locus-tag	class	description
MUA21_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MUA21_RS00010	COG0592	DNA-directed DNA polymerase activity
MUA21_RS00015	COG2501	S4 domain
MUA21_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MUA21_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MUA21_RS00045	COG2986	histidine ammonia-lyase
MUA21_RS00050	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MUA21_RS00055	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
MUA21_RS00065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MUA21_RS00075	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
MUA21_RS00080	COG0359	binds to the 23S rRNA
MUA21_RS00085	COG0305	Participates in initiation and elongation during chromosome replication
MUA21_RS00090	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MUA21_RS00095	COG1819	glycosyl
MUA21_RS00110	COG0745	RESPONSE REGULATOR receiver
MUA21_RS00115	COG5002	protein histidine kinase activity
MUA21_RS00130	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MUA21_RS00135	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MUA21_RS00160	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MUA21_RS00180	COG2003	Belongs to the UPF0758 family
MUA21_RS00220	COG1136	(ABC) transporter
MUA21_RS00225	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MUA21_RS00240	COG0702	epimerase
MUA21_RS00245	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
MUA21_RS00280	COG0415	Belongs to the DNA photolyase family
MUA21_RS00305	COG1401	restriction endodeoxyribonuclease activity
MUA21_RS00315	COG2813	Specifically methylates the guanine in position
MUA21_RS00340	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
MUA21_RS00360	COG1959	2 iron, 2 sulfur cluster binding
MUA21_RS00365	COG2910	NAD(P)H-binding
MUA21_RS00400	COG1705	Flagellar rod assembly protein muramidase FlgJ
MUA21_RS00400	COG3942	CHAP domain
MUA21_RS00415	COG4195	phage-related replication protein
MUA21_RS00420	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
MUA21_RS00440	COG0668	transmembrane transport
MUA21_RS00460	COG1737	Transcriptional regulator
MUA21_RS00465	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MUA21_RS00470	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MUA21_RS00475	COG1447	Phosphotransferase system cellobiose-specific component IIA
MUA21_RS00485	COG1063	alcohol dehydrogenase
MUA21_RS00515	COG0706	membrane insertase activity
MUA21_RS00535	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MUA21_RS00545	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
MUA21_RS00550	COG0471	metal ion transport
MUA21_RS00555	COG1028	Short-chain dehydrogenase reductase Sdr
MUA21_RS00565	COG3711	transcriptional antiterminator
MUA21_RS00570	COG2190	(PTS) system
MUA21_RS00570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MUA21_RS00570	COG1263	PTS System
MUA21_RS00575	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MUA21_RS00580	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MUA21_RS00585	COG0438	transferase activity, transferring glycosyl groups
MUA21_RS00590	COG1876	peptidase activity
MUA21_RS00600	COG0402	S-adenosylhomocysteine deaminase activity
MUA21_RS00610	COG0640	Transcriptional regulator
MUA21_RS00620	COG1511	domain protein
MUA21_RS00625	COG2207	Transcriptional regulator
MUA21_RS00630	COG2211	Major facilitator Superfamily
MUA21_RS00635	COG3250	beta-galactosidase activity
MUA21_RS00645	COG3655	Transcriptional regulator
MUA21_RS00660	COG0579	oxidoreductase
MUA21_RS00665	COG1028	Short-chain dehydrogenase reductase Sdr
MUA21_RS00670	COG0471	metal ion transport
MUA21_RS00675	COG2318	DinB family
MUA21_RS00680	COG1388	LysM domain
MUA21_RS00685	COG0564	pseudouridine synthase activity
MUA21_RS00690	COG1388	LysM domain
MUA21_RS00710	COG0129	dihydroxy-acid dehydratase activity
MUA21_RS00720	COG3942	CHAP domain
MUA21_RS00720	COG1388	LysM domain
MUA21_RS00730	COG1051	belongs to the nudix hydrolase family
MUA21_RS00755	COG0583	DNA-binding transcription factor activity
MUA21_RS00760	COG0069	glutamate synthase activity
MUA21_RS00760	COG0070	glutamate synthase
MUA21_RS00760	COG0067	glutamate synthase
MUA21_RS00765	COG0493	'glutamate synthase
MUA21_RS00775	COG1263	PTS System
MUA21_RS00775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MUA21_RS00780	COG0366	Alpha amylase catalytic
MUA21_RS00785	COG2188	Transcriptional regulator
MUA21_RS00795	COG3153	acetyltransferase
MUA21_RS00800	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MUA21_RS00805	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MUA21_RS00810	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MUA21_RS00830	COG1982	Orn Lys Arg decarboxylase major
MUA21_RS00835	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MUA21_RS00840	COG3870	Protein conserved in bacteria
MUA21_RS00845	COG0470	DNA polymerase III
MUA21_RS00855	COG4467	Involved in initiation control of chromosome replication
MUA21_RS00860	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MUA21_RS00865	COG2827	Endonuclease containing a URI domain
MUA21_RS00870	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MUA21_RS00875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MUA21_RS00875	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MUA21_RS00880	COG0084	hydrolase, TatD family'
MUA21_RS00885	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MUA21_RS00890	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MUA21_RS00895	COG4466	Protein conserved in bacteria
MUA21_RS00900	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MUA21_RS00905	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MUA21_RS00910	COG0251	oxidation-reduction process
MUA21_RS00915	COG2088	sporulation resulting in formation of a cellular spore
MUA21_RS00920	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MUA21_RS00925	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MUA21_RS00930	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MUA21_RS00935	COG0193	aminoacyl-tRNA hydrolase activity
MUA21_RS00940	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MUA21_RS00945	COG2244	polysaccharide biosynthetic process
MUA21_RS00950	COG3956	TIGRFAM MazG family protein
MUA21_RS00955	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MUA21_RS00965	COG1098	S1 RNA binding domain
MUA21_RS00970	COG0037	tRNA processing
MUA21_RS00980	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MUA21_RS00985	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MUA21_RS01005	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MUA21_RS01010	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MUA21_RS01080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MUA21_RS01085	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MUA21_RS01090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MUA21_RS01095	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MUA21_RS01100	COG4463	regulation of RNA biosynthetic process
MUA21_RS01105	COG3880	PFAM UvrB UvrC protein
MUA21_RS01110	COG3869	Catalyzes the specific phosphorylation of arginine residues in
MUA21_RS01115	COG0542	response to heat
MUA21_RS01120	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MUA21_RS01125	COG4956	integral membrane protein (PIN domain superfamily)
MUA21_RS01130	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MUA21_RS01135	COG1045	serine acetyltransferase
MUA21_RS01140	COG0215	cysteine-tRNA ligase activity
MUA21_RS01145	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MUA21_RS01150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MUA21_RS01165	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MUA21_RS01170	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MUA21_RS01175	COG0250	Participates in transcription elongation, termination and antitermination
MUA21_RS01180	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MUA21_RS01185	COG0081	regulation of translation
MUA21_RS01190	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MUA21_RS01195	COG0222	ribosome binding
MUA21_RS01200	COG2813	Specifically methylates the guanine in position
MUA21_RS01205	COG0085	RNA polymerase activity
MUA21_RS01210	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MUA21_RS01220	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MUA21_RS01225	COG0049	tRNA binding
MUA21_RS01230	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MUA21_RS01235	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MUA21_RS01240	COG1473	amidohydrolase
MUA21_RS01265	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MUA21_RS01270	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
MUA21_RS01290	COG0463	Glycosyl transferase, family 2
MUA21_RS01290	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MUA21_RS01325	COG0583	DNA-binding transcription factor activity
MUA21_RS01340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MUA21_RS01360	COG1904	glucuronate isomerase
MUA21_RS01365	COG1312	Catalyzes the dehydration of D-mannonate
MUA21_RS01370	COG1028	Short-chain dehydrogenase reductase Sdr
MUA21_RS01380	COG3949	Membrane
MUA21_RS01390	COG0010	Belongs to the arginase family
MUA21_RS01400	COG1113	amino acid transport
MUA21_RS01410	COG2814	Major facilitator Superfamily
MUA21_RS01415	COG0583	DNA-binding transcription factor activity
MUA21_RS01425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MUA21_RS01430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MUA21_RS01435	COG4297	protein containing double-stranded beta helix domain
MUA21_RS01450	COG1428	Deoxynucleoside kinase
MUA21_RS01455	COG1428	Deoxynucleoside kinase
MUA21_RS01465	COG0561	phosphatase activity
MUA21_RS01470	COG0431	NADPH-dependent FMN reductase
MUA21_RS01485	COG1469	GTP cyclohydrolase I activity
MUA21_RS01490	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MUA21_RS01500	COG0363	glucosamine-6-phosphate deaminase activity
MUA21_RS01505	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
MUA21_RS01515	COG0463	Glycosyl transferase, family 2
MUA21_RS01515	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MUA21_RS01520	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MUA21_RS01520	COG0463	Glycosyl transferase, family 2
MUA21_RS01530	COG2755	lipolytic protein G-D-S-L family
MUA21_RS01530	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MUA21_RS01545	COG0318	PFAM AMP-dependent synthetase and ligase
MUA21_RS01550	COG0183	Belongs to the thiolase family
MUA21_RS01590	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MUA21_RS01600	COG2363	Small membrane protein
MUA21_RS01620	COG3253	May function as heme-dependent peroxidase
MUA21_RS01625	COG0280	phosphate acetyltransferase
MUA21_RS01630	COG0095	Lipoate-protein ligase
MUA21_RS01635	COG0083	homoserine kinase activity
MUA21_RS01650	COG4844	belongs to the
MUA21_RS01655	COG1028	Short-chain dehydrogenase reductase Sdr
MUA21_RS01675	COG0667	Aldo Keto reductase
MUA21_RS01680	COG0655	NAD(P)H dehydrogenase (quinone) activity
MUA21_RS01685	COG0456	acetyltransferase
MUA21_RS01690	COG1078	dGTPase activity
MUA21_RS01705	COG0018	arginyl-trna synthetase
MUA21_RS01710	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MUA21_RS01715	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MUA21_RS01720	COG4139	cobalamin transport
MUA21_RS01785	COG2111	Na H antiporter
MUA21_RS01785	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MUA21_RS01790	COG2111	Na H antiporter
MUA21_RS01795	COG1006	Multisubunit Na H antiporter MnhC subunit
MUA21_RS01800	COG0651	ATP synthesis coupled electron transport
MUA21_RS01805	COG1863	multisubunit Na H antiporter MnhE subunit
MUA21_RS01810	COG2212	antiporter activity
MUA21_RS01815	COG1320	monovalent cation:proton antiporter activity
MUA21_RS01825	COG0803	Belongs to the bacterial solute-binding protein 9 family
MUA21_RS01830	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MUA21_RS01835	COG1121	(ABC) transporter
MUA21_RS01840	COG1321	iron dependent repressor
MUA21_RS01850	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
MUA21_RS01855	COG1134	teichoic acid transport
MUA21_RS01860	COG1682	transport, permease protein
MUA21_RS01865	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MUA21_RS01875	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MUA21_RS01880	COG1686	Belongs to the peptidase S11 family
MUA21_RS01885	COG1132	(ABC) transporter
MUA21_RS01890	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MUA21_RS01895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MUA21_RS01900	COG1120	ATPase activity
MUA21_RS01905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MUA21_RS01910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MUA21_RS01915	COG2376	Dihydroxyacetone kinase
MUA21_RS01920	COG1461	Dihydroxyacetone kinase
MUA21_RS01925	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
MUA21_RS01935	COG3949	Membrane
MUA21_RS01940	COG0657	acetylesterase activity
MUA21_RS01950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MUA21_RS01955	COG0745	RESPONSE REGULATOR receiver
MUA21_RS01960	COG2205	protein histidine kinase activity
MUA21_RS01965	COG1392	Phosphate transport regulator
MUA21_RS01970	COG0306	phosphate transporter
MUA21_RS01975	COG3942	CHAP domain
MUA21_RS01975	COG1388	LysM domain
MUA21_RS01995	COG0217	transcriptional regulatory protein
MUA21_RS02005	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MUA21_RS02015	COG0583	DNA-binding transcription factor activity
MUA21_RS02025	COG2839	Protein conserved in bacteria
MUA21_RS02030	COG2814	Major facilitator Superfamily
MUA21_RS02055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MUA21_RS02075	COG1279	arginine transmembrane transporter activity
MUA21_RS02080	COG1611	Belongs to the LOG family
MUA21_RS02085	COG1671	Belongs to the UPF0178 family
MUA21_RS02095	COG1968	undecaprenyl-diphosphatase activity
MUA21_RS02100	COG4988	ABC transporter
MUA21_RS02105	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MUA21_RS02120	COG4989	oxidoreductase activity
MUA21_RS02130	COG0586	Pfam SNARE associated Golgi protein
MUA21_RS02135	COG0039	L-malate dehydrogenase activity
MUA21_RS02165	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MUA21_RS02170	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MUA21_RS02175	COG1349	DNA-binding transcription factor activity
MUA21_RS02180	COG1105	Belongs to the carbohydrate kinase PfkB family
MUA21_RS02185	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MUA21_RS02185	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MUA21_RS02185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MUA21_RS02190	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MUA21_RS02195	COG1253	flavin adenine dinucleotide binding
MUA21_RS02200	COG0656	L-ascorbic acid biosynthetic process
MUA21_RS02205	COG0463	Glycosyl transferase, family 2
MUA21_RS02220	COG0602	queuosine metabolic process
MUA21_RS02225	COG0720	synthase
MUA21_RS02230	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MUA21_RS02235	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MUA21_RS02235	COG0512	Glutamine amidotransferase of anthranilate synthase
MUA21_RS02255	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MUA21_RS02265	COG1368	sulfuric ester hydrolase activity
MUA21_RS02275	COG0488	(ABC) transporter
MUA21_RS02280	COG0514	ATP-dependent DNA helicase (RecQ)
MUA21_RS02285	COG0517	IMP dehydrogenase activity
MUA21_RS02285	COG1125	glycine betaine transport
MUA21_RS02290	COG1174	glycine betaine transport
MUA21_RS02295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MUA21_RS02305	COG1597	lipid kinase activity
MUA21_RS02310	COG3104	oligopeptide transport
MUA21_RS02315	COG3104	oligopeptide transport
MUA21_RS02320	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MUA21_RS02330	COG1780	Probably involved in ribonucleotide reductase function
MUA21_RS02335	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MUA21_RS02340	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MUA21_RS02345	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MUA21_RS02350	COG4605	iron ion homeostasis
MUA21_RS02355	COG4604	ABC transporter, ATP-binding protein
MUA21_RS02360	COG4607	ABC-type enterochelin transport system periplasmic component
MUA21_RS02375	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MUA21_RS02395	COG1929	Belongs to the glycerate kinase type-1 family
MUA21_RS02405	COG2195	Cleaves the N-terminal amino acid of tripeptides
MUA21_RS02420	COG2199	diguanylate cyclase activity
MUA21_RS02425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MUA21_RS02430	COG1739	Uncharacterized protein family UPF0029
MUA21_RS02440	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
MUA21_RS02445	COG1040	competence protein
MUA21_RS02450	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MUA21_RS02455	COG0653	protein targeting
MUA21_RS02465	COG3942	CHAP domain
MUA21_RS02465	COG1388	LysM domain
MUA21_RS02480	COG0556	nucleotide-excision repair
MUA21_RS02485	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MUA21_RS02490	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MUA21_RS02495	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MUA21_RS02500	COG0110	maltose O-acetyltransferase activity
MUA21_RS02510	COG0492	ferredoxin-NADP+ reductase activity
MUA21_RS02515	COG1660	Displays ATPase and GTPase activities
MUA21_RS02520	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MUA21_RS02525	COG1481	regulation of sporulation
MUA21_RS02530	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MUA21_RS02540	COG0740	serine-type endopeptidase activity
MUA21_RS02550	COG1090	epimerase
MUA21_RS02575	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MUA21_RS02580	COG0126	phosphoglycerate kinase activity
MUA21_RS02585	COG0149	triose-phosphate isomerase activity
MUA21_RS02590	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MUA21_RS02595	COG0148	phosphopyruvate hydratase activity
MUA21_RS02605	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MUA21_RS02610	COG1647	Serine aminopeptidase, S33
MUA21_RS02615	COG0557	exoribonuclease II activity
MUA21_RS02620	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MUA21_RS02800	COG0346	lactoylglutathione lyase activity
MUA21_RS02875	COG1288	antiporter activity
MUA21_RS02900	COG0346	lactoylglutathione lyase activity
MUA21_RS02945	COG2314	TM2 domain
MUA21_RS02960	COG2851	Citrate transporter
MUA21_RS02975	COG1764	response to oxidative stress
MUA21_RS02980	COG0710	3-dehydroquinate dehydratase activity
MUA21_RS02985	COG0778	Nitroreductase
MUA21_RS02990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MUA21_RS02995	COG1393	Belongs to the ArsC family
MUA21_RS03000	COG0509	glycine decarboxylation via glycine cleavage system
MUA21_RS03005	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MUA21_RS03010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MUA21_RS03015	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MUA21_RS03020	COG2011	ABC-type metal ion transport system permease component
MUA21_RS03025	COG1464	Belongs to the NlpA lipoprotein family
MUA21_RS03085	COG3728	DNA packaging
MUA21_RS03085	COG5484	DNA packaging
MUA21_RS03115	COG0693	protein deglycase activity
MUA21_RS03145	COG0396	ATPase activity
MUA21_RS03150	COG0719	Fe-S assembly protein
MUA21_RS03160	COG0822	iron-sulfur transferase activity
MUA21_RS03165	COG0719	Fe-S assembly protein
MUA21_RS03170	COG1253	flavin adenine dinucleotide binding
MUA21_RS03175	COG2070	2-Nitropropane dioxygenase
MUA21_RS03180	COG1801	Protein of unknown function DUF72
MUA21_RS03185	COG0730	response to heat
MUA21_RS03190	COG0737	Belongs to the 5'-nucleotidase family
MUA21_RS03195	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MUA21_RS03200	COG4470	Protein conserved in bacteria
MUA21_RS03210	COG2445	Protein of unknown function DUF86
MUA21_RS03215	COG0647	UMP catabolic process
MUA21_RS03230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MUA21_RS03235	COG1696	Membrane protein involved in D-alanine export
MUA21_RS03240	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MUA21_RS03245	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MUA21_RS03250	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
MUA21_RS03255	COG4837	Protein of unknown function (DUF1462)
MUA21_RS03260	COG1252	NADH dehydrogenase
MUA21_RS03265	COG4844	belongs to the
MUA21_RS03270	COG0316	Belongs to the HesB IscA family
MUA21_RS03275	COG1252	NADH dehydrogenase
MUA21_RS03280	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MUA21_RS03285	COG2056	Na+-H+ antiporter family
MUA21_RS03290	COG2050	protein possibly involved in aromatic compounds catabolism
MUA21_RS03305	COG1320	monovalent cation:proton antiporter activity
MUA21_RS03310	COG2212	antiporter activity
MUA21_RS03315	COG1863	multisubunit Na H antiporter MnhE subunit
MUA21_RS03320	COG0651	ATP synthesis coupled electron transport
MUA21_RS03325	COG1006	Multisubunit Na H antiporter MnhC subunit
MUA21_RS03330	COG2111	Na H antiporter
MUA21_RS03335	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MUA21_RS03335	COG2111	Na H antiporter
MUA21_RS03345	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MUA21_RS03350	COG1098	S1 RNA binding domain
MUA21_RS03355	COG1902	pentaerythritol trinitrate reductase activity
MUA21_RS03360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MUA21_RS03370	COG0584	glycerophosphoryl diester phosphodiesterase
MUA21_RS03380	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MUA21_RS03390	COG0165	Argininosuccinate lyase
MUA21_RS03395	COG0137	argininosuccinate synthase activity
MUA21_RS03400	COG0166	Belongs to the GPI family
MUA21_RS03405	COG0398	Pfam SNARE associated Golgi protein
MUA21_RS03420	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
MUA21_RS03425	COG1074	ATP-dependent DNA helicase activity
MUA21_RS03430	COG2311	Membrane
MUA21_RS03435	COG0179	Fumarylacetoacetate (FAA) hydrolase
MUA21_RS03445	COG0446	pyridine nucleotide-disulphide oxidoreductase
MUA21_RS03450	COG0561	phosphatase activity
MUA21_RS03490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MUA21_RS03510	COG0601	transmembrane transport
MUA21_RS03515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MUA21_RS03520	COG0444	Belongs to the ABC transporter superfamily
MUA21_RS03525	COG4608	Belongs to the ABC transporter superfamily
MUA21_RS03530	COG4166	transmembrane transport
MUA21_RS03535	COG0180	Tryptophanyl-tRNA synthetase
MUA21_RS03540	COG1393	Belongs to the ArsC family
MUA21_RS03545	COG4862	establishment of competence for transformation
MUA21_RS03555	COG1164	Oligoendopeptidase f
MUA21_RS03560	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MUA21_RS03565	COG2346	COG2346, Truncated hemoglobins
MUA21_RS03570	COG4116	CYTH
MUA21_RS03580	COG2357	RelA SpoT domain protein
MUA21_RS03585	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MUA21_RS03590	COG0564	pseudouridine synthase activity
MUA21_RS03595	COG2239	Acts as a magnesium transporter
MUA21_RS03600	COG0569	domain protein
MUA21_RS03600	COG0475	glutathione-regulated potassium exporter activity
MUA21_RS03610	COG0628	permease
MUA21_RS03615	COG1115	amino acid carrier protein
MUA21_RS03620	COG2382	esterase
MUA21_RS03625	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MUA21_RS03630	COG2814	Major facilitator Superfamily
MUA21_RS03635	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MUA21_RS03640	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MUA21_RS03650	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MUA21_RS03655	COG0861	Integral membrane protein TerC family
MUA21_RS03660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MUA21_RS03665	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MUA21_RS03670	COG0737	Belongs to the 5'-nucleotidase family
MUA21_RS03680	COG4873	Protein conserved in bacteria
MUA21_RS03695	COG4903	ComK protein
MUA21_RS03715	COG2314	TM2 domain
MUA21_RS03725	COG1575	Belongs to the MenA family. Type 1 subfamily
MUA21_RS03730	COG1169	isochorismate synthase
MUA21_RS03735	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MUA21_RS03740	COG2267	carboxylic ester hydrolase activity
MUA21_RS03745	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MUA21_RS03760	COG0436	Aminotransferase
MUA21_RS03765	COG3594	Acyltransferase
MUA21_RS03775	COG5632	N-Acetylmuramoyl-L-alanine amidase
MUA21_RS03775	COG4193	domain, Protein
MUA21_RS03775	COG3266	domain, Protein
MUA21_RS03775	COG5632	N-Acetylmuramoyl-L-alanine amidase
MUA21_RS03775	COG4193	domain, Protein
MUA21_RS03775	COG3266	domain, Protein
MUA21_RS03790	COG1316	TRANSCRIPTIONal
MUA21_RS03795	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MUA21_RS03810	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
MUA21_RS03815	COG1845	cytochrome c oxidase, subunit III
MUA21_RS03820	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MUA21_RS03825	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MUA21_RS03835	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MUA21_RS03840	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MUA21_RS03845	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MUA21_RS03850	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MUA21_RS03855	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MUA21_RS03860	COG0047	phosphoribosylformylglycinamidine synthase activity
MUA21_RS03865	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MUA21_RS03875	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MUA21_RS03885	COG0138	bifunctional purine biosynthesis protein purh
MUA21_RS03895	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MUA21_RS03900	COG4172	Belongs to the ABC transporter superfamily
MUA21_RS03920	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MUA21_RS03930	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MUA21_RS03945	COG1271	oxidase subunit
MUA21_RS03950	COG1294	oxidase, subunit
MUA21_RS03955	COG0569	domain protein
MUA21_RS03960	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MUA21_RS03965	COG5503	Protein of unknown function (DUF1447)
MUA21_RS03975	COG0242	peptide deformylase activity
MUA21_RS03995	COG0508	dehydrogenase complex catalyzes the overall conversion of
MUA21_RS04005	COG4476	Belongs to the UPF0223 family
MUA21_RS04015	COG3842	ATPase activity
MUA21_RS04020	COG1176	ABC-type spermidine putrescine transport system, permease component I
MUA21_RS04025	COG1177	transmembrane transport
MUA21_RS04040	COG1914	H( )-stimulated, divalent metal cation uptake system
MUA21_RS04050	COG4493	Belongs to the UPF0637 family
MUA21_RS04055	COG0483	inositol monophosphate 1-phosphatase activity
MUA21_RS04065	COG1217	gtp-binding protein TYPA
MUA21_RS04070	COG4896	Protein conserved in bacteria
MUA21_RS04080	COG4838	Belongs to the UPF0358 family
MUA21_RS04085	COG0772	Belongs to the SEDS family
MUA21_RS04095	COG1612	heme a metabolic process
MUA21_RS04100	COG0109	protoheme IX farnesyltransferase activity
MUA21_RS04110	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MUA21_RS04120	COG3679	Belongs to the UPF0342 family
MUA21_RS04130	COG4471	UPF0298 protein
MUA21_RS04140	COG0742	ribosomal rna small subunit methyltransferase
MUA21_RS04145	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MUA21_RS04155	COG1323	Belongs to the UPF0348 family
MUA21_RS04165	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MUA21_RS04175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MUA21_RS04180	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MUA21_RS04185	COG0072	phenylalanine-tRNA ligase activity
MUA21_RS04190	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MUA21_RS04195	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
MUA21_RS04205	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MUA21_RS04205	COG1796	DNA polymerase
MUA21_RS04210	COG1193	negative regulation of DNA recombination
MUA21_RS04215	COG3118	belongs to the thioredoxin family
MUA21_RS04220	COG0322	excinuclease ABC activity
MUA21_RS04225	COG2009	succinate dehydrogenase
MUA21_RS04230	COG1053	succinate dehydrogenase
MUA21_RS04235	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MUA21_RS04240	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MUA21_RS04275	COG1011	Hydrolase
MUA21_RS04280	COG0454	-acetyltransferase
MUA21_RS04285	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
MUA21_RS04290	COG2001	Belongs to the MraZ family
MUA21_RS04295	COG0275	rRNA processing
MUA21_RS04300	COG4839	cell division protein FtsL
MUA21_RS04305	COG0768	penicillin binding
MUA21_RS04310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MUA21_RS04315	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MUA21_RS04320	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MUA21_RS04325	COG0849	cell division
MUA21_RS04330	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MUA21_RS04335	COG1496	oxidoreductase activity
MUA21_RS04340	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MUA21_RS04345	COG1799	cell septum assembly
MUA21_RS04350	COG0762	integral membrane protein
MUA21_RS04360	COG3599	regulation of cell shape
MUA21_RS04365	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MUA21_RS04375	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MUA21_RS04380	COG0564	pseudouridine synthase activity
MUA21_RS04385	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MUA21_RS04390	COG2233	PERMEase
MUA21_RS04395	COG0540	Belongs to the ATCase OTCase family
MUA21_RS04405	COG0505	Belongs to the CarA family
MUA21_RS04410	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MUA21_RS04415	COG0284	orotidine-5'-phosphate decarboxylase activity
MUA21_RS04420	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MUA21_RS04430	COG2814	Major facilitator Superfamily
MUA21_RS04440	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MUA21_RS04450	COG1293	RNA-binding protein homologous to eukaryotic snRNP
MUA21_RS04455	COG0194	GDP metabolic process
MUA21_RS04460	COG1758	RNA polymerase activity
MUA21_RS04465	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MUA21_RS04470	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MUA21_RS04490	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MUA21_RS04495	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MUA21_RS04495	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MUA21_RS04500	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MUA21_RS04505	COG0631	protein serine/threonine phosphatase activity
MUA21_RS04515	COG1162	GTPase activity
MUA21_RS04520	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MUA21_RS04525	COG1564	THIamine pyrophosphokinase
MUA21_RS04530	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MUA21_RS04535	COG1302	Protein conserved in bacteria
MUA21_RS04540	COG1461	Dihydroxyacetone kinase
MUA21_RS04545	COG1760	l-serine dehydratase
MUA21_RS04550	COG1760	l-serine dehydratase
MUA21_RS04555	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MUA21_RS04565	COG1349	DNA-binding transcription factor activity
MUA21_RS04570	COG0416	fatty acid biosynthetic process
MUA21_RS04585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MUA21_RS04590	COG0571	ribonuclease III activity
MUA21_RS04595	COG1196	nuclear chromosome segregation
MUA21_RS04600	COG0552	protein localization to endoplasmic reticulum
MUA21_RS04605	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
MUA21_RS04610	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MUA21_RS04615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MUA21_RS04620	COG1028	Short-chain dehydrogenase reductase Sdr
MUA21_RS04625	COG0228	four-way junction DNA binding
MUA21_RS04630	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MUA21_RS04635	COG0336	Belongs to the RNA methyltransferase TrmD family
MUA21_RS04640	COG0335	large ribosomal subunit rRNA binding
MUA21_RS04650	COG4485	Bacterial membrane protein, YfhO
MUA21_RS04660	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MUA21_RS04665	COG0045	succinate-CoA ligase (ADP-forming) activity
MUA21_RS04675	COG0758	DNA mediated transformation
MUA21_RS04680	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MUA21_RS04685	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
MUA21_RS04690	COG4974	Belongs to the 'phage' integrase family
MUA21_RS04695	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MUA21_RS04700	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MUA21_RS04705	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
MUA21_RS04710	COG0052	Belongs to the universal ribosomal protein uS2 family
MUA21_RS04715	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MUA21_RS04720	COG0528	UMP kinase activity
MUA21_RS04725	COG0233	cytoplasmic translational termination
MUA21_RS04730	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MUA21_RS04735	COG4589	Belongs to the CDS family
MUA21_RS04745	COG0442	prolyl-tRNA aminoacylation
MUA21_RS04750	COG2176	DNA-directed DNA polymerase activity
MUA21_RS04755	COG0779	Required for maturation of 30S ribosomal subunits
MUA21_RS04760	COG0195	Participates in both transcription termination and antitermination
MUA21_RS04765	COG2740	Nucleic-acid-binding protein implicated in transcription termination
MUA21_RS04770	COG1358	cellular component organization or biogenesis
MUA21_RS04775	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MUA21_RS04790	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MUA21_RS04795	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MUA21_RS04800	COG0196	riboflavin kinase activity
MUA21_RS04805	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MUA21_RS04810	COG1185	polyribonucleotide nucleotidyltransferase activity
MUA21_RS04815	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MUA21_RS04830	COG0612	Peptidase, M16
MUA21_RS04835	COG0612	Peptidase, M16
MUA21_RS04840	COG0300	oxidoreductase activity
MUA21_RS04850	COG1426	Protein conserved in bacteria
MUA21_RS04865	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MUA21_RS04870	COG1418	mRNA catabolic process
MUA21_RS04880	COG1692	metallophosphoesterase
MUA21_RS04885	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MUA21_RS04885	COG0674	pyruvate-flavodoxin oxidoreductase activity
MUA21_RS04890	COG1013	pyruvate-flavodoxin oxidoreductase activity
MUA21_RS04905	COG1959	2 iron, 2 sulfur cluster binding
MUA21_RS04910	COG0492	ferredoxin-NADP+ reductase activity
MUA21_RS04920	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MUA21_RS04925	COG4550	Control of competence regulator ComK, YlbF/YmcA
MUA21_RS04935	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MUA21_RS04940	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MUA21_RS04950	COG1619	proteins homologs of microcin C7 resistance protein MccF
MUA21_RS04955	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MUA21_RS04960	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MUA21_RS04965	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MUA21_RS04975	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MUA21_RS04980	COG1923	regulation of RNA biosynthetic process
MUA21_RS04985	COG0386	Belongs to the glutathione peroxidase family
MUA21_RS04990	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MUA21_RS04995	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
MUA21_RS05000	COG0789	Transcriptional regulator
MUA21_RS05005	COG0174	glutamine synthetase
MUA21_RS05055	COG0527	aspartate kinase activity
MUA21_RS05060	COG0460	homoserine dehydrogenase
MUA21_RS05065	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MUA21_RS05070	COG0083	homoserine kinase activity
MUA21_RS05075	COG0561	phosphatase activity
MUA21_RS05085	COG0833	amino acid
MUA21_RS05090	COG0753	catalase activity
MUA21_RS05100	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MUA21_RS05105	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MUA21_RS05110	COG0516	GMP reductase activity
MUA21_RS05120	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MUA21_RS05140	COG3763	UPF0154 protein
MUA21_RS05145	COG0582	viral genome integration into host DNA
MUA21_RS05155	COG1396	sequence-specific DNA binding
MUA21_RS05190	COG5377	YqaJ viral recombinase family
MUA21_RS05200	COG3723	Recombinational DNA repair protein, rece pathway
MUA21_RS05215	COG1484	DNA-dependent DNA replication
MUA21_RS05290	COG1396	sequence-specific DNA binding
MUA21_RS05290	COG3800	Transcriptional regulator
MUA21_RS05335	COG3331	DNA recombination
MUA21_RS05425	COG0739	heme binding
MUA21_RS05500	COG4846	Membrane protein involved in cytochrome C biogenesis
MUA21_RS05505	COG0420	3'-5' exonuclease activity
MUA21_RS05510	COG0419	ATPase involved in DNA repair
MUA21_RS05515	COG1970	mechanosensitive ion channel activity
MUA21_RS05520	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MUA21_RS05525	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MUA21_RS05530	COG0824	Thioesterase
MUA21_RS05535	COG4841	protein insertion into membrane
MUA21_RS05540	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MUA21_RS05550	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MUA21_RS05555	COG1115	amino acid carrier protein
MUA21_RS05560	COG0628	permease
MUA21_RS05565	COG0392	lysyltransferase activity
MUA21_RS05565	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MUA21_RS05575	COG1609	Transcriptional regulator
MUA21_RS05580	COG1869	D-ribose catabolic process
MUA21_RS05585	COG1129	ABC transporter
MUA21_RS05590	COG1172	Belongs to the binding-protein-dependent transport system permease family
MUA21_RS05595	COG1879	ABC-type sugar transport system periplasmic component
MUA21_RS05620	COG1942	4-Oxalocrotonate Tautomerase
MUA21_RS05625	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MUA21_RS05635	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MUA21_RS05640	COG0287	Prephenate dehydrogenase
MUA21_RS05645	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MUA21_RS05650	COG0512	Glutamine amidotransferase of anthranilate synthase
MUA21_RS05655	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MUA21_RS05660	COG0134	indole-3-glycerol-phosphate synthase activity
MUA21_RS05670	COG0133	tryptophan synthase activity
MUA21_RS05675	COG0159	tryptophan synthase activity
MUA21_RS05685	COG2348	transferase activity, transferring amino-acyl groups
MUA21_RS05690	COG2348	transferase activity, transferring amino-acyl groups
MUA21_RS05700	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MUA21_RS05705	COG0789	Transcriptional regulator
MUA21_RS05720	COG0704	Plays a role in the regulation of phosphate uptake
MUA21_RS05725	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MUA21_RS05730	COG0581	inorganic phosphate transmembrane transporter activity
MUA21_RS05735	COG0573	inorganic phosphate transmembrane transporter activity
MUA21_RS05740	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MUA21_RS05745	COG2996	Protein conserved in bacteria
MUA21_RS05750	COG0488	(ABC) transporter
MUA21_RS05760	COG0527	aspartate kinase activity
MUA21_RS05765	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MUA21_RS05770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MUA21_RS05775	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MUA21_RS05785	COG1473	amidohydrolase
MUA21_RS05800	COG1278	Cold shock
MUA21_RS05810	COG1254	Belongs to the acylphosphatase family
MUA21_RS05820	COG3853	Toxic anion resistance protein (TelA)
MUA21_RS05825	COG1114	Component of the transport system for branched-chain amino acids
MUA21_RS05830	COG4548	von Willebrand factor, type A
MUA21_RS05835	COG0714	Associated with various cellular activities
MUA21_RS05855	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MUA21_RS05860	COG0673	inositol 2-dehydrogenase activity
MUA21_RS05865	COG0673	inositol 2-dehydrogenase activity
MUA21_RS05875	COG1082	Xylose isomerase domain protein TIM barrel
MUA21_RS05880	COG1917	Cupin 2, conserved barrel domain protein
MUA21_RS05880	COG2207	Transcriptional regulator
MUA21_RS05890	COG1396	sequence-specific DNA binding
MUA21_RS05895	COG0508	dehydrogenase complex catalyzes the overall conversion of
MUA21_RS05900	COG0567	Dehydrogenase, E1 component
MUA21_RS05905	COG5002	protein histidine kinase activity
MUA21_RS05910	COG0745	RESPONSE REGULATOR receiver
MUA21_RS05915	COG0671	phosphoesterase, PA-phosphatase related
MUA21_RS05920	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MUA21_RS05930	COG0793	Belongs to the peptidase S41A family
MUA21_RS05935	COG4479	Belongs to the UPF0346 family
MUA21_RS05945	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MUA21_RS05965	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MUA21_RS05975	COG1413	lyase activity
MUA21_RS05980	COG1413	lyase activity
MUA21_RS05990	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MUA21_RS06000	COG0328	RNA-DNA hybrid ribonuclease activity
MUA21_RS06005	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MUA21_RS06010	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MUA21_RS06020	COG2962	Rard protein
MUA21_RS06025	COG0116	Belongs to the methyltransferase superfamily
MUA21_RS06040	COG4474	Belongs to the UPF0398 family
MUA21_RS06050	COG3331	DNA recombination
MUA21_RS06055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MUA21_RS06055	COG4499	WXG100 protein secretion system (Wss), protein YukC
MUA21_RS06065	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MUA21_RS06070	COG3935	DnaD domain protein
MUA21_RS06075	COG0017	Asparaginyl-tRNA synthetase
MUA21_RS06080	COG1199	ATP-dependent helicase activity
MUA21_RS06080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MUA21_RS06090	COG0617	tRNA 3'-terminal CCA addition
MUA21_RS06095	COG0438	transferase activity, transferring glycosyl groups
MUA21_RS06100	COG1694	Mazg nucleotide pyrophosphohydrolase
MUA21_RS06105	COG2738	Putative neutral zinc metallopeptidase
MUA21_RS06110	COG4347	Protein of unknown function (DUF1405)
MUA21_RS06115	COG5582	Belongs to the UPF0302 family
MUA21_RS06125	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MUA21_RS06130	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MUA21_RS06135	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MUA21_RS06140	COG0105	UTP biosynthetic process
MUA21_RS06145	COG0142	geranyltranstransferase activity
MUA21_RS06150	COG2226	methyltransferase
MUA21_RS06165	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MUA21_RS06170	COG1160	GTP binding
MUA21_RS06175	COG0539	negative regulation of cytoplasmic translation
MUA21_RS06180	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MUA21_RS06190	COG0492	ferredoxin-NADP+ reductase activity
MUA21_RS06200	COG0514	ATP-dependent DNA helicase (RecQ)
MUA21_RS06210	COG1141	Ferredoxin
MUA21_RS06235	COG0745	RESPONSE REGULATOR receiver
MUA21_RS06240	COG1187	pseudouridine synthase activity
MUA21_RS06245	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MUA21_RS06250	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MUA21_RS06260	COG4974	Belongs to the 'phage' integrase family
MUA21_RS06265	COG0735	belongs to the Fur family
MUA21_RS06275	COG0667	Aldo Keto reductase
MUA21_RS06280	COG1028	Short-chain dehydrogenase reductase Sdr
MUA21_RS06285	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MUA21_RS06290	COG1234	tRNA 3'-trailer cleavage
MUA21_RS06295	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MUA21_RS06305	COG0366	Alpha amylase catalytic
MUA21_RS06315	COG2195	Cleaves the N-terminal amino acid of tripeptides
MUA21_RS06325	COG4129	membrane
MUA21_RS06335	COG0508	dehydrogenase complex catalyzes the overall conversion of
MUA21_RS06340	COG0022	dehydrogenase e1 component
MUA21_RS06345	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MUA21_RS06350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MUA21_RS06355	COG0280	phosphate acetyltransferase
MUA21_RS06360	COG0497	DNA recombination
MUA21_RS06365	COG1438	arginine binding
MUA21_RS06375	COG1722	exodeoxyribonuclease VII activity
MUA21_RS06380	COG1570	exodeoxyribonuclease VII activity
MUA21_RS06385	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MUA21_RS06390	COG1302	Protein conserved in bacteria
MUA21_RS06395	COG0439	Biotin carboxylase
MUA21_RS06400	COG0511	ligase activity, forming carbon-carbon bonds
MUA21_RS06405	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MUA21_RS06410	COG0006	proline dipeptidase activity
MUA21_RS06425	COG0095	Lipoate-protein ligase
MUA21_RS06430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MUA21_RS06435	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MUA21_RS06440	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MUA21_RS06445	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MUA21_RS06450	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MUA21_RS06470	COG4537	Required for transformation and DNA binding
MUA21_RS06475	COG1459	type II secretion system
MUA21_RS06480	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MUA21_RS06490	COG0011	TIGRFAM Protein of
MUA21_RS06495	COG1940	carbohydrate kinase activity
MUA21_RS06500	COG4483	Protein conserved in bacteria
MUA21_RS06505	COG0457	Tetratricopeptide repeat
MUA21_RS06505	COG0705	Rhomboid family
MUA21_RS06510	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MUA21_RS06515	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MUA21_RS06520	COG0768	penicillin binding
MUA21_RS06525	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MUA21_RS06535	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MUA21_RS06540	COG1121	(ABC) transporter
MUA21_RS06545	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MUA21_RS06550	COG0513	Belongs to the DEAD box helicase family
MUA21_RS06560	COG2384	SAM-dependent methyltransferase
MUA21_RS06565	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MUA21_RS06575	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MUA21_RS06580	COG0517	IMP dehydrogenase activity
MUA21_RS06585	COG0423	glycine-tRNA ligase activity
MUA21_RS06590	COG1381	Involved in DNA repair and RecF pathway recombination
MUA21_RS06595	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MUA21_RS06615	COG1702	phosphate starvation-inducible protein PhoH
MUA21_RS06625	COG4864	UPF0365 protein
MUA21_RS06630	COG1030	water channel activity
MUA21_RS06635	COG0828	Belongs to the bacterial ribosomal protein bS21 family
MUA21_RS06640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MUA21_RS06645	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MUA21_RS06650	COG2264	protein methyltransferase activity
MUA21_RS06655	COG0484	heat shock protein binding
MUA21_RS06660	COG0443	Heat shock 70 kDa protein
MUA21_RS06665	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MUA21_RS06670	COG1420	regulation of RNA biosynthetic process
MUA21_RS06675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MUA21_RS06680	COG0481	GTPase activity
MUA21_RS06685	COG0268	Binds directly to 16S ribosomal RNA
MUA21_RS06690	COG1466	dna polymerase III delta subunit
MUA21_RS06700	COG2131	deaminase
MUA21_RS06715	COG0799	negative regulation of ribosome biogenesis
MUA21_RS06720	COG1713	HD superfamily hydrolase involved in NAD metabolism
MUA21_RS06725	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MUA21_RS06730	COG1534	Rna-binding protein
MUA21_RS06735	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MUA21_RS06740	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MUA21_RS06745	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
MUA21_RS06750	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MUA21_RS06755	COG1914	H( )-stimulated, divalent metal cation uptake system
MUA21_RS06760	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MUA21_RS06765	COG0439	Biotin carboxylase
MUA21_RS06775	COG1984	allophanate hydrolase subunit 2
MUA21_RS06780	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MUA21_RS06785	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MUA21_RS06790	COG0572	uridine kinase
MUA21_RS06795	COG0826	peptidase U32
MUA21_RS06800	COG0826	peptidase U32
MUA21_RS06805	COG4122	O-methyltransferase activity
MUA21_RS06810	COG3906	Belongs to the UPF0473 family
MUA21_RS06815	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MUA21_RS06820	COG4472	Bacterial protein of unknown function (DUF965)
MUA21_RS06825	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MUA21_RS06830	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MUA21_RS06840	COG0482	sulfurtransferase activity
MUA21_RS06845	COG1104	cysteine desulfurase activity
MUA21_RS06850	COG0488	(ABC) transporter
MUA21_RS06855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MUA21_RS06870	COG1959	2 iron, 2 sulfur cluster binding
MUA21_RS06875	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MUA21_RS06880	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MUA21_RS06890	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MUA21_RS06895	COG0124	histidyl-tRNA synthetase
MUA21_RS06900	COG0860	N-Acetylmuramoyl-L-alanine amidase
MUA21_RS06905	COG1490	D-aminoacyl-tRNA deacylase activity
MUA21_RS06910	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MUA21_RS06915	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MUA21_RS06920	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MUA21_RS06920	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MUA21_RS06935	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MUA21_RS06935	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MUA21_RS06940	COG1862	Preprotein translocase
MUA21_RS06945	COG0343	queuine tRNA-ribosyltransferase activity
MUA21_RS06950	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MUA21_RS06955	COG2255	four-way junction helicase activity
MUA21_RS06960	COG0632	four-way junction helicase activity
MUA21_RS06965	COG4492	Belongs to the UPF0735 family
MUA21_RS06970	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MUA21_RS06980	COG2868	ribosomal protein
MUA21_RS06985	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MUA21_RS07015	COG2003	Belongs to the UPF0758 family
MUA21_RS07030	COG0656	L-ascorbic acid biosynthetic process
MUA21_RS07035	COG0285	dihydrofolate synthase activity
MUA21_RS07040	COG0525	valine-tRNA ligase activity
MUA21_RS07045	COG2818	Glycosylase
MUA21_RS07055	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MUA21_RS07060	COG0113	porphobilinogen synthase activity
MUA21_RS07070	COG0181	hydroxymethylbilane synthase activity
MUA21_RS07075	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MUA21_RS07080	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MUA21_RS07085	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MUA21_RS07100	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MUA21_RS07105	COG0544	peptidyl-prolyl cis-trans isomerase activity
MUA21_RS07115	COG4112	unkown
MUA21_RS07120	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MUA21_RS07125	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MUA21_RS07130	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MUA21_RS07135	COG0833	amino acid
MUA21_RS07140	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MUA21_RS07145	COG1484	DNA-dependent DNA replication
MUA21_RS07155	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MUA21_RS07160	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MUA21_RS07165	COG0237	dephospho-CoA kinase activity
MUA21_RS07175	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MUA21_RS07175	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MUA21_RS07180	COG5002	protein histidine kinase activity
MUA21_RS07185	COG0745	RESPONSE REGULATOR receiver
MUA21_RS07190	COG0538	isocitrate dehydrogenase activity
MUA21_RS07195	COG0372	Belongs to the citrate synthase family
MUA21_RS07200	COG1113	amino acid transport
MUA21_RS07205	COG0469	pyruvate kinase activity
MUA21_RS07210	COG0205	6-phosphofructokinase activity
MUA21_RS07215	COG0825	malonyl-CoA metabolic process
MUA21_RS07220	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MUA21_RS07225	COG0281	malic enzyme
MUA21_RS07230	COG0587	DNA-directed DNA polymerase activity
MUA21_RS07235	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MUA21_RS07240	COG4109	DRTGG domain
MUA21_RS07250	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MUA21_RS07255	COG0006	proline dipeptidase activity
MUA21_RS07260	COG3142	Participates in the control of copper homeostasis
MUA21_RS07280	COG0686	Belongs to the AlaDH PNT family
MUA21_RS07285	COG0589	response to stress
MUA21_RS07295	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MUA21_RS07300	COG0827	DNA restriction-modification system
MUA21_RS07305	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
MUA21_RS07310	COG1714	RDD family
MUA21_RS07315	COG0616	signal peptide processing
MUA21_RS07320	COG0730	response to heat
MUA21_RS07325	COG0301	tRNA thio-modification
MUA21_RS07330	COG1104	cysteine desulfurase activity
MUA21_RS07335	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
MUA21_RS07340	COG1956	GAF domain-containing protein
MUA21_RS07345	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MUA21_RS07355	COG0584	glycerophosphoryl diester phosphodiesterase
MUA21_RS07360	COG1764	response to oxidative stress
MUA21_RS07370	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MUA21_RS07380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MUA21_RS07380	COG1263	PTS System
MUA21_RS07385	COG0204	Acyl-transferase
MUA21_RS07390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MUA21_RS07395	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MUA21_RS07400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MUA21_RS07410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MUA21_RS07415	COG0454	-acetyltransferase
MUA21_RS07420	COG0123	including yeast histone deacetylase and acetoin utilization protein
MUA21_RS07425	COG1609	Transcriptional regulator
MUA21_RS07430	COG1605	Chorismate mutase
MUA21_RS07430	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MUA21_RS07440	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
MUA21_RS07445	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MUA21_RS07450	COG1674	ftsk spoiiie
MUA21_RS07455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MUA21_RS07460	COG4848	Belongs to the UPF0354 family
MUA21_RS07465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MUA21_RS07470	COG1363	Peptidase, m42
MUA21_RS07475	COG5584	Small secreted protein
MUA21_RS07480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MUA21_RS07490	COG2801	Transposase and inactivated derivatives
MUA21_RS07495	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MUA21_RS07500	COG0510	thiamine kinase activity
MUA21_RS07505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MUA21_RS07510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MUA21_RS07520	COG1187	pseudouridine synthase activity
MUA21_RS07525	COG2244	polysaccharide biosynthetic process
MUA21_RS07530	COG2081	HI0933 family
MUA21_RS07545	COG0495	leucyl-tRNA aminoacylation
MUA21_RS07550	COG2814	Major facilitator Superfamily
MUA21_RS07555	COG1242	4 iron, 4 sulfur cluster binding
MUA21_RS07560	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MUA21_RS07570	COG0039	L-malate dehydrogenase activity
MUA21_RS07575	COG2267	carboxylic ester hydrolase activity
MUA21_RS07585	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MUA21_RS07590	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MUA21_RS07590	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MUA21_RS07595	COG0307	riboflavin synthase, alpha
MUA21_RS07600	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MUA21_RS07600	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MUA21_RS07615	COG3266	domain, Protein
MUA21_RS07615	COG4193	domain, Protein
MUA21_RS07615	COG5632	N-Acetylmuramoyl-L-alanine amidase
MUA21_RS07640	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MUA21_RS07650	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MUA21_RS07655	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MUA21_RS07660	COG0656	L-ascorbic acid biosynthetic process
MUA21_RS07670	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MUA21_RS07675	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MUA21_RS07680	COG1506	peptidase
MUA21_RS07690	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MUA21_RS07755	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MUA21_RS07760	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MUA21_RS07765	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MUA21_RS07775	COG4473	ABC transporter
MUA21_RS07780	COG1131	(ABC) transporter
MUA21_RS07785	COG0537	adenosine 5'-monophosphoramidase activity
MUA21_RS07800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MUA21_RS07810	COG4717	serine-type aminopeptidase activity
MUA21_RS07815	COG0420	3'-5' exonuclease activity
MUA21_RS07820	COG3679	Belongs to the UPF0342 family
MUA21_RS07825	COG4399	Belongs to the UPF0754 family
MUA21_RS07835	COG0788	formyltetrahydrofolate deformylase activity
MUA21_RS07855	COG1301	dicarboxylic acid transport
MUA21_RS07860	COG2197	response regulator
MUA21_RS07865	COG2203	Gaf domain
MUA21_RS07865	COG4585	Histidine kinase
MUA21_RS07870	COG0564	pseudouridine synthase activity
MUA21_RS07875	COG0114	fumarate hydratase activity
MUA21_RS07890	COG0363	glucosamine-6-phosphate deaminase activity
MUA21_RS07900	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MUA21_RS07905	COG1126	abc transporter atp-binding protein
MUA21_RS07910	COG0765	amino acid transport
MUA21_RS08075	COG0735	belongs to the Fur family
MUA21_RS08080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MUA21_RS08085	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MUA21_RS08090	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MUA21_RS08095	COG4129	membrane
MUA21_RS08105	COG3557	Belongs to the UPF0374 family
MUA21_RS08110	COG1194	a g-specific adenine glycosylase
MUA21_RS08115	COG1988	membrane-bound metal-dependent
MUA21_RS08125	COG1134	teichoic acid transport
MUA21_RS08135	COG2137	regulation of response to DNA damage stimulus
MUA21_RS08140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MUA21_RS08145	COG0693	protein deglycase activity
MUA21_RS08160	COG1607	acyl-coa hydrolase
MUA21_RS08165	COG2309	aminopeptidase activity
MUA21_RS08170	COG4840	Belongs to the UPF0435 family
MUA21_RS08175	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MUA21_RS08185	COG1295	ribonuclease BN
MUA21_RS08190	COG2197	response regulator
MUA21_RS08195	COG4585	Histidine kinase
MUA21_RS08210	COG0024	Methionine aminopeptidase
MUA21_RS08215	COG4129	membrane
MUA21_RS08230	COG1528	Iron-storage protein
MUA21_RS08240	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MUA21_RS08250	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MUA21_RS08255	COG1597	lipid kinase activity
MUA21_RS08260	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MUA21_RS08265	COG0154	amidase activity
MUA21_RS08270	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MUA21_RS08275	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MUA21_RS08280	COG4851	CamS sex pheromone cAM373 precursor
MUA21_RS08285	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MUA21_RS08290	COG0210	DNA helicase
MUA21_RS08300	COG4496	protein, YerC YecD
MUA21_RS08305	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MUA21_RS08315	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
MUA21_RS08320	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MUA21_RS08325	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MUA21_RS08335	COG0077	Prephenate dehydratase
MUA21_RS08340	COG0471	metal ion transport
MUA21_RS08350	COG1335	isochorismatase
MUA21_RS08355	COG1227	inorganic diphosphatase activity
MUA21_RS08360	COG1012	belongs to the aldehyde dehydrogenase family
MUA21_RS08365	COG2706	6-phosphogluconolactonase activity
MUA21_RS08410	COG1131	(ABC) transporter
MUA21_RS08425	COG1725	Transcriptional regulator
MUA21_RS08450	COG0459	protein refolding
MUA21_RS08455	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MUA21_RS08475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MUA21_RS08480	COG4512	PFAM Accessory gene regulator B
MUA21_RS08490	COG3290	protein histidine kinase activity
MUA21_RS08495	COG3279	Response regulator of the LytR AlgR family
MUA21_RS08500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MUA21_RS08505	COG1621	beta-fructofuranosidase activity
MUA21_RS08510	COG0425	Belongs to the sulfur carrier protein TusA family
MUA21_RS08520	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
MUA21_RS08525	COG0488	(ABC) transporter
MUA21_RS08530	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MUA21_RS08540	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MUA21_RS08545	COG0456	acetyltransferase
MUA21_RS08550	COG1214	PFAM Peptidase M22, glycoprotease
MUA21_RS08555	COG0802	atpase or kinase
MUA21_RS08560	COG0129	dihydroxy-acid dehydratase activity
MUA21_RS08565	COG0028	Belongs to the TPP enzyme family
MUA21_RS08570	COG0440	acetolactate synthase activity
MUA21_RS08575	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MUA21_RS08580	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MUA21_RS08585	COG0473	3-isopropylmalate dehydrogenase activity
MUA21_RS08590	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MUA21_RS08595	COG0066	3-isopropylmalate dehydratase activity
MUA21_RS08600	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MUA21_RS08630	COG3091	SprT-like family
MUA21_RS08635	COG2183	response to ionizing radiation
MUA21_RS08640	COG1191	sigma factor activity
MUA21_RS08655	COG2208	phosphoserine phosphatase activity
MUA21_RS08660	COG2337	Toxic component of a toxin-antitoxin (TA) module
MUA21_RS08670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MUA21_RS08680	COG3402	PFAM membrane-flanked domain
MUA21_RS08685	COG3428	Bacterial PH domain
MUA21_RS08695	COG0513	Belongs to the DEAD box helicase family
MUA21_RS08700	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MUA21_RS08705	COG1181	Belongs to the D-alanine--D-alanine ligase family
MUA21_RS08710	COG0772	Belongs to the SEDS family
MUA21_RS08725	COG1937	Protein conserved in bacteria
MUA21_RS08735	COG1418	mRNA catabolic process
MUA21_RS08740	COG0706	membrane insertase activity
MUA21_RS08745	COG0352	thiamine-phosphate diphosphorylase activity
MUA21_RS08750	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
MUA21_RS08760	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MUA21_RS08765	COG1388	LysM domain
MUA21_RS08770	COG0629	single-stranded DNA binding
MUA21_RS08780	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MUA21_RS08785	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MUA21_RS08795	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MUA21_RS08800	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MUA21_RS08805	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MUA21_RS08810	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MUA21_RS08815	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MUA21_RS08820	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MUA21_RS08825	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MUA21_RS08830	COG0356	it plays a direct role in the translocation of protons across the membrane
MUA21_RS08840	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MUA21_RS08845	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MUA21_RS08850	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MUA21_RS08855	COG4475	Protein of unknown function (DUF436)
MUA21_RS08860	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MUA21_RS08865	COG0009	L-threonylcarbamoyladenylate synthase
MUA21_RS08870	COG2890	protein-(glutamine-N5) methyltransferase activity
MUA21_RS08875	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MUA21_RS08880	COG1435	thymidine kinase activity
MUA21_RS08885	COG0254	rRNA binding
MUA21_RS08890	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MUA21_RS08895	COG1012	belongs to the aldehyde dehydrogenase family
MUA21_RS08905	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MUA21_RS08910	COG0191	fructose-bisphosphate aldolase activity
MUA21_RS08920	COG0504	CTP synthase activity
MUA21_RS08925	COG3343	RNA polymerase activity
MUA21_RS08930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MUA21_RS08940	COG5146	pantothenate kinase activity
MUA21_RS08960	COG1854	S-ribosylhomocysteine lyase activity
MUA21_RS08970	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
MUA21_RS08975	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
MUA21_RS08980	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MUA21_RS08990	COG0783	Belongs to the Dps family
MUA21_RS08995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MUA21_RS09010	COG2855	membrane
MUA21_RS09020	COG1482	cell wall glycoprotein biosynthetic process
MUA21_RS09025	COG2186	Transcriptional regulator
MUA21_RS09030	COG0702	epimerase
MUA21_RS09035	COG0640	Transcriptional regulator
MUA21_RS09055	COG0561	phosphatase activity
MUA21_RS09060	COG1119	ATPase activity
MUA21_RS09075	COG2213	PTS system mannitol-specific
MUA21_RS09080	COG3711	transcriptional antiterminator
MUA21_RS09090	COG0246	Mannitol dehydrogenase
MUA21_RS09095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MUA21_RS09105	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MUA21_RS09160	COG0489	protein tyrosine kinase activity
MUA21_RS09165	COG2814	Major facilitator Superfamily
MUA21_RS09180	COG1272	protein, Hemolysin III
MUA21_RS09185	COG4284	Utp--glucose-1-phosphate uridylyltransferase
MUA21_RS09190	COG1988	membrane-bound metal-dependent
MUA21_RS09200	COG2329	Antibiotic biosynthesis monooxygenase
MUA21_RS09205	COG3314	Sporulation integral membrane protein YlbJ
MUA21_RS09210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MUA21_RS09215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MUA21_RS09220	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
MUA21_RS09225	COG3457	Alanine racemase
MUA21_RS09230	COG4264	IucA IucC family
MUA21_RS09235	COG2814	Major facilitator Superfamily
MUA21_RS09240	COG4264	IucA IucC family
MUA21_RS09245	COG1302	Protein conserved in bacteria
MUA21_RS09260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MUA21_RS09265	COG0604	alcohol dehydrogenase
MUA21_RS09270	COG2130	NADP-dependent
MUA21_RS09275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MUA21_RS09285	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MUA21_RS09290	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MUA21_RS09295	COG0101	tRNA pseudouridine synthase activity
MUA21_RS09305	COG1122	ATPase activity
MUA21_RS09310	COG1122	ATPase activity
MUA21_RS09315	COG0203	ribosomal protein L17
MUA21_RS09320	COG0202	RNA polymerase activity
MUA21_RS09325	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MUA21_RS09330	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MUA21_RS09335	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MUA21_RS09345	COG0563	adenylate kinase activity
MUA21_RS09350	COG0201	protein transport
MUA21_RS09360	COG1841	ribosomal large subunit assembly
MUA21_RS09365	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MUA21_RS09370	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MUA21_RS09375	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MUA21_RS09380	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MUA21_RS09385	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MUA21_RS09390	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MUA21_RS09395	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MUA21_RS09400	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MUA21_RS09405	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MUA21_RS09410	COG0255	Belongs to the universal ribosomal protein uL29 family
MUA21_RS09415	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MUA21_RS09420	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MUA21_RS09425	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
MUA21_RS09430	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MUA21_RS09435	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MUA21_RS09440	COG0089	rRNA binding
MUA21_RS09445	COG0088	Forms part of the polypeptide exit tunnel
MUA21_RS09450	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MUA21_RS09455	COG0051	transcription antitermination factor activity, RNA binding
MUA21_RS09465	COG2252	PERMEase
MUA21_RS09470	COG0551	DNA topoisomerase type I activity
MUA21_RS09470	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MUA21_RS09480	COG4975	Glucose uptake
MUA21_RS09485	COG1028	Short-chain dehydrogenase reductase Sdr
MUA21_RS09505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MUA21_RS09510	COG2348	transferase activity, transferring amino-acyl groups
MUA21_RS09530	COG2814	Major facilitator Superfamily
MUA21_RS09540	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MUA21_RS09545	COG0746	molybdenum cofactor guanylyltransferase activity
MUA21_RS09560	COG1763	Mo-molybdopterin cofactor biosynthetic process
MUA21_RS09570	COG0315	cyclic pyranopterin monophosphate synthase activity
MUA21_RS09575	COG0521	Mo-molybdopterin cofactor biosynthetic process
MUA21_RS09580	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MUA21_RS09595	COG4149	molybdate abc transporter
MUA21_RS09600	COG0725	ABC transporter, periplasmic molybdate-binding protein
MUA21_RS09605	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
MUA21_RS09610	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MUA21_RS09615	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MUA21_RS09620	COG1609	Transcriptional regulator
MUA21_RS09625	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MUA21_RS09635	COG1268	BioY protein
MUA21_RS09640	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MUA21_RS09645	COG1960	acyl-CoA dehydrogenase activity
MUA21_RS09650	COG1126	abc transporter atp-binding protein
MUA21_RS09660	COG0765	amino acid transport
MUA21_RS09665	COG0765	amino acid transport
MUA21_RS09690	COG3942	CHAP domain
MUA21_RS09700	COG1757	Na H antiporter
MUA21_RS09720	COG2076	Multidrug Resistance protein
MUA21_RS09725	COG2076	Multidrug Resistance protein
MUA21_RS09730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MUA21_RS09740	COG4193	domain, Protein
MUA21_RS09755	COG3383	formate dehydrogenase (NAD+) activity
MUA21_RS09760	COG1316	TRANSCRIPTIONal
MUA21_RS09790	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
MUA21_RS09795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MUA21_RS09795	COG1263	PTS System
MUA21_RS09800	COG1737	Transcriptional regulator
MUA21_RS09805	COG1785	Belongs to the alkaline phosphatase family
MUA21_RS09810	COG1113	amino acid transport
MUA21_RS09835	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MUA21_RS09840	COG0385	Bile acid
MUA21_RS09850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MUA21_RS09850	COG1263	PTS System
MUA21_RS09855	COG1737	Transcriptional regulator
MUA21_RS09870	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MUA21_RS09875	COG1028	Short-chain dehydrogenase reductase Sdr
MUA21_RS09880	COG1473	amidohydrolase
MUA21_RS09885	COG0659	secondary active sulfate transmembrane transporter activity
MUA21_RS09890	COG1228	amidohydrolase
MUA21_RS09895	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MUA21_RS09900	COG3314	Sporulation integral membrane protein YlbJ
MUA21_RS09905	COG0583	DNA-binding transcription factor activity
MUA21_RS09910	COG0010	Belongs to the arginase family
MUA21_RS09915	COG1266	CAAX protease self-immunity
MUA21_RS09920	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MUA21_RS09925	COG2258	MOSC domain
MUA21_RS09930	COG2017	converts alpha-aldose to the beta-anomer
MUA21_RS09935	COG1668	transmembrane transport
MUA21_RS09940	COG4152	abc transporter atp-binding protein
MUA21_RS09950	COG2094	Belongs to the DNA glycosylase MPG family
MUA21_RS09955	COG1757	Na H antiporter
MUA21_RS09970	COG1695	Transcriptional regulator
MUA21_RS09975	COG0786	glutamate:sodium symporter activity
MUA21_RS09985	COG1304	FMN binding
MUA21_RS10015	COG2814	Major facilitator Superfamily
MUA21_RS10020	COG1566	PFAM secretion protein HlyD family protein
MUA21_RS10030	COG2814	Major facilitator Superfamily
MUA21_RS10035	COG4640	response to antibiotic
MUA21_RS10050	COG1136	(ABC) transporter
MUA21_RS10055	COG0577	efflux transmembrane transporter activity
MUA21_RS10060	COG0745	RESPONSE REGULATOR receiver
MUA21_RS10065	COG3850	Histidine kinase
MUA21_RS10065	COG5002	protein histidine kinase activity
MUA21_RS10075	COG0438	transferase activity, transferring glycosyl groups
MUA21_RS10080	COG1620	l-lactate permease
MUA21_RS10085	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MUA21_RS10100	COG0604	alcohol dehydrogenase
MUA21_RS10105	COG2814	Major facilitator Superfamily
MUA21_RS10115	COG0492	ferredoxin-NADP+ reductase activity
MUA21_RS10155	COG1349	DNA-binding transcription factor activity
MUA21_RS10160	COG1288	antiporter activity
MUA21_RS10165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MUA21_RS10170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MUA21_RS10175	COG1283	sodium-dependent phosphate transmembrane transporter activity
MUA21_RS10210	COG1846	Transcriptional regulator
MUA21_RS10235	COG4585	Histidine kinase
MUA21_RS10245	COG2181	nitrate reductase activity
MUA21_RS10255	COG1140	nitrate reductase beta subunit
MUA21_RS10260	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MUA21_RS10280	COG2146	nitrite reductase [NAD(P)H] activity
MUA21_RS10285	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MUA21_RS10290	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MUA21_RS10290	COG1648	precorrin-2 dehydrogenase activity
MUA21_RS10300	COG0454	-acetyltransferase
MUA21_RS10330	COG0803	Belongs to the bacterial solute-binding protein 9 family
MUA21_RS10330	COG3443	Belongs to the bacterial solute-binding protein 9 family
MUA21_RS10350	COG2814	Major facilitator Superfamily
MUA21_RS10360	COG0588	phosphoglycerate mutase activity
MUA21_RS10365	COG1388	LysM domain
MUA21_RS10370	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MUA21_RS10380	COG2814	Major facilitator Superfamily
MUA21_RS10395	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MUA21_RS10400	COG0706	membrane insertase activity
MUA21_RS10410	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
MUA21_RS10430	COG4187	Peptidase family M20/M25/M40
MUA21_RS10440	COG3275	phosphorelay sensor kinase activity
MUA21_RS10445	COG3279	Response regulator of the LytR AlgR family
MUA21_RS10450	COG1380	Effector of murein hydrolase LrgA
MUA21_RS10455	COG1346	cytolysis
MUA21_RS10465	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MUA21_RS10465	COG1116	anion transmembrane transporter activity
MUA21_RS10475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MUA21_RS10490	COG1174	glycine betaine transport
MUA21_RS10500	COG1174	glycine betaine transport
MUA21_RS10515	COG1250	3-hydroxyacyl-CoA dehydrogenase
MUA21_RS10520	COG3246	L-lysine catabolic process to acetate
MUA21_RS10530	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
MUA21_RS10535	COG2851	Citrate transporter
MUA21_RS10540	COG2814	Major facilitator Superfamily
MUA21_RS10545	COG0390	transport system, permease component
MUA21_RS10550	COG4619	ABC transporter
MUA21_RS10560	COG0069	glutamate synthase activity
MUA21_RS10570	COG1363	Peptidase, m42
MUA21_RS10575	COG1028	Short-chain dehydrogenase reductase Sdr
MUA21_RS10580	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
MUA21_RS10585	COG0248	Ppx GppA phosphatase
MUA21_RS10590	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MUA21_RS10600	COG3048	D-serine ammonia-lyase activity
MUA21_RS10610	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MUA21_RS10615	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MUA21_RS10620	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MUA21_RS10625	COG0131	Imidazoleglycerol-phosphate dehydratase
MUA21_RS10630	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MUA21_RS10635	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MUA21_RS10640	COG0107	imidazoleglycerol-phosphate synthase activity
MUA21_RS10655	COG4221	oxidoreductase activity
MUA21_RS10685	COG3250	beta-galactosidase activity
MUA21_RS10690	COG2211	Major facilitator Superfamily
MUA21_RS10695	COG2207	Transcriptional regulator
MUA21_RS10700	COG3949	Membrane
MUA21_RS10705	COG2610	gluconate transmembrane transporter activity
MUA21_RS10710	COG1070	Carbohydrate kinase
MUA21_RS10715	COG1802	Transcriptional regulator
MUA21_RS10725	COG2357	RelA SpoT domain protein
MUA21_RS10730	COG4876	unkown
MUA21_RS10750	COG3527	Alpha-acetolactate decarboxylase
MUA21_RS10760	COG2271	Major facilitator Superfamily
MUA21_RS10765	COG0586	Pfam SNARE associated Golgi protein
MUA21_RS10770	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MUA21_RS10775	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
MUA21_RS10780	COG3949	Membrane
MUA21_RS10785	COG0400	carboxylic ester hydrolase activity
MUA21_RS10790	COG0346	lactoylglutathione lyase activity
MUA21_RS10795	COG0346	lactoylglutathione lyase activity
MUA21_RS10800	COG1846	Transcriptional regulator
MUA21_RS10805	COG1012	belongs to the aldehyde dehydrogenase family
MUA21_RS10810	COG0803	Belongs to the bacterial solute-binding protein 9 family
MUA21_RS10820	COG1132	(ABC) transporter
MUA21_RS10825	COG1132	(ABC) transporter
MUA21_RS10830	COG2514	catechol 2,3-dioxygenase activity
MUA21_RS10835	COG0778	Nitroreductase
MUA21_RS10840	COG0561	phosphatase activity
MUA21_RS10845	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MUA21_RS10860	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MUA21_RS10865	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
MUA21_RS10870	COG3764	Sortase (surface protein transpeptidase)
MUA21_RS10890	COG1063	alcohol dehydrogenase
MUA21_RS10895	COG1070	Carbohydrate kinase
MUA21_RS10905	COG1609	Transcriptional regulator
MUA21_RS10915	COG1129	ABC transporter
MUA21_RS10935	COG3949	Membrane
MUA21_RS10960	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MUA21_RS10975	COG0657	acetylesterase activity
MUA21_RS10990	COG2515	1-aminocyclopropane-1-carboxylate deaminase
MUA21_RS11005	COG1288	antiporter activity
MUA21_RS11010	COG0028	Belongs to the TPP enzyme family
MUA21_RS11020	COG1380	Effector of murein hydrolase LrgA
MUA21_RS11025	COG0583	DNA-binding transcription factor activity
MUA21_RS11030	COG1757	Na H antiporter
MUA21_RS11035	COG3386	PFAM SMP-30 Gluconolaconase
MUA21_RS11050	COG3425	synthase
MUA21_RS11055	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MUA21_RS11060	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MUA21_RS11080	COG1473	amidohydrolase
MUA21_RS11095	COG2409	Drug exporters of the RND superfamily
MUA21_RS11105	COG1012	belongs to the aldehyde dehydrogenase family
MUA21_RS11120	COG4336	lyase activity
MUA21_RS11135	COG5505	Protein of unknown function (DUF819)
MUA21_RS11140	COG0471	metal ion transport
MUA21_RS11150	COG1028	Short-chain dehydrogenase reductase Sdr
MUA21_RS11155	COG0577	efflux transmembrane transporter activity
MUA21_RS11160	COG1136	(ABC) transporter
MUA21_RS11165	COG0659	secondary active sulfate transmembrane transporter activity
MUA21_RS11170	COG2217	Heavy metal translocating P-type atpase
MUA21_RS11175	COG2608	mercury ion transmembrane transporter activity
MUA21_RS11185	COG0436	Aminotransferase
MUA21_RS11190	COG0741	lytic transglycosylase activity
MUA21_RS11205	COG3189	MarR family transcriptional regulator
MUA21_RS11225	COG0697	spore germination
MUA21_RS11240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MUA21_RS11250	COG3001	Fructosamine kinase
MUA21_RS11255	COG0167	dihydroorotate dehydrogenase activity
MUA21_RS11265	COG0561	phosphatase activity
MUA21_RS11280	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MUA21_RS11305	COG0747	negative chemotaxis
MUA21_RS11310	COG4413	Urea transporter
MUA21_RS11315	COG0831	urea catabolic process
MUA21_RS11320	COG0832	Belongs to the urease beta subunit family
MUA21_RS11325	COG0804	urea catabolic process
MUA21_RS11330	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
MUA21_RS11335	COG0830	nickel cation binding
MUA21_RS11340	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
MUA21_RS11345	COG0829	nickel cation binding
MUA21_RS11355	COG3949	Membrane
MUA21_RS11365	COG1309	transcriptional regulator
MUA21_RS11380	COG1309	transcriptional regulator
MUA21_RS11410	COG1482	cell wall glycoprotein biosynthetic process
MUA21_RS11415	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MUA21_RS11415	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MUA21_RS11415	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MUA21_RS11420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MUA21_RS11420	COG3711	transcriptional antiterminator
MUA21_RS11425	COG0039	L-malate dehydrogenase activity
MUA21_RS11430	COG1464	Belongs to the NlpA lipoprotein family
MUA21_RS11445	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MUA21_RS11460	COG3037	sugar-specific permease SgaT UlaA
MUA21_RS11470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MUA21_RS11475	COG3711	transcriptional antiterminator
MUA21_RS11515	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MUA21_RS11525	COG0363	glucosamine-6-phosphate deaminase activity
MUA21_RS11530	COG2190	(PTS) system
MUA21_RS11530	COG1263	PTS System
MUA21_RS11530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MUA21_RS11540	COG2814	Major facilitator Superfamily
MUA21_RS11545	COG1620	l-lactate permease
MUA21_RS11550	COG1063	alcohol dehydrogenase
MUA21_RS11560	COG1414	Transcriptional regulator
MUA21_RS11570	COG0431	NADPH-dependent FMN reductase
MUA21_RS11575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MUA21_RS11580	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MUA21_RS11585	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MUA21_RS11590	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MUA21_RS11595	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MUA21_RS11600	COG2610	gluconate transmembrane transporter activity
MUA21_RS11625	COG0477	Major facilitator Superfamily
MUA21_RS11630	COG1957	nucleoside hydrolase
MUA21_RS11635	COG2843	Capsule synthesis protein
MUA21_RS11640	COG0778	Nitroreductase
MUA21_RS11650	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
MUA21_RS11655	COG1012	belongs to the aldehyde dehydrogenase family
MUA21_RS11660	COG1510	regulation of RNA biosynthetic process
MUA21_RS11665	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MUA21_RS11695	COG0531	amino acid
MUA21_RS11700	COG1012	belongs to the aldehyde dehydrogenase family
MUA21_RS11705	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MUA21_RS11710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MUA21_RS11720	COG2807	transmembrane transport
MUA21_RS11725	COG1476	TRANSCRIPTIONal
MUA21_RS11750	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MUA21_RS11755	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MUA21_RS11755	COG0574	Belongs to the PEP-utilizing enzyme family
MUA21_RS11760	COG3835	regulator
MUA21_RS11775	COG3875	lactate racemase activity
MUA21_RS11780	COG1606	tRNA processing
MUA21_RS11785	COG1691	(AIR) carboxylase
MUA21_RS11790	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
MUA21_RS11800	COG0673	inositol 2-dehydrogenase activity
MUA21_RS11825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MUA21_RS11840	COG3961	Belongs to the TPP enzyme family
MUA21_RS11845	COG1846	Transcriptional regulator
MUA21_RS11850	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MUA21_RS11865	COG0584	glycerophosphoryl diester phosphodiesterase
MUA21_RS11890	COG2814	Major facilitator Superfamily
MUA21_RS11895	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MUA21_RS11900	COG0477	Major facilitator Superfamily
MUA21_RS11925	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MUA21_RS11935	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MUA21_RS11935	COG3583	domain protein
MUA21_RS11935	COG4932	domain protein
MUA21_RS11950	COG0346	lactoylglutathione lyase activity
MUA21_RS11955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MUA21_RS11960	COG0431	NADPH-dependent FMN reductase
MUA21_RS11970	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MUA21_RS11970	COG3583	domain protein
MUA21_RS11970	COG4932	domain protein
MUA21_RS11975	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
MUA21_RS11990	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MUA21_RS11995	COG2022	thiamine diphosphate biosynthetic process
MUA21_RS12010	COG1070	Carbohydrate kinase
MUA21_RS12025	COG2207	Transcriptional regulator
MUA21_RS12025	COG1917	Cupin 2, conserved barrel domain protein
MUA21_RS12040	COG1511	domain protein
MUA21_RS12040	COG1511	domain protein
MUA21_RS12055	COG1054	Belongs to the UPF0176 family
MUA21_RS12065	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MUA21_RS12070	COG1388	LysM domain
MUA21_RS12095	COG0733	neurotransmitter:sodium symporter activity
MUA21_RS12100	COG1114	Component of the transport system for branched-chain amino acids
MUA21_RS12105	COG5646	InterPro IPR014922
MUA21_RS12110	COG1647	Serine aminopeptidase, S33
MUA21_RS12115	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MUA21_RS12120	COG2807	transmembrane transport
MUA21_RS12135	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MUA21_RS12140	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MUA21_RS12145	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
MUA21_RS12150	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
MUA21_RS12155	COG3257	ureidoglycine aminohydrolase activity
MUA21_RS12160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MUA21_RS12170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MUA21_RS12175	COG0406	alpha-ribazole phosphatase activity
MUA21_RS12180	COG1115	amino acid carrier protein
MUA21_RS12185	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MUA21_RS12190	COG1953	Uracil, thiamine, allantoin
MUA21_RS12195	COG2508	Transcriptional regulator
MUA21_RS12200	COG2814	Major facilitator Superfamily
MUA21_RS12235	COG0456	acetyltransferase
MUA21_RS12235	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MUA21_RS12260	COG1764	response to oxidative stress
MUA21_RS12300	COG3728	DNA packaging
MUA21_RS12300	COG5484	DNA packaging
MUA21_RS12380	COG0582	viral genome integration into host DNA
MUA21_RS12385	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MUA21_RS12385	COG0519	Catalyzes the synthesis of GMP from XMP
MUA21_RS12390	COG0516	GMP reductase activity
MUA21_RS12390	COG0517	IMP dehydrogenase activity
MUA21_RS12395	COG2233	PERMEase
MUA21_RS12400	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MUA21_RS12420	COG1823	symporter activity
MUA21_RS12435	COG1760	l-serine dehydratase
MUA21_RS12450	COG0778	Nitroreductase
MUA21_RS12455	COG0753	catalase activity
MUA21_RS12460	COG3620	sequence-specific DNA binding
MUA21_RS12465	COG3279	Response regulator of the LytR AlgR family
MUA21_RS12480	COG0450	alkyl hydroperoxide reductase
MUA21_RS12485	COG3634	alkyl hydroperoxide reductase activity
MUA21_RS12520	COG1280	lysine exporter protein (LysE YggA)
MUA21_RS12525	COG2076	Multidrug Resistance protein
MUA21_RS12530	COG2076	Multidrug Resistance protein
MUA21_RS12550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MUA21_RS12565	COG4195	phage-related replication protein
MUA21_RS12570	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MUA21_RS12585	COG5632	N-Acetylmuramoyl-L-alanine amidase
MUA21_RS12585	COG3266	domain, Protein
MUA21_RS12585	COG4193	domain, Protein
MUA21_RS12600	COG1476	TRANSCRIPTIONal
MUA21_RS12670	COG0456	acetyltransferase
MUA21_RS12705	COG5484	DNA packaging
MUA21_RS12705	COG3728	DNA packaging
MUA21_RS12800	COG0582	viral genome integration into host DNA
MUA21_RS12810	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MUA21_RS12820	COG0360	Binds together with S18 to 16S ribosomal RNA
MUA21_RS12830	COG0012	GTP binding
MUA21_RS12835	COG4481	Protein conserved in bacteria
MUA21_RS12840	COG0668	transmembrane transport
MUA21_RS12845	COG5609	conserved protein (DUF2294)
MUA21_RS12850	COG3002	Belongs to the UPF0753 family
MUA21_RS12855	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MUA21_RS12865	COG1131	(ABC) transporter
MUA21_RS12870	COG0577	efflux transmembrane transporter activity
MUA21_RS12870	COG1136	(ABC) transporter
MUA21_RS12875	COG1136	(ABC) transporter
MUA21_RS12890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MUA21_RS12900	COG2814	Major facilitator Superfamily
MUA21_RS12925	COG0772	Belongs to the SEDS family
MUA21_RS12955	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MUA21_RS12965	COG0529	Catalyzes the synthesis of activated sulfate
MUA21_RS12970	COG2046	Belongs to the sulfate adenylyltransferase family
MUA21_RS12975	COG0730	response to heat
MUA21_RS12990	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MUA21_RS12995	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MUA21_RS13000	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MUA21_RS13005	COG0175	sulfate reduction
MUA21_RS13035	COG1475	DNA binding
MUA21_RS13040	COG0626	cystathionine gamma-synthase activity
MUA21_RS13045	COG0626	cystathionine gamma-synthase activity
MUA21_RS13050	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MUA21_RS13050	COG0646	methionine synthase
MUA21_RS13055	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MUA21_RS13065	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MUA21_RS13085	COG0183	Belongs to the thiolase family
MUA21_RS13090	COG1250	3-hydroxyacyl-CoA dehydrogenase
MUA21_RS13090	COG1024	Enoyl-CoA hydratase
MUA21_RS13095	COG1960	acyl-CoA dehydrogenase activity
MUA21_RS13100	COG0318	PFAM AMP-dependent synthetase and ligase
MUA21_RS13110	COG0789	Transcriptional regulator
MUA21_RS13120	COG1028	Short-chain dehydrogenase reductase Sdr
MUA21_RS13140	COG0561	phosphatase activity
MUA21_RS13155	COG0697	spore germination
MUA21_RS13165	COG0531	amino acid
MUA21_RS13200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MUA21_RS13210	COG2271	Major facilitator Superfamily
MUA21_RS13220	COG1966	Carbon starvation protein
MUA21_RS13225	COG1475	DNA binding
MUA21_RS13230	COG0357	Ribosomal RNA small subunit methyltransferase G
MUA21_RS13235	COG0445	tRNA wobble uridine modification
MUA21_RS13240	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MUA21_RS13245	COG0594	ribonuclease P activity