locus-tag	class	description
FGL66_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FGL66_RS00010	COG0592	DNA-directed DNA polymerase activity
FGL66_RS00015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FGL66_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FGL66_RS00030	COG0187	DNA topoisomerase II activity
FGL66_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FGL66_RS00040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FGL66_RS00055	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FGL66_RS00065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FGL66_RS00070	COG4241	membrane
FGL66_RS00075	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
FGL66_RS00080	COG0359	binds to the 23S rRNA
FGL66_RS00085	COG0305	Participates in initiation and elongation during chromosome replication
FGL66_RS00090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FGL66_RS00095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FGL66_RS00115	COG5002	protein histidine kinase activity
FGL66_RS00130	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FGL66_RS00180	COG0697	spore germination
FGL66_RS00205	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FGL66_RS00225	COG1876	peptidase activity
FGL66_RS00240	COG0702	epimerase
FGL66_RS00245	COG2130	NADP-dependent
FGL66_RS00250	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FGL66_RS00255	COG2814	Major facilitator Superfamily
FGL66_RS00255	COG0477	Major facilitator Superfamily
FGL66_RS00260	COG1070	Carbohydrate kinase
FGL66_RS00265	COG2115	Belongs to the xylose isomerase family
FGL66_RS00270	COG1940	carbohydrate kinase activity
FGL66_RS00270	COG1846	Transcriptional regulator
FGL66_RS00275	COG0656	L-ascorbic acid biosynthetic process
FGL66_RS00295	COG1136	(ABC) transporter
FGL66_RS00335	COG2188	Transcriptional regulator
FGL66_RS00340	COG0813	purine-nucleoside phosphorylase activity
FGL66_RS00345	COG2814	Major facilitator Superfamily
FGL66_RS00350	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FGL66_RS00375	COG0579	oxidoreductase
FGL66_RS00380	COG1620	l-lactate permease
FGL66_RS00385	COG1263	PTS System
FGL66_RS00385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FGL66_RS00390	COG0366	Alpha amylase catalytic
FGL66_RS00395	COG2188	Transcriptional regulator
FGL66_RS00410	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FGL66_RS00415	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FGL66_RS00420	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FGL66_RS00440	COG1982	Orn Lys Arg decarboxylase major
FGL66_RS00445	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FGL66_RS00450	COG3870	Protein conserved in bacteria
FGL66_RS00455	COG0470	DNA polymerase III
FGL66_RS00460	COG1774	PSP1 C-terminal conserved region
FGL66_RS00465	COG4467	Involved in initiation control of chromosome replication
FGL66_RS00470	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FGL66_RS00475	COG2827	Endonuclease containing a URI domain
FGL66_RS00480	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FGL66_RS00485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FGL66_RS00485	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FGL66_RS00490	COG0084	hydrolase, TatD family'
FGL66_RS00495	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
FGL66_RS00500	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FGL66_RS00505	COG4466	Protein conserved in bacteria
FGL66_RS00510	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FGL66_RS00515	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FGL66_RS00520	COG0251	oxidation-reduction process
FGL66_RS00525	COG2088	sporulation resulting in formation of a cellular spore
FGL66_RS00530	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FGL66_RS00535	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FGL66_RS00540	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FGL66_RS00545	COG1279	arginine transmembrane transporter activity
FGL66_RS00550	COG0193	aminoacyl-tRNA hydrolase activity
FGL66_RS00555	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FGL66_RS00560	COG2244	polysaccharide biosynthetic process
FGL66_RS00565	COG3956	TIGRFAM MazG family protein
FGL66_RS00570	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FGL66_RS00580	COG1098	S1 RNA binding domain
FGL66_RS00595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FGL66_RS00600	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FGL66_RS00620	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FGL66_RS00625	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FGL66_RS00715	COG1289	transmembrane transporter activity
FGL66_RS00720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FGL66_RS00725	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
FGL66_RS00730	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
FGL66_RS00735	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FGL66_RS00745	COG3880	PFAM UvrB UvrC protein
FGL66_RS00750	COG3869	Catalyzes the specific phosphorylation of arginine residues in
FGL66_RS00755	COG0542	response to heat
FGL66_RS00760	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FGL66_RS00765	COG4956	integral membrane protein (PIN domain superfamily)
FGL66_RS00780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FGL66_RS00785	COG1045	serine acetyltransferase
FGL66_RS00790	COG0215	cysteine-tRNA ligase activity
FGL66_RS00795	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
FGL66_RS00820	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FGL66_RS00825	COG0250	Participates in transcription elongation, termination and antitermination
FGL66_RS00830	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FGL66_RS00835	COG0081	regulation of translation
FGL66_RS00840	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FGL66_RS00850	COG2813	Specifically methylates the guanine in position
FGL66_RS00855	COG0085	RNA polymerase activity
FGL66_RS00860	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FGL66_RS00870	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FGL66_RS00875	COG0049	tRNA binding
FGL66_RS00880	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FGL66_RS00885	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FGL66_RS00890	COG1473	amidohydrolase
FGL66_RS00900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FGL66_RS00905	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FGL66_RS00915	COG1428	Deoxynucleoside kinase
FGL66_RS00920	COG1428	Deoxynucleoside kinase
FGL66_RS00930	COG0561	phosphatase activity
FGL66_RS00935	COG0431	NADPH-dependent FMN reductase
FGL66_RS00940	COG1469	GTP cyclohydrolase I activity
FGL66_RS00945	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FGL66_RS00960	COG1263	PTS System
FGL66_RS00960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FGL66_RS00960	COG2190	(PTS) system
FGL66_RS00965	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
FGL66_RS00970	COG0363	glucosamine-6-phosphate deaminase activity
FGL66_RS00975	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
FGL66_RS00980	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FGL66_RS00995	COG2508	Transcriptional regulator
FGL66_RS01000	COG1953	Uracil, thiamine, allantoin
FGL66_RS01005	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FGL66_RS01010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FGL66_RS01020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FGL66_RS01025	COG3257	ureidoglycine aminohydrolase activity
FGL66_RS01030	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
FGL66_RS01035	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
FGL66_RS01040	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FGL66_RS01045	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FGL66_RS01055	COG0549	Belongs to the carbamate kinase family
FGL66_RS01080	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FGL66_RS01090	COG2363	Small membrane protein
FGL66_RS01095	COG0531	amino acid
FGL66_RS01100	COG0095	Lipoate-protein ligase
FGL66_RS01115	COG0531	amino acid
FGL66_RS01130	COG0471	metal ion transport
FGL66_RS01135	COG4844	belongs to the
FGL66_RS01150	COG1078	dGTPase activity
FGL66_RS01170	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FGL66_RS01175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FGL66_RS01180	COG0546	phosphoglycolate phosphatase activity
FGL66_RS01225	COG0582	viral genome integration into host DNA
FGL66_RS01230	COG2111	Na H antiporter
FGL66_RS01230	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FGL66_RS01235	COG2111	Na H antiporter
FGL66_RS01240	COG1006	Multisubunit Na H antiporter MnhC subunit
FGL66_RS01250	COG1863	multisubunit Na H antiporter MnhE subunit
FGL66_RS01255	COG2212	antiporter activity
FGL66_RS01260	COG1320	monovalent cation:proton antiporter activity
FGL66_RS01265	COG0803	Belongs to the bacterial solute-binding protein 9 family
FGL66_RS01270	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FGL66_RS01275	COG1121	(ABC) transporter
FGL66_RS01290	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
FGL66_RS01295	COG1134	teichoic acid transport
FGL66_RS01300	COG1682	transport, permease protein
FGL66_RS01305	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FGL66_RS01310	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FGL66_RS01315	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FGL66_RS01320	COG1686	Belongs to the peptidase S11 family
FGL66_RS01325	COG1132	(ABC) transporter
FGL66_RS01340	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FGL66_RS01345	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FGL66_RS01350	COG1120	ATPase activity
FGL66_RS01355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FGL66_RS01360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FGL66_RS01370	COG0477	Major facilitator Superfamily
FGL66_RS01375	COG3949	Membrane
FGL66_RS01385	COG0745	RESPONSE REGULATOR receiver
FGL66_RS01395	COG1136	(ABC) transporter
FGL66_RS01400	COG0577	efflux transmembrane transporter activity
FGL66_RS01405	COG1392	Phosphate transport regulator
FGL66_RS01410	COG0306	phosphate transporter
FGL66_RS01415	COG1388	LysM domain
FGL66_RS01415	COG3942	CHAP domain
FGL66_RS01430	COG0217	transcriptional regulatory protein
FGL66_RS01450	COG0583	DNA-binding transcription factor activity
FGL66_RS01455	COG2814	Major facilitator Superfamily
FGL66_RS01460	COG2839	Protein conserved in bacteria
FGL66_RS01490	COG1671	Belongs to the UPF0178 family
FGL66_RS01500	COG1968	undecaprenyl-diphosphatase activity
FGL66_RS01510	COG0523	cobalamin synthesis protein
FGL66_RS01515	COG4989	oxidoreductase activity
FGL66_RS01525	COG0039	L-malate dehydrogenase activity
FGL66_RS01540	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FGL66_RS01545	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FGL66_RS01550	COG1349	DNA-binding transcription factor activity
FGL66_RS01555	COG1105	Belongs to the carbohydrate kinase PfkB family
FGL66_RS01560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FGL66_RS01560	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FGL66_RS01560	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FGL66_RS01565	COG1253	flavin adenine dinucleotide binding
FGL66_RS01580	COG0463	Glycosyl transferase, family 2
FGL66_RS01610	COG0602	queuosine metabolic process
FGL66_RS01615	COG0720	synthase
FGL66_RS01625	COG0512	Glutamine amidotransferase of anthranilate synthase
FGL66_RS01625	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FGL66_RS01655	COG1368	sulfuric ester hydrolase activity
FGL66_RS01665	COG0488	(ABC) transporter
FGL66_RS01670	COG0514	ATP-dependent DNA helicase (RecQ)
FGL66_RS01675	COG0517	IMP dehydrogenase activity
FGL66_RS01675	COG1125	glycine betaine transport
FGL66_RS01680	COG1174	glycine betaine transport
FGL66_RS01685	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FGL66_RS01690	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
FGL66_RS01695	COG3104	oligopeptide transport
FGL66_RS01700	COG3104	oligopeptide transport
FGL66_RS01705	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FGL66_RS01720	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FGL66_RS01725	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FGL66_RS01755	COG1929	Belongs to the glycerate kinase type-1 family
FGL66_RS01760	COG2195	Cleaves the N-terminal amino acid of tripeptides
FGL66_RS01780	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FGL66_RS01785	COG1739	Uncharacterized protein family UPF0029
FGL66_RS01795	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
FGL66_RS01805	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FGL66_RS01810	COG0653	protein targeting
FGL66_RS01820	COG3942	CHAP domain
FGL66_RS01840	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FGL66_RS01850	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
FGL66_RS01855	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FGL66_RS01870	COG0492	ferredoxin-NADP+ reductase activity
FGL66_RS01875	COG1660	Displays ATPase and GTPase activities
FGL66_RS01880	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FGL66_RS01885	COG1481	regulation of sporulation
FGL66_RS01890	COG3759	membrane
FGL66_RS01895	COG1278	Cold shock
FGL66_RS01910	COG1247	-acetyltransferase
FGL66_RS01915	COG1090	epimerase
FGL66_RS01935	COG0126	phosphoglycerate kinase activity
FGL66_RS01940	COG0149	triose-phosphate isomerase activity
FGL66_RS01945	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FGL66_RS01965	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FGL66_RS01970	COG1647	Serine aminopeptidase, S33
FGL66_RS01975	COG0557	exoribonuclease II activity
FGL66_RS02005	COG1764	response to oxidative stress
FGL66_RS02015	COG0710	3-dehydroquinate dehydratase activity
FGL66_RS02025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FGL66_RS02030	COG1393	Belongs to the ArsC family
FGL66_RS02045	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FGL66_RS02050	COG2011	ABC-type metal ion transport system permease component
FGL66_RS02055	COG1464	Belongs to the NlpA lipoprotein family
FGL66_RS02060	COG1464	Belongs to the NlpA lipoprotein family
FGL66_RS02085	COG0396	ATPase activity
FGL66_RS02090	COG0719	Fe-S assembly protein
FGL66_RS02100	COG0822	iron-sulfur transferase activity
FGL66_RS02105	COG0719	Fe-S assembly protein
FGL66_RS02120	COG4536	flavin adenine dinucleotide binding
FGL66_RS02125	COG1801	Protein of unknown function DUF72
FGL66_RS02130	COG0730	response to heat
FGL66_RS02135	COG0737	Belongs to the 5'-nucleotidase family
FGL66_RS02140	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FGL66_RS02145	COG4470	Protein conserved in bacteria
FGL66_RS02155	COG2445	Protein of unknown function DUF86
FGL66_RS02160	COG0647	UMP catabolic process
FGL66_RS02165	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FGL66_RS02170	COG4837	Protein of unknown function (DUF1462)
FGL66_RS02175	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FGL66_RS02180	COG1252	NADH dehydrogenase
FGL66_RS02185	COG4844	belongs to the
FGL66_RS02190	COG0316	Belongs to the HesB IscA family
FGL66_RS02195	COG1252	NADH dehydrogenase
FGL66_RS02200	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FGL66_RS02205	COG2056	Na+-H+ antiporter family
FGL66_RS02210	COG2050	protein possibly involved in aromatic compounds catabolism
FGL66_RS02225	COG1320	monovalent cation:proton antiporter activity
FGL66_RS02230	COG2212	antiporter activity
FGL66_RS02240	COG0651	ATP synthesis coupled electron transport
FGL66_RS02245	COG1006	Multisubunit Na H antiporter MnhC subunit
FGL66_RS02250	COG2111	Na H antiporter
FGL66_RS02255	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FGL66_RS02255	COG2111	Na H antiporter
FGL66_RS02265	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FGL66_RS02275	COG1098	S1 RNA binding domain
FGL66_RS02280	COG1012	belongs to the aldehyde dehydrogenase family
FGL66_RS02295	COG0165	Argininosuccinate lyase
FGL66_RS02300	COG0137	argininosuccinate synthase activity
FGL66_RS02315	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
FGL66_RS02320	COG1074	ATP-dependent DNA helicase activity
FGL66_RS02325	COG0179	Fumarylacetoacetate (FAA) hydrolase
FGL66_RS02335	COG0446	pyridine nucleotide-disulphide oxidoreductase
FGL66_RS02340	COG0561	phosphatase activity
FGL66_RS02345	COG2151	metal-sulfur cluster biosynthetic enzyme
FGL66_RS02355	COG0542	response to heat
FGL66_RS02380	COG0601	transmembrane transport
FGL66_RS02385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FGL66_RS02390	COG0444	Belongs to the ABC transporter superfamily
