locus-tag	class	description
FOC62_RS00005	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
FOC62_RS00045	COG1011	Hydrolase
FOC62_RS00060	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FOC62_RS00070	COG2801	Transposase and inactivated derivatives
FOC62_RS00075	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FOC62_RS00080	COG0693	protein deglycase activity
FOC62_RS00100	COG3527	Alpha-acetolactate decarboxylase
FOC62_RS00105	COG1620	l-lactate permease
FOC62_RS00110	COG0579	oxidoreductase
FOC62_RS00125	COG3226	Transcriptional regulator
FOC62_RS00150	COG0438	transferase activity, transferring glycosyl groups
FOC62_RS00170	COG2348	transferase activity, transferring amino-acyl groups
FOC62_RS00210	COG0492	ferredoxin-NADP+ reductase activity
FOC62_RS00215	COG1660	Displays ATPase and GTPase activities
FOC62_RS00220	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FOC62_RS00225	COG1481	regulation of sporulation
FOC62_RS00235	COG0740	serine-type endopeptidase activity
FOC62_RS00255	COG2390	Transcriptional regulator
FOC62_RS00265	COG0126	phosphoglycerate kinase activity
FOC62_RS00270	COG0149	triose-phosphate isomerase activity
FOC62_RS00275	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FOC62_RS00280	COG0148	phosphopyruvate hydratase activity
FOC62_RS00290	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FOC62_RS00295	COG1647	Serine aminopeptidase, S33
FOC62_RS00300	COG0557	exoribonuclease II activity
FOC62_RS00330	COG1309	transcriptional regulator
FOC62_RS00335	COG0656	L-ascorbic acid biosynthetic process
FOC62_RS00360	COG1278	Cold shock
FOC62_RS00385	COG4195	phage-related replication protein
FOC62_RS00420	COG0406	alpha-ribazole phosphatase activity
FOC62_RS00430	COG1764	response to oxidative stress
FOC62_RS00435	COG0710	3-dehydroquinate dehydratase activity
FOC62_RS00445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FOC62_RS00450	COG1393	Belongs to the ArsC family
FOC62_RS00455	COG0509	glycine decarboxylation via glycine cleavage system
FOC62_RS00460	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
FOC62_RS00470	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FOC62_RS00475	COG2011	ABC-type metal ion transport system permease component
FOC62_RS00480	COG1464	Belongs to the NlpA lipoprotein family
FOC62_RS00490	COG3237	CsbD-like
FOC62_RS00500	COG0396	ATPase activity
FOC62_RS00505	COG0719	Fe-S assembly protein
FOC62_RS00510	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FOC62_RS00515	COG0822	iron-sulfur transferase activity
FOC62_RS00520	COG0719	Fe-S assembly protein
FOC62_RS00525	COG1253	flavin adenine dinucleotide binding
FOC62_RS00530	COG2070	2-Nitropropane dioxygenase
FOC62_RS00535	COG1801	Protein of unknown function DUF72
FOC62_RS00540	COG0730	response to heat
FOC62_RS00545	COG0737	Belongs to the 5'-nucleotidase family
FOC62_RS00550	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FOC62_RS00555	COG4470	Protein conserved in bacteria
FOC62_RS00565	COG2445	Protein of unknown function DUF86
FOC62_RS00585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FOC62_RS00590	COG1696	Membrane protein involved in D-alanine export
FOC62_RS00600	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
FOC62_RS00610	COG0583	DNA-binding transcription factor activity
FOC62_RS00615	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FOC62_RS00620	COG4837	Protein of unknown function (DUF1462)
FOC62_RS00625	COG1252	NADH dehydrogenase
FOC62_RS00630	COG4844	belongs to the
FOC62_RS00635	COG0316	Belongs to the HesB IscA family
FOC62_RS00645	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FOC62_RS00650	COG2056	Na+-H+ antiporter family
FOC62_RS00655	COG2050	protein possibly involved in aromatic compounds catabolism
FOC62_RS00675	COG2212	antiporter activity
FOC62_RS00685	COG0651	ATP synthesis coupled electron transport
FOC62_RS00690	COG1006	Multisubunit Na H antiporter MnhC subunit
FOC62_RS00695	COG2111	Na H antiporter
FOC62_RS00700	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FOC62_RS00700	COG2111	Na H antiporter
FOC62_RS00715	COG1098	S1 RNA binding domain
FOC62_RS00720	COG1902	pentaerythritol trinitrate reductase activity
FOC62_RS00740	COG0584	glycerophosphoryl diester phosphodiesterase
FOC62_RS00745	COG0584	glycerophosphoryl diester phosphodiesterase
FOC62_RS00750	COG0165	Argininosuccinate lyase
FOC62_RS00755	COG0137	argininosuccinate synthase activity
FOC62_RS00765	COG0398	Pfam SNARE associated Golgi protein
FOC62_RS00785	COG1074	ATP-dependent DNA helicase activity
FOC62_RS00800	COG0446	pyridine nucleotide-disulphide oxidoreductase
FOC62_RS00805	COG0561	phosphatase activity
FOC62_RS00820	COG0542	response to heat
FOC62_RS00830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FOC62_RS00845	COG0601	transmembrane transport
FOC62_RS00850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FOC62_RS00855	COG0444	Belongs to the ABC transporter superfamily
FOC62_RS00860	COG4608	Belongs to the ABC transporter superfamily
FOC62_RS00865	COG4166	transmembrane transport
FOC62_RS00870	COG0180	Tryptophanyl-tRNA synthetase
FOC62_RS00875	COG1393	Belongs to the ArsC family
FOC62_RS00880	COG4862	establishment of competence for transformation
FOC62_RS00890	COG1164	Oligoendopeptidase f
FOC62_RS00900	COG2346	COG2346, Truncated hemoglobins
FOC62_RS00915	COG2357	RelA SpoT domain protein
FOC62_RS00920	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FOC62_RS00925	COG0564	pseudouridine synthase activity
FOC62_RS00930	COG2239	Acts as a magnesium transporter
FOC62_RS00935	COG0475	glutathione-regulated potassium exporter activity
FOC62_RS00935	COG0569	domain protein
FOC62_RS00945	COG0628	permease
FOC62_RS00950	COG1115	amino acid carrier protein
FOC62_RS00955	COG2382	esterase
FOC62_RS00960	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FOC62_RS00965	COG2814	Major facilitator Superfamily
FOC62_RS00970	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FOC62_RS00975	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FOC62_RS00985	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FOC62_RS00990	COG0861	Integral membrane protein TerC family
FOC62_RS00995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FOC62_RS01000	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FOC62_RS01015	COG4873	Protein conserved in bacteria
FOC62_RS01050	COG2314	TM2 domain
FOC62_RS01060	COG1575	Belongs to the MenA family. Type 1 subfamily
FOC62_RS01065	COG1169	isochorismate synthase
FOC62_RS01070	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FOC62_RS01080	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FOC62_RS01085	COG0436	Aminotransferase
FOC62_RS01090	COG3594	Acyltransferase
FOC62_RS01115	COG1316	TRANSCRIPTIONal
FOC62_RS01130	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
FOC62_RS01145	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FOC62_RS01155	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FOC62_RS01155	COG1017	nitric oxide dioxygenase activity
FOC62_RS01160	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FOC62_RS01165	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FOC62_RS01175	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FOC62_RS01180	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FOC62_RS01185	COG0047	phosphoribosylformylglycinamidine synthase activity
FOC62_RS01200	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FOC62_RS01210	COG0138	bifunctional purine biosynthesis protein purh
FOC62_RS01215	COG0151	Belongs to the GarS family
FOC62_RS01220	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FOC62_RS01225	COG4172	Belongs to the ABC transporter superfamily
FOC62_RS01240	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FOC62_RS01250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FOC62_RS01255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FOC62_RS01265	COG1271	oxidase subunit
FOC62_RS01270	COG1294	oxidase, subunit
FOC62_RS01275	COG0569	domain protein
FOC62_RS01280	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FOC62_RS01290	COG0242	peptide deformylase activity
FOC62_RS01310	COG0508	dehydrogenase complex catalyzes the overall conversion of
FOC62_RS01320	COG4476	Belongs to the UPF0223 family
FOC62_RS01335	COG1176	ABC-type spermidine putrescine transport system, permease component I
FOC62_RS01365	COG4493	Belongs to the UPF0637 family
FOC62_RS01370	COG0483	inositol monophosphate 1-phosphatase activity
FOC62_RS01385	COG4896	Protein conserved in bacteria
FOC62_RS01390	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FOC62_RS01395	COG4838	Belongs to the UPF0358 family
FOC62_RS01400	COG0772	Belongs to the SEDS family
FOC62_RS01410	COG1612	heme a metabolic process
FOC62_RS01415	COG0109	protoheme IX farnesyltransferase activity
FOC62_RS01430	COG3679	Belongs to the UPF0342 family
FOC62_RS01435	COG0584	glycerophosphoryl diester phosphodiesterase
FOC62_RS01450	COG0742	ribosomal rna small subunit methyltransferase
FOC62_RS01455	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FOC62_RS01470	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FOC62_RS01475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FOC62_RS01480	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FOC62_RS01485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FOC62_RS01485	COG0072	phenylalanine-tRNA ligase activity
FOC62_RS01490	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FOC62_RS01495	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
FOC62_RS01505	COG1796	DNA polymerase
FOC62_RS01505	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
FOC62_RS01510	COG1193	negative regulation of DNA recombination
FOC62_RS01515	COG3118	belongs to the thioredoxin family
FOC62_RS01520	COG0322	excinuclease ABC activity
FOC62_RS01525	COG2009	succinate dehydrogenase
FOC62_RS01530	COG1053	succinate dehydrogenase
FOC62_RS01535	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FOC62_RS01540	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FOC62_RS01545	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FOC62_RS01580	COG1011	Hydrolase
FOC62_RS01590	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
FOC62_RS01600	COG0275	rRNA processing
FOC62_RS01605	COG4839	cell division protein FtsL
FOC62_RS01615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FOC62_RS01625	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
FOC62_RS01630	COG0849	cell division
FOC62_RS01635	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FOC62_RS01645	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FOC62_RS01650	COG1799	cell septum assembly
FOC62_RS01655	COG0762	integral membrane protein
FOC62_RS01665	COG3599	regulation of cell shape
FOC62_RS01670	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FOC62_RS01680	COG1388	LysM domain
FOC62_RS01680	COG3942	CHAP domain
FOC62_RS01685	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FOC62_RS01690	COG0564	pseudouridine synthase activity
FOC62_RS01700	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FOC62_RS01705	COG2233	PERMEase
FOC62_RS01710	COG0540	Belongs to the ATCase OTCase family
FOC62_RS01715	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FOC62_RS01720	COG0505	Belongs to the CarA family
FOC62_RS01725	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FOC62_RS01730	COG0284	orotidine-5'-phosphate decarboxylase activity
FOC62_RS01735	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FOC62_RS01755	COG0194	GDP metabolic process
FOC62_RS01760	COG1758	RNA polymerase activity
FOC62_RS01765	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FOC62_RS01770	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FOC62_RS01785	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FOC62_RS01790	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FOC62_RS01790	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FOC62_RS01795	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FOC62_RS01800	COG0631	protein serine/threonine phosphatase activity
FOC62_RS01810	COG1162	GTPase activity
FOC62_RS01815	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FOC62_RS01825	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FOC62_RS01830	COG1302	Protein conserved in bacteria
FOC62_RS01835	COG1461	Dihydroxyacetone kinase
FOC62_RS01840	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FOC62_RS01845	COG1349	DNA-binding transcription factor activity
FOC62_RS01850	COG0416	fatty acid biosynthetic process
FOC62_RS01865	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FOC62_RS01870	COG0571	ribonuclease III activity
FOC62_RS01875	COG1196	nuclear chromosome segregation
FOC62_RS01880	COG0552	protein localization to endoplasmic reticulum
FOC62_RS01885	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
FOC62_RS01890	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FOC62_RS01895	COG0228	four-way junction DNA binding
FOC62_RS01900	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FOC62_RS01905	COG0336	Belongs to the RNA methyltransferase TrmD family
FOC62_RS01920	COG4485	Bacterial membrane protein, YfhO
FOC62_RS01930	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FOC62_RS01935	COG0045	succinate-CoA ligase (ADP-forming) activity
FOC62_RS01940	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FOC62_RS01945	COG0758	DNA mediated transformation
FOC62_RS01950	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FOC62_RS01955	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
FOC62_RS01960	COG4974	Belongs to the 'phage' integrase family
FOC62_RS01965	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FOC62_RS01980	COG0052	Belongs to the universal ribosomal protein uS2 family
FOC62_RS01985	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FOC62_RS01990	COG0528	UMP kinase activity
FOC62_RS01995	COG0233	cytoplasmic translational termination
FOC62_RS02000	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FOC62_RS02005	COG4589	Belongs to the CDS family
FOC62_RS02015	COG0442	prolyl-tRNA aminoacylation
FOC62_RS02020	COG2176	DNA-directed DNA polymerase activity
FOC62_RS02025	COG0779	Required for maturation of 30S ribosomal subunits
FOC62_RS02030	COG0195	Participates in both transcription termination and antitermination
FOC62_RS02035	COG2740	Nucleic-acid-binding protein implicated in transcription termination
FOC62_RS02040	COG1358	cellular component organization or biogenesis
FOC62_RS02045	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FOC62_RS02050	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FOC62_RS02055	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FOC62_RS02060	COG0196	riboflavin kinase activity
FOC62_RS02065	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FOC62_RS02070	COG1185	polyribonucleotide nucleotidyltransferase activity
FOC62_RS02080	COG1674	ftsk spoiiie
FOC62_RS02085	COG2188	Transcriptional regulator
FOC62_RS02090	COG0612	Peptidase, M16
FOC62_RS02095	COG0612	Peptidase, M16
FOC62_RS02100	COG0300	oxidoreductase activity
FOC62_RS02110	COG1426	Protein conserved in bacteria
FOC62_RS02125	COG1546	Belongs to the CinA family
FOC62_RS02125	COG1058	Belongs to the CinA family
FOC62_RS02130	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FOC62_RS02135	COG1418	mRNA catabolic process
FOC62_RS02145	COG1692	metallophosphoesterase
FOC62_RS02150	COG0674	pyruvate-flavodoxin oxidoreductase activity
FOC62_RS02150	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FOC62_RS02155	COG1013	pyruvate-flavodoxin oxidoreductase activity
FOC62_RS02160	COG4195	phage-related replication protein
FOC62_RS02170	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FOC62_RS02175	COG4550	Control of competence regulator ComK, YlbF/YmcA
FOC62_RS02185	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FOC62_RS02190	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FOC62_RS02195	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
FOC62_RS02200	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FOC62_RS02210	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FOC62_RS02220	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FOC62_RS02225	COG1923	regulation of RNA biosynthetic process
FOC62_RS02230	COG0386	Belongs to the glutathione peroxidase family
FOC62_RS02235	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FOC62_RS02240	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
FOC62_RS02245	COG0789	Transcriptional regulator
FOC62_RS02310	COG1131	(ABC) transporter
FOC62_RS02320	COG4585	Histidine kinase
FOC62_RS02325	COG2197	response regulator
FOC62_RS02340	COG1525	nuclease
FOC62_RS02355	COG0527	aspartate kinase activity
FOC62_RS02360	COG0460	homoserine dehydrogenase
FOC62_RS02365	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FOC62_RS02370	COG0083	homoserine kinase activity
FOC62_RS02385	COG0833	amino acid
FOC62_RS02400	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FOC62_RS02425	COG4224	UPF0291 protein
FOC62_RS02435	COG3763	UPF0154 protein
FOC62_RS02445	COG4846	Membrane protein involved in cytochrome C biogenesis
FOC62_RS02460	COG1970	mechanosensitive ion channel activity
FOC62_RS02465	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FOC62_RS02470	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FOC62_RS02475	COG0824	Thioesterase
FOC62_RS02490	COG0187	DNA topoisomerase II activity
FOC62_RS02495	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FOC62_RS02500	COG1115	amino acid carrier protein
FOC62_RS02505	COG3711	transcriptional antiterminator
FOC62_RS02510	COG0628	permease
FOC62_RS02515	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
FOC62_RS02515	COG0392	lysyltransferase activity
FOC62_RS02530	COG1942	4-Oxalocrotonate Tautomerase
FOC62_RS02535	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FOC62_RS02540	COG0287	Prephenate dehydrogenase
FOC62_RS02545	COG1363	Peptidase, m42
FOC62_RS02550	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FOC62_RS02555	COG0512	Glutamine amidotransferase of anthranilate synthase
FOC62_RS02565	COG0134	indole-3-glycerol-phosphate synthase activity
FOC62_RS02585	COG2348	transferase activity, transferring amino-acyl groups
FOC62_RS02590	COG2348	transferase activity, transferring amino-acyl groups
FOC62_RS02595	COG0561	phosphatase activity
FOC62_RS02600	COG4607	ABC-type enterochelin transport system periplasmic component
FOC62_RS02640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FOC62_RS02645	COG0581	inorganic phosphate transmembrane transporter activity
FOC62_RS02650	COG0573	inorganic phosphate transmembrane transporter activity
FOC62_RS02655	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FOC62_RS02660	COG2996	Protein conserved in bacteria
FOC62_RS02665	COG0488	(ABC) transporter
FOC62_RS02670	COG0527	aspartate kinase activity
FOC62_RS02675	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FOC62_RS02680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FOC62_RS02685	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FOC62_RS02695	COG1473	amidohydrolase
