BI282_RS05990	COG0205	6-phosphofructokinase activity
BI282_RS05995	COG0469	pyruvate kinase activity
BI282_RS06000	COG1113	amino acid transport
BI282_RS06005	COG0372	Belongs to the citrate synthase family
BI282_RS06010	COG0538	isocitrate dehydrogenase activity
BI282_RS06015	COG0745	RESPONSE REGULATOR receiver
BI282_RS06020	COG5002	protein histidine kinase activity
BI282_RS06025	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BI282_RS06025	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BI282_RS06035	COG0237	dephospho-CoA kinase activity
BI282_RS06045	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BI282_RS06055	COG1484	DNA-dependent DNA replication
BI282_RS06060	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BI282_RS06065	COG0833	amino acid
BI282_RS06070	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BI282_RS06075	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BI282_RS06080	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BI282_RS06085	COG4112	unkown
BI282_RS06095	COG0544	peptidyl-prolyl cis-trans isomerase activity
BI282_RS06100	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BI282_RS06105	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BI282_RS06110	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BI282_RS06115	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BI282_RS06120	COG0181	hydroxymethylbilane synthase activity
BI282_RS06135	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BI282_RS06145	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BI282_RS06160	COG2818	Glycosylase
BI282_RS06165	COG0525	valine-tRNA ligase activity
BI282_RS06170	COG0285	dihydrofolate synthase activity
BI282_RS06180	COG2003	Belongs to the UPF0758 family
BI282_RS06205	COG2868	ribosomal protein
BI282_RS06215	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BI282_RS06220	COG4492	Belongs to the UPF0735 family
BI282_RS06225	COG0632	four-way junction helicase activity
BI282_RS06230	COG2255	four-way junction helicase activity
BI282_RS06240	COG0343	queuine tRNA-ribosyltransferase activity
BI282_RS06245	COG1862	Preprotein translocase
BI282_RS06250	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BI282_RS06250	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BI282_RS06255	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BI282_RS06255	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BI282_RS06260	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BI282_RS06270	COG1490	D-aminoacyl-tRNA deacylase activity
BI282_RS06275	COG0860	N-Acetylmuramoyl-L-alanine amidase
BI282_RS06280	COG0124	histidyl-tRNA synthetase
BI282_RS06285	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BI282_RS06295	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BI282_RS06300	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BI282_RS06305	COG1959	2 iron, 2 sulfur cluster binding
BI282_RS06315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BI282_RS06320	COG1104	cysteine desulfurase activity
BI282_RS06325	COG0482	sulfurtransferase activity
BI282_RS06335	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BI282_RS06340	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BI282_RS06345	COG4472	Bacterial protein of unknown function (DUF965)
BI282_RS06350	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BI282_RS06360	COG4122	O-methyltransferase activity
BI282_RS06365	COG0826	peptidase U32
BI282_RS06370	COG0826	peptidase U32
BI282_RS06375	COG0572	uridine kinase
BI282_RS06380	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BI282_RS06385	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BI282_RS06390	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BI282_RS06395	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BI282_RS06400	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BI282_RS06405	COG1534	Rna-binding protein
BI282_RS06415	COG1713	HD superfamily hydrolase involved in NAD metabolism
BI282_RS06420	COG0799	negative regulation of ribosome biogenesis
BI282_RS06430	COG1555	photosystem II stabilization
BI282_RS06430	COG1596	polysaccharide export
BI282_RS06435	COG2131	deaminase
BI282_RS06440	COG0658	competence protein
BI282_RS06440	COG2333	competence protein COMEC
BI282_RS06450	COG0268	Binds directly to 16S ribosomal RNA
BI282_RS06455	COG0481	GTPase activity
BI282_RS06460	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BI282_RS06465	COG1420	regulation of RNA biosynthetic process
BI282_RS06470	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BI282_RS06475	COG0443	Heat shock 70 kDa protein
BI282_RS06480	COG0484	heat shock protein binding
BI282_RS06485	COG2264	protein methyltransferase activity
BI282_RS06490	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BI282_RS06495	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BI282_RS06510	COG4864	UPF0365 protein
BI282_RS06520	COG1702	phosphate starvation-inducible protein PhoH
BI282_RS06525	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BI282_RS06530	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BI282_RS06540	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BI282_RS06545	COG1381	Involved in DNA repair and RecF pathway recombination
BI282_RS06550	COG0423	glycine-tRNA ligase activity
BI282_RS06555	COG0517	IMP dehydrogenase activity
BI282_RS06560	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BI282_RS06570	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BI282_RS06575	COG2384	SAM-dependent methyltransferase
BI282_RS06585	COG0513	Belongs to the DEAD box helicase family
BI282_RS06590	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BI282_RS06595	COG1121	(ABC) transporter
BI282_RS06600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BI282_RS06605	COG0735	belongs to the Fur family
BI282_RS06615	COG0768	penicillin binding
BI282_RS06620	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BI282_RS06630	COG4483	Protein conserved in bacteria
BI282_RS06635	COG1940	carbohydrate kinase activity
BI282_RS06640	COG0011	TIGRFAM Protein of