FGL66_RS02395	COG4608	Belongs to the ABC transporter superfamily
FGL66_RS02400	COG4166	transmembrane transport
FGL66_RS02405	COG0180	Tryptophanyl-tRNA synthetase
FGL66_RS02410	COG1393	Belongs to the ArsC family
FGL66_RS02415	COG4862	establishment of competence for transformation
FGL66_RS02425	COG1164	Oligoendopeptidase f
FGL66_RS02435	COG2346	COG2346, Truncated hemoglobins
FGL66_RS02440	COG4116	CYTH
FGL66_RS02450	COG2357	RelA SpoT domain protein
FGL66_RS02455	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FGL66_RS02460	COG0564	pseudouridine synthase activity
FGL66_RS02465	COG2239	Acts as a magnesium transporter
FGL66_RS02470	COG0475	glutathione-regulated potassium exporter activity
FGL66_RS02470	COG0569	domain protein
FGL66_RS02475	COG3583	domain protein
FGL66_RS02485	COG0628	permease
FGL66_RS02490	COG1115	amino acid carrier protein
FGL66_RS02500	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FGL66_RS02505	COG2814	Major facilitator Superfamily
FGL66_RS02510	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FGL66_RS02515	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FGL66_RS02525	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FGL66_RS02530	COG0861	Integral membrane protein TerC family
FGL66_RS02555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FGL66_RS02560	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FGL66_RS02570	COG0737	Belongs to the 5'-nucleotidase family
FGL66_RS02625	COG4873	Protein conserved in bacteria
FGL66_RS02640	COG4619	ABC transporter
FGL66_RS02645	COG0390	transport system, permease component
FGL66_RS02650	COG1575	Belongs to the MenA family. Type 1 subfamily
FGL66_RS02655	COG1169	isochorismate synthase
FGL66_RS02660	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FGL66_RS02670	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FGL66_RS02675	COG0436	Aminotransferase
FGL66_RS02680	COG3594	Acyltransferase
FGL66_RS02710	COG1316	TRANSCRIPTIONal
FGL66_RS02715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FGL66_RS02725	COG1017	nitric oxide dioxygenase activity
FGL66_RS02725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FGL66_RS02735	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FGL66_RS02750	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FGL66_RS02755	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FGL66_RS02760	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FGL66_RS02765	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FGL66_RS02770	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FGL66_RS02775	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FGL66_RS02785	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FGL66_RS02790	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FGL66_RS02795	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FGL66_RS02805	COG0138	bifunctional purine biosynthesis protein purh
FGL66_RS02810	COG0151	Belongs to the GarS family
FGL66_RS02820	COG1122	ATPase activity
FGL66_RS02835	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FGL66_RS02845	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FGL66_RS02865	COG0569	domain protein
FGL66_RS02870	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FGL66_RS02910	COG4476	Belongs to the UPF0223 family
FGL66_RS02920	COG3842	ATPase activity
FGL66_RS02925	COG1176	ABC-type spermidine putrescine transport system, permease component I
FGL66_RS02930	COG1177	transmembrane transport
FGL66_RS02935	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
FGL66_RS02950	COG4493	Belongs to the UPF0637 family
FGL66_RS02955	COG0483	inositol monophosphate 1-phosphatase activity
FGL66_RS02970	COG1902	pentaerythritol trinitrate reductase activity
FGL66_RS02975	COG4896	Protein conserved in bacteria
FGL66_RS02980	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FGL66_RS02985	COG4838	Belongs to the UPF0358 family
FGL66_RS02990	COG0772	Belongs to the SEDS family
FGL66_RS03000	COG1612	heme a metabolic process
FGL66_RS03005	COG0109	protoheme IX farnesyltransferase activity
FGL66_RS03020	COG0738	Major facilitator superfamily
FGL66_RS03025	COG0673	inositol 2-dehydrogenase activity
FGL66_RS03030	COG0561	phosphatase activity
FGL66_RS03035	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FGL66_RS03040	COG1609	Transcriptional regulator
FGL66_RS03075	COG3679	Belongs to the UPF0342 family
FGL66_RS03085	COG4471	UPF0298 protein
FGL66_RS03095	COG0742	ribosomal rna small subunit methyltransferase
FGL66_RS03100	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FGL66_RS03115	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FGL66_RS03120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FGL66_RS03125	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FGL66_RS03130	COG0072	phenylalanine-tRNA ligase activity
FGL66_RS03130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FGL66_RS03135	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FGL66_RS03140	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
FGL66_RS03150	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FGL66_RS03150	COG1796	DNA polymerase
FGL66_RS03160	COG3118	belongs to the thioredoxin family
FGL66_RS03165	COG0322	excinuclease ABC activity
FGL66_RS03170	COG2009	succinate dehydrogenase
FGL66_RS03175	COG1053	succinate dehydrogenase
FGL66_RS03180	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FGL66_RS03210	COG2814	Major facilitator Superfamily
FGL66_RS03265	COG0454	-acetyltransferase
FGL66_RS03270	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
FGL66_RS03275	COG2001	Belongs to the MraZ family
FGL66_RS03280	COG0275	rRNA processing
FGL66_RS03285	COG4839	cell division protein FtsL
FGL66_RS03300	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FGL66_RS03310	COG0849	cell division
FGL66_RS03315	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FGL66_RS03325	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FGL66_RS03330	COG1799	cell septum assembly
FGL66_RS03335	COG0762	integral membrane protein
FGL66_RS03345	COG3599	regulation of cell shape
FGL66_RS03350	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FGL66_RS03355	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FGL66_RS03360	COG0564	pseudouridine synthase activity
FGL66_RS03365	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FGL66_RS03385	COG0505	Belongs to the CarA family
FGL66_RS03390	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FGL66_RS03400	COG0167	dihydroorotate dehydrogenase activity
FGL66_RS03405	COG0284	orotidine-5'-phosphate decarboxylase activity
FGL66_RS03410	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FGL66_RS03420	COG1293	RNA-binding protein homologous to eukaryotic snRNP
FGL66_RS03430	COG1758	RNA polymerase activity
FGL66_RS03435	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FGL66_RS03440	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FGL66_RS03500	COG0242	peptide deformylase activity
FGL66_RS03505	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FGL66_RS03510	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FGL66_RS03510	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FGL66_RS03515	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FGL66_RS03520	COG0631	protein serine/threonine phosphatase activity
FGL66_RS03530	COG1162	GTPase activity
FGL66_RS03535	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FGL66_RS03550	COG1302	Protein conserved in bacteria
FGL66_RS03560	COG1760	l-serine dehydratase
FGL66_RS03565	COG1760	l-serine dehydratase
FGL66_RS03570	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FGL66_RS03580	COG0416	fatty acid biosynthetic process
FGL66_RS03595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FGL66_RS03600	COG0571	ribonuclease III activity
FGL66_RS03605	COG1196	nuclear chromosome segregation
FGL66_RS03610	COG0552	protein localization to endoplasmic reticulum
FGL66_RS03615	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
FGL66_RS03620	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FGL66_RS03625	COG0228	four-way junction DNA binding
FGL66_RS03635	COG0336	Belongs to the RNA methyltransferase TrmD family
FGL66_RS03665	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FGL66_RS03675	COG0045	succinate-CoA ligase (ADP-forming) activity
FGL66_RS03685	COG0758	DNA mediated transformation
FGL66_RS03690	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FGL66_RS03695	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
FGL66_RS03700	COG4974	Belongs to the 'phage' integrase family
FGL66_RS03710	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FGL66_RS03720	COG0052	Belongs to the universal ribosomal protein uS2 family
FGL66_RS03725	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FGL66_RS03730	COG0528	UMP kinase activity
FGL66_RS03735	COG0233	cytoplasmic translational termination
FGL66_RS03745	COG4589	Belongs to the CDS family
FGL66_RS03750	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FGL66_RS03760	COG0442	prolyl-tRNA aminoacylation
FGL66_RS03765	COG2176	DNA-directed DNA polymerase activity
FGL66_RS03770	COG0779	Required for maturation of 30S ribosomal subunits
FGL66_RS03775	COG0195	Participates in both transcription termination and antitermination
FGL66_RS03780	COG2740	Nucleic-acid-binding protein implicated in transcription termination
FGL66_RS03785	COG1358	cellular component organization or biogenesis
FGL66_RS03790	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FGL66_RS03795	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FGL66_RS03800	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FGL66_RS03805	COG0196	riboflavin kinase activity
FGL66_RS03815	COG1185	polyribonucleotide nucleotidyltransferase activity
FGL66_RS03820	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FGL66_RS03830	COG2188	Transcriptional regulator
FGL66_RS03835	COG0612	Peptidase, M16
FGL66_RS03840	COG0612	Peptidase, M16
FGL66_RS03865	COG1546	Belongs to the CinA family
FGL66_RS03865	COG1058	Belongs to the CinA family
FGL66_RS03870	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FGL66_RS03875	COG1418	mRNA catabolic process
FGL66_RS03895	COG1692	metallophosphoesterase
FGL66_RS03900	COG0674	pyruvate-flavodoxin oxidoreductase activity
FGL66_RS03900	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FGL66_RS03905	COG1013	pyruvate-flavodoxin oxidoreductase activity
FGL66_RS03910	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FGL66_RS03915	COG4550	Control of competence regulator ComK, YlbF/YmcA
FGL66_RS03930	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FGL66_RS03935	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
FGL66_RS03940	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FGL66_RS03945	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FGL66_RS03950	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FGL66_RS03960	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FGL66_RS03965	COG1923	regulation of RNA biosynthetic process
FGL66_RS03970	COG0386	Belongs to the glutathione peroxidase family
FGL66_RS03980	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
FGL66_RS03995	COG0789	Transcriptional regulator
FGL66_RS04055	COG0589	response to stress
FGL66_RS04065	COG0006	proline dipeptidase activity
FGL66_RS04070	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FGL66_RS04080	COG4109	DRTGG domain
FGL66_RS04085	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FGL66_RS04090	COG0587	DNA-directed DNA polymerase activity
FGL66_RS04095	COG0281	malic enzyme
FGL66_RS04100	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FGL66_RS04105	COG0825	malonyl-CoA metabolic process
FGL66_RS04110	COG0205	6-phosphofructokinase activity
FGL66_RS04115	COG0469	pyruvate kinase activity
FGL66_RS04120	COG0372	Belongs to the citrate synthase family
FGL66_RS04145	COG0745	RESPONSE REGULATOR receiver
FGL66_RS04150	COG5002	protein histidine kinase activity
FGL66_RS04155	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FGL66_RS04155	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FGL66_RS04160	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FGL66_RS04165	COG0237	dephospho-CoA kinase activity
FGL66_RS04170	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FGL66_RS04175	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FGL66_RS04180	COG3611	Membrane attachment protein
FGL66_RS04185	COG1484	DNA-dependent DNA replication
FGL66_RS04190	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FGL66_RS04195	COG0833	amino acid
FGL66_RS04200	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FGL66_RS04205	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FGL66_RS04210	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FGL66_RS04225	COG0544	peptidyl-prolyl cis-trans isomerase activity
FGL66_RS04230	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FGL66_RS04240	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FGL66_RS04245	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FGL66_RS04250	COG0181	hydroxymethylbilane synthase activity
FGL66_RS04265	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FGL66_RS04275	COG2818	Glycosylase
FGL66_RS04280	COG0525	valine-tRNA ligase activity
FGL66_RS04285	COG0285	dihydrofolate synthase activity
FGL66_RS04295	COG2003	Belongs to the UPF0758 family
FGL66_RS04305	COG1792	Involved in formation and maintenance of cell shape
FGL66_RS04315	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FGL66_RS04320	COG2868	ribosomal protein
FGL66_RS04325	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FGL66_RS04340	COG0632	four-way junction helicase activity
FGL66_RS04360	COG1862	Preprotein translocase
FGL66_RS04365	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FGL66_RS04365	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FGL66_RS04370	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FGL66_RS04370	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FGL66_RS04375	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FGL66_RS04385	COG1490	D-aminoacyl-tRNA deacylase activity
FGL66_RS04390	COG0860	N-Acetylmuramoyl-L-alanine amidase
FGL66_RS04410	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FGL66_RS04420	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FGL66_RS04425	COG1959	2 iron, 2 sulfur cluster binding
FGL66_RS04440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FGL66_RS04445	COG1104	cysteine desulfurase activity
FGL66_RS04450	COG0482	sulfurtransferase activity
FGL66_RS04460	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FGL66_RS04470	COG4472	Bacterial protein of unknown function (DUF965)
FGL66_RS04475	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FGL66_RS04480	COG3906	Belongs to the UPF0473 family
FGL66_RS04485	COG4122	O-methyltransferase activity
FGL66_RS04500	COG0572	uridine kinase
FGL66_RS04510	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FGL66_RS04515	COG1984	allophanate hydrolase subunit 2
FGL66_RS04520	COG0511	ligase activity, forming carbon-carbon bonds
FGL66_RS04525	COG0439	Biotin carboxylase
FGL66_RS04530	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FGL66_RS04535	COG1914	H( )-stimulated, divalent metal cation uptake system
FGL66_RS04540	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FGL66_RS04545	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
FGL66_RS04550	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FGL66_RS04555	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FGL66_RS04560	COG1534	Rna-binding protein
FGL66_RS04570	COG1713	HD superfamily hydrolase involved in NAD metabolism
FGL66_RS04575	COG0799	negative regulation of ribosome biogenesis
FGL66_RS04580	COG2226	methyltransferase
FGL66_RS04585	COG1555	photosystem II stabilization
FGL66_RS04585	COG1596	polysaccharide export
FGL66_RS04590	COG2131	deaminase
FGL66_RS04595	COG2333	competence protein COMEC
FGL66_RS04595	COG0658	competence protein
FGL66_RS04600	COG1466	dna polymerase III delta subunit
FGL66_RS04605	COG0268	Binds directly to 16S ribosomal RNA
FGL66_RS04615	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FGL66_RS04620	COG1420	regulation of RNA biosynthetic process
FGL66_RS04630	COG0443	Heat shock 70 kDa protein
FGL66_RS04635	COG0484	heat shock protein binding
FGL66_RS04640	COG2264	protein methyltransferase activity
FGL66_RS04645	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FGL66_RS04650	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FGL66_RS04665	COG4864	UPF0365 protein
FGL66_RS04675	COG1702	phosphate starvation-inducible protein PhoH