FOC62_RS02710	COG1278	Cold shock
FOC62_RS02720	COG1254	Belongs to the acylphosphatase family
FOC62_RS02730	COG3853	Toxic anion resistance protein (TelA)
FOC62_RS02735	COG1114	Component of the transport system for branched-chain amino acids
FOC62_RS02740	COG4548	von Willebrand factor, type A
FOC62_RS02745	COG0714	Associated with various cellular activities
FOC62_RS02770	COG0567	Dehydrogenase, E1 component
FOC62_RS02775	COG5002	protein histidine kinase activity
FOC62_RS02780	COG0745	RESPONSE REGULATOR receiver
FOC62_RS02785	COG0671	phosphoesterase, PA-phosphatase related
FOC62_RS02790	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FOC62_RS02800	COG0793	Belongs to the peptidase S41A family
FOC62_RS02810	COG2190	(PTS) system
FOC62_RS02815	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FOC62_RS02845	COG1413	lyase activity
FOC62_RS02850	COG1413	lyase activity
FOC62_RS02860	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
FOC62_RS02875	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FOC62_RS02880	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
FOC62_RS02890	COG0116	Belongs to the methyltransferase superfamily
FOC62_RS02900	COG3599	regulation of cell shape
FOC62_RS02915	COG3331	DNA recombination
FOC62_RS02920	COG4499	WXG100 protein secretion system (Wss), protein YukC
FOC62_RS02920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FOC62_RS02930	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FOC62_RS02935	COG3935	DnaD domain protein
FOC62_RS02940	COG0017	Asparaginyl-tRNA synthetase
FOC62_RS02945	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FOC62_RS02945	COG1199	ATP-dependent helicase activity
FOC62_RS02955	COG0617	tRNA 3'-terminal CCA addition
FOC62_RS02960	COG0438	transferase activity, transferring glycosyl groups
FOC62_RS02965	COG1694	Mazg nucleotide pyrophosphohydrolase
FOC62_RS02970	COG2738	Putative neutral zinc metallopeptidase
FOC62_RS02975	COG4347	Protein of unknown function (DUF1405)
FOC62_RS02980	COG5582	Belongs to the UPF0302 family
FOC62_RS02990	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FOC62_RS02995	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FOC62_RS03000	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FOC62_RS03015	COG2226	methyltransferase
FOC62_RS03030	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FOC62_RS03035	COG1160	GTP binding
FOC62_RS03040	COG0539	negative regulation of cytoplasmic translation
FOC62_RS03055	COG0492	ferredoxin-NADP+ reductase activity
FOC62_RS03065	COG0514	ATP-dependent DNA helicase (RecQ)
FOC62_RS03075	COG1141	Ferredoxin
FOC62_RS03090	COG0745	RESPONSE REGULATOR receiver
FOC62_RS03095	COG1187	pseudouridine synthase activity
FOC62_RS03100	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FOC62_RS03105	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FOC62_RS03115	COG4974	Belongs to the 'phage' integrase family
FOC62_RS03120	COG0735	belongs to the Fur family
FOC62_RS03125	COG0494	nUDIX hydrolase
FOC62_RS03130	COG0667	Aldo Keto reductase
FOC62_RS03135	COG1028	Short-chain dehydrogenase reductase Sdr
FOC62_RS03140	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FOC62_RS03150	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FOC62_RS03160	COG0366	Alpha amylase catalytic
FOC62_RS03165	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FOC62_RS03170	COG2195	Cleaves the N-terminal amino acid of tripeptides
FOC62_RS03175	COG4129	membrane
FOC62_RS03185	COG0508	dehydrogenase complex catalyzes the overall conversion of
FOC62_RS03190	COG0022	dehydrogenase e1 component
FOC62_RS03195	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FOC62_RS03200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FOC62_RS03205	COG0497	DNA recombination
FOC62_RS03210	COG1438	arginine binding
FOC62_RS03215	COG0142	geranyltranstransferase activity
FOC62_RS03220	COG1722	exodeoxyribonuclease VII activity
FOC62_RS03230	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FOC62_RS03235	COG1302	Protein conserved in bacteria
FOC62_RS03240	COG0439	Biotin carboxylase
FOC62_RS03245	COG0511	ligase activity, forming carbon-carbon bonds
FOC62_RS03250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FOC62_RS03255	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FOC62_RS03260	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FOC62_RS03265	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FOC62_RS03270	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FOC62_RS03275	COG0006	proline dipeptidase activity
FOC62_RS03290	COG0095	Lipoate-protein ligase
FOC62_RS03295	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FOC62_RS03305	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FOC62_RS03310	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FOC62_RS03315	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FOC62_RS03330	COG4537	Required for transformation and DNA binding
FOC62_RS03335	COG1459	type II secretion system
FOC62_RS03340	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FOC62_RS03345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FOC62_RS03350	COG0011	TIGRFAM Protein of
FOC62_RS03355	COG1940	carbohydrate kinase activity
FOC62_RS03360	COG4483	Protein conserved in bacteria
FOC62_RS03370	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FOC62_RS03375	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FOC62_RS03395	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FOC62_RS03400	COG1121	(ABC) transporter
FOC62_RS03405	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FOC62_RS03410	COG0513	Belongs to the DEAD box helicase family
FOC62_RS03415	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FOC62_RS03420	COG2384	SAM-dependent methyltransferase
FOC62_RS03425	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FOC62_RS03435	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FOC62_RS03440	COG0517	IMP dehydrogenase activity
FOC62_RS03445	COG0423	glycine-tRNA ligase activity
FOC62_RS03450	COG1381	Involved in DNA repair and RecF pathway recombination
FOC62_RS03455	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FOC62_RS03465	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FOC62_RS03475	COG1702	phosphate starvation-inducible protein PhoH
FOC62_RS03485	COG4864	UPF0365 protein
FOC62_RS03490	COG1030	water channel activity
FOC62_RS03500	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FOC62_RS03505	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FOC62_RS03510	COG2264	protein methyltransferase activity
FOC62_RS03515	COG0484	heat shock protein binding
FOC62_RS03520	COG0443	Heat shock 70 kDa protein
FOC62_RS03525	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FOC62_RS03535	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FOC62_RS03540	COG0481	GTPase activity
FOC62_RS03545	COG0268	Binds directly to 16S ribosomal RNA
FOC62_RS03550	COG1466	dna polymerase III delta subunit
FOC62_RS03560	COG2131	deaminase
FOC62_RS03570	COG2226	methyltransferase
FOC62_RS03575	COG0799	negative regulation of ribosome biogenesis
FOC62_RS03580	COG1713	HD superfamily hydrolase involved in NAD metabolism
FOC62_RS03585	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FOC62_RS03590	COG1534	Rna-binding protein
FOC62_RS03595	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FOC62_RS03600	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
FOC62_RS03605	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
FOC62_RS03610	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FOC62_RS03615	COG1914	H( )-stimulated, divalent metal cation uptake system
FOC62_RS03625	COG0439	Biotin carboxylase
FOC62_RS03630	COG0511	ligase activity, forming carbon-carbon bonds
FOC62_RS03635	COG1984	allophanate hydrolase subunit 2
FOC62_RS03640	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FOC62_RS03645	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FOC62_RS03650	COG0572	uridine kinase
FOC62_RS03665	COG4122	O-methyltransferase activity
FOC62_RS03670	COG3906	Belongs to the UPF0473 family
FOC62_RS03675	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FOC62_RS03680	COG4472	Bacterial protein of unknown function (DUF965)
FOC62_RS03690	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FOC62_RS03700	COG0482	sulfurtransferase activity
FOC62_RS03705	COG1104	cysteine desulfurase activity
FOC62_RS03710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FOC62_RS03720	COG1959	2 iron, 2 sulfur cluster binding
FOC62_RS03725	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FOC62_RS03730	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
FOC62_RS03740	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FOC62_RS03750	COG0860	N-Acetylmuramoyl-L-alanine amidase
FOC62_RS03760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FOC62_RS03770	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FOC62_RS03770	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FOC62_RS03775	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FOC62_RS03775	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FOC62_RS03780	COG1862	Preprotein translocase
FOC62_RS03790	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FOC62_RS03800	COG0632	four-way junction helicase activity
FOC62_RS03805	COG4492	Belongs to the UPF0735 family
FOC62_RS03810	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FOC62_RS03815	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FOC62_RS03820	COG2868	ribosomal protein
FOC62_RS03825	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FOC62_RS03860	COG2003	Belongs to the UPF0758 family
FOC62_RS03870	COG0285	dihydrofolate synthase activity
FOC62_RS03875	COG0525	valine-tRNA ligase activity
FOC62_RS03880	COG2818	Glycosylase
FOC62_RS03890	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FOC62_RS03895	COG0113	porphobilinogen synthase activity
FOC62_RS03905	COG0181	hydroxymethylbilane synthase activity
FOC62_RS03910	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FOC62_RS03915	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FOC62_RS03920	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FOC62_RS03925	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FOC62_RS03930	COG0544	peptidyl-prolyl cis-trans isomerase activity
FOC62_RS03940	COG4112	unkown
FOC62_RS03945	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FOC62_RS03950	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FOC62_RS03955	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FOC62_RS03960	COG0833	amino acid
FOC62_RS03970	COG1484	DNA-dependent DNA replication
FOC62_RS03975	COG3611	Membrane attachment protein
FOC62_RS03980	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FOC62_RS03985	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FOC62_RS04000	COG2801	Transposase and inactivated derivatives
FOC62_RS04010	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FOC62_RS04015	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FOC62_RS04015	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FOC62_RS04020	COG5002	protein histidine kinase activity
FOC62_RS04025	COG0745	RESPONSE REGULATOR receiver
FOC62_RS04030	COG0538	isocitrate dehydrogenase activity
FOC62_RS04035	COG0372	Belongs to the citrate synthase family
FOC62_RS04040	COG1113	amino acid transport
FOC62_RS04045	COG0469	pyruvate kinase activity
FOC62_RS04050	COG0205	6-phosphofructokinase activity
FOC62_RS04060	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FOC62_RS04065	COG0281	malic enzyme
FOC62_RS04070	COG0587	DNA-directed DNA polymerase activity
FOC62_RS04075	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FOC62_RS04080	COG4109	DRTGG domain
FOC62_RS04090	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FOC62_RS04095	COG0006	proline dipeptidase activity
FOC62_RS04100	COG0686	Belongs to the AlaDH PNT family
FOC62_RS04105	COG0589	response to stress
FOC62_RS04110	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FOC62_RS04115	COG0827	DNA restriction-modification system
FOC62_RS04120	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FOC62_RS04130	COG0301	tRNA thio-modification
FOC62_RS04135	COG1104	cysteine desulfurase activity
FOC62_RS04140	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
FOC62_RS04145	COG1956	GAF domain-containing protein
FOC62_RS04150	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FOC62_RS04155	COG0584	glycerophosphoryl diester phosphodiesterase
FOC62_RS04160	COG1764	response to oxidative stress
FOC62_RS04165	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
FOC62_RS04170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FOC62_RS04180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FOC62_RS04180	COG1263	PTS System
FOC62_RS04200	COG0204	Acyl-transferase
FOC62_RS04205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FOC62_RS04235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FOC62_RS04240	COG0454	-acetyltransferase
FOC62_RS04250	COG1609	Transcriptional regulator
FOC62_RS04255	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FOC62_RS04255	COG1605	Chorismate mutase
FOC62_RS04270	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FOC62_RS04275	COG1674	ftsk spoiiie
FOC62_RS04280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FOC62_RS04285	COG4848	Belongs to the UPF0354 family
FOC62_RS04290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FOC62_RS04295	COG1363	Peptidase, m42
FOC62_RS04305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FOC62_RS04310	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FOC62_RS04315	COG0510	thiamine kinase activity
FOC62_RS04320	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FOC62_RS04325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FOC62_RS04335	COG1187	pseudouridine synthase activity
FOC62_RS04340	COG2244	polysaccharide biosynthetic process
FOC62_RS04345	COG2081	HI0933 family
FOC62_RS04360	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FOC62_RS04365	COG0495	leucyl-tRNA aminoacylation
FOC62_RS04370	COG2814	Major facilitator Superfamily
FOC62_RS04375	COG1242	4 iron, 4 sulfur cluster binding
FOC62_RS04380	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
FOC62_RS04390	COG2267	carboxylic ester hydrolase activity
FOC62_RS04395	COG0506	proline dehydrogenase activity
FOC62_RS04400	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FOC62_RS04405	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FOC62_RS04405	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FOC62_RS04410	COG0307	riboflavin synthase, alpha
FOC62_RS04415	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FOC62_RS04415	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FOC62_RS04450	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FOC62_RS04460	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FOC62_RS04465	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FOC62_RS04470	COG0656	L-ascorbic acid biosynthetic process
FOC62_RS04480	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FOC62_RS04490	COG1506	peptidase
FOC62_RS04495	COG0494	nUDIX hydrolase
FOC62_RS04510	COG0318	PFAM AMP-dependent synthetase and ligase
FOC62_RS04560	COG3545	Serine hydrolase
FOC62_RS04580	COG2329	Antibiotic biosynthesis monooxygenase
FOC62_RS04585	COG4473	ABC transporter
FOC62_RS04590	COG1131	(ABC) transporter
FOC62_RS04595	COG0537	adenosine 5'-monophosphoramidase activity
FOC62_RS04610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FOC62_RS04620	COG3481	metal-dependent phosphohydrolase, HD sub domain
FOC62_RS04630	COG0420	3'-5' exonuclease activity
FOC62_RS04635	COG3679	Belongs to the UPF0342 family
FOC62_RS04640	COG4399	Belongs to the UPF0754 family
FOC62_RS04650	COG2197	response regulator
FOC62_RS04655	COG4585	Histidine kinase
FOC62_RS04655	COG2203	Gaf domain
FOC62_RS04660	COG0564	pseudouridine synthase activity
FOC62_RS04680	COG0363	glucosamine-6-phosphate deaminase activity
FOC62_RS04690	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FOC62_RS04695	COG1126	abc transporter atp-binding protein
FOC62_RS04700	COG0765	amino acid transport
FOC62_RS04880	COG0735	belongs to the Fur family
FOC62_RS04885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FOC62_RS04890	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FOC62_RS04895	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FOC62_RS04900	COG4129	membrane
FOC62_RS04910	COG3557	Belongs to the UPF0374 family
FOC62_RS04915	COG1194	a g-specific adenine glycosylase
FOC62_RS04920	COG1988	membrane-bound metal-dependent
FOC62_RS04930	COG1388	LysM domain
FOC62_RS04930	COG1134	teichoic acid transport
FOC62_RS04945	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FOC62_RS04950	COG0693	protein deglycase activity
FOC62_RS04965	COG5632	N-Acetylmuramoyl-L-alanine amidase
FOC62_RS04965	COG1388	LysM domain
FOC62_RS05055	COG0740	serine-type endopeptidase activity
FOC62_RS05125	COG1525	nuclease
FOC62_RS05165	COG0556	nucleotide-excision repair
FOC62_RS05215	COG3620	sequence-specific DNA binding
FOC62_RS05250	COG4974	Belongs to the 'phage' integrase family
FOC62_RS05255	COG0535	radical SAM domain protein
FOC62_RS05265	COG2309	aminopeptidase activity
FOC62_RS05270	COG4840	Belongs to the UPF0435 family
FOC62_RS05275	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FOC62_RS05285	COG1295	ribonuclease BN
FOC62_RS05290	COG2197	response regulator
FOC62_RS05310	COG0024	Methionine aminopeptidase
FOC62_RS05315	COG4129	membrane
FOC62_RS05330	COG1528	Iron-storage protein
FOC62_RS05350	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FOC62_RS05355	COG1597	lipid kinase activity
FOC62_RS05360	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FOC62_RS05365	COG0154	amidase activity
FOC62_RS05385	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FOC62_RS05390	COG0210	DNA helicase
FOC62_RS05395	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
FOC62_RS05400	COG4496	protein, YerC YecD
FOC62_RS05405	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FOC62_RS05415	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
FOC62_RS05420	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FOC62_RS05425	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FOC62_RS05435	COG0077	Prephenate dehydratase
FOC62_RS05445	COG1335	isochorismatase
FOC62_RS05450	COG1227	inorganic diphosphatase activity
FOC62_RS05455	COG1012	belongs to the aldehyde dehydrogenase family
FOC62_RS05460	COG2706	6-phosphogluconolactonase activity
FOC62_RS05465	COG2226	methyltransferase
FOC62_RS05475	COG0640	Transcriptional regulator
FOC62_RS05540	COG1131	(ABC) transporter
FOC62_RS05555	COG1725	Transcriptional regulator
FOC62_RS05580	COG0459	protein refolding
FOC62_RS05585	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FOC62_RS05630	COG3290	protein histidine kinase activity
FOC62_RS05640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FOC62_RS05645	COG1621	beta-fructofuranosidase activity
FOC62_RS05650	COG1609	Transcriptional regulator
FOC62_RS05655	COG0425	Belongs to the sulfur carrier protein TusA family
FOC62_RS05660	COG2391	methyltransferase activity
FOC62_RS05675	COG0488	(ABC) transporter
FOC62_RS05680	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FOC62_RS05685	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FOC62_RS05690	COG0456	acetyltransferase
FOC62_RS05695	COG1214	PFAM Peptidase M22, glycoprotease
FOC62_RS05700	COG0802	atpase or kinase
FOC62_RS05710	COG0028	Belongs to the TPP enzyme family
FOC62_RS05730	COG0473	3-isopropylmalate dehydrogenase activity
FOC62_RS05735	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FOC62_RS05780	COG2183	response to ionizing radiation
FOC62_RS05785	COG1191	sigma factor activity
FOC62_RS05800	COG2208	phosphoserine phosphatase activity
FOC62_RS05805	COG2337	Toxic component of a toxin-antitoxin (TA) module
FOC62_RS05815	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FOC62_RS05820	COG0736	holo-[acyl-carrier-protein] synthase activity
FOC62_RS05825	COG3402	PFAM membrane-flanked domain
FOC62_RS05830	COG3428	Bacterial PH domain
FOC62_RS05840	COG0513	Belongs to the DEAD box helicase family
FOC62_RS05845	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FOC62_RS05850	COG1181	Belongs to the D-alanine--D-alanine ligase family
FOC62_RS05855	COG0772	Belongs to the SEDS family
FOC62_RS05870	COG1937	Protein conserved in bacteria
FOC62_RS05875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FOC62_RS05880	COG1418	mRNA catabolic process
FOC62_RS05885	COG0706	membrane insertase activity
FOC62_RS05895	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
FOC62_RS05905	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FOC62_RS05915	COG0629	single-stranded DNA binding
FOC62_RS05925	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FOC62_RS05940	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FOC62_RS05945	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FOC62_RS05950	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FOC62_RS05960	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FOC62_RS05985	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FOC62_RS05990	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FOC62_RS06000	COG4475	Protein of unknown function (DUF436)
FOC62_RS06005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FOC62_RS06010	COG0009	L-threonylcarbamoyladenylate synthase
FOC62_RS06015	COG2890	protein-(glutamine-N5) methyltransferase activity
FOC62_RS06025	COG1435	thymidine kinase activity
FOC62_RS06030	COG0254	rRNA binding
FOC62_RS06035	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FOC62_RS06040	COG1012	belongs to the aldehyde dehydrogenase family
FOC62_RS06050	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FOC62_RS06055	COG0191	fructose-bisphosphate aldolase activity
FOC62_RS06065	COG0504	CTP synthase activity
FOC62_RS06080	COG5146	pantothenate kinase activity
FOC62_RS06100	COG1854	S-ribosylhomocysteine lyase activity
FOC62_RS06110	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
FOC62_RS06115	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
FOC62_RS06120	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FOC62_RS06130	COG0783	Belongs to the Dps family
FOC62_RS06150	COG1482	cell wall glycoprotein biosynthetic process
FOC62_RS06155	COG0702	epimerase
FOC62_RS06160	COG0640	Transcriptional regulator
FOC62_RS06180	COG0561	phosphatase activity
FOC62_RS06195	COG3711	transcriptional antiterminator
FOC62_RS06220	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
FOC62_RS06275	COG0489	protein tyrosine kinase activity
FOC62_RS06280	COG2814	Major facilitator Superfamily
FOC62_RS06295	COG1272	protein, Hemolysin III
FOC62_RS06300	COG4284	Utp--glucose-1-phosphate uridylyltransferase
FOC62_RS06305	COG1988	membrane-bound metal-dependent
FOC62_RS06315	COG2329	Antibiotic biosynthesis monooxygenase
FOC62_RS06325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOC62_RS06330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOC62_RS06335	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
FOC62_RS06340	COG3457	Alanine racemase
FOC62_RS06345	COG4264	IucA IucC family
FOC62_RS06350	COG2814	Major facilitator Superfamily
FOC62_RS06355	COG4264	IucA IucC family
FOC62_RS06360	COG1302	Protein conserved in bacteria
FOC62_RS06375	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FOC62_RS06380	COG0604	alcohol dehydrogenase
FOC62_RS06385	COG2130	NADP-dependent
FOC62_RS06390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FOC62_RS06430	COG0698	ribose 5-phosphate isomerase
FOC62_RS06445	COG0789	Transcriptional regulator
FOC62_RS06460	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FOC62_RS06475	COG1122	ATPase activity
FOC62_RS06490	COG0202	RNA polymerase activity
FOC62_RS06495	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FOC62_RS06500	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FOC62_RS06510	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FOC62_RS06515	COG0563	adenylate kinase activity
FOC62_RS06520	COG0201	protein transport
FOC62_RS06530	COG1841	ribosomal large subunit assembly
FOC62_RS06535	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FOC62_RS06540	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FOC62_RS06545	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FOC62_RS06550	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FOC62_RS06555	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FOC62_RS06565	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FOC62_RS06570	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FOC62_RS06575	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FOC62_RS06585	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FOC62_RS06590	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FOC62_RS06595	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FOC62_RS06600	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FOC62_RS06605	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FOC62_RS06610	COG0089	rRNA binding
FOC62_RS06615	COG0088	Forms part of the polypeptide exit tunnel
FOC62_RS06620	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FOC62_RS06640	COG2801	Transposase and inactivated derivatives
FOC62_RS06645	COG2252	PERMEase
FOC62_RS06660	COG4975	Glucose uptake
FOC62_RS06685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FOC62_RS06690	COG2348	transferase activity, transferring amino-acyl groups
FOC62_RS06705	COG2814	Major facilitator Superfamily
FOC62_RS06735	COG1763	Mo-molybdopterin cofactor biosynthetic process
FOC62_RS06745	COG0315	cyclic pyranopterin monophosphate synthase activity
FOC62_RS06750	COG0521	Mo-molybdopterin cofactor biosynthetic process
FOC62_RS06755	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FOC62_RS06765	COG4149	molybdate abc transporter
FOC62_RS06770	COG0725	ABC transporter, periplasmic molybdate-binding protein
FOC62_RS06775	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FOC62_RS06785	COG1268	BioY protein
FOC62_RS06795	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FOC62_RS06800	COG1960	acyl-CoA dehydrogenase activity
FOC62_RS06805	COG1126	abc transporter atp-binding protein
FOC62_RS06810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FOC62_RS06815	COG0765	amino acid transport
FOC62_RS06820	COG0765	amino acid transport
FOC62_RS06825	COG4413	Urea transporter
FOC62_RS06830	COG0831	urea catabolic process
FOC62_RS06840	COG0804	urea catabolic process
FOC62_RS06845	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
FOC62_RS06850	COG0830	nickel cation binding
FOC62_RS06860	COG0829	nickel cation binding
FOC62_RS06875	COG1846	Transcriptional regulator
FOC62_RS06885	COG3942	CHAP domain
FOC62_RS06890	COG1757	Na H antiporter
FOC62_RS06905	COG3942	CHAP domain
FOC62_RS06910	COG2076	Multidrug Resistance protein
FOC62_RS06915	COG2076	Multidrug Resistance protein
FOC62_RS06920	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FOC62_RS06950	COG1316	TRANSCRIPTIONal
FOC62_RS06960	COG2378	regulation of single-species biofilm formation
FOC62_RS06965	COG1266	CAAX protease self-immunity
FOC62_RS06980	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FOC62_RS06985	COG1263	PTS System
FOC62_RS06985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FOC62_RS06995	COG1113	amino acid transport
FOC62_RS07015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FOC62_RS07020	COG0385	Bile acid
FOC62_RS07030	COG1263	PTS System
FOC62_RS07030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FOC62_RS07035	COG1737	Transcriptional regulator
FOC62_RS07055	COG1028	Short-chain dehydrogenase reductase Sdr
FOC62_RS07060	COG1473	amidohydrolase
FOC62_RS07075	COG0583	DNA-binding transcription factor activity
FOC62_RS07080	COG0010	Belongs to the arginase family
FOC62_RS07085	COG1266	CAAX protease self-immunity
FOC62_RS07090	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FOC62_RS07100	COG2017	converts alpha-aldose to the beta-anomer
FOC62_RS07105	COG1742	UPF0060 membrane protein
FOC62_RS07110	COG1668	transmembrane transport
FOC62_RS07115	COG4152	abc transporter atp-binding protein
FOC62_RS07120	COG1069	ribulokinase activity
FOC62_RS07130	COG3620	sequence-specific DNA binding
FOC62_RS07140	COG2094	Belongs to the DNA glycosylase MPG family
FOC62_RS07155	COG1695	Transcriptional regulator
FOC62_RS07160	COG0786	glutamate:sodium symporter activity
FOC62_RS07165	COG2801	Transposase and inactivated derivatives
FOC62_RS07175	COG1304	FMN binding
FOC62_RS07180	COG0598	Magnesium transport protein CorA
FOC62_RS07215	COG2814	Major facilitator Superfamily
FOC62_RS07220	COG1566	PFAM secretion protein HlyD family protein
FOC62_RS07230	COG2814	Major facilitator Superfamily
FOC62_RS07250	COG1136	(ABC) transporter
FOC62_RS07265	COG3850	Histidine kinase
FOC62_RS07265	COG5002	protein histidine kinase activity
FOC62_RS07280	COG0579	oxidoreductase
FOC62_RS07285	COG0438	transferase activity, transferring glycosyl groups
FOC62_RS07290	COG1620	l-lactate permease
FOC62_RS07295	COG0463	Glycosyl transferase, family 2
FOC62_RS07295	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FOC62_RS07305	COG0463	Glycosyl transferase, family 2
FOC62_RS07305	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FOC62_RS07315	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FOC62_RS07320	COG0805	protein transport
FOC62_RS07325	COG0672	)-iron permease
FOC62_RS07330	COG2837	iron assimilation
FOC62_RS07340	COG0604	alcohol dehydrogenase
FOC62_RS07345	COG0456	acetyltransferase
FOC62_RS07350	COG0492	ferredoxin-NADP+ reductase activity
FOC62_RS07385	COG1028	Short-chain dehydrogenase reductase Sdr
FOC62_RS07395	COG0583	DNA-binding transcription factor activity
FOC62_RS07425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FOC62_RS07425	COG1263	PTS System
FOC62_RS07455	COG1301	dicarboxylic acid transport
FOC62_RS07470	COG0778	Nitroreductase
FOC62_RS07485	COG2223	nitrite transmembrane transporter activity
FOC62_RS07505	COG2181	nitrate reductase activity
FOC62_RS07515	COG1140	nitrate reductase beta subunit
FOC62_RS07520	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
FOC62_RS07530	COG2146	nitrite reductase [NAD(P)H] activity
FOC62_RS07535	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FOC62_RS07545	COG0747	negative chemotaxis
FOC62_RS07550	COG0454	-acetyltransferase
FOC62_RS07565	COG0803	Belongs to the bacterial solute-binding protein 9 family
FOC62_RS07585	COG1126	abc transporter atp-binding protein
FOC62_RS07590	COG0765	amino acid transport
FOC62_RS07595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FOC62_RS07600	COG2814	Major facilitator Superfamily
FOC62_RS07610	COG0588	phosphoglycerate mutase activity
FOC62_RS07615	COG0741	lytic transglycosylase activity
FOC62_RS07620	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FOC62_RS07635	COG1929	Belongs to the glycerate kinase type-1 family
FOC62_RS07645	COG2814	Major facilitator Superfamily
FOC62_RS07665	COG1113	amino acid transport
FOC62_RS07675	COG0531	amino acid
FOC62_RS07685	COG0706	membrane insertase activity
FOC62_RS07705	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
FOC62_RS07715	COG1380	Effector of murein hydrolase LrgA
FOC62_RS07720	COG1346	cytolysis
FOC62_RS07725	COG1174	glycine betaine transport
FOC62_RS07750	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
FOC62_RS07755	COG0531	amino acid
FOC62_RS07760	COG2272	Belongs to the type-B carboxylesterase lipase family
FOC62_RS07765	COG2814	Major facilitator Superfamily
FOC62_RS07775	COG0745	RESPONSE REGULATOR receiver
FOC62_RS07780	COG2205	protein histidine kinase activity
FOC62_RS07785	COG0390	transport system, permease component
FOC62_RS07790	COG4619	ABC transporter
FOC62_RS07805	COG0069	glutamate synthase activity
FOC62_RS07825	COG4808	Protein conserved in bacteria
FOC62_RS07830	COG1363	Peptidase, m42
FOC62_RS07840	COG1028	Short-chain dehydrogenase reductase Sdr
FOC62_RS07845	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
FOC62_RS07855	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FOC62_RS07860	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FOC62_RS07880	COG0508	dehydrogenase complex catalyzes the overall conversion of
FOC62_RS07885	COG0022	dehydrogenase e1 component
FOC62_RS07890	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FOC62_RS07895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FOC62_RS07910	COG0438	transferase activity, transferring glycosyl groups
FOC62_RS07915	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FOC62_RS07925	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FOC62_RS07930	COG2610	gluconate transmembrane transporter activity
FOC62_RS07935	COG1070	Carbohydrate kinase
FOC62_RS07940	COG1802	Transcriptional regulator
FOC62_RS07950	COG2357	RelA SpoT domain protein
FOC62_RS07955	COG4876	unkown
FOC62_RS07970	COG2271	Major facilitator Superfamily
FOC62_RS07975	COG0352	thiamine-phosphate diphosphorylase activity
FOC62_RS07980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FOC62_RS07990	COG2022	thiamine diphosphate biosynthetic process
FOC62_RS07995	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FOC62_RS08000	COG0586	Pfam SNARE associated Golgi protein
FOC62_RS08005	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
FOC62_RS08015	COG3949	Membrane
FOC62_RS08020	COG1012	belongs to the aldehyde dehydrogenase family
FOC62_RS08025	COG0583	DNA-binding transcription factor activity
FOC62_RS08040	COG2514	catechol 2,3-dioxygenase activity
FOC62_RS08045	COG2314	TM2 domain
FOC62_RS08065	COG1012	belongs to the aldehyde dehydrogenase family
FOC62_RS08070	COG0778	Nitroreductase
FOC62_RS08075	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FOC62_RS08080	COG0561	phosphatase activity
FOC62_RS08085	COG3764	Sortase (surface protein transpeptidase)
FOC62_RS08100	COG1760	l-serine dehydratase
FOC62_RS08105	COG1760	l-serine dehydratase
FOC62_RS08115	COG1070	Carbohydrate kinase
FOC62_RS08135	COG2843	Capsule synthesis protein
FOC62_RS08145	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FOC62_RS08160	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FOC62_RS08165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FOC62_RS08190	COG0028	Belongs to the TPP enzyme family
FOC62_RS08195	COG1346	cytolysis
FOC62_RS08200	COG1380	Effector of murein hydrolase LrgA
FOC62_RS08205	COG0583	DNA-binding transcription factor activity
FOC62_RS08215	COG3942	CHAP domain
FOC62_RS08215	COG1388	LysM domain
FOC62_RS08225	COG3425	synthase
FOC62_RS08230	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FOC62_RS08260	COG1012	belongs to the aldehyde dehydrogenase family
FOC62_RS08270	COG1028	Short-chain dehydrogenase reductase Sdr
FOC62_RS08285	COG2608	mercury ion transmembrane transporter activity
FOC62_RS08295	COG0436	Aminotransferase
FOC62_RS08310	COG0741	lytic transglycosylase activity
FOC62_RS08325	COG1113	amino acid transport
FOC62_RS08360	COG1028	Short-chain dehydrogenase reductase Sdr
FOC62_RS08370	COG0596	Alpha beta hydrolase
FOC62_RS08375	COG3001	Fructosamine kinase
FOC62_RS08380	COG0167	dihydroorotate dehydrogenase activity
FOC62_RS08390	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FOC62_RS08435	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FOC62_RS08440	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FOC62_RS08450	COG3527	Alpha-acetolactate decarboxylase
FOC62_RS08460	COG0039	L-malate dehydrogenase activity
FOC62_RS08465	COG0583	DNA-binding transcription factor activity
FOC62_RS08475	COG0531	amino acid
FOC62_RS08500	COG0446	pyridine nucleotide-disulphide oxidoreductase
FOC62_RS08510	COG3588	fructose-bisphosphate aldolase
FOC62_RS08530	COG2723	6-phospho-beta-galactosidase activity
FOC62_RS08540	COG2188	Transcriptional regulator
FOC62_RS08545	COG2801	Transposase and inactivated derivatives
FOC62_RS08550	COG2801	Transposase and inactivated derivatives
FOC62_RS08560	COG0579	oxidoreductase
FOC62_RS08565	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
FOC62_RS08570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FOC62_RS08570	COG0574	Belongs to the PEP-utilizing enzyme family
FOC62_RS08575	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FOC62_RS08595	COG1473	amidohydrolase
FOC62_RS08600	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
FOC62_RS08605	COG1012	belongs to the aldehyde dehydrogenase family
FOC62_RS08610	COG1510	regulation of RNA biosynthetic process
FOC62_RS08620	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FOC62_RS08630	COG1328	CTP reductase activity
FOC62_RS08635	COG3942	CHAP domain
FOC62_RS08645	COG0529	Catalyzes the synthesis of activated sulfate
FOC62_RS08650	COG2046	Belongs to the sulfate adenylyltransferase family
FOC62_RS08655	COG0730	response to heat
FOC62_RS08670	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FOC62_RS08675	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FOC62_RS08680	COG0175	sulfate reduction
FOC62_RS08710	COG1136	(ABC) transporter
FOC62_RS08715	COG2205	protein histidine kinase activity
FOC62_RS08720	COG0745	RESPONSE REGULATOR receiver
FOC62_RS08730	COG1785	Belongs to the alkaline phosphatase family
FOC62_RS08740	COG4195	phage-related replication protein
FOC62_RS08750	COG3961	Belongs to the TPP enzyme family
FOC62_RS08765	COG2843	Capsule synthesis protein
FOC62_RS08770	COG3227	Zinc metalloprotease (Elastase)
FOC62_RS08775	COG0739	heme binding
FOC62_RS08785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FOC62_RS08800	COG3942	CHAP domain
FOC62_RS08800	COG1705	Flagellar rod assembly protein muramidase FlgJ
FOC62_RS08810	COG1764	response to oxidative stress
FOC62_RS08820	COG2409	Drug exporters of the RND superfamily
FOC62_RS08840	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FOC62_RS08845	COG0477	Major facilitator Superfamily
FOC62_RS08900	COG3639	organic phosphonate transmembrane transporter activity
FOC62_RS08920	COG0737	Belongs to the 5'-nucleotidase family
FOC62_RS08925	COG2814	Major facilitator Superfamily
FOC62_RS08945	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
FOC62_RS08970	COG1288	antiporter activity
FOC62_RS09005	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
FOC62_RS09020	COG1695	Transcriptional regulator
FOC62_RS09030	COG0471	metal ion transport
FOC62_RS09035	COG2962	Rard protein
FOC62_RS09040	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
FOC62_RS09050	COG4221	oxidoreductase activity
FOC62_RS09065	COG1136	(ABC) transporter
FOC62_RS09070	COG2205	protein histidine kinase activity
FOC62_RS09080	COG1131	(ABC) transporter
FOC62_RS09085	COG0745	RESPONSE REGULATOR receiver
FOC62_RS09125	COG1785	Belongs to the alkaline phosphatase family
FOC62_RS09205	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FOC62_RS09225	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FOC62_RS09230	COG1288	antiporter activity
FOC62_RS09240	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FOC62_RS09245	COG1882	Formate acetyltransferase
FOC62_RS09250	COG1876	peptidase activity
FOC62_RS09255	COG2910	NAD(P)H-binding
FOC62_RS09265	COG2259	Doxx family
FOC62_RS09280	COG0656	L-ascorbic acid biosynthetic process
FOC62_RS09285	COG0789	Transcriptional regulator
FOC62_RS09290	COG1124	(ABC) transporter
FOC62_RS09295	COG0444	Belongs to the ABC transporter superfamily
FOC62_RS09300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FOC62_RS09305	COG0601	transmembrane transport
FOC62_RS09310	COG0747	negative chemotaxis
FOC62_RS09325	COG0201	protein transport
FOC62_RS09335	COG1073	alpha beta
FOC62_RS09345	COG0653	protein targeting
FOC62_RS09350	COG0438	transferase activity, transferring glycosyl groups
FOC62_RS09415	COG0659	secondary active sulfate transmembrane transporter activity
FOC62_RS09420	COG1438	arginine binding
FOC62_RS09425	COG2235	arginine
FOC62_RS09450	COG2814	Major facilitator Superfamily
FOC62_RS09455	COG1114	Component of the transport system for branched-chain amino acids
FOC62_RS09460	COG0110	maltose O-acetyltransferase activity
FOC62_RS09465	COG2808	Putative FMN-binding domain
FOC62_RS09490	COG2226	methyltransferase
FOC62_RS09500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FOC62_RS09505	COG2814	Major facilitator Superfamily
FOC62_RS09510	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
FOC62_RS09515	COG2851	Citrate transporter
FOC62_RS09520	COG2311	Membrane
FOC62_RS09535	COG0697	spore germination
FOC62_RS09570	COG3223	Belongs to the PsiE family
FOC62_RS09575	COG0542	response to heat
FOC62_RS09590	COG0464	growth
FOC62_RS09605	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FOC62_RS09630	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FOC62_RS09640	COG4863	YycH protein
FOC62_RS09645	COG5002	protein histidine kinase activity
FOC62_RS09650	COG0745	RESPONSE REGULATOR receiver
FOC62_RS09670	COG0305	Participates in initiation and elongation during chromosome replication
FOC62_RS09675	COG0359	binds to the 23S rRNA
FOC62_RS09680	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
FOC62_RS09690	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FOC62_RS09700	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FOC62_RS09715	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FOC62_RS09720	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FOC62_RS09725	COG0187	DNA topoisomerase II activity
FOC62_RS09730	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FOC62_RS09735	COG2501	S4 domain
FOC62_RS09740	COG0592	DNA-directed DNA polymerase activity
FOC62_RS09745	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FOC62_RS09755	COG0594	ribonuclease P activity
FOC62_RS09760	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FOC62_RS09765	COG0445	tRNA wobble uridine modification
FOC62_RS09770	COG0357	Ribosomal RNA small subunit methyltransferase G
FOC62_RS09775	COG1475	DNA binding
FOC62_RS09815	COG1136	(ABC) transporter
FOC62_RS09820	COG0577	efflux transmembrane transporter activity
FOC62_RS09890	COG0577	efflux transmembrane transporter activity
FOC62_RS09895	COG1136	(ABC) transporter
FOC62_RS09915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FOC62_RS09925	COG1476	TRANSCRIPTIONal
FOC62_RS09970	COG2207	Transcriptional regulator
FOC62_RS09975	COG0800	Aldolase
FOC62_RS09980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FOC62_RS09985	COG2211	Major facilitator Superfamily
FOC62_RS09990	COG1904	glucuronate isomerase
FOC62_RS09995	COG1312	Catalyzes the dehydration of D-mannonate
FOC62_RS10000	COG1028	Short-chain dehydrogenase reductase Sdr
FOC62_RS10005	COG3250	beta-galactosidase activity
FOC62_RS10010	COG0183	Belongs to the thiolase family
FOC62_RS10015	COG2801	Transposase and inactivated derivatives
FOC62_RS10040	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FOC62_RS10045	COG0646	methionine synthase
FOC62_RS10045	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FOC62_RS10050	COG0626	cystathionine gamma-synthase activity
FOC62_RS10055	COG0626	cystathionine gamma-synthase activity
FOC62_RS10060	COG1475	DNA binding
FOC62_RS10065	COG0668	transmembrane transport
FOC62_RS10070	COG4481	Protein conserved in bacteria
FOC62_RS10075	COG0012	GTP binding
FOC62_RS10090	COG0360	Binds together with S18 to 16S ribosomal RNA
FOC62_RS10100	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FOC62_RS10105	COG0582	viral genome integration into host DNA
FOC62_RS10185	COG3728	DNA packaging
FOC62_RS10185	COG5484	DNA packaging
FOC62_RS10210	COG1280	lysine exporter protein (LysE YggA)
FOC62_RS10235	COG3634	alkyl hydroperoxide reductase activity
FOC62_RS10240	COG0450	alkyl hydroperoxide reductase
FOC62_RS10255	COG3279	Response regulator of the LytR AlgR family
FOC62_RS10260	COG0778	Nitroreductase
FOC62_RS10265	COG1823	symporter activity
FOC62_RS10270	COG0463	Glycosyl transferase, family 2
FOC62_RS10270	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FOC62_RS10275	COG5183	chlorophyll binding
FOC62_RS10290	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FOC62_RS10295	COG2233	PERMEase
FOC62_RS10300	COG0516	GMP reductase activity
FOC62_RS10300	COG0517	IMP dehydrogenase activity
FOC62_RS10305	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FOC62_RS10305	COG0519	Catalyzes the synthesis of GMP from XMP
FOC62_RS10315	COG0523	cobalamin synthesis protein
FOC62_RS10330	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FOC62_RS10335	COG3002	Belongs to the UPF0753 family
FOC62_RS10340	COG5609	conserved protein (DUF2294)
FOC62_RS10355	COG0671	phosphoesterase, PA-phosphatase related
FOC62_RS10360	COG1647	Serine aminopeptidase, S33
FOC62_RS10370	COG0733	neurotransmitter:sodium symporter activity
FOC62_RS10375	COG1279	arginine transmembrane transporter activity
FOC62_RS10390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FOC62_RS10395	COG0626	cystathionine gamma-synthase activity
FOC62_RS10400	COG1846	Transcriptional regulator
FOC62_RS10425	COG3759	membrane
FOC62_RS10430	COG1278	Cold shock
FOC62_RS10460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FOC62_RS10475	COG0583	DNA-binding transcription factor activity
FOC62_RS10480	COG0067	glutamate synthase
FOC62_RS10480	COG0069	glutamate synthase activity
FOC62_RS10480	COG0070	glutamate synthase
FOC62_RS10485	COG0493	'glutamate synthase
FOC62_RS10495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
FOC62_RS10495	COG1263	PTS System
FOC62_RS10500	COG0366	Alpha amylase catalytic
FOC62_RS10505	COG2188	Transcriptional regulator
FOC62_RS10520	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FOC62_RS10525	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FOC62_RS10530	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FOC62_RS10550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FOC62_RS10555	COG1982	Orn Lys Arg decarboxylase major
FOC62_RS10565	COG3870	Protein conserved in bacteria
FOC62_RS10570	COG0470	DNA polymerase III
FOC62_RS10575	COG1774	PSP1 C-terminal conserved region
FOC62_RS10580	COG4467	Involved in initiation control of chromosome replication
FOC62_RS10585	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FOC62_RS10590	COG2827	Endonuclease containing a URI domain
FOC62_RS10595	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FOC62_RS10600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FOC62_RS10600	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FOC62_RS10605	COG0084	hydrolase, TatD family'
FOC62_RS10610	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
FOC62_RS10615	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FOC62_RS10620	COG4466	Protein conserved in bacteria
FOC62_RS10625	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FOC62_RS10630	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FOC62_RS10635	COG0251	oxidation-reduction process
FOC62_RS10640	COG2088	sporulation resulting in formation of a cellular spore
FOC62_RS10645	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FOC62_RS10650	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FOC62_RS10655	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FOC62_RS10660	COG0193	aminoacyl-tRNA hydrolase activity
FOC62_RS10665	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FOC62_RS10670	COG2244	polysaccharide biosynthetic process
FOC62_RS10675	COG3956	TIGRFAM MazG family protein
FOC62_RS10680	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FOC62_RS10690	COG1098	S1 RNA binding domain
FOC62_RS10705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FOC62_RS10725	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FOC62_RS10730	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FOC62_RS10735	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FOC62_RS10820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FOC62_RS10825	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
FOC62_RS10830	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
FOC62_RS10835	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FOC62_RS10845	COG3880	PFAM UvrB UvrC protein
FOC62_RS10850	COG3869	Catalyzes the specific phosphorylation of arginine residues in
FOC62_RS10855	COG0542	response to heat
FOC62_RS10860	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FOC62_RS10865	COG4956	integral membrane protein (PIN domain superfamily)
FOC62_RS10870	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FOC62_RS10880	COG0215	cysteine-tRNA ligase activity
FOC62_RS10885	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
FOC62_RS10895	COG3688	RNA-binding protein containing a PIN domain
FOC62_RS10905	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FOC62_RS10915	COG0250	Participates in transcription elongation, termination and antitermination
FOC62_RS10920	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FOC62_RS10925	COG0081	regulation of translation
FOC62_RS10930	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FOC62_RS10935	COG0222	ribosome binding
FOC62_RS10940	COG2813	Specifically methylates the guanine in position
FOC62_RS10945	COG0085	RNA polymerase activity
FOC62_RS10950	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FOC62_RS10960	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FOC62_RS10965	COG0049	tRNA binding
FOC62_RS10970	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FOC62_RS10975	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FOC62_RS10980	COG1473	amidohydrolase
FOC62_RS11000	COG1349	DNA-binding transcription factor activity
FOC62_RS11005	COG2814	Major facilitator Superfamily
FOC62_RS11010	COG1063	alcohol dehydrogenase
FOC62_RS11025	COG0737	Belongs to the 5'-nucleotidase family
FOC62_RS11035	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FOC62_RS11045	COG1428	Deoxynucleoside kinase
FOC62_RS11050	COG1428	Deoxynucleoside kinase
FOC62_RS11060	COG0561	phosphatase activity
FOC62_RS11065	COG0431	NADPH-dependent FMN reductase
FOC62_RS11070	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
FOC62_RS11070	COG3266	domain, Protein
FOC62_RS11070	COG4932	domain protein
FOC62_RS11095	COG2271	Major facilitator Superfamily
FOC62_RS11100	COG1469	GTP cyclohydrolase I activity
FOC62_RS11105	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FOC62_RS11115	COG0363	glucosamine-6-phosphate deaminase activity
FOC62_RS11120	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
FOC62_RS11135	COG0477	Major facilitator Superfamily
FOC62_RS11160	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
FOC62_RS11175	COG2363	Small membrane protein
FOC62_RS11200	COG0280	phosphate acetyltransferase
FOC62_RS11205	COG0095	Lipoate-protein ligase
FOC62_RS11210	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FOC62_RS11225	COG4844	belongs to the
FOC62_RS11230	COG0667	Aldo Keto reductase
FOC62_RS11235	COG0655	NAD(P)H dehydrogenase (quinone) activity
FOC62_RS11245	COG1078	dGTPase activity
FOC62_RS11265	COG0018	arginyl-trna synthetase
FOC62_RS11270	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FOC62_RS11280	COG0534	Mate efflux family protein
FOC62_RS11285	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FOC62_RS11290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOC62_RS11295	COG0546	phosphoglycolate phosphatase activity
FOC62_RS11315	COG2267	carboxylic ester hydrolase activity
FOC62_RS11355	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FOC62_RS11355	COG2111	Na H antiporter
FOC62_RS11360	COG2111	Na H antiporter
FOC62_RS11365	COG1006	Multisubunit Na H antiporter MnhC subunit
FOC62_RS11370	COG0651	ATP synthesis coupled electron transport
FOC62_RS11375	COG1863	multisubunit Na H antiporter MnhE subunit
FOC62_RS11385	COG1320	monovalent cation:proton antiporter activity
FOC62_RS11395	COG0803	Belongs to the bacterial solute-binding protein 9 family
FOC62_RS11400	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FOC62_RS11405	COG1121	(ABC) transporter
FOC62_RS11420	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
FOC62_RS11425	COG1134	teichoic acid transport
FOC62_RS11430	COG1682	transport, permease protein
FOC62_RS11435	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FOC62_RS11445	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FOC62_RS11450	COG1686	Belongs to the peptidase S11 family
FOC62_RS11455	COG1132	(ABC) transporter
FOC62_RS11460	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FOC62_RS11465	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
FOC62_RS11470	COG1120	ATPase activity
FOC62_RS11475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOC62_RS11480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOC62_RS11485	COG2376	Dihydroxyacetone kinase
FOC62_RS11495	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
FOC62_RS11505	COG3949	Membrane
FOC62_RS11520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FOC62_RS11530	COG2205	protein histidine kinase activity
FOC62_RS11535	COG1136	(ABC) transporter
FOC62_RS11540	COG0577	efflux transmembrane transporter activity
FOC62_RS11550	COG1392	Phosphate transport regulator
FOC62_RS11555	COG0306	phosphate transporter
FOC62_RS11560	COG1388	LysM domain
FOC62_RS11560	COG3942	CHAP domain
FOC62_RS11570	COG2207	Transcriptional regulator
FOC62_RS11570	COG0662	Cupin 2, conserved barrel domain protein
FOC62_RS11580	COG0217	transcriptional regulatory protein
FOC62_RS11595	COG0583	DNA-binding transcription factor activity
FOC62_RS11600	COG2814	Major facilitator Superfamily
FOC62_RS11605	COG2839	Protein conserved in bacteria
FOC62_RS11630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FOC62_RS11640	COG1959	2 iron, 2 sulfur cluster binding
FOC62_RS11645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FOC62_RS11650	COG1611	Belongs to the LOG family
FOC62_RS11655	COG1671	Belongs to the UPF0178 family
FOC62_RS11665	COG1968	undecaprenyl-diphosphatase activity
FOC62_RS11670	COG4988	ABC transporter
FOC62_RS11675	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
FOC62_RS11685	COG0523	cobalamin synthesis protein
FOC62_RS11690	COG4989	oxidoreductase activity
FOC62_RS11700	COG0039	L-malate dehydrogenase activity
FOC62_RS11705	COG0471	metal ion transport
FOC62_RS11735	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FOC62_RS11740	COG1349	DNA-binding transcription factor activity
FOC62_RS11745	COG1105	Belongs to the carbohydrate kinase PfkB family
FOC62_RS11750	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
FOC62_RS11750	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FOC62_RS11750	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
FOC62_RS11755	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FOC62_RS11760	COG1253	flavin adenine dinucleotide binding
FOC62_RS11765	COG0656	L-ascorbic acid biosynthetic process
FOC62_RS11770	COG0463	Glycosyl transferase, family 2
FOC62_RS11780	COG0602	queuosine metabolic process
FOC62_RS11785	COG0720	synthase
FOC62_RS11790	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FOC62_RS11795	COG0512	Glutamine amidotransferase of anthranilate synthase
FOC62_RS11795	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FOC62_RS11800	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FOC62_RS11805	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FOC62_RS11825	COG1368	sulfuric ester hydrolase activity
FOC62_RS11835	COG0488	(ABC) transporter
FOC62_RS11840	COG0514	ATP-dependent DNA helicase (RecQ)
FOC62_RS11845	COG0517	IMP dehydrogenase activity
FOC62_RS11845	COG1125	glycine betaine transport
FOC62_RS11850	COG1174	glycine betaine transport
FOC62_RS11855	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FOC62_RS11865	COG1597	lipid kinase activity
FOC62_RS11870	COG3104	oligopeptide transport
FOC62_RS11885	COG1780	Probably involved in ribonucleotide reductase function
FOC62_RS11890	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FOC62_RS11895	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FOC62_RS11900	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOC62_RS11905	COG4605	iron ion homeostasis
FOC62_RS11910	COG4604	ABC transporter, ATP-binding protein
FOC62_RS11925	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FOC62_RS11945	COG1929	Belongs to the glycerate kinase type-1 family
FOC62_RS11950	COG2195	Cleaves the N-terminal amino acid of tripeptides
FOC62_RS11970	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FOC62_RS11975	COG1739	Uncharacterized protein family UPF0029
FOC62_RS11990	COG1040	competence protein
FOC62_RS11995	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FOC62_RS12000	COG0653	protein targeting
FOC62_RS12010	COG1388	LysM domain
FOC62_RS12010	COG3942	CHAP domain
FOC62_RS12025	COG0556	nucleotide-excision repair
FOC62_RS12030	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FOC62_RS12040	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins