locus-tag	class	description
ISP08_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ISP08_RS00010	COG0592	DNA-directed DNA polymerase activity
ISP08_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ISP08_RS00030	COG0187	DNA topoisomerase II activity
ISP08_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ISP08_RS00040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ISP08_RS00045	COG2986	histidine ammonia-lyase
ISP08_RS00050	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ISP08_RS00065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ISP08_RS00075	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
ISP08_RS00080	COG0359	binds to the 23S rRNA
ISP08_RS00085	COG0305	Participates in initiation and elongation during chromosome replication
ISP08_RS00090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ISP08_RS00095	COG1819	glycosyl
ISP08_RS00120	COG0745	RESPONSE REGULATOR receiver
ISP08_RS00125	COG5002	protein histidine kinase activity
ISP08_RS00130	COG4863	YycH protein
ISP08_RS00140	COG1070	Carbohydrate kinase
ISP08_RS00145	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ISP08_RS00150	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ISP08_RS00160	COG0640	Transcriptional regulator
ISP08_RS00165	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ISP08_RS00170	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ISP08_RS00185	COG0640	Transcriptional regulator
ISP08_RS00210	COG2003	Belongs to the UPF0758 family
ISP08_RS00265	COG0789	Transcriptional regulator
ISP08_RS00275	COG0702	epimerase
ISP08_RS00280	COG2130	NADP-dependent
ISP08_RS00295	COG0702	epimerase
ISP08_RS00300	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
ISP08_RS00335	COG0415	Belongs to the DNA photolyase family
ISP08_RS00350	COG1388	LysM domain
ISP08_RS00355	COG0730	response to heat
ISP08_RS00360	COG1937	Protein conserved in bacteria
ISP08_RS00365	COG2210	Belongs to the sulfur carrier protein TusA family
ISP08_RS00370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISP08_RS00380	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ISP08_RS00385	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ISP08_RS00410	COG0789	Transcriptional regulator
ISP08_RS00410	COG4978	Transcriptional regulator
ISP08_RS00420	COG4195	phage-related replication protein
ISP08_RS00425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISP08_RS00430	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ISP08_RS00460	COG0601	transmembrane transport
ISP08_RS00470	COG0444	Belongs to the ABC transporter superfamily
ISP08_RS00475	COG1124	(ABC) transporter
ISP08_RS00495	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ISP08_RS00495	COG0463	Glycosyl transferase, family 2
ISP08_RS00505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISP08_RS00510	COG1733	regulation of RNA biosynthetic process
ISP08_RS00525	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISP08_RS00565	COG1131	(ABC) transporter
ISP08_RS00580	COG0438	transferase activity, transferring glycosyl groups
ISP08_RS00595	COG2814	Major facilitator Superfamily
ISP08_RS00600	COG0028	Belongs to the TPP enzyme family
ISP08_RS00605	COG3527	Alpha-acetolactate decarboxylase
ISP08_RS00610	COG1620	l-lactate permease
ISP08_RS00620	COG1253	flavin adenine dinucleotide binding
ISP08_RS00625	COG3275	phosphorelay sensor kinase activity
ISP08_RS00630	COG3279	Response regulator of the LytR AlgR family
ISP08_RS00635	COG1380	Effector of murein hydrolase LrgA
ISP08_RS00640	COG1346	cytolysis
ISP08_RS00645	COG2814	Major facilitator Superfamily
ISP08_RS00655	COG0583	DNA-binding transcription factor activity
ISP08_RS00660	COG0789	Transcriptional regulator
ISP08_RS00680	COG1129	ABC transporter
ISP08_RS00690	COG1132	(ABC) transporter
ISP08_RS00710	COG2814	Major facilitator Superfamily
ISP08_RS00715	COG1309	transcriptional regulator
ISP08_RS00720	COG0028	Belongs to the TPP enzyme family
ISP08_RS00725	COG3527	Alpha-acetolactate decarboxylase
ISP08_RS00730	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ISP08_RS00740	COG1309	transcriptional regulator
ISP08_RS00755	COG1028	Short-chain dehydrogenase reductase Sdr
ISP08_RS00760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISP08_RS00765	COG0471	metal ion transport
ISP08_RS00770	COG1064	alcohol dehydrogenase
ISP08_RS00780	COG1114	Component of the transport system for branched-chain amino acids
ISP08_RS00785	COG0463	Glycosyl transferase, family 2
ISP08_RS00785	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ISP08_RS00790	COG0833	amino acid
ISP08_RS00795	COG2040	homocysteine
ISP08_RS00805	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ISP08_RS00815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISP08_RS00820	COG1609	Transcriptional regulator
ISP08_RS00830	COG1869	D-ribose catabolic process
ISP08_RS00840	COG0697	spore germination
ISP08_RS00875	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ISP08_RS00880	COG1028	Short-chain dehydrogenase reductase Sdr
ISP08_RS00895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISP08_RS00900	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ISP08_RS00905	COG2807	transmembrane transport
ISP08_RS00910	COG0697	spore germination
ISP08_RS00915	COG2207	Transcriptional regulator
ISP08_RS00950	COG2409	Drug exporters of the RND superfamily
ISP08_RS00970	COG1609	Transcriptional regulator
ISP08_RS00980	COG0235	Class ii aldolase
ISP08_RS00985	COG2160	L-arabinose isomerase activity
ISP08_RS00995	COG1309	transcriptional regulator
ISP08_RS01025	COG1755	Isoprenylcysteine carboxyl methyltransferase
ISP08_RS01040	COG1012	belongs to the aldehyde dehydrogenase family
ISP08_RS01045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISP08_RS01050	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ISP08_RS01055	COG2271	Major facilitator Superfamily
ISP08_RS01060	COG1476	TRANSCRIPTIONal
ISP08_RS01070	COG1131	(ABC) transporter
ISP08_RS01090	COG0456	acetyltransferase
ISP08_RS01090	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ISP08_RS01095	COG0039	L-malate dehydrogenase activity
ISP08_RS01100	COG3620	sequence-specific DNA binding
ISP08_RS01105	COG0477	Major facilitator Superfamily
ISP08_RS01110	COG0584	glycerophosphoryl diester phosphodiesterase
ISP08_RS01115	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ISP08_RS01120	COG2226	methyltransferase
ISP08_RS01125	COG2851	Citrate transporter
ISP08_RS01135	COG0579	oxidoreductase
ISP08_RS01145	COG0668	transmembrane transport
ISP08_RS01150	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ISP08_RS01165	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
ISP08_RS01180	COG0415	Belongs to the DNA photolyase family
ISP08_RS01185	COG1388	LysM domain
ISP08_RS01195	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ISP08_RS01210	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
ISP08_RS01235	COG5002	protein histidine kinase activity
ISP08_RS01240	COG1028	Short-chain dehydrogenase reductase Sdr
ISP08_RS01245	COG1054	Belongs to the UPF0176 family
ISP08_RS01250	COG0402	S-adenosylhomocysteine deaminase activity
ISP08_RS01260	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISP08_RS01265	COG4605	iron ion homeostasis
ISP08_RS01270	COG4604	ABC transporter, ATP-binding protein
ISP08_RS01275	COG4607	ABC-type enterochelin transport system periplasmic component
ISP08_RS01285	COG3189	MarR family transcriptional regulator
ISP08_RS01290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ISP08_RS01300	COG4195	phage-related replication protein
ISP08_RS01325	COG0583	DNA-binding transcription factor activity
ISP08_RS01330	COG2814	Major facilitator Superfamily
ISP08_RS01345	COG1309	transcriptional regulator
ISP08_RS01355	COG2814	Major facilitator Superfamily
ISP08_RS01360	COG0640	Transcriptional regulator
ISP08_RS01390	COG2832	Protein of unknown function (DUF454)
ISP08_RS01395	COG0346	lactoylglutathione lyase activity
ISP08_RS01405	COG0406	alpha-ribazole phosphatase activity
ISP08_RS01410	COG4106	trans-aconitate 2-methyltransferase activity
ISP08_RS01415	COG0679	Auxin Efflux Carrier
ISP08_RS01420	COG3942	CHAP domain
ISP08_RS01430	COG3386	PFAM SMP-30 Gluconolaconase
ISP08_RS01435	COG1288	antiporter activity
ISP08_RS01455	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ISP08_RS01475	COG0737	Belongs to the 5'-nucleotidase family
ISP08_RS01480	COG0129	dihydroxy-acid dehydratase activity
ISP08_RS01485	COG1113	amino acid transport
ISP08_RS01490	COG0753	catalase activity
ISP08_RS01495	COG0183	Belongs to the thiolase family
ISP08_RS01500	COG1024	Enoyl-CoA hydratase
ISP08_RS01500	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISP08_RS01505	COG1960	acyl-CoA dehydrogenase activity
ISP08_RS01520	COG1028	Short-chain dehydrogenase reductase Sdr
ISP08_RS01525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISP08_RS01535	COG1279	arginine transmembrane transporter activity
ISP08_RS01540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISP08_RS01560	COG0583	DNA-binding transcription factor activity
ISP08_RS01580	COG1012	belongs to the aldehyde dehydrogenase family
ISP08_RS01590	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ISP08_RS01595	COG3002	Belongs to the UPF0753 family
ISP08_RS01600	COG5609	conserved protein (DUF2294)
ISP08_RS01605	COG0477	Major facilitator Superfamily
ISP08_RS01615	COG2814	Major facilitator Superfamily
ISP08_RS01620	COG0583	DNA-binding transcription factor activity
ISP08_RS01635	COG3192	ethanolamine utilization protein
ISP08_RS01640	COG1028	Short-chain dehydrogenase reductase Sdr
ISP08_RS01650	COG1012	belongs to the aldehyde dehydrogenase family
ISP08_RS01660	COG0175	sulfate reduction
ISP08_RS01665	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ISP08_RS01670	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ISP08_RS01690	COG0730	response to heat
ISP08_RS01695	COG2046	Belongs to the sulfate adenylyltransferase family
ISP08_RS01700	COG0529	Catalyzes the synthesis of activated sulfate
ISP08_RS01705	COG1017	nitric oxide dioxygenase activity
ISP08_RS01705	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ISP08_RS01715	COG0730	response to heat
ISP08_RS01720	COG0778	Nitroreductase
ISP08_RS01725	COG1473	amidohydrolase
ISP08_RS01735	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
ISP08_RS01740	COG1691	(AIR) carboxylase
ISP08_RS01745	COG1606	tRNA processing
ISP08_RS01750	COG3875	lactate racemase activity
ISP08_RS01770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISP08_RS01770	COG0574	Belongs to the PEP-utilizing enzyme family
ISP08_RS01775	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ISP08_RS01780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ISP08_RS01785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISP08_RS01790	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ISP08_RS01795	COG1012	belongs to the aldehyde dehydrogenase family
ISP08_RS01800	COG3588	fructose-bisphosphate aldolase
ISP08_RS01805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISP08_RS01815	COG1510	regulation of RNA biosynthetic process
ISP08_RS01820	COG1012	belongs to the aldehyde dehydrogenase family