FGL66_RS04685	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FGL66_RS04690	COG0295	cytidine deaminase activity
FGL66_RS04695	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FGL66_RS04700	COG1381	Involved in DNA repair and RecF pathway recombination
FGL66_RS04705	COG0423	glycine-tRNA ligase activity
FGL66_RS04710	COG0517	IMP dehydrogenase activity
FGL66_RS04715	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FGL66_RS04720	COG0358	DNA primase activity
FGL66_RS04725	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FGL66_RS04730	COG2384	SAM-dependent methyltransferase
FGL66_RS04740	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FGL66_RS04745	COG0513	Belongs to the DEAD box helicase family
FGL66_RS04750	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FGL66_RS04755	COG1121	(ABC) transporter
FGL66_RS04760	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FGL66_RS04770	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FGL66_RS04790	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FGL66_RS04795	COG0705	Rhomboid family
FGL66_RS04800	COG4483	Protein conserved in bacteria
FGL66_RS04805	COG1940	carbohydrate kinase activity
FGL66_RS04810	COG0011	TIGRFAM Protein of
FGL66_RS04815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FGL66_RS04820	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FGL66_RS04825	COG1459	type II secretion system
FGL66_RS04845	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FGL66_RS04850	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FGL66_RS04860	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FGL66_RS04865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FGL66_RS04870	COG0095	Lipoate-protein ligase
FGL66_RS04885	COG0006	proline dipeptidase activity
FGL66_RS04890	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FGL66_RS04895	COG0511	ligase activity, forming carbon-carbon bonds
FGL66_RS04900	COG0439	Biotin carboxylase
FGL66_RS04905	COG1302	Protein conserved in bacteria
FGL66_RS04915	COG1570	exodeoxyribonuclease VII activity
FGL66_RS04930	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FGL66_RS04940	COG0497	DNA recombination
FGL66_RS04945	COG0280	phosphate acetyltransferase
FGL66_RS04950	COG3426	butyrate kinase activity
FGL66_RS04955	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FGL66_RS04960	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FGL66_RS04965	COG0022	dehydrogenase e1 component
FGL66_RS04970	COG0508	dehydrogenase complex catalyzes the overall conversion of
FGL66_RS04980	COG4129	membrane
FGL66_RS04990	COG2195	Cleaves the N-terminal amino acid of tripeptides
FGL66_RS05005	COG2207	Transcriptional regulator
FGL66_RS05010	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FGL66_RS05015	COG1234	tRNA 3'-trailer cleavage
FGL66_RS05020	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FGL66_RS05030	COG0667	Aldo Keto reductase
FGL66_RS05035	COG0494	nUDIX hydrolase
FGL66_RS05040	COG0735	belongs to the Fur family
FGL66_RS05045	COG4974	Belongs to the 'phage' integrase family
FGL66_RS05055	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FGL66_RS05060	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FGL66_RS05065	COG1187	pseudouridine synthase activity
FGL66_RS05070	COG0745	RESPONSE REGULATOR receiver
FGL66_RS05075	COG5002	protein histidine kinase activity
FGL66_RS05085	COG1141	Ferredoxin
FGL66_RS05095	COG0514	ATP-dependent DNA helicase (RecQ)
FGL66_RS05105	COG0492	ferredoxin-NADP+ reductase activity
FGL66_RS05110	COG0252	asparaginase activity
FGL66_RS05115	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FGL66_RS05120	COG0539	negative regulation of cytoplasmic translation
FGL66_RS05130	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FGL66_RS05145	COG2226	methyltransferase
FGL66_RS05150	COG0142	geranyltranstransferase activity
FGL66_RS05155	COG0105	UTP biosynthetic process
FGL66_RS05160	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FGL66_RS05165	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FGL66_RS05175	COG0457	Tetratricopeptide repeat
FGL66_RS05180	COG5582	Belongs to the UPF0302 family
FGL66_RS05185	COG4347	Protein of unknown function (DUF1405)
FGL66_RS05210	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FGL66_RS05215	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FGL66_RS05220	COG1695	Transcriptional regulator
FGL66_RS05230	COG1694	Mazg nucleotide pyrophosphohydrolase
FGL66_RS05235	COG0438	transferase activity, transferring glycosyl groups
FGL66_RS05240	COG0617	tRNA 3'-terminal CCA addition
FGL66_RS05250	COG1199	ATP-dependent helicase activity
FGL66_RS05250	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FGL66_RS05255	COG0017	Asparaginyl-tRNA synthetase
FGL66_RS05260	COG3935	DnaD domain protein
FGL66_RS05265	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FGL66_RS05275	COG4499	WXG100 protein secretion system (Wss), protein YukC
FGL66_RS05275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FGL66_RS05280	COG3331	DNA recombination
FGL66_RS05290	COG4474	Belongs to the UPF0398 family
FGL66_RS05295	COG3599	regulation of cell shape
FGL66_RS05305	COG0116	Belongs to the methyltransferase superfamily
FGL66_RS05310	COG2962	Rard protein
FGL66_RS05320	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
FGL66_RS05325	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FGL66_RS05335	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FGL66_RS05345	COG1413	lyase activity
FGL66_RS05375	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FGL66_RS05385	COG4479	Belongs to the UPF0346 family
FGL66_RS05390	COG0793	Belongs to the peptidase S41A family
FGL66_RS05405	COG0671	phosphoesterase, PA-phosphatase related
FGL66_RS05410	COG0745	RESPONSE REGULATOR receiver
FGL66_RS05415	COG5002	protein histidine kinase activity
FGL66_RS05420	COG0567	Dehydrogenase, E1 component
FGL66_RS05440	COG0714	Associated with various cellular activities
FGL66_RS05445	COG4548	von Willebrand factor, type A
FGL66_RS05450	COG1114	Component of the transport system for branched-chain amino acids
FGL66_RS05455	COG2249	NAD(P)H dehydrogenase (quinone) activity
FGL66_RS05460	COG3853	Toxic anion resistance protein (TelA)
FGL66_RS05500	COG1473	amidohydrolase
FGL66_RS05510	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FGL66_RS05515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FGL66_RS05520	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FGL66_RS05525	COG0488	(ABC) transporter
FGL66_RS05530	COG2996	Protein conserved in bacteria
FGL66_RS05545	COG2348	transferase activity, transferring amino-acyl groups
FGL66_RS05550	COG2348	transferase activity, transferring amino-acyl groups
FGL66_RS05555	COG0287	Prephenate dehydrogenase
FGL66_RS05585	COG0628	permease
FGL66_RS05595	COG3711	transcriptional antiterminator
FGL66_RS05600	COG1115	amino acid carrier protein
FGL66_RS05605	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FGL66_RS05615	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FGL66_RS05620	COG4841	protein insertion into membrane
FGL66_RS05625	COG0824	Thioesterase
FGL66_RS05635	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FGL66_RS05640	COG1970	mechanosensitive ion channel activity
FGL66_RS05650	COG0420	3'-5' exonuclease activity
FGL66_RS05655	COG4846	Membrane protein involved in cytochrome C biogenesis
FGL66_RS05670	COG4224	UPF0291 protein
FGL66_RS05680	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FGL66_RS05685	COG0516	GMP reductase activity
FGL66_RS05690	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FGL66_RS05700	COG0753	catalase activity
FGL66_RS05705	COG0833	amino acid
FGL66_RS05715	COG0561	phosphatase activity
FGL66_RS05720	COG0083	homoserine kinase activity
FGL66_RS05725	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FGL66_RS05730	COG0460	homoserine dehydrogenase
FGL66_RS05735	COG0527	aspartate kinase activity
FGL66_RS05745	COG1525	nuclease
FGL66_RS05760	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FGL66_RS05765	COG0827	DNA restriction-modification system
FGL66_RS05770	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FGL66_RS05775	COG1714	RDD family
FGL66_RS05780	COG0616	signal peptide processing
FGL66_RS05790	COG0301	tRNA thio-modification
FGL66_RS05795	COG1104	cysteine desulfurase activity
FGL66_RS05800	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
FGL66_RS05805	COG1956	GAF domain-containing protein
FGL66_RS05820	COG0584	glycerophosphoryl diester phosphodiesterase
FGL66_RS05825	COG1764	response to oxidative stress
FGL66_RS05830	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FGL66_RS05835	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FGL66_RS05845	COG0204	Acyl-transferase
FGL66_RS05850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FGL66_RS05860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FGL66_RS05860	COG4499	WXG100 protein secretion system (Wss), protein YukC
FGL66_RS05870	COG1609	Transcriptional regulator
FGL66_RS05875	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FGL66_RS05875	COG1605	Chorismate mutase
FGL66_RS05890	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
FGL66_RS05900	COG1674	ftsk spoiiie
FGL66_RS05905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FGL66_RS05915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FGL66_RS05920	COG1363	Peptidase, m42
FGL66_RS05930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FGL66_RS05935	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FGL66_RS05940	COG0510	thiamine kinase activity
FGL66_RS05945	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FGL66_RS05950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FGL66_RS05960	COG1187	pseudouridine synthase activity
FGL66_RS05965	COG2244	polysaccharide biosynthetic process
FGL66_RS05970	COG2081	HI0933 family
FGL66_RS05975	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FGL66_RS05980	COG0495	leucyl-tRNA aminoacylation
FGL66_RS05985	COG2814	Major facilitator Superfamily
FGL66_RS05990	COG1242	4 iron, 4 sulfur cluster binding
FGL66_RS05995	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
FGL66_RS06005	COG0039	L-malate dehydrogenase activity
FGL66_RS06010	COG2267	carboxylic ester hydrolase activity
FGL66_RS06020	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FGL66_RS06025	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FGL66_RS06025	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FGL66_RS06035	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FGL66_RS06035	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FGL66_RS06045	COG5632	N-Acetylmuramoyl-L-alanine amidase
FGL66_RS06045	COG4193	domain, Protein
FGL66_RS06045	COG3266	domain, Protein
FGL66_RS06070	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FGL66_RS06080	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FGL66_RS06085	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FGL66_RS06095	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FGL66_RS06100	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FGL66_RS06105	COG1506	peptidase
FGL66_RS06110	COG0494	nUDIX hydrolase
FGL66_RS06115	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FGL66_RS06130	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FGL66_RS06165	COG0582	viral genome integration into host DNA
FGL66_RS06225	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FGL66_RS06230	COG2329	Antibiotic biosynthesis monooxygenase
FGL66_RS06235	COG4473	ABC transporter
FGL66_RS06240	COG1131	(ABC) transporter
FGL66_RS06245	COG0537	adenosine 5'-monophosphoramidase activity
FGL66_RS06265	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FGL66_RS06270	COG3481	metal-dependent phosphohydrolase, HD sub domain
FGL66_RS06280	COG0420	3'-5' exonuclease activity
FGL66_RS06285	COG3679	Belongs to the UPF0342 family
FGL66_RS06290	COG4399	Belongs to the UPF0754 family
FGL66_RS06305	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FGL66_RS06310	COG2197	response regulator
FGL66_RS06315	COG4585	Histidine kinase
FGL66_RS06315	COG2203	Gaf domain
FGL66_RS06320	COG0564	pseudouridine synthase activity
FGL66_RS06325	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FGL66_RS06330	COG0248	Ppx GppA phosphatase
FGL66_RS06335	COG0114	fumarate hydratase activity
FGL66_RS06350	COG0363	glucosamine-6-phosphate deaminase activity
FGL66_RS06355	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FGL66_RS06365	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FGL66_RS06370	COG1126	abc transporter atp-binding protein
FGL66_RS06375	COG0765	amino acid transport
FGL66_RS06525	COG0735	belongs to the Fur family
FGL66_RS06535	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FGL66_RS06540	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FGL66_RS06555	COG4129	membrane
FGL66_RS06565	COG3557	Belongs to the UPF0374 family
FGL66_RS06570	COG1194	a g-specific adenine glycosylase
FGL66_RS06575	COG1988	membrane-bound metal-dependent
FGL66_RS06585	COG1388	LysM domain
FGL66_RS06585	COG1134	teichoic acid transport
FGL66_RS06595	COG2137	regulation of response to DNA damage stimulus
FGL66_RS06600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FGL66_RS06605	COG2348	transferase activity, transferring amino-acyl groups
FGL66_RS06610	COG0693	protein deglycase activity
FGL66_RS06620	COG0535	radical SAM domain protein
FGL66_RS06625	COG1607	acyl-coa hydrolase
FGL66_RS06630	COG2309	aminopeptidase activity
FGL66_RS06635	COG4840	Belongs to the UPF0435 family
FGL66_RS06640	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FGL66_RS06650	COG1295	ribonuclease BN
FGL66_RS06655	COG0288	reversible hydration of carbon dioxide
FGL66_RS06660	COG2197	response regulator
FGL66_RS06685	COG4129	membrane
FGL66_RS06700	COG1136	(ABC) transporter
FGL66_RS06700	COG0577	efflux transmembrane transporter activity
FGL66_RS06715	COG1528	Iron-storage protein
FGL66_RS06725	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FGL66_RS06735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FGL66_RS06755	COG0542	response to heat
FGL66_RS06760	COG1396	sequence-specific DNA binding
FGL66_RS06765	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FGL66_RS06770	COG1597	lipid kinase activity
FGL66_RS06775	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FGL66_RS06785	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FGL66_RS06790	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FGL66_RS06795	COG2197	response regulator
FGL66_RS06805	COG0842	Transport permease protein
FGL66_RS06810	COG1131	(ABC) transporter
FGL66_RS06815	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FGL66_RS06820	COG4851	CamS sex pheromone cAM373 precursor
FGL66_RS06825	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FGL66_RS06830	COG0210	DNA helicase
FGL66_RS06840	COG4496	protein, YerC YecD
FGL66_RS06855	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
FGL66_RS06860	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FGL66_RS06865	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FGL66_RS06875	COG0077	Prephenate dehydratase
FGL66_RS06890	COG1335	isochorismatase
FGL66_RS06895	COG1227	inorganic diphosphatase activity
FGL66_RS06905	COG1012	belongs to the aldehyde dehydrogenase family
FGL66_RS06910	COG2706	6-phosphogluconolactonase activity
FGL66_RS06940	COG2610	gluconate transmembrane transporter activity
FGL66_RS06945	COG1070	Carbohydrate kinase
FGL66_RS06960	COG1131	(ABC) transporter
FGL66_RS06980	COG1131	(ABC) transporter
FGL66_RS06985	COG1725	Transcriptional regulator
FGL66_RS07000	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FGL66_RS07015	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FGL66_RS07040	COG4512	PFAM Accessory gene regulator B
FGL66_RS07065	COG1621	beta-fructofuranosidase activity
FGL66_RS07070	COG1609	Transcriptional regulator
FGL66_RS07075	COG0425	Belongs to the sulfur carrier protein TusA family
FGL66_RS07080	COG2391	methyltransferase activity
FGL66_RS07090	COG0488	(ABC) transporter
FGL66_RS07095	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FGL66_RS07100	COG0456	acetyltransferase
FGL66_RS07105	COG1214	PFAM Peptidase M22, glycoprotease
FGL66_RS07110	COG0802	atpase or kinase
FGL66_RS07115	COG0129	dihydroxy-acid dehydratase activity
FGL66_RS07120	COG0028	Belongs to the TPP enzyme family
FGL66_RS07135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FGL66_RS07140	COG0473	3-isopropylmalate dehydrogenase activity
FGL66_RS07145	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FGL66_RS07150	COG0066	3-isopropylmalate dehydratase activity
FGL66_RS07185	COG2183	response to ionizing radiation
FGL66_RS07190	COG1191	sigma factor activity
FGL66_RS07205	COG2208	phosphoserine phosphatase activity
FGL66_RS07210	COG2337	Toxic component of a toxin-antitoxin (TA) module
FGL66_RS07245	COG0513	Belongs to the DEAD box helicase family
FGL66_RS07250	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FGL66_RS07255	COG1181	Belongs to the D-alanine--D-alanine ligase family
FGL66_RS07260	COG0772	Belongs to the SEDS family
FGL66_RS07265	COG2217	Heavy metal translocating P-type atpase
FGL66_RS07270	COG2608	mercury ion transmembrane transporter activity
FGL66_RS07280	COG1937	Protein conserved in bacteria
FGL66_RS07285	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FGL66_RS07290	COG1418	mRNA catabolic process
FGL66_RS07295	COG0706	membrane insertase activity
FGL66_RS07300	COG0352	thiamine-phosphate diphosphorylase activity
FGL66_RS07315	COG0629	single-stranded DNA binding
FGL66_RS07325	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FGL66_RS07335	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FGL66_RS07340	COG4836	Membrane
FGL66_RS07355	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FGL66_RS07360	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FGL66_RS07365	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FGL66_RS07370	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FGL66_RS07375	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FGL66_RS07380	COG0356	it plays a direct role in the translocation of protons across the membrane
FGL66_RS07390	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FGL66_RS07395	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FGL66_RS07400	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FGL66_RS07405	COG4475	Protein of unknown function (DUF436)
FGL66_RS07410	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FGL66_RS07415	COG0009	L-threonylcarbamoyladenylate synthase
FGL66_RS07420	COG2890	protein-(glutamine-N5) methyltransferase activity
FGL66_RS07425	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FGL66_RS07435	COG0254	rRNA binding
FGL66_RS07440	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FGL66_RS07445	COG1012	belongs to the aldehyde dehydrogenase family
FGL66_RS07450	COG1733	regulation of RNA biosynthetic process
FGL66_RS07455	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FGL66_RS07460	COG0191	fructose-bisphosphate aldolase activity
FGL66_RS07465	COG4821	SIS domain
FGL66_RS07475	COG2271	Major facilitator Superfamily
FGL66_RS07490	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FGL66_RS07495	COG5146	pantothenate kinase activity
FGL66_RS07515	COG1854	S-ribosylhomocysteine lyase activity
FGL66_RS07530	COG0813	purine-nucleoside phosphorylase activity
FGL66_RS07535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FGL66_RS07560	COG2186	Transcriptional regulator
FGL66_RS07570	COG0561	phosphatase activity
FGL66_RS07575	COG1119	ATPase activity
FGL66_RS07595	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
FGL66_RS07650	COG0489	protein tyrosine kinase activity
FGL66_RS07655	COG2814	Major facilitator Superfamily
FGL66_RS07670	COG1272	protein, Hemolysin III
FGL66_RS07675	COG4284	Utp--glucose-1-phosphate uridylyltransferase
FGL66_RS07680	COG1988	membrane-bound metal-dependent
FGL66_RS07695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FGL66_RS07700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FGL66_RS07705	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FGL66_RS07710	COG3457	Alanine racemase
FGL66_RS07715	COG4264	IucA IucC family
FGL66_RS07720	COG2814	Major facilitator Superfamily
FGL66_RS07725	COG4264	IucA IucC family
FGL66_RS07730	COG2814	Major facilitator Superfamily
FGL66_RS07735	COG1302	Protein conserved in bacteria
FGL66_RS07750	COG2723	6-phospho-beta-galactosidase activity
FGL66_RS07760	COG2188	Transcriptional regulator
FGL66_RS07780	COG5002	protein histidine kinase activity
FGL66_RS07785	COG1126	abc transporter atp-binding protein
FGL66_RS07790	COG0765	amino acid transport
FGL66_RS07795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FGL66_RS07810	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FGL66_RS07820	COG0433	COG0433 Predicted ATPase
FGL66_RS07850	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FGL66_RS07860	COG0101	tRNA pseudouridine synthase activity
FGL66_RS07870	COG1122	ATPase activity
FGL66_RS07880	COG0203	ribosomal protein L17
FGL66_RS07885	COG0202	RNA polymerase activity
FGL66_RS07890	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FGL66_RS07900	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FGL66_RS07915	COG0201	protein transport
FGL66_RS07925	COG1841	ribosomal large subunit assembly
FGL66_RS07930	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FGL66_RS07940	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FGL66_RS07945	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FGL66_RS07950	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FGL66_RS07960	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FGL66_RS07965	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FGL66_RS07975	COG0255	Belongs to the universal ribosomal protein uL29 family
FGL66_RS07985	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FGL66_RS07990	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FGL66_RS07995	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FGL66_RS08000	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FGL66_RS08005	COG0089	rRNA binding
FGL66_RS08010	COG0088	Forms part of the polypeptide exit tunnel
FGL66_RS08015	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FGL66_RS08030	COG2252	PERMEase
FGL66_RS08055	COG0436	Aminotransferase
FGL66_RS08060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FGL66_RS08065	COG2348	transferase activity, transferring amino-acyl groups
FGL66_RS08080	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FGL66_RS08085	COG0746	molybdenum cofactor guanylyltransferase activity
FGL66_RS08095	COG0314	molybdopterin synthase activity
FGL66_RS08105	COG0303	'Molybdopterin
FGL66_RS08115	COG0521	Mo-molybdopterin cofactor biosynthetic process
FGL66_RS08120	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FGL66_RS08125	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FGL66_RS08130	COG4149	molybdate abc transporter
FGL66_RS08135	COG0725	ABC transporter, periplasmic molybdate-binding protein
FGL66_RS08160	COG1686	Belongs to the peptidase S11 family
FGL66_RS08180	COG1268	BioY protein
FGL66_RS08190	COG2186	Transcriptional regulator
FGL66_RS08200	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FGL66_RS08205	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FGL66_RS08210	COG2832	Protein of unknown function (DUF454)
FGL66_RS08215	COG1960	acyl-CoA dehydrogenase activity
FGL66_RS08275	COG3383	formate dehydrogenase (NAD+) activity
FGL66_RS08280	COG1316	TRANSCRIPTIONal
FGL66_RS08300	COG1113	amino acid transport
FGL66_RS08320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FGL66_RS08325	COG0346	lactoylglutathione lyase activity
FGL66_RS08335	COG0385	Bile acid
FGL66_RS08355	COG1473	amidohydrolase
FGL66_RS08360	COG0659	secondary active sulfate transmembrane transporter activity
FGL66_RS08365	COG1228	amidohydrolase
FGL66_RS08370	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FGL66_RS08380	COG0583	DNA-binding transcription factor activity
FGL66_RS08395	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FGL66_RS08405	COG2017	converts alpha-aldose to the beta-anomer
FGL66_RS08410	COG1742	UPF0060 membrane protein
FGL66_RS08415	COG1668	transmembrane transport
FGL66_RS08420	COG4152	abc transporter atp-binding protein
FGL66_RS08440	COG3152	Membrane
FGL66_RS08445	COG2094	Belongs to the DNA glycosylase MPG family
FGL66_RS08470	COG2207	Transcriptional regulator
FGL66_RS08475	COG0786	glutamate:sodium symporter activity
FGL66_RS08480	COG0523	cobalamin synthesis protein
FGL66_RS08505	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FGL66_RS08510	COG4640	response to antibiotic
FGL66_RS08525	COG1136	(ABC) transporter
FGL66_RS08530	COG0577	efflux transmembrane transporter activity
FGL66_RS08540	COG3850	Histidine kinase
FGL66_RS08540	COG5002	protein histidine kinase activity
FGL66_RS08545	COG0579	oxidoreductase
FGL66_RS08555	COG1620	l-lactate permease
FGL66_RS08570	COG0604	alcohol dehydrogenase
FGL66_RS08575	COG0492	ferredoxin-NADP+ reductase activity
FGL66_RS08595	COG1283	sodium-dependent phosphate transmembrane transporter activity
FGL66_RS08605	COG1263	PTS System
FGL66_RS08605	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FGL66_RS08615	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FGL66_RS08630	COG0697	spore germination
FGL66_RS08635	COG1363	Peptidase, m42
FGL66_RS08645	COG4187	Peptidase family M20/M25/M40
FGL66_RS08650	COG2223	nitrite transmembrane transporter activity
FGL66_RS08655	COG2197	response regulator
FGL66_RS08660	COG4585	Histidine kinase
FGL66_RS08670	COG2181	nitrate reductase activity
FGL66_RS08675	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
FGL66_RS08680	COG1140	nitrate reductase beta subunit
FGL66_RS08685	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
FGL66_RS08690	COG1648	precorrin-2 dehydrogenase activity
FGL66_RS08690	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FGL66_RS08695	COG2146	nitrite reductase [NAD(P)H] activity
FGL66_RS08700	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FGL66_RS08705	COG1648	precorrin-2 dehydrogenase activity
FGL66_RS08710	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
FGL66_RS08715	COG0454	-acetyltransferase
FGL66_RS08730	COG0471	metal ion transport
FGL66_RS08740	COG1760	l-serine dehydratase
FGL66_RS08745	COG1760	l-serine dehydratase
FGL66_RS08765	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FGL66_RS08775	COG1126	abc transporter atp-binding protein
FGL66_RS08780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FGL66_RS08785	COG0765	amino acid transport
FGL66_RS08805	COG1929	Belongs to the glycerate kinase type-1 family
FGL66_RS08810	COG3764	Sortase (surface protein transpeptidase)
FGL66_RS08815	COG0110	maltose O-acetyltransferase activity
FGL66_RS08820	COG2271	Major facilitator Superfamily
FGL66_RS08825	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
FGL66_RS08830	COG1115	amino acid carrier protein
FGL66_RS08835	COG1132	(ABC) transporter
FGL66_RS08840	COG1132	(ABC) transporter
FGL66_RS08850	COG0159	tryptophan synthase activity
FGL66_RS08855	COG0133	tryptophan synthase activity
FGL66_RS08865	COG0134	indole-3-glycerol-phosphate synthase activity
FGL66_RS08870	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FGL66_RS08875	COG0512	Glutamine amidotransferase of anthranilate synthase
FGL66_RS08880	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FGL66_RS08885	COG4336	lyase activity
FGL66_RS08890	COG2855	membrane
FGL66_RS08895	COG1063	alcohol dehydrogenase
FGL66_RS08905	COG3835	regulator
FGL66_RS08920	COG2816	NAD+ diphosphatase activity
FGL66_RS08930	COG1028	Short-chain dehydrogenase reductase Sdr
FGL66_RS08945	COG2814	Major facilitator Superfamily
FGL66_RS08950	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
FGL66_RS08970	COG3942	CHAP domain
FGL66_RS08980	COG2357	RelA SpoT domain protein
FGL66_RS08985	COG0778	Nitroreductase
FGL66_RS08990	COG1846	Transcriptional regulator
FGL66_RS09000	COG4607	ABC-type enterochelin transport system periplasmic component
FGL66_RS09005	COG4604	ABC transporter, ATP-binding protein
FGL66_RS09010	COG4605	iron ion homeostasis
FGL66_RS09015	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FGL66_RS09035	COG0583	DNA-binding transcription factor activity
FGL66_RS09040	COG3189	MarR family transcriptional regulator
FGL66_RS09055	COG1136	(ABC) transporter
FGL66_RS09055	COG0577	efflux transmembrane transporter activity
FGL66_RS09060	COG1136	(ABC) transporter
FGL66_RS09075	COG0778	Nitroreductase
FGL66_RS09090	COG0438	transferase activity, transferring glycosyl groups
FGL66_RS09100	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FGL66_RS09105	COG1063	alcohol dehydrogenase
FGL66_RS09110	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FGL66_RS09115	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FGL66_RS09135	COG3942	CHAP domain
FGL66_RS09135	COG1705	Flagellar rod assembly protein muramidase FlgJ
FGL66_RS09140	COG0789	Transcriptional regulator
FGL66_RS09145	COG0596	Alpha beta hydrolase
FGL66_RS09155	COG2824	Alkylphosphonate utilization operon protein PhnA
FGL66_RS09160	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
FGL66_RS09165	COG1461	Dihydroxyacetone kinase
FGL66_RS09170	COG2376	Dihydroxyacetone kinase
FGL66_RS09175	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FGL66_RS09180	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FGL66_RS09190	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FGL66_RS09195	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FGL66_RS09200	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FGL66_RS09205	COG0131	Imidazoleglycerol-phosphate dehydratase
FGL66_RS09215	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FGL66_RS09220	COG0107	imidazoleglycerol-phosphate synthase activity
FGL66_RS09235	COG1012	belongs to the aldehyde dehydrogenase family
FGL66_RS09240	COG1510	regulation of RNA biosynthetic process
FGL66_RS09245	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FGL66_RS09250	COG2258	MOSC domain
FGL66_RS09255	COG3527	Alpha-acetolactate decarboxylase
FGL66_RS09260	COG1785	Belongs to the alkaline phosphatase family
FGL66_RS09265	COG2814	Major facilitator Superfamily
FGL66_RS09270	COG2226	methyltransferase
FGL66_RS09275	COG1957	nucleoside hydrolase
FGL66_RS09280	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FGL66_RS09285	COG4221	oxidoreductase activity
FGL66_RS09295	COG1028	Short-chain dehydrogenase reductase Sdr
FGL66_RS09300	COG3443	Belongs to the bacterial solute-binding protein 9 family
FGL66_RS09300	COG0803	Belongs to the bacterial solute-binding protein 9 family
FGL66_RS09305	COG0602	queuosine metabolic process
FGL66_RS09310	COG1328	CTP reductase activity
FGL66_RS09325	COG4932	domain protein
FGL66_RS09330	COG4932	domain protein
FGL66_RS09350	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FGL66_RS09375	COG0626	cystathionine gamma-synthase activity
FGL66_RS09380	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FGL66_RS09385	COG2272	Belongs to the type-B carboxylesterase lipase family
FGL66_RS09390	COG0733	neurotransmitter:sodium symporter activity
FGL66_RS09400	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FGL66_RS09405	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FGL66_RS09405	COG0574	Belongs to the PEP-utilizing enzyme family
FGL66_RS09450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FGL66_RS09450	COG0519	Catalyzes the synthesis of GMP from XMP
FGL66_RS09455	COG0517	IMP dehydrogenase activity
FGL66_RS09455	COG0516	GMP reductase activity
FGL66_RS09460	COG2233	PERMEase
FGL66_RS09465	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FGL66_RS09480	COG5183	chlorophyll binding
FGL66_RS09485	COG1823	symporter activity
FGL66_RS09490	COG0778	Nitroreductase
FGL66_RS09500	COG0450	alkyl hydroperoxide reductase
FGL66_RS09505	COG3634	alkyl hydroperoxide reductase activity
FGL66_RS09515	COG1464	Belongs to the NlpA lipoprotein family
FGL66_RS09520	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FGL66_RS09530	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FGL66_RS09535	COG2011	ABC-type metal ion transport system permease component
FGL66_RS09540	COG1464	Belongs to the NlpA lipoprotein family
FGL66_RS09545	COG1473	amidohydrolase
FGL66_RS09550	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FGL66_RS09560	COG0360	Binds together with S18 to 16S ribosomal RNA
FGL66_RS09565	COG0012	GTP binding
FGL66_RS09570	COG4481	Protein conserved in bacteria
FGL66_RS09575	COG0668	transmembrane transport
FGL66_RS09580	COG1475	DNA binding
FGL66_RS09585	COG0626	cystathionine gamma-synthase activity
FGL66_RS09590	COG0626	cystathionine gamma-synthase activity
FGL66_RS09595	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FGL66_RS09595	COG0646	methionine synthase
FGL66_RS09615	COG0357	Ribosomal RNA small subunit methyltransferase G
FGL66_RS09620	COG0445	tRNA wobble uridine modification
FGL66_RS09625	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FGL66_RS09630	COG0594	ribonuclease P activity