locus-tag	class	description
GZH82_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GZH82_RS00010	COG0592	DNA-directed DNA polymerase activity
GZH82_RS00015	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GZH82_RS00015	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GZH82_RS00020	COG2501	S4 domain
GZH82_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GZH82_RS00030	COG0187	DNA topoisomerase II activity
GZH82_RS00040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GZH82_RS00045	COG2986	histidine ammonia-lyase
GZH82_RS00055	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GZH82_RS00065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GZH82_RS00070	COG4241	membrane
GZH82_RS00075	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
GZH82_RS00080	COG0359	binds to the 23S rRNA
GZH82_RS00085	COG0305	Participates in initiation and elongation during chromosome replication
GZH82_RS00090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GZH82_RS00095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GZH82_RS00125	COG0745	RESPONSE REGULATOR receiver
GZH82_RS00130	COG5002	protein histidine kinase activity
GZH82_RS00135	COG4863	YycH protein
GZH82_RS00145	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GZH82_RS00150	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GZH82_RS00200	COG1260	myo-inositol-1-phosphate synthase
GZH82_RS00205	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
GZH82_RS00225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GZH82_RS00245	COG1051	belongs to the nudix hydrolase family
GZH82_RS00250	COG1484	DNA-dependent DNA replication
GZH82_RS00275	COG2311	Membrane
GZH82_RS00300	COG0531	amino acid
GZH82_RS00305	COG2217	Heavy metal translocating P-type atpase
GZH82_RS00325	COG4409	exo-alpha-(2->6)-sialidase activity
GZH82_RS00385	COG0454	-acetyltransferase
GZH82_RS00395	COG0201	protein transport
GZH82_RS00405	COG1073	alpha beta
GZH82_RS00455	COG0438	transferase activity, transferring glycosyl groups
GZH82_RS00480	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GZH82_RS00490	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GZH82_RS00505	COG3655	Transcriptional regulator
GZH82_RS00510	COG3177	Filamentation induced by cAMP protein fic
GZH82_RS00515	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GZH82_RS00540	COG0583	DNA-binding transcription factor activity
GZH82_RS00545	COG1288	antiporter activity
GZH82_RS00575	COG1012	belongs to the aldehyde dehydrogenase family
GZH82_RS00580	COG2205	protein histidine kinase activity
GZH82_RS00590	COG1131	(ABC) transporter
GZH82_RS00595	COG0745	RESPONSE REGULATOR receiver
GZH82_RS00610	COG1353	crispr-associated protein
GZH82_RS00615	COG1421	Csm2 Type III-A
GZH82_RS00620	COG1337	RAMP superfamily
GZH82_RS00625	COG1567	CRISPR-associated RAMP protein, Csm4 family
GZH82_RS00630	COG1332	CRISPR-associated RAMP protein, Csm5 family
GZH82_RS00670	COG1737	Transcriptional regulator
GZH82_RS00675	COG1263	PTS System
GZH82_RS00675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZH82_RS00680	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GZH82_RS00710	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GZH82_RS00730	COG1695	Transcriptional regulator
GZH82_RS00740	COG3477	response to acidic pH
GZH82_RS00760	COG3711	transcriptional antiterminator
GZH82_RS00775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GZH82_RS00795	COG2235	arginine
GZH82_RS00810	COG2197	response regulator
GZH82_RS00815	COG4585	Histidine kinase
GZH82_RS00815	COG2203	Gaf domain
GZH82_RS00820	COG0842	Transport permease protein
GZH82_RS00825	COG1131	(ABC) transporter
GZH82_RS00850	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GZH82_RS00850	COG4447	cellulose binding
GZH82_RS00865	COG0431	NADPH-dependent FMN reductase
GZH82_RS00895	COG2508	Transcriptional regulator
GZH82_RS00900	COG1953	Uracil, thiamine, allantoin
GZH82_RS00905	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GZH82_RS00920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GZH82_RS00925	COG3257	ureidoglycine aminohydrolase activity
GZH82_RS00930	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GZH82_RS00935	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GZH82_RS00940	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GZH82_RS00945	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GZH82_RS00960	COG2807	transmembrane transport
GZH82_RS00995	COG1609	Transcriptional regulator
GZH82_RS01005	COG0673	inositol 2-dehydrogenase activity
GZH82_RS01015	COG0366	Alpha amylase catalytic
GZH82_RS01025	COG3833	ABC-type maltose transport systems, permease component
GZH82_RS01030	COG1175	transmembrane transport
GZH82_RS01040	COG3842	ATPase activity
GZH82_RS01050	COG0490	domain, Protein
GZH82_RS01055	COG3592	Divergent 4Fe-4S mono-cluster
GZH82_RS01060	COG0346	lactoylglutathione lyase activity
GZH82_RS01070	COG0366	Alpha amylase catalytic
GZH82_RS01075	COG2188	Transcriptional regulator
GZH82_RS01080	COG2222	sugar isomerase
GZH82_RS01085	COG1105	Belongs to the carbohydrate kinase PfkB family
GZH82_RS01100	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZH82_RS01100	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZH82_RS01105	COG3715	PTS system
GZH82_RS01110	COG3716	PTS system mannose fructose sorbose family IID component
GZH82_RS01120	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GZH82_RS01160	COG1063	alcohol dehydrogenase
GZH82_RS01165	COG1620	l-lactate permease
GZH82_RS01170	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GZH82_RS01175	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GZH82_RS01180	COG0156	8-amino-7-oxononanoate synthase activity
GZH82_RS01200	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GZH82_RS01210	COG2910	NAD(P)H-binding
GZH82_RS01215	COG2814	Major facilitator Superfamily
GZH82_RS01220	COG1335	isochorismatase
GZH82_RS01225	COG1309	transcriptional regulator
GZH82_RS01235	COG0076	glutamate decarboxylase activity
GZH82_RS01250	COG2318	DinB family
GZH82_RS01255	COG0753	catalase activity
GZH82_RS01265	COG0783	Belongs to the Dps family
GZH82_RS01280	COG0436	Aminotransferase
GZH82_RS01345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GZH82_RS01360	COG2814	Major facilitator Superfamily
GZH82_RS01395	COG0431	NADPH-dependent FMN reductase
GZH82_RS01400	COG1755	Isoprenylcysteine carboxyl methyltransferase
GZH82_RS01405	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GZH82_RS01415	COG0579	oxidoreductase
GZH82_RS01520	COG1073	alpha beta
GZH82_RS01535	COG0438	transferase activity, transferring glycosyl groups
GZH82_RS01540	COG0438	transferase activity, transferring glycosyl groups
GZH82_RS01550	COG2814	Major facilitator Superfamily
GZH82_RS01555	COG1960	acyl-CoA dehydrogenase activity
GZH82_RS01560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GZH82_RS01570	COG1116	anion transmembrane transporter activity
GZH82_RS01590	COG1609	Transcriptional regulator
GZH82_RS01595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GZH82_RS01600	COG1869	D-ribose catabolic process
GZH82_RS01605	COG1129	ABC transporter
GZH82_RS01610	COG1172	Belongs to the binding-protein-dependent transport system permease family
GZH82_RS01615	COG1879	ABC-type sugar transport system periplasmic component
GZH82_RS01620	COG2409	Drug exporters of the RND superfamily
GZH82_RS01655	COG3711	transcriptional antiterminator
GZH82_RS01660	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZH82_RS01670	COG3037	sugar-specific permease SgaT UlaA
GZH82_RS01695	COG1328	CTP reductase activity
GZH82_RS01700	COG0602	queuosine metabolic process
GZH82_RS01715	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GZH82_RS01720	COG1942	4-Oxalocrotonate Tautomerase
GZH82_RS01735	COG3443	Belongs to the bacterial solute-binding protein 9 family
GZH82_RS01735	COG0803	Belongs to the bacterial solute-binding protein 9 family
GZH82_RS01750	COG1349	DNA-binding transcription factor activity
GZH82_RS01755	COG1012	belongs to the aldehyde dehydrogenase family
GZH82_RS01765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GZH82_RS01770	COG3962	Belongs to the TPP enzyme family
GZH82_RS01775	COG0673	inositol 2-dehydrogenase activity
GZH82_RS01780	COG1082	Xylose isomerase domain protein TIM barrel
GZH82_RS01785	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GZH82_RS01790	COG0673	inositol 2-dehydrogenase activity
GZH82_RS01795	COG0191	fructose-bisphosphate aldolase activity
GZH82_RS01820	COG2972	Histidine kinase
GZH82_RS01830	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GZH82_RS01835	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
GZH82_RS01840	COG0477	Major facilitator Superfamily
GZH82_RS01855	COG2211	Major facilitator Superfamily
GZH82_RS01860	COG3250	beta-galactosidase activity
GZH82_RS01865	COG1957	nucleoside hydrolase
GZH82_RS01880	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GZH82_RS01885	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
GZH82_RS01890	COG2807	transmembrane transport
GZH82_RS01895	COG1476	TRANSCRIPTIONal
GZH82_RS01915	COG1785	Belongs to the alkaline phosphatase family
GZH82_RS01920	COG0494	nUDIX hydrolase
GZH82_RS01925	COG0556	nucleotide-excision repair
GZH82_RS01930	COG1914	H( )-stimulated, divalent metal cation uptake system
GZH82_RS01940	COG1510	regulation of RNA biosynthetic process
GZH82_RS01945	COG1012	belongs to the aldehyde dehydrogenase family
GZH82_RS01950	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GZH82_RS01955	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GZH82_RS01965	COG0107	imidazoleglycerol-phosphate synthase activity
GZH82_RS01970	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GZH82_RS01985	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GZH82_RS01990	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GZH82_RS01995	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GZH82_RS02000	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GZH82_RS02025	COG2376	Dihydroxyacetone kinase
GZH82_RS02030	COG1461	Dihydroxyacetone kinase
GZH82_RS02035	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
GZH82_RS02040	COG2824	Alkylphosphonate utilization operon protein PhnA
GZH82_RS02045	COG1012	belongs to the aldehyde dehydrogenase family
GZH82_RS02080	COG1131	(ABC) transporter
GZH82_RS02095	COG1668	transmembrane transport
GZH82_RS02115	COG1484	DNA-dependent DNA replication
GZH82_RS02150	COG0596	Alpha beta hydrolase
GZH82_RS02155	COG0789	Transcriptional regulator
GZH82_RS02160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GZH82_RS02160	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZH82_RS02160	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GZH82_RS02170	COG1705	Flagellar rod assembly protein muramidase FlgJ
GZH82_RS02170	COG3942	CHAP domain
GZH82_RS02185	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GZH82_RS02190	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GZH82_RS02195	COG0747	negative chemotaxis
GZH82_RS02220	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GZH82_RS02220	COG0463	Glycosyl transferase, family 2
GZH82_RS02225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GZH82_RS02230	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GZH82_RS02245	COG3181	Tripartite tricarboxylate transporter family receptor
GZH82_RS02250	COG2207	Transcriptional regulator
GZH82_RS02260	COG2211	Major facilitator Superfamily
GZH82_RS02265	COG0778	Nitroreductase
GZH82_RS02270	COG3001	Fructosamine kinase
GZH82_RS02295	COG1136	(ABC) transporter
GZH82_RS02300	COG0577	efflux transmembrane transporter activity
GZH82_RS02320	COG4413	Urea transporter
GZH82_RS02330	COG0832	Belongs to the urease beta subunit family
GZH82_RS02335	COG0804	urea catabolic process
GZH82_RS02340	COG0717	Belongs to the dCTP deaminase family
GZH82_RS02345	COG0523	cobalamin synthesis protein
GZH82_RS02385	COG0583	DNA-binding transcription factor activity
GZH82_RS02395	COG1346	cytolysis
GZH82_RS02410	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GZH82_RS02430	COG1484	DNA-dependent DNA replication
GZH82_RS02450	COG1846	Transcriptional regulator
GZH82_RS02455	COG0778	Nitroreductase
GZH82_RS02460	COG2357	RelA SpoT domain protein
GZH82_RS02495	COG1028	Short-chain dehydrogenase reductase Sdr
GZH82_RS02510	COG1349	DNA-binding transcription factor activity
GZH82_RS02520	COG1070	Carbohydrate kinase
GZH82_RS02525	COG0235	Class ii aldolase
GZH82_RS02540	COG1012	belongs to the aldehyde dehydrogenase family
GZH82_RS02550	COG3227	Zinc metalloprotease (Elastase)
GZH82_RS02565	COG3835	regulator
GZH82_RS02570	COG2855	membrane
GZH82_RS02575	COG3961	Belongs to the TPP enzyme family
GZH82_RS02580	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GZH82_RS02585	COG0512	Glutamine amidotransferase of anthranilate synthase
GZH82_RS02595	COG0134	indole-3-glycerol-phosphate synthase activity
GZH82_RS02605	COG0133	tryptophan synthase activity
GZH82_RS02610	COG0159	tryptophan synthase activity
GZH82_RS02635	COG0277	FAD linked oxidase domain protein
GZH82_RS02640	COG0247	lactate metabolic process
GZH82_RS02645	COG1132	(ABC) transporter
GZH82_RS02650	COG1132	(ABC) transporter
GZH82_RS02655	COG0346	lactoylglutathione lyase activity
GZH82_RS02675	COG1115	amino acid carrier protein
GZH82_RS02680	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
GZH82_RS02685	COG2814	Major facilitator Superfamily
GZH82_RS02690	COG2271	Major facilitator Superfamily
GZH82_RS02695	COG3764	Sortase (surface protein transpeptidase)
GZH82_RS02700	COG1929	Belongs to the glycerate kinase type-1 family
GZH82_RS02710	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
GZH82_RS02730	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
GZH82_RS02735	COG0702	epimerase
GZH82_RS02740	COG4166	transmembrane transport
GZH82_RS02745	COG0444	Belongs to the ABC transporter superfamily
GZH82_RS02750	COG4608	Belongs to the ABC transporter superfamily
GZH82_RS02755	COG0601	transmembrane transport
GZH82_RS02760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GZH82_RS02765	COG0747	negative chemotaxis
GZH82_RS02770	COG0444	Belongs to the ABC transporter superfamily
GZH82_RS02775	COG4608	Belongs to the ABC transporter superfamily
GZH82_RS02780	COG0601	transmembrane transport
GZH82_RS02785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GZH82_RS02800	COG1760	l-serine dehydratase
GZH82_RS02805	COG1760	l-serine dehydratase
GZH82_RS02840	COG0471	metal ion transport
GZH82_RS02845	COG2116	formate transmembrane transporter activity
GZH82_RS02850	COG0454	-acetyltransferase
GZH82_RS02860	COG1648	precorrin-2 dehydrogenase activity
GZH82_RS02860	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GZH82_RS02865	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GZH82_RS02870	COG2146	nitrite reductase [NAD(P)H] activity
GZH82_RS02875	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GZH82_RS02875	COG1648	precorrin-2 dehydrogenase activity
GZH82_RS02880	COG0737	Belongs to the 5'-nucleotidase family
GZH82_RS02910	COG0018	arginyl-trna synthetase
GZH82_RS02920	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GZH82_RS02925	COG1140	nitrate reductase beta subunit
GZH82_RS02935	COG2181	nitrate reductase activity
GZH82_RS02945	COG4585	Histidine kinase
GZH82_RS02950	COG2197	response regulator
GZH82_RS02960	COG2223	nitrite transmembrane transporter activity
GZH82_RS02965	COG4187	Peptidase family M20/M25/M40
GZH82_RS02975	COG0039	L-malate dehydrogenase activity
GZH82_RS02980	COG1363	Peptidase, m42
GZH82_RS02985	COG0697	spore germination
GZH82_RS02995	COG2807	transmembrane transport
GZH82_RS03020	COG1283	sodium-dependent phosphate transmembrane transporter activity
GZH82_RS03045	COG0492	ferredoxin-NADP+ reductase activity
GZH82_RS03050	COG2814	Major facilitator Superfamily
GZH82_RS03055	COG0604	alcohol dehydrogenase
GZH82_RS03070	COG1620	l-lactate permease
GZH82_RS03075	COG0438	transferase activity, transferring glycosyl groups
GZH82_RS03080	COG0579	oxidoreductase
GZH82_RS03110	COG0577	efflux transmembrane transporter activity
GZH82_RS03145	COG4640	response to antibiotic
GZH82_RS03155	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GZH82_RS03190	COG1304	FMN binding
GZH82_RS03195	COG0523	cobalamin synthesis protein
GZH82_RS03200	COG0786	glutamate:sodium symporter activity
GZH82_RS03205	COG2207	Transcriptional regulator
GZH82_RS03210	COG3250	beta-galactosidase activity
GZH82_RS03230	COG1757	Na H antiporter
GZH82_RS03235	COG2094	Belongs to the DNA glycosylase MPG family
GZH82_RS03240	COG3152	Membrane
GZH82_RS03245	COG4152	abc transporter atp-binding protein
GZH82_RS03250	COG1668	transmembrane transport
GZH82_RS03255	COG1742	UPF0060 membrane protein
GZH82_RS03260	COG2017	converts alpha-aldose to the beta-anomer
GZH82_RS03265	COG2258	MOSC domain
GZH82_RS03270	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GZH82_RS03290	COG1266	CAAX protease self-immunity
GZH82_RS03295	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GZH82_RS03300	COG1074	ATP-dependent DNA helicase activity
GZH82_RS03305	COG0179	Fumarylacetoacetate (FAA) hydrolase
GZH82_RS03315	COG0446	pyridine nucleotide-disulphide oxidoreductase
GZH82_RS03320	COG0561	phosphatase activity
GZH82_RS03335	COG0542	response to heat
GZH82_RS03340	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
GZH82_RS03370	COG0601	transmembrane transport
GZH82_RS03375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GZH82_RS03380	COG0444	Belongs to the ABC transporter superfamily
GZH82_RS03385	COG4608	Belongs to the ABC transporter superfamily
GZH82_RS03390	COG4166	transmembrane transport
GZH82_RS03395	COG0180	Tryptophanyl-tRNA synthetase
GZH82_RS03400	COG1393	Belongs to the ArsC family
GZH82_RS03410	COG3591	Belongs to the peptidase S1B family
GZH82_RS03425	COG1164	Oligoendopeptidase f
GZH82_RS03435	COG2346	COG2346, Truncated hemoglobins
GZH82_RS03450	COG2357	RelA SpoT domain protein
GZH82_RS03460	COG0564	pseudouridine synthase activity
GZH82_RS03465	COG2239	Acts as a magnesium transporter
GZH82_RS03470	COG0569	domain protein
GZH82_RS03470	COG0475	glutathione-regulated potassium exporter activity
GZH82_RS03485	COG0628	permease
GZH82_RS03490	COG1115	amino acid carrier protein
GZH82_RS03495	COG2382	esterase
GZH82_RS03510	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GZH82_RS03530	COG3716	PTS system mannose fructose sorbose family IID component
GZH82_RS03535	COG3715	PTS system
GZH82_RS03560	COG2814	Major facilitator Superfamily
GZH82_RS03565	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GZH82_RS03570	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GZH82_RS03580	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GZH82_RS03585	COG0861	Integral membrane protein TerC family
GZH82_RS03590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GZH82_RS03595	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GZH82_RS03600	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
GZH82_RS03610	COG1696	Membrane protein involved in D-alanine export
GZH82_RS03615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GZH82_RS03625	COG0737	Belongs to the 5'-nucleotidase family
GZH82_RS03665	COG4873	Protein conserved in bacteria
GZH82_RS03685	COG4619	ABC transporter
GZH82_RS03690	COG0390	transport system, permease component
GZH82_RS03695	COG1575	Belongs to the MenA family. Type 1 subfamily
GZH82_RS03700	COG1169	isochorismate synthase
GZH82_RS03705	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GZH82_RS03715	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GZH82_RS03720	COG0436	Aminotransferase
GZH82_RS03725	COG3594	Acyltransferase
GZH82_RS03750	COG1316	TRANSCRIPTIONal
GZH82_RS03755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GZH82_RS03765	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
GZH82_RS03785	COG1682	transport, permease protein
GZH82_RS03795	COG1134	teichoic acid transport
GZH82_RS03805	COG0438	transferase activity, transferring glycosyl groups
GZH82_RS03820	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GZH82_RS03825	COG1845	cytochrome c oxidase, subunit III
GZH82_RS03835	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GZH82_RS03845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GZH82_RS03845	COG1017	nitric oxide dioxygenase activity
GZH82_RS03850	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GZH82_RS03855	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GZH82_RS03860	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GZH82_RS03865	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GZH82_RS03870	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GZH82_RS03875	COG0047	phosphoribosylformylglycinamidine synthase activity
GZH82_RS03885	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GZH82_RS03890	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GZH82_RS03900	COG0138	bifunctional purine biosynthesis protein purh
GZH82_RS03905	COG0151	Belongs to the GarS family
GZH82_RS03915	COG4172	Belongs to the ABC transporter superfamily
GZH82_RS03930	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GZH82_RS03940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZH82_RS03945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GZH82_RS03950	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GZH82_RS03955	COG1271	oxidase subunit
GZH82_RS03960	COG1294	oxidase, subunit
GZH82_RS03965	COG0569	domain protein
GZH82_RS03975	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GZH82_RS04020	COG4476	Belongs to the UPF0223 family
GZH82_RS04030	COG3842	ATPase activity
GZH82_RS04040	COG1177	transmembrane transport
GZH82_RS04045	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GZH82_RS04060	COG4493	Belongs to the UPF0637 family
GZH82_RS04065	COG0483	inositol monophosphate 1-phosphatase activity
GZH82_RS04080	COG1902	pentaerythritol trinitrate reductase activity
GZH82_RS04085	COG4896	Protein conserved in bacteria
GZH82_RS04090	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GZH82_RS04095	COG4838	Belongs to the UPF0358 family
GZH82_RS04100	COG0772	Belongs to the SEDS family
GZH82_RS04115	COG1612	heme a metabolic process
GZH82_RS04120	COG0109	protoheme IX farnesyltransferase activity
GZH82_RS04140	COG3679	Belongs to the UPF0342 family
GZH82_RS04145	COG0584	glycerophosphoryl diester phosphodiesterase
GZH82_RS04150	COG4471	UPF0298 protein
GZH82_RS04160	COG0742	ribosomal rna small subunit methyltransferase
GZH82_RS04180	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GZH82_RS04185	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GZH82_RS04190	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GZH82_RS04205	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GZH82_RS04220	COG1796	DNA polymerase
GZH82_RS04220	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GZH82_RS04225	COG1193	negative regulation of DNA recombination
GZH82_RS04230	COG3118	belongs to the thioredoxin family
GZH82_RS04235	COG0322	excinuclease ABC activity
GZH82_RS04240	COG2009	succinate dehydrogenase
GZH82_RS04245	COG1053	succinate dehydrogenase
GZH82_RS04250	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GZH82_RS04340	COG3728	DNA packaging
GZH82_RS04340	COG5484	DNA packaging
GZH82_RS04395	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GZH82_RS04410	COG1011	Hydrolase
GZH82_RS04415	COG0454	-acetyltransferase
GZH82_RS04420	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
GZH82_RS04425	COG2001	Belongs to the MraZ family
GZH82_RS04430	COG0275	rRNA processing
GZH82_RS04435	COG4839	cell division protein FtsL
GZH82_RS04450	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GZH82_RS04460	COG0849	cell division
GZH82_RS04475	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GZH82_RS04480	COG1799	cell septum assembly
GZH82_RS04485	COG0762	integral membrane protein
GZH82_RS04505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GZH82_RS04510	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GZH82_RS04520	COG4409	exo-alpha-(2->6)-sialidase activity
GZH82_RS04525	COG0673	inositol 2-dehydrogenase activity
GZH82_RS04535	COG3599	regulation of cell shape
GZH82_RS04540	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GZH82_RS04545	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GZH82_RS04550	COG0564	pseudouridine synthase activity
GZH82_RS04555	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GZH82_RS04575	COG0505	Belongs to the CarA family
GZH82_RS04580	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GZH82_RS04590	COG0167	dihydroorotate dehydrogenase activity
GZH82_RS04595	COG0284	orotidine-5'-phosphate decarboxylase activity
GZH82_RS04600	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GZH82_RS04620	COG1758	RNA polymerase activity
GZH82_RS04630	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GZH82_RS04635	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GZH82_RS04640	COG0242	peptide deformylase activity
GZH82_RS04645	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GZH82_RS04650	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GZH82_RS04650	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GZH82_RS04655	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GZH82_RS04670	COG2124	cytochrome p450
GZH82_RS04675	COG1162	GTPase activity
GZH82_RS04680	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GZH82_RS04695	COG1302	Protein conserved in bacteria
GZH82_RS04705	COG1760	l-serine dehydratase
GZH82_RS04710	COG1760	l-serine dehydratase
GZH82_RS04720	COG1349	DNA-binding transcription factor activity
GZH82_RS04725	COG0416	fatty acid biosynthetic process
GZH82_RS04740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GZH82_RS04745	COG0571	ribonuclease III activity
GZH82_RS04750	COG1196	nuclear chromosome segregation
GZH82_RS04755	COG0552	protein localization to endoplasmic reticulum
GZH82_RS04760	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
GZH82_RS04765	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GZH82_RS04780	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GZH82_RS04795	COG1597	lipid kinase activity
GZH82_RS04835	COG0488	(ABC) transporter
GZH82_RS04850	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GZH82_RS04860	COG1528	Iron-storage protein
GZH82_RS04890	COG1028	Short-chain dehydrogenase reductase Sdr
GZH82_RS04905	COG1484	DNA-dependent DNA replication
GZH82_RS04910	COG1917	Cupin 2, conserved barrel domain protein
GZH82_RS04920	COG0151	Belongs to the GarS family
GZH82_RS04925	COG2814	Major facilitator Superfamily
GZH82_RS04935	COG0436	Aminotransferase
GZH82_RS04945	COG4129	membrane
GZH82_RS04950	COG0024	Methionine aminopeptidase
GZH82_RS04975	COG0288	reversible hydration of carbon dioxide
GZH82_RS04980	COG1295	ribonuclease BN
GZH82_RS04995	COG4840	Belongs to the UPF0435 family
GZH82_RS05000	COG2309	aminopeptidase activity
GZH82_RS05005	COG1607	acyl-coa hydrolase
GZH82_RS05010	COG0535	radical SAM domain protein
GZH82_RS05015	COG0693	protein deglycase activity
GZH82_RS05020	COG0028	Belongs to the TPP enzyme family
GZH82_RS05025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GZH82_RS05040	COG1134	teichoic acid transport
GZH82_RS05040	COG1388	LysM domain
GZH82_RS05050	COG1988	membrane-bound metal-dependent
GZH82_RS05055	COG1194	a g-specific adenine glycosylase
GZH82_RS05060	COG3557	Belongs to the UPF0374 family
GZH82_RS05070	COG0069	glutamate synthase activity
GZH82_RS05075	COG4129	membrane
GZH82_RS05080	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GZH82_RS05085	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GZH82_RS05090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GZH82_RS05095	COG0735	belongs to the Fur family
GZH82_RS05245	COG0765	amino acid transport
GZH82_RS05250	COG1126	abc transporter atp-binding protein
GZH82_RS05255	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GZH82_RS05260	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GZH82_RS05265	COG0363	glucosamine-6-phosphate deaminase activity
GZH82_RS05275	COG0114	fumarate hydratase activity
GZH82_RS05285	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GZH82_RS05290	COG0564	pseudouridine synthase activity
GZH82_RS05295	COG4585	Histidine kinase
GZH82_RS05295	COG2203	Gaf domain
GZH82_RS05300	COG2197	response regulator
GZH82_RS05310	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GZH82_RS05320	COG3344	reverse transcriptase
GZH82_RS05325	COG4399	Belongs to the UPF0754 family
GZH82_RS05330	COG3679	Belongs to the UPF0342 family
GZH82_RS05335	COG0420	3'-5' exonuclease activity
GZH82_RS05345	COG3481	metal-dependent phosphohydrolase, HD sub domain
GZH82_RS05350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GZH82_RS05365	COG1846	Transcriptional regulator
GZH82_RS05375	COG0537	adenosine 5'-monophosphoramidase activity
GZH82_RS05380	COG1131	(ABC) transporter
GZH82_RS05385	COG4473	ABC transporter
GZH82_RS05395	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GZH82_RS05410	COG3545	Serine hydrolase
GZH82_RS05415	COG3344	reverse transcriptase
GZH82_RS05465	COG0582	viral genome integration into host DNA
GZH82_RS05475	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GZH82_RS05620	COG4695	Portal protein
GZH82_RS05670	COG0739	heme binding
GZH82_RS05715	COG5632	N-Acetylmuramoyl-L-alanine amidase
GZH82_RS05715	COG1388	LysM domain
GZH82_RS05765	COG3344	reverse transcriptase
GZH82_RS05870	COG4824	toxin secretion phage lysis holin
GZH82_RS05935	COG0488	(ABC) transporter
GZH82_RS05960	COG3037	sugar-specific permease SgaT UlaA
GZH82_RS05980	COG3623	hexulose-6-phosphate isomerase
GZH82_RS05985	COG0235	Class ii aldolase
GZH82_RS06005	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GZH82_RS06010	COG0494	nUDIX hydrolase
GZH82_RS06015	COG1506	peptidase
GZH82_RS06025	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GZH82_RS06030	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GZH82_RS06040	COG0656	L-ascorbic acid biosynthetic process
GZH82_RS06045	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GZH82_RS06050	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GZH82_RS06060	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GZH82_RS06085	COG4193	domain, Protein
GZH82_RS06085	COG3266	domain, Protein
GZH82_RS06085	COG5632	N-Acetylmuramoyl-L-alanine amidase
GZH82_RS06095	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GZH82_RS06095	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GZH82_RS06100	COG0307	riboflavin synthase, alpha
GZH82_RS06105	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GZH82_RS06105	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GZH82_RS06110	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GZH82_RS06125	COG2267	carboxylic ester hydrolase activity
GZH82_RS06130	COG0039	L-malate dehydrogenase activity
GZH82_RS06140	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GZH82_RS06145	COG1242	4 iron, 4 sulfur cluster binding
GZH82_RS06150	COG2814	Major facilitator Superfamily
GZH82_RS06155	COG0495	leucyl-tRNA aminoacylation
GZH82_RS06160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GZH82_RS06165	COG2081	HI0933 family
GZH82_RS06170	COG2244	polysaccharide biosynthetic process
GZH82_RS06175	COG1187	pseudouridine synthase activity
GZH82_RS06185	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GZH82_RS06190	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GZH82_RS06195	COG0510	thiamine kinase activity
GZH82_RS06205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GZH82_RS06215	COG1363	Peptidase, m42
GZH82_RS06220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GZH82_RS06225	COG4848	Belongs to the UPF0354 family
GZH82_RS06230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GZH82_RS06235	COG1674	ftsk spoiiie
GZH82_RS06240	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GZH82_RS06245	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
GZH82_RS06255	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GZH82_RS06255	COG1605	Chorismate mutase
GZH82_RS06260	COG1609	Transcriptional regulator
GZH82_RS06265	COG0123	including yeast histone deacetylase and acetoin utilization protein
GZH82_RS06270	COG0454	-acetyltransferase
GZH82_RS06275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GZH82_RS06280	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GZH82_RS06285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GZH82_RS06295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GZH82_RS06300	COG0204	Acyl-transferase
GZH82_RS06310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GZH82_RS06315	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GZH82_RS06320	COG1764	response to oxidative stress
GZH82_RS06325	COG0584	glycerophosphoryl diester phosphodiesterase
GZH82_RS06345	COG3344	reverse transcriptase
GZH82_RS06360	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GZH82_RS06365	COG1956	GAF domain-containing protein
GZH82_RS06370	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
GZH82_RS06375	COG1104	cysteine desulfurase activity
GZH82_RS06380	COG0301	tRNA thio-modification
GZH82_RS06390	COG0616	signal peptide processing
GZH82_RS06395	COG1714	RDD family
GZH82_RS06400	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GZH82_RS06405	COG0827	DNA restriction-modification system
GZH82_RS06410	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GZH82_RS06415	COG0589	response to stress
GZH82_RS06425	COG3142	Participates in the control of copper homeostasis
GZH82_RS06435	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GZH82_RS06445	COG4109	DRTGG domain
GZH82_RS06450	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GZH82_RS06455	COG0587	DNA-directed DNA polymerase activity
GZH82_RS06460	COG0281	malic enzyme
GZH82_RS06465	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GZH82_RS06470	COG0825	malonyl-CoA metabolic process
GZH82_RS06475	COG0205	6-phosphofructokinase activity
GZH82_RS06480	COG0469	pyruvate kinase activity
GZH82_RS06485	COG0372	Belongs to the citrate synthase family
GZH82_RS06490	COG0538	isocitrate dehydrogenase activity
GZH82_RS06495	COG0745	RESPONSE REGULATOR receiver
GZH82_RS06500	COG5002	protein histidine kinase activity
GZH82_RS06505	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GZH82_RS06505	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GZH82_RS06515	COG0237	dephospho-CoA kinase activity
GZH82_RS06530	COG3611	Membrane attachment protein
GZH82_RS06535	COG1484	DNA-dependent DNA replication
GZH82_RS06540	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GZH82_RS06545	COG0833	amino acid
GZH82_RS06555	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GZH82_RS06560	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GZH82_RS06570	COG4112	unkown
GZH82_RS06580	COG0544	peptidyl-prolyl cis-trans isomerase activity
GZH82_RS06590	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GZH82_RS06595	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GZH82_RS06605	COG0181	hydroxymethylbilane synthase activity
GZH82_RS06620	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GZH82_RS06630	COG2818	Glycosylase
GZH82_RS06635	COG0525	valine-tRNA ligase activity
GZH82_RS06640	COG0285	dihydrofolate synthase activity
GZH82_RS06650	COG2003	Belongs to the UPF0758 family
GZH82_RS06675	COG2868	ribosomal protein
GZH82_RS06685	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GZH82_RS06695	COG0632	four-way junction helicase activity
GZH82_RS06700	COG2255	four-way junction helicase activity
GZH82_RS06715	COG1862	Preprotein translocase
GZH82_RS06720	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GZH82_RS06720	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GZH82_RS06725	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GZH82_RS06725	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GZH82_RS06730	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GZH82_RS06740	COG1490	D-aminoacyl-tRNA deacylase activity
GZH82_RS06745	COG0860	N-Acetylmuramoyl-L-alanine amidase
GZH82_RS06755	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GZH82_RS06765	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GZH82_RS06770	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GZH82_RS06775	COG1959	2 iron, 2 sulfur cluster binding
GZH82_RS06800	COG2815	serine threonine protein kinase
GZH82_RS06800	COG0515	serine threonine protein kinase
GZH82_RS06805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GZH82_RS06825	COG3973	AAA domain
GZH82_RS06830	COG2814	Major facilitator Superfamily
GZH82_RS06835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GZH82_RS06840	COG1104	cysteine desulfurase activity
GZH82_RS06845	COG0482	sulfurtransferase activity
GZH82_RS06855	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GZH82_RS06860	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GZH82_RS06865	COG4472	Bacterial protein of unknown function (DUF965)
GZH82_RS06870	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GZH82_RS06875	COG3906	Belongs to the UPF0473 family
GZH82_RS06880	COG4122	O-methyltransferase activity
GZH82_RS06895	COG0572	uridine kinase
GZH82_RS06905	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GZH82_RS06910	COG1984	allophanate hydrolase subunit 2
GZH82_RS06915	COG0511	ligase activity, forming carbon-carbon bonds
GZH82_RS06920	COG0439	Biotin carboxylase
GZH82_RS06925	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GZH82_RS06930	COG1914	H( )-stimulated, divalent metal cation uptake system
GZH82_RS06935	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GZH82_RS06940	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GZH82_RS06945	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GZH82_RS06950	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GZH82_RS06955	COG1534	Rna-binding protein
GZH82_RS06965	COG1713	HD superfamily hydrolase involved in NAD metabolism
GZH82_RS06970	COG0799	negative regulation of ribosome biogenesis
GZH82_RS06975	COG2226	methyltransferase
GZH82_RS06980	COG1555	photosystem II stabilization
GZH82_RS06980	COG1596	polysaccharide export
GZH82_RS06985	COG2131	deaminase
GZH82_RS06995	COG1466	dna polymerase III delta subunit
GZH82_RS07000	COG0268	Binds directly to 16S ribosomal RNA
GZH82_RS07010	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GZH82_RS07020	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GZH82_RS07030	COG0484	heat shock protein binding
GZH82_RS07035	COG2264	protein methyltransferase activity
GZH82_RS07040	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GZH82_RS07045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GZH82_RS07055	COG1030	water channel activity
GZH82_RS07060	COG4864	UPF0365 protein
GZH82_RS07070	COG1702	phosphate starvation-inducible protein PhoH
GZH82_RS07080	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GZH82_RS07090	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GZH82_RS07095	COG1381	Involved in DNA repair and RecF pathway recombination
GZH82_RS07100	COG0423	glycine-tRNA ligase activity
GZH82_RS07105	COG0517	IMP dehydrogenase activity
GZH82_RS07110	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GZH82_RS07115	COG0358	DNA primase activity
GZH82_RS07120	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GZH82_RS07125	COG2384	SAM-dependent methyltransferase
GZH82_RS07130	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GZH82_RS07135	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GZH82_RS07140	COG0513	Belongs to the DEAD box helicase family
GZH82_RS07145	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GZH82_RS07150	COG1121	(ABC) transporter
GZH82_RS07155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GZH82_RS07160	COG0735	belongs to the Fur family
GZH82_RS07165	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GZH82_RS07180	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GZH82_RS07185	COG0573	inorganic phosphate transmembrane transporter activity
GZH82_RS07190	COG0581	inorganic phosphate transmembrane transporter activity
GZH82_RS07195	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GZH82_RS07200	COG0704	Plays a role in the regulation of phosphate uptake
GZH82_RS07210	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GZH82_RS07215	COG0457	Tetratricopeptide repeat
GZH82_RS07215	COG0705	Rhomboid family
GZH82_RS07220	COG4483	Protein conserved in bacteria
GZH82_RS07225	COG1940	carbohydrate kinase activity
GZH82_RS07230	COG0011	TIGRFAM Protein of
GZH82_RS07235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GZH82_RS07240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GZH82_RS07270	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GZH82_RS07275	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GZH82_RS07285	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GZH82_RS07290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GZH82_RS07295	COG0095	Lipoate-protein ligase
GZH82_RS07310	COG0006	proline dipeptidase activity
GZH82_RS07315	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GZH82_RS07320	COG0511	ligase activity, forming carbon-carbon bonds
GZH82_RS07325	COG0439	Biotin carboxylase
GZH82_RS07330	COG1302	Protein conserved in bacteria
GZH82_RS07340	COG1570	exodeoxyribonuclease VII activity
GZH82_RS07355	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GZH82_RS07360	COG1438	arginine binding
GZH82_RS07365	COG0497	DNA recombination
GZH82_RS07370	COG0280	phosphate acetyltransferase
GZH82_RS07375	COG3426	butyrate kinase activity
GZH82_RS07380	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GZH82_RS07385	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GZH82_RS07390	COG0022	dehydrogenase e1 component
GZH82_RS07395	COG0508	dehydrogenase complex catalyzes the overall conversion of
GZH82_RS07405	COG4129	membrane
GZH82_RS07415	COG2195	Cleaves the N-terminal amino acid of tripeptides
GZH82_RS07435	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GZH82_RS07440	COG1234	tRNA 3'-trailer cleavage
GZH82_RS07445	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GZH82_RS07455	COG0667	Aldo Keto reductase
GZH82_RS07460	COG0494	nUDIX hydrolase
GZH82_RS07465	COG0735	belongs to the Fur family
GZH82_RS07480	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GZH82_RS07485	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GZH82_RS07490	COG1187	pseudouridine synthase activity
GZH82_RS07495	COG0745	RESPONSE REGULATOR receiver
GZH82_RS07510	COG1141	Ferredoxin
GZH82_RS07520	COG0514	ATP-dependent DNA helicase (RecQ)
GZH82_RS07530	COG0492	ferredoxin-NADP+ reductase activity
GZH82_RS07535	COG0252	asparaginase activity
GZH82_RS07545	COG0539	negative regulation of cytoplasmic translation
GZH82_RS07555	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GZH82_RS07575	COG0142	geranyltranstransferase activity
GZH82_RS07580	COG0105	UTP biosynthetic process
GZH82_RS07590	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GZH82_RS07595	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GZH82_RS07600	COG0457	Tetratricopeptide repeat
GZH82_RS07605	COG5582	Belongs to the UPF0302 family
GZH82_RS07610	COG4347	Protein of unknown function (DUF1405)
GZH82_RS07620	COG1694	Mazg nucleotide pyrophosphohydrolase
GZH82_RS07625	COG0438	transferase activity, transferring glycosyl groups
GZH82_RS07630	COG0617	tRNA 3'-terminal CCA addition
GZH82_RS07645	COG0017	Asparaginyl-tRNA synthetase
GZH82_RS07650	COG3935	DnaD domain protein
GZH82_RS07655	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GZH82_RS07665	COG4499	WXG100 protein secretion system (Wss), protein YukC
GZH82_RS07665	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GZH82_RS07680	COG4474	Belongs to the UPF0398 family
GZH82_RS07685	COG3599	regulation of cell shape
GZH82_RS07695	COG0116	Belongs to the methyltransferase superfamily
GZH82_RS07700	COG2962	Rard protein
GZH82_RS07705	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GZH82_RS07710	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GZH82_RS07720	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GZH82_RS07730	COG1413	lyase activity
GZH82_RS07765	COG2190	(PTS) system
GZH82_RS07775	COG0793	Belongs to the peptidase S41A family
GZH82_RS07785	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GZH82_RS07790	COG0671	phosphoesterase, PA-phosphatase related
GZH82_RS07810	COG5002	protein histidine kinase activity
GZH82_RS07815	COG0567	Dehydrogenase, E1 component
GZH82_RS07840	COG0714	Associated with various cellular activities
GZH82_RS07845	COG4548	von Willebrand factor, type A
GZH82_RS07850	COG1114	Component of the transport system for branched-chain amino acids
GZH82_RS07865	COG3853	Toxic anion resistance protein (TelA)
GZH82_RS07885	COG1278	Cold shock
GZH82_RS07900	COG1473	amidohydrolase
GZH82_RS07905	COG2171	N-acyltransferase activity
GZH82_RS07910	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GZH82_RS07915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GZH82_RS07920	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GZH82_RS07930	COG0488	(ABC) transporter
GZH82_RS07935	COG2996	Protein conserved in bacteria
GZH82_RS07970	COG1363	Peptidase, m42
GZH82_RS07975	COG0287	Prephenate dehydrogenase
GZH82_RS07980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GZH82_RS08010	COG0628	permease
GZH82_RS08020	COG3711	transcriptional antiterminator
GZH82_RS08025	COG1115	amino acid carrier protein
GZH82_RS08030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GZH82_RS08040	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GZH82_RS08045	COG4841	protein insertion into membrane
GZH82_RS08050	COG0824	Thioesterase
GZH82_RS08060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GZH82_RS08065	COG1970	mechanosensitive ion channel activity
GZH82_RS08075	COG0420	3'-5' exonuclease activity
GZH82_RS08080	COG4846	Membrane protein involved in cytochrome C biogenesis
GZH82_RS08085	COG3763	UPF0154 protein
GZH82_RS08095	COG4224	UPF0291 protein
GZH82_RS08105	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GZH82_RS08115	COG0516	GMP reductase activity
GZH82_RS08120	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GZH82_RS08130	COG0833	amino acid
GZH82_RS08145	COG0083	homoserine kinase activity
GZH82_RS08150	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GZH82_RS08155	COG0460	homoserine dehydrogenase
GZH82_RS08160	COG0527	aspartate kinase activity
GZH82_RS08180	COG1525	nuclease
GZH82_RS08200	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GZH82_RS08210	COG1525	nuclease
GZH82_RS08220	COG0584	glycerophosphoryl diester phosphodiesterase
GZH82_RS08240	COG0789	Transcriptional regulator
GZH82_RS08245	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
GZH82_RS08250	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GZH82_RS08255	COG0386	Belongs to the glutathione peroxidase family
GZH82_RS08280	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GZH82_RS08285	COG1923	regulation of RNA biosynthetic process
GZH82_RS08290	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GZH82_RS08300	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GZH82_RS08305	COG1619	proteins homologs of microcin C7 resistance protein MccF
GZH82_RS08310	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
GZH82_RS08315	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GZH82_RS08335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GZH82_RS08345	COG1013	pyruvate-flavodoxin oxidoreductase activity
GZH82_RS08350	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
GZH82_RS08350	COG0674	pyruvate-flavodoxin oxidoreductase activity
GZH82_RS08355	COG1692	metallophosphoesterase
GZH82_RS08375	COG1418	mRNA catabolic process
GZH82_RS08380	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GZH82_RS08385	COG1058	Belongs to the CinA family
GZH82_RS08385	COG1546	Belongs to the CinA family
GZH82_RS08405	COG0300	oxidoreductase activity
GZH82_RS08410	COG0612	Peptidase, M16
GZH82_RS08415	COG0612	Peptidase, M16
GZH82_RS08420	COG2188	Transcriptional regulator
GZH82_RS08435	COG1185	polyribonucleotide nucleotidyltransferase activity
GZH82_RS08445	COG0196	riboflavin kinase activity
GZH82_RS08450	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GZH82_RS08455	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GZH82_RS08460	COG1447	Phosphotransferase system cellobiose-specific component IIA
GZH82_RS08465	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GZH82_RS08475	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GZH82_RS08490	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GZH82_RS08495	COG1358	cellular component organization or biogenesis
GZH82_RS08500	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GZH82_RS08505	COG0195	Participates in both transcription termination and antitermination
GZH82_RS08510	COG0779	Required for maturation of 30S ribosomal subunits
GZH82_RS08520	COG0442	prolyl-tRNA aminoacylation
GZH82_RS08530	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GZH82_RS08535	COG4589	Belongs to the CDS family
GZH82_RS08545	COG0233	cytoplasmic translational termination
GZH82_RS08550	COG0528	UMP kinase activity
GZH82_RS08555	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GZH82_RS08560	COG0052	Belongs to the universal ribosomal protein uS2 family
GZH82_RS08565	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GZH82_RS08570	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GZH82_RS08575	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GZH82_RS08580	COG4974	Belongs to the 'phage' integrase family
GZH82_RS08585	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GZH82_RS08590	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GZH82_RS08595	COG0758	DNA mediated transformation
GZH82_RS08605	COG0045	succinate-CoA ligase (ADP-forming) activity
GZH82_RS08615	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GZH82_RS08630	COG4485	Bacterial membrane protein, YfhO
GZH82_RS08655	COG0336	Belongs to the RNA methyltransferase TrmD family
GZH82_RS08660	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GZH82_RS08665	COG0228	four-way junction DNA binding
GZH82_RS08690	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GZH82_RS08695	COG0154	amidase activity
GZH82_RS08700	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GZH82_RS08705	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GZH82_RS08710	COG4851	CamS sex pheromone cAM373 precursor
GZH82_RS08715	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GZH82_RS08725	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
GZH82_RS08730	COG4496	protein, YerC YecD
GZH82_RS08735	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GZH82_RS08745	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
GZH82_RS08755	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GZH82_RS08765	COG0077	Prephenate dehydratase
GZH82_RS08765	COG1605	Chorismate mutase
GZH82_RS08775	COG1335	isochorismatase
GZH82_RS08780	COG1227	inorganic diphosphatase activity
GZH82_RS08790	COG1012	belongs to the aldehyde dehydrogenase family
GZH82_RS08795	COG2706	6-phosphogluconolactonase activity
GZH82_RS08830	COG2610	gluconate transmembrane transporter activity
GZH82_RS08850	COG1131	(ABC) transporter
GZH82_RS08865	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GZH82_RS08870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GZH82_RS08885	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GZH82_RS08910	COG4512	PFAM Accessory gene regulator B
GZH82_RS08935	COG1621	beta-fructofuranosidase activity
GZH82_RS08940	COG1609	Transcriptional regulator
GZH82_RS08945	COG2391	methyltransferase activity
GZH82_RS08950	COG0425	Belongs to the sulfur carrier protein TusA family
GZH82_RS08955	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GZH82_RS08960	COG0488	(ABC) transporter
GZH82_RS08970	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GZH82_RS08975	COG0456	acetyltransferase
GZH82_RS08980	COG1214	PFAM Peptidase M22, glycoprotease
GZH82_RS08985	COG0802	atpase or kinase
GZH82_RS08990	COG0129	dihydroxy-acid dehydratase activity
GZH82_RS08995	COG0028	Belongs to the TPP enzyme family
GZH82_RS09005	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GZH82_RS09010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GZH82_RS09015	COG0473	3-isopropylmalate dehydrogenase activity
GZH82_RS09020	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GZH82_RS09025	COG0066	3-isopropylmalate dehydratase activity
GZH82_RS09070	COG3091	SprT-like family
GZH82_RS09075	COG2183	response to ionizing radiation
GZH82_RS09080	COG1191	sigma factor activity
GZH82_RS09090	COG1366	Belongs to the anti-sigma-factor antagonist family
GZH82_RS09095	COG2208	phosphoserine phosphatase activity
GZH82_RS09100	COG2337	Toxic component of a toxin-antitoxin (TA) module
GZH82_RS09115	COG0736	holo-[acyl-carrier-protein] synthase activity
GZH82_RS09120	COG3402	PFAM membrane-flanked domain
GZH82_RS09135	COG0513	Belongs to the DEAD box helicase family
GZH82_RS09140	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GZH82_RS09145	COG1181	Belongs to the D-alanine--D-alanine ligase family
GZH82_RS09150	COG0772	Belongs to the SEDS family
GZH82_RS09160	COG2217	Heavy metal translocating P-type atpase
GZH82_RS09175	COG1937	Protein conserved in bacteria
GZH82_RS09180	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GZH82_RS09185	COG1418	mRNA catabolic process
GZH82_RS09190	COG0706	membrane insertase activity
GZH82_RS09195	COG0352	thiamine-phosphate diphosphorylase activity
GZH82_RS09200	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GZH82_RS09210	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GZH82_RS09225	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GZH82_RS09255	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GZH82_RS09265	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GZH82_RS09275	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GZH82_RS09280	COG0356	it plays a direct role in the translocation of protons across the membrane
GZH82_RS09290	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GZH82_RS09295	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GZH82_RS09305	COG4475	Protein of unknown function (DUF436)
GZH82_RS09310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GZH82_RS09315	COG0009	L-threonylcarbamoyladenylate synthase
GZH82_RS09320	COG2890	protein-(glutamine-N5) methyltransferase activity
GZH82_RS09325	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GZH82_RS09335	COG0254	rRNA binding
GZH82_RS09340	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GZH82_RS09350	COG1733	regulation of RNA biosynthetic process
GZH82_RS09355	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GZH82_RS09360	COG0191	fructose-bisphosphate aldolase activity
GZH82_RS09365	COG4821	SIS domain
GZH82_RS09370	COG2271	Major facilitator Superfamily
GZH82_RS09375	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GZH82_RS09385	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GZH82_RS09390	COG0504	CTP synthase activity
GZH82_RS09400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GZH82_RS09435	COG5146	pantothenate kinase activity
GZH82_RS09465	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GZH82_RS09470	COG0813	purine-nucleoside phosphorylase activity
GZH82_RS09505	COG1482	cell wall glycoprotein biosynthetic process
GZH82_RS09510	COG2186	Transcriptional regulator
GZH82_RS09520	COG0561	phosphatase activity
GZH82_RS09525	COG1119	ATPase activity
GZH82_RS09545	COG3711	transcriptional antiterminator
GZH82_RS09555	COG0246	Mannitol dehydrogenase
GZH82_RS09560	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GZH82_RS09625	COG0489	protein tyrosine kinase activity
GZH82_RS09630	COG2814	Major facilitator Superfamily
GZH82_RS09650	COG1272	protein, Hemolysin III
GZH82_RS09655	COG4284	Utp--glucose-1-phosphate uridylyltransferase
GZH82_RS09660	COG1988	membrane-bound metal-dependent
GZH82_RS09675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZH82_RS09680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZH82_RS09685	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GZH82_RS09690	COG3457	Alanine racemase
GZH82_RS09695	COG4264	IucA IucC family
GZH82_RS09700	COG2814	Major facilitator Superfamily
GZH82_RS09705	COG4264	IucA IucC family
GZH82_RS09710	COG2814	Major facilitator Superfamily
GZH82_RS09715	COG1302	Protein conserved in bacteria
GZH82_RS09730	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GZH82_RS09750	COG1518	maintenance of DNA repeat elements
GZH82_RS09755	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
GZH82_RS09760	COG2272	Belongs to the type-B carboxylesterase lipase family
GZH82_RS09780	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GZH82_RS09780	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GZH82_RS09790	COG3684	Belongs to the aldolase LacD family
GZH82_RS09805	COG1349	DNA-binding transcription factor activity
GZH82_RS09810	COG1335	isochorismatase
GZH82_RS09825	COG2814	Major facilitator Superfamily
GZH82_RS09835	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GZH82_RS09840	COG0101	tRNA pseudouridine synthase activity
GZH82_RS09850	COG1122	ATPase activity
GZH82_RS09855	COG1122	ATPase activity
GZH82_RS09860	COG0203	ribosomal protein L17
GZH82_RS09865	COG0202	RNA polymerase activity
GZH82_RS09870	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GZH82_RS09880	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GZH82_RS09895	COG0201	protein transport
GZH82_RS09905	COG1841	ribosomal large subunit assembly
GZH82_RS09910	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GZH82_RS09920	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GZH82_RS09925	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GZH82_RS09930	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GZH82_RS09945	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GZH82_RS09955	COG0255	Belongs to the universal ribosomal protein uL29 family
GZH82_RS09960	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GZH82_RS09965	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GZH82_RS09970	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GZH82_RS09975	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GZH82_RS09980	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GZH82_RS09985	COG0089	rRNA binding
GZH82_RS09990	COG0088	Forms part of the polypeptide exit tunnel
GZH82_RS09995	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GZH82_RS10010	COG2252	PERMEase
GZH82_RS10015	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GZH82_RS10015	COG0551	DNA topoisomerase type I activity
GZH82_RS10035	COG0436	Aminotransferase
GZH82_RS10040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GZH82_RS10045	COG2348	transferase activity, transferring amino-acyl groups
GZH82_RS10070	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GZH82_RS10075	COG0746	molybdenum cofactor guanylyltransferase activity
GZH82_RS10085	COG0314	molybdopterin synthase activity
GZH82_RS10095	COG0303	'Molybdopterin
GZH82_RS10105	COG0521	Mo-molybdopterin cofactor biosynthetic process
GZH82_RS10110	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GZH82_RS10115	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GZH82_RS10120	COG4149	molybdate abc transporter
GZH82_RS10125	COG0725	ABC transporter, periplasmic molybdate-binding protein
GZH82_RS10130	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GZH82_RS10135	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GZH82_RS10140	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GZH82_RS10145	COG1609	Transcriptional regulator
GZH82_RS10160	COG1268	BioY protein
GZH82_RS10170	COG2186	Transcriptional regulator
GZH82_RS10180	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GZH82_RS10185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GZH82_RS10190	COG2832	Protein of unknown function (DUF454)
GZH82_RS10195	COG1960	acyl-CoA dehydrogenase activity
GZH82_RS10215	COG3942	CHAP domain
GZH82_RS10225	COG1757	Na H antiporter
GZH82_RS10240	COG3942	CHAP domain
GZH82_RS10245	COG2076	Multidrug Resistance protein
GZH82_RS10250	COG2076	Multidrug Resistance protein
GZH82_RS10255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GZH82_RS10270	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GZH82_RS10275	COG0515	serine threonine protein kinase
GZH82_RS10300	COG4193	domain, Protein
GZH82_RS10320	COG3383	formate dehydrogenase (NAD+) activity
GZH82_RS10325	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GZH82_RS10340	COG1316	TRANSCRIPTIONal
GZH82_RS10365	COG1113	amino acid transport
GZH82_RS10390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GZH82_RS10395	COG0346	lactoylglutathione lyase activity
GZH82_RS10405	COG0385	Bile acid
GZH82_RS10425	COG1473	amidohydrolase
GZH82_RS10430	COG0659	secondary active sulfate transmembrane transporter activity
GZH82_RS10435	COG1228	amidohydrolase
GZH82_RS10440	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GZH82_RS10450	COG0583	DNA-binding transcription factor activity
GZH82_RS10470	COG0166	Belongs to the GPI family
GZH82_RS10475	COG0137	argininosuccinate synthase activity
GZH82_RS10485	COG0584	glycerophosphoryl diester phosphodiesterase
GZH82_RS10500	COG1012	belongs to the aldehyde dehydrogenase family
GZH82_RS10505	COG1098	S1 RNA binding domain
GZH82_RS10515	COG1278	Cold shock
GZH82_RS10535	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GZH82_RS10545	COG2111	Na H antiporter
GZH82_RS10545	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GZH82_RS10550	COG2111	Na H antiporter
GZH82_RS10555	COG1006	Multisubunit Na H antiporter MnhC subunit
GZH82_RS10560	COG0651	ATP synthesis coupled electron transport
GZH82_RS10565	COG1863	multisubunit Na H antiporter MnhE subunit
GZH82_RS10570	COG2212	antiporter activity
GZH82_RS10575	COG1320	monovalent cation:proton antiporter activity
GZH82_RS10585	COG2056	Na+-H+ antiporter family
GZH82_RS10590	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GZH82_RS10595	COG1252	NADH dehydrogenase
GZH82_RS10600	COG0316	Belongs to the HesB IscA family
GZH82_RS10605	COG4844	belongs to the
GZH82_RS10610	COG1252	NADH dehydrogenase
GZH82_RS10615	COG4837	Protein of unknown function (DUF1462)
GZH82_RS10620	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GZH82_RS10625	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GZH82_RS10630	COG0647	UMP catabolic process
GZH82_RS10635	COG2445	Protein of unknown function DUF86
GZH82_RS10645	COG4470	Protein conserved in bacteria
GZH82_RS10650	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GZH82_RS10655	COG0737	Belongs to the 5'-nucleotidase family
GZH82_RS10660	COG0730	response to heat
GZH82_RS10665	COG1801	Protein of unknown function DUF72
GZH82_RS10680	COG4536	flavin adenine dinucleotide binding
GZH82_RS10710	COG0719	Fe-S assembly protein
GZH82_RS10715	COG0822	iron-sulfur transferase activity
GZH82_RS10725	COG0719	Fe-S assembly protein
GZH82_RS10730	COG0396	ATPase activity
GZH82_RS10745	COG1464	Belongs to the NlpA lipoprotein family
GZH82_RS10750	COG1464	Belongs to the NlpA lipoprotein family
GZH82_RS10755	COG2011	ABC-type metal ion transport system permease component
GZH82_RS10760	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GZH82_RS10770	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GZH82_RS10780	COG1393	Belongs to the ArsC family
GZH82_RS10785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GZH82_RS10795	COG0710	3-dehydroquinate dehydratase activity
GZH82_RS10805	COG1764	response to oxidative stress
GZH82_RS10820	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GZH82_RS10850	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GZH82_RS10855	COG0557	exoribonuclease II activity
GZH82_RS10860	COG1647	Serine aminopeptidase, S33
GZH82_RS10865	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GZH82_RS10880	COG0148	phosphopyruvate hydratase activity
GZH82_RS10885	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GZH82_RS10890	COG0149	triose-phosphate isomerase activity
GZH82_RS10895	COG0126	phosphoglycerate kinase activity
GZH82_RS10920	COG1090	epimerase
GZH82_RS10930	COG0740	serine-type endopeptidase activity
GZH82_RS10940	COG1481	regulation of sporulation
GZH82_RS10945	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GZH82_RS10950	COG1660	Displays ATPase and GTPase activities
GZH82_RS10965	COG0110	maltose O-acetyltransferase activity
GZH82_RS10970	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GZH82_RS10975	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GZH82_RS11010	COG0653	protein targeting
GZH82_RS11015	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GZH82_RS11025	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GZH82_RS11035	COG1739	Uncharacterized protein family UPF0029
GZH82_RS11040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GZH82_RS11045	COG2199	diguanylate cyclase activity
GZH82_RS11060	COG2195	Cleaves the N-terminal amino acid of tripeptides
GZH82_RS11065	COG1929	Belongs to the glycerate kinase type-1 family
GZH82_RS11070	COG3118	belongs to the thioredoxin family
GZH82_RS11085	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GZH82_RS11100	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GZH82_RS11105	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GZH82_RS11130	COG3104	oligopeptide transport
GZH82_RS11135	COG3104	oligopeptide transport
GZH82_RS11150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GZH82_RS11155	COG1174	glycine betaine transport
GZH82_RS11160	COG0517	IMP dehydrogenase activity
GZH82_RS11160	COG1125	glycine betaine transport
GZH82_RS11165	COG0514	ATP-dependent DNA helicase (RecQ)
GZH82_RS11170	COG0488	(ABC) transporter
GZH82_RS11180	COG1368	sulfuric ester hydrolase activity
GZH82_RS11190	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GZH82_RS11210	COG0512	Glutamine amidotransferase of anthranilate synthase
GZH82_RS11220	COG0720	synthase
GZH82_RS11225	COG0602	queuosine metabolic process
GZH82_RS11240	COG0463	Glycosyl transferase, family 2
GZH82_RS11245	COG1253	flavin adenine dinucleotide binding
GZH82_RS11250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GZH82_RS11250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GZH82_RS11250	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GZH82_RS11255	COG1105	Belongs to the carbohydrate kinase PfkB family
GZH82_RS11260	COG1349	DNA-binding transcription factor activity
GZH82_RS11275	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GZH82_RS11280	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GZH82_RS11300	COG0039	L-malate dehydrogenase activity
GZH82_RS11320	COG4989	oxidoreductase activity
GZH82_RS11325	COG0523	cobalamin synthesis protein
GZH82_RS11335	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GZH82_RS11340	COG4988	ABC transporter
GZH82_RS11345	COG1968	undecaprenyl-diphosphatase activity
GZH82_RS11355	COG1671	Belongs to the UPF0178 family
GZH82_RS11360	COG1611	Belongs to the LOG family
GZH82_RS11390	COG2839	Protein conserved in bacteria
GZH82_RS11395	COG2814	Major facilitator Superfamily
GZH82_RS11400	COG0583	DNA-binding transcription factor activity
GZH82_RS11415	COG0217	transcriptional regulatory protein
GZH82_RS11420	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GZH82_RS11425	COG2022	thiamine diphosphate biosynthetic process
GZH82_RS11435	COG0352	thiamine-phosphate diphosphorylase activity
GZH82_RS11445	COG1388	LysM domain
GZH82_RS11445	COG3942	CHAP domain
GZH82_RS11450	COG0306	phosphate transporter
GZH82_RS11455	COG1392	Phosphate transport regulator
GZH82_RS11460	COG0577	efflux transmembrane transporter activity
GZH82_RS11465	COG1136	(ABC) transporter
GZH82_RS11475	COG0745	RESPONSE REGULATOR receiver
GZH82_RS11480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GZH82_RS11495	COG3949	Membrane
GZH82_RS11500	COG0477	Major facilitator Superfamily
GZH82_RS11510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZH82_RS11515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZH82_RS11520	COG1120	ATPase activity
GZH82_RS11525	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GZH82_RS11530	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GZH82_RS11550	COG1132	(ABC) transporter
GZH82_RS11555	COG1686	Belongs to the peptidase S11 family
GZH82_RS11575	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GZH82_RS11580	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GZH82_RS11585	COG1682	transport, permease protein
GZH82_RS11595	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GZH82_RS11600	COG0110	maltose O-acetyltransferase activity
GZH82_RS11610	COG1475	DNA binding
GZH82_RS11615	COG0019	diaminopimelate decarboxylase activity
GZH82_RS11625	COG4264	IucA IucC family
GZH82_RS11630	COG4264	IucA IucC family
GZH82_RS11635	COG2814	Major facilitator Superfamily
GZH82_RS11640	COG4264	IucA IucC family
GZH82_RS11645	COG2423	ornithine cyclodeaminase activity
GZH82_RS11655	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GZH82_RS11660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZH82_RS11665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZH82_RS11680	COG1121	(ABC) transporter
GZH82_RS11685	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GZH82_RS11690	COG0803	Belongs to the bacterial solute-binding protein 9 family
GZH82_RS11695	COG1320	monovalent cation:proton antiporter activity
GZH82_RS11700	COG2212	antiporter activity
GZH82_RS11705	COG1863	multisubunit Na H antiporter MnhE subunit
GZH82_RS11715	COG1006	Multisubunit Na H antiporter MnhC subunit
GZH82_RS11720	COG2111	Na H antiporter
GZH82_RS11725	COG2111	Na H antiporter
GZH82_RS11725	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GZH82_RS11770	COG0596	Alpha beta hydrolase
GZH82_RS11775	COG0546	phosphoglycolate phosphatase activity
GZH82_RS11780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GZH82_RS11785	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GZH82_RS11790	COG2822	iron ion transport
GZH82_RS11795	COG2837	iron assimilation
GZH82_RS11800	COG0672	)-iron permease
GZH82_RS11805	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GZH82_RS11810	COG0805	protein transport
GZH82_RS11815	COG0018	arginyl-trna synthetase
GZH82_RS11830	COG1078	dGTPase activity
GZH82_RS11840	COG4844	belongs to the
GZH82_RS11900	COG0471	metal ion transport
GZH82_RS11925	COG0280	phosphate acetyltransferase
GZH82_RS11930	COG0095	Lipoate-protein ligase
GZH82_RS11935	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GZH82_RS11950	COG2814	Major facilitator Superfamily
GZH82_RS11955	COG1566	PFAM secretion protein HlyD family protein
GZH82_RS11965	COG2311	Membrane
GZH82_RS11980	COG2363	Small membrane protein
GZH82_RS11990	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GZH82_RS12000	COG0515	serine threonine protein kinase
GZH82_RS12000	COG2815	serine threonine protein kinase
GZH82_RS12005	COG1132	(ABC) transporter
GZH82_RS12020	COG0183	Belongs to the thiolase family
GZH82_RS12025	COG0318	PFAM AMP-dependent synthetase and ligase
GZH82_RS12030	COG0588	phosphoglycerate mutase activity
GZH82_RS12035	COG0488	(ABC) transporter
GZH82_RS12080	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GZH82_RS12095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZH82_RS12095	COG1263	PTS System
GZH82_RS12095	COG2190	(PTS) system
GZH82_RS12110	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GZH82_RS12115	COG1469	GTP cyclohydrolase I activity
GZH82_RS12140	COG0602	queuosine metabolic process
GZH82_RS12185	COG0561	phosphatase activity
GZH82_RS12195	COG1428	Deoxynucleoside kinase
GZH82_RS12200	COG1428	Deoxynucleoside kinase
GZH82_RS12205	COG0546	phosphoglycolate phosphatase activity
GZH82_RS12235	COG4824	toxin secretion phage lysis holin
GZH82_RS12475	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GZH82_RS12480	COG0488	(ABC) transporter
GZH82_RS12505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GZH82_RS12510	COG0488	(ABC) transporter
GZH82_RS12520	COG1473	amidohydrolase
GZH82_RS12525	COG3527	Alpha-acetolactate decarboxylase
GZH82_RS12535	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GZH82_RS12540	COG0049	tRNA binding
GZH82_RS12545	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GZH82_RS12555	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GZH82_RS12560	COG0085	RNA polymerase activity
GZH82_RS12565	COG2813	Specifically methylates the guanine in position
GZH82_RS12575	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GZH82_RS12580	COG0081	regulation of translation
GZH82_RS12585	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GZH82_RS12590	COG0250	Participates in transcription elongation, termination and antitermination
GZH82_RS12595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GZH82_RS12600	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GZH82_RS12620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
GZH82_RS12625	COG0215	cysteine-tRNA ligase activity
GZH82_RS12635	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GZH82_RS12645	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GZH82_RS12650	COG4956	integral membrane protein (PIN domain superfamily)
GZH82_RS12655	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GZH82_RS12660	COG0542	response to heat
GZH82_RS12665	COG3869	Catalyzes the specific phosphorylation of arginine residues in
GZH82_RS12670	COG3880	PFAM UvrB UvrC protein
GZH82_RS12680	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GZH82_RS12690	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GZH82_RS12695	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GZH82_RS12700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GZH82_RS12705	COG1289	transmembrane transporter activity
GZH82_RS12795	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GZH82_RS12800	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GZH82_RS12820	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GZH82_RS12825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GZH82_RS12840	COG1098	S1 RNA binding domain
GZH82_RS12850	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GZH82_RS12855	COG3956	TIGRFAM MazG family protein
GZH82_RS12860	COG2244	polysaccharide biosynthetic process
GZH82_RS12865	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GZH82_RS12870	COG0193	aminoacyl-tRNA hydrolase activity
GZH82_RS12880	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GZH82_RS12885	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GZH82_RS12895	COG0251	oxidation-reduction process
GZH82_RS12900	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GZH82_RS12905	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GZH82_RS12910	COG4466	Protein conserved in bacteria
GZH82_RS12920	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GZH82_RS12925	COG0084	hydrolase, TatD family'
GZH82_RS12935	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GZH82_RS12940	COG2827	Endonuclease containing a URI domain
GZH82_RS12945	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GZH82_RS12955	COG1774	PSP1 C-terminal conserved region
GZH82_RS12960	COG0470	DNA polymerase III
GZH82_RS12965	COG3870	Protein conserved in bacteria
GZH82_RS12970	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GZH82_RS12975	COG1982	Orn Lys Arg decarboxylase major
GZH82_RS12995	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GZH82_RS13000	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GZH82_RS13005	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GZH82_RS13020	COG2188	Transcriptional regulator
GZH82_RS13025	COG0366	Alpha amylase catalytic
GZH82_RS13030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GZH82_RS13030	COG1263	PTS System
GZH82_RS13050	COG0493	'glutamate synthase
GZH82_RS13055	COG0070	glutamate synthase
GZH82_RS13055	COG0069	glutamate synthase activity
GZH82_RS13055	COG0067	glutamate synthase
GZH82_RS13060	COG0583	DNA-binding transcription factor activity
GZH82_RS13075	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GZH82_RS13115	COG0626	cystathionine gamma-synthase activity
GZH82_RS13120	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GZH82_RS13125	COG2272	Belongs to the type-B carboxylesterase lipase family
GZH82_RS13130	COG0733	neurotransmitter:sodium symporter activity
GZH82_RS13140	COG0745	RESPONSE REGULATOR receiver
GZH82_RS13145	COG2205	protein histidine kinase activity
GZH82_RS13155	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GZH82_RS13160	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GZH82_RS13170	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GZH82_RS13175	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GZH82_RS13175	COG0574	Belongs to the PEP-utilizing enzyme family
GZH82_RS13200	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GZH82_RS13220	COG2814	Major facilitator Superfamily
GZH82_RS13235	COG1124	(ABC) transporter
GZH82_RS13240	COG0444	Belongs to the ABC transporter superfamily
GZH82_RS13245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GZH82_RS13250	COG0601	transmembrane transport
GZH82_RS13255	COG0747	negative chemotaxis
GZH82_RS13275	COG0346	lactoylglutathione lyase activity
GZH82_RS13325	COG1525	nuclease
GZH82_RS13410	COG0582	viral genome integration into host DNA
GZH82_RS13415	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GZH82_RS13415	COG0519	Catalyzes the synthesis of GMP from XMP
GZH82_RS13420	COG0516	GMP reductase activity
GZH82_RS13420	COG0517	IMP dehydrogenase activity
GZH82_RS13425	COG2233	PERMEase
GZH82_RS13430	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GZH82_RS13445	COG5183	chlorophyll binding
GZH82_RS13450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GZH82_RS13455	COG1823	symporter activity
GZH82_RS13480	COG0778	Nitroreductase
GZH82_RS13485	COG0450	alkyl hydroperoxide reductase
GZH82_RS13490	COG3634	alkyl hydroperoxide reductase activity
GZH82_RS13500	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GZH82_RS13510	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GZH82_RS13515	COG2011	ABC-type metal ion transport system permease component
GZH82_RS13520	COG1464	Belongs to the NlpA lipoprotein family
GZH82_RS13525	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GZH82_RS13535	COG3842	ATPase activity
GZH82_RS13540	COG0673	inositol 2-dehydrogenase activity
GZH82_RS13545	COG0395	ABC-type sugar transport system, permease component
GZH82_RS13550	COG1175	transmembrane transport
GZH82_RS13590	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GZH82_RS13600	COG0360	Binds together with S18 to 16S ribosomal RNA
GZH82_RS13605	COG1668	transmembrane transport
GZH82_RS13615	COG0012	GTP binding
GZH82_RS13620	COG4481	Protein conserved in bacteria
GZH82_RS13625	COG0668	transmembrane transport
GZH82_RS13630	COG1475	DNA binding
GZH82_RS13635	COG0626	cystathionine gamma-synthase activity
GZH82_RS13640	COG0626	cystathionine gamma-synthase activity
GZH82_RS13645	COG0646	methionine synthase
GZH82_RS13645	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GZH82_RS13650	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GZH82_RS13700	COG0829	nickel cation binding
GZH82_RS13710	COG0830	nickel cation binding
GZH82_RS13715	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
GZH82_RS13725	COG1966	Carbon starvation protein
GZH82_RS13740	COG1846	Transcriptional regulator
GZH82_RS13745	COG0346	lactoylglutathione lyase activity
GZH82_RS13750	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GZH82_RS13755	COG0400	carboxylic ester hydrolase activity
GZH82_RS13780	COG0357	Ribosomal RNA small subunit methyltransferase G
GZH82_RS13785	COG0445	tRNA wobble uridine modification
GZH82_RS13790	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GZH82_RS13795	COG0594	ribonuclease P activity