locus-tag	class	description
A284_RS12410	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A284_RS12415	COG0592	DNA-directed DNA polymerase activity
A284_RS12420	COG2501	S4 domain
A284_RS12425	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A284_RS12430	COG0187	DNA topoisomerase II activity
A284_RS12435	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A284_RS12440	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A284_RS12455	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A284_RS12465	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A284_RS12480	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
A284_RS12485	COG0359	binds to the 23S rRNA
A284_RS12490	COG0305	Participates in initiation and elongation during chromosome replication
A284_RS12510	COG0745	RESPONSE REGULATOR receiver
A284_RS12515	COG5002	protein histidine kinase activity
A284_RS12520	COG4863	YycH protein
A284_RS12530	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A284_RS12540	COG1401	restriction endodeoxyribonuclease activity
A284_RS12580	COG3223	Belongs to the PsiE family
A284_RS12590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A284_RS12595	COG1733	regulation of RNA biosynthetic process
A284_RS12640	COG2851	Citrate transporter
A284_RS12645	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A284_RS12650	COG2814	Major facilitator Superfamily
A284_RS12655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A284_RS12660	COG2226	methyltransferase
A284_RS12665	COG5564	TIM-barrel signal transduction protein
A284_RS12675	COG5564	TIM-barrel signal transduction protein
A284_RS12700	COG2808	Putative FMN-binding domain
A284_RS12705	COG0110	maltose O-acetyltransferase activity
A284_RS12710	COG1114	Component of the transport system for branched-chain amino acids
A284_RS12715	COG2814	Major facilitator Superfamily
A284_RS12755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A284_RS12760	COG1609	Transcriptional regulator
A284_RS12770	COG1869	D-ribose catabolic process
A284_RS12790	COG2814	Major facilitator Superfamily
A284_RS12810	COG1131	(ABC) transporter
A284_RS12840	COG0601	transmembrane transport
A284_RS12850	COG0444	Belongs to the ABC transporter superfamily
A284_RS12855	COG1124	(ABC) transporter
A284_RS12865	COG0346	lactoylglutathione lyase activity
A284_RS12875	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A284_RS12905	COG1733	regulation of RNA biosynthetic process
A284_RS12915	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A284_RS12920	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A284_RS12930	COG0166	Belongs to the GPI family
A284_RS12935	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A284_RS12965	COG0583	DNA-binding transcription factor activity
A284_RS12990	COG1250	3-hydroxyacyl-CoA dehydrogenase
A284_RS12995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A284_RS13015	COG2235	arginine
A284_RS13020	COG1438	arginine binding
A284_RS13025	COG0659	secondary active sulfate transmembrane transporter activity
A284_RS13045	COG2814	Major facilitator Superfamily
A284_RS13070	COG0438	transferase activity, transferring glycosyl groups
A284_RS13075	COG0653	protein targeting
A284_RS13085	COG1073	alpha beta
A284_RS13095	COG0201	protein transport
A284_RS13110	COG0747	negative chemotaxis
A284_RS13115	COG0601	transmembrane transport
A284_RS13120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A284_RS13130	COG1124	(ABC) transporter
A284_RS13135	COG0789	Transcriptional regulator
A284_RS13155	COG2259	Doxx family
A284_RS13165	COG1959	2 iron, 2 sulfur cluster binding
A284_RS13170	COG2910	NAD(P)H-binding
A284_RS13175	COG1876	peptidase activity
A284_RS13180	COG1882	Formate acetyltransferase
A284_RS13185	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A284_RS13195	COG1288	antiporter activity
A284_RS13200	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A284_RS13205	COG0463	Glycosyl transferase, family 2
A284_RS13205	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A284_RS13220	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A284_RS13270	COG1785	Belongs to the alkaline phosphatase family
A284_RS13305	COG0745	RESPONSE REGULATOR receiver
A284_RS13310	COG1131	(ABC) transporter
A284_RS13320	COG2205	protein histidine kinase activity
A284_RS13330	COG2720	vancomycin resistance protein
A284_RS13335	COG1136	(ABC) transporter
A284_RS13350	COG4221	oxidoreductase activity
A284_RS13355	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
A284_RS13360	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
A284_RS13365	COG2962	Rard protein
A284_RS13370	COG0471	metal ion transport
A284_RS13380	COG1695	Transcriptional regulator
A284_RS13395	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
A284_RS13400	COG1054	Belongs to the UPF0176 family
A284_RS13425	COG1288	antiporter activity
A284_RS13430	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A284_RS13435	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A284_RS13450	COG2814	Major facilitator Superfamily
A284_RS13455	COG0737	Belongs to the 5'-nucleotidase family
A284_RS13470	COG3639	organic phosphonate transmembrane transporter activity
A284_RS13530	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A284_RS13550	COG2113	Glycine betaine
A284_RS13555	COG2409	Drug exporters of the RND superfamily
A284_RS13560	COG1764	response to oxidative stress
A284_RS13570	COG3942	CHAP domain
A284_RS13570	COG1705	Flagellar rod assembly protein muramidase FlgJ
A284_RS13590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A284_RS13600	COG0739	heme binding
A284_RS13605	COG3227	Zinc metalloprotease (Elastase)
A284_RS13610	COG2843	Capsule synthesis protein
A284_RS13625	COG3961	Belongs to the TPP enzyme family
A284_RS13635	COG4195	phage-related replication protein
A284_RS13645	COG0745	RESPONSE REGULATOR receiver
A284_RS13650	COG2205	protein histidine kinase activity
A284_RS13655	COG1136	(ABC) transporter
A284_RS13685	COG0175	sulfate reduction
A284_RS13690	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A284_RS13695	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A284_RS13710	COG0730	response to heat
A284_RS13715	COG2046	Belongs to the sulfate adenylyltransferase family
A284_RS13720	COG0529	Catalyzes the synthesis of activated sulfate
A284_RS13730	COG3942	CHAP domain
A284_RS13735	COG1328	CTP reductase activity
A284_RS13740	COG0602	queuosine metabolic process
A284_RS13750	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A284_RS13760	COG1510	regulation of RNA biosynthetic process
A284_RS13765	COG1012	belongs to the aldehyde dehydrogenase family
A284_RS13770	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A284_RS13775	COG1473	amidohydrolase
A284_RS13795	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A284_RS13800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A284_RS13800	COG0574	Belongs to the PEP-utilizing enzyme family
A284_RS13805	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A284_RS13810	COG0579	oxidoreductase
A284_RS13815	COG2723	6-phospho-beta-galactosidase activity
A284_RS13825	COG1695	Transcriptional regulator
A284_RS13835	COG3588	fructose-bisphosphate aldolase
A284_RS13840	COG0563	adenylate kinase activity
A284_RS13850	COG0446	pyridine nucleotide-disulphide oxidoreductase
A284_RS13870	COG0531	amino acid
A284_RS13880	COG0583	DNA-binding transcription factor activity
A284_RS13885	COG0039	L-malate dehydrogenase activity
A284_RS13890	COG0028	Belongs to the TPP enzyme family
A284_RS13895	COG3527	Alpha-acetolactate decarboxylase
A284_RS13905	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A284_RS13910	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A284_RS13925	COG4640	response to antibiotic
A284_RS13955	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A284_RS13965	COG0167	dihydroorotate dehydrogenase activity
A284_RS13970	COG3001	Fructosamine kinase
A284_RS13975	COG0596	Alpha beta hydrolase
A284_RS13985	COG4221	oxidoreductase activity
A284_RS14020	COG1113	amino acid transport
A284_RS14035	COG1388	LysM domain
A284_RS14050	COG0436	Aminotransferase
A284_RS14060	COG2608	mercury ion transmembrane transporter activity
A284_RS14075	COG1028	Short-chain dehydrogenase reductase Sdr
A284_RS14085	COG1012	belongs to the aldehyde dehydrogenase family
A284_RS14115	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A284_RS14120	COG3425	synthase
A284_RS14130	COG1388	LysM domain
A284_RS14130	COG3942	CHAP domain
A284_RS14140	COG0583	DNA-binding transcription factor activity
A284_RS14145	COG1380	Effector of murein hydrolase LrgA
A284_RS14150	COG1346	cytolysis
A284_RS14155	COG0028	Belongs to the TPP enzyme family
A284_RS14180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A284_RS14185	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A284_RS14190	COG0657	acetylesterase activity
A284_RS14200	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A284_RS14210	COG2843	Capsule synthesis protein
A284_RS14225	COG1070	Carbohydrate kinase
A284_RS14235	COG1760	l-serine dehydratase
A284_RS14240	COG1760	l-serine dehydratase
A284_RS14250	COG3764	Sortase (surface protein transpeptidase)
A284_RS14255	COG0561	phosphatase activity
A284_RS14265	COG0778	Nitroreductase
A284_RS14270	COG1012	belongs to the aldehyde dehydrogenase family
A284_RS14290	COG2314	TM2 domain
A284_RS14295	COG2514	catechol 2,3-dioxygenase activity
A284_RS14310	COG0583	DNA-binding transcription factor activity
A284_RS14315	COG1012	belongs to the aldehyde dehydrogenase family
A284_RS14320	COG3949	Membrane
A284_RS14330	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
A284_RS14335	COG0586	Pfam SNARE associated Golgi protein
A284_RS14340	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A284_RS14345	COG2022	thiamine diphosphate biosynthetic process
A284_RS14360	COG0352	thiamine-phosphate diphosphorylase activity
A284_RS14365	COG2271	Major facilitator Superfamily
A284_RS14370	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
A284_RS14380	COG4876	unkown
A284_RS14385	COG2357	RelA SpoT domain protein
A284_RS14395	COG1802	Transcriptional regulator
A284_RS14400	COG1070	Carbohydrate kinase
A284_RS14405	COG2610	gluconate transmembrane transporter activity
A284_RS14410	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A284_RS14425	COG1215	transferase activity, transferring glycosyl groups
A284_RS14430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A284_RS14435	COG0494	nUDIX hydrolase
A284_RS14445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A284_RS14450	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A284_RS14455	COG0022	dehydrogenase e1 component
A284_RS14460	COG0508	dehydrogenase complex catalyzes the overall conversion of
A284_RS14490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A284_RS14495	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A284_RS14505	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A284_RS14510	COG1028	Short-chain dehydrogenase reductase Sdr
A284_RS14515	COG1363	Peptidase, m42
A284_RS14520	COG4808	Protein conserved in bacteria
A284_RS14540	COG0069	glutamate synthase activity
A284_RS14555	COG4619	ABC transporter
A284_RS14560	COG0390	transport system, permease component
A284_RS14565	COG2814	Major facilitator Superfamily
A284_RS14575	COG0531	amino acid
A284_RS14580	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
A284_RS14605	COG1174	glycine betaine transport
A284_RS14610	COG1346	cytolysis
A284_RS14615	COG1380	Effector of murein hydrolase LrgA
A284_RS14625	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A284_RS14635	COG3477	response to acidic pH
A284_RS14645	COG0706	membrane insertase activity
A284_RS14655	COG0531	amino acid
A284_RS14665	COG1113	amino acid transport
A284_RS14670	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A284_RS14685	COG2814	Major facilitator Superfamily
A284_RS14690	COG1695	Transcriptional regulator
A284_RS14705	COG1929	Belongs to the glycerate kinase type-1 family
A284_RS14720	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A284_RS14725	COG0741	lytic transglycosylase activity
A284_RS14730	COG0588	phosphoglycerate mutase activity
A284_RS14735	COG2814	Major facilitator Superfamily
A284_RS14740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A284_RS14745	COG0765	amino acid transport
A284_RS14750	COG1126	abc transporter atp-binding protein
A284_RS14755	COG2348	transferase activity, transferring amino-acyl groups
A284_RS14770	COG0803	Belongs to the bacterial solute-binding protein 9 family
A284_RS14785	COG0454	-acetyltransferase
A284_RS14800	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A284_RS14805	COG2146	nitrite reductase [NAD(P)H] activity
A284_RS14820	COG1140	nitrate reductase beta subunit
A284_RS14830	COG2181	nitrate reductase activity
A284_RS14850	COG2223	nitrite transmembrane transporter activity
A284_RS14865	COG0778	Nitroreductase
A284_RS14875	COG1301	dicarboxylic acid transport
A284_RS14900	COG1263	PTS System
A284_RS14900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A284_RS14925	COG1028	Short-chain dehydrogenase reductase Sdr
A284_RS14930	COG0583	DNA-binding transcription factor activity
A284_RS14940	COG1028	Short-chain dehydrogenase reductase Sdr
A284_RS14970	COG0492	ferredoxin-NADP+ reductase activity
A284_RS14975	COG0456	acetyltransferase
A284_RS14980	COG0604	alcohol dehydrogenase
A284_RS14985	COG2822	iron ion transport
A284_RS14990	COG2837	iron assimilation
A284_RS14995	COG0672	)-iron permease
A284_RS15000	COG0805	protein transport
A284_RS15005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A284_RS15015	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A284_RS15015	COG0463	Glycosyl transferase, family 2
A284_RS15025	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A284_RS15025	COG0463	Glycosyl transferase, family 2
A284_RS15030	COG1620	l-lactate permease
A284_RS15040	COG0579	oxidoreductase
A284_RS15090	COG2814	Major facilitator Superfamily
A284_RS15100	COG1566	PFAM secretion protein HlyD family protein
A284_RS15105	COG2814	Major facilitator Superfamily
A284_RS15130	COG0598	Magnesium transport protein CorA
A284_RS15135	COG1304	FMN binding
A284_RS15140	COG0786	glutamate:sodium symporter activity
A284_RS15145	COG1695	Transcriptional regulator
A284_RS15160	COG2094	Belongs to the DNA glycosylase MPG family
A284_RS15170	COG1069	ribulokinase activity
A284_RS15175	COG4152	abc transporter atp-binding protein
A284_RS15180	COG1668	transmembrane transport
A284_RS15185	COG1742	UPF0060 membrane protein
A284_RS15190	COG2017	converts alpha-aldose to the beta-anomer
A284_RS15195	COG2258	MOSC domain
A284_RS15200	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A284_RS15210	COG1266	CAAX protease self-immunity
A284_RS15215	COG0010	Belongs to the arginase family
A284_RS15220	COG0583	DNA-binding transcription factor activity
A284_RS15235	COG1473	amidohydrolase
A284_RS15240	COG1028	Short-chain dehydrogenase reductase Sdr
A284_RS15260	COG1737	Transcriptional regulator
A284_RS15265	COG1263	PTS System
A284_RS15265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A284_RS15275	COG0385	Bile acid
A284_RS15280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A284_RS15300	COG1113	amino acid transport
A284_RS15310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A284_RS15310	COG1263	PTS System
A284_RS15315	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A284_RS15330	COG1266	CAAX protease self-immunity
A284_RS15335	COG2378	regulation of single-species biofilm formation
A284_RS15340	COG0483	inositol monophosphate 1-phosphatase activity
A284_RS15345	COG1316	TRANSCRIPTIONal
A284_RS15375	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A284_RS15380	COG2076	Multidrug Resistance protein
A284_RS15385	COG2076	Multidrug Resistance protein
A284_RS15390	COG3942	CHAP domain
A284_RS15405	COG1757	Na H antiporter
A284_RS15410	COG3942	CHAP domain
A284_RS15420	COG1846	Transcriptional regulator
A284_RS15435	COG0829	nickel cation binding
A284_RS15450	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
A284_RS15455	COG0804	urea catabolic process
A284_RS15465	COG0831	urea catabolic process
A284_RS15470	COG4413	Urea transporter
A284_RS15475	COG0765	amino acid transport
A284_RS15480	COG0765	amino acid transport
A284_RS15485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A284_RS15490	COG1126	abc transporter atp-binding protein
A284_RS15495	COG1960	acyl-CoA dehydrogenase activity
A284_RS15510	COG1268	BioY protein
A284_RS15520	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A284_RS15525	COG0725	ABC transporter, periplasmic molybdate-binding protein
A284_RS15530	COG4149	molybdate abc transporter
A284_RS15535	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A284_RS15540	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A284_RS15545	COG0521	Mo-molybdopterin cofactor biosynthetic process
A284_RS15550	COG0315	cyclic pyranopterin monophosphate synthase activity
A284_RS15560	COG1763	Mo-molybdopterin cofactor biosynthetic process
A284_RS15580	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A284_RS15590	COG2814	Major facilitator Superfamily
A284_RS15605	COG2348	transferase activity, transferring amino-acyl groups
A284_RS15610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A284_RS15625	COG1028	Short-chain dehydrogenase reductase Sdr
A284_RS15630	COG4975	Glucose uptake
A284_RS15645	COG2252	PERMEase
A284_RS15660	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A284_RS15665	COG0088	Forms part of the polypeptide exit tunnel
A284_RS15670	COG0089	rRNA binding
A284_RS15675	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A284_RS15680	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A284_RS15685	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A284_RS15690	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A284_RS15695	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A284_RS15705	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A284_RS15710	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A284_RS15715	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A284_RS15725	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A284_RS15730	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A284_RS15735	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A284_RS15740	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A284_RS15745	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A284_RS15750	COG1841	ribosomal large subunit assembly
A284_RS15760	COG0201	protein transport
A284_RS15765	COG0563	adenylate kinase activity
A284_RS15770	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A284_RS15780	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A284_RS15785	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A284_RS15790	COG0202	RNA polymerase activity
A284_RS15805	COG1122	ATPase activity
A284_RS15820	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A284_RS15825	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A284_RS15835	COG0789	Transcriptional regulator
A284_RS15850	COG0698	ribose 5-phosphate isomerase
A284_RS15890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A284_RS15895	COG2130	NADP-dependent
