locus-tag	class	description
BK815_RS00015	COG3711	transcriptional antiterminator
BK815_RS00020	COG2213	PTS system mannitol-specific
BK815_RS00035	COG1119	ATPase activity
BK815_RS00060	COG0640	Transcriptional regulator
BK815_RS00065	COG0702	epimerase
BK815_RS00070	COG2186	Transcriptional regulator
BK815_RS00075	COG1482	cell wall glycoprotein biosynthetic process
BK815_RS00085	COG2855	membrane
BK815_RS00100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BK815_RS00105	COG0783	Belongs to the Dps family
BK815_RS00110	COG0813	purine-nucleoside phosphorylase activity
BK815_RS00115	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BK815_RS00120	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
BK815_RS00125	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BK815_RS00135	COG1854	S-ribosylhomocysteine lyase activity
BK815_RS00155	COG5146	pantothenate kinase activity
BK815_RS00160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BK815_RS00170	COG0504	CTP synthase activity
BK815_RS00175	COG0191	fructose-bisphosphate aldolase activity
BK815_RS00180	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BK815_RS00190	COG1012	belongs to the aldehyde dehydrogenase family
BK815_RS00195	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BK815_RS00200	COG0254	rRNA binding
BK815_RS00205	COG1435	thymidine kinase activity
BK815_RS00210	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BK815_RS00215	COG2890	protein-(glutamine-N5) methyltransferase activity
BK815_RS00220	COG0009	L-threonylcarbamoyladenylate synthase
BK815_RS00225	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BK815_RS00230	COG4475	Protein of unknown function (DUF436)
BK815_RS00235	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BK815_RS00240	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BK815_RS00245	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BK815_RS00255	COG0356	it plays a direct role in the translocation of protons across the membrane
BK815_RS00260	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BK815_RS00265	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BK815_RS00270	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BK815_RS00275	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BK815_RS00280	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BK815_RS00285	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BK815_RS00290	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BK815_RS00300	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BK815_RS00305	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BK815_RS00315	COG0629	single-stranded DNA binding
BK815_RS00320	COG1388	LysM domain
BK815_RS00325	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BK815_RS00335	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BK815_RS00340	COG0352	thiamine-phosphate diphosphorylase activity
BK815_RS00345	COG0706	membrane insertase activity
BK815_RS00350	COG1418	mRNA catabolic process
BK815_RS00355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BK815_RS00360	COG1937	Protein conserved in bacteria
BK815_RS00370	COG0772	Belongs to the SEDS family
BK815_RS00375	COG1181	Belongs to the D-alanine--D-alanine ligase family
BK815_RS00380	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BK815_RS00385	COG0513	Belongs to the DEAD box helicase family
BK815_RS00395	COG3428	Bacterial PH domain
BK815_RS00410	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BK815_RS00420	COG2337	Toxic component of a toxin-antitoxin (TA) module
BK815_RS00425	COG2208	phosphoserine phosphatase activity
BK815_RS00440	COG1191	sigma factor activity
BK815_RS00450	COG3091	SprT-like family
BK815_RS00480	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BK815_RS00485	COG0066	3-isopropylmalate dehydratase activity
BK815_RS00490	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BK815_RS00495	COG0473	3-isopropylmalate dehydrogenase activity
BK815_RS00500	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BK815_RS00505	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BK815_RS00510	COG0440	acetolactate synthase activity
BK815_RS00515	COG0028	Belongs to the TPP enzyme family
BK815_RS00520	COG0129	dihydroxy-acid dehydratase activity
BK815_RS00525	COG0802	atpase or kinase
BK815_RS00530	COG1214	PFAM Peptidase M22, glycoprotease
BK815_RS00535	COG0456	acetyltransferase
BK815_RS00540	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BK815_RS00550	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BK815_RS00555	COG0488	(ABC) transporter
BK815_RS00560	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BK815_RS00565	COG2391	methyltransferase activity
BK815_RS00570	COG0425	Belongs to the sulfur carrier protein TusA family
BK815_RS00575	COG1609	Transcriptional regulator
BK815_RS00580	COG1621	beta-fructofuranosidase activity
BK815_RS00595	COG3290	protein histidine kinase activity
BK815_RS00605	COG4512	PFAM Accessory gene regulator B
BK815_RS00610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BK815_RS00630	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BK815_RS00635	COG0459	protein refolding
BK815_RS00655	COG1725	Transcriptional regulator
BK815_RS00670	COG1131	(ABC) transporter
BK815_RS00715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BK815_RS00730	COG2706	6-phosphogluconolactonase activity
BK815_RS00735	COG1012	belongs to the aldehyde dehydrogenase family
BK815_RS00740	COG1227	inorganic diphosphatase activity
BK815_RS00745	COG1335	isochorismatase
BK815_RS00755	COG0471	metal ion transport
BK815_RS00760	COG0077	Prephenate dehydratase
BK815_RS00770	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BK815_RS00775	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BK815_RS00780	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BK815_RS00790	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BK815_RS00795	COG4496	protein, YerC YecD
BK815_RS00805	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
BK815_RS00810	COG0210	DNA helicase
BK815_RS00815	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BK815_RS00820	COG4851	CamS sex pheromone cAM373 precursor
BK815_RS00825	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BK815_RS00830	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BK815_RS00835	COG0154	amidase activity
BK815_RS00840	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BK815_RS00845	COG1597	lipid kinase activity
BK815_RS00850	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BK815_RS00860	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BK815_RS00870	COG1528	Iron-storage protein
BK815_RS00885	COG4129	membrane
BK815_RS00890	COG0024	Methionine aminopeptidase
BK815_RS00905	COG4585	Histidine kinase
BK815_RS00910	COG2197	response regulator
BK815_RS00915	COG1295	ribonuclease BN
BK815_RS00925	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BK815_RS00930	COG4840	Belongs to the UPF0435 family
BK815_RS00935	COG2309	aminopeptidase activity
BK815_RS00940	COG1607	acyl-coa hydrolase
BK815_RS00945	COG0535	radical SAM domain protein
BK815_RS00950	COG0693	protein deglycase activity
BK815_RS00955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BK815_RS00960	COG2137	regulation of response to DNA damage stimulus
BK815_RS00970	COG1134	teichoic acid transport
BK815_RS00980	COG1988	membrane-bound metal-dependent
BK815_RS00985	COG1194	a g-specific adenine glycosylase
BK815_RS00990	COG3557	Belongs to the UPF0374 family
BK815_RS01000	COG4129	membrane
BK815_RS01005	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BK815_RS01010	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BK815_RS01015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BK815_RS01020	COG0735	belongs to the Fur family
BK815_RS01160	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BK815_RS01175	COG0765	amino acid transport
BK815_RS01180	COG1126	abc transporter atp-binding protein
BK815_RS01185	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BK815_RS01195	COG0363	glucosamine-6-phosphate deaminase activity
BK815_RS01210	COG0114	fumarate hydratase activity
BK815_RS01215	COG0564	pseudouridine synthase activity
BK815_RS01220	COG4585	Histidine kinase
BK815_RS01220	COG2203	Gaf domain
BK815_RS01225	COG2197	response regulator
BK815_RS01230	COG1301	dicarboxylic acid transport
BK815_RS01235	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BK815_RS01235	COG0463	Glycosyl transferase, family 2
BK815_RS01240	COG1682	transport, permease protein
BK815_RS01245	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BK815_RS01255	COG0506	proline dehydrogenase activity
BK815_RS01265	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BK815_RS01270	COG0384	phenazine biosynthesis protein PhzF
BK815_RS01275	COG0788	formyltetrahydrofolate deformylase activity
BK815_RS01285	COG4399	Belongs to the UPF0754 family
BK815_RS01290	COG3679	Belongs to the UPF0342 family
BK815_RS01295	COG0420	3'-5' exonuclease activity
BK815_RS01300	COG4717	serine-type aminopeptidase activity
BK815_RS01305	COG3481	metal-dependent phosphohydrolase, HD sub domain
BK815_RS01310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BK815_RS01325	COG0537	adenosine 5'-monophosphoramidase activity
BK815_RS01330	COG1131	(ABC) transporter
BK815_RS01335	COG4473	ABC transporter
BK815_RS01345	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BK815_RS01350	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BK815_RS01355	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
BK815_RS01405	COG5294	Protein conserved in bacteria
BK815_RS01420	COG0318	PFAM AMP-dependent synthetase and ligase
BK815_RS01430	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BK815_RS01435	COG0494	nUDIX hydrolase
BK815_RS01440	COG1506	peptidase
BK815_RS01445	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BK815_RS01450	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BK815_RS01460	COG0656	L-ascorbic acid biosynthetic process
BK815_RS01465	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BK815_RS01470	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BK815_RS01480	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BK815_RS01500	COG1595	DNA-templated transcription, initiation
BK815_RS01510	COG5632	N-Acetylmuramoyl-L-alanine amidase
BK815_RS01510	COG4193	domain, Protein
BK815_RS01510	COG3266	domain, Protein
BK815_RS01525	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BK815_RS01525	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BK815_RS01530	COG0307	riboflavin synthase, alpha
BK815_RS01535	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BK815_RS01535	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BK815_RS01540	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BK815_RS01545	COG0506	proline dehydrogenase activity
BK815_RS01550	COG2267	carboxylic ester hydrolase activity
BK815_RS01555	COG0039	L-malate dehydrogenase activity
BK815_RS01565	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BK815_RS01570	COG1242	4 iron, 4 sulfur cluster binding
BK815_RS01575	COG2814	Major facilitator Superfamily
BK815_RS01580	COG0495	leucyl-tRNA aminoacylation
BK815_RS01585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BK815_RS01590	COG2081	HI0933 family
BK815_RS01595	COG2244	polysaccharide biosynthetic process
BK815_RS01600	COG1187	pseudouridine synthase activity
BK815_RS01610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BK815_RS01615	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BK815_RS01620	COG0510	thiamine kinase activity
BK815_RS01625	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BK815_RS01630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BK815_RS01635	COG5584	Small secreted protein
BK815_RS01640	COG1363	Peptidase, m42
BK815_RS01645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BK815_RS01650	COG4848	Belongs to the UPF0354 family
BK815_RS01655	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BK815_RS01660	COG1674	ftsk spoiiie
BK815_RS01665	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BK815_RS01670	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
BK815_RS01680	COG1605	Chorismate mutase
BK815_RS01680	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BK815_RS01685	COG1609	Transcriptional regulator
BK815_RS01690	COG0123	including yeast histone deacetylase and acetoin utilization protein
BK815_RS01695	COG0454	-acetyltransferase
BK815_RS01700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BK815_RS01715	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BK815_RS01720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BK815_RS01725	COG0204	Acyl-transferase
BK815_RS01730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BK815_RS01730	COG1263	PTS System
BK815_RS01740	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BK815_RS01750	COG1764	response to oxidative stress
BK815_RS01755	COG0584	glycerophosphoryl diester phosphodiesterase
BK815_RS01765	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BK815_RS01770	COG1956	GAF domain-containing protein
BK815_RS01775	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BK815_RS01780	COG1104	cysteine desulfurase activity
BK815_RS01785	COG0301	tRNA thio-modification
BK815_RS01795	COG0616	signal peptide processing
BK815_RS01800	COG1714	RDD family
BK815_RS01805	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BK815_RS01810	COG0827	DNA restriction-modification system
BK815_RS01815	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BK815_RS01825	COG0589	response to stress
BK815_RS01830	COG0686	Belongs to the AlaDH PNT family
BK815_RS01835	COG3142	Participates in the control of copper homeostasis
BK815_RS01840	COG0006	proline dipeptidase activity
BK815_RS01845	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BK815_RS01855	COG4109	DRTGG domain
BK815_RS01860	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BK815_RS01865	COG0587	DNA-directed DNA polymerase activity
BK815_RS01870	COG0281	malic enzyme
BK815_RS01875	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BK815_RS01880	COG0825	malonyl-CoA metabolic process
BK815_RS01885	COG0205	6-phosphofructokinase activity
BK815_RS01890	COG0469	pyruvate kinase activity
BK815_RS01895	COG1113	amino acid transport
BK815_RS01900	COG0372	Belongs to the citrate synthase family
BK815_RS01905	COG0538	isocitrate dehydrogenase activity
BK815_RS01910	COG0745	RESPONSE REGULATOR receiver
BK815_RS01915	COG5002	protein histidine kinase activity
BK815_RS01920	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BK815_RS01920	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BK815_RS01930	COG0237	dephospho-CoA kinase activity
BK815_RS01935	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BK815_RS01940	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BK815_RS01945	COG3611	Membrane attachment protein
BK815_RS01950	COG1484	DNA-dependent DNA replication
BK815_RS01955	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BK815_RS01960	COG0833	amino acid
BK815_RS01965	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BK815_RS01970	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BK815_RS01975	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BK815_RS01980	COG4112	unkown
BK815_RS01990	COG0544	peptidyl-prolyl cis-trans isomerase activity
BK815_RS01995	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BK815_RS02000	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BK815_RS02005	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BK815_RS02010	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BK815_RS02015	COG0181	hydroxymethylbilane synthase activity
BK815_RS02025	COG0113	porphobilinogen synthase activity
BK815_RS02030	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BK815_RS02035	COG3180	Ammonia monooxygenase
BK815_RS02040	COG0477	Major facilitator Superfamily
BK815_RS02045	COG2818	Glycosylase
BK815_RS02050	COG0525	valine-tRNA ligase activity
BK815_RS02055	COG0285	dihydrofolate synthase activity
BK815_RS02060	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BK815_RS02065	COG2003	Belongs to the UPF0758 family
BK815_RS02075	COG1522	sequence-specific DNA binding
BK815_RS02080	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BK815_RS02085	COG2814	Major facilitator Superfamily
BK815_RS02145	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BK815_RS02150	COG2868	ribosomal protein
BK815_RS02155	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BK815_RS02160	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BK815_RS02165	COG4492	Belongs to the UPF0735 family
BK815_RS02170	COG0632	four-way junction helicase activity
BK815_RS02175	COG2255	four-way junction helicase activity
BK815_RS02180	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BK815_RS02190	COG1862	Preprotein translocase
BK815_RS02195	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BK815_RS02195	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BK815_RS02200	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BK815_RS02200	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BK815_RS02205	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BK815_RS02215	COG1490	D-aminoacyl-tRNA deacylase activity
BK815_RS02220	COG0860	N-Acetylmuramoyl-L-alanine amidase
BK815_RS02225	COG0124	histidyl-tRNA synthetase
BK815_RS02230	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BK815_RS02240	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BK815_RS02245	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BK815_RS02250	COG1959	2 iron, 2 sulfur cluster binding
BK815_RS02260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BK815_RS02265	COG0488	(ABC) transporter
BK815_RS02270	COG1104	cysteine desulfurase activity
BK815_RS02275	COG0482	sulfurtransferase activity
BK815_RS02285	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BK815_RS02290	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BK815_RS02295	COG4472	Bacterial protein of unknown function (DUF965)
BK815_RS02300	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BK815_RS02305	COG3906	Belongs to the UPF0473 family
BK815_RS02310	COG4122	O-methyltransferase activity
BK815_RS02315	COG0826	peptidase U32
BK815_RS02320	COG0826	peptidase U32
BK815_RS02325	COG0572	uridine kinase
BK815_RS02330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BK815_RS02335	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BK815_RS02340	COG1984	allophanate hydrolase subunit 2
BK815_RS02350	COG0439	Biotin carboxylase
BK815_RS02355	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BK815_RS02360	COG1914	H( )-stimulated, divalent metal cation uptake system
BK815_RS02365	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BK815_RS02370	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BK815_RS02375	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BK815_RS02380	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BK815_RS02385	COG1534	Rna-binding protein
BK815_RS02390	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BK815_RS02395	COG1713	HD superfamily hydrolase involved in NAD metabolism
BK815_RS02400	COG0799	negative regulation of ribosome biogenesis
BK815_RS02405	COG2226	methyltransferase
BK815_RS02410	COG1596	polysaccharide export
BK815_RS02410	COG1555	photosystem II stabilization
BK815_RS02415	COG2131	deaminase
BK815_RS02420	COG2333	competence protein COMEC
BK815_RS02420	COG0658	competence protein
BK815_RS02425	COG1466	dna polymerase III delta subunit
BK815_RS02430	COG0268	Binds directly to 16S ribosomal RNA
BK815_RS02435	COG0481	GTPase activity
BK815_RS02440	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BK815_RS02445	COG1420	regulation of RNA biosynthetic process
BK815_RS02450	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BK815_RS02455	COG0443	Heat shock 70 kDa protein
BK815_RS02460	COG0484	heat shock protein binding
BK815_RS02465	COG2264	protein methyltransferase activity
BK815_RS02470	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BK815_RS02475	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BK815_RS02485	COG4864	UPF0365 protein
BK815_RS02495	COG1702	phosphate starvation-inducible protein PhoH
BK815_RS02500	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BK815_RS02515	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BK815_RS02520	COG1381	Involved in DNA repair and RecF pathway recombination
BK815_RS02525	COG0423	glycine-tRNA ligase activity
BK815_RS02530	COG0517	IMP dehydrogenase activity
BK815_RS02535	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BK815_RS02545	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BK815_RS02550	COG2384	SAM-dependent methyltransferase
BK815_RS02555	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BK815_RS02560	COG0513	Belongs to the DEAD box helicase family
BK815_RS02565	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BK815_RS02570	COG1121	(ABC) transporter
BK815_RS02575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BK815_RS02585	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BK815_RS02590	COG0768	penicillin binding
BK815_RS02595	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BK815_RS02600	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BK815_RS02605	COG0705	Rhomboid family
BK815_RS02605	COG0457	Tetratricopeptide repeat
BK815_RS02610	COG4483	Protein conserved in bacteria
BK815_RS02625	COG1940	carbohydrate kinase activity
BK815_RS02630	COG0011	TIGRFAM Protein of
BK815_RS02635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BK815_RS02640	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BK815_RS02645	COG0582	viral genome integration into host DNA
BK815_RS02675	COG1395	domain, Protein
BK815_RS02710	COG0629	single-stranded DNA binding
BK815_RS02730	COG1484	DNA-dependent DNA replication
BK815_RS02915	COG5632	N-Acetylmuramoyl-L-alanine amidase
BK815_RS02915	COG1388	LysM domain
BK815_RS02945	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BK815_RS02950	COG1459	type II secretion system
BK815_RS02955	COG4537	Required for transformation and DNA binding
BK815_RS02980	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BK815_RS02985	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BK815_RS02990	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BK815_RS02995	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BK815_RS03000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BK815_RS03005	COG0095	Lipoate-protein ligase
BK815_RS03020	COG0006	proline dipeptidase activity
BK815_RS03025	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BK815_RS03030	COG0511	ligase activity, forming carbon-carbon bonds
BK815_RS03035	COG0439	Biotin carboxylase
BK815_RS03040	COG1302	Protein conserved in bacteria
BK815_RS03045	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BK815_RS03050	COG1570	exodeoxyribonuclease VII activity
BK815_RS03065	COG1438	arginine binding
BK815_RS03070	COG0497	DNA recombination
BK815_RS03075	COG0280	phosphate acetyltransferase
BK815_RS03080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BK815_RS03085	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BK815_RS03090	COG0022	dehydrogenase e1 component
BK815_RS03095	COG0508	dehydrogenase complex catalyzes the overall conversion of
BK815_RS03105	COG4129	membrane
BK815_RS03110	COG2195	Cleaves the N-terminal amino acid of tripeptides
BK815_RS03120	COG1609	Transcriptional regulator
BK815_RS03125	COG0366	Alpha amylase catalytic
BK815_RS03135	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BK815_RS03140	COG1234	tRNA 3'-trailer cleavage
BK815_RS03145	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BK815_RS03155	COG0667	Aldo Keto reductase
BK815_RS03160	COG0494	nUDIX hydrolase
BK815_RS03165	COG0735	belongs to the Fur family
BK815_RS03170	COG4974	Belongs to the 'phage' integrase family
BK815_RS03180	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BK815_RS03185	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BK815_RS03190	COG1187	pseudouridine synthase activity
BK815_RS03195	COG0745	RESPONSE REGULATOR receiver
BK815_RS03210	COG1141	Ferredoxin
BK815_RS03220	COG0514	ATP-dependent DNA helicase (RecQ)
BK815_RS03225	COG1388	LysM domain
BK815_RS03225	COG1388	LysM domain
BK815_RS03230	COG0492	ferredoxin-NADP+ reductase activity
BK815_RS03240	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BK815_RS03245	COG0539	negative regulation of cytoplasmic translation
BK815_RS03250	COG1160	GTP binding
BK815_RS03255	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BK815_RS03270	COG2226	methyltransferase
BK815_RS03275	COG0142	geranyltranstransferase activity
BK815_RS03280	COG0105	UTP biosynthetic process
BK815_RS03285	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BK815_RS03290	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BK815_RS03295	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BK815_RS03305	COG5582	Belongs to the UPF0302 family
BK815_RS03310	COG4347	Protein of unknown function (DUF1405)
BK815_RS03315	COG2738	Putative neutral zinc metallopeptidase
BK815_RS03320	COG1694	Mazg nucleotide pyrophosphohydrolase
BK815_RS03325	COG0438	transferase activity, transferring glycosyl groups
BK815_RS03330	COG0617	tRNA 3'-terminal CCA addition
BK815_RS03335	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BK815_RS03335	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BK815_RS03340	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BK815_RS03340	COG1199	ATP-dependent helicase activity
BK815_RS03345	COG0017	Asparaginyl-tRNA synthetase
BK815_RS03350	COG3935	DnaD domain protein
BK815_RS03355	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BK815_RS03365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BK815_RS03365	COG4499	WXG100 protein secretion system (Wss), protein YukC
BK815_RS03370	COG3331	DNA recombination
BK815_RS03380	COG4474	Belongs to the UPF0398 family
BK815_RS03395	COG0116	Belongs to the methyltransferase superfamily
BK815_RS03410	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BK815_RS03415	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BK815_RS03420	COG0328	RNA-DNA hybrid ribonuclease activity
BK815_RS03430	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BK815_RS03440	COG1413	lyase activity
BK815_RS03445	COG1413	lyase activity
BK815_RS03455	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BK815_RS03475	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BK815_RS03485	COG4479	Belongs to the UPF0346 family
BK815_RS03490	COG0793	Belongs to the peptidase S41A family
BK815_RS03500	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BK815_RS03505	COG0671	phosphoesterase, PA-phosphatase related
BK815_RS03510	COG0745	RESPONSE REGULATOR receiver
BK815_RS03515	COG5002	protein histidine kinase activity
BK815_RS03520	COG0567	Dehydrogenase, E1 component
BK815_RS03525	COG0508	dehydrogenase complex catalyzes the overall conversion of
BK815_RS03530	COG2207	Transcriptional regulator
BK815_RS03530	COG1917	Cupin 2, conserved barrel domain protein
BK815_RS03550	COG0673	inositol 2-dehydrogenase activity
BK815_RS03555	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BK815_RS03560	COG4152	abc transporter atp-binding protein
BK815_RS03585	COG0714	Associated with various cellular activities
BK815_RS03590	COG4548	von Willebrand factor, type A
BK815_RS03595	COG1114	Component of the transport system for branched-chain amino acids
BK815_RS03600	COG3853	Toxic anion resistance protein (TelA)
BK815_RS03610	COG1254	Belongs to the acylphosphatase family
BK815_RS03620	COG1278	Cold shock
BK815_RS03635	COG1473	amidohydrolase
BK815_RS03640	COG2171	N-acyltransferase activity
BK815_RS03645	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BK815_RS03650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BK815_RS03655	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BK815_RS03660	COG0527	aspartate kinase activity
BK815_RS03670	COG0488	(ABC) transporter
BK815_RS03675	COG2996	Protein conserved in bacteria
BK815_RS03680	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BK815_RS03685	COG0573	inorganic phosphate transmembrane transporter activity
BK815_RS03690	COG0581	inorganic phosphate transmembrane transporter activity
BK815_RS03695	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BK815_RS03700	COG0704	Plays a role in the regulation of phosphate uptake
BK815_RS03705	COG1164	Oligoendopeptidase f
BK815_RS03715	COG4607	ABC-type enterochelin transport system periplasmic component
BK815_RS03725	COG2348	transferase activity, transferring amino-acyl groups
BK815_RS03735	COG0159	tryptophan synthase activity
BK815_RS03740	COG0133	tryptophan synthase activity
BK815_RS03745	COG0135	phosphoribosylanthranilate isomerase activity
BK815_RS03750	COG0134	indole-3-glycerol-phosphate synthase activity
BK815_RS03755	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BK815_RS03760	COG0512	Glutamine amidotransferase of anthranilate synthase
BK815_RS03765	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BK815_RS03775	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BK815_RS03785	COG0463	Glycosyl transferase, family 2
BK815_RS03785	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BK815_RS03790	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BK815_RS03795	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BK815_RS03810	COG0438	transferase activity, transferring glycosyl groups
BK815_RS03855	COG2814	Major facilitator Superfamily
BK815_RS03865	COG1280	lysine exporter protein (LysE YggA)
BK815_RS03880	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BK815_RS03885	COG0346	lactoylglutathione lyase activity
BK815_RS03890	COG0346	lactoylglutathione lyase activity
BK815_RS03950	COG2223	nitrite transmembrane transporter activity
BK815_RS03955	COG3940	Belongs to the glycosyl hydrolase 43 family
BK815_RS03965	COG1733	regulation of RNA biosynthetic process
BK815_RS03970	COG1363	Peptidase, m42
BK815_RS03975	COG0287	Prephenate dehydrogenase
BK815_RS03980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BK815_RS04000	COG1879	ABC-type sugar transport system periplasmic component
BK815_RS04005	COG1172	Belongs to the binding-protein-dependent transport system permease family
BK815_RS04010	COG1129	ABC transporter
BK815_RS04015	COG1869	D-ribose catabolic process
BK815_RS04020	COG1609	Transcriptional regulator
BK815_RS04025	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BK815_RS04025	COG0392	lysyltransferase activity
BK815_RS04030	COG0628	permease
BK815_RS04035	COG3711	transcriptional antiterminator
BK815_RS04040	COG1115	amino acid carrier protein
BK815_RS04045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BK815_RS04055	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BK815_RS04060	COG4841	protein insertion into membrane
BK815_RS04065	COG0824	Thioesterase
BK815_RS04075	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BK815_RS04080	COG1970	mechanosensitive ion channel activity
BK815_RS04085	COG0419	ATPase involved in DNA repair
BK815_RS04090	COG0420	3'-5' exonuclease activity
BK815_RS04095	COG4846	Membrane protein involved in cytochrome C biogenesis
BK815_RS04105	COG3763	UPF0154 protein
BK815_RS04125	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BK815_RS04135	COG0516	GMP reductase activity
BK815_RS04140	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BK815_RS04145	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BK815_RS04150	COG0753	catalase activity
BK815_RS04155	COG0833	amino acid
BK815_RS04170	COG0083	homoserine kinase activity
BK815_RS04175	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BK815_RS04180	COG0460	homoserine dehydrogenase
BK815_RS04185	COG0527	aspartate kinase activity
BK815_RS04235	COG0730	response to heat
BK815_RS04240	COG1937	Protein conserved in bacteria
BK815_RS04245	COG2210	Belongs to the sulfur carrier protein TusA family
BK815_RS04250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BK815_RS04260	COG0789	Transcriptional regulator
BK815_RS04265	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BK815_RS04270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BK815_RS04275	COG0386	Belongs to the glutathione peroxidase family
BK815_RS04280	COG1923	regulation of RNA biosynthetic process
BK815_RS04285	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BK815_RS04295	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BK815_RS04300	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BK815_RS04305	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BK815_RS04310	COG1619	proteins homologs of microcin C7 resistance protein MccF
BK815_RS04315	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BK815_RS04320	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BK815_RS04325	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BK815_RS04335	COG4550	Control of competence regulator ComK, YlbF/YmcA
BK815_RS04340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BK815_RS04360	COG1013	pyruvate-flavodoxin oxidoreductase activity
BK815_RS04365	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BK815_RS04365	COG0674	pyruvate-flavodoxin oxidoreductase activity
BK815_RS04370	COG1692	metallophosphoesterase
BK815_RS04380	COG1418	mRNA catabolic process
BK815_RS04385	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BK815_RS04390	COG1546	Belongs to the CinA family
BK815_RS04390	COG1058	Belongs to the CinA family
BK815_RS04410	COG0300	oxidoreductase activity
BK815_RS04415	COG0612	Peptidase, M16
BK815_RS04420	COG0612	Peptidase, M16
BK815_RS04430	COG1674	ftsk spoiiie
BK815_RS04435	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BK815_RS04440	COG1185	polyribonucleotide nucleotidyltransferase activity
BK815_RS04450	COG0196	riboflavin kinase activity
BK815_RS04455	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BK815_RS04460	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BK815_RS04475	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BK815_RS04480	COG1358	cellular component organization or biogenesis
BK815_RS04485	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BK815_RS04490	COG0195	Participates in both transcription termination and antitermination
BK815_RS04495	COG0779	Required for maturation of 30S ribosomal subunits
BK815_RS04500	COG2176	DNA-directed DNA polymerase activity
BK815_RS04505	COG0442	prolyl-tRNA aminoacylation
BK815_RS04515	COG4589	Belongs to the CDS family
BK815_RS04520	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BK815_RS04525	COG0233	cytoplasmic translational termination
BK815_RS04530	COG0528	UMP kinase activity
BK815_RS04535	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BK815_RS04540	COG0052	Belongs to the universal ribosomal protein uS2 family
BK815_RS04545	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BK815_RS04550	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BK815_RS04555	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BK815_RS04560	COG4974	Belongs to the 'phage' integrase family
BK815_RS04565	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BK815_RS04570	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BK815_RS04575	COG0758	DNA mediated transformation
BK815_RS04585	COG0045	succinate-CoA ligase (ADP-forming) activity
BK815_RS04590	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BK815_RS04600	COG4485	Bacterial membrane protein, YfhO
BK815_RS04610	COG0335	large ribosomal subunit rRNA binding
BK815_RS04615	COG0336	Belongs to the RNA methyltransferase TrmD family
BK815_RS04620	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BK815_RS04625	COG0228	four-way junction DNA binding
BK815_RS04630	COG1028	Short-chain dehydrogenase reductase Sdr
BK815_RS04635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BK815_RS04640	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BK815_RS04645	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BK815_RS04650	COG0552	protein localization to endoplasmic reticulum
BK815_RS04655	COG1196	nuclear chromosome segregation
BK815_RS04660	COG0571	ribonuclease III activity
BK815_RS04665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BK815_RS04670	COG1028	Short-chain dehydrogenase reductase Sdr
BK815_RS04680	COG0416	fatty acid biosynthetic process
BK815_RS04685	COG1349	DNA-binding transcription factor activity
BK815_RS04700	COG1760	l-serine dehydratase
BK815_RS04705	COG1760	l-serine dehydratase
BK815_RS04710	COG1461	Dihydroxyacetone kinase
BK815_RS04715	COG1302	Protein conserved in bacteria
BK815_RS04720	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BK815_RS04725	COG1564	THIamine pyrophosphokinase
BK815_RS04730	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BK815_RS04735	COG1162	GTPase activity
BK815_RS04745	COG0631	protein serine/threonine phosphatase activity
BK815_RS04750	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BK815_RS04755	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BK815_RS04755	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BK815_RS04765	COG0242	peptide deformylase activity
BK815_RS04785	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BK815_RS04800	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BK815_RS04805	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BK815_RS04810	COG1758	RNA polymerase activity
BK815_RS04815	COG0194	GDP metabolic process
BK815_RS04820	COG1293	RNA-binding protein homologous to eukaryotic snRNP
BK815_RS04830	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BK815_RS04840	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BK815_RS04845	COG0284	orotidine-5'-phosphate decarboxylase activity
BK815_RS04850	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BK815_RS04855	COG0505	Belongs to the CarA family
BK815_RS04865	COG0540	Belongs to the ATCase OTCase family
BK815_RS04870	COG2233	PERMEase
BK815_RS04875	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BK815_RS04880	COG0564	pseudouridine synthase activity
BK815_RS04885	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BK815_RS04895	COG1522	sequence-specific DNA binding
BK815_RS04900	COG1388	LysM domain
BK815_RS04900	COG3942	CHAP domain
BK815_RS04910	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BK815_RS04915	COG3599	regulation of cell shape
BK815_RS04920	COG2302	S4 RNA-binding domain
BK815_RS04925	COG0762	integral membrane protein
BK815_RS04930	COG1799	cell septum assembly
BK815_RS04935	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BK815_RS04940	COG1496	oxidoreductase activity
BK815_RS04945	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BK815_RS04950	COG0849	cell division
BK815_RS04955	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BK815_RS04960	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BK815_RS04965	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BK815_RS04970	COG0768	penicillin binding
BK815_RS04975	COG4839	cell division protein FtsL
BK815_RS04980	COG0275	rRNA processing
BK815_RS04985	COG2001	Belongs to the MraZ family
BK815_RS04995	COG0454	-acetyltransferase
BK815_RS05000	COG1011	Hydrolase
BK815_RS05065	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BK815_RS05070	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BK815_RS05075	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BK815_RS05080	COG1053	succinate dehydrogenase
BK815_RS05085	COG2009	succinate dehydrogenase
BK815_RS05090	COG0322	excinuclease ABC activity
BK815_RS05095	COG3118	belongs to the thioredoxin family
BK815_RS05100	COG1193	negative regulation of DNA recombination
BK815_RS05105	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BK815_RS05105	COG1796	DNA polymerase
BK815_RS05115	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BK815_RS05120	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BK815_RS05125	COG0072	phenylalanine-tRNA ligase activity
BK815_RS05130	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BK815_RS05135	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BK815_RS05145	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BK815_RS05155	COG1323	Belongs to the UPF0348 family
BK815_RS05160	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BK815_RS05165	COG0742	ribosomal rna small subunit methyltransferase
BK815_RS05185	COG3679	Belongs to the UPF0342 family
BK815_RS05205	COG0109	protoheme IX farnesyltransferase activity
BK815_RS05210	COG1612	heme a metabolic process
BK815_RS05220	COG0772	Belongs to the SEDS family
BK815_RS05225	COG4838	Belongs to the UPF0358 family
BK815_RS05230	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BK815_RS05235	COG4896	Protein conserved in bacteria
BK815_RS05240	COG1217	gtp-binding protein TYPA
BK815_RS05250	COG0483	inositol monophosphate 1-phosphatase activity
BK815_RS05255	COG4493	Belongs to the UPF0637 family
BK815_RS05265	COG1914	H( )-stimulated, divalent metal cation uptake system
BK815_RS05275	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BK815_RS05280	COG1177	transmembrane transport
BK815_RS05285	COG1176	ABC-type spermidine putrescine transport system, permease component I
BK815_RS05290	COG3842	ATPase activity
BK815_RS05300	COG4476	Belongs to the UPF0223 family
BK815_RS05330	COG0242	peptide deformylase activity
BK815_RS05340	COG5503	Protein of unknown function (DUF1447)
BK815_RS05345	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BK815_RS05350	COG0569	domain protein
BK815_RS05355	COG1294	oxidase, subunit
BK815_RS05360	COG1271	oxidase subunit
BK815_RS05370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BK815_RS05375	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BK815_RS05385	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BK815_RS05400	COG4172	Belongs to the ABC transporter superfamily
BK815_RS05405	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BK815_RS05410	COG0151	Belongs to the GarS family
BK815_RS05415	COG0138	bifunctional purine biosynthesis protein purh
BK815_RS05425	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BK815_RS05435	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BK815_RS05445	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BK815_RS05450	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BK815_RS05455	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BK815_RS05460	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BK815_RS05465	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BK815_RS05475	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BK815_RS05480	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BK815_RS05485	COG1845	cytochrome c oxidase, subunit III
BK815_RS05490	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BK815_RS05505	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BK815_RS05510	COG1316	TRANSCRIPTIONal
BK815_RS05535	COG3594	Acyltransferase
BK815_RS05540	COG0436	Aminotransferase
BK815_RS05545	COG1846	Transcriptional regulator
BK815_RS05550	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BK815_RS05555	COG0596	Alpha beta hydrolase
BK815_RS05560	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BK815_RS05565	COG1169	isochorismate synthase
BK815_RS05570	COG1575	Belongs to the MenA family. Type 1 subfamily
BK815_RS05580	COG2314	TM2 domain
BK815_RS05600	COG4903	ComK protein
BK815_RS05615	COG4873	Protein conserved in bacteria
BK815_RS05625	COG0737	Belongs to the 5'-nucleotidase family
BK815_RS05630	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BK815_RS05635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BK815_RS05640	COG0861	Integral membrane protein TerC family
BK815_RS05645	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BK815_RS05655	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BK815_RS05660	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BK815_RS05665	COG2814	Major facilitator Superfamily
BK815_RS05670	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BK815_RS05675	COG2382	esterase
BK815_RS05680	COG1115	amino acid carrier protein
BK815_RS05685	COG0628	permease
BK815_RS05695	COG0475	glutathione-regulated potassium exporter activity
BK815_RS05695	COG0569	domain protein
BK815_RS05700	COG2239	Acts as a magnesium transporter
BK815_RS05705	COG0564	pseudouridine synthase activity
BK815_RS05710	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BK815_RS05715	COG2357	RelA SpoT domain protein
BK815_RS05725	COG4116	CYTH
BK815_RS05730	COG2346	COG2346, Truncated hemoglobins
BK815_RS05735	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BK815_RS05740	COG2910	NAD(P)H-binding
BK815_RS05745	COG1164	Oligoendopeptidase f
BK815_RS05755	COG4862	establishment of competence for transformation
BK815_RS05760	COG1393	Belongs to the ArsC family
BK815_RS05765	COG0180	Tryptophanyl-tRNA synthetase
BK815_RS05770	COG4166	transmembrane transport
BK815_RS05775	COG4608	Belongs to the ABC transporter superfamily
BK815_RS05780	COG0444	Belongs to the ABC transporter superfamily
BK815_RS05785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BK815_RS05790	COG0601	transmembrane transport
BK815_RS05810	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BK815_RS05820	COG0542	response to heat
BK815_RS05835	COG0561	phosphatase activity
BK815_RS05840	COG0446	pyridine nucleotide-disulphide oxidoreductase
BK815_RS05860	COG0179	Fumarylacetoacetate (FAA) hydrolase
BK815_RS05865	COG2311	Membrane
BK815_RS05870	COG1074	ATP-dependent DNA helicase activity
BK815_RS05875	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BK815_RS05890	COG0398	Pfam SNARE associated Golgi protein
BK815_RS05895	COG0166	Belongs to the GPI family
BK815_RS05900	COG0137	argininosuccinate synthase activity
BK815_RS05905	COG0165	Argininosuccinate lyase
BK815_RS05910	COG0584	glycerophosphoryl diester phosphodiesterase
BK815_RS05920	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BK815_RS05925	COG1902	pentaerythritol trinitrate reductase activity
BK815_RS05930	COG1098	S1 RNA binding domain
BK815_RS05935	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BK815_RS05945	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BK815_RS05945	COG2111	Na H antiporter
BK815_RS05950	COG2111	Na H antiporter
BK815_RS05955	COG1006	Multisubunit Na H antiporter MnhC subunit
BK815_RS05960	COG0651	ATP synthesis coupled electron transport
BK815_RS05965	COG1863	multisubunit Na H antiporter MnhE subunit
BK815_RS05970	COG2212	antiporter activity
BK815_RS05975	COG1320	monovalent cation:proton antiporter activity
BK815_RS05985	COG2050	protein possibly involved in aromatic compounds catabolism
BK815_RS05990	COG2056	Na+-H+ antiporter family
BK815_RS05995	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BK815_RS06000	COG1252	NADH dehydrogenase
BK815_RS06005	COG0316	Belongs to the HesB IscA family
BK815_RS06010	COG4844	belongs to the
BK815_RS06015	COG1252	NADH dehydrogenase
BK815_RS06020	COG4837	Protein of unknown function (DUF1462)
BK815_RS06025	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BK815_RS06030	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
BK815_RS06035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BK815_RS06040	COG1696	Membrane protein involved in D-alanine export
BK815_RS06045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BK815_RS06060	COG0647	UMP catabolic process
BK815_RS06065	COG2445	Protein of unknown function DUF86
BK815_RS06075	COG4470	Protein conserved in bacteria
BK815_RS06080	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BK815_RS06085	COG0737	Belongs to the 5'-nucleotidase family
BK815_RS06090	COG0730	response to heat
BK815_RS06095	COG1801	Protein of unknown function DUF72
BK815_RS06100	COG2070	2-Nitropropane dioxygenase
BK815_RS06105	COG1253	flavin adenine dinucleotide binding
BK815_RS06110	COG0719	Fe-S assembly protein
BK815_RS06115	COG0822	iron-sulfur transferase activity
BK815_RS06120	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BK815_RS06125	COG0719	Fe-S assembly protein
BK815_RS06130	COG0396	ATPase activity
BK815_RS06140	COG1253	flavin adenine dinucleotide binding
BK815_RS06145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BK815_RS06160	COG1464	Belongs to the NlpA lipoprotein family
BK815_RS06165	COG2011	ABC-type metal ion transport system permease component
BK815_RS06170	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BK815_RS06180	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BK815_RS06185	COG0509	glycine decarboxylation via glycine cleavage system
BK815_RS06190	COG1393	Belongs to the ArsC family
BK815_RS06195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BK815_RS06205	COG0710	3-dehydroquinate dehydratase activity
BK815_RS06210	COG1764	response to oxidative stress
BK815_RS06225	COG2851	Citrate transporter
BK815_RS06240	COG2314	TM2 domain
BK815_RS06270	COG2153	protein acetylation
BK815_RS06275	COG0346	lactoylglutathione lyase activity
BK815_RS06295	COG1288	antiporter activity
BK815_RS06320	COG0697	spore germination
BK815_RS06330	COG1418	mRNA catabolic process
BK815_RS06340	COG0456	acetyltransferase
BK815_RS06345	COG2814	Major facilitator Superfamily
BK815_RS06350	COG0563	adenylate kinase activity
BK815_RS06365	COG0346	lactoylglutathione lyase activity
BK815_RS06375	COG1611	Belongs to the LOG family
BK815_RS06385	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BK815_RS06390	COG0557	exoribonuclease II activity
BK815_RS06395	COG1647	Serine aminopeptidase, S33
BK815_RS06400	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BK815_RS06410	COG0148	phosphopyruvate hydratase activity
BK815_RS06415	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BK815_RS06420	COG0149	triose-phosphate isomerase activity
BK815_RS06425	COG0126	phosphoglycerate kinase activity
BK815_RS06455	COG1090	epimerase
BK815_RS06465	COG0740	serine-type endopeptidase activity
BK815_RS06485	COG1481	regulation of sporulation
BK815_RS06490	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BK815_RS06495	COG1660	Displays ATPase and GTPase activities
BK815_RS06510	COG0110	maltose O-acetyltransferase activity
BK815_RS06515	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BK815_RS06520	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BK815_RS06525	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BK815_RS06530	COG0556	nucleotide-excision repair
BK815_RS06545	COG1388	LysM domain
BK815_RS06545	COG3942	CHAP domain
BK815_RS06550	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BK815_RS06555	COG0653	protein targeting
BK815_RS06560	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BK815_RS06565	COG1040	competence protein
BK815_RS06570	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BK815_RS06580	COG1739	Uncharacterized protein family UPF0029
BK815_RS06585	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BK815_RS06590	COG2199	diguanylate cyclase activity
BK815_RS06605	COG2195	Cleaves the N-terminal amino acid of tripeptides
BK815_RS06610	COG1929	Belongs to the glycerate kinase type-1 family
BK815_RS06625	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BK815_RS06630	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BK815_RS06645	COG4607	ABC-type enterochelin transport system periplasmic component
BK815_RS06650	COG4604	ABC transporter, ATP-binding protein
BK815_RS06655	COG4605	iron ion homeostasis
BK815_RS06660	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BK815_RS06665	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BK815_RS06670	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BK815_RS06675	COG1780	Probably involved in ribonucleotide reductase function
BK815_RS06685	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BK815_RS06690	COG3104	oligopeptide transport
BK815_RS06695	COG3104	oligopeptide transport
BK815_RS06700	COG1597	lipid kinase activity
BK815_RS06710	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BK815_RS06715	COG1174	glycine betaine transport
BK815_RS06720	COG1125	glycine betaine transport
BK815_RS06720	COG0517	IMP dehydrogenase activity
BK815_RS06725	COG0514	ATP-dependent DNA helicase (RecQ)
BK815_RS06730	COG0488	(ABC) transporter
BK815_RS06740	COG1368	sulfuric ester hydrolase activity
BK815_RS06750	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BK815_RS06765	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BK815_RS06770	COG0512	Glutamine amidotransferase of anthranilate synthase
BK815_RS06775	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BK815_RS06780	COG0720	synthase
BK815_RS06785	COG0602	queuosine metabolic process
BK815_RS06800	COG0463	Glycosyl transferase, family 2
BK815_RS06805	COG0656	L-ascorbic acid biosynthetic process
BK815_RS06810	COG1253	flavin adenine dinucleotide binding
BK815_RS06815	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BK815_RS06820	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BK815_RS06820	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BK815_RS06820	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BK815_RS06825	COG1105	Belongs to the carbohydrate kinase PfkB family
BK815_RS06830	COG1349	DNA-binding transcription factor activity
BK815_RS06835	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BK815_RS06840	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BK815_RS06870	COG0039	L-malate dehydrogenase activity
BK815_RS06875	COG0586	Pfam SNARE associated Golgi protein
BK815_RS06885	COG4989	oxidoreductase activity
BK815_RS06900	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BK815_RS06905	COG4988	ABC transporter
BK815_RS06910	COG1968	undecaprenyl-diphosphatase activity
BK815_RS06920	COG1671	Belongs to the UPF0178 family
BK815_RS06925	COG1611	Belongs to the LOG family
BK815_RS06930	COG1279	arginine transmembrane transporter activity
BK815_RS06935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BK815_RS06940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BK815_RS06965	COG2814	Major facilitator Superfamily
BK815_RS06970	COG2839	Protein conserved in bacteria
BK815_RS06980	COG0583	DNA-binding transcription factor activity
BK815_RS06990	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BK815_RS07000	COG0217	transcriptional regulatory protein
BK815_RS07015	COG3942	CHAP domain
BK815_RS07015	COG1388	LysM domain
BK815_RS07020	COG0306	phosphate transporter
BK815_RS07025	COG1392	Phosphate transport regulator
BK815_RS07030	COG2205	protein histidine kinase activity
BK815_RS07035	COG0745	RESPONSE REGULATOR receiver
BK815_RS07040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BK815_RS07050	COG0657	acetylesterase activity
BK815_RS07055	COG3949	Membrane
BK815_RS07065	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
BK815_RS07070	COG1461	Dihydroxyacetone kinase
BK815_RS07075	COG2376	Dihydroxyacetone kinase
BK815_RS07080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BK815_RS07085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BK815_RS07090	COG1120	ATPase activity
BK815_RS07095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BK815_RS07105	COG1132	(ABC) transporter
BK815_RS07110	COG1686	Belongs to the peptidase S11 family
BK815_RS07115	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BK815_RS07125	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BK815_RS07130	COG1682	transport, permease protein
BK815_RS07135	COG1134	teichoic acid transport
BK815_RS07140	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
BK815_RS07160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BK815_RS07165	COG0803	Belongs to the bacterial solute-binding protein 9 family
BK815_RS07175	COG1320	monovalent cation:proton antiporter activity
BK815_RS07180	COG2212	antiporter activity
BK815_RS07185	COG1863	multisubunit Na H antiporter MnhE subunit
BK815_RS07190	COG0651	ATP synthesis coupled electron transport
BK815_RS07195	COG1006	Multisubunit Na H antiporter MnhC subunit
BK815_RS07200	COG2111	Na H antiporter
BK815_RS07245	COG0596	Alpha beta hydrolase
BK815_RS07260	COG2267	carboxylic ester hydrolase activity
BK815_RS07265	COG0546	phosphoglycolate phosphatase activity
BK815_RS07270	COG4139	cobalamin transport
BK815_RS07285	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BK815_RS07295	COG0018	arginyl-trna synthetase
BK815_RS07310	COG1078	dGTPase activity
BK815_RS07315	COG0456	acetyltransferase
BK815_RS07320	COG0655	NAD(P)H dehydrogenase (quinone) activity
BK815_RS07325	COG0667	Aldo Keto reductase
BK815_RS07330	COG4844	belongs to the
BK815_RS07335	COG1082	Xylose isomerase domain protein TIM barrel
BK815_RS07340	COG0673	inositol 2-dehydrogenase activity
BK815_RS07350	COG0673	inositol 2-dehydrogenase activity
BK815_RS07360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BK815_RS07360	COG1263	PTS System
BK815_RS07375	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BK815_RS07380	COG0095	Lipoate-protein ligase
BK815_RS07385	COG0280	phosphate acetyltransferase
BK815_RS07390	COG3253	May function as heme-dependent peroxidase
BK815_RS07410	COG2363	Small membrane protein
BK815_RS07420	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BK815_RS07450	COG0183	Belongs to the thiolase family
BK815_RS07455	COG0318	PFAM AMP-dependent synthetase and ligase
BK815_RS07465	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
BK815_RS07470	COG0363	glucosamine-6-phosphate deaminase activity
BK815_RS07480	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BK815_RS07485	COG1469	GTP cyclohydrolase I activity
BK815_RS07500	COG0431	NADPH-dependent FMN reductase
BK815_RS07505	COG0561	phosphatase activity
BK815_RS07515	COG1428	Deoxynucleoside kinase
BK815_RS07520	COG1428	Deoxynucleoside kinase
BK815_RS07530	COG0546	phosphoglycolate phosphatase activity
BK815_RS07540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BK815_RS07550	COG3239	Fatty acid desaturase
BK815_RS07555	COG2040	homocysteine
BK815_RS07560	COG0833	amino acid
BK815_RS07570	COG0010	Belongs to the arginase family
BK815_RS07575	COG1914	H( )-stimulated, divalent metal cation uptake system
BK815_RS07580	COG1069	ribulokinase activity
BK815_RS07585	COG1028	Short-chain dehydrogenase reductase Sdr
BK815_RS07590	COG1312	Catalyzes the dehydration of D-mannonate
BK815_RS07595	COG1904	glucuronate isomerase
BK815_RS07600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BK815_RS07615	COG0583	DNA-binding transcription factor activity
BK815_RS07645	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
BK815_RS07655	COG1028	Short-chain dehydrogenase reductase Sdr
BK815_RS07660	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BK815_RS07665	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BK815_RS07695	COG1473	amidohydrolase
BK815_RS07700	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BK815_RS07705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BK815_RS07710	COG0049	tRNA binding
BK815_RS07715	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BK815_RS07725	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BK815_RS07730	COG0085	RNA polymerase activity
BK815_RS07735	COG2813	Specifically methylates the guanine in position
BK815_RS07745	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BK815_RS07750	COG0081	regulation of translation
BK815_RS07755	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BK815_RS07760	COG0250	Participates in transcription elongation, termination and antitermination
BK815_RS07770	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BK815_RS07785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BK815_RS07790	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BK815_RS07795	COG0215	cysteine-tRNA ligase activity
BK815_RS07800	COG1045	serine acetyltransferase
BK815_RS07805	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BK815_RS07810	COG4956	integral membrane protein (PIN domain superfamily)
BK815_RS07815	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BK815_RS07820	COG0542	response to heat
BK815_RS07825	COG3869	Catalyzes the specific phosphorylation of arginine residues in
BK815_RS07830	COG3880	PFAM UvrB UvrC protein
BK815_RS07835	COG4463	regulation of RNA biosynthetic process
BK815_RS07840	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BK815_RS07845	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BK815_RS07850	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
BK815_RS07855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BK815_RS07940	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BK815_RS07950	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BK815_RS07970	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BK815_RS07975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BK815_RS07990	COG1098	S1 RNA binding domain
BK815_RS08000	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BK815_RS08005	COG3956	TIGRFAM MazG family protein
BK815_RS08010	COG2244	polysaccharide biosynthetic process
BK815_RS08015	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BK815_RS08020	COG0193	aminoacyl-tRNA hydrolase activity
BK815_RS08025	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BK815_RS08030	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BK815_RS08035	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BK815_RS08040	COG2088	sporulation resulting in formation of a cellular spore
BK815_RS08045	COG0251	oxidation-reduction process
BK815_RS08050	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BK815_RS08055	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BK815_RS08060	COG4466	Protein conserved in bacteria
BK815_RS08065	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BK815_RS08070	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BK815_RS08075	COG0084	hydrolase, TatD family'
BK815_RS08080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BK815_RS08080	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BK815_RS08085	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BK815_RS08090	COG2827	Endonuclease containing a URI domain
BK815_RS08095	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BK815_RS08100	COG4467	Involved in initiation control of chromosome replication
BK815_RS08105	COG1774	PSP1 C-terminal conserved region
BK815_RS08110	COG0470	DNA polymerase III
BK815_RS08115	COG3870	Protein conserved in bacteria
BK815_RS08120	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BK815_RS08125	COG1982	Orn Lys Arg decarboxylase major
BK815_RS08145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BK815_RS08150	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BK815_RS08155	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BK815_RS08170	COG2188	Transcriptional regulator
BK815_RS08175	COG0366	Alpha amylase catalytic
BK815_RS08180	COG1263	PTS System
BK815_RS08180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BK815_RS08190	COG0493	'glutamate synthase
BK815_RS08195	COG0070	glutamate synthase
BK815_RS08195	COG0069	glutamate synthase activity
BK815_RS08195	COG0067	glutamate synthase
BK815_RS08215	COG0004	ammonium transporteR
BK815_RS08230	COG3942	CHAP domain
BK815_RS08230	COG1388	LysM domain
BK815_RS08235	COG0129	dihydroxy-acid dehydratase activity
BK815_RS08240	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BK815_RS08245	COG0733	neurotransmitter:sodium symporter activity
BK815_RS08250	COG1114	Component of the transport system for branched-chain amino acids
BK815_RS08255	COG5646	InterPro IPR014922
BK815_RS08270	COG4195	phage-related replication protein
BK815_RS08275	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BK815_RS08285	COG2807	transmembrane transport
BK815_RS08300	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BK815_RS08305	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BK815_RS08310	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BK815_RS08315	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BK815_RS08320	COG3257	ureidoglycine aminohydrolase activity
BK815_RS08325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BK815_RS08335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BK815_RS08340	COG0406	alpha-ribazole phosphatase activity
BK815_RS08345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BK815_RS08350	COG1953	Uracil, thiamine, allantoin
BK815_RS08355	COG2508	Transcriptional regulator
BK815_RS08360	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BK815_RS08360	COG0456	acetyltransferase
BK815_RS08365	COG2814	Major facilitator Superfamily
BK815_RS08370	COG0583	DNA-binding transcription factor activity
BK815_RS08375	COG2814	Major facilitator Superfamily
BK815_RS08385	COG0519	Catalyzes the synthesis of GMP from XMP
BK815_RS08385	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BK815_RS08390	COG0516	GMP reductase activity
BK815_RS08390	COG0517	IMP dehydrogenase activity
BK815_RS08395	COG2233	PERMEase
BK815_RS08400	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BK815_RS08420	COG1823	symporter activity
BK815_RS08430	COG0778	Nitroreductase
BK815_RS08435	COG0753	catalase activity
BK815_RS08440	COG0450	alkyl hydroperoxide reductase
BK815_RS08445	COG3634	alkyl hydroperoxide reductase activity
BK815_RS08460	COG0406	alpha-ribazole phosphatase activity
BK815_RS08480	COG1280	lysine exporter protein (LysE YggA)
BK815_RS08485	COG2076	Multidrug Resistance protein
BK815_RS08490	COG2076	Multidrug Resistance protein
BK815_RS08500	COG0454	-acetyltransferase
BK815_RS08505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BK815_RS08515	COG4195	phage-related replication protein
BK815_RS08520	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BK815_RS08545	COG0360	Binds together with S18 to 16S ribosomal RNA
BK815_RS08555	COG0012	GTP binding
BK815_RS08560	COG4481	Protein conserved in bacteria
BK815_RS08565	COG0668	transmembrane transport
BK815_RS08570	COG5609	conserved protein (DUF2294)
BK815_RS08575	COG3002	Belongs to the UPF0753 family
BK815_RS08580	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BK815_RS08590	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
BK815_RS08600	COG1486	melibiose metabolic process
BK815_RS08605	COG2211	Major facilitator Superfamily
BK815_RS08610	COG1316	TRANSCRIPTIONal
BK815_RS08615	COG0772	Belongs to the SEDS family
BK815_RS08620	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BK815_RS08625	COG2814	Major facilitator Superfamily
BK815_RS08630	COG1473	amidohydrolase
BK815_RS08635	COG2814	Major facilitator Superfamily
BK815_RS08640	COG1733	regulation of RNA biosynthetic process
BK815_RS08650	COG0583	DNA-binding transcription factor activity
BK815_RS08665	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BK815_RS08670	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BK815_RS08675	COG0156	8-amino-7-oxononanoate synthase activity
BK815_RS08680	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
BK815_RS08690	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BK815_RS08695	COG1113	amino acid transport
BK815_RS08705	COG0640	Transcriptional regulator
BK815_RS08720	COG2814	Major facilitator Superfamily
BK815_RS08735	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BK815_RS08745	COG0529	Catalyzes the synthesis of activated sulfate
BK815_RS08750	COG2046	Belongs to the sulfate adenylyltransferase family
BK815_RS08755	COG0730	response to heat
BK815_RS08775	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BK815_RS08780	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BK815_RS08785	COG0175	sulfate reduction
BK815_RS08790	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BK815_RS08790	COG1017	nitric oxide dioxygenase activity
BK815_RS08795	COG1475	DNA binding
BK815_RS08800	COG0626	cystathionine gamma-synthase activity
BK815_RS08805	COG0626	cystathionine gamma-synthase activity
BK815_RS08810	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BK815_RS08810	COG0646	methionine synthase
BK815_RS08815	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BK815_RS08825	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BK815_RS08830	COG0183	Belongs to the thiolase family
BK815_RS08845	COG0318	PFAM AMP-dependent synthetase and ligase
BK815_RS08875	COG3759	membrane
BK815_RS08880	COG2808	Putative FMN-binding domain
BK815_RS08885	COG1846	Transcriptional regulator
BK815_RS08890	COG0531	amino acid
BK815_RS08895	COG0656	L-ascorbic acid biosynthetic process
BK815_RS08900	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BK815_RS08920	COG1082	Xylose isomerase domain protein TIM barrel
BK815_RS08930	COG0191	fructose-bisphosphate aldolase activity
BK815_RS08935	COG1082	Xylose isomerase domain protein TIM barrel
BK815_RS08940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BK815_RS08945	COG3718	enzyme involved in inositol metabolism
BK815_RS08950	COG1012	belongs to the aldehyde dehydrogenase family
BK815_RS08955	COG1349	DNA-binding transcription factor activity
BK815_RS08960	COG1082	Xylose isomerase domain protein TIM barrel
BK815_RS08965	COG1082	Xylose isomerase domain protein TIM barrel
BK815_RS08970	COG3962	Belongs to the TPP enzyme family
BK815_RS08975	COG2814	Major facilitator Superfamily
BK815_RS08995	COG3732	PTS system glucitol sorbitol-specific
BK815_RS09025	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BK815_RS09030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BK815_RS09045	COG0789	Transcriptional regulator
BK815_RS09045	COG4978	Transcriptional regulator
BK815_RS09050	COG1028	Short-chain dehydrogenase reductase Sdr
BK815_RS09060	COG3290	protein histidine kinase activity
BK815_RS09065	COG4565	transcriptional regulatory protein
BK815_RS09070	COG3493	citrate carrier protein
BK815_RS09080	COG1388	LysM domain
BK815_RS09085	COG2824	Alkylphosphonate utilization operon protein PhnA
BK815_RS09095	COG1621	beta-fructofuranosidase activity
BK815_RS09110	COG2271	Major facilitator Superfamily
BK815_RS09130	COG0436	Aminotransferase
BK815_RS09150	COG1876	peptidase activity
BK815_RS09160	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BK815_RS09170	COG1595	DNA-templated transcription, initiation
BK815_RS09175	COG4221	oxidoreductase activity
BK815_RS09190	COG0789	Transcriptional regulator
BK815_RS09200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BK815_RS09205	COG1733	regulation of RNA biosynthetic process
BK815_RS09225	COG0531	amino acid
BK815_RS09235	COG0583	DNA-binding transcription factor activity
BK815_RS09240	COG1846	Transcriptional regulator
BK815_RS09245	COG2807	transmembrane transport
BK815_RS09250	COG0583	DNA-binding transcription factor activity
BK815_RS09260	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BK815_RS09265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BK815_RS09280	COG1309	transcriptional regulator
BK815_RS09335	COG1131	(ABC) transporter
BK815_RS09355	COG1278	Cold shock
BK815_RS09360	COG0667	Aldo Keto reductase
BK815_RS09370	COG3152	Membrane
BK815_RS09390	COG1028	Short-chain dehydrogenase reductase Sdr
BK815_RS09400	COG1902	pentaerythritol trinitrate reductase activity
BK815_RS09420	COG1522	sequence-specific DNA binding
BK815_RS09425	COG1335	isochorismatase
BK815_RS09430	COG0384	phenazine biosynthesis protein PhzF
BK815_RS09450	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
BK815_RS09455	COG1733	regulation of RNA biosynthetic process
BK815_RS09460	COG2807	transmembrane transport
BK815_RS09465	COG0300	oxidoreductase activity
BK815_RS09470	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
BK815_RS09490	COG1966	Carbon starvation protein
BK815_RS09495	COG1475	DNA binding
BK815_RS09500	COG0357	Ribosomal RNA small subunit methyltransferase G
BK815_RS09505	COG0445	tRNA wobble uridine modification
BK815_RS09510	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BK815_RS09515	COG0594	ribonuclease P activity
BK815_RS09525	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BK815_RS09530	COG0592	DNA-directed DNA polymerase activity
BK815_RS09535	COG2501	S4 domain
BK815_RS09540	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BK815_RS09545	COG0187	DNA topoisomerase II activity
BK815_RS09555	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BK815_RS09560	COG2986	histidine ammonia-lyase
BK815_RS09565	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BK815_RS09570	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BK815_RS09590	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BK815_RS09595	COG0359	binds to the 23S rRNA
BK815_RS09600	COG0305	Participates in initiation and elongation during chromosome replication
BK815_RS09605	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BK815_RS09610	COG1819	glycosyl
BK815_RS09630	COG0477	Major facilitator Superfamily
BK815_RS09635	COG0745	RESPONSE REGULATOR receiver
BK815_RS09640	COG5002	protein histidine kinase activity
BK815_RS09645	COG4863	YycH protein
BK815_RS09655	COG2211	Major facilitator Superfamily
BK815_RS09665	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BK815_RS09670	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BK815_RS09755	COG1401	restriction endodeoxyribonuclease activity
BK815_RS09790	COG2814	Major facilitator Superfamily
BK815_RS09805	COG2268	Band 7 protein
BK815_RS09810	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BK815_RS09825	COG0693	protein deglycase activity
BK815_RS09830	COG1733	regulation of RNA biosynthetic process
BK815_RS09835	COG1733	regulation of RNA biosynthetic process
BK815_RS09840	COG1012	belongs to the aldehyde dehydrogenase family
BK815_RS09845	COG1064	alcohol dehydrogenase
BK815_RS09850	COG3711	transcriptional antiterminator
BK815_RS09855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BK815_RS09855	COG1263	PTS System
BK815_RS09860	COG2723	6-phospho-beta-galactosidase activity
BK815_RS09870	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BK815_RS09875	COG1063	alcohol dehydrogenase
BK815_RS09880	COG1063	alcohol dehydrogenase
BK815_RS09885	COG3775	system Galactitol-specific IIC component
BK815_RS09890	COG3414	Phosphotransferase system galactitol-specific IIB component
BK815_RS09905	COG3314	Sporulation integral membrane protein YlbJ
BK815_RS09910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BK815_RS09915	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BK815_RS09945	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BK815_RS09965	COG1131	(ABC) transporter
BK815_RS09975	COG0673	inositol 2-dehydrogenase activity
BK815_RS09980	COG1082	Xylose isomerase domain protein TIM barrel
BK815_RS09985	COG2814	Major facilitator Superfamily
BK815_RS09995	COG0577	efflux transmembrane transporter activity
BK815_RS10000	COG1136	(ABC) transporter
BK815_RS10005	COG1064	alcohol dehydrogenase
BK815_RS10030	COG1827	regulation of RNA biosynthetic process
BK815_RS10035	COG1104	cysteine desulfurase activity
BK815_RS10040	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BK815_RS10045	COG0157	Belongs to the NadC ModD family
BK815_RS10050	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BK815_RS10060	COG1028	Short-chain dehydrogenase reductase Sdr
BK815_RS10065	COG1388	LysM domain
BK815_RS10070	COG2318	DinB family
BK815_RS10075	COG1388	LysM domain
BK815_RS10085	COG0583	DNA-binding transcription factor activity
BK815_RS10090	COG0789	Transcriptional regulator
BK815_RS10095	COG2030	dehydratase
BK815_RS10100	COG1917	Cupin 2, conserved barrel domain protein
BK815_RS10105	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BK815_RS10110	COG1054	Belongs to the UPF0176 family
BK815_RS10115	COG3964	amidohydrolase
BK815_RS10130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BK815_RS10155	COG3192	ethanolamine utilization protein
BK815_RS10160	COG1028	Short-chain dehydrogenase reductase Sdr
BK815_RS10185	COG1511	domain protein
BK815_RS10210	COG1070	Carbohydrate kinase
BK815_RS10215	COG0352	thiamine-phosphate diphosphorylase activity
BK815_RS10230	COG2022	thiamine diphosphate biosynthetic process
BK815_RS10235	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BK815_RS10240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BK815_RS10245	COG0346	lactoylglutathione lyase activity
BK815_RS10255	COG2084	Dehydrogenase
BK815_RS10265	COG2610	gluconate transmembrane transporter activity
BK815_RS10270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BK815_RS10275	COG2814	Major facilitator Superfamily
BK815_RS10285	COG1737	Transcriptional regulator
BK815_RS10300	COG1695	Transcriptional regulator
BK815_RS10305	COG3479	Phenolic acid decarboxylase
BK815_RS10315	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BK815_RS10320	COG2011	ABC-type metal ion transport system permease component
BK815_RS10330	COG2329	Antibiotic biosynthesis monooxygenase
BK815_RS10340	COG0601	transmembrane transport
BK815_RS10345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BK815_RS10355	COG0405	Gamma-glutamyltransferase
BK815_RS10365	COG0653	protein targeting
BK815_RS10380	COG1942	4-Oxalocrotonate Tautomerase
BK815_RS10390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BK815_RS10395	COG1846	Transcriptional regulator
BK815_RS10410	COG1115	amino acid carrier protein
BK815_RS10420	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BK815_RS10425	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BK815_RS10430	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BK815_RS10435	COG0579	oxidoreductase
BK815_RS10465	COG0477	Major facilitator Superfamily
BK815_RS10470	COG2814	Major facilitator Superfamily
BK815_RS10475	COG0583	DNA-binding transcription factor activity
BK815_RS10480	COG0584	glycerophosphoryl diester phosphodiesterase
BK815_RS10490	COG0659	secondary active sulfate transmembrane transporter activity
BK815_RS10495	COG0589	response to stress
BK815_RS10515	COG1846	Transcriptional regulator
BK815_RS10525	COG3961	Belongs to the TPP enzyme family
BK815_RS10530	COG1609	Transcriptional regulator
BK815_RS10540	COG0235	Class ii aldolase
BK815_RS10545	COG2160	L-arabinose isomerase activity
BK815_RS10555	COG1846	Transcriptional regulator
BK815_RS10555	COG1940	carbohydrate kinase activity
BK815_RS10560	COG2115	Belongs to the xylose isomerase family
BK815_RS10565	COG1070	Carbohydrate kinase
BK815_RS10570	COG0477	Major facilitator Superfamily
BK815_RS10570	COG2814	Major facilitator Superfamily
BK815_RS10580	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
BK815_RS10585	COG1691	(AIR) carboxylase
BK815_RS10590	COG1606	tRNA processing
BK815_RS10595	COG3875	lactate racemase activity
BK815_RS10610	COG3835	regulator
BK815_RS10615	COG1113	amino acid transport
BK815_RS10620	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BK815_RS10620	COG0574	Belongs to the PEP-utilizing enzyme family
BK815_RS10625	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BK815_RS10635	COG0583	DNA-binding transcription factor activity
BK815_RS10640	COG0163	prenyltransferase activity
BK815_RS10660	COG1476	TRANSCRIPTIONal
BK815_RS10665	COG2807	transmembrane transport
BK815_RS10675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BK815_RS10680	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BK815_RS10685	COG1012	belongs to the aldehyde dehydrogenase family
BK815_RS10690	COG0531	amino acid
BK815_RS10695	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BK815_RS10700	COG3588	fructose-bisphosphate aldolase
BK815_RS10705	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BK815_RS10710	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BK815_RS10715	COG1510	regulation of RNA biosynthetic process
BK815_RS10720	COG1012	belongs to the aldehyde dehydrogenase family
BK815_RS10725	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
BK815_RS10730	COG0789	Transcriptional regulator
BK815_RS10745	COG0463	Glycosyl transferase, family 2
BK815_RS10745	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BK815_RS10755	COG0778	Nitroreductase
BK815_RS10760	COG1957	nucleoside hydrolase
BK815_RS10765	COG0477	Major facilitator Superfamily
BK815_RS10770	COG0531	amino acid
BK815_RS10775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BK815_RS10780	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BK815_RS10785	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BK815_RS10790	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BK815_RS10795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BK815_RS10800	COG0431	NADPH-dependent FMN reductase
BK815_RS10810	COG2814	Major facilitator Superfamily
BK815_RS10820	COG2190	(PTS) system
BK815_RS10820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BK815_RS10820	COG1263	PTS System
BK815_RS10825	COG0363	glucosamine-6-phosphate deaminase activity
BK815_RS10830	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BK815_RS10840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BK815_RS10845	COG0765	amino acid transport
BK815_RS10850	COG1126	abc transporter atp-binding protein
BK815_RS10855	COG1072	(Pantothenic acid kinase))
BK815_RS10860	COG3711	transcriptional antiterminator
BK815_RS10860	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BK815_RS10865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BK815_RS10875	COG3037	sugar-specific permease SgaT UlaA
BK815_RS10880	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BK815_RS10885	COG1464	Belongs to the NlpA lipoprotein family
BK815_RS10890	COG0039	L-malate dehydrogenase activity
BK815_RS10895	COG1482	cell wall glycoprotein biosynthetic process
BK815_RS10905	COG0523	cobalamin synthesis protein
BK815_RS10910	COG0523	cobalamin synthesis protein
BK815_RS10920	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BK815_RS10925	COG0626	cystathionine gamma-synthase activity
BK815_RS10950	COG0829	nickel cation binding
BK815_RS10955	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BK815_RS10960	COG0830	nickel cation binding
BK815_RS10965	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
BK815_RS10970	COG0804	urea catabolic process
BK815_RS10975	COG0832	Belongs to the urease beta subunit family
BK815_RS10980	COG0831	urea catabolic process
BK815_RS10985	COG4413	Urea transporter
BK815_RS10990	COG0747	negative chemotaxis
BK815_RS11030	COG0561	phosphatase activity
BK815_RS11040	COG0167	dihydroorotate dehydrogenase activity
BK815_RS11045	COG3001	Fructosamine kinase
BK815_RS11050	COG2814	Major facilitator Superfamily
BK815_RS11070	COG0640	Transcriptional regulator
BK815_RS11095	COG0697	spore germination
BK815_RS11100	COG1113	amino acid transport
BK815_RS11115	COG3189	MarR family transcriptional regulator
BK815_RS11130	COG1388	LysM domain
BK815_RS11135	COG0436	Aminotransferase
BK815_RS11145	COG2608	mercury ion transmembrane transporter activity
BK815_RS11150	COG2217	Heavy metal translocating P-type atpase
BK815_RS11155	COG0659	secondary active sulfate transmembrane transporter activity
BK815_RS11160	COG1136	(ABC) transporter
BK815_RS11165	COG0577	efflux transmembrane transporter activity
BK815_RS11170	COG1028	Short-chain dehydrogenase reductase Sdr
BK815_RS11180	COG0471	metal ion transport
BK815_RS11185	COG5505	Protein of unknown function (DUF819)
BK815_RS11200	COG4336	lyase activity
BK815_RS11210	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
BK815_RS11215	COG1012	belongs to the aldehyde dehydrogenase family
BK815_RS11225	COG2409	Drug exporters of the RND superfamily
BK815_RS11240	COG1473	amidohydrolase
BK815_RS11250	COG2819	hydrolase of the alpha beta superfamily
BK815_RS11260	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BK815_RS11265	COG3425	synthase
BK815_RS11270	COG0183	Belongs to the thiolase family
BK815_RS11280	COG3386	PFAM SMP-30 Gluconolaconase
BK815_RS11285	COG3942	CHAP domain
BK815_RS11290	COG1757	Na H antiporter
BK815_RS11295	COG0583	DNA-binding transcription factor activity
BK815_RS11310	COG0028	Belongs to the TPP enzyme family
BK815_RS11315	COG1288	antiporter activity
BK815_RS11320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BK815_RS11320	COG1263	PTS System
BK815_RS11320	COG2190	(PTS) system
BK815_RS11325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BK815_RS11335	COG2515	1-aminocyclopropane-1-carboxylate deaminase
BK815_RS11360	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BK815_RS11365	COG2843	Capsule synthesis protein
BK815_RS11375	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BK815_RS11380	COG1063	alcohol dehydrogenase
BK815_RS11385	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BK815_RS11405	COG1129	ABC transporter
BK815_RS11425	COG0671	phosphoesterase, PA-phosphatase related
BK815_RS11430	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BK815_RS11440	COG3764	Sortase (surface protein transpeptidase)
BK815_RS11445	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BK815_RS11450	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BK815_RS11460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BK815_RS11465	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BK815_RS11470	COG2249	NAD(P)H dehydrogenase (quinone) activity
BK815_RS11475	COG0561	phosphatase activity
BK815_RS11480	COG0778	Nitroreductase
BK815_RS11485	COG2514	catechol 2,3-dioxygenase activity
BK815_RS11505	COG1012	belongs to the aldehyde dehydrogenase family
BK815_RS11510	COG1846	Transcriptional regulator
BK815_RS11515	COG0346	lactoylglutathione lyase activity
BK815_RS11520	COG0346	lactoylglutathione lyase activity
BK815_RS11525	COG0400	carboxylic ester hydrolase activity
BK815_RS11535	COG0471	metal ion transport
BK815_RS11540	COG2211	Major facilitator Superfamily
BK815_RS11545	COG2207	Transcriptional regulator
BK815_RS11550	COG3250	beta-galactosidase activity
BK815_RS11560	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
BK815_RS11565	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BK815_RS11570	COG0586	Pfam SNARE associated Golgi protein
BK815_RS11575	COG2271	Major facilitator Superfamily
BK815_RS11585	COG3527	Alpha-acetolactate decarboxylase
BK815_RS11595	COG4876	unkown
BK815_RS11600	COG2357	RelA SpoT domain protein
BK815_RS11615	COG2610	gluconate transmembrane transporter activity
BK815_RS11620	COG3949	Membrane
BK815_RS11625	COG2207	Transcriptional regulator
BK815_RS11630	COG2211	Major facilitator Superfamily
BK815_RS11635	COG3250	beta-galactosidase activity
BK815_RS11650	COG4221	oxidoreductase activity
BK815_RS11680	COG0107	imidazoleglycerol-phosphate synthase activity
BK815_RS11685	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BK815_RS11690	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BK815_RS11695	COG0131	Imidazoleglycerol-phosphate dehydratase
BK815_RS11700	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BK815_RS11705	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BK815_RS11710	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BK815_RS11715	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BK815_RS11720	COG3048	D-serine ammonia-lyase activity
BK815_RS11725	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BK815_RS11735	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BK815_RS11740	COG1028	Short-chain dehydrogenase reductase Sdr
BK815_RS11745	COG0415	Belongs to the DNA photolyase family
BK815_RS11760	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
BK815_RS11765	COG0702	epimerase
BK815_RS11770	COG1363	Peptidase, m42
BK815_RS11780	COG0069	glutamate synthase activity
BK815_RS11790	COG4619	ABC transporter
BK815_RS11795	COG0390	transport system, permease component
BK815_RS11800	COG2814	Major facilitator Superfamily
BK815_RS11805	COG0531	amino acid
BK815_RS11810	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
BK815_RS11820	COG3246	L-lysine catabolic process to acetate
BK815_RS11825	COG1250	3-hydroxyacyl-CoA dehydrogenase
BK815_RS11840	COG1174	glycine betaine transport
BK815_RS11850	COG1174	glycine betaine transport
BK815_RS11860	COG1346	cytolysis
BK815_RS11870	COG3279	Response regulator of the LytR AlgR family
BK815_RS11875	COG3275	phosphorelay sensor kinase activity
BK815_RS11880	COG4187	Peptidase family M20/M25/M40
BK815_RS11890	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BK815_RS11915	COG2814	Major facilitator Superfamily
BK815_RS11925	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BK815_RS11930	COG1388	LysM domain
BK815_RS11935	COG0588	phosphoglycerate mutase activity
BK815_RS11940	COG2814	Major facilitator Superfamily
BK815_RS11965	COG3443	Belongs to the bacterial solute-binding protein 9 family
BK815_RS11965	COG0803	Belongs to the bacterial solute-binding protein 9 family
BK815_RS11985	COG2723	6-phospho-beta-galactosidase activity
BK815_RS11990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BK815_RS11990	COG1263	PTS System
BK815_RS11990	COG2190	(PTS) system
BK815_RS11995	COG2188	Transcriptional regulator
BK815_RS12000	COG1959	2 iron, 2 sulfur cluster binding
BK815_RS12005	COG2116	formate transmembrane transporter activity
BK815_RS12010	COG0454	-acetyltransferase
BK815_RS12020	COG0071	Belongs to the small heat shock protein (HSP20) family
BK815_RS12025	COG1846	Transcriptional regulator
BK815_RS12050	COG1263	PTS System
BK815_RS12050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BK815_RS12065	COG1511	domain protein
BK815_RS12070	COG1283	sodium-dependent phosphate transmembrane transporter activity
BK815_RS12075	COG1028	Short-chain dehydrogenase reductase Sdr
BK815_RS12080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BK815_RS12085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BK815_RS12090	COG1288	antiporter activity
BK815_RS12095	COG1349	DNA-binding transcription factor activity
BK815_RS12100	COG1063	alcohol dehydrogenase
BK815_RS12105	COG2376	Dihydroxyacetone kinase
BK815_RS12115	COG0698	ribose 5-phosphate isomerase
BK815_RS12135	COG0492	ferredoxin-NADP+ reductase activity
BK815_RS12145	COG2814	Major facilitator Superfamily
BK815_RS12150	COG0604	alcohol dehydrogenase
BK815_RS12170	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BK815_RS12175	COG1620	l-lactate permease
BK815_RS12180	COG0438	transferase activity, transferring glycosyl groups
BK815_RS12190	COG3850	Histidine kinase
BK815_RS12190	COG5002	protein histidine kinase activity
BK815_RS12195	COG0745	RESPONSE REGULATOR receiver
BK815_RS12200	COG0577	efflux transmembrane transporter activity
BK815_RS12205	COG1136	(ABC) transporter
BK815_RS12220	COG4640	response to antibiotic
BK815_RS12225	COG2814	Major facilitator Superfamily
BK815_RS12235	COG1566	PFAM secretion protein HlyD family protein
BK815_RS12240	COG2814	Major facilitator Superfamily
BK815_RS12265	COG0598	Magnesium transport protein CorA
BK815_RS12270	COG1304	FMN binding
BK815_RS12275	COG0786	glutamate:sodium symporter activity
BK815_RS12280	COG2094	Belongs to the DNA glycosylase MPG family
BK815_RS12285	COG3152	Membrane
BK815_RS12290	COG1069	ribulokinase activity
BK815_RS12295	COG4152	abc transporter atp-binding protein
BK815_RS12300	COG1668	transmembrane transport
BK815_RS12305	COG2017	converts alpha-aldose to the beta-anomer
BK815_RS12315	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BK815_RS12320	COG1266	CAAX protease self-immunity
BK815_RS12325	COG0010	Belongs to the arginase family
BK815_RS12330	COG0583	DNA-binding transcription factor activity
BK815_RS12335	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BK815_RS12340	COG1228	amidohydrolase
BK815_RS12345	COG0659	secondary active sulfate transmembrane transporter activity
BK815_RS12350	COG1473	amidohydrolase
BK815_RS12355	COG1028	Short-chain dehydrogenase reductase Sdr
BK815_RS12370	COG1737	Transcriptional regulator
BK815_RS12375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BK815_RS12375	COG1263	PTS System
BK815_RS12385	COG0385	Bile acid
BK815_RS12390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BK815_RS12415	COG1113	amino acid transport
BK815_RS12420	COG1785	Belongs to the alkaline phosphatase family
BK815_RS12425	COG1737	Transcriptional regulator
BK815_RS12430	COG1263	PTS System
BK815_RS12430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BK815_RS12435	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BK815_RS12450	COG1266	CAAX protease self-immunity
BK815_RS12460	COG0483	inositol monophosphate 1-phosphatase activity
BK815_RS12465	COG1316	TRANSCRIPTIONal
BK815_RS12470	COG3383	formate dehydrogenase (NAD+) activity
BK815_RS12495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BK815_RS12500	COG2076	Multidrug Resistance protein
BK815_RS12505	COG2076	Multidrug Resistance protein
BK815_RS12510	COG3942	CHAP domain
BK815_RS12520	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BK815_RS12525	COG1757	Na H antiporter
BK815_RS12530	COG3942	CHAP domain
BK815_RS12550	COG1960	acyl-CoA dehydrogenase activity
BK815_RS12555	COG2843	Capsule synthesis protein
BK815_RS12565	COG1268	BioY protein
BK815_RS12575	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BK815_RS12580	COG1609	Transcriptional regulator
BK815_RS12585	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BK815_RS12590	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BK815_RS12595	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
BK815_RS12600	COG0725	ABC transporter, periplasmic molybdate-binding protein
BK815_RS12605	COG4149	molybdate abc transporter
BK815_RS12610	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BK815_RS12615	COG1510	regulation of RNA biosynthetic process
BK815_RS12620	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BK815_RS12625	COG0521	Mo-molybdopterin cofactor biosynthetic process
BK815_RS12630	COG0315	cyclic pyranopterin monophosphate synthase activity
BK815_RS12640	COG1763	Mo-molybdopterin cofactor biosynthetic process
BK815_RS12655	COG0746	molybdenum cofactor guanylyltransferase activity
BK815_RS12660	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BK815_RS12670	COG2814	Major facilitator Superfamily
BK815_RS12690	COG2348	transferase activity, transferring amino-acyl groups
BK815_RS12695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BK815_RS12715	COG4975	Glucose uptake
BK815_RS12725	COG0551	DNA topoisomerase type I activity
BK815_RS12725	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BK815_RS12730	COG2252	PERMEase
BK815_RS12745	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BK815_RS12750	COG0088	Forms part of the polypeptide exit tunnel
BK815_RS12755	COG0089	rRNA binding
BK815_RS12760	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BK815_RS12765	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BK815_RS12770	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BK815_RS12775	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BK815_RS12780	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BK815_RS12785	COG0255	Belongs to the universal ribosomal protein uL29 family
BK815_RS12790	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BK815_RS12795	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BK815_RS12800	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BK815_RS12805	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BK815_RS12810	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BK815_RS12815	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BK815_RS12820	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BK815_RS12825	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BK815_RS12830	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BK815_RS12835	COG1841	ribosomal large subunit assembly
BK815_RS12845	COG0201	protein transport
BK815_RS12850	COG0563	adenylate kinase activity
BK815_RS12860	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BK815_RS12865	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BK815_RS12870	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BK815_RS12875	COG0202	RNA polymerase activity
BK815_RS12880	COG0203	ribosomal protein L17
BK815_RS12885	COG1122	ATPase activity
BK815_RS12890	COG1122	ATPase activity
BK815_RS12900	COG0101	tRNA pseudouridine synthase activity
BK815_RS12905	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BK815_RS12910	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BK815_RS12920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BK815_RS12925	COG2130	NADP-dependent
BK815_RS12930	COG0604	alcohol dehydrogenase
BK815_RS12935	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BK815_RS12950	COG1302	Protein conserved in bacteria
BK815_RS12955	COG4264	IucA IucC family
BK815_RS12960	COG2814	Major facilitator Superfamily
BK815_RS12965	COG4264	IucA IucC family
BK815_RS12970	COG3457	Alanine racemase
BK815_RS12975	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BK815_RS12980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BK815_RS12985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BK815_RS12990	COG3314	Sporulation integral membrane protein YlbJ
BK815_RS12995	COG2329	Antibiotic biosynthesis monooxygenase
BK815_RS13000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BK815_RS13005	COG0531	amino acid
BK815_RS13015	COG1988	membrane-bound metal-dependent
BK815_RS13020	COG4284	Utp--glucose-1-phosphate uridylyltransferase
BK815_RS13025	COG1272	protein, Hemolysin III
BK815_RS13040	COG2814	Major facilitator Superfamily
BK815_RS13045	COG0489	protein tyrosine kinase activity
BK815_RS13100	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BK815_RS13110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate