locus-tag	class	description
DWB88_RS00175	COG0640	Transcriptional regulator
DWB88_RS00195	COG0446	pyridine nucleotide-disulphide oxidoreductase
DWB88_RS00210	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DWB88_RS00215	COG0730	response to heat
DWB88_RS00220	COG1937	Protein conserved in bacteria
DWB88_RS00230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DWB88_RS00240	COG1253	flavin adenine dinucleotide binding
DWB88_RS00250	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DWB88_RS00275	COG1388	LysM domain
DWB88_RS00280	COG2132	Multicopper oxidase
DWB88_RS00285	COG2217	Heavy metal translocating P-type atpase
DWB88_RS00330	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
DWB88_RS00355	COG2130	NADP-dependent
DWB88_RS00360	COG0702	epimerase
DWB88_RS00370	COG0789	Transcriptional regulator
DWB88_RS00375	COG0366	Alpha amylase catalytic
DWB88_RS00380	COG4716	Myosin-crossreactive antigen
DWB88_RS00410	COG1063	alcohol dehydrogenase
DWB88_RS00425	COG0579	oxidoreductase
DWB88_RS00435	COG3527	Alpha-acetolactate decarboxylase
DWB88_RS00440	COG0028	Belongs to the TPP enzyme family
DWB88_RS00460	COG1278	Cold shock
DWB88_RS00585	COG1278	Cold shock
DWB88_RS00640	COG2814	Major facilitator Superfamily
DWB88_RS00845	COG1192	Involved in chromosome partitioning
DWB88_RS00875	COG3682	Transcriptional regulator
DWB88_RS01040	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DWB88_RS01045	COG0592	DNA-directed DNA polymerase activity
DWB88_RS01050	COG2501	S4 domain
DWB88_RS01055	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DWB88_RS01060	COG0187	DNA topoisomerase II activity
DWB88_RS01065	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DWB88_RS01070	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DWB88_RS01085	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DWB88_RS01095	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DWB88_RS01110	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
DWB88_RS01115	COG0359	binds to the 23S rRNA
DWB88_RS01120	COG0305	Participates in initiation and elongation during chromosome replication
DWB88_RS01140	COG0745	RESPONSE REGULATOR receiver
DWB88_RS01145	COG5002	protein histidine kinase activity
DWB88_RS01150	COG4863	YycH protein
DWB88_RS01160	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DWB88_RS01170	COG1401	restriction endodeoxyribonuclease activity
DWB88_RS01195	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DWB88_RS01205	COG3223	Belongs to the PsiE family
DWB88_RS01215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWB88_RS01220	COG1733	regulation of RNA biosynthetic process
DWB88_RS01265	COG2851	Citrate transporter
DWB88_RS01270	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DWB88_RS01275	COG2814	Major facilitator Superfamily
DWB88_RS01280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DWB88_RS01290	COG2226	methyltransferase
DWB88_RS01295	COG5564	TIM-barrel signal transduction protein
DWB88_RS01305	COG5564	TIM-barrel signal transduction protein
DWB88_RS01330	COG2808	Putative FMN-binding domain
DWB88_RS01335	COG0110	maltose O-acetyltransferase activity
DWB88_RS01340	COG1114	Component of the transport system for branched-chain amino acids
DWB88_RS01345	COG2814	Major facilitator Superfamily
DWB88_RS01390	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DWB88_RS01395	COG1609	Transcriptional regulator
DWB88_RS01405	COG1869	D-ribose catabolic process
DWB88_RS01425	COG2814	Major facilitator Superfamily
DWB88_RS01445	COG1131	(ABC) transporter
DWB88_RS01475	COG0601	transmembrane transport
DWB88_RS01485	COG0444	Belongs to the ABC transporter superfamily
DWB88_RS01490	COG1124	(ABC) transporter
DWB88_RS01505	COG0346	lactoylglutathione lyase activity
DWB88_RS01515	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DWB88_RS01560	COG1250	3-hydroxyacyl-CoA dehydrogenase
DWB88_RS01565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DWB88_RS01585	COG2235	arginine
DWB88_RS01590	COG1438	arginine binding
DWB88_RS01595	COG0659	secondary active sulfate transmembrane transporter activity
DWB88_RS01615	COG2814	Major facilitator Superfamily
DWB88_RS01640	COG0438	transferase activity, transferring glycosyl groups
DWB88_RS01645	COG0653	protein targeting
DWB88_RS01655	COG1073	alpha beta
DWB88_RS01680	COG0747	negative chemotaxis
DWB88_RS01685	COG0601	transmembrane transport
DWB88_RS01690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWB88_RS01700	COG1124	(ABC) transporter
DWB88_RS01705	COG0789	Transcriptional regulator
DWB88_RS01710	COG0656	L-ascorbic acid biosynthetic process
DWB88_RS01725	COG2259	Doxx family
DWB88_RS01735	COG1959	2 iron, 2 sulfur cluster binding
DWB88_RS01740	COG2910	NAD(P)H-binding
DWB88_RS01745	COG1876	peptidase activity
DWB88_RS01750	COG1882	Formate acetyltransferase
DWB88_RS01755	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
DWB88_RS01770	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DWB88_RS01790	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DWB88_RS01840	COG1785	Belongs to the alkaline phosphatase family
DWB88_RS01875	COG0745	RESPONSE REGULATOR receiver
DWB88_RS01880	COG1131	(ABC) transporter
DWB88_RS01890	COG2205	protein histidine kinase activity
DWB88_RS01900	COG2720	vancomycin resistance protein
DWB88_RS01905	COG1136	(ABC) transporter
DWB88_RS01920	COG4221	oxidoreductase activity
DWB88_RS01925	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
DWB88_RS01930	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
DWB88_RS01935	COG2962	Rard protein
DWB88_RS01940	COG0471	metal ion transport
DWB88_RS01950	COG1695	Transcriptional regulator
DWB88_RS01965	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DWB88_RS01970	COG1054	Belongs to the UPF0176 family
DWB88_RS01995	COG1288	antiporter activity
DWB88_RS02000	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DWB88_RS02005	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DWB88_RS02020	COG2814	Major facilitator Superfamily
DWB88_RS02025	COG0737	Belongs to the 5'-nucleotidase family
DWB88_RS02040	COG3639	organic phosphonate transmembrane transporter activity
DWB88_RS02100	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DWB88_RS02120	COG2113	Glycine betaine
DWB88_RS02125	COG2409	Drug exporters of the RND superfamily
DWB88_RS02130	COG1764	response to oxidative stress
DWB88_RS02140	COG3942	CHAP domain
DWB88_RS02140	COG1705	Flagellar rod assembly protein muramidase FlgJ
DWB88_RS02160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DWB88_RS02170	COG0739	heme binding
DWB88_RS02195	COG3961	Belongs to the TPP enzyme family
DWB88_RS02220	COG0745	RESPONSE REGULATOR receiver
DWB88_RS02225	COG2205	protein histidine kinase activity
DWB88_RS02230	COG1136	(ABC) transporter
DWB88_RS02260	COG0175	sulfate reduction
DWB88_RS02265	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DWB88_RS02270	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DWB88_RS02285	COG0730	response to heat
DWB88_RS02290	COG2046	Belongs to the sulfate adenylyltransferase family
DWB88_RS02295	COG0529	Catalyzes the synthesis of activated sulfate
DWB88_RS02305	COG3942	CHAP domain
DWB88_RS02310	COG1328	CTP reductase activity
DWB88_RS02315	COG0602	queuosine metabolic process
DWB88_RS02320	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DWB88_RS02330	COG1510	regulation of RNA biosynthetic process
DWB88_RS02335	COG1012	belongs to the aldehyde dehydrogenase family
DWB88_RS02340	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DWB88_RS02345	COG1473	amidohydrolase
DWB88_RS02365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DWB88_RS02370	COG0574	Belongs to the PEP-utilizing enzyme family
DWB88_RS02370	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DWB88_RS02375	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DWB88_RS02380	COG0579	oxidoreductase
DWB88_RS02385	COG2723	6-phospho-beta-galactosidase activity
DWB88_RS02395	COG1695	Transcriptional regulator
DWB88_RS02410	COG0563	adenylate kinase activity
DWB88_RS02420	COG0446	pyridine nucleotide-disulphide oxidoreductase
DWB88_RS02445	COG0531	amino acid
DWB88_RS02455	COG0583	DNA-binding transcription factor activity
DWB88_RS02460	COG0039	L-malate dehydrogenase activity
DWB88_RS02465	COG0028	Belongs to the TPP enzyme family
DWB88_RS02470	COG3527	Alpha-acetolactate decarboxylase
DWB88_RS02480	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DWB88_RS02485	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DWB88_RS02500	COG4640	response to antibiotic
DWB88_RS02530	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DWB88_RS02545	COG3001	Fructosamine kinase
DWB88_RS02550	COG0596	Alpha beta hydrolase
DWB88_RS02560	COG4221	oxidoreductase activity
DWB88_RS02595	COG1113	amino acid transport
DWB88_RS02610	COG1388	LysM domain
DWB88_RS02625	COG0436	Aminotransferase
DWB88_RS02635	COG2608	mercury ion transmembrane transporter activity
DWB88_RS02650	COG1028	Short-chain dehydrogenase reductase Sdr
DWB88_RS02660	COG1012	belongs to the aldehyde dehydrogenase family
DWB88_RS02690	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DWB88_RS02695	COG3425	synthase
DWB88_RS02705	COG3942	CHAP domain
DWB88_RS02705	COG1388	LysM domain
DWB88_RS02715	COG0583	DNA-binding transcription factor activity
DWB88_RS02720	COG1380	Effector of murein hydrolase LrgA
DWB88_RS02725	COG1346	cytolysis
DWB88_RS02730	COG0028	Belongs to the TPP enzyme family
DWB88_RS02755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DWB88_RS02760	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DWB88_RS02765	COG0657	acetylesterase activity
DWB88_RS02775	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DWB88_RS02785	COG2843	Capsule synthesis protein
DWB88_RS02805	COG1070	Carbohydrate kinase
DWB88_RS02815	COG1760	l-serine dehydratase
DWB88_RS02820	COG1760	l-serine dehydratase
DWB88_RS02835	COG3764	Sortase (surface protein transpeptidase)
DWB88_RS02840	COG0561	phosphatase activity
DWB88_RS02850	COG0778	Nitroreductase
DWB88_RS02855	COG1012	belongs to the aldehyde dehydrogenase family
DWB88_RS02880	COG2514	catechol 2,3-dioxygenase activity
DWB88_RS02895	COG0583	DNA-binding transcription factor activity
DWB88_RS02900	COG1012	belongs to the aldehyde dehydrogenase family
DWB88_RS02905	COG3949	Membrane
DWB88_RS02915	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
DWB88_RS02920	COG0586	Pfam SNARE associated Golgi protein
DWB88_RS02925	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DWB88_RS02930	COG2022	thiamine diphosphate biosynthetic process
DWB88_RS02945	COG0352	thiamine-phosphate diphosphorylase activity
DWB88_RS02950	COG2271	Major facilitator Superfamily
DWB88_RS02955	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DWB88_RS02965	COG4876	unkown
DWB88_RS02970	COG2357	RelA SpoT domain protein
DWB88_RS02980	COG1802	Transcriptional regulator
DWB88_RS02985	COG1070	Carbohydrate kinase
DWB88_RS02990	COG2610	gluconate transmembrane transporter activity
DWB88_RS02995	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DWB88_RS03010	COG1215	transferase activity, transferring glycosyl groups
DWB88_RS03015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DWB88_RS03020	COG0494	nUDIX hydrolase
DWB88_RS03030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DWB88_RS03040	COG0022	dehydrogenase e1 component
DWB88_RS03045	COG0508	dehydrogenase complex catalyzes the overall conversion of
DWB88_RS03075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DWB88_RS03090	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DWB88_RS03095	COG1028	Short-chain dehydrogenase reductase Sdr
DWB88_RS03100	COG1363	Peptidase, m42
DWB88_RS03105	COG4808	Protein conserved in bacteria
DWB88_RS03125	COG0069	glutamate synthase activity
DWB88_RS03140	COG4619	ABC transporter
DWB88_RS03145	COG0390	transport system, permease component
DWB88_RS03150	COG2814	Major facilitator Superfamily
DWB88_RS03155	COG2272	Belongs to the type-B carboxylesterase lipase family
DWB88_RS03160	COG0531	amino acid
DWB88_RS03165	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
DWB88_RS03190	COG1174	glycine betaine transport
DWB88_RS03200	COG1380	Effector of murein hydrolase LrgA
DWB88_RS03210	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DWB88_RS03220	COG3477	response to acidic pH
DWB88_RS03240	COG0531	amino acid
DWB88_RS03250	COG1113	amino acid transport
DWB88_RS03255	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DWB88_RS03270	COG2814	Major facilitator Superfamily
DWB88_RS03275	COG1695	Transcriptional regulator
DWB88_RS03290	COG1929	Belongs to the glycerate kinase type-1 family
DWB88_RS03305	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DWB88_RS03310	COG0741	lytic transglycosylase activity
DWB88_RS03315	COG0588	phosphoglycerate mutase activity
DWB88_RS03325	COG2814	Major facilitator Superfamily
DWB88_RS03330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DWB88_RS03335	COG0765	amino acid transport
DWB88_RS03340	COG1126	abc transporter atp-binding protein
DWB88_RS03345	COG2348	transferase activity, transferring amino-acyl groups
DWB88_RS03360	COG0803	Belongs to the bacterial solute-binding protein 9 family
DWB88_RS03380	COG0454	-acetyltransferase
DWB88_RS03385	COG0747	negative chemotaxis
DWB88_RS03395	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DWB88_RS03400	COG2146	nitrite reductase [NAD(P)H] activity
DWB88_RS03410	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DWB88_RS03415	COG1140	nitrate reductase beta subunit
DWB88_RS03425	COG2181	nitrate reductase activity
DWB88_RS03435	COG4585	Histidine kinase
DWB88_RS03460	COG0778	Nitroreductase
DWB88_RS03470	COG1301	dicarboxylic acid transport
DWB88_RS03495	COG1263	PTS System
DWB88_RS03495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DWB88_RS03520	COG1028	Short-chain dehydrogenase reductase Sdr
DWB88_RS03525	COG0583	DNA-binding transcription factor activity
DWB88_RS03535	COG1028	Short-chain dehydrogenase reductase Sdr
DWB88_RS03565	COG0492	ferredoxin-NADP+ reductase activity
DWB88_RS03570	COG0456	acetyltransferase
DWB88_RS03575	COG0604	alcohol dehydrogenase
DWB88_RS03580	COG2822	iron ion transport
DWB88_RS03585	COG2837	iron assimilation
DWB88_RS03590	COG0672	)-iron permease
DWB88_RS03595	COG0805	protein transport
DWB88_RS03600	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DWB88_RS03610	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DWB88_RS03610	COG0463	Glycosyl transferase, family 2
DWB88_RS03620	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DWB88_RS03620	COG0463	Glycosyl transferase, family 2
DWB88_RS03625	COG1620	l-lactate permease
DWB88_RS03685	COG2814	Major facilitator Superfamily
DWB88_RS03695	COG1566	PFAM secretion protein HlyD family protein
DWB88_RS03700	COG2814	Major facilitator Superfamily
DWB88_RS03725	COG0598	Magnesium transport protein CorA
DWB88_RS03730	COG1304	FMN binding
DWB88_RS03735	COG0786	glutamate:sodium symporter activity
DWB88_RS03740	COG1695	Transcriptional regulator
DWB88_RS03755	COG2094	Belongs to the DNA glycosylase MPG family
DWB88_RS03765	COG1069	ribulokinase activity
DWB88_RS03770	COG4152	abc transporter atp-binding protein
DWB88_RS03775	COG1668	transmembrane transport
DWB88_RS03780	COG1742	UPF0060 membrane protein
DWB88_RS03785	COG2017	converts alpha-aldose to the beta-anomer
DWB88_RS03790	COG2258	MOSC domain
DWB88_RS03795	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DWB88_RS03810	COG0010	Belongs to the arginase family
DWB88_RS03815	COG0583	DNA-binding transcription factor activity
DWB88_RS03830	COG1473	amidohydrolase
DWB88_RS03835	COG1028	Short-chain dehydrogenase reductase Sdr
DWB88_RS03855	COG1737	Transcriptional regulator
DWB88_RS03860	COG1263	PTS System
DWB88_RS03860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DWB88_RS03870	COG0385	Bile acid
DWB88_RS03875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DWB88_RS03895	COG1113	amino acid transport
DWB88_RS03905	COG1263	PTS System
DWB88_RS03905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DWB88_RS03910	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DWB88_RS03930	COG2378	regulation of single-species biofilm formation
DWB88_RS03935	COG0483	inositol monophosphate 1-phosphatase activity
DWB88_RS03940	COG1316	TRANSCRIPTIONal
DWB88_RS03970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DWB88_RS03975	COG2076	Multidrug Resistance protein
DWB88_RS03980	COG2076	Multidrug Resistance protein
DWB88_RS03985	COG3942	CHAP domain
DWB88_RS04000	COG1757	Na H antiporter
DWB88_RS04005	COG3942	CHAP domain
DWB88_RS04015	COG1846	Transcriptional regulator
DWB88_RS04030	COG0829	nickel cation binding
DWB88_RS04045	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
DWB88_RS04050	COG0804	urea catabolic process
DWB88_RS04060	COG0831	urea catabolic process
DWB88_RS04065	COG4413	Urea transporter
DWB88_RS04070	COG0765	amino acid transport
DWB88_RS04075	COG0765	amino acid transport
DWB88_RS04085	COG1126	abc transporter atp-binding protein
DWB88_RS04090	COG1960	acyl-CoA dehydrogenase activity
DWB88_RS04105	COG1268	BioY protein
DWB88_RS04115	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DWB88_RS04125	COG4149	molybdate abc transporter
DWB88_RS04130	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DWB88_RS04135	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DWB88_RS04140	COG0521	Mo-molybdopterin cofactor biosynthetic process
DWB88_RS04145	COG0315	cyclic pyranopterin monophosphate synthase activity
DWB88_RS04155	COG1763	Mo-molybdopterin cofactor biosynthetic process
DWB88_RS04175	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DWB88_RS04185	COG2814	Major facilitator Superfamily
DWB88_RS04205	COG2348	transferase activity, transferring amino-acyl groups
DWB88_RS04210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DWB88_RS04230	COG4975	Glucose uptake
DWB88_RS04245	COG2252	PERMEase
DWB88_RS04260	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DWB88_RS04265	COG0088	Forms part of the polypeptide exit tunnel
DWB88_RS04270	COG0089	rRNA binding
DWB88_RS04280	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DWB88_RS04285	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DWB88_RS04290	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DWB88_RS04295	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DWB88_RS04305	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DWB88_RS04310	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DWB88_RS04315	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DWB88_RS04325	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DWB88_RS04330	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DWB88_RS04335	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DWB88_RS04340	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DWB88_RS04345	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DWB88_RS04350	COG1841	ribosomal large subunit assembly
DWB88_RS04360	COG0201	protein transport
DWB88_RS04365	COG0563	adenylate kinase activity
DWB88_RS04370	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DWB88_RS04380	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DWB88_RS04385	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DWB88_RS04390	COG0202	RNA polymerase activity
DWB88_RS04405	COG1122	ATPase activity
DWB88_RS04420	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DWB88_RS04435	COG0789	Transcriptional regulator
DWB88_RS04450	COG0698	ribose 5-phosphate isomerase
DWB88_RS04490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWB88_RS04495	COG2130	NADP-dependent
DWB88_RS04500	COG0604	alcohol dehydrogenase
DWB88_RS04505	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DWB88_RS04520	COG1302	Protein conserved in bacteria
DWB88_RS04530	COG2814	Major facilitator Superfamily
DWB88_RS04535	COG4264	IucA IucC family
DWB88_RS04540	COG3457	Alanine racemase
DWB88_RS04545	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DWB88_RS04555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB88_RS04560	COG3314	Sporulation integral membrane protein YlbJ
DWB88_RS04565	COG2329	Antibiotic biosynthesis monooxygenase
DWB88_RS04575	COG1988	membrane-bound metal-dependent
DWB88_RS04580	COG4284	Utp--glucose-1-phosphate uridylyltransferase
DWB88_RS04585	COG1272	protein, Hemolysin III
DWB88_RS04600	COG2814	Major facilitator Superfamily
DWB88_RS04605	COG0489	protein tyrosine kinase activity
DWB88_RS04660	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DWB88_RS04700	COG0561	phosphatase activity
DWB88_RS04720	COG0640	Transcriptional regulator
DWB88_RS04725	COG0702	epimerase
DWB88_RS04730	COG1482	cell wall glycoprotein biosynthetic process
DWB88_RS04750	COG0783	Belongs to the Dps family
DWB88_RS04755	COG0813	purine-nucleoside phosphorylase activity
DWB88_RS04760	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DWB88_RS04765	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DWB88_RS04770	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DWB88_RS04780	COG1854	S-ribosylhomocysteine lyase activity
DWB88_RS04800	COG5146	pantothenate kinase activity
DWB88_RS04815	COG0504	CTP synthase activity
DWB88_RS04825	COG0191	fructose-bisphosphate aldolase activity
DWB88_RS04830	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DWB88_RS04840	COG1012	belongs to the aldehyde dehydrogenase family
DWB88_RS04850	COG0254	rRNA binding
DWB88_RS04855	COG1435	thymidine kinase activity
DWB88_RS04865	COG2890	protein-(glutamine-N5) methyltransferase activity
DWB88_RS04870	COG0009	L-threonylcarbamoyladenylate synthase
DWB88_RS04875	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DWB88_RS04880	COG4475	Protein of unknown function (DUF436)
DWB88_RS04890	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DWB88_RS04895	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DWB88_RS04920	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DWB88_RS04930	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DWB88_RS04935	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DWB88_RS04940	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DWB88_RS04955	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DWB88_RS04970	COG0629	single-stranded DNA binding
DWB88_RS04975	COG1388	LysM domain
DWB88_RS04990	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DWB88_RS04995	COG0352	thiamine-phosphate diphosphorylase activity
DWB88_RS05000	COG0706	membrane insertase activity
DWB88_RS05010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DWB88_RS05015	COG1937	Protein conserved in bacteria
DWB88_RS05035	COG1181	Belongs to the D-alanine--D-alanine ligase family
DWB88_RS05040	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DWB88_RS05045	COG0513	Belongs to the DEAD box helicase family
DWB88_RS05055	COG3428	Bacterial PH domain
DWB88_RS05065	COG0736	holo-[acyl-carrier-protein] synthase activity
DWB88_RS05070	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DWB88_RS05080	COG2337	Toxic component of a toxin-antitoxin (TA) module
DWB88_RS05085	COG2208	phosphoserine phosphatase activity
DWB88_RS05095	COG1191	sigma factor activity
DWB88_RS05100	COG2183	response to ionizing radiation
DWB88_RS05145	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DWB88_RS05150	COG0473	3-isopropylmalate dehydrogenase activity
DWB88_RS05170	COG0028	Belongs to the TPP enzyme family
DWB88_RS05175	COG0129	dihydroxy-acid dehydratase activity
DWB88_RS05185	COG0802	atpase or kinase
DWB88_RS05190	COG1214	PFAM Peptidase M22, glycoprotease
DWB88_RS05195	COG0456	acetyltransferase
DWB88_RS05200	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DWB88_RS05225	COG2391	methyltransferase activity
DWB88_RS05230	COG0425	Belongs to the sulfur carrier protein TusA family
DWB88_RS05235	COG1609	Transcriptional regulator
DWB88_RS05240	COG1621	beta-fructofuranosidase activity
DWB88_RS05245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DWB88_RS05255	COG3290	protein histidine kinase activity
DWB88_RS05300	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DWB88_RS05305	COG0459	protein refolding
DWB88_RS05310	COG0582	viral genome integration into host DNA
DWB88_RS05480	COG1725	Transcriptional regulator
DWB88_RS05495	COG1131	(ABC) transporter
DWB88_RS05540	COG2706	6-phosphogluconolactonase activity
DWB88_RS05550	COG1012	belongs to the aldehyde dehydrogenase family
DWB88_RS05555	COG1227	inorganic diphosphatase activity
DWB88_RS05560	COG1335	isochorismatase
DWB88_RS05570	COG0077	Prephenate dehydratase
DWB88_RS05580	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DWB88_RS05585	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DWB88_RS05590	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
DWB88_RS05600	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DWB88_RS05605	COG4496	protein, YerC YecD
DWB88_RS05610	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
DWB88_RS05615	COG0210	DNA helicase
DWB88_RS05620	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DWB88_RS05630	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DWB88_RS05650	COG1597	lipid kinase activity
DWB88_RS05655	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DWB88_RS05675	COG1528	Iron-storage protein
DWB88_RS05690	COG4129	membrane
DWB88_RS05695	COG0024	Methionine aminopeptidase
DWB88_RS05715	COG2197	response regulator
DWB88_RS05720	COG1295	ribonuclease BN
DWB88_RS05735	COG4840	Belongs to the UPF0435 family
DWB88_RS05740	COG2309	aminopeptidase activity
DWB88_RS05750	COG0535	radical SAM domain protein
DWB88_RS05760	COG0693	protein deglycase activity
DWB88_RS05765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DWB88_RS05790	COG1988	membrane-bound metal-dependent
DWB88_RS05795	COG1194	a g-specific adenine glycosylase
DWB88_RS05800	COG3557	Belongs to the UPF0374 family
DWB88_RS05810	COG4129	membrane
DWB88_RS05815	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DWB88_RS05820	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DWB88_RS05825	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DWB88_RS05830	COG0735	belongs to the Fur family
DWB88_RS05995	COG0765	amino acid transport
DWB88_RS06005	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DWB88_RS06015	COG0363	glucosamine-6-phosphate deaminase activity
DWB88_RS06030	COG0114	fumarate hydratase activity
DWB88_RS06035	COG0564	pseudouridine synthase activity
DWB88_RS06040	COG4585	Histidine kinase
DWB88_RS06040	COG2203	Gaf domain
DWB88_RS06045	COG2197	response regulator
DWB88_RS06055	COG4399	Belongs to the UPF0754 family
DWB88_RS06060	COG3679	Belongs to the UPF0342 family
DWB88_RS06065	COG0420	3'-5' exonuclease activity
DWB88_RS06075	COG3481	metal-dependent phosphohydrolase, HD sub domain
DWB88_RS06100	COG0537	adenosine 5'-monophosphoramidase activity
DWB88_RS06105	COG1131	(ABC) transporter
DWB88_RS06110	COG4473	ABC transporter
DWB88_RS06115	COG2329	Antibiotic biosynthesis monooxygenase
DWB88_RS06125	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DWB88_RS06130	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DWB88_RS06135	COG3545	Serine hydrolase
DWB88_RS06185	COG0318	PFAM AMP-dependent synthetase and ligase
DWB88_RS06200	COG0494	nUDIX hydrolase
DWB88_RS06205	COG1506	peptidase
DWB88_RS06215	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DWB88_RS06230	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DWB88_RS06235	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DWB88_RS06245	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DWB88_RS06270	COG5632	N-Acetylmuramoyl-L-alanine amidase
DWB88_RS06270	COG3266	domain, Protein
DWB88_RS06270	COG4193	domain, Protein
DWB88_RS06280	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DWB88_RS06280	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DWB88_RS06285	COG0307	riboflavin synthase, alpha
DWB88_RS06290	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DWB88_RS06290	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DWB88_RS06295	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DWB88_RS06305	COG2267	carboxylic ester hydrolase activity
DWB88_RS06315	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DWB88_RS06320	COG1242	4 iron, 4 sulfur cluster binding
DWB88_RS06325	COG2814	Major facilitator Superfamily
DWB88_RS06330	COG0495	leucyl-tRNA aminoacylation
DWB88_RS06335	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DWB88_RS06350	COG2081	HI0933 family
DWB88_RS06355	COG2244	polysaccharide biosynthetic process
DWB88_RS06360	COG1187	pseudouridine synthase activity
DWB88_RS06370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DWB88_RS06375	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DWB88_RS06380	COG0510	thiamine kinase activity
DWB88_RS06385	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DWB88_RS06390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DWB88_RS06400	COG1363	Peptidase, m42
DWB88_RS06405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DWB88_RS06410	COG4848	Belongs to the UPF0354 family
DWB88_RS06415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DWB88_RS06420	COG1674	ftsk spoiiie
DWB88_RS06425	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DWB88_RS06440	COG1605	Chorismate mutase
DWB88_RS06440	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DWB88_RS06445	COG1609	Transcriptional regulator
DWB88_RS06455	COG0454	-acetyltransferase
DWB88_RS06460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DWB88_RS06470	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DWB88_RS06485	COG2814	Major facilitator Superfamily
DWB88_RS06490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DWB88_RS06495	COG0204	Acyl-transferase
DWB88_RS06515	COG1263	PTS System
DWB88_RS06515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DWB88_RS06525	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DWB88_RS06530	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DWB88_RS06540	COG0584	glycerophosphoryl diester phosphodiesterase
DWB88_RS06545	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DWB88_RS06555	COG1956	GAF domain-containing protein
DWB88_RS06560	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
DWB88_RS06570	COG0301	tRNA thio-modification
DWB88_RS06580	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DWB88_RS06585	COG0827	DNA restriction-modification system
DWB88_RS06590	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DWB88_RS06595	COG0589	response to stress
DWB88_RS06600	COG0686	Belongs to the AlaDH PNT family
DWB88_RS06605	COG0006	proline dipeptidase activity
DWB88_RS06610	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DWB88_RS06620	COG4109	DRTGG domain
DWB88_RS06625	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DWB88_RS06630	COG0587	DNA-directed DNA polymerase activity
DWB88_RS06635	COG0281	malic enzyme
DWB88_RS06640	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DWB88_RS06650	COG0205	6-phosphofructokinase activity
DWB88_RS06655	COG0469	pyruvate kinase activity
DWB88_RS06660	COG1113	amino acid transport
DWB88_RS06670	COG0538	isocitrate dehydrogenase activity
DWB88_RS06675	COG0745	RESPONSE REGULATOR receiver
DWB88_RS06685	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DWB88_RS06685	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DWB88_RS06690	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DWB88_RS06700	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DWB88_RS06705	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DWB88_RS06715	COG1484	DNA-dependent DNA replication
DWB88_RS06725	COG0833	amino acid
DWB88_RS06730	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DWB88_RS06735	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DWB88_RS06740	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DWB88_RS06745	COG4112	unkown
DWB88_RS06755	COG0544	peptidyl-prolyl cis-trans isomerase activity
DWB88_RS06760	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DWB88_RS06765	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DWB88_RS06770	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DWB88_RS06775	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DWB88_RS06780	COG0181	hydroxymethylbilane synthase activity
DWB88_RS06790	COG0113	porphobilinogen synthase activity
DWB88_RS06795	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DWB88_RS06805	COG2818	Glycosylase
DWB88_RS06810	COG0525	valine-tRNA ligase activity
DWB88_RS06815	COG0285	dihydrofolate synthase activity
DWB88_RS06825	COG2003	Belongs to the UPF0758 family
DWB88_RS06860	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DWB88_RS06865	COG2868	ribosomal protein
DWB88_RS06870	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DWB88_RS06875	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DWB88_RS06880	COG4492	Belongs to the UPF0735 family
DWB88_RS06885	COG0632	four-way junction helicase activity
DWB88_RS06895	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DWB88_RS06905	COG1862	Preprotein translocase
DWB88_RS06910	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DWB88_RS06910	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DWB88_RS06915	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DWB88_RS06915	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DWB88_RS06925	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DWB88_RS06935	COG0860	N-Acetylmuramoyl-L-alanine amidase
DWB88_RS06945	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DWB88_RS06955	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DWB88_RS06960	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DWB88_RS06965	COG1959	2 iron, 2 sulfur cluster binding
DWB88_RS06975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DWB88_RS06980	COG1104	cysteine desulfurase activity
DWB88_RS06985	COG0482	sulfurtransferase activity
DWB88_RS06995	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DWB88_RS07005	COG4472	Bacterial protein of unknown function (DUF965)
DWB88_RS07015	COG3906	Belongs to the UPF0473 family
DWB88_RS07025	COG0826	peptidase U32
DWB88_RS07030	COG0826	peptidase U32
DWB88_RS07035	COG0572	uridine kinase
DWB88_RS07040	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DWB88_RS07045	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DWB88_RS07050	COG1984	allophanate hydrolase subunit 2
DWB88_RS07055	COG0511	ligase activity, forming carbon-carbon bonds
DWB88_RS07060	COG0439	Biotin carboxylase
DWB88_RS07070	COG1914	H( )-stimulated, divalent metal cation uptake system
DWB88_RS07075	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DWB88_RS07080	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DWB88_RS07085	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DWB88_RS07090	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DWB88_RS07095	COG1534	Rna-binding protein
DWB88_RS07100	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DWB88_RS07105	COG1713	HD superfamily hydrolase involved in NAD metabolism
DWB88_RS07110	COG0799	negative regulation of ribosome biogenesis
DWB88_RS07125	COG2131	deaminase
DWB88_RS07130	COG2333	competence protein COMEC
DWB88_RS07130	COG0658	competence protein
DWB88_RS07135	COG1466	dna polymerase III delta subunit
DWB88_RS07140	COG0268	Binds directly to 16S ribosomal RNA
DWB88_RS07145	COG0481	GTPase activity
DWB88_RS07150	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DWB88_RS07160	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DWB88_RS07170	COG0484	heat shock protein binding
DWB88_RS07180	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DWB88_RS07185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DWB88_RS07195	COG1030	water channel activity
DWB88_RS07200	COG4864	UPF0365 protein
DWB88_RS07210	COG1702	phosphate starvation-inducible protein PhoH
DWB88_RS07230	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DWB88_RS07235	COG1381	Involved in DNA repair and RecF pathway recombination
DWB88_RS07240	COG0423	glycine-tRNA ligase activity
DWB88_RS07245	COG0517	IMP dehydrogenase activity
DWB88_RS07250	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DWB88_RS07260	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DWB88_RS07265	COG2384	SAM-dependent methyltransferase
DWB88_RS07270	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DWB88_RS07275	COG0513	Belongs to the DEAD box helicase family
DWB88_RS07280	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DWB88_RS07285	COG1121	(ABC) transporter
DWB88_RS07290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DWB88_RS07305	COG0768	penicillin binding
DWB88_RS07310	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DWB88_RS07325	COG4483	Protein conserved in bacteria
DWB88_RS07330	COG1940	carbohydrate kinase activity
DWB88_RS07335	COG0011	TIGRFAM Protein of
DWB88_RS07340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DWB88_RS07345	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DWB88_RS07350	COG1459	type II secretion system
DWB88_RS07355	COG4537	Required for transformation and DNA binding
DWB88_RS07375	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DWB88_RS07380	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DWB88_RS07395	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DWB88_RS07400	COG0095	Lipoate-protein ligase
DWB88_RS07415	COG0006	proline dipeptidase activity
DWB88_RS07420	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DWB88_RS07425	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DWB88_RS07430	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DWB88_RS07435	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DWB88_RS07440	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DWB88_RS07445	COG0511	ligase activity, forming carbon-carbon bonds
DWB88_RS07450	COG0439	Biotin carboxylase
DWB88_RS07455	COG1302	Protein conserved in bacteria
DWB88_RS07460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DWB88_RS07470	COG1722	exodeoxyribonuclease VII activity
DWB88_RS07475	COG0142	geranyltranstransferase activity
DWB88_RS07480	COG1438	arginine binding
DWB88_RS07485	COG0497	DNA recombination
DWB88_RS07490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DWB88_RS07500	COG0022	dehydrogenase e1 component
DWB88_RS07505	COG0508	dehydrogenase complex catalyzes the overall conversion of
DWB88_RS07515	COG4129	membrane
DWB88_RS07520	COG2195	Cleaves the N-terminal amino acid of tripeptides
DWB88_RS07525	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DWB88_RS07530	COG0366	Alpha amylase catalytic
DWB88_RS07540	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DWB88_RS07545	COG1234	tRNA 3'-trailer cleavage
DWB88_RS07550	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DWB88_RS07555	COG1028	Short-chain dehydrogenase reductase Sdr
DWB88_RS07560	COG0667	Aldo Keto reductase
DWB88_RS07565	COG0494	nUDIX hydrolase
DWB88_RS07570	COG0735	belongs to the Fur family
DWB88_RS07575	COG4974	Belongs to the 'phage' integrase family
DWB88_RS07585	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DWB88_RS07590	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DWB88_RS07595	COG1187	pseudouridine synthase activity
DWB88_RS07600	COG0745	RESPONSE REGULATOR receiver
DWB88_RS07615	COG1141	Ferredoxin
DWB88_RS07625	COG0514	ATP-dependent DNA helicase (RecQ)
DWB88_RS07635	COG0492	ferredoxin-NADP+ reductase activity
DWB88_RS07640	COG0252	asparaginase activity
DWB88_RS07645	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DWB88_RS07650	COG0539	negative regulation of cytoplasmic translation
DWB88_RS07655	COG1160	GTP binding
DWB88_RS07660	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DWB88_RS07675	COG2226	methyltransferase
DWB88_RS07690	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DWB88_RS07695	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DWB88_RS07710	COG5582	Belongs to the UPF0302 family
DWB88_RS07715	COG4347	Protein of unknown function (DUF1405)
DWB88_RS07720	COG2738	Putative neutral zinc metallopeptidase
DWB88_RS07725	COG1694	Mazg nucleotide pyrophosphohydrolase
DWB88_RS07730	COG0438	transferase activity, transferring glycosyl groups
DWB88_RS07735	COG0617	tRNA 3'-terminal CCA addition
DWB88_RS07740	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DWB88_RS07740	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DWB88_RS07745	COG1199	ATP-dependent helicase activity
DWB88_RS07745	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DWB88_RS07750	COG0017	Asparaginyl-tRNA synthetase
DWB88_RS07755	COG3935	DnaD domain protein
DWB88_RS07760	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DWB88_RS07775	COG3331	DNA recombination
DWB88_RS07790	COG3599	regulation of cell shape
DWB88_RS07800	COG0116	Belongs to the methyltransferase superfamily
DWB88_RS07810	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DWB88_RS07815	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DWB88_RS07850	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DWB88_RS07860	COG1413	lyase activity
DWB88_RS07865	COG1413	lyase activity
DWB88_RS07895	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DWB88_RS07900	COG2190	(PTS) system
DWB88_RS07910	COG0793	Belongs to the peptidase S41A family
DWB88_RS07920	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DWB88_RS07925	COG0671	phosphoesterase, PA-phosphatase related
DWB88_RS07930	COG0745	RESPONSE REGULATOR receiver
DWB88_RS07935	COG5002	protein histidine kinase activity
DWB88_RS07940	COG0567	Dehydrogenase, E1 component
DWB88_RS07945	COG0508	dehydrogenase complex catalyzes the overall conversion of
DWB88_RS07950	COG1131	(ABC) transporter
DWB88_RS07975	COG0714	Associated with various cellular activities
DWB88_RS07980	COG4548	von Willebrand factor, type A
DWB88_RS07985	COG1114	Component of the transport system for branched-chain amino acids
DWB88_RS07990	COG3853	Toxic anion resistance protein (TelA)
DWB88_RS08000	COG1254	Belongs to the acylphosphatase family
DWB88_RS08015	COG1278	Cold shock
DWB88_RS08030	COG1473	amidohydrolase
DWB88_RS08040	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DWB88_RS08045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DWB88_RS08050	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DWB88_RS08055	COG0527	aspartate kinase activity
DWB88_RS08060	COG0488	(ABC) transporter
DWB88_RS08065	COG2996	Protein conserved in bacteria
DWB88_RS08070	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DWB88_RS08075	COG0573	inorganic phosphate transmembrane transporter activity
DWB88_RS08085	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DWB88_RS08125	COG4607	ABC-type enterochelin transport system periplasmic component
DWB88_RS08130	COG0561	phosphatase activity
DWB88_RS08135	COG2348	transferase activity, transferring amino-acyl groups
DWB88_RS08140	COG2348	transferase activity, transferring amino-acyl groups
DWB88_RS08160	COG0134	indole-3-glycerol-phosphate synthase activity
DWB88_RS08170	COG0512	Glutamine amidotransferase of anthranilate synthase
DWB88_RS08175	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DWB88_RS08180	COG1363	Peptidase, m42
DWB88_RS08185	COG0287	Prephenate dehydrogenase
DWB88_RS08190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DWB88_RS08195	COG1942	4-Oxalocrotonate Tautomerase
DWB88_RS08210	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DWB88_RS08210	COG0392	lysyltransferase activity
DWB88_RS08215	COG0628	permease
DWB88_RS08220	COG3711	transcriptional antiterminator
DWB88_RS08225	COG1115	amino acid carrier protein
DWB88_RS08230	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DWB88_RS08235	COG0187	DNA topoisomerase II activity
DWB88_RS08250	COG0824	Thioesterase
DWB88_RS08255	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DWB88_RS08260	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DWB88_RS08265	COG1970	mechanosensitive ion channel activity
DWB88_RS08290	COG3763	UPF0154 protein
DWB88_RS08300	COG4224	UPF0291 protein
DWB88_RS08325	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DWB88_RS08340	COG0833	amino acid
DWB88_RS08355	COG0083	homoserine kinase activity
DWB88_RS08360	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DWB88_RS08365	COG0460	homoserine dehydrogenase
DWB88_RS08370	COG0527	aspartate kinase activity
DWB88_RS08385	COG1525	nuclease
DWB88_RS08395	COG2197	response regulator
DWB88_RS08410	COG1131	(ABC) transporter
DWB88_RS08450	COG0789	Transcriptional regulator
DWB88_RS08455	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DWB88_RS08460	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DWB88_RS08465	COG0386	Belongs to the glutathione peroxidase family
DWB88_RS08470	COG1923	regulation of RNA biosynthetic process
DWB88_RS08475	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DWB88_RS08500	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
DWB88_RS08520	COG4550	Control of competence regulator ComK, YlbF/YmcA
DWB88_RS08535	COG4195	phage-related replication protein
DWB88_RS08540	COG1013	pyruvate-flavodoxin oxidoreductase activity
DWB88_RS08545	COG0674	pyruvate-flavodoxin oxidoreductase activity
DWB88_RS08545	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DWB88_RS08550	COG1692	metallophosphoesterase
DWB88_RS08560	COG1418	mRNA catabolic process
DWB88_RS08565	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DWB88_RS08580	COG1426	Protein conserved in bacteria
DWB88_RS08590	COG1028	Short-chain dehydrogenase reductase Sdr
DWB88_RS08595	COG0612	Peptidase, M16
DWB88_RS08600	COG0612	Peptidase, M16
DWB88_RS08605	COG2188	Transcriptional regulator
DWB88_RS08615	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DWB88_RS08620	COG1185	polyribonucleotide nucleotidyltransferase activity
DWB88_RS08625	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DWB88_RS08630	COG0196	riboflavin kinase activity
DWB88_RS08635	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DWB88_RS08640	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DWB88_RS08655	COG1358	cellular component organization or biogenesis
DWB88_RS08660	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DWB88_RS08665	COG0195	Participates in both transcription termination and antitermination
DWB88_RS08675	COG2176	DNA-directed DNA polymerase activity
DWB88_RS08680	COG0442	prolyl-tRNA aminoacylation
DWB88_RS08690	COG4589	Belongs to the CDS family
DWB88_RS08700	COG0233	cytoplasmic translational termination
DWB88_RS08705	COG0528	UMP kinase activity
DWB88_RS08710	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DWB88_RS08715	COG0052	Belongs to the universal ribosomal protein uS2 family
DWB88_RS08730	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DWB88_RS08735	COG4974	Belongs to the 'phage' integrase family
DWB88_RS08740	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DWB88_RS08745	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DWB88_RS08750	COG0758	DNA mediated transformation
DWB88_RS08755	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DWB88_RS08760	COG0045	succinate-CoA ligase (ADP-forming) activity
DWB88_RS08765	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DWB88_RS08790	COG0336	Belongs to the RNA methyltransferase TrmD family
DWB88_RS08795	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DWB88_RS08800	COG0228	four-way junction DNA binding
DWB88_RS08805	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DWB88_RS08810	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DWB88_RS08815	COG0552	protein localization to endoplasmic reticulum
DWB88_RS08820	COG1196	nuclear chromosome segregation
DWB88_RS08825	COG0571	ribonuclease III activity
DWB88_RS08830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DWB88_RS08850	COG1349	DNA-binding transcription factor activity
DWB88_RS08855	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DWB88_RS08860	COG1461	Dihydroxyacetone kinase
DWB88_RS08865	COG1302	Protein conserved in bacteria
DWB88_RS08870	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DWB88_RS08880	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DWB88_RS08895	COG0631	protein serine/threonine phosphatase activity
DWB88_RS08900	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DWB88_RS08905	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DWB88_RS08905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DWB88_RS08910	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DWB88_RS08915	COG0242	peptide deformylase activity
DWB88_RS08930	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DWB88_RS08935	COG1758	RNA polymerase activity
DWB88_RS08960	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DWB88_RS08965	COG0284	orotidine-5'-phosphate decarboxylase activity
DWB88_RS08970	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DWB88_RS08975	COG0505	Belongs to the CarA family
DWB88_RS08980	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DWB88_RS08985	COG0540	Belongs to the ATCase OTCase family
DWB88_RS08990	COG2233	PERMEase
DWB88_RS08995	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DWB88_RS09005	COG0564	pseudouridine synthase activity
DWB88_RS09015	COG1388	LysM domain
DWB88_RS09015	COG3942	CHAP domain
DWB88_RS09025	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DWB88_RS09030	COG3599	regulation of cell shape
DWB88_RS09040	COG0762	integral membrane protein
DWB88_RS09045	COG1799	cell septum assembly
DWB88_RS09050	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DWB88_RS09055	COG1496	oxidoreductase activity
DWB88_RS09060	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DWB88_RS09065	COG0849	cell division
DWB88_RS09080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DWB88_RS09085	COG0768	penicillin binding
DWB88_RS09090	COG4839	cell division protein FtsL
DWB88_RS09095	COG0275	rRNA processing
DWB88_RS09105	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
DWB88_RS09115	COG1011	Hydrolase
DWB88_RS09230	COG5434	Belongs to the glycosyl hydrolase 28 family
DWB88_RS09295	COG0740	serine-type endopeptidase activity
DWB88_RS09305	COG4626	Terminase
DWB88_RS09305	COG1802	Transcriptional regulator
DWB88_RS09375	COG1525	nuclease
DWB88_RS09425	COG0305	Participates in initiation and elongation during chromosome replication
DWB88_RS09490	COG1476	TRANSCRIPTIONal
DWB88_RS09505	COG0582	viral genome integration into host DNA
DWB88_RS09515	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DWB88_RS09520	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DWB88_RS09525	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DWB88_RS09530	COG1053	succinate dehydrogenase
DWB88_RS09535	COG2009	succinate dehydrogenase
DWB88_RS09540	COG0322	excinuclease ABC activity
DWB88_RS09545	COG3118	belongs to the thioredoxin family
DWB88_RS09565	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DWB88_RS09570	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DWB88_RS09575	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DWB88_RS09575	COG0072	phenylalanine-tRNA ligase activity
DWB88_RS09580	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DWB88_RS09585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DWB88_RS09590	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DWB88_RS09605	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DWB88_RS09610	COG0742	ribosomal rna small subunit methyltransferase
DWB88_RS09625	COG0584	glycerophosphoryl diester phosphodiesterase
DWB88_RS09630	COG3679	Belongs to the UPF0342 family
DWB88_RS09645	COG0109	protoheme IX farnesyltransferase activity
DWB88_RS09650	COG1612	heme a metabolic process
DWB88_RS09660	COG0772	Belongs to the SEDS family
DWB88_RS09665	COG4838	Belongs to the UPF0358 family
DWB88_RS09670	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DWB88_RS09675	COG4896	Protein conserved in bacteria
DWB88_RS09690	COG0483	inositol monophosphate 1-phosphatase activity
DWB88_RS09695	COG4493	Belongs to the UPF0637 family
DWB88_RS09725	COG1176	ABC-type spermidine putrescine transport system, permease component I
DWB88_RS09740	COG4476	Belongs to the UPF0223 family
DWB88_RS09750	COG0508	dehydrogenase complex catalyzes the overall conversion of
DWB88_RS09770	COG0242	peptide deformylase activity
DWB88_RS09775	COG5503	Protein of unknown function (DUF1447)
DWB88_RS09780	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DWB88_RS09785	COG0569	domain protein
DWB88_RS09790	COG1294	oxidase, subunit
DWB88_RS09795	COG1271	oxidase subunit
DWB88_RS09805	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DWB88_RS09810	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DWB88_RS09820	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DWB88_RS09840	COG4172	Belongs to the ABC transporter superfamily
DWB88_RS09845	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DWB88_RS09855	COG0138	bifunctional purine biosynthesis protein purh
DWB88_RS09865	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DWB88_RS09880	COG0047	phosphoribosylformylglycinamidine synthase activity
DWB88_RS09885	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DWB88_RS09890	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DWB88_RS09900	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DWB88_RS09905	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DWB88_RS09910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DWB88_RS09910	COG1017	nitric oxide dioxygenase activity
DWB88_RS09920	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DWB88_RS09935	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DWB88_RS09975	COG3594	Acyltransferase
DWB88_RS09985	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DWB88_RS09995	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DWB88_RS10000	COG1169	isochorismate synthase
DWB88_RS10005	COG1575	Belongs to the MenA family. Type 1 subfamily
DWB88_RS10010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DWB88_RS10015	COG2314	TM2 domain
DWB88_RS10050	COG4873	Protein conserved in bacteria
DWB88_RS10065	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DWB88_RS10070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DWB88_RS10075	COG0861	Integral membrane protein TerC family
DWB88_RS10080	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DWB88_RS10090	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DWB88_RS10095	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DWB88_RS10100	COG2814	Major facilitator Superfamily
DWB88_RS10105	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DWB88_RS10110	COG2382	esterase
DWB88_RS10115	COG1115	amino acid carrier protein
DWB88_RS10120	COG0628	permease
DWB88_RS10130	COG0475	glutathione-regulated potassium exporter activity
DWB88_RS10130	COG0569	domain protein
DWB88_RS10135	COG2239	Acts as a magnesium transporter
DWB88_RS10140	COG0564	pseudouridine synthase activity
DWB88_RS10145	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DWB88_RS10150	COG2357	RelA SpoT domain protein
DWB88_RS10165	COG2346	COG2346, Truncated hemoglobins
DWB88_RS10170	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DWB88_RS10175	COG1164	Oligoendopeptidase f
DWB88_RS10185	COG4862	establishment of competence for transformation
DWB88_RS10190	COG1393	Belongs to the ArsC family
DWB88_RS10195	COG0180	Tryptophanyl-tRNA synthetase
DWB88_RS10205	COG4608	Belongs to the ABC transporter superfamily
DWB88_RS10210	COG0444	Belongs to the ABC transporter superfamily
DWB88_RS10215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DWB88_RS10220	COG0601	transmembrane transport
DWB88_RS10235	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DWB88_RS10245	COG0542	response to heat
DWB88_RS10260	COG0561	phosphatase activity
DWB88_RS10265	COG0446	pyridine nucleotide-disulphide oxidoreductase
DWB88_RS10280	COG1074	ATP-dependent DNA helicase activity
DWB88_RS10300	COG0398	Pfam SNARE associated Golgi protein
DWB88_RS10310	COG0137	argininosuccinate synthase activity
DWB88_RS10315	COG0165	Argininosuccinate lyase
DWB88_RS10325	COG0584	glycerophosphoryl diester phosphodiesterase
DWB88_RS10345	COG1902	pentaerythritol trinitrate reductase activity
DWB88_RS10350	COG1098	S1 RNA binding domain
DWB88_RS10365	COG2111	Na H antiporter
DWB88_RS10365	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DWB88_RS10370	COG2111	Na H antiporter
DWB88_RS10375	COG1006	Multisubunit Na H antiporter MnhC subunit
DWB88_RS10380	COG0651	ATP synthesis coupled electron transport
DWB88_RS10390	COG2212	antiporter activity
DWB88_RS10410	COG2050	protein possibly involved in aromatic compounds catabolism
DWB88_RS10415	COG2056	Na+-H+ antiporter family
DWB88_RS10420	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DWB88_RS10430	COG0316	Belongs to the HesB IscA family
DWB88_RS10435	COG4844	belongs to the
DWB88_RS10440	COG1252	NADH dehydrogenase
DWB88_RS10445	COG4837	Protein of unknown function (DUF1462)
DWB88_RS10450	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DWB88_RS10455	COG0583	DNA-binding transcription factor activity
DWB88_RS10465	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DWB88_RS10475	COG1696	Membrane protein involved in D-alanine export
DWB88_RS10480	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DWB88_RS10500	COG2445	Protein of unknown function DUF86
DWB88_RS10510	COG4470	Protein conserved in bacteria
DWB88_RS10515	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DWB88_RS10520	COG0737	Belongs to the 5'-nucleotidase family
DWB88_RS10525	COG0730	response to heat
DWB88_RS10530	COG1801	Protein of unknown function DUF72
DWB88_RS10535	COG2070	2-Nitropropane dioxygenase
DWB88_RS10540	COG1253	flavin adenine dinucleotide binding
DWB88_RS10545	COG0719	Fe-S assembly protein
DWB88_RS10550	COG0822	iron-sulfur transferase activity
DWB88_RS10555	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DWB88_RS10560	COG0719	Fe-S assembly protein
DWB88_RS10565	COG0396	ATPase activity
DWB88_RS10575	COG3237	CsbD-like
DWB88_RS10580	COG1464	Belongs to the NlpA lipoprotein family
DWB88_RS10585	COG2011	ABC-type metal ion transport system permease component
DWB88_RS10590	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DWB88_RS10600	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DWB88_RS10605	COG0509	glycine decarboxylation via glycine cleavage system
DWB88_RS10610	COG1393	Belongs to the ArsC family
DWB88_RS10615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DWB88_RS10625	COG0710	3-dehydroquinate dehydratase activity
DWB88_RS10630	COG1764	response to oxidative stress
DWB88_RS10645	COG0406	alpha-ribazole phosphatase activity
DWB88_RS10680	COG4195	phage-related replication protein
DWB88_RS10705	COG1278	Cold shock
DWB88_RS10730	COG0656	L-ascorbic acid biosynthetic process
DWB88_RS10735	COG1309	transcriptional regulator
DWB88_RS10805	COG0557	exoribonuclease II activity
DWB88_RS10810	COG1647	Serine aminopeptidase, S33
DWB88_RS10815	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DWB88_RS10825	COG0148	phosphopyruvate hydratase activity
DWB88_RS10830	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DWB88_RS10835	COG0149	triose-phosphate isomerase activity
DWB88_RS10840	COG0126	phosphoglycerate kinase activity
DWB88_RS10850	COG2390	Transcriptional regulator
DWB88_RS10875	COG0740	serine-type endopeptidase activity
DWB88_RS10885	COG1481	regulation of sporulation
DWB88_RS10890	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DWB88_RS10895	COG1660	Displays ATPase and GTPase activities
DWB88_RS10900	COG0492	ferredoxin-NADP+ reductase activity
DWB88_RS10915	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DWB88_RS10925	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DWB88_RS10945	COG3942	CHAP domain
DWB88_RS10945	COG1388	LysM domain
DWB88_RS10955	COG0653	protein targeting
DWB88_RS10960	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DWB88_RS10965	COG1040	competence protein
DWB88_RS10970	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DWB88_RS10980	COG1739	Uncharacterized protein family UPF0029
DWB88_RS11005	COG2195	Cleaves the N-terminal amino acid of tripeptides
DWB88_RS11010	COG1929	Belongs to the glycerate kinase type-1 family
DWB88_RS11030	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DWB88_RS11045	COG4604	ABC transporter, ATP-binding protein
DWB88_RS11050	COG4605	iron ion homeostasis
DWB88_RS11055	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB88_RS11060	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DWB88_RS11065	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DWB88_RS11070	COG1780	Probably involved in ribonucleotide reductase function
DWB88_RS11090	COG1597	lipid kinase activity
DWB88_RS11100	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DWB88_RS11105	COG1174	glycine betaine transport
DWB88_RS11110	COG0517	IMP dehydrogenase activity
DWB88_RS11110	COG1125	glycine betaine transport
DWB88_RS11115	COG0514	ATP-dependent DNA helicase (RecQ)
DWB88_RS11120	COG0488	(ABC) transporter
DWB88_RS11130	COG1368	sulfuric ester hydrolase activity
DWB88_RS11160	COG0512	Glutamine amidotransferase of anthranilate synthase
DWB88_RS11160	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DWB88_RS11165	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DWB88_RS11170	COG0720	synthase
DWB88_RS11175	COG0602	queuosine metabolic process
DWB88_RS11185	COG0463	Glycosyl transferase, family 2
DWB88_RS11190	COG0656	L-ascorbic acid biosynthetic process
DWB88_RS11195	COG1253	flavin adenine dinucleotide binding
DWB88_RS11200	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DWB88_RS11205	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DWB88_RS11205	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DWB88_RS11205	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DWB88_RS11210	COG1105	Belongs to the carbohydrate kinase PfkB family
DWB88_RS11215	COG1349	DNA-binding transcription factor activity
DWB88_RS11220	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DWB88_RS11245	COG0415	Belongs to the DNA photolyase family
DWB88_RS11250	COG0471	metal ion transport
DWB88_RS11255	COG0039	L-malate dehydrogenase activity
DWB88_RS11265	COG4989	oxidoreductase activity
DWB88_RS11270	COG0523	cobalamin synthesis protein
DWB88_RS11280	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DWB88_RS11285	COG4988	ABC transporter
DWB88_RS11290	COG1968	undecaprenyl-diphosphatase activity
DWB88_RS11300	COG1671	Belongs to the UPF0178 family
DWB88_RS11305	COG1611	Belongs to the LOG family
DWB88_RS11320	COG1959	2 iron, 2 sulfur cluster binding
DWB88_RS11330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DWB88_RS11355	COG2839	Protein conserved in bacteria
DWB88_RS11360	COG2814	Major facilitator Superfamily
DWB88_RS11365	COG0583	DNA-binding transcription factor activity
DWB88_RS11380	COG0217	transcriptional regulatory protein
DWB88_RS11390	COG0662	Cupin 2, conserved barrel domain protein
DWB88_RS11390	COG2207	Transcriptional regulator
DWB88_RS11400	COG1388	LysM domain
DWB88_RS11400	COG3942	CHAP domain
DWB88_RS11410	COG0306	phosphate transporter
DWB88_RS11415	COG1392	Phosphate transport regulator
DWB88_RS11425	COG0577	efflux transmembrane transporter activity
DWB88_RS11430	COG1136	(ABC) transporter
DWB88_RS11435	COG2205	protein histidine kinase activity
DWB88_RS11455	COG0657	acetylesterase activity
DWB88_RS11460	COG3949	Membrane
DWB88_RS11470	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
DWB88_RS11480	COG2376	Dihydroxyacetone kinase
DWB88_RS11485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB88_RS11490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB88_RS11495	COG1120	ATPase activity
DWB88_RS11500	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DWB88_RS11505	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DWB88_RS11510	COG1132	(ABC) transporter
DWB88_RS11515	COG1686	Belongs to the peptidase S11 family
DWB88_RS11520	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DWB88_RS11530	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DWB88_RS11535	COG1682	transport, permease protein
DWB88_RS11545	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
DWB88_RS11560	COG1121	(ABC) transporter
DWB88_RS11565	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DWB88_RS11570	COG0803	Belongs to the bacterial solute-binding protein 9 family
DWB88_RS11580	COG1320	monovalent cation:proton antiporter activity
DWB88_RS11590	COG1863	multisubunit Na H antiporter MnhE subunit
DWB88_RS11600	COG1006	Multisubunit Na H antiporter MnhC subunit
DWB88_RS11605	COG2111	Na H antiporter
DWB88_RS11610	COG2111	Na H antiporter
DWB88_RS11610	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DWB88_RS11645	COG2267	carboxylic ester hydrolase activity
DWB88_RS11665	COG0546	phosphoglycolate phosphatase activity
DWB88_RS11670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DWB88_RS11675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DWB88_RS11680	COG0534	Mate efflux family protein
DWB88_RS11690	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DWB88_RS11695	COG0018	arginyl-trna synthetase
DWB88_RS11720	COG1078	dGTPase activity
DWB88_RS11730	COG0655	NAD(P)H dehydrogenase (quinone) activity
DWB88_RS11735	COG0667	Aldo Keto reductase
DWB88_RS11740	COG4844	belongs to the
DWB88_RS11755	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DWB88_RS11760	COG0095	Lipoate-protein ligase
DWB88_RS11765	COG0280	phosphate acetyltransferase
DWB88_RS11770	COG3253	May function as heme-dependent peroxidase
DWB88_RS11790	COG2363	Small membrane protein
DWB88_RS11805	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DWB88_RS11825	COG0477	Major facilitator Superfamily
DWB88_RS11840	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DWB88_RS11845	COG0363	glucosamine-6-phosphate deaminase activity
DWB88_RS11855	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DWB88_RS11860	COG1469	GTP cyclohydrolase I activity
DWB88_RS11865	COG2271	Major facilitator Superfamily
DWB88_RS11890	COG0431	NADPH-dependent FMN reductase
DWB88_RS11895	COG0561	phosphatase activity
DWB88_RS11910	COG1428	Deoxynucleoside kinase
DWB88_RS11915	COG0546	phosphoglycolate phosphatase activity
DWB88_RS11920	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DWB88_RS11945	COG1063	alcohol dehydrogenase
DWB88_RS11950	COG2814	Major facilitator Superfamily
DWB88_RS11955	COG1349	DNA-binding transcription factor activity
DWB88_RS11980	COG1473	amidohydrolase
DWB88_RS11985	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DWB88_RS11995	COG0049	tRNA binding
DWB88_RS12000	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DWB88_RS12010	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DWB88_RS12015	COG0085	RNA polymerase activity
DWB88_RS12025	COG0222	ribosome binding
DWB88_RS12030	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DWB88_RS12045	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DWB88_RS12050	COG0250	Participates in transcription elongation, termination and antitermination
DWB88_RS12060	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DWB88_RS12070	COG3688	RNA-binding protein containing a PIN domain
DWB88_RS12080	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
DWB88_RS12085	COG0215	cysteine-tRNA ligase activity
DWB88_RS12100	COG4956	integral membrane protein (PIN domain superfamily)
DWB88_RS12105	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DWB88_RS12110	COG0542	response to heat
DWB88_RS12120	COG3880	PFAM UvrB UvrC protein
DWB88_RS12130	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DWB88_RS12135	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DWB88_RS12140	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DWB88_RS12230	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DWB88_RS12235	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DWB88_RS12240	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DWB88_RS12260	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DWB88_RS12275	COG1098	S1 RNA binding domain
DWB88_RS12285	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DWB88_RS12295	COG2244	polysaccharide biosynthetic process
DWB88_RS12300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DWB88_RS12305	COG0193	aminoacyl-tRNA hydrolase activity
DWB88_RS12310	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DWB88_RS12315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DWB88_RS12320	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DWB88_RS12325	COG2088	sporulation resulting in formation of a cellular spore
DWB88_RS12335	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DWB88_RS12340	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DWB88_RS12345	COG4466	Protein conserved in bacteria
DWB88_RS12350	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DWB88_RS12355	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DWB88_RS12360	COG0084	hydrolase, TatD family'
DWB88_RS12365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DWB88_RS12365	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DWB88_RS12370	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DWB88_RS12375	COG2827	Endonuclease containing a URI domain
DWB88_RS12380	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DWB88_RS12385	COG4467	Involved in initiation control of chromosome replication
DWB88_RS12390	COG1774	PSP1 C-terminal conserved region
DWB88_RS12400	COG3870	Protein conserved in bacteria
DWB88_RS12410	COG1982	Orn Lys Arg decarboxylase major
DWB88_RS12415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DWB88_RS12435	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DWB88_RS12440	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DWB88_RS12445	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DWB88_RS12460	COG2188	Transcriptional regulator
DWB88_RS12470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DWB88_RS12470	COG1263	PTS System
DWB88_RS12480	COG0493	'glutamate synthase
DWB88_RS12485	COG0067	glutamate synthase
DWB88_RS12485	COG0069	glutamate synthase activity
DWB88_RS12485	COG0070	glutamate synthase
DWB88_RS12505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DWB88_RS12510	COG0494	nUDIX hydrolase
DWB88_RS12520	COG0438	transferase activity, transferring glycosyl groups
DWB88_RS12535	COG1278	Cold shock
DWB88_RS12540	COG3759	membrane
DWB88_RS12565	COG1846	Transcriptional regulator
DWB88_RS12570	COG0626	cystathionine gamma-synthase activity
DWB88_RS12575	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DWB88_RS12595	COG0733	neurotransmitter:sodium symporter activity
DWB88_RS12610	COG0671	phosphoesterase, PA-phosphatase related
DWB88_RS12625	COG5609	conserved protein (DUF2294)
DWB88_RS12630	COG3002	Belongs to the UPF0753 family
DWB88_RS12635	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DWB88_RS12650	COG0523	cobalamin synthesis protein
DWB88_RS12660	COG0519	Catalyzes the synthesis of GMP from XMP
DWB88_RS12660	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DWB88_RS12665	COG0517	IMP dehydrogenase activity
DWB88_RS12665	COG0516	GMP reductase activity
DWB88_RS12670	COG2233	PERMEase
DWB88_RS12675	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DWB88_RS12700	COG1823	symporter activity
DWB88_RS12705	COG0778	Nitroreductase
DWB88_RS12710	COG0450	alkyl hydroperoxide reductase
DWB88_RS12715	COG3634	alkyl hydroperoxide reductase activity
DWB88_RS12740	COG1280	lysine exporter protein (LysE YggA)
DWB88_RS12850	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DWB88_RS12860	COG0360	Binds together with S18 to 16S ribosomal RNA
DWB88_RS12875	COG0012	GTP binding
DWB88_RS12880	COG4481	Protein conserved in bacteria
DWB88_RS12885	COG0668	transmembrane transport
DWB88_RS12890	COG1475	DNA binding
DWB88_RS12900	COG0626	cystathionine gamma-synthase activity
DWB88_RS12905	COG0626	cystathionine gamma-synthase activity
DWB88_RS12915	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DWB88_RS12935	COG3942	CHAP domain
DWB88_RS12945	COG0183	Belongs to the thiolase family
DWB88_RS12950	COG3250	beta-galactosidase activity
DWB88_RS12955	COG1028	Short-chain dehydrogenase reductase Sdr
DWB88_RS12960	COG1312	Catalyzes the dehydration of D-mannonate
DWB88_RS12965	COG1904	glucuronate isomerase
DWB88_RS12970	COG2211	Major facilitator Superfamily
DWB88_RS12980	COG0800	Aldolase
DWB88_RS12985	COG2207	Transcriptional regulator
DWB88_RS13030	COG1476	TRANSCRIPTIONal
DWB88_RS13040	COG1131	(ABC) transporter
DWB88_RS13060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DWB88_RS13080	COG1136	(ABC) transporter
DWB88_RS13085	COG0577	efflux transmembrane transporter activity
DWB88_RS13165	COG2348	transferase activity, transferring amino-acyl groups
DWB88_RS13175	COG1063	alcohol dehydrogenase
DWB88_RS13180	COG0577	efflux transmembrane transporter activity
DWB88_RS13185	COG1136	(ABC) transporter
DWB88_RS13225	COG1475	DNA binding
DWB88_RS13230	COG0357	Ribosomal RNA small subunit methyltransferase G
DWB88_RS13235	COG0445	tRNA wobble uridine modification
DWB88_RS13240	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DWB88_RS13245	COG0594	ribonuclease P activity
DWB88_RS13295	COG4115	mRNA cleavage
DWB88_RS13405	COG4115	mRNA cleavage
DWB88_RS13540	COG1192	Involved in chromosome partitioning
DWB88_RS13620	COG0542	response to heat
DWB88_RS13735	COG1196	nuclear chromosome segregation
DWB88_RS13735	COG1674	ftsk spoiiie
DWB88_RS13760	COG4640	response to antibiotic
DWB88_RS13845	COG2337	Toxic component of a toxin-antitoxin (TA) module
DWB88_RS13920	COG4115	mRNA cleavage