A284_RS15900	COG0604	alcohol dehydrogenase
A284_RS15905	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A284_RS15920	COG1302	Protein conserved in bacteria
A284_RS15930	COG2814	Major facilitator Superfamily
A284_RS15935	COG4264	IucA IucC family
A284_RS15940	COG3457	Alanine racemase
A284_RS15945	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A284_RS15950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A284_RS15955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A284_RS15960	COG3314	Sporulation integral membrane protein YlbJ
A284_RS15965	COG2329	Antibiotic biosynthesis monooxygenase
A284_RS15975	COG1988	membrane-bound metal-dependent
A284_RS15980	COG4284	Utp--glucose-1-phosphate uridylyltransferase
A284_RS15985	COG1272	protein, Hemolysin III
A284_RS16000	COG2814	Major facilitator Superfamily
A284_RS16005	COG0477	Major facilitator Superfamily
A284_RS16010	COG0489	protein tyrosine kinase activity
A284_RS16065	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A284_RS16090	COG3711	transcriptional antiterminator
A284_RS16105	COG0561	phosphatase activity
A284_RS16125	COG0640	Transcriptional regulator
A284_RS16130	COG0702	epimerase
A284_RS16135	COG1482	cell wall glycoprotein biosynthetic process
A284_RS16155	COG0783	Belongs to the Dps family
A284_RS16160	COG0813	purine-nucleoside phosphorylase activity
A284_RS16165	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A284_RS16170	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A284_RS16175	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A284_RS16185	COG1854	S-ribosylhomocysteine lyase activity
A284_RS16205	COG5146	pantothenate kinase activity
A284_RS16220	COG0504	CTP synthase activity
A284_RS16230	COG0191	fructose-bisphosphate aldolase activity
A284_RS16235	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A284_RS16245	COG1012	belongs to the aldehyde dehydrogenase family
A284_RS16250	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A284_RS16255	COG0254	rRNA binding
A284_RS16260	COG1435	thymidine kinase activity
A284_RS16270	COG2890	protein-(glutamine-N5) methyltransferase activity
A284_RS16275	COG0009	L-threonylcarbamoyladenylate synthase
A284_RS16280	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A284_RS16285	COG4475	Protein of unknown function (DUF436)
A284_RS16295	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A284_RS16300	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A284_RS16320	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A284_RS16330	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A284_RS16335	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A284_RS16340	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A284_RS16355	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A284_RS16370	COG0629	single-stranded DNA binding
A284_RS16375	COG1388	LysM domain
A284_RS16380	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A284_RS16390	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A284_RS16395	COG0352	thiamine-phosphate diphosphorylase activity
A284_RS16400	COG0706	membrane insertase activity
A284_RS16405	COG1418	mRNA catabolic process
A284_RS16410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A284_RS16415	COG1937	Protein conserved in bacteria
A284_RS16430	COG1181	Belongs to the D-alanine--D-alanine ligase family
A284_RS16435	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A284_RS16440	COG0513	Belongs to the DEAD box helicase family
A284_RS16450	COG3428	Bacterial PH domain
A284_RS16460	COG0736	holo-[acyl-carrier-protein] synthase activity
A284_RS16465	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A284_RS16475	COG2337	Toxic component of a toxin-antitoxin (TA) module
A284_RS16480	COG2208	phosphoserine phosphatase activity
A284_RS16495	COG1191	sigma factor activity
A284_RS16500	COG2183	response to ionizing radiation
A284_RS16545	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A284_RS16550	COG0473	3-isopropylmalate dehydrogenase activity
A284_RS16570	COG0028	Belongs to the TPP enzyme family
A284_RS16575	COG0129	dihydroxy-acid dehydratase activity
A284_RS16580	COG0802	atpase or kinase
A284_RS16585	COG1214	PFAM Peptidase M22, glycoprotease
A284_RS16590	COG0456	acetyltransferase
A284_RS16595	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A284_RS16605	COG0488	(ABC) transporter
A284_RS16620	COG2391	methyltransferase activity
A284_RS16625	COG0425	Belongs to the sulfur carrier protein TusA family
A284_RS16630	COG1609	Transcriptional regulator
A284_RS16635	COG1621	beta-fructofuranosidase activity
A284_RS16640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A284_RS16650	COG3290	protein histidine kinase activity
A284_RS16695	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A284_RS16700	COG0459	protein refolding
A284_RS16735	COG1725	Transcriptional regulator
A284_RS16750	COG1131	(ABC) transporter
A284_RS16790	COG2706	6-phosphogluconolactonase activity
A284_RS16795	COG1012	belongs to the aldehyde dehydrogenase family
A284_RS16800	COG1227	inorganic diphosphatase activity
A284_RS16805	COG1335	isochorismatase
A284_RS16815	COG0077	Prephenate dehydratase
A284_RS16825	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A284_RS16830	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A284_RS16835	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
A284_RS16840	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A284_RS16845	COG4496	protein, YerC YecD
A284_RS16850	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
A284_RS16855	COG0210	DNA helicase
A284_RS16860	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A284_RS16870	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A284_RS16885	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A284_RS16890	COG1597	lipid kinase activity
A284_RS16895	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A284_RS16915	COG1528	Iron-storage protein
A284_RS16930	COG4129	membrane
A284_RS16935	COG0024	Methionine aminopeptidase
A284_RS16955	COG2197	response regulator
A284_RS16960	COG1295	ribonuclease BN
A284_RS16975	COG4840	Belongs to the UPF0435 family
A284_RS16980	COG2309	aminopeptidase activity
A284_RS16990	COG0535	radical SAM domain protein
A284_RS16995	COG0693	protein deglycase activity
A284_RS17000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A284_RS17015	COG1388	LysM domain
A284_RS17015	COG1134	teichoic acid transport
A284_RS17025	COG1988	membrane-bound metal-dependent
A284_RS17030	COG1194	a g-specific adenine glycosylase
A284_RS17035	COG3557	Belongs to the UPF0374 family
A284_RS17045	COG4129	membrane
A284_RS17050	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A284_RS17055	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A284_RS17060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A284_RS17065	COG0735	belongs to the Fur family
A284_RS17220	COG0765	amino acid transport
A284_RS17230	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A284_RS17240	COG0363	glucosamine-6-phosphate deaminase activity
A284_RS17255	COG0114	fumarate hydratase activity
A284_RS17260	COG0564	pseudouridine synthase activity
A284_RS17265	COG2203	Gaf domain
A284_RS17265	COG4585	Histidine kinase
A284_RS17270	COG2197	response regulator
A284_RS17280	COG4399	Belongs to the UPF0754 family
A284_RS17285	COG3679	Belongs to the UPF0342 family
A284_RS17290	COG0420	3'-5' exonuclease activity
A284_RS17300	COG3481	metal-dependent phosphohydrolase, HD sub domain
A284_RS17305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A284_RS17320	COG0537	adenosine 5'-monophosphoramidase activity
A284_RS17325	COG1131	(ABC) transporter
A284_RS17330	COG4473	ABC transporter
A284_RS17335	COG2329	Antibiotic biosynthesis monooxygenase
A284_RS17345	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A284_RS17350	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A284_RS17355	COG3545	Serine hydrolase
A284_RS17400	COG0318	PFAM AMP-dependent synthetase and ligase
A284_RS17415	COG0494	nUDIX hydrolase
A284_RS17420	COG1506	peptidase
A284_RS17430	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A284_RS17440	COG0656	L-ascorbic acid biosynthetic process
A284_RS17445	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A284_RS17450	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A284_RS17460	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A284_RS17485	COG5632	N-Acetylmuramoyl-L-alanine amidase
A284_RS17485	COG3266	domain, Protein
A284_RS17485	COG4193	domain, Protein
A284_RS17495	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A284_RS17495	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A284_RS17500	COG0307	riboflavin synthase, alpha
A284_RS17505	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A284_RS17505	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A284_RS17510	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A284_RS17520	COG2267	carboxylic ester hydrolase activity
A284_RS17530	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A284_RS17535	COG1242	4 iron, 4 sulfur cluster binding
A284_RS17540	COG2814	Major facilitator Superfamily
A284_RS17545	COG0495	leucyl-tRNA aminoacylation
A284_RS17550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A284_RS17565	COG2081	HI0933 family
A284_RS17570	COG2244	polysaccharide biosynthetic process
A284_RS17575	COG1187	pseudouridine synthase activity
A284_RS17585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A284_RS17590	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A284_RS17595	COG0510	thiamine kinase activity