ISP08_RS01825	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
ISP08_RS01835	COG0477	Major facilitator Superfamily
ISP08_RS01845	COG2271	Major facilitator Superfamily
ISP08_RS01850	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ISP08_RS01860	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ISP08_RS01870	COG1957	nucleoside hydrolase
ISP08_RS01880	COG0477	Major facilitator Superfamily
ISP08_RS01885	COG0531	amino acid
ISP08_RS01890	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISP08_RS01895	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ISP08_RS01900	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ISP08_RS01905	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ISP08_RS01910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISP08_RS01915	COG1070	Carbohydrate kinase
ISP08_RS01925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ISP08_RS01935	COG2022	thiamine diphosphate biosynthetic process
ISP08_RS01940	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ISP08_RS01945	COG2814	Major facilitator Superfamily
ISP08_RS01965	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ISP08_RS01970	COG1940	carbohydrate kinase activity
ISP08_RS01975	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ISP08_RS01995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ISP08_RS02000	COG0765	amino acid transport
ISP08_RS02005	COG1126	abc transporter atp-binding protein
ISP08_RS02010	COG3711	transcriptional antiterminator
ISP08_RS02015	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISP08_RS02030	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ISP08_RS02035	COG1482	cell wall glycoprotein biosynthetic process
ISP08_RS02040	COG1940	carbohydrate kinase activity
ISP08_RS02060	COG0626	cystathionine gamma-synthase activity
ISP08_RS02065	COG1131	(ABC) transporter
ISP08_RS02075	COG1309	transcriptional regulator
ISP08_RS02085	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISP08_RS02100	COG0561	phosphatase activity
ISP08_RS02110	COG0167	dihydroorotate dehydrogenase activity
ISP08_RS02115	COG3001	Fructosamine kinase
ISP08_RS02150	COG1388	LysM domain
ISP08_RS02155	COG0436	Aminotransferase
ISP08_RS02160	COG2608	mercury ion transmembrane transporter activity
ISP08_RS02165	COG2217	Heavy metal translocating P-type atpase
ISP08_RS02170	COG1136	(ABC) transporter
ISP08_RS02175	COG0577	efflux transmembrane transporter activity
ISP08_RS02185	COG0471	metal ion transport
ISP08_RS02190	COG5505	Protein of unknown function (DUF819)
ISP08_RS02200	COG4336	lyase activity
ISP08_RS02215	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
ISP08_RS02220	COG1012	belongs to the aldehyde dehydrogenase family
ISP08_RS02230	COG3961	Belongs to the TPP enzyme family
ISP08_RS02235	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ISP08_RS02240	COG3425	synthase
ISP08_RS02255	COG1388	LysM domain
ISP08_RS02255	COG3942	CHAP domain
ISP08_RS02260	COG0583	DNA-binding transcription factor activity
ISP08_RS02265	COG1380	Effector of murein hydrolase LrgA
ISP08_RS02275	COG0028	Belongs to the TPP enzyme family
ISP08_RS02280	COG1288	antiporter activity
ISP08_RS02305	COG1247	-acetyltransferase
ISP08_RS02310	COG0657	acetylesterase activity
ISP08_RS02330	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ISP08_RS02335	COG1063	alcohol dehydrogenase
ISP08_RS02340	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ISP08_RS02365	COG3764	Sortase (surface protein transpeptidase)
ISP08_RS02375	COG0517	IMP dehydrogenase activity
ISP08_RS02375	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ISP08_RS02380	COG2190	(PTS) system
ISP08_RS02380	COG1263	PTS System
ISP08_RS02380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISP08_RS02385	COG0363	glucosamine-6-phosphate deaminase activity
ISP08_RS02400	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ISP08_RS02405	COG2249	NAD(P)H dehydrogenase (quinone) activity
ISP08_RS02410	COG0561	phosphatase activity
ISP08_RS02415	COG0778	Nitroreductase
ISP08_RS02430	COG1132	(ABC) transporter
ISP08_RS02435	COG1132	(ABC) transporter
ISP08_RS02450	COG1012	belongs to the aldehyde dehydrogenase family
ISP08_RS02455	COG1846	Transcriptional regulator
ISP08_RS02460	COG0346	lactoylglutathione lyase activity
ISP08_RS02465	COG0400	carboxylic ester hydrolase activity
ISP08_RS02470	COG1335	isochorismatase
ISP08_RS02475	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
ISP08_RS02480	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ISP08_RS02485	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ISP08_RS02495	COG0586	Pfam SNARE associated Golgi protein
ISP08_RS02500	COG2271	Major facilitator Superfamily
ISP08_RS02515	COG4876	unkown
ISP08_RS02520	COG2808	Putative FMN-binding domain
ISP08_RS02525	COG2357	RelA SpoT domain protein
ISP08_RS02530	COG1802	Transcriptional regulator
ISP08_RS02535	COG1070	Carbohydrate kinase
ISP08_RS02540	COG2610	gluconate transmembrane transporter activity
ISP08_RS02550	COG4221	oxidoreductase activity
ISP08_RS02560	COG0107	imidazoleglycerol-phosphate synthase activity
ISP08_RS02565	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ISP08_RS02570	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ISP08_RS02575	COG0131	Imidazoleglycerol-phosphate dehydratase
ISP08_RS02580	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ISP08_RS02585	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ISP08_RS02590	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ISP08_RS02600	COG1028	Short-chain dehydrogenase reductase Sdr
ISP08_RS02605	COG1363	Peptidase, m42
ISP08_RS02610	COG0069	glutamate synthase activity
ISP08_RS02615	COG4619	ABC transporter
ISP08_RS02620	COG0390	transport system, permease component
ISP08_RS02625	COG2814	Major facilitator Superfamily
ISP08_RS02630	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
ISP08_RS02635	COG1309	transcriptional regulator
ISP08_RS02640	COG3246	L-lysine catabolic process to acetate
ISP08_RS02645	COG1250	3-hydroxyacyl-CoA dehydrogenase
ISP08_RS02670	COG1174	glycine betaine transport
ISP08_RS02685	COG4187	Peptidase family M20/M25/M40
ISP08_RS02700	COG0025	NhaP-type Na H and K H
ISP08_RS02720	COG2814	Major facilitator Superfamily
ISP08_RS02725	COG1929	Belongs to the glycerate kinase type-1 family
ISP08_RS02735	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ISP08_RS02740	COG0741	lytic transglycosylase activity
ISP08_RS02745	COG0588	phosphoglycerate mutase activity
ISP08_RS02755	COG2814	Major facilitator Superfamily
ISP08_RS02780	COG2353	YceI-like domain
ISP08_RS02795	COG1959	2 iron, 2 sulfur cluster binding
ISP08_RS02800	COG2116	formate transmembrane transporter activity
ISP08_RS02805	COG0454	-acetyltransferase
ISP08_RS02810	COG0071	Belongs to the small heat shock protein (HSP20) family
ISP08_RS02815	COG1846	Transcriptional regulator
ISP08_RS02860	COG1283	sodium-dependent phosphate transmembrane transporter activity
ISP08_RS02865	COG1028	Short-chain dehydrogenase reductase Sdr
ISP08_RS02870	COG1349	DNA-binding transcription factor activity
ISP08_RS02875	COG1063	alcohol dehydrogenase
ISP08_RS02880	COG2376	Dihydroxyacetone kinase
ISP08_RS02890	COG0698	ribose 5-phosphate isomerase
ISP08_RS02900	COG4549	nuclear export factor GLE1
ISP08_RS02910	COG0492	ferredoxin-NADP+ reductase activity
ISP08_RS02920	COG2814	Major facilitator Superfamily
ISP08_RS02925	COG0604	alcohol dehydrogenase
ISP08_RS02940	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ISP08_RS02955	COG3850	Histidine kinase
ISP08_RS02955	COG5002	protein histidine kinase activity
ISP08_RS02960	COG0745	RESPONSE REGULATOR receiver
ISP08_RS02965	COG0577	efflux transmembrane transporter activity
ISP08_RS02985	COG1033	growth of symbiont in host cell
ISP08_RS02985	COG2409	Drug exporters of the RND superfamily
ISP08_RS02990	COG4640	response to antibiotic
ISP08_RS02995	COG2814	Major facilitator Superfamily
ISP08_RS03005	COG1566	PFAM secretion protein HlyD family protein
ISP08_RS03010	COG2814	Major facilitator Superfamily
ISP08_RS03035	COG0598	Magnesium transport protein CorA
ISP08_RS03040	COG1304	FMN binding
ISP08_RS03045	COG0786	glutamate:sodium symporter activity
ISP08_RS03050	COG1757	Na H antiporter
ISP08_RS03055	COG2094	Belongs to the DNA glycosylase MPG family
ISP08_RS03060	COG3152	Membrane
ISP08_RS03065	COG1069	ribulokinase activity
ISP08_RS03070	COG4152	abc transporter atp-binding protein
ISP08_RS03075	COG1668	transmembrane transport
ISP08_RS03090	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ISP08_RS03095	COG1266	CAAX protease self-immunity
ISP08_RS03100	COG0010	Belongs to the arginase family
ISP08_RS03110	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ISP08_RS03115	COG1228	amidohydrolase
ISP08_RS03120	COG0659	secondary active sulfate transmembrane transporter activity
ISP08_RS03125	COG1473	amidohydrolase
ISP08_RS03130	COG1028	Short-chain dehydrogenase reductase Sdr
ISP08_RS03135	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ISP08_RS03150	COG1737	Transcriptional regulator
ISP08_RS03155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISP08_RS03155	COG1263	PTS System
ISP08_RS03165	COG0385	Bile acid
ISP08_RS03170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ISP08_RS03185	COG1113	amino acid transport
ISP08_RS03190	COG1737	Transcriptional regulator
ISP08_RS03200	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ISP08_RS03215	COG1349	DNA-binding transcription factor activity
ISP08_RS03220	COG0483	inositol monophosphate 1-phosphatase activity
ISP08_RS03225	COG1316	TRANSCRIPTIONal
ISP08_RS03230	COG3383	formate dehydrogenase (NAD+) activity
ISP08_RS03255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISP08_RS03260	COG2076	Multidrug Resistance protein
ISP08_RS03265	COG2076	Multidrug Resistance protein
ISP08_RS03270	COG3942	CHAP domain
ISP08_RS03285	COG1757	Na H antiporter
ISP08_RS03290	COG3942	CHAP domain
ISP08_RS03305	COG1960	acyl-CoA dehydrogenase activity
ISP08_RS03310	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISP08_RS03315	COG1268	BioY protein
ISP08_RS03330	COG1609	Transcriptional regulator
ISP08_RS03335	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ISP08_RS03340	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ISP08_RS03345	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
ISP08_RS03350	COG0725	ABC transporter, periplasmic molybdate-binding protein
ISP08_RS03355	COG4149	molybdate abc transporter
ISP08_RS03365	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ISP08_RS03375	COG0315	cyclic pyranopterin monophosphate synthase activity
ISP08_RS03385	COG1763	Mo-molybdopterin cofactor biosynthetic process
ISP08_RS03390	COG0314	molybdopterin synthase activity
ISP08_RS03400	COG0746	molybdenum cofactor guanylyltransferase activity
ISP08_RS03405	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ISP08_RS03415	COG2814	Major facilitator Superfamily
ISP08_RS03435	COG2348	transferase activity, transferring amino-acyl groups
ISP08_RS03440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ISP08_RS03465	COG4975	Glucose uptake
ISP08_RS03475	COG0551	DNA topoisomerase type I activity
ISP08_RS03475	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISP08_RS03480	COG2252	PERMEase
ISP08_RS03495	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ISP08_RS03500	COG0088	Forms part of the polypeptide exit tunnel
ISP08_RS03505	COG0089	rRNA binding
ISP08_RS03510	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ISP08_RS03515	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ISP08_RS03520	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ISP08_RS03525	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ISP08_RS03530	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ISP08_RS03535	COG0255	Belongs to the universal ribosomal protein uL29 family
ISP08_RS03540	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ISP08_RS03545	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ISP08_RS03550	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ISP08_RS03555	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ISP08_RS03560	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ISP08_RS03565	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ISP08_RS03570	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ISP08_RS03575	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ISP08_RS03580	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ISP08_RS03585	COG1841	ribosomal large subunit assembly
ISP08_RS03595	COG0201	protein transport
ISP08_RS03610	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ISP08_RS03615	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ISP08_RS03620	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ISP08_RS03625	COG0202	RNA polymerase activity
ISP08_RS03630	COG0203	ribosomal protein L17
ISP08_RS03635	COG1122	ATPase activity
ISP08_RS03640	COG1122	ATPase activity
ISP08_RS03650	COG0101	tRNA pseudouridine synthase activity
ISP08_RS03655	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ISP08_RS03660	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ISP08_RS03665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISP08_RS03670	COG2130	NADP-dependent
ISP08_RS03675	COG0604	alcohol dehydrogenase
ISP08_RS03690	COG1302	Protein conserved in bacteria
ISP08_RS03700	COG2814	Major facilitator Superfamily
ISP08_RS03705	COG4264	IucA IucC family
ISP08_RS03710	COG3457	Alanine racemase
ISP08_RS03715	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ISP08_RS03720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISP08_RS03725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISP08_RS03730	COG3314	Sporulation integral membrane protein YlbJ
ISP08_RS03735	COG2329	Antibiotic biosynthesis monooxygenase
ISP08_RS03745	COG1988	membrane-bound metal-dependent
ISP08_RS03750	COG4284	Utp--glucose-1-phosphate uridylyltransferase
ISP08_RS03755	COG1272	protein, Hemolysin III
ISP08_RS03770	COG2814	Major facilitator Superfamily
ISP08_RS03775	COG0489	protein tyrosine kinase activity
ISP08_RS03830	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ISP08_RS03840	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ISP08_RS03845	COG0246	Mannitol dehydrogenase
ISP08_RS03855	COG3711	transcriptional antiterminator
ISP08_RS03870	COG1119	ATPase activity
ISP08_RS03875	COG0561	phosphatase activity
ISP08_RS03895	COG0640	Transcriptional regulator
ISP08_RS03900	COG0702	epimerase
ISP08_RS03905	COG2186	Transcriptional regulator
ISP08_RS03910	COG1482	cell wall glycoprotein biosynthetic process
ISP08_RS03930	COG0783	Belongs to the Dps family
ISP08_RS03935	COG0813	purine-nucleoside phosphorylase activity
ISP08_RS03940	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ISP08_RS03945	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ISP08_RS03950	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ISP08_RS03960	COG1854	S-ribosylhomocysteine lyase activity
ISP08_RS03980	COG5146	pantothenate kinase activity
ISP08_RS03990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ISP08_RS04000	COG0504	CTP synthase activity
ISP08_RS04010	COG0191	fructose-bisphosphate aldolase activity
ISP08_RS04015	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ISP08_RS04025	COG1012	belongs to the aldehyde dehydrogenase family
ISP08_RS04030	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ISP08_RS04035	COG0254	rRNA binding
ISP08_RS04045	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ISP08_RS04050	COG2890	protein-(glutamine-N5) methyltransferase activity
ISP08_RS04055	COG0009	L-threonylcarbamoyladenylate synthase
ISP08_RS04060	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ISP08_RS04065	COG4475	Protein of unknown function (DUF436)
ISP08_RS04070	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ISP08_RS04075	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ISP08_RS04080	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ISP08_RS04090	COG0356	it plays a direct role in the translocation of protons across the membrane
ISP08_RS04095	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ISP08_RS04100	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ISP08_RS04105	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ISP08_RS04110	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ISP08_RS04115	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ISP08_RS04120	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ISP08_RS04125	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ISP08_RS04130	COG4836	Membrane
ISP08_RS04135	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ISP08_RS04150	COG0629	single-stranded DNA binding
ISP08_RS04155	COG1388	LysM domain
ISP08_RS04160	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ISP08_RS04170	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ISP08_RS04175	COG0352	thiamine-phosphate diphosphorylase activity
ISP08_RS04180	COG0706	membrane insertase activity
ISP08_RS04185	COG1418	mRNA catabolic process
ISP08_RS04195	COG1937	Protein conserved in bacteria
ISP08_RS04210	COG0772	Belongs to the SEDS family
ISP08_RS04215	COG1181	Belongs to the D-alanine--D-alanine ligase family
ISP08_RS04220	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ISP08_RS04225	COG0513	Belongs to the DEAD box helicase family
ISP08_RS04235	COG3428	Bacterial PH domain
ISP08_RS04250	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ISP08_RS04260	COG2337	Toxic component of a toxin-antitoxin (TA) module
ISP08_RS04265	COG2208	phosphoserine phosphatase activity
ISP08_RS04280	COG1191	sigma factor activity
ISP08_RS04285	COG2183	response to ionizing radiation
ISP08_RS04290	COG3091	SprT-like family
ISP08_RS04320	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ISP08_RS04325	COG0066	3-isopropylmalate dehydratase activity
ISP08_RS04330	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ISP08_RS04335	COG0473	3-isopropylmalate dehydrogenase activity
ISP08_RS04340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ISP08_RS04345	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ISP08_RS04350	COG0440	acetolactate synthase activity
ISP08_RS04355	COG0028	Belongs to the TPP enzyme family
ISP08_RS04360	COG0129	dihydroxy-acid dehydratase activity
ISP08_RS04365	COG0802	atpase or kinase
ISP08_RS04370	COG1214	PFAM Peptidase M22, glycoprotease
ISP08_RS04375	COG0456	acetyltransferase
ISP08_RS04380	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ISP08_RS04395	COG0488	(ABC) transporter
ISP08_RS04400	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ISP08_RS04405	COG2391	methyltransferase activity
ISP08_RS04410	COG0425	Belongs to the sulfur carrier protein TusA family
ISP08_RS04415	COG1621	beta-fructofuranosidase activity
ISP08_RS04420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ISP08_RS04425	COG3279	Response regulator of the LytR AlgR family
ISP08_RS04440	COG4512	PFAM Accessory gene regulator B
ISP08_RS04445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISP08_RS04465	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ISP08_RS04470	COG0459	protein refolding
ISP08_RS04495	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ISP08_RS04505	COG1131	(ABC) transporter
ISP08_RS04550	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ISP08_RS04555	COG2706	6-phosphogluconolactonase activity
ISP08_RS04560	COG1012	belongs to the aldehyde dehydrogenase family
ISP08_RS04565	COG1227	inorganic diphosphatase activity
ISP08_RS04570	COG1335	isochorismatase
ISP08_RS04580	COG0077	Prephenate dehydratase
ISP08_RS04590	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ISP08_RS04595	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ISP08_RS04600	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
ISP08_RS04610	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ISP08_RS04615	COG4496	protein, YerC YecD
ISP08_RS04620	COG1876	peptidase activity
ISP08_RS04625	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
ISP08_RS04635	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ISP08_RS04645	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ISP08_RS04650	COG0154	amidase activity
ISP08_RS04655	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ISP08_RS04660	COG1597	lipid kinase activity
ISP08_RS04675	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ISP08_RS04685	COG1528	Iron-storage protein
ISP08_RS04700	COG4129	membrane
ISP08_RS04705	COG0024	Methionine aminopeptidase
ISP08_RS04720	COG4585	Histidine kinase
ISP08_RS04725	COG2197	response regulator
ISP08_RS04730	COG1295	ribonuclease BN
ISP08_RS04745	COG4840	Belongs to the UPF0435 family
ISP08_RS04750	COG2309	aminopeptidase activity
ISP08_RS04755	COG1607	acyl-coa hydrolase
ISP08_RS04760	COG0535	radical SAM domain protein
ISP08_RS04770	COG0693	protein deglycase activity
ISP08_RS04775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISP08_RS04780	COG2137	regulation of response to DNA damage stimulus
ISP08_RS04790	COG1388	LysM domain
ISP08_RS04790	COG1134	teichoic acid transport
ISP08_RS04800	COG1988	membrane-bound metal-dependent
ISP08_RS04805	COG1194	a g-specific adenine glycosylase
ISP08_RS04810	COG3557	Belongs to the UPF0374 family
ISP08_RS04820	COG4129	membrane
ISP08_RS04825	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ISP08_RS04830	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ISP08_RS04835	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISP08_RS04840	COG0735	belongs to the Fur family
ISP08_RS05005	COG0730	response to heat
ISP08_RS05010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISP08_RS05015	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ISP08_RS05020	COG0531	amino acid
ISP08_RS05030	COG0765	amino acid transport
ISP08_RS05035	COG1126	abc transporter atp-binding protein
ISP08_RS05040	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ISP08_RS05050	COG0363	glucosamine-6-phosphate deaminase activity
ISP08_RS05065	COG0114	fumarate hydratase activity
ISP08_RS05070	COG0564	pseudouridine synthase activity
ISP08_RS05075	COG2203	Gaf domain
ISP08_RS05075	COG4585	Histidine kinase
ISP08_RS05080	COG2197	response regulator
ISP08_RS05085	COG1301	dicarboxylic acid transport
ISP08_RS05090	COG0788	formyltetrahydrofolate deformylase activity
ISP08_RS05100	COG4399	Belongs to the UPF0754 family
ISP08_RS05105	COG3679	Belongs to the UPF0342 family
ISP08_RS05110	COG0420	3'-5' exonuclease activity
ISP08_RS05115	COG4717	serine-type aminopeptidase activity
ISP08_RS05120	COG3481	metal-dependent phosphohydrolase, HD sub domain
ISP08_RS05125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ISP08_RS05140	COG0537	adenosine 5'-monophosphoramidase activity
ISP08_RS05145	COG1131	(ABC) transporter
ISP08_RS05150	COG4473	ABC transporter
ISP08_RS05160	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ISP08_RS05165	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ISP08_RS05170	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ISP08_RS05175	COG3545	Serine hydrolase
ISP08_RS05230	COG1418	mRNA catabolic process
ISP08_RS05290	COG0110	maltose O-acetyltransferase activity
ISP08_RS05305	COG0438	transferase activity, transferring glycosyl groups
ISP08_RS05305	COG0297	glycogen (starch) synthase activity
ISP08_RS05310	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ISP08_RS05315	COG0110	maltose O-acetyltransferase activity
ISP08_RS05320	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ISP08_RS05325	COG1917	Cupin 2, conserved barrel domain protein
ISP08_RS05325	COG2207	Transcriptional regulator
ISP08_RS05330	COG0318	PFAM AMP-dependent synthetase and ligase
ISP08_RS05340	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ISP08_RS05345	COG0494	nUDIX hydrolase
ISP08_RS05350	COG1506	peptidase
ISP08_RS05355	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ISP08_RS05360	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ISP08_RS05370	COG0656	L-ascorbic acid biosynthetic process
ISP08_RS05375	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ISP08_RS05380	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ISP08_RS05390	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ISP08_RS05395	COG2207	Transcriptional regulator
ISP08_RS05395	COG1917	Cupin 2, conserved barrel domain protein
ISP08_RS05435	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISP08_RS05435	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ISP08_RS05440	COG0307	riboflavin synthase, alpha
ISP08_RS05445	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ISP08_RS05445	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ISP08_RS05450	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ISP08_RS05455	COG0506	proline dehydrogenase activity
ISP08_RS05460	COG2267	carboxylic ester hydrolase activity
ISP08_RS05465	COG0039	L-malate dehydrogenase activity
ISP08_RS05475	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ISP08_RS05480	COG1242	4 iron, 4 sulfur cluster binding
ISP08_RS05485	COG2814	Major facilitator Superfamily
ISP08_RS05490	COG0495	leucyl-tRNA aminoacylation
ISP08_RS05500	COG2081	HI0933 family
ISP08_RS05505	COG2244	polysaccharide biosynthetic process
ISP08_RS05510	COG1187	pseudouridine synthase activity
ISP08_RS05520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISP08_RS05530	COG0510	thiamine kinase activity
ISP08_RS05535	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ISP08_RS05540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISP08_RS05550	COG1363	Peptidase, m42
ISP08_RS05555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISP08_RS05560	COG4848	Belongs to the UPF0354 family
ISP08_RS05565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ISP08_RS05570	COG1674	ftsk spoiiie
ISP08_RS05575	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ISP08_RS05580	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ISP08_RS05590	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ISP08_RS05590	COG1605	Chorismate mutase
ISP08_RS05595	COG1609	Transcriptional regulator
ISP08_RS05600	COG0123	including yeast histone deacetylase and acetoin utilization protein
ISP08_RS05605	COG0454	-acetyltransferase
ISP08_RS05610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ISP08_RS05620	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISP08_RS05625	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ISP08_RS05630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISP08_RS05635	COG0204	Acyl-transferase
ISP08_RS05640	COG1263	PTS System
ISP08_RS05640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISP08_RS05650	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ISP08_RS05660	COG1764	response to oxidative stress
ISP08_RS05665	COG0584	glycerophosphoryl diester phosphodiesterase
ISP08_RS05675	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ISP08_RS05680	COG1956	GAF domain-containing protein
ISP08_RS05685	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
ISP08_RS05690	COG1104	cysteine desulfurase activity
ISP08_RS05695	COG0301	tRNA thio-modification
ISP08_RS05700	COG0730	response to heat
ISP08_RS05705	COG0616	signal peptide processing
ISP08_RS05710	COG1714	RDD family
ISP08_RS05715	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ISP08_RS05720	COG0827	DNA restriction-modification system
ISP08_RS05725	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ISP08_RS05730	COG0589	response to stress
ISP08_RS05735	COG0686	Belongs to the AlaDH PNT family
ISP08_RS05740	COG3142	Participates in the control of copper homeostasis
ISP08_RS05745	COG0006	proline dipeptidase activity
ISP08_RS05750	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ISP08_RS05760	COG4109	DRTGG domain
ISP08_RS05765	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ISP08_RS05770	COG0587	DNA-directed DNA polymerase activity
ISP08_RS05775	COG0281	malic enzyme
ISP08_RS05780	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ISP08_RS05785	COG0825	malonyl-CoA metabolic process
ISP08_RS05790	COG0205	6-phosphofructokinase activity
ISP08_RS05795	COG0469	pyruvate kinase activity
ISP08_RS05800	COG1113	amino acid transport
ISP08_RS05805	COG0372	Belongs to the citrate synthase family
ISP08_RS05810	COG0538	isocitrate dehydrogenase activity
ISP08_RS05815	COG0745	RESPONSE REGULATOR receiver
ISP08_RS05820	COG5002	protein histidine kinase activity
ISP08_RS05825	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISP08_RS05825	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISP08_RS05835	COG0237	dephospho-CoA kinase activity
ISP08_RS05840	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ISP08_RS05845	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ISP08_RS05855	COG1484	DNA-dependent DNA replication
ISP08_RS05860	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ISP08_RS05865	COG0833	amino acid
ISP08_RS05870	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ISP08_RS05875	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ISP08_RS05880	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ISP08_RS05895	COG0544	peptidyl-prolyl cis-trans isomerase activity
ISP08_RS05900	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ISP08_RS05905	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ISP08_RS05910	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ISP08_RS05920	COG0181	hydroxymethylbilane synthase activity
ISP08_RS05930	COG0113	porphobilinogen synthase activity
ISP08_RS05935	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ISP08_RS05945	COG2818	Glycosylase
ISP08_RS05950	COG0525	valine-tRNA ligase activity
ISP08_RS05955	COG0285	dihydrofolate synthase activity
ISP08_RS05965	COG2003	Belongs to the UPF0758 family
ISP08_RS05970	COG0772	Belongs to the SEDS family
ISP08_RS05975	COG1316	TRANSCRIPTIONal
ISP08_RS06015	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ISP08_RS06020	COG2868	ribosomal protein
ISP08_RS06025	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ISP08_RS06030	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ISP08_RS06035	COG4492	Belongs to the UPF0735 family
ISP08_RS06045	COG2255	four-way junction helicase activity
ISP08_RS06050	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ISP08_RS06055	COG0343	queuine tRNA-ribosyltransferase activity
ISP08_RS06060	COG1862	Preprotein translocase
ISP08_RS06065	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISP08_RS06065	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ISP08_RS06070	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ISP08_RS06070	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ISP08_RS06080	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ISP08_RS06085	COG1490	D-aminoacyl-tRNA deacylase activity
ISP08_RS06090	COG0860	N-Acetylmuramoyl-L-alanine amidase
ISP08_RS06095	COG0124	histidyl-tRNA synthetase
ISP08_RS06100	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ISP08_RS06110	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ISP08_RS06115	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ISP08_RS06120	COG1959	2 iron, 2 sulfur cluster binding
ISP08_RS06135	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISP08_RS06140	COG0488	(ABC) transporter
ISP08_RS06145	COG1104	cysteine desulfurase activity
ISP08_RS06150	COG0482	sulfurtransferase activity
ISP08_RS06160	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ISP08_RS06165	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ISP08_RS06170	COG4472	Bacterial protein of unknown function (DUF965)
ISP08_RS06175	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ISP08_RS06180	COG3906	Belongs to the UPF0473 family
ISP08_RS06185	COG4122	O-methyltransferase activity
ISP08_RS06190	COG0826	peptidase U32
ISP08_RS06195	COG0826	peptidase U32
ISP08_RS06200	COG0572	uridine kinase
ISP08_RS06205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ISP08_RS06210	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ISP08_RS06215	COG1984	allophanate hydrolase subunit 2
ISP08_RS06220	COG0511	ligase activity, forming carbon-carbon bonds
ISP08_RS06225	COG0439	Biotin carboxylase
ISP08_RS06230	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ISP08_RS06235	COG1914	H( )-stimulated, divalent metal cation uptake system
ISP08_RS06245	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
ISP08_RS06250	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ISP08_RS06255	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ISP08_RS06260	COG1534	Rna-binding protein
ISP08_RS06265	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ISP08_RS06270	COG1713	HD superfamily hydrolase involved in NAD metabolism
ISP08_RS06275	COG0799	negative regulation of ribosome biogenesis
ISP08_RS06280	COG2226	methyltransferase
ISP08_RS06285	COG1596	polysaccharide export
ISP08_RS06285	COG1555	photosystem II stabilization
ISP08_RS06290	COG2131	deaminase
ISP08_RS06295	COG0658	competence protein
ISP08_RS06295	COG2333	competence protein COMEC
ISP08_RS06300	COG1466	dna polymerase III delta subunit
ISP08_RS06305	COG0268	Binds directly to 16S ribosomal RNA
ISP08_RS06310	COG0481	GTPase activity
ISP08_RS06315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ISP08_RS06320	COG1420	regulation of RNA biosynthetic process
ISP08_RS06325	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ISP08_RS06330	COG0443	Heat shock 70 kDa protein
ISP08_RS06335	COG0484	heat shock protein binding
ISP08_RS06340	COG2264	protein methyltransferase activity
ISP08_RS06345	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ISP08_RS06350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ISP08_RS06360	COG1030	water channel activity
ISP08_RS06365	COG4864	UPF0365 protein
ISP08_RS06375	COG1702	phosphate starvation-inducible protein PhoH
ISP08_RS06380	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ISP08_RS06390	COG0295	cytidine deaminase activity
ISP08_RS06395	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ISP08_RS06400	COG1381	Involved in DNA repair and RecF pathway recombination
ISP08_RS06405	COG0423	glycine-tRNA ligase activity
ISP08_RS06410	COG0517	IMP dehydrogenase activity
ISP08_RS06415	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ISP08_RS06425	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ISP08_RS06430	COG2384	SAM-dependent methyltransferase
ISP08_RS06440	COG0513	Belongs to the DEAD box helicase family
ISP08_RS06445	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ISP08_RS06450	COG1121	(ABC) transporter
ISP08_RS06455	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISP08_RS06465	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ISP08_RS06470	COG0768	penicillin binding
ISP08_RS06475	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ISP08_RS06480	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ISP08_RS06490	COG4483	Protein conserved in bacteria
ISP08_RS06495	COG1940	carbohydrate kinase activity
ISP08_RS06500	COG0011	TIGRFAM Protein of
ISP08_RS06505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ISP08_RS06510	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ISP08_RS06540	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ISP08_RS06545	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ISP08_RS06550	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ISP08_RS06555	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ISP08_RS06560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ISP08_RS06565	COG0095	Lipoate-protein ligase
ISP08_RS06580	COG0006	proline dipeptidase activity
ISP08_RS06585	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ISP08_RS06590	COG0511	ligase activity, forming carbon-carbon bonds
ISP08_RS06595	COG0439	Biotin carboxylase
ISP08_RS06605	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ISP08_RS06610	COG1570	exodeoxyribonuclease VII activity
ISP08_RS06625	COG1438	arginine binding
ISP08_RS06630	COG0497	DNA recombination
ISP08_RS06635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ISP08_RS06640	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ISP08_RS06645	COG0022	dehydrogenase e1 component
ISP08_RS06650	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISP08_RS06660	COG4129	membrane
ISP08_RS06670	COG2195	Cleaves the N-terminal amino acid of tripeptides
ISP08_RS06680	COG0366	Alpha amylase catalytic
ISP08_RS06695	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ISP08_RS06700	COG1234	tRNA 3'-trailer cleavage
ISP08_RS06705	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ISP08_RS06715	COG0667	Aldo Keto reductase
ISP08_RS06720	COG0494	nUDIX hydrolase
ISP08_RS06725	COG0735	belongs to the Fur family
ISP08_RS06730	COG4974	Belongs to the 'phage' integrase family
ISP08_RS06740	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ISP08_RS06745	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ISP08_RS06750	COG1187	pseudouridine synthase activity
ISP08_RS06755	COG0745	RESPONSE REGULATOR receiver
ISP08_RS06770	COG1141	Ferredoxin
ISP08_RS06780	COG0514	ATP-dependent DNA helicase (RecQ)
ISP08_RS06785	COG1388	LysM domain
ISP08_RS06785	COG1388	LysM domain
ISP08_RS06790	COG0492	ferredoxin-NADP+ reductase activity
ISP08_RS06795	COG0252	asparaginase activity
ISP08_RS06800	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ISP08_RS06805	COG0539	negative regulation of cytoplasmic translation
ISP08_RS06810	COG1160	GTP binding
ISP08_RS06815	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ISP08_RS06830	COG2226	methyltransferase
ISP08_RS06835	COG0142	geranyltranstransferase activity
ISP08_RS06840	COG0105	UTP biosynthetic process
ISP08_RS06845	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ISP08_RS06850	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ISP08_RS06855	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ISP08_RS06865	COG5582	Belongs to the UPF0302 family
ISP08_RS06870	COG4347	Protein of unknown function (DUF1405)
ISP08_RS06875	COG2738	Putative neutral zinc metallopeptidase
ISP08_RS06880	COG1694	Mazg nucleotide pyrophosphohydrolase
ISP08_RS06885	COG0438	transferase activity, transferring glycosyl groups
ISP08_RS06890	COG0617	tRNA 3'-terminal CCA addition
ISP08_RS06895	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ISP08_RS06895	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ISP08_RS06900	COG1199	ATP-dependent helicase activity
ISP08_RS06900	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ISP08_RS06905	COG0017	Asparaginyl-tRNA synthetase
ISP08_RS06910	COG3935	DnaD domain protein
ISP08_RS06915	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ISP08_RS06925	COG4499	WXG100 protein secretion system (Wss), protein YukC
ISP08_RS06925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ISP08_RS06930	COG3331	DNA recombination
ISP08_RS06940	COG4474	Belongs to the UPF0398 family
ISP08_RS06955	COG0116	Belongs to the methyltransferase superfamily
ISP08_RS06960	COG2962	Rard protein
ISP08_RS06970	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ISP08_RS06975	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ISP08_RS06990	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ISP08_RS07000	COG1413	lyase activity
ISP08_RS07010	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ISP08_RS07030	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ISP08_RS07045	COG0793	Belongs to the peptidase S41A family
ISP08_RS07055	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ISP08_RS07060	COG0671	phosphoesterase, PA-phosphatase related
ISP08_RS07065	COG0745	RESPONSE REGULATOR receiver
ISP08_RS07070	COG5002	protein histidine kinase activity
ISP08_RS07075	COG0567	Dehydrogenase, E1 component
ISP08_RS07080	COG0508	dehydrogenase complex catalyzes the overall conversion of
ISP08_RS07110	COG0714	Associated with various cellular activities
ISP08_RS07115	COG4548	von Willebrand factor, type A
ISP08_RS07120	COG1114	Component of the transport system for branched-chain amino acids
ISP08_RS07125	COG3853	Toxic anion resistance protein (TelA)
ISP08_RS07135	COG1254	Belongs to the acylphosphatase family
ISP08_RS07145	COG1278	Cold shock
ISP08_RS07160	COG1473	amidohydrolase
ISP08_RS07165	COG2171	N-acyltransferase activity
ISP08_RS07170	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ISP08_RS07175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ISP08_RS07180	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ISP08_RS07185	COG0527	aspartate kinase activity
ISP08_RS07195	COG0488	(ABC) transporter
ISP08_RS07200	COG2996	Protein conserved in bacteria
ISP08_RS07205	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ISP08_RS07210	COG0573	inorganic phosphate transmembrane transporter activity
ISP08_RS07215	COG0581	inorganic phosphate transmembrane transporter activity
ISP08_RS07220	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ISP08_RS07225	COG0704	Plays a role in the regulation of phosphate uptake
ISP08_RS07230	COG1164	Oligoendopeptidase f
ISP08_RS07240	COG4607	ABC-type enterochelin transport system periplasmic component
ISP08_RS07250	COG2348	transferase activity, transferring amino-acyl groups
ISP08_RS07260	COG0159	tryptophan synthase activity
ISP08_RS07275	COG0134	indole-3-glycerol-phosphate synthase activity
ISP08_RS07280	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ISP08_RS07285	COG0512	Glutamine amidotransferase of anthranilate synthase
ISP08_RS07290	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ISP08_RS07295	COG1363	Peptidase, m42
ISP08_RS07300	COG0287	Prephenate dehydrogenase
ISP08_RS07305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ISP08_RS07310	COG2169	Transcriptional regulator
ISP08_RS07315	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ISP08_RS07320	COG1942	4-Oxalocrotonate Tautomerase
ISP08_RS07335	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ISP08_RS07335	COG0392	lysyltransferase activity
ISP08_RS07340	COG0628	permease
ISP08_RS07345	COG3711	transcriptional antiterminator
ISP08_RS07350	COG1115	amino acid carrier protein
ISP08_RS07355	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ISP08_RS07365	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ISP08_RS07370	COG4841	protein insertion into membrane
ISP08_RS07380	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ISP08_RS07385	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ISP08_RS07390	COG1970	mechanosensitive ion channel activity
ISP08_RS07395	COG0419	ATPase involved in DNA repair
ISP08_RS07400	COG0420	3'-5' exonuclease activity
ISP08_RS07405	COG4846	Membrane protein involved in cytochrome C biogenesis
ISP08_RS07420	COG3763	UPF0154 protein
ISP08_RS07440	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ISP08_RS07445	COG2340	Cysteine-rich secretory protein family
ISP08_RS07450	COG0516	GMP reductase activity
ISP08_RS07455	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ISP08_RS07460	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ISP08_RS07465	COG0753	catalase activity
ISP08_RS07470	COG0833	amino acid
ISP08_RS07480	COG0561	phosphatase activity
ISP08_RS07485	COG0083	homoserine kinase activity
ISP08_RS07490	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ISP08_RS07495	COG0460	homoserine dehydrogenase
ISP08_RS07500	COG0527	aspartate kinase activity
ISP08_RS07520	COG1525	nuclease
ISP08_RS07535	COG2197	response regulator
ISP08_RS07540	COG4585	Histidine kinase
ISP08_RS07545	COG0842	Transport permease protein
ISP08_RS07550	COG1131	(ABC) transporter
ISP08_RS07565	COG0789	Transcriptional regulator
ISP08_RS07570	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
ISP08_RS07575	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ISP08_RS07580	COG0386	Belongs to the glutathione peroxidase family
ISP08_RS07585	COG1923	regulation of RNA biosynthetic process
ISP08_RS07590	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ISP08_RS07600	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ISP08_RS07605	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ISP08_RS07610	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ISP08_RS07615	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
ISP08_RS07620	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ISP08_RS07625	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ISP08_RS07635	COG4550	Control of competence regulator ComK, YlbF/YmcA
ISP08_RS07640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ISP08_RS07655	COG1013	pyruvate-flavodoxin oxidoreductase activity
ISP08_RS07660	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ISP08_RS07660	COG0674	pyruvate-flavodoxin oxidoreductase activity
ISP08_RS07665	COG1692	metallophosphoesterase
ISP08_RS07675	COG1418	mRNA catabolic process
ISP08_RS07680	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ISP08_RS07685	COG1058	Belongs to the CinA family
ISP08_RS07685	COG1546	Belongs to the CinA family
ISP08_RS07705	COG0300	oxidoreductase activity
ISP08_RS07710	COG0612	Peptidase, M16
ISP08_RS07715	COG0612	Peptidase, M16
ISP08_RS07720	COG2188	Transcriptional regulator
ISP08_RS07725	COG1674	ftsk spoiiie
ISP08_RS07730	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ISP08_RS07735	COG1185	polyribonucleotide nucleotidyltransferase activity
ISP08_RS07740	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ISP08_RS07745	COG0196	riboflavin kinase activity
ISP08_RS07750	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ISP08_RS07755	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ISP08_RS07770	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ISP08_RS07775	COG1358	cellular component organization or biogenesis
ISP08_RS07780	COG2740	Nucleic-acid-binding protein implicated in transcription termination
ISP08_RS07785	COG0195	Participates in both transcription termination and antitermination
ISP08_RS07790	COG0779	Required for maturation of 30S ribosomal subunits
ISP08_RS07795	COG2176	DNA-directed DNA polymerase activity
ISP08_RS07800	COG0442	prolyl-tRNA aminoacylation
ISP08_RS07810	COG4589	Belongs to the CDS family
ISP08_RS07815	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ISP08_RS07820	COG0233	cytoplasmic translational termination
ISP08_RS07825	COG0528	UMP kinase activity
ISP08_RS07830	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ISP08_RS07835	COG0052	Belongs to the universal ribosomal protein uS2 family
ISP08_RS07840	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ISP08_RS07845	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ISP08_RS07850	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ISP08_RS07855	COG4974	Belongs to the 'phage' integrase family
ISP08_RS07860	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ISP08_RS07865	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ISP08_RS07870	COG0758	DNA mediated transformation
ISP08_RS07875	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ISP08_RS07880	COG0045	succinate-CoA ligase (ADP-forming) activity
ISP08_RS07885	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ISP08_RS07895	COG4485	Bacterial membrane protein, YfhO
ISP08_RS07910	COG0336	Belongs to the RNA methyltransferase TrmD family
ISP08_RS07915	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ISP08_RS07920	COG0228	four-way junction DNA binding
ISP08_RS07925	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ISP08_RS07930	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
ISP08_RS07935	COG0552	protein localization to endoplasmic reticulum
ISP08_RS07940	COG1196	nuclear chromosome segregation
ISP08_RS07945	COG0571	ribonuclease III activity
ISP08_RS07950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISP08_RS07965	COG0416	fatty acid biosynthetic process
ISP08_RS07970	COG1349	DNA-binding transcription factor activity
ISP08_RS07985	COG1760	l-serine dehydratase
ISP08_RS07990	COG1760	l-serine dehydratase
ISP08_RS07995	COG1461	Dihydroxyacetone kinase
ISP08_RS08000	COG1302	Protein conserved in bacteria
ISP08_RS08005	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ISP08_RS08010	COG1564	THIamine pyrophosphokinase
ISP08_RS08015	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ISP08_RS08020	COG1162	GTPase activity
ISP08_RS08030	COG0631	protein serine/threonine phosphatase activity
ISP08_RS08035	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ISP08_RS08040	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ISP08_RS08040	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ISP08_RS08045	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ISP08_RS08065	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ISP08_RS08070	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ISP08_RS08075	COG1758	RNA polymerase activity
ISP08_RS08080	COG0194	GDP metabolic process
ISP08_RS08085	COG1293	RNA-binding protein homologous to eukaryotic snRNP
ISP08_RS08095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ISP08_RS08105	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ISP08_RS08110	COG0284	orotidine-5'-phosphate decarboxylase activity
ISP08_RS08115	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ISP08_RS08120	COG0505	Belongs to the CarA family
ISP08_RS08130	COG0540	Belongs to the ATCase OTCase family
ISP08_RS08140	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ISP08_RS08145	COG0564	pseudouridine synthase activity
ISP08_RS08155	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ISP08_RS08160	COG3599	regulation of cell shape
ISP08_RS08170	COG0762	integral membrane protein
ISP08_RS08175	COG1799	cell septum assembly
ISP08_RS08180	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ISP08_RS08185	COG1496	oxidoreductase activity
ISP08_RS08190	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ISP08_RS08195	COG0849	cell division
ISP08_RS08205	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ISP08_RS08210	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ISP08_RS08215	COG0768	penicillin binding
ISP08_RS08220	COG4839	cell division protein FtsL
ISP08_RS08225	COG0275	rRNA processing
ISP08_RS08230	COG2001	Belongs to the MraZ family
ISP08_RS08235	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
ISP08_RS08240	COG0454	-acetyltransferase
ISP08_RS08245	COG1011	Hydrolase
ISP08_RS08275	COG0693	protein deglycase activity
ISP08_RS08300	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ISP08_RS08305	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ISP08_RS08310	COG1053	succinate dehydrogenase
ISP08_RS08315	COG2009	succinate dehydrogenase
ISP08_RS08320	COG0322	excinuclease ABC activity
ISP08_RS08325	COG3118	belongs to the thioredoxin family
ISP08_RS08330	COG1193	negative regulation of DNA recombination
ISP08_RS08335	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ISP08_RS08335	COG1796	DNA polymerase
ISP08_RS08345	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ISP08_RS08350	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ISP08_RS08355	COG0072	phenylalanine-tRNA ligase activity
ISP08_RS08360	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ISP08_RS08365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISP08_RS08370	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ISP08_RS08380	COG1323	Belongs to the UPF0348 family
ISP08_RS08385	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ISP08_RS08390	COG0742	ribosomal rna small subunit methyltransferase
ISP08_RS08400	COG4471	UPF0298 protein
ISP08_RS08405	COG0584	glycerophosphoryl diester phosphodiesterase
ISP08_RS08410	COG3679	Belongs to the UPF0342 family
ISP08_RS08420	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ISP08_RS08430	COG0109	protoheme IX farnesyltransferase activity
ISP08_RS08435	COG1612	heme a metabolic process
ISP08_RS08445	COG0772	Belongs to the SEDS family
ISP08_RS08450	COG4838	Belongs to the UPF0358 family
ISP08_RS08455	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ISP08_RS08460	COG4896	Protein conserved in bacteria
ISP08_RS08465	COG1217	gtp-binding protein TYPA
ISP08_RS08475	COG0483	inositol monophosphate 1-phosphatase activity
ISP08_RS08480	COG4493	Belongs to the UPF0637 family
ISP08_RS08490	COG1914	H( )-stimulated, divalent metal cation uptake system
ISP08_RS08500	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ISP08_RS08505	COG1177	transmembrane transport
ISP08_RS08510	COG1176	ABC-type spermidine putrescine transport system, permease component I
ISP08_RS08515	COG3842	ATPase activity
ISP08_RS08525	COG4476	Belongs to the UPF0223 family
ISP08_RS08555	COG0242	peptide deformylase activity
ISP08_RS08565	COG5503	Protein of unknown function (DUF1447)
ISP08_RS08570	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ISP08_RS08575	COG0569	domain protein
ISP08_RS08580	COG1294	oxidase, subunit
ISP08_RS08585	COG1271	oxidase subunit
ISP08_RS08595	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ISP08_RS08600	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISP08_RS08610	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ISP08_RS08630	COG4172	Belongs to the ABC transporter superfamily
ISP08_RS08635	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ISP08_RS08645	COG0138	bifunctional purine biosynthesis protein purh
ISP08_RS08655	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ISP08_RS08665	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ISP08_RS08670	COG0047	phosphoribosylformylglycinamidine synthase activity
ISP08_RS08675	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ISP08_RS08680	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ISP08_RS08685	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ISP08_RS08690	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ISP08_RS08695	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ISP08_RS08705	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ISP08_RS08715	COG1845	cytochrome c oxidase, subunit III
ISP08_RS08720	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ISP08_RS08730	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ISP08_RS08735	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ISP08_RS08740	COG1316	TRANSCRIPTIONal
ISP08_RS08765	COG3594	Acyltransferase
ISP08_RS08770	COG0436	Aminotransferase
ISP08_RS08780	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ISP08_RS08790	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ISP08_RS08795	COG1169	isochorismate synthase
ISP08_RS08800	COG1575	Belongs to the MenA family. Type 1 subfamily
ISP08_RS08830	COG4903	ComK protein
ISP08_RS08845	COG4873	Protein conserved in bacteria
ISP08_RS08855	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ISP08_RS08860	COG0737	Belongs to the 5'-nucleotidase family
ISP08_RS08865	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ISP08_RS08870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ISP08_RS08875	COG0861	Integral membrane protein TerC family
ISP08_RS08880	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ISP08_RS08890	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ISP08_RS08895	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ISP08_RS08900	COG2814	Major facilitator Superfamily
ISP08_RS08905	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ISP08_RS08910	COG2382	esterase
ISP08_RS08915	COG1115	amino acid carrier protein
ISP08_RS08920	COG0628	permease
ISP08_RS08935	COG0569	domain protein
ISP08_RS08935	COG0475	glutathione-regulated potassium exporter activity
ISP08_RS08940	COG2239	Acts as a magnesium transporter
ISP08_RS08945	COG0564	pseudouridine synthase activity
ISP08_RS08950	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ISP08_RS08955	COG2357	RelA SpoT domain protein
ISP08_RS08965	COG4116	CYTH
ISP08_RS08970	COG2346	COG2346, Truncated hemoglobins
ISP08_RS08975	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ISP08_RS08980	COG1164	Oligoendopeptidase f
ISP08_RS09000	COG1393	Belongs to the ArsC family
ISP08_RS09005	COG0180	Tryptophanyl-tRNA synthetase
ISP08_RS09010	COG4166	transmembrane transport
ISP08_RS09015	COG4608	Belongs to the ABC transporter superfamily
ISP08_RS09020	COG0444	Belongs to the ABC transporter superfamily
ISP08_RS09025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ISP08_RS09030	COG0601	transmembrane transport
ISP08_RS09050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ISP08_RS09075	COG0561	phosphatase activity
ISP08_RS09080	COG0446	pyridine nucleotide-disulphide oxidoreductase
ISP08_RS09090	COG0179	Fumarylacetoacetate (FAA) hydrolase
ISP08_RS09095	COG1074	ATP-dependent DNA helicase activity
ISP08_RS09100	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ISP08_RS09115	COG0398	Pfam SNARE associated Golgi protein
ISP08_RS09120	COG0166	Belongs to the GPI family
ISP08_RS09125	COG0137	argininosuccinate synthase activity
ISP08_RS09130	COG0165	Argininosuccinate lyase
ISP08_RS09140	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ISP08_RS09145	COG1902	pentaerythritol trinitrate reductase activity
ISP08_RS09150	COG1098	S1 RNA binding domain
ISP08_RS09155	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ISP08_RS09165	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ISP08_RS09165	COG2111	Na H antiporter
ISP08_RS09170	COG2111	Na H antiporter
ISP08_RS09175	COG1006	Multisubunit Na H antiporter MnhC subunit
ISP08_RS09180	COG0651	ATP synthesis coupled electron transport
ISP08_RS09185	COG1863	multisubunit Na H antiporter MnhE subunit
ISP08_RS09190	COG2212	antiporter activity
ISP08_RS09195	COG1320	monovalent cation:proton antiporter activity
ISP08_RS09205	COG2050	protein possibly involved in aromatic compounds catabolism
ISP08_RS09210	COG2056	Na+-H+ antiporter family
ISP08_RS09215	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ISP08_RS09220	COG1252	NADH dehydrogenase
ISP08_RS09225	COG0316	Belongs to the HesB IscA family
ISP08_RS09230	COG4844	belongs to the
ISP08_RS09235	COG1252	NADH dehydrogenase
ISP08_RS09240	COG4837	Protein of unknown function (DUF1462)
ISP08_RS09245	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ISP08_RS09250	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
ISP08_RS09255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ISP08_RS09260	COG1696	Membrane protein involved in D-alanine export
ISP08_RS09265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ISP08_RS09275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ISP08_RS09280	COG0647	UMP catabolic process
ISP08_RS09285	COG2445	Protein of unknown function DUF86
ISP08_RS09295	COG4470	Protein conserved in bacteria
ISP08_RS09305	COG0737	Belongs to the 5'-nucleotidase family
ISP08_RS09310	COG1801	Protein of unknown function DUF72
ISP08_RS09320	COG0719	Fe-S assembly protein
ISP08_RS09325	COG0822	iron-sulfur transferase activity
ISP08_RS09330	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ISP08_RS09335	COG0719	Fe-S assembly protein
ISP08_RS09340	COG0396	ATPase activity
ISP08_RS09345	COG1464	Belongs to the NlpA lipoprotein family
ISP08_RS09350	COG2011	ABC-type metal ion transport system permease component
ISP08_RS09355	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISP08_RS09365	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ISP08_RS09370	COG0509	glycine decarboxylation via glycine cleavage system
ISP08_RS09375	COG1393	Belongs to the ArsC family
ISP08_RS09380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ISP08_RS09390	COG0710	3-dehydroquinate dehydratase activity
ISP08_RS09395	COG1764	response to oxidative stress
ISP08_RS09410	COG2851	Citrate transporter
ISP08_RS09425	COG2314	TM2 domain
ISP08_RS09465	COG0561	phosphatase activity
ISP08_RS09480	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ISP08_RS09530	COG1388	LysM domain
ISP08_RS09530	COG5632	N-Acetylmuramoyl-L-alanine amidase
ISP08_RS09590	COG5280	Phage tail tape measure protein TP901
ISP08_RS09590	COG3953	SLT domain
ISP08_RS09805	COG3620	sequence-specific DNA binding
ISP08_RS09855	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ISP08_RS09860	COG0557	exoribonuclease II activity
ISP08_RS09865	COG1647	Serine aminopeptidase, S33
ISP08_RS09870	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ISP08_RS09880	COG0148	phosphopyruvate hydratase activity
ISP08_RS09885	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ISP08_RS09890	COG0149	triose-phosphate isomerase activity
ISP08_RS09895	COG0126	phosphoglycerate kinase activity
ISP08_RS09925	COG1090	epimerase
ISP08_RS09930	COG0740	serine-type endopeptidase activity
ISP08_RS09945	COG1481	regulation of sporulation
ISP08_RS09950	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ISP08_RS09955	COG1660	Displays ATPase and GTPase activities
ISP08_RS09960	COG0492	ferredoxin-NADP+ reductase activity
ISP08_RS09970	COG0110	maltose O-acetyltransferase activity
ISP08_RS09975	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ISP08_RS09980	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ISP08_RS09985	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ISP08_RS09990	COG0556	nucleotide-excision repair
ISP08_RS10005	COG3942	CHAP domain
ISP08_RS10005	COG1388	LysM domain
ISP08_RS10015	COG0653	protein targeting
ISP08_RS10020	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ISP08_RS10025	COG1040	competence protein
ISP08_RS10030	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
ISP08_RS10040	COG1739	Uncharacterized protein family UPF0029
ISP08_RS10045	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ISP08_RS10050	COG2199	diguanylate cyclase activity
ISP08_RS10065	COG2195	Cleaves the N-terminal amino acid of tripeptides
ISP08_RS10070	COG1929	Belongs to the glycerate kinase type-1 family
ISP08_RS10090	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ISP08_RS10100	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISP08_RS10105	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ISP08_RS10110	COG1780	Probably involved in ribonucleotide reductase function
ISP08_RS10120	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ISP08_RS10125	COG3104	oligopeptide transport
ISP08_RS10130	COG3104	oligopeptide transport
ISP08_RS10135	COG1597	lipid kinase activity
ISP08_RS10145	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ISP08_RS10150	COG1174	glycine betaine transport
ISP08_RS10155	COG0517	IMP dehydrogenase activity
ISP08_RS10155	COG1125	glycine betaine transport
ISP08_RS10160	COG0514	ATP-dependent DNA helicase (RecQ)
ISP08_RS10165	COG0488	(ABC) transporter
ISP08_RS10170	COG1368	sulfuric ester hydrolase activity
ISP08_RS10180	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ISP08_RS10190	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ISP08_RS10190	COG0512	Glutamine amidotransferase of anthranilate synthase
ISP08_RS10195	COG0512	Glutamine amidotransferase of anthranilate synthase
ISP08_RS10200	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ISP08_RS10205	COG0720	synthase
ISP08_RS10210	COG0602	queuosine metabolic process
ISP08_RS10225	COG0463	Glycosyl transferase, family 2
ISP08_RS10230	COG0656	L-ascorbic acid biosynthetic process
ISP08_RS10235	COG1253	flavin adenine dinucleotide binding
ISP08_RS10240	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISP08_RS10240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISP08_RS10240	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISP08_RS10245	COG1105	Belongs to the carbohydrate kinase PfkB family
ISP08_RS10250	COG1349	DNA-binding transcription factor activity
ISP08_RS10255	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ISP08_RS10260	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ISP08_RS10290	COG0586	Pfam SNARE associated Golgi protein
ISP08_RS10300	COG4989	oxidoreductase activity
ISP08_RS10305	COG0523	cobalamin synthesis protein
ISP08_RS10320	COG4988	ABC transporter
ISP08_RS10325	COG1968	undecaprenyl-diphosphatase activity
ISP08_RS10335	COG1671	Belongs to the UPF0178 family
ISP08_RS10370	COG2814	Major facilitator Superfamily
ISP08_RS10375	COG2839	Protein conserved in bacteria
ISP08_RS10380	COG2814	Major facilitator Superfamily
ISP08_RS10385	COG0583	DNA-binding transcription factor activity
ISP08_RS10395	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ISP08_RS10405	COG0217	transcriptional regulatory protein
ISP08_RS10415	COG1388	LysM domain
ISP08_RS10415	COG3942	CHAP domain
ISP08_RS10420	COG0306	phosphate transporter
ISP08_RS10425	COG1392	Phosphate transport regulator
ISP08_RS10430	COG2205	protein histidine kinase activity
ISP08_RS10435	COG0745	RESPONSE REGULATOR receiver
ISP08_RS10440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISP08_RS10465	COG1461	Dihydroxyacetone kinase
ISP08_RS10470	COG2376	Dihydroxyacetone kinase
ISP08_RS10475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISP08_RS10480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISP08_RS10485	COG1120	ATPase activity
ISP08_RS10490	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ISP08_RS10495	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISP08_RS10500	COG1132	(ABC) transporter
ISP08_RS10510	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ISP08_RS10520	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ISP08_RS10525	COG1682	transport, permease protein
ISP08_RS10530	COG1134	teichoic acid transport
ISP08_RS10540	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
ISP08_RS10555	COG1121	(ABC) transporter
ISP08_RS10560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ISP08_RS10565	COG0803	Belongs to the bacterial solute-binding protein 9 family
ISP08_RS10575	COG1320	monovalent cation:proton antiporter activity
ISP08_RS10580	COG2212	antiporter activity
ISP08_RS10585	COG1863	multisubunit Na H antiporter MnhE subunit
ISP08_RS10590	COG0651	ATP synthesis coupled electron transport
ISP08_RS10595	COG1006	Multisubunit Na H antiporter MnhC subunit
ISP08_RS10600	COG2111	Na H antiporter
ISP08_RS10605	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ISP08_RS10605	COG2111	Na H antiporter
ISP08_RS10610	COG4974	Belongs to the 'phage' integrase family
ISP08_RS10640	COG2267	carboxylic ester hydrolase activity
ISP08_RS10660	COG0546	phosphoglycolate phosphatase activity
ISP08_RS10665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ISP08_RS10670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ISP08_RS10680	COG0789	Transcriptional regulator
ISP08_RS10680	COG4978	Transcriptional regulator
ISP08_RS10690	COG0018	arginyl-trna synthetase
ISP08_RS10705	COG1078	dGTPase activity
ISP08_RS10715	COG0655	NAD(P)H dehydrogenase (quinone) activity
ISP08_RS10720	COG0667	Aldo Keto reductase
ISP08_RS10725	COG4844	belongs to the
ISP08_RS10735	COG0673	inositol 2-dehydrogenase activity
ISP08_RS10745	COG0673	inositol 2-dehydrogenase activity
ISP08_RS10750	COG1737	Transcriptional regulator
ISP08_RS10765	COG0083	homoserine kinase activity
ISP08_RS10770	COG0095	Lipoate-protein ligase
ISP08_RS10775	COG0280	phosphate acetyltransferase
ISP08_RS10780	COG3253	May function as heme-dependent peroxidase
ISP08_RS10795	COG0477	Major facilitator Superfamily
ISP08_RS10810	COG2363	Small membrane protein
ISP08_RS10820	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ISP08_RS10835	COG0039	L-malate dehydrogenase activity
ISP08_RS10845	COG2211	Major facilitator Superfamily
ISP08_RS10865	COG0183	Belongs to the thiolase family
ISP08_RS10870	COG0318	PFAM AMP-dependent synthetase and ligase
ISP08_RS10880	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ISP08_RS10885	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ISP08_RS10890	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ISP08_RS10905	COG0431	NADPH-dependent FMN reductase
ISP08_RS10910	COG0561	phosphatase activity
ISP08_RS10920	COG1428	Deoxynucleoside kinase
ISP08_RS10925	COG1428	Deoxynucleoside kinase
ISP08_RS10940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ISP08_RS10945	COG1942	4-Oxalocrotonate Tautomerase
ISP08_RS10950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ISP08_RS10955	COG0667	Aldo Keto reductase
ISP08_RS10960	COG2814	Major facilitator Superfamily
ISP08_RS10970	COG0583	DNA-binding transcription factor activity
ISP08_RS10975	COG2814	Major facilitator Superfamily
ISP08_RS10985	COG1113	amino acid transport
ISP08_RS10990	COG0010	Belongs to the arginase family
ISP08_RS10995	COG1914	H( )-stimulated, divalent metal cation uptake system
ISP08_RS11000	COG1069	ribulokinase activity
ISP08_RS11005	COG2814	Major facilitator Superfamily
ISP08_RS11010	COG1349	DNA-binding transcription factor activity
ISP08_RS11015	COG2814	Major facilitator Superfamily
ISP08_RS11020	COG1733	regulation of RNA biosynthetic process
ISP08_RS11025	COG1028	Short-chain dehydrogenase reductase Sdr
ISP08_RS11030	COG1312	Catalyzes the dehydration of D-mannonate
ISP08_RS11035	COG1904	glucuronate isomerase
ISP08_RS11045	COG0800	Aldolase
ISP08_RS11050	COG1609	Transcriptional regulator
ISP08_RS11060	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ISP08_RS11075	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ISP08_RS11080	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ISP08_RS11110	COG1473	amidohydrolase
ISP08_RS11115	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ISP08_RS11120	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ISP08_RS11125	COG0049	tRNA binding
ISP08_RS11140	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ISP08_RS11145	COG0085	RNA polymerase activity
ISP08_RS11150	COG2813	Specifically methylates the guanine in position
ISP08_RS11160	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ISP08_RS11165	COG0081	regulation of translation
ISP08_RS11170	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ISP08_RS11175	COG0250	Participates in transcription elongation, termination and antitermination
ISP08_RS11185	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ISP08_RS11200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ISP08_RS11205	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
ISP08_RS11210	COG0215	cysteine-tRNA ligase activity
ISP08_RS11215	COG1045	serine acetyltransferase
ISP08_RS11220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ISP08_RS11225	COG4956	integral membrane protein (PIN domain superfamily)
ISP08_RS11230	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ISP08_RS11235	COG0542	response to heat
ISP08_RS11240	COG3869	Catalyzes the specific phosphorylation of arginine residues in
ISP08_RS11245	COG3880	PFAM UvrB UvrC protein
ISP08_RS11250	COG4463	regulation of RNA biosynthetic process
ISP08_RS11255	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ISP08_RS11260	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ISP08_RS11265	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ISP08_RS11270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ISP08_RS11355	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ISP08_RS11360	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ISP08_RS11375	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ISP08_RS11380	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ISP08_RS11385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ISP08_RS11400	COG1098	S1 RNA binding domain
ISP08_RS11410	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ISP08_RS11415	COG3956	TIGRFAM MazG family protein
ISP08_RS11420	COG2244	polysaccharide biosynthetic process
ISP08_RS11425	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ISP08_RS11430	COG0193	aminoacyl-tRNA hydrolase activity
ISP08_RS11435	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ISP08_RS11440	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ISP08_RS11445	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ISP08_RS11450	COG2088	sporulation resulting in formation of a cellular spore
ISP08_RS11455	COG0251	oxidation-reduction process
ISP08_RS11460	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ISP08_RS11465	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ISP08_RS11470	COG4466	Protein conserved in bacteria
ISP08_RS11475	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ISP08_RS11480	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ISP08_RS11485	COG0084	hydrolase, TatD family'
ISP08_RS11490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ISP08_RS11490	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ISP08_RS11495	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ISP08_RS11500	COG2827	Endonuclease containing a URI domain
ISP08_RS11505	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ISP08_RS11510	COG4467	Involved in initiation control of chromosome replication
ISP08_RS11515	COG1774	PSP1 C-terminal conserved region
ISP08_RS11520	COG0470	DNA polymerase III
ISP08_RS11525	COG3870	Protein conserved in bacteria
ISP08_RS11530	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ISP08_RS11535	COG1982	Orn Lys Arg decarboxylase major
ISP08_RS11555	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ISP08_RS11560	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ISP08_RS11565	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ISP08_RS11580	COG2188	Transcriptional regulator
ISP08_RS11585	COG0366	Alpha amylase catalytic
ISP08_RS11590	COG1263	PTS System
ISP08_RS11590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ISP08_RS11600	COG0493	'glutamate synthase
ISP08_RS11605	COG0070	glutamate synthase
ISP08_RS11605	COG0067	glutamate synthase
ISP08_RS11605	COG0069	glutamate synthase activity
ISP08_RS11625	COG0004	ammonium transporteR
ISP08_RS11645	COG3942	CHAP domain
ISP08_RS11645	COG1388	LysM domain
ISP08_RS11650	COG1464	Belongs to the NlpA lipoprotein family
ISP08_RS11655	COG2011	ABC-type metal ion transport system permease component
ISP08_RS11660	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ISP08_RS11675	COG0733	neurotransmitter:sodium symporter activity
ISP08_RS11705	COG1114	Component of the transport system for branched-chain amino acids
ISP08_RS11710	COG5646	InterPro IPR014922
ISP08_RS11725	COG2807	transmembrane transport
ISP08_RS11730	COG2814	Major facilitator Superfamily
ISP08_RS11770	COG2843	Capsule synthesis protein
ISP08_RS11790	COG2076	Multidrug Resistance protein
ISP08_RS11795	COG2076	Multidrug Resistance protein
ISP08_RS11800	COG1309	transcriptional regulator
ISP08_RS11805	COG0519	Catalyzes the synthesis of GMP from XMP
ISP08_RS11805	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ISP08_RS11810	COG0516	GMP reductase activity
ISP08_RS11810	COG0517	IMP dehydrogenase activity
ISP08_RS11815	COG2233	PERMEase
ISP08_RS11820	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ISP08_RS11840	COG1823	symporter activity
ISP08_RS11850	COG0778	Nitroreductase
ISP08_RS11855	COG0450	alkyl hydroperoxide reductase
ISP08_RS11895	COG5632	N-Acetylmuramoyl-L-alanine amidase
ISP08_RS11895	COG1388	LysM domain
ISP08_RS12115	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ISP08_RS12125	COG2076	Multidrug Resistance protein
ISP08_RS12130	COG2076	Multidrug Resistance protein
ISP08_RS12140	COG1764	response to oxidative stress
ISP08_RS12145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ISP08_RS12160	COG2814	Major facilitator Superfamily
ISP08_RS12165	COG0346	lactoylglutathione lyase activity
ISP08_RS12230	COG2843	Capsule synthesis protein
ISP08_RS12240	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ISP08_RS12305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ISP08_RS12315	COG1113	amino acid transport
ISP08_RS12325	COG1733	regulation of RNA biosynthetic process
ISP08_RS12330	COG1136	(ABC) transporter
ISP08_RS12330	COG0577	efflux transmembrane transporter activity
ISP08_RS12335	COG1136	(ABC) transporter
ISP08_RS12405	COG1785	Belongs to the alkaline phosphatase family
ISP08_RS12470	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ISP08_RS12480	COG0360	Binds together with S18 to 16S ribosomal RNA
ISP08_RS12500	COG0012	GTP binding
ISP08_RS12505	COG4481	Protein conserved in bacteria
ISP08_RS12510	COG0668	transmembrane transport
ISP08_RS12520	COG0604	alcohol dehydrogenase
ISP08_RS12530	COG0789	Transcriptional regulator
ISP08_RS12535	COG1028	Short-chain dehydrogenase reductase Sdr
ISP08_RS12540	COG0583	DNA-binding transcription factor activity
ISP08_RS12550	COG2814	Major facilitator Superfamily
ISP08_RS12555	COG3119	arylsulfatase activity
ISP08_RS12555	COG3408	Glycogen debranching enzyme
ISP08_RS12560	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ISP08_RS12575	COG1028	Short-chain dehydrogenase reductase Sdr
ISP08_RS12585	COG0596	Alpha beta hydrolase
ISP08_RS12635	COG1346	cytolysis
ISP08_RS12640	COG1028	Short-chain dehydrogenase reductase Sdr
ISP08_RS12645	COG1475	DNA binding
ISP08_RS12650	COG0626	cystathionine gamma-synthase activity
ISP08_RS12655	COG0626	cystathionine gamma-synthase activity
ISP08_RS12660	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ISP08_RS12660	COG0646	methionine synthase
ISP08_RS12665	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ISP08_RS12675	COG2314	TM2 domain
ISP08_RS12680	COG1966	Carbon starvation protein
ISP08_RS12685	COG2807	transmembrane transport
ISP08_RS12690	COG1476	TRANSCRIPTIONal
ISP08_RS12695	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ISP08_RS12700	COG0598	Magnesium transport protein CorA
ISP08_RS12710	COG2348	transferase activity, transferring amino-acyl groups
ISP08_RS12715	COG0191	fructose-bisphosphate aldolase activity
ISP08_RS12720	COG2610	gluconate transmembrane transporter activity
ISP08_RS12730	COG2084	Dehydrogenase
ISP08_RS12740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ISP08_RS12745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ISP08_RS12750	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISP08_RS12750	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISP08_RS12755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ISP08_RS12760	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ISP08_RS12770	COG3711	transcriptional antiterminator
ISP08_RS12775	COG2153	protein acetylation
ISP08_RS12785	COG1475	DNA binding
ISP08_RS12790	COG0357	Ribosomal RNA small subunit methyltransferase G
ISP08_RS12795	COG0445	tRNA wobble uridine modification
ISP08_RS12800	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ISP08_RS12805	COG0594	ribonuclease P activity