BI282_RS06645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BI282_RS06650	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BI282_RS06655	COG1459	type II secretion system
BI282_RS06685	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BI282_RS06690	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BI282_RS06695	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BI282_RS06705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BI282_RS06710	COG0095	Lipoate-protein ligase
BI282_RS06725	COG0006	proline dipeptidase activity
BI282_RS06730	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BI282_RS06735	COG0511	ligase activity, forming carbon-carbon bonds
BI282_RS06740	COG0439	Biotin carboxylase
BI282_RS06750	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BI282_RS06755	COG1570	exodeoxyribonuclease VII activity
BI282_RS06760	COG1722	exodeoxyribonuclease VII activity
BI282_RS06770	COG1438	arginine binding
BI282_RS06775	COG0497	DNA recombination
BI282_RS06780	COG0280	phosphate acetyltransferase
BI282_RS06790	COG3426	butyrate kinase activity
BI282_RS06795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BI282_RS06800	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BI282_RS06805	COG0022	dehydrogenase e1 component
BI282_RS06810	COG0508	dehydrogenase complex catalyzes the overall conversion of
BI282_RS06820	COG4129	membrane
BI282_RS06825	COG2195	Cleaves the N-terminal amino acid of tripeptides
BI282_RS06840	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BI282_RS06845	COG1234	tRNA 3'-trailer cleavage
BI282_RS06855	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BI282_RS06865	COG0667	Aldo Keto reductase
BI282_RS06875	COG0735	belongs to the Fur family
BI282_RS06880	COG4974	Belongs to the 'phage' integrase family
BI282_RS06890	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BI282_RS06895	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BI282_RS06900	COG1187	pseudouridine synthase activity
BI282_RS06905	COG0745	RESPONSE REGULATOR receiver
BI282_RS06920	COG1141	Ferredoxin
BI282_RS06930	COG0514	ATP-dependent DNA helicase (RecQ)
BI282_RS06940	COG0492	ferredoxin-NADP+ reductase activity
BI282_RS06950	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BI282_RS06960	COG1160	GTP binding
BI282_RS06965	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BI282_RS06980	COG2226	methyltransferase
BI282_RS06985	COG0142	geranyltranstransferase activity
BI282_RS06990	COG0105	UTP biosynthetic process
BI282_RS06995	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BI282_RS07000	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BI282_RS07005	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BI282_RS07015	COG5582	Belongs to the UPF0302 family
BI282_RS07020	COG4347	Protein of unknown function (DUF1405)
BI282_RS07025	COG2738	Putative neutral zinc metallopeptidase
BI282_RS07030	COG1694	Mazg nucleotide pyrophosphohydrolase
BI282_RS07035	COG0438	transferase activity, transferring glycosyl groups
BI282_RS07040	COG0617	tRNA 3'-terminal CCA addition
BI282_RS07050	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BI282_RS07050	COG1199	ATP-dependent helicase activity
BI282_RS07055	COG0017	Asparaginyl-tRNA synthetase
BI282_RS07060	COG3935	DnaD domain protein
BI282_RS07065	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BI282_RS07080	COG4499	WXG100 protein secretion system (Wss), protein YukC
BI282_RS07080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BI282_RS07085	COG3331	DNA recombination
BI282_RS07095	COG4474	Belongs to the UPF0398 family
BI282_RS07100	COG3599	regulation of cell shape
BI282_RS07110	COG0116	Belongs to the methyltransferase superfamily
BI282_RS07115	COG2962	Rard protein
BI282_RS07120	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BI282_RS07125	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BI282_RS07130	COG0328	RNA-DNA hybrid ribonuclease activity
BI282_RS07135	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BI282_RS07145	COG1413	lyase activity
BI282_RS07175	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BI282_RS07180	COG2190	(PTS) system
BI282_RS07200	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BI282_RS07205	COG0671	phosphoesterase, PA-phosphatase related
BI282_RS07210	COG0745	RESPONSE REGULATOR receiver
BI282_RS07215	COG5002	protein histidine kinase activity
BI282_RS07220	COG0567	Dehydrogenase, E1 component
BI282_RS07245	COG0714	Associated with various cellular activities
BI282_RS07250	COG4548	von Willebrand factor, type A
BI282_RS07255	COG1114	Component of the transport system for branched-chain amino acids
BI282_RS07260	COG1597	lipid kinase activity
BI282_RS07265	COG3853	Toxic anion resistance protein (TelA)
BI282_RS07285	COG1278	Cold shock
BI282_RS07300	COG1473	amidohydrolase
BI282_RS07310	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BI282_RS07315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BI282_RS07320	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BI282_RS07330	COG0488	(ABC) transporter
BI282_RS07335	COG2996	Protein conserved in bacteria
BI282_RS07340	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BI282_RS07345	COG0573	inorganic phosphate transmembrane transporter activity
BI282_RS07350	COG0581	inorganic phosphate transmembrane transporter activity
BI282_RS07355	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BI282_RS07360	COG0704	Plays a role in the regulation of phosphate uptake
BI282_RS07375	COG0747	negative chemotaxis
BI282_RS07405	COG2348	transferase activity, transferring amino-acyl groups
BI282_RS07410	COG2348	transferase activity, transferring amino-acyl groups
BI282_RS07415	COG0159	tryptophan synthase activity
BI282_RS07420	COG0133	tryptophan synthase activity
BI282_RS07425	COG0135	phosphoribosylanthranilate isomerase activity
BI282_RS07430	COG0134	indole-3-glycerol-phosphate synthase activity
BI282_RS07435	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BI282_RS07440	COG0512	Glutamine amidotransferase of anthranilate synthase
BI282_RS07445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BI282_RS07450	COG1363	Peptidase, m42
BI282_RS07455	COG0287	Prephenate dehydrogenase
BI282_RS07460	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BI282_RS07480	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BI282_RS07495	COG0628	permease
BI282_RS07500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BI282_RS07500	COG2190	(PTS) system
BI282_RS07500	COG1263	PTS System
BI282_RS07505	COG2190	(PTS) system
BI282_RS07505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BI282_RS07505	COG1263	PTS System
BI282_RS07510	COG3711	transcriptional antiterminator
BI282_RS07515	COG1115	amino acid carrier protein
BI282_RS07520	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BI282_RS07535	COG4841	protein insertion into membrane
BI282_RS07545	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BI282_RS07550	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BI282_RS07555	COG1970	mechanosensitive ion channel activity
BI282_RS07560	COG0419	ATPase involved in DNA repair
BI282_RS07565	COG0420	3'-5' exonuclease activity
BI282_RS07570	COG4846	Membrane protein involved in cytochrome C biogenesis
BI282_RS07575	COG3763	UPF0154 protein
BI282_RS07580	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BI282_RS07585	COG4224	UPF0291 protein
BI282_RS07595	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BI282_RS07605	COG2249	NAD(P)H dehydrogenase (quinone) activity
BI282_RS07615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BI282_RS07620	COG1621	beta-fructofuranosidase activity
BI282_RS07625	COG1609	Transcriptional regulator
BI282_RS07630	COG2340	Cysteine-rich secretory protein family
BI282_RS07635	COG0516	GMP reductase activity
BI282_RS07640	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BI282_RS07650	COG0833	amino acid
BI282_RS07665	COG0083	homoserine kinase activity
BI282_RS07670	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BI282_RS07675	COG0460	homoserine dehydrogenase
BI282_RS07680	COG0527	aspartate kinase activity
BI282_RS07705	COG1525	nuclease
BI282_RS07715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BI282_RS07720	COG0789	Transcriptional regulator
BI282_RS07740	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BI282_RS07745	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BI282_RS07750	COG0386	Belongs to the glutathione peroxidase family
BI282_RS07790	COG5632	N-Acetylmuramoyl-L-alanine amidase
BI282_RS07790	COG1388	LysM domain
BI282_RS07955	COG1484	DNA-dependent DNA replication
BI282_RS08015	COG3617	BRO family, N-terminal domain
BI282_RS08055	COG0582	viral genome integration into host DNA
BI282_RS08060	COG1923	regulation of RNA biosynthetic process
BI282_RS08065	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BI282_RS08075	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BI282_RS08080	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BI282_RS08085	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BI282_RS08095	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BI282_RS08100	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BI282_RS08105	COG0584	glycerophosphoryl diester phosphodiesterase
BI282_RS08115	COG4550	Control of competence regulator ComK, YlbF/YmcA
BI282_RS08120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BI282_RS08125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BI282_RS08130	COG0601	transmembrane transport
BI282_RS08135	COG4608	Belongs to the ABC transporter superfamily
BI282_RS08140	COG0444	Belongs to the ABC transporter superfamily
BI282_RS08145	COG0747	negative chemotaxis
BI282_RS08160	COG1013	pyruvate-flavodoxin oxidoreductase activity
BI282_RS08165	COG0674	pyruvate-flavodoxin oxidoreductase activity
BI282_RS08165	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BI282_RS08170	COG1692	metallophosphoesterase
BI282_RS08180	COG0583	DNA-binding transcription factor activity
BI282_RS08190	COG1418	mRNA catabolic process
BI282_RS08195	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BI282_RS08200	COG1546	Belongs to the CinA family
BI282_RS08200	COG1058	Belongs to the CinA family
BI282_RS08220	COG0300	oxidoreductase activity
BI282_RS08225	COG0612	Peptidase, M16
BI282_RS08230	COG0612	Peptidase, M16
BI282_RS08235	COG2188	Transcriptional regulator
BI282_RS08245	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BI282_RS08255	COG1185	polyribonucleotide nucleotidyltransferase activity
BI282_RS08260	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BI282_RS08265	COG0196	riboflavin kinase activity
BI282_RS08270	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BI282_RS08280	COG5002	protein histidine kinase activity
BI282_RS08280	COG3850	Histidine kinase
BI282_RS08285	COG0745	RESPONSE REGULATOR receiver
BI282_RS08300	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BI282_RS08310	COG0584	glycerophosphoryl diester phosphodiesterase
BI282_RS08320	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BI282_RS08325	COG1358	cellular component organization or biogenesis
BI282_RS08330	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BI282_RS08335	COG0195	Participates in both transcription termination and antitermination
BI282_RS08340	COG0779	Required for maturation of 30S ribosomal subunits
BI282_RS08345	COG2176	DNA-directed DNA polymerase activity
BI282_RS08350	COG0442	prolyl-tRNA aminoacylation
BI282_RS08360	COG4589	Belongs to the CDS family
BI282_RS08370	COG0233	cytoplasmic translational termination
BI282_RS08375	COG0528	UMP kinase activity
BI282_RS08385	COG0052	Belongs to the universal ribosomal protein uS2 family
BI282_RS08390	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BI282_RS08395	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BI282_RS08400	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BI282_RS08405	COG4974	Belongs to the 'phage' integrase family
BI282_RS08410	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BI282_RS08415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BI282_RS08420	COG0758	DNA mediated transformation
BI282_RS08425	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BI282_RS08430	COG0045	succinate-CoA ligase (ADP-forming) activity
BI282_RS08435	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BI282_RS08450	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BI282_RS08455	COG4485	Bacterial membrane protein, YfhO
BI282_RS08470	COG0335	large ribosomal subunit rRNA binding
BI282_RS08475	COG0336	Belongs to the RNA methyltransferase TrmD family
BI282_RS08480	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BI282_RS08485	COG0228	four-way junction DNA binding
BI282_RS08490	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BI282_RS08495	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BI282_RS08500	COG0552	protein localization to endoplasmic reticulum
BI282_RS08505	COG1196	nuclear chromosome segregation
BI282_RS08510	COG0571	ribonuclease III activity
BI282_RS08515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BI282_RS08530	COG0416	fatty acid biosynthetic process
BI282_RS08535	COG1349	DNA-binding transcription factor activity
BI282_RS08545	COG1760	l-serine dehydratase
BI282_RS08550	COG1760	l-serine dehydratase
BI282_RS08555	COG1461	Dihydroxyacetone kinase
BI282_RS08560	COG1302	Protein conserved in bacteria
BI282_RS08570	COG1564	THIamine pyrophosphokinase
BI282_RS08575	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BI282_RS08580	COG1162	GTPase activity
BI282_RS08590	COG0631	protein serine/threonine phosphatase activity
BI282_RS08595	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BI282_RS08600	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BI282_RS08600	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BI282_RS08605	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BI282_RS08625	COG2910	NAD(P)H-binding
BI282_RS08630	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BI282_RS08635	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BI282_RS08645	COG1758	RNA polymerase activity
BI282_RS08650	COG0194	GDP metabolic process
BI282_RS08665	COG1316	TRANSCRIPTIONal
BI282_RS08670	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BI282_RS08675	COG0110	maltose O-acetyltransferase activity
BI282_RS08680	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BI282_RS08705	COG0463	Glycosyl transferase, family 2
BI282_RS08705	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BI282_RS08710	COG0297	glycogen (starch) synthase activity
BI282_RS08715	COG1045	serine acetyltransferase
BI282_RS08755	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BI282_RS08760	COG0284	orotidine-5'-phosphate decarboxylase activity
BI282_RS08765	COG0167	dihydroorotate dehydrogenase activity
BI282_RS08770	COG0543	2 iron, 2 sulfur cluster binding
BI282_RS08775	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BI282_RS08780	COG0505	Belongs to the CarA family
BI282_RS08790	COG0540	Belongs to the ATCase OTCase family
BI282_RS08800	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BI282_RS08815	COG1518	maintenance of DNA repeat elements
BI282_RS08830	COG0564	pseudouridine synthase activity
BI282_RS08835	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BI282_RS08845	COG2514	catechol 2,3-dioxygenase activity
BI282_RS08850	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BI282_RS08855	COG3599	regulation of cell shape
BI282_RS08865	COG0762	integral membrane protein
BI282_RS08870	COG1799	cell septum assembly
BI282_RS08875	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BI282_RS08890	COG0849	cell division
BI282_RS08900	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BI282_RS08905	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BI282_RS08910	COG0768	penicillin binding
BI282_RS08915	COG4839	cell division protein FtsL
BI282_RS08920	COG0275	rRNA processing
BI282_RS08925	COG2001	Belongs to the MraZ family
BI282_RS08930	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
BI282_RS08935	COG0454	-acetyltransferase
BI282_RS08940	COG1011	Hydrolase
BI282_RS08975	COG2176	DNA-directed DNA polymerase activity
BI282_RS08990	COG0346	lactoylglutathione lyase activity
BI282_RS09005	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BI282_RS09015	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BI282_RS09020	COG1053	succinate dehydrogenase
BI282_RS09025	COG2009	succinate dehydrogenase
BI282_RS09030	COG0322	excinuclease ABC activity
BI282_RS09035	COG3118	belongs to the thioredoxin family
BI282_RS09040	COG1193	negative regulation of DNA recombination
BI282_RS09045	COG1796	DNA polymerase
BI282_RS09045	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BI282_RS09060	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BI282_RS09065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BI282_RS09065	COG0072	phenylalanine-tRNA ligase activity
BI282_RS09070	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BI282_RS09075	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BI282_RS09080	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BI282_RS09095	COG1323	Belongs to the UPF0348 family
BI282_RS09105	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BI282_RS09110	COG0742	ribosomal rna small subunit methyltransferase
BI282_RS09125	COG0584	glycerophosphoryl diester phosphodiesterase
BI282_RS09130	COG3679	Belongs to the UPF0342 family
BI282_RS09145	COG0109	protoheme IX farnesyltransferase activity
BI282_RS09150	COG1612	heme a metabolic process
BI282_RS09160	COG0772	Belongs to the SEDS family
BI282_RS09165	COG4838	Belongs to the UPF0358 family
BI282_RS09170	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BI282_RS09180	COG1217	gtp-binding protein TYPA
BI282_RS09190	COG0483	inositol monophosphate 1-phosphatase activity
BI282_RS09195	COG4493	Belongs to the UPF0637 family
BI282_RS09200	COG1914	H( )-stimulated, divalent metal cation uptake system
BI282_RS09220	COG1177	transmembrane transport
BI282_RS09225	COG1176	ABC-type spermidine putrescine transport system, permease component I
BI282_RS09240	COG4476	Belongs to the UPF0223 family
BI282_RS09270	COG0242	peptide deformylase activity
BI282_RS09280	COG5503	Protein of unknown function (DUF1447)
BI282_RS09290	COG0569	domain protein
BI282_RS09295	COG1294	oxidase, subunit
BI282_RS09300	COG1271	oxidase subunit
BI282_RS09310	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BI282_RS09325	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BI282_RS09340	COG1122	ATPase activity
BI282_RS09345	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BI282_RS09355	COG0151	Belongs to the GarS family
BI282_RS09360	COG0138	bifunctional purine biosynthesis protein purh
BI282_RS09370	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BI282_RS09375	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BI282_RS09380	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BI282_RS09385	COG0047	phosphoribosylformylglycinamidine synthase activity
BI282_RS09390	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BI282_RS09395	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BI282_RS09400	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BI282_RS09405	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BI282_RS09410	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BI282_RS09415	COG1363	Peptidase, m42
BI282_RS09420	COG1017	nitric oxide dioxygenase activity
BI282_RS09420	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BI282_RS09430	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BI282_RS09440	COG1845	cytochrome c oxidase, subunit III
BI282_RS09445	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BI282_RS09455	COG1349	DNA-binding transcription factor activity
BI282_RS09465	COG0698	ribose 5-phosphate isomerase
BI282_RS09470	COG1105	Belongs to the carbohydrate kinase PfkB family
BI282_RS09490	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BI282_RS09495	COG2723	6-phospho-beta-galactosidase activity
BI282_RS09500	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BI282_RS09500	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BI282_RS09505	COG1447	Phosphotransferase system cellobiose-specific component IIA
BI282_RS09525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BI282_RS09530	COG1959	2 iron, 2 sulfur cluster binding
BI282_RS09540	COG1316	TRANSCRIPTIONal
BI282_RS09570	COG3594	Acyltransferase
BI282_RS09575	COG0436	Aminotransferase
BI282_RS09585	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BI282_RS09590	COG0596	Alpha beta hydrolase
BI282_RS09595	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BI282_RS09600	COG1169	isochorismate synthase
BI282_RS09605	COG1575	Belongs to the MenA family. Type 1 subfamily
BI282_RS09615	COG2314	TM2 domain
BI282_RS09630	COG4873	Protein conserved in bacteria
BI282_RS09665	COG4509	Sortase family
BI282_RS09670	COG1120	ATPase activity
BI282_RS09700	COG1129	ABC transporter
BI282_RS09725	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BI282_RS09730	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BI282_RS09735	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BI282_RS09740	COG0131	Imidazoleglycerol-phosphate dehydratase
BI282_RS09745	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BI282_RS09750	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BI282_RS09755	COG0107	imidazoleglycerol-phosphate synthase activity
BI282_RS09765	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BI282_RS09770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BI282_RS09775	COG0861	Integral membrane protein TerC family
BI282_RS09780	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BI282_RS09795	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BI282_RS09800	COG2814	Major facilitator Superfamily
BI282_RS09805	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BI282_RS09810	COG2382	esterase
BI282_RS09820	COG0628	permease
BI282_RS09825	COG2814	Major facilitator Superfamily
BI282_RS09835	COG0475	glutathione-regulated potassium exporter activity
BI282_RS09835	COG0569	domain protein
BI282_RS09840	COG2239	Acts as a magnesium transporter
BI282_RS09845	COG0564	pseudouridine synthase activity
BI282_RS09850	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BI282_RS09855	COG2357	RelA SpoT domain protein
BI282_RS09865	COG4116	CYTH
BI282_RS09870	COG2346	COG2346, Truncated hemoglobins
BI282_RS09895	COG1164	Oligoendopeptidase f
BI282_RS09900	COG4862	establishment of competence for transformation
BI282_RS09905	COG1393	Belongs to the ArsC family
BI282_RS09910	COG0180	Tryptophanyl-tRNA synthetase
BI282_RS09920	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BI282_RS09925	COG0454	-acetyltransferase
BI282_RS09930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BI282_RS09935	COG4166	transmembrane transport
BI282_RS09940	COG4608	Belongs to the ABC transporter superfamily
BI282_RS09945	COG0444	Belongs to the ABC transporter superfamily
BI282_RS09950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BI282_RS09955	COG0601	transmembrane transport
BI282_RS09970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BI282_RS09995	COG0561	phosphatase activity
BI282_RS10015	COG1074	ATP-dependent DNA helicase activity
BI282_RS10020	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BI282_RS10035	COG0398	Pfam SNARE associated Golgi protein
BI282_RS10040	COG0166	Belongs to the GPI family
BI282_RS10045	COG0137	argininosuccinate synthase activity
BI282_RS10050	COG0165	Argininosuccinate lyase
BI282_RS10060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BI282_RS10065	COG1012	belongs to the aldehyde dehydrogenase family
BI282_RS10070	COG1902	pentaerythritol trinitrate reductase activity
BI282_RS10075	COG1098	S1 RNA binding domain
BI282_RS10095	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BI282_RS10105	COG2111	Na H antiporter
BI282_RS10105	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BI282_RS10110	COG2111	Na H antiporter
BI282_RS10115	COG1006	Multisubunit Na H antiporter MnhC subunit
BI282_RS10120	COG0651	ATP synthesis coupled electron transport
BI282_RS10125	COG1863	multisubunit Na H antiporter MnhE subunit
BI282_RS10130	COG2212	antiporter activity
BI282_RS10145	COG2050	protein possibly involved in aromatic compounds catabolism
BI282_RS10150	COG2056	Na+-H+ antiporter family
BI282_RS10155	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BI282_RS10160	COG1252	NADH dehydrogenase
BI282_RS10165	COG0316	Belongs to the HesB IscA family
BI282_RS10170	COG4844	belongs to the
BI282_RS10175	COG1252	NADH dehydrogenase
BI282_RS10180	COG4837	Protein of unknown function (DUF1462)
BI282_RS10185	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BI282_RS10190	COG0789	Transcriptional regulator
BI282_RS10195	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
BI282_RS10200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BI282_RS10205	COG1696	Membrane protein involved in D-alanine export
BI282_RS10210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BI282_RS10220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BI282_RS10225	COG0647	UMP catabolic process
BI282_RS10230	COG2445	Protein of unknown function DUF86
BI282_RS10240	COG4470	Protein conserved in bacteria
BI282_RS10245	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BI282_RS10250	COG0737	Belongs to the 5'-nucleotidase family
BI282_RS10255	COG0730	response to heat
BI282_RS10260	COG1801	Protein of unknown function DUF72
BI282_RS10270	COG1253	flavin adenine dinucleotide binding
BI282_RS10290	COG0822	iron-sulfur transferase activity
BI282_RS10300	COG0719	Fe-S assembly protein
BI282_RS10305	COG0396	ATPase activity
BI282_RS10310	COG1464	Belongs to the NlpA lipoprotein family
BI282_RS10315	COG2011	ABC-type metal ion transport system permease component
BI282_RS10320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BI282_RS10325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI282_RS10330	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BI282_RS10335	COG0509	glycine decarboxylation via glycine cleavage system
BI282_RS10340	COG1393	Belongs to the ArsC family
BI282_RS10345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BI282_RS10355	COG0710	3-dehydroquinate dehydratase activity
BI282_RS10375	COG1704	LemA family
BI282_RS10380	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BI282_RS10390	COG1278	Cold shock
BI282_RS10395	COG0300	oxidoreductase activity
BI282_RS10400	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BI282_RS10415	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BI282_RS10420	COG0557	exoribonuclease II activity
BI282_RS10425	COG1647	Serine aminopeptidase, S33
BI282_RS10430	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BI282_RS10440	COG0148	phosphopyruvate hydratase activity
BI282_RS10445	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BI282_RS10455	COG0126	phosphoglycerate kinase activity
BI282_RS10485	COG0740	serine-type endopeptidase activity
BI282_RS10605	COG1114	Component of the transport system for branched-chain amino acids
BI282_RS10610	COG2814	Major facilitator Superfamily
BI282_RS10615	COG1481	regulation of sporulation
BI282_RS10620	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BI282_RS10625	COG1660	Displays ATPase and GTPase activities
BI282_RS10640	COG0110	maltose O-acetyltransferase activity
BI282_RS10645	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BI282_RS10650	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BI282_RS10655	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BI282_RS10675	COG3942	CHAP domain
BI282_RS10690	COG0653	protein targeting
BI282_RS10695	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BI282_RS10700	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BI282_RS10705	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BI282_RS10715	COG1739	Uncharacterized protein family UPF0029
BI282_RS10720	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BI282_RS10725	COG2199	diguanylate cyclase activity
BI282_RS10740	COG2195	Cleaves the N-terminal amino acid of tripeptides
BI282_RS10750	COG1929	Belongs to the glycerate kinase type-1 family
BI282_RS10770	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BI282_RS10780	COG4607	ABC-type enterochelin transport system periplasmic component
BI282_RS10785	COG4604	ABC transporter, ATP-binding protein
BI282_RS10790	COG4605	iron ion homeostasis
BI282_RS10795	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BI282_RS10800	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BI282_RS10805	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BI282_RS10810	COG1780	Probably involved in ribonucleotide reductase function
BI282_RS10820	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BI282_RS10825	COG3104	oligopeptide transport
BI282_RS10830	COG3104	oligopeptide transport
BI282_RS10840	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BI282_RS10845	COG1174	glycine betaine transport
BI282_RS10855	COG0514	ATP-dependent DNA helicase (RecQ)
BI282_RS10860	COG0488	(ABC) transporter
BI282_RS10865	COG1368	sulfuric ester hydrolase activity
BI282_RS10875	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BI282_RS10900	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BI282_RS10905	COG0720	synthase
BI282_RS10925	COG0656	L-ascorbic acid biosynthetic process
BI282_RS10935	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
BI282_RS10960	COG1253	flavin adenine dinucleotide binding
BI282_RS10965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BI282_RS10965	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BI282_RS10965	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BI282_RS10970	COG1105	Belongs to the carbohydrate kinase PfkB family
BI282_RS10975	COG1349	DNA-binding transcription factor activity
BI282_RS10980	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BI282_RS10990	COG0039	L-malate dehydrogenase activity
BI282_RS10995	COG1464	Belongs to the NlpA lipoprotein family
BI282_RS11015	COG0471	metal ion transport
BI282_RS11020	COG0039	L-malate dehydrogenase activity
BI282_RS11030	COG4989	oxidoreductase activity
BI282_RS11035	COG0523	cobalamin synthesis protein
BI282_RS11045	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BI282_RS11050	COG4988	ABC transporter
BI282_RS11055	COG1968	undecaprenyl-diphosphatase activity
BI282_RS11065	COG1671	Belongs to the UPF0178 family
BI282_RS11105	COG0583	DNA-binding transcription factor activity
BI282_RS11185	COG0217	transcriptional regulatory protein
BI282_RS11195	COG2207	Transcriptional regulator
BI282_RS11205	COG3942	CHAP domain
BI282_RS11205	COG1388	LysM domain
BI282_RS11210	COG0306	phosphate transporter
BI282_RS11215	COG1392	Phosphate transport regulator
BI282_RS11220	COG0577	efflux transmembrane transporter activity
BI282_RS11225	COG1136	(ABC) transporter
BI282_RS11230	COG2205	protein histidine kinase activity
BI282_RS11250	COG3949	Membrane
BI282_RS11260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BI282_RS11265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BI282_RS11270	COG1120	ATPase activity
BI282_RS11275	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BI282_RS11280	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BI282_RS11285	COG1132	(ABC) transporter
BI282_RS11290	COG1686	Belongs to the peptidase S11 family
BI282_RS11295	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BI282_RS11300	COG1216	Glycosyl transferase, family 2
BI282_RS11305	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BI282_RS11310	COG1682	transport, permease protein
BI282_RS11315	COG1134	teichoic acid transport
BI282_RS11320	COG5609	conserved protein (DUF2294)
BI282_RS11325	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BI282_RS11340	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
BI282_RS11355	COG1247	-acetyltransferase
BI282_RS11360	COG0671	phosphoesterase, PA-phosphatase related
BI282_RS11370	COG1121	(ABC) transporter
BI282_RS11375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BI282_RS11380	COG0803	Belongs to the bacterial solute-binding protein 9 family
BI282_RS11385	COG2348	transferase activity, transferring amino-acyl groups
BI282_RS11390	COG0025	NhaP-type Na H and K H
BI282_RS11435	COG0546	phosphoglycolate phosphatase activity
BI282_RS11440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BI282_RS11445	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BI282_RS11450	COG0018	arginyl-trna synthetase
BI282_RS11460	COG1473	amidohydrolase
BI282_RS11470	COG1078	dGTPase activity
BI282_RS11475	COG0519	Catalyzes the synthesis of GMP from XMP
BI282_RS11485	COG4844	belongs to the
BI282_RS11505	COG0095	Lipoate-protein ligase
BI282_RS11510	COG0280	phosphate acetyltransferase
BI282_RS11515	COG3253	May function as heme-dependent peroxidase
BI282_RS11535	COG0586	Pfam SNARE associated Golgi protein
BI282_RS11540	COG0531	amino acid
BI282_RS11545	COG2363	Small membrane protein
BI282_RS11555	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BI282_RS11565	COG1469	GTP cyclohydrolase I activity
BI282_RS11570	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BI282_RS11575	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BI282_RS11580	COG0363	glucosamine-6-phosphate deaminase activity
BI282_RS11585	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
BI282_RS11595	COG0431	NADPH-dependent FMN reductase
BI282_RS11600	COG0561	phosphatase activity
BI282_RS11610	COG1428	Deoxynucleoside kinase
BI282_RS11615	COG1428	Deoxynucleoside kinase
BI282_RS11620	COG0561	phosphatase activity
BI282_RS11630	COG0546	phosphoglycolate phosphatase activity
BI282_RS11635	COG2832	Protein of unknown function (DUF454)
BI282_RS11645	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BI282_RS11660	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
BI282_RS11665	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
BI282_RS11680	COG1473	amidohydrolase
BI282_RS11685	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BI282_RS11690	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BI282_RS11695	COG0049	tRNA binding
BI282_RS11700	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BI282_RS11710	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BI282_RS11715	COG0085	RNA polymerase activity
BI282_RS11720	COG2813	Specifically methylates the guanine in position
BI282_RS11725	COG0222	ribosome binding
BI282_RS11730	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BI282_RS11740	COG0081	regulation of translation
BI282_RS11745	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BI282_RS11750	COG0250	Participates in transcription elongation, termination and antitermination
BI282_RS11760	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BI282_RS11775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BI282_RS11780	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BI282_RS11785	COG0215	cysteine-tRNA ligase activity
BI282_RS11790	COG1045	serine acetyltransferase
BI282_RS11800	COG4956	integral membrane protein (PIN domain superfamily)
BI282_RS11805	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BI282_RS11810	COG0542	response to heat
BI282_RS11815	COG3869	Catalyzes the specific phosphorylation of arginine residues in
BI282_RS11820	COG3880	PFAM UvrB UvrC protein
BI282_RS11830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BI282_RS11845	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BI282_RS11850	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
BI282_RS11855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BI282_RS11865	COG2814	Major facilitator Superfamily
BI282_RS11950	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BI282_RS11955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BI282_RS11960	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BI282_RS11980	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BI282_RS11985	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BI282_RS12000	COG1098	S1 RNA binding domain
BI282_RS12010	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BI282_RS12015	COG3956	TIGRFAM MazG family protein
BI282_RS12020	COG2244	polysaccharide biosynthetic process
BI282_RS12025	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BI282_RS12030	COG0193	aminoacyl-tRNA hydrolase activity
BI282_RS12035	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BI282_RS12040	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BI282_RS12045	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BI282_RS12050	COG2088	sporulation resulting in formation of a cellular spore
BI282_RS12055	COG0251	oxidation-reduction process
BI282_RS12060	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BI282_RS12070	COG4466	Protein conserved in bacteria
BI282_RS12075	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BI282_RS12080	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BI282_RS12085	COG0084	hydrolase, TatD family'
BI282_RS12090	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BI282_RS12090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BI282_RS12170	COG1388	LysM domain
BI282_RS12170	COG3942	CHAP domain
BI282_RS12195	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BI282_RS12200	COG2827	Endonuclease containing a URI domain
BI282_RS12205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BI282_RS12215	COG1774	PSP1 C-terminal conserved region
BI282_RS12220	COG0470	DNA polymerase III
BI282_RS12225	COG3870	Protein conserved in bacteria
BI282_RS12230	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BI282_RS12235	COG1982	Orn Lys Arg decarboxylase major
BI282_RS12255	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BI282_RS12265	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BI282_RS12295	COG2814	Major facilitator Superfamily
BI282_RS12300	COG0583	DNA-binding transcription factor activity
BI282_RS12310	COG2188	Transcriptional regulator
BI282_RS12315	COG0366	Alpha amylase catalytic
BI282_RS12320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BI282_RS12320	COG1263	PTS System
BI282_RS12325	COG0346	lactoylglutathione lyase activity
BI282_RS12335	COG0493	'glutamate synthase
BI282_RS12340	COG0070	glutamate synthase
BI282_RS12340	COG0069	glutamate synthase activity
BI282_RS12340	COG0067	glutamate synthase
BI282_RS12345	COG0583	DNA-binding transcription factor activity
BI282_RS12370	COG4841	protein insertion into membrane
BI282_RS12380	COG0737	Belongs to the 5'-nucleotidase family
BI282_RS12385	COG2162	N-hydroxyarylamine O-acetyltransferase activity
BI282_RS12395	COG0626	cystathionine gamma-synthase activity
BI282_RS12400	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BI282_RS12405	COG1266	CAAX protease self-immunity
BI282_RS12410	COG0733	neurotransmitter:sodium symporter activity
BI282_RS12420	COG1647	Serine aminopeptidase, S33
BI282_RS12425	COG1755	Isoprenylcysteine carboxyl methyltransferase
BI282_RS12430	COG1279	arginine transmembrane transporter activity
BI282_RS12440	COG0346	lactoylglutathione lyase activity
BI282_RS12460	COG1695	Transcriptional regulator
BI282_RS12465	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BI282_RS12470	COG1683	Conserved Protein
BI282_RS12495	COG0529	Catalyzes the synthesis of activated sulfate
BI282_RS12500	COG2046	Belongs to the sulfate adenylyltransferase family
BI282_RS12505	COG0730	response to heat
BI282_RS12515	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BI282_RS12520	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BI282_RS12525	COG0175	sulfate reduction
BI282_RS12535	COG1216	Glycosyl transferase, family 2
BI282_RS12545	COG1051	belongs to the nudix hydrolase family
BI282_RS12560	COG2514	catechol 2,3-dioxygenase activity
BI282_RS12565	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BI282_RS12565	COG0519	Catalyzes the synthesis of GMP from XMP
BI282_RS12575	COG2233	PERMEase
BI282_RS12580	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BI282_RS12600	COG1823	symporter activity
BI282_RS12605	COG0778	Nitroreductase
BI282_RS12615	COG0450	alkyl hydroperoxide reductase
BI282_RS12620	COG3634	alkyl hydroperoxide reductase activity
BI282_RS12640	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BI282_RS12645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BI282_RS12670	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BI282_RS12695	COG0745	RESPONSE REGULATOR receiver
BI282_RS12700	COG5002	protein histidine kinase activity
BI282_RS12730	COG0360	Binds together with S18 to 16S ribosomal RNA
BI282_RS12750	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BI282_RS12770	COG0012	GTP binding
BI282_RS12775	COG4481	Protein conserved in bacteria
BI282_RS12780	COG0668	transmembrane transport
BI282_RS12785	COG1475	DNA binding
BI282_RS12790	COG0626	cystathionine gamma-synthase activity
BI282_RS12795	COG0646	methionine synthase
BI282_RS12795	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BI282_RS12800	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BI282_RS12810	COG0436	Aminotransferase
BI282_RS12820	COG1475	DNA binding
BI282_RS12825	COG0357	Ribosomal RNA small subunit methyltransferase G
BI282_RS12835	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BI282_RS12840	COG0594	ribonuclease P activity
BI282_RS12900	COG3152	Membrane
BI282_RS12965	COG3152	Membrane
BI282_RS13020	COG1131	(ABC) transporter
BI282_RS13060	COG1114	Component of the transport system for branched-chain amino acids
BI282_RS13080	COG0577	efflux transmembrane transporter activity
BI282_RS13110	COG1278	Cold shock
BI282_RS13235	COG3093	addiction module antidote protein HigA
BI282_RS13355	COG1278	Cold shock
BI282_RS13405	COG1192	Involved in chromosome partitioning
BI282_RS13420	COG1131	(ABC) transporter
BI282_RS13425	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BI282_RS13435	COG3227	Zinc metalloprotease (Elastase)
BI282_RS13465	COG0640	Transcriptional regulator
BI282_RS13570	COG1278	Cold shock
BI282_RS13605	COG1132	(ABC) transporter
BI282_RS13625	COG0515	serine threonine protein kinase
BI282_RS13635	COG1695	Transcriptional regulator
BI282_RS13670	COG1279	arginine transmembrane transporter activity
BI282_RS13765	COG1279	arginine transmembrane transporter activity