A284_RS17600	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A284_RS17605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A284_RS17615	COG1363	Peptidase, m42
A284_RS17620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A284_RS17625	COG4848	Belongs to the UPF0354 family
A284_RS17630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A284_RS17635	COG1674	ftsk spoiiie
A284_RS17640	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A284_RS17655	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A284_RS17655	COG1605	Chorismate mutase
A284_RS17660	COG1609	Transcriptional regulator
A284_RS17670	COG0454	-acetyltransferase
A284_RS17675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A284_RS17685	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A284_RS17700	COG2814	Major facilitator Superfamily
A284_RS17705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A284_RS17710	COG0204	Acyl-transferase
A284_RS17730	COG1263	PTS System
A284_RS17730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A284_RS17740	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A284_RS17745	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A284_RS17750	COG1764	response to oxidative stress
A284_RS17755	COG0584	glycerophosphoryl diester phosphodiesterase
A284_RS17760	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A284_RS17765	COG1956	GAF domain-containing protein
A284_RS17770	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
A284_RS17775	COG1104	cysteine desulfurase activity
A284_RS17780	COG0301	tRNA thio-modification
A284_RS17790	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A284_RS17795	COG0827	DNA restriction-modification system
A284_RS17800	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A284_RS17805	COG0589	response to stress
A284_RS17810	COG0686	Belongs to the AlaDH PNT family
A284_RS17815	COG0006	proline dipeptidase activity
A284_RS17820	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A284_RS17830	COG4109	DRTGG domain
A284_RS17835	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A284_RS17840	COG0587	DNA-directed DNA polymerase activity
A284_RS17845	COG0281	malic enzyme
A284_RS17850	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A284_RS17860	COG0205	6-phosphofructokinase activity
A284_RS17865	COG0469	pyruvate kinase activity
A284_RS17870	COG1113	amino acid transport
A284_RS17875	COG0372	Belongs to the citrate synthase family
A284_RS17880	COG0538	isocitrate dehydrogenase activity
A284_RS17885	COG0745	RESPONSE REGULATOR receiver
A284_RS17890	COG5002	protein histidine kinase activity
A284_RS17895	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A284_RS17895	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A284_RS17900	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A284_RS17910	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A284_RS17915	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A284_RS17920	COG3611	Membrane attachment protein
A284_RS17925	COG1484	DNA-dependent DNA replication
A284_RS17935	COG0833	amino acid
A284_RS17940	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A284_RS17945	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A284_RS17950	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A284_RS17955	COG4112	unkown
A284_RS17965	COG0544	peptidyl-prolyl cis-trans isomerase activity
A284_RS17970	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A284_RS17975	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A284_RS17980	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A284_RS17985	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A284_RS17990	COG0181	hydroxymethylbilane synthase activity
A284_RS18000	COG0113	porphobilinogen synthase activity
A284_RS18005	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A284_RS18015	COG2818	Glycosylase
A284_RS18020	COG0525	valine-tRNA ligase activity
A284_RS18025	COG0285	dihydrofolate synthase activity
A284_RS18035	COG2003	Belongs to the UPF0758 family
A284_RS18065	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A284_RS18070	COG2868	ribosomal protein
A284_RS18075	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A284_RS18080	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A284_RS18085	COG4492	Belongs to the UPF0735 family
A284_RS18090	COG0632	four-way junction helicase activity
A284_RS18100	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A284_RS18110	COG1862	Preprotein translocase
A284_RS18115	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A284_RS18115	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A284_RS18120	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A284_RS18120	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A284_RS18130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A284_RS18140	COG0860	N-Acetylmuramoyl-L-alanine amidase
A284_RS18150	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A284_RS18155	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A284_RS18160	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A284_RS18165	COG1959	2 iron, 2 sulfur cluster binding
A284_RS18170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A284_RS18175	COG1104	cysteine desulfurase activity
A284_RS18180	COG0482	sulfurtransferase activity
A284_RS18190	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A284_RS18200	COG4472	Bacterial protein of unknown function (DUF965)
A284_RS18210	COG3906	Belongs to the UPF0473 family
A284_RS18215	COG4122	O-methyltransferase activity
A284_RS18220	COG0826	peptidase U32
A284_RS18225	COG0826	peptidase U32
A284_RS18230	COG0572	uridine kinase
A284_RS18235	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A284_RS18240	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A284_RS18245	COG1984	allophanate hydrolase subunit 2
A284_RS18250	COG0511	ligase activity, forming carbon-carbon bonds
A284_RS18255	COG0439	Biotin carboxylase
A284_RS18265	COG1914	H( )-stimulated, divalent metal cation uptake system
A284_RS18270	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A284_RS18275	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A284_RS18280	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A284_RS18285	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A284_RS18290	COG1534	Rna-binding protein
A284_RS18295	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A284_RS18300	COG1713	HD superfamily hydrolase involved in NAD metabolism
A284_RS18305	COG0799	negative regulation of ribosome biogenesis
A284_RS18320	COG2131	deaminase
A284_RS18325	COG0658	competence protein
A284_RS18325	COG2333	competence protein COMEC
A284_RS18330	COG1466	dna polymerase III delta subunit
A284_RS18335	COG0268	Binds directly to 16S ribosomal RNA
A284_RS18340	COG0481	GTPase activity
A284_RS18345	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A284_RS18355	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A284_RS18360	COG0443	Heat shock 70 kDa protein
A284_RS18365	COG0484	heat shock protein binding
A284_RS18375	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A284_RS18380	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A284_RS18390	COG1030	water channel activity
A284_RS18395	COG4864	UPF0365 protein
A284_RS18405	COG1702	phosphate starvation-inducible protein PhoH
A284_RS18425	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A284_RS18430	COG1381	Involved in DNA repair and RecF pathway recombination
A284_RS18435	COG0423	glycine-tRNA ligase activity
A284_RS18440	COG0517	IMP dehydrogenase activity
A284_RS18445	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A284_RS18455	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A284_RS18460	COG2384	SAM-dependent methyltransferase
A284_RS18465	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A284_RS18470	COG0513	Belongs to the DEAD box helicase family
A284_RS18475	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A284_RS18480	COG1121	(ABC) transporter
A284_RS18485	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A284_RS18500	COG0768	penicillin binding
A284_RS18505	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A284_RS18510	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A284_RS18520	COG4483	Protein conserved in bacteria
A284_RS18525	COG1940	carbohydrate kinase activity
A284_RS18530	COG0011	TIGRFAM Protein of
A284_RS18535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A284_RS18540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A284_RS18545	COG1459	type II secretion system
A284_RS18550	COG4537	Required for transformation and DNA binding
A284_RS18565	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A284_RS18570	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A284_RS18585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A284_RS18590	COG0095	Lipoate-protein ligase
A284_RS18605	COG0006	proline dipeptidase activity
A284_RS18610	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A284_RS18615	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A284_RS18620	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A284_RS18625	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A284_RS18630	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A284_RS18635	COG0511	ligase activity, forming carbon-carbon bonds
A284_RS18640	COG0439	Biotin carboxylase
A284_RS18645	COG1302	Protein conserved in bacteria
A284_RS18650	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A284_RS18660	COG1722	exodeoxyribonuclease VII activity
A284_RS18665	COG0142	geranyltranstransferase activity
A284_RS18670	COG1438	arginine binding
A284_RS18675	COG0497	DNA recombination
A284_RS18680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A284_RS18685	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A284_RS18690	COG0022	dehydrogenase e1 component
A284_RS18695	COG0508	dehydrogenase complex catalyzes the overall conversion of
A284_RS18705	COG4129	membrane
A284_RS18710	COG2195	Cleaves the N-terminal amino acid of tripeptides
A284_RS18715	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A284_RS18720	COG0366	Alpha amylase catalytic
A284_RS18730	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A284_RS18735	COG1234	tRNA 3'-trailer cleavage
A284_RS18740	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A284_RS18745	COG1028	Short-chain dehydrogenase reductase Sdr
A284_RS18750	COG0667	Aldo Keto reductase
A284_RS18755	COG0494	nUDIX hydrolase
A284_RS18760	COG0735	belongs to the Fur family
A284_RS18765	COG4974	Belongs to the 'phage' integrase family
A284_RS18775	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A284_RS18780	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A284_RS18785	COG1187	pseudouridine synthase activity
A284_RS18790	COG0745	RESPONSE REGULATOR receiver
A284_RS18805	COG1141	Ferredoxin
A284_RS18815	COG0514	ATP-dependent DNA helicase (RecQ)
A284_RS18825	COG0492	ferredoxin-NADP+ reductase activity
A284_RS18830	COG0252	asparaginase activity
A284_RS18835	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A284_RS18840	COG0539	negative regulation of cytoplasmic translation
A284_RS18845	COG1160	GTP binding
A284_RS18850	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A284_RS18865	COG2226	methyltransferase
A284_RS18880	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A284_RS18885	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A284_RS18900	COG5582	Belongs to the UPF0302 family
A284_RS18905	COG4347	Protein of unknown function (DUF1405)
A284_RS18910	COG2738	Putative neutral zinc metallopeptidase
A284_RS18915	COG1694	Mazg nucleotide pyrophosphohydrolase
A284_RS18920	COG0438	transferase activity, transferring glycosyl groups
A284_RS18925	COG0617	tRNA 3'-terminal CCA addition
A284_RS18930	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A284_RS18930	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A284_RS18935	COG1199	ATP-dependent helicase activity
A284_RS18935	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A284_RS18940	COG0017	Asparaginyl-tRNA synthetase
A284_RS18945	COG3935	DnaD domain protein
A284_RS18950	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A284_RS18960	COG4499	WXG100 protein secretion system (Wss), protein YukC
A284_RS18960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A284_RS18965	COG3331	DNA recombination
A284_RS18980	COG3599	regulation of cell shape
A284_RS18985	COG0116	Belongs to the methyltransferase superfamily
A284_RS18995	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A284_RS19000	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A284_RS19015	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A284_RS19020	COG1413	lyase activity
A284_RS19025	COG1413	lyase activity
A284_RS19055	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A284_RS19060	COG2190	(PTS) system
A284_RS19070	COG0793	Belongs to the peptidase S41A family
A284_RS19080	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A284_RS19085	COG0671	phosphoesterase, PA-phosphatase related
A284_RS19090	COG0745	RESPONSE REGULATOR receiver
A284_RS19095	COG5002	protein histidine kinase activity
A284_RS19100	COG0567	Dehydrogenase, E1 component
A284_RS19105	COG0508	dehydrogenase complex catalyzes the overall conversion of
A284_RS19110	COG1131	(ABC) transporter
A284_RS19135	COG0714	Associated with various cellular activities
A284_RS19140	COG4548	von Willebrand factor, type A
A284_RS19145	COG1114	Component of the transport system for branched-chain amino acids
A284_RS19150	COG3853	Toxic anion resistance protein (TelA)
A284_RS19160	COG1254	Belongs to the acylphosphatase family
A284_RS19170	COG1278	Cold shock
A284_RS19185	COG1473	amidohydrolase
A284_RS19195	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A284_RS19200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A284_RS19205	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A284_RS19210	COG0527	aspartate kinase activity
A284_RS19220	COG0488	(ABC) transporter
A284_RS19225	COG2996	Protein conserved in bacteria
A284_RS19230	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A284_RS19235	COG0573	inorganic phosphate transmembrane transporter activity
A284_RS19240	COG0581	inorganic phosphate transmembrane transporter activity
A284_RS19245	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A284_RS19285	COG4607	ABC-type enterochelin transport system periplasmic component
A284_RS19290	COG0561	phosphatase activity
A284_RS19295	COG2348	transferase activity, transferring amino-acyl groups
A284_RS19300	COG2348	transferase activity, transferring amino-acyl groups
A284_RS19320	COG0134	indole-3-glycerol-phosphate synthase activity
A284_RS19330	COG0512	Glutamine amidotransferase of anthranilate synthase
A284_RS19335	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A284_RS19340	COG1363	Peptidase, m42
A284_RS19345	COG0287	Prephenate dehydrogenase
A284_RS19350	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A284_RS19355	COG1942	4-Oxalocrotonate Tautomerase
A284_RS19370	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A284_RS19370	COG0392	lysyltransferase activity
A284_RS19375	COG0628	permease
A284_RS19380	COG3711	transcriptional antiterminator
A284_RS19385	COG1115	amino acid carrier protein
A284_RS19390	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A284_RS19395	COG0187	DNA topoisomerase II activity
A284_RS19410	COG0824	Thioesterase
A284_RS19415	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A284_RS19420	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A284_RS19425	COG1970	mechanosensitive ion channel activity
A284_RS19440	COG4846	Membrane protein involved in cytochrome C biogenesis
A284_RS19450	COG3763	UPF0154 protein
A284_RS19460	COG4224	UPF0291 protein
A284_RS19485	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A284_RS19500	COG0833	amino acid
A284_RS19515	COG0083	homoserine kinase activity
A284_RS19520	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A284_RS19525	COG0460	homoserine dehydrogenase
A284_RS19530	COG0527	aspartate kinase activity
A284_RS19545	COG1525	nuclease
A284_RS19555	COG2197	response regulator
A284_RS19570	COG1131	(ABC) transporter
A284_RS19610	COG0789	Transcriptional regulator
A284_RS19615	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
A284_RS19620	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A284_RS19625	COG0386	Belongs to the glutathione peroxidase family
A284_RS19630	COG1923	regulation of RNA biosynthetic process
A284_RS19635	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A284_RS19645	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A284_RS19655	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A284_RS19660	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
A284_RS19665	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A284_RS19680	COG4550	Control of competence regulator ComK, YlbF/YmcA
A284_RS19685	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A284_RS19695	COG4195	phage-related replication protein
A284_RS19700	COG1013	pyruvate-flavodoxin oxidoreductase activity
A284_RS19705	COG0674	pyruvate-flavodoxin oxidoreductase activity
A284_RS19705	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A284_RS19710	COG1692	metallophosphoesterase
A284_RS19720	COG1418	mRNA catabolic process
A284_RS19725	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A284_RS19730	COG1058	Belongs to the CinA family
A284_RS19730	COG1546	Belongs to the CinA family
A284_RS19740	COG1426	Protein conserved in bacteria
A284_RS19750	COG1028	Short-chain dehydrogenase reductase Sdr
A284_RS19755	COG0612	Peptidase, M16
A284_RS19760	COG0612	Peptidase, M16
A284_RS19765	COG2188	Transcriptional regulator
A284_RS19775	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A284_RS19780	COG1185	polyribonucleotide nucleotidyltransferase activity
A284_RS19785	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A284_RS19790	COG0196	riboflavin kinase activity
A284_RS19800	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A284_RS19805	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A284_RS19810	COG1358	cellular component organization or biogenesis
A284_RS19815	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A284_RS19820	COG0195	Participates in both transcription termination and antitermination
A284_RS19825	COG0779	Required for maturation of 30S ribosomal subunits
A284_RS19830	COG2176	DNA-directed DNA polymerase activity
A284_RS19835	COG0442	prolyl-tRNA aminoacylation
A284_RS19845	COG4589	Belongs to the CDS family
A284_RS19850	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A284_RS19855	COG0233	cytoplasmic translational termination
A284_RS19860	COG0528	UMP kinase activity
A284_RS19865	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A284_RS19870	COG0052	Belongs to the universal ribosomal protein uS2 family
A284_RS19885	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A284_RS19890	COG4974	Belongs to the 'phage' integrase family
A284_RS19895	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A284_RS19900	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A284_RS19905	COG0758	DNA mediated transformation
A284_RS19910	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A284_RS19915	COG0045	succinate-CoA ligase (ADP-forming) activity
A284_RS19920	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A284_RS19930	COG4485	Bacterial membrane protein, YfhO
A284_RS19945	COG0336	Belongs to the RNA methyltransferase TrmD family
A284_RS19950	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A284_RS19955	COG0228	four-way junction DNA binding
A284_RS19960	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A284_RS19965	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
A284_RS19970	COG0552	protein localization to endoplasmic reticulum
A284_RS19975	COG1196	nuclear chromosome segregation
A284_RS19980	COG0571	ribonuclease III activity
A284_RS19985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A284_RS20000	COG0416	fatty acid biosynthetic process
A284_RS20005	COG1349	DNA-binding transcription factor activity
A284_RS20010	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A284_RS20015	COG1461	Dihydroxyacetone kinase
A284_RS20020	COG1302	Protein conserved in bacteria
A284_RS20025	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A284_RS20035	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A284_RS20050	COG0631	protein serine/threonine phosphatase activity
A284_RS20055	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A284_RS20060	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A284_RS20060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A284_RS20065	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A284_RS20070	COG0242	peptide deformylase activity
A284_RS20080	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A284_RS20085	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A284_RS20090	COG1758	RNA polymerase activity
A284_RS20095	COG0194	GDP metabolic process
A284_RS20115	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A284_RS20120	COG0284	orotidine-5'-phosphate decarboxylase activity
A284_RS20125	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A284_RS20130	COG0505	Belongs to the CarA family
A284_RS20135	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A284_RS20140	COG0540	Belongs to the ATCase OTCase family
A284_RS20145	COG2233	PERMEase
A284_RS20150	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A284_RS20160	COG0564	pseudouridine synthase activity
A284_RS20170	COG1388	LysM domain
A284_RS20170	COG3942	CHAP domain
A284_RS20180	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A284_RS20185	COG3599	regulation of cell shape
A284_RS20195	COG0762	integral membrane protein
A284_RS20200	COG1799	cell septum assembly
A284_RS20205	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A284_RS20210	COG1496	oxidoreductase activity
A284_RS20215	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A284_RS20220	COG0849	cell division
A284_RS20225	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A284_RS20235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A284_RS20240	COG0768	penicillin binding
A284_RS20245	COG4839	cell division protein FtsL
A284_RS20250	COG0275	rRNA processing
A284_RS20260	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
A284_RS20270	COG1011	Hydrolase
A284_RS20305	COG3177	Filamentation induced by cAMP protein fic
A284_RS20310	COG1388	LysM domain
A284_RS20310	COG5632	N-Acetylmuramoyl-L-alanine amidase
A284_RS20350	COG5434	Belongs to the glycosyl hydrolase 28 family
A284_RS20375	COG5412	phage tail tape measure protein
A284_RS20375	COG3953	SLT domain
A284_RS20425	COG0740	serine-type endopeptidase activity
A284_RS20435	COG1802	Transcriptional regulator
A284_RS20435	COG4626	Terminase
A284_RS20455	COG3620	sequence-specific DNA binding
A284_RS20480	COG0756	dUTP diphosphatase activity
A284_RS20500	COG1525	nuclease
A284_RS20550	COG1484	DNA-dependent DNA replication
A284_RS20625	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A284_RS20635	COG0582	viral genome integration into host DNA
A284_RS20645	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A284_RS20650	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A284_RS20655	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A284_RS20660	COG1053	succinate dehydrogenase
A284_RS20665	COG2009	succinate dehydrogenase
A284_RS20670	COG0322	excinuclease ABC activity
A284_RS20675	COG3118	belongs to the thioredoxin family
A284_RS20680	COG1193	negative regulation of DNA recombination
A284_RS20685	COG1796	DNA polymerase
A284_RS20685	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A284_RS20695	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
A284_RS20700	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A284_RS20705	COG0072	phenylalanine-tRNA ligase activity
A284_RS20705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A284_RS20710	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A284_RS20715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A284_RS20720	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A284_RS20735	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A284_RS20740	COG0742	ribosomal rna small subunit methyltransferase
A284_RS20755	COG0584	glycerophosphoryl diester phosphodiesterase
A284_RS20765	COG3679	Belongs to the UPF0342 family
A284_RS20780	COG0109	protoheme IX farnesyltransferase activity
A284_RS20785	COG1612	heme a metabolic process
A284_RS20795	COG0772	Belongs to the SEDS family
A284_RS20800	COG4838	Belongs to the UPF0358 family
A284_RS20805	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A284_RS20810	COG4896	Protein conserved in bacteria
A284_RS20815	COG1217	gtp-binding protein TYPA
A284_RS20825	COG0483	inositol monophosphate 1-phosphatase activity
A284_RS20830	COG4493	Belongs to the UPF0637 family
A284_RS20860	COG1176	ABC-type spermidine putrescine transport system, permease component I
A284_RS20875	COG4476	Belongs to the UPF0223 family
A284_RS20885	COG0508	dehydrogenase complex catalyzes the overall conversion of
A284_RS20905	COG0242	peptide deformylase activity
A284_RS20910	COG5503	Protein of unknown function (DUF1447)
A284_RS20915	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A284_RS20920	COG0569	domain protein
A284_RS20925	COG1294	oxidase, subunit
A284_RS20930	COG1271	oxidase subunit
A284_RS20940	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A284_RS20945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A284_RS20955	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A284_RS20970	COG4172	Belongs to the ABC transporter superfamily
A284_RS20975	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A284_RS20980	COG0151	Belongs to the GarS family
A284_RS20985	COG0138	bifunctional purine biosynthesis protein purh
A284_RS20995	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A284_RS21010	COG0047	phosphoribosylformylglycinamidine synthase activity
A284_RS21015	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A284_RS21020	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A284_RS21030	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A284_RS21035	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A284_RS21040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A284_RS21040	COG1017	nitric oxide dioxygenase activity
A284_RS21050	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A284_RS21065	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A284_RS21080	COG1316	TRANSCRIPTIONal
A284_RS21105	COG3594	Acyltransferase
A284_RS21110	COG0436	Aminotransferase
A284_RS21115	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A284_RS21125	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A284_RS21130	COG1169	isochorismate synthase
A284_RS21135	COG1575	Belongs to the MenA family. Type 1 subfamily
A284_RS21140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A284_RS21145	COG2314	TM2 domain
A284_RS21180	COG4873	Protein conserved in bacteria
A284_RS21195	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A284_RS21200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A284_RS21205	COG0861	Integral membrane protein TerC family
A284_RS21210	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A284_RS21220	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A284_RS21225	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A284_RS21230	COG2814	Major facilitator Superfamily
A284_RS21235	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A284_RS21240	COG2382	esterase
A284_RS21245	COG1115	amino acid carrier protein
A284_RS21250	COG0628	permease
A284_RS21260	COG0569	domain protein
A284_RS21260	COG0475	glutathione-regulated potassium exporter activity
A284_RS21265	COG2239	Acts as a magnesium transporter
A284_RS21270	COG0564	pseudouridine synthase activity
A284_RS21275	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A284_RS21280	COG2357	RelA SpoT domain protein
A284_RS21295	COG2346	COG2346, Truncated hemoglobins
A284_RS21300	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A284_RS21305	COG1164	Oligoendopeptidase f
A284_RS21315	COG4862	establishment of competence for transformation
A284_RS21320	COG1393	Belongs to the ArsC family
A284_RS21325	COG0180	Tryptophanyl-tRNA synthetase
A284_RS21335	COG4608	Belongs to the ABC transporter superfamily
A284_RS21340	COG0444	Belongs to the ABC transporter superfamily
A284_RS21345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A284_RS21350	COG0601	transmembrane transport
A284_RS21365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A284_RS21375	COG0542	response to heat
A284_RS21390	COG0561	phosphatase activity
A284_RS21395	COG0446	pyridine nucleotide-disulphide oxidoreductase
A284_RS21410	COG1074	ATP-dependent DNA helicase activity
A284_RS21430	COG0398	Pfam SNARE associated Golgi protein
A284_RS21440	COG0137	argininosuccinate synthase activity
A284_RS21445	COG0165	Argininosuccinate lyase
A284_RS21450	COG0584	glycerophosphoryl diester phosphodiesterase
A284_RS21455	COG0584	glycerophosphoryl diester phosphodiesterase
A284_RS21475	COG1902	pentaerythritol trinitrate reductase activity
A284_RS21480	COG1098	S1 RNA binding domain
A284_RS21495	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A284_RS21495	COG2111	Na H antiporter
A284_RS21500	COG2111	Na H antiporter
A284_RS21505	COG1006	Multisubunit Na H antiporter MnhC subunit
A284_RS21510	COG0651	ATP synthesis coupled electron transport
A284_RS21520	COG2212	antiporter activity
A284_RS21540	COG2050	protein possibly involved in aromatic compounds catabolism
A284_RS21545	COG2056	Na+-H+ antiporter family
A284_RS21550	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A284_RS21560	COG0316	Belongs to the HesB IscA family
A284_RS21565	COG4844	belongs to the
A284_RS21570	COG1252	NADH dehydrogenase
A284_RS21575	COG4837	Protein of unknown function (DUF1462)
A284_RS21580	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A284_RS21585	COG0583	DNA-binding transcription factor activity
A284_RS21595	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A284_RS21605	COG1696	Membrane protein involved in D-alanine export
A284_RS21610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A284_RS21630	COG2445	Protein of unknown function DUF86
A284_RS21640	COG4470	Protein conserved in bacteria
A284_RS21645	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A284_RS21650	COG0737	Belongs to the 5'-nucleotidase family
A284_RS21655	COG0730	response to heat
A284_RS21660	COG1801	Protein of unknown function DUF72
A284_RS21665	COG2070	2-Nitropropane dioxygenase
A284_RS21670	COG1253	flavin adenine dinucleotide binding
A284_RS21675	COG0719	Fe-S assembly protein
A284_RS21680	COG0822	iron-sulfur transferase activity
A284_RS21685	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A284_RS21690	COG0719	Fe-S assembly protein
A284_RS21695	COG0396	ATPase activity
A284_RS21705	COG1464	Belongs to the NlpA lipoprotein family
A284_RS21710	COG2011	ABC-type metal ion transport system permease component
A284_RS21715	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A284_RS21725	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A284_RS21730	COG0509	glycine decarboxylation via glycine cleavage system
A284_RS21735	COG1393	Belongs to the ArsC family
A284_RS21740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A284_RS21750	COG0710	3-dehydroquinate dehydratase activity
A284_RS21755	COG1764	response to oxidative stress
A284_RS21770	COG0406	alpha-ribazole phosphatase activity
A284_RS21805	COG4195	phage-related replication protein
A284_RS21830	COG1278	Cold shock
A284_RS21855	COG0656	L-ascorbic acid biosynthetic process
A284_RS21860	COG1309	transcriptional regulator
A284_RS21905	COG5484	DNA packaging
A284_RS21905	COG3728	DNA packaging
A284_RS21930	COG0557	exoribonuclease II activity
A284_RS21935	COG1647	Serine aminopeptidase, S33
A284_RS21940	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A284_RS21950	COG0148	phosphopyruvate hydratase activity
A284_RS21955	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A284_RS21960	COG0149	triose-phosphate isomerase activity
A284_RS21965	COG0126	phosphoglycerate kinase activity
A284_RS21975	COG2390	Transcriptional regulator
A284_RS22000	COG0740	serine-type endopeptidase activity
A284_RS22010	COG1481	regulation of sporulation
A284_RS22015	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A284_RS22020	COG1660	Displays ATPase and GTPase activities
A284_RS22025	COG0492	ferredoxin-NADP+ reductase activity
A284_RS22040	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A284_RS22050	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A284_RS22055	COG0556	nucleotide-excision repair
A284_RS22070	COG1388	LysM domain
A284_RS22070	COG3942	CHAP domain
A284_RS22075	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A284_RS22080	COG0653	protein targeting
A284_RS22085	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A284_RS22090	COG1040	competence protein
A284_RS22095	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A284_RS22105	COG1739	Uncharacterized protein family UPF0029
A284_RS22110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A284_RS22130	COG2195	Cleaves the N-terminal amino acid of tripeptides
A284_RS22135	COG1929	Belongs to the glycerate kinase type-1 family
A284_RS22155	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A284_RS22170	COG4604	ABC transporter, ATP-binding protein
A284_RS22175	COG4605	iron ion homeostasis
A284_RS22180	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A284_RS22185	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A284_RS22190	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A284_RS22195	COG1780	Probably involved in ribonucleotide reductase function
A284_RS22210	COG3104	oligopeptide transport
A284_RS22215	COG1597	lipid kinase activity
A284_RS22225	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A284_RS22230	COG1174	glycine betaine transport
A284_RS22235	COG0517	IMP dehydrogenase activity
A284_RS22235	COG1125	glycine betaine transport
A284_RS22240	COG0514	ATP-dependent DNA helicase (RecQ)
A284_RS22245	COG0488	(ABC) transporter
A284_RS22260	COG1368	sulfuric ester hydrolase activity
A284_RS22290	COG0512	Glutamine amidotransferase of anthranilate synthase
A284_RS22290	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A284_RS22295	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A284_RS22300	COG0720	synthase
A284_RS22305	COG0602	queuosine metabolic process
A284_RS22315	COG0463	Glycosyl transferase, family 2
A284_RS22320	COG0656	L-ascorbic acid biosynthetic process
A284_RS22325	COG1253	flavin adenine dinucleotide binding
A284_RS22330	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A284_RS22335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A284_RS22335	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A284_RS22335	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A284_RS22340	COG1105	Belongs to the carbohydrate kinase PfkB family
A284_RS22345	COG1349	DNA-binding transcription factor activity
A284_RS22350	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A284_RS22375	COG0415	Belongs to the DNA photolyase family
A284_RS22385	COG0471	metal ion transport
A284_RS22390	COG0039	L-malate dehydrogenase activity
A284_RS22400	COG4989	oxidoreductase activity
A284_RS22405	COG0523	cobalamin synthesis protein
A284_RS22415	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A284_RS22420	COG4988	ABC transporter
A284_RS22425	COG1968	undecaprenyl-diphosphatase activity
A284_RS22435	COG1671	Belongs to the UPF0178 family
A284_RS22440	COG1611	Belongs to the LOG family
A284_RS22450	COG1959	2 iron, 2 sulfur cluster binding
A284_RS22460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A284_RS22485	COG2839	Protein conserved in bacteria
A284_RS22490	COG2814	Major facilitator Superfamily
A284_RS22495	COG0583	DNA-binding transcription factor activity
A284_RS22510	COG0217	transcriptional regulatory protein
A284_RS22520	COG2207	Transcriptional regulator
A284_RS22520	COG0662	Cupin 2, conserved barrel domain protein
A284_RS22530	COG1388	LysM domain
A284_RS22530	COG3942	CHAP domain
A284_RS22540	COG0306	phosphate transporter
A284_RS22545	COG1392	Phosphate transport regulator
A284_RS22555	COG0577	efflux transmembrane transporter activity
A284_RS22560	COG1136	(ABC) transporter
A284_RS22565	COG2205	protein histidine kinase activity
A284_RS22575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A284_RS22585	COG0657	acetylesterase activity
A284_RS22590	COG3949	Membrane
A284_RS22600	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
A284_RS22610	COG2376	Dihydroxyacetone kinase
A284_RS22615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A284_RS22620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A284_RS22625	COG1120	ATPase activity
A284_RS22630	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A284_RS22635	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A284_RS22640	COG1132	(ABC) transporter
A284_RS22645	COG1686	Belongs to the peptidase S11 family
A284_RS22650	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A284_RS22660	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A284_RS22665	COG1682	transport, permease protein
A284_RS22670	COG1134	teichoic acid transport
A284_RS22675	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A284_RS22690	COG1121	(ABC) transporter
A284_RS22695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A284_RS22700	COG0803	Belongs to the bacterial solute-binding protein 9 family
A284_RS22710	COG1320	monovalent cation:proton antiporter activity
A284_RS22720	COG1863	multisubunit Na H antiporter MnhE subunit
A284_RS22725	COG0651	ATP synthesis coupled electron transport
A284_RS22730	COG1006	Multisubunit Na H antiporter MnhC subunit
A284_RS22735	COG2111	Na H antiporter
A284_RS22740	COG2111	Na H antiporter
A284_RS22740	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A284_RS22775	COG2267	carboxylic ester hydrolase activity
A284_RS22795	COG0546	phosphoglycolate phosphatase activity
A284_RS22800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A284_RS22805	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A284_RS22810	COG0534	Mate efflux family protein
A284_RS22820	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A284_RS22825	COG0018	arginyl-trna synthetase
A284_RS22850	COG1078	dGTPase activity
A284_RS22860	COG0655	NAD(P)H dehydrogenase (quinone) activity
A284_RS22865	COG0667	Aldo Keto reductase
A284_RS22870	COG4844	belongs to the
A284_RS22885	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A284_RS22890	COG0095	Lipoate-protein ligase
A284_RS22895	COG0280	phosphate acetyltransferase
A284_RS22900	COG3253	May function as heme-dependent peroxidase
A284_RS22920	COG2363	Small membrane protein
A284_RS22935	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
A284_RS22960	COG0477	Major facilitator Superfamily
A284_RS22975	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A284_RS22980	COG0363	glucosamine-6-phosphate deaminase activity
A284_RS22990	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A284_RS22995	COG1469	GTP cyclohydrolase I activity
A284_RS23000	COG2271	Major facilitator Superfamily
A284_RS23025	COG0431	NADPH-dependent FMN reductase
A284_RS23030	COG0561	phosphatase activity
A284_RS23040	COG1428	Deoxynucleoside kinase
A284_RS23045	COG1428	Deoxynucleoside kinase
A284_RS23050	COG0546	phosphoglycolate phosphatase activity
A284_RS23055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A284_RS23080	COG1063	alcohol dehydrogenase
A284_RS23085	COG2814	Major facilitator Superfamily
A284_RS23090	COG1349	DNA-binding transcription factor activity
A284_RS23115	COG1473	amidohydrolase
A284_RS23125	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A284_RS23130	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A284_RS23135	COG0049	tRNA binding
A284_RS23140	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A284_RS23150	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A284_RS23155	COG0085	RNA polymerase activity
A284_RS23160	COG2813	Specifically methylates the guanine in position
A284_RS23165	COG0222	ribosome binding
A284_RS23170	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A284_RS23175	COG0081	regulation of translation
A284_RS23180	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A284_RS23185	COG0250	Participates in transcription elongation, termination and antitermination
A284_RS23200	COG3688	RNA-binding protein containing a PIN domain
A284_RS23210	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
A284_RS23215	COG0215	cysteine-tRNA ligase activity
A284_RS23225	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A284_RS23230	COG4956	integral membrane protein (PIN domain superfamily)
A284_RS23235	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A284_RS23240	COG0542	response to heat
A284_RS23245	COG3869	Catalyzes the specific phosphorylation of arginine residues in
A284_RS23250	COG3880	PFAM UvrB UvrC protein
A284_RS23260	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A284_RS23265	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
A284_RS23270	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
A284_RS23275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A284_RS23340	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A284_RS23345	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A284_RS23350	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A284_RS23370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A284_RS23385	COG1098	S1 RNA binding domain
A284_RS23395	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A284_RS23400	COG3956	TIGRFAM MazG family protein
A284_RS23405	COG2244	polysaccharide biosynthetic process
A284_RS23410	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A284_RS23415	COG0193	aminoacyl-tRNA hydrolase activity
A284_RS23420	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A284_RS23425	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A284_RS23430	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A284_RS23435	COG2088	sporulation resulting in formation of a cellular spore
A284_RS23440	COG0251	oxidation-reduction process
A284_RS23445	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A284_RS23450	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A284_RS23455	COG4466	Protein conserved in bacteria
A284_RS23460	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A284_RS23465	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A284_RS23470	COG0084	hydrolase, TatD family'
A284_RS23475	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A284_RS23475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A284_RS23480	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A284_RS23485	COG2827	Endonuclease containing a URI domain
A284_RS23490	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A284_RS23495	COG4467	Involved in initiation control of chromosome replication
A284_RS23500	COG1774	PSP1 C-terminal conserved region
A284_RS23505	COG0470	DNA polymerase III
A284_RS23510	COG3870	Protein conserved in bacteria
A284_RS23520	COG1982	Orn Lys Arg decarboxylase major
A284_RS23525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A284_RS23545	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A284_RS23550	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A284_RS23555	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A284_RS23565	COG2188	Transcriptional regulator
A284_RS23570	COG0366	Alpha amylase catalytic
A284_RS23575	COG1263	PTS System
A284_RS23575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A284_RS23585	COG0493	'glutamate synthase
A284_RS23590	COG0069	glutamate synthase activity
A284_RS23590	COG0067	glutamate synthase
A284_RS23590	COG0070	glutamate synthase
A284_RS23610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A284_RS23615	COG0494	nUDIX hydrolase
A284_RS23625	COG0438	transferase activity, transferring glycosyl groups
A284_RS23640	COG1278	Cold shock
A284_RS23645	COG3759	membrane
A284_RS23680	COG1846	Transcriptional regulator
A284_RS23690	COG0626	cystathionine gamma-synthase activity
A284_RS23695	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A284_RS23710	COG1279	arginine transmembrane transporter activity
A284_RS23715	COG0733	neurotransmitter:sodium symporter activity
A284_RS23725	COG1647	Serine aminopeptidase, S33
A284_RS23730	COG0671	phosphoesterase, PA-phosphatase related
A284_RS23745	COG5609	conserved protein (DUF2294)
A284_RS23750	COG3002	Belongs to the UPF0753 family
A284_RS23755	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A284_RS23770	COG0523	cobalamin synthesis protein
A284_RS23780	COG0519	Catalyzes the synthesis of GMP from XMP
A284_RS23780	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A284_RS23785	COG0516	GMP reductase activity
A284_RS23785	COG0517	IMP dehydrogenase activity
A284_RS23790	COG2233	PERMEase
A284_RS23795	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A284_RS23810	COG5183	chlorophyll binding
A284_RS23815	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A284_RS23820	COG1823	symporter activity
A284_RS23825	COG0778	Nitroreductase
A284_RS23830	COG0450	alkyl hydroperoxide reductase
A284_RS23835	COG3634	alkyl hydroperoxide reductase activity
A284_RS23860	COG1280	lysine exporter protein (LysE YggA)
A284_RS23885	COG3728	DNA packaging
A284_RS23885	COG5484	DNA packaging
A284_RS23960	COG0582	viral genome integration into host DNA
A284_RS23975	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A284_RS23985	COG0360	Binds together with S18 to 16S ribosomal RNA
A284_RS24000	COG0012	GTP binding
A284_RS24005	COG4481	Protein conserved in bacteria
A284_RS24010	COG0668	transmembrane transport
A284_RS24015	COG1475	DNA binding
A284_RS24020	COG0626	cystathionine gamma-synthase activity
A284_RS24025	COG0626	cystathionine gamma-synthase activity
A284_RS24030	COG0646	methionine synthase
A284_RS24030	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A284_RS24035	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A284_RS24055	COG3942	CHAP domain
A284_RS24070	COG0183	Belongs to the thiolase family
A284_RS24075	COG3250	beta-galactosidase activity
A284_RS24080	COG1028	Short-chain dehydrogenase reductase Sdr
A284_RS24085	COG1312	Catalyzes the dehydration of D-mannonate
A284_RS24090	COG1904	glucuronate isomerase
A284_RS24095	COG2211	Major facilitator Superfamily
A284_RS24100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A284_RS24105	COG0800	Aldolase
A284_RS24110	COG2207	Transcriptional regulator
A284_RS24155	COG1476	TRANSCRIPTIONal
A284_RS24165	COG1131	(ABC) transporter
A284_RS24180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A284_RS24200	COG1136	(ABC) transporter
A284_RS24205	COG0577	efflux transmembrane transporter activity
A284_RS24285	COG2348	transferase activity, transferring amino-acyl groups
A284_RS24295	COG1063	alcohol dehydrogenase
A284_RS24300	COG0577	efflux transmembrane transporter activity
A284_RS24305	COG1136	(ABC) transporter
A284_RS24345	COG1475	DNA binding
A284_RS24350	COG0357	Ribosomal RNA small subunit methyltransferase G
A284_RS24355	COG0445	tRNA wobble uridine modification
A284_RS24360	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A284_RS24365	COG0594	ribonuclease P activity
A284_RS24400	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A284_RS24405	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A284_RS24515	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A284_RS24655	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A284_RS24660	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A284_RS24675	COG0592	DNA-directed DNA polymerase activity
A284_RS24720	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A284_RS24810	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A284_RS24835	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids