locus-tag	class	description
EAH52_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EAH52_RS00010	COG0592	DNA-directed DNA polymerase activity
EAH52_RS00015	COG2501	S4 domain
EAH52_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EAH52_RS00025	COG0187	DNA topoisomerase II activity
EAH52_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EAH52_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EAH52_RS00050	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
EAH52_RS00060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EAH52_RS00075	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
EAH52_RS00080	COG0359	binds to the 23S rRNA
EAH52_RS00085	COG0305	Participates in initiation and elongation during chromosome replication
EAH52_RS00105	COG0745	RESPONSE REGULATOR receiver
EAH52_RS00110	COG5002	protein histidine kinase activity
EAH52_RS00115	COG4863	YycH protein
EAH52_RS00125	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EAH52_RS00135	COG1401	restriction endodeoxyribonuclease activity
EAH52_RS00170	COG3223	Belongs to the PsiE family
EAH52_RS00180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EAH52_RS00185	COG1733	regulation of RNA biosynthetic process
EAH52_RS00230	COG2851	Citrate transporter
EAH52_RS00235	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EAH52_RS00240	COG2814	Major facilitator Superfamily
EAH52_RS00245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EAH52_RS00250	COG2226	methyltransferase
EAH52_RS00255	COG5564	TIM-barrel signal transduction protein
EAH52_RS00265	COG5564	TIM-barrel signal transduction protein
EAH52_RS00290	COG2808	Putative FMN-binding domain
EAH52_RS00295	COG0110	maltose O-acetyltransferase activity
EAH52_RS00300	COG1114	Component of the transport system for branched-chain amino acids
EAH52_RS00305	COG2814	Major facilitator Superfamily
EAH52_RS00350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EAH52_RS00355	COG1609	Transcriptional regulator
EAH52_RS00365	COG1869	D-ribose catabolic process
EAH52_RS00385	COG2814	Major facilitator Superfamily
EAH52_RS00405	COG1131	(ABC) transporter
EAH52_RS00435	COG0601	transmembrane transport
EAH52_RS00445	COG0444	Belongs to the ABC transporter superfamily
EAH52_RS00450	COG1124	(ABC) transporter
EAH52_RS00465	COG0346	lactoylglutathione lyase activity
EAH52_RS00475	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EAH52_RS00525	COG1250	3-hydroxyacyl-CoA dehydrogenase
EAH52_RS00530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EAH52_RS00550	COG2235	arginine
EAH52_RS00555	COG1438	arginine binding
EAH52_RS00560	COG0659	secondary active sulfate transmembrane transporter activity
EAH52_RS00580	COG2814	Major facilitator Superfamily
EAH52_RS00605	COG0438	transferase activity, transferring glycosyl groups
EAH52_RS00610	COG0653	protein targeting
EAH52_RS00620	COG1073	alpha beta
EAH52_RS00630	COG0201	protein transport
EAH52_RS00645	COG0747	negative chemotaxis
EAH52_RS00650	COG0601	transmembrane transport
EAH52_RS00655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EAH52_RS00665	COG1124	(ABC) transporter
EAH52_RS00670	COG0789	Transcriptional regulator
EAH52_RS00675	COG0656	L-ascorbic acid biosynthetic process
EAH52_RS00690	COG2259	Doxx family
EAH52_RS00700	COG1959	2 iron, 2 sulfur cluster binding
EAH52_RS00705	COG2910	NAD(P)H-binding
EAH52_RS00710	COG1876	peptidase activity
EAH52_RS00715	COG1882	Formate acetyltransferase
EAH52_RS00720	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EAH52_RS00730	COG1288	antiporter activity
EAH52_RS00735	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EAH52_RS00740	COG0463	Glycosyl transferase, family 2
EAH52_RS00740	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EAH52_RS00755	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EAH52_RS00805	COG1785	Belongs to the alkaline phosphatase family
EAH52_RS00840	COG0745	RESPONSE REGULATOR receiver
EAH52_RS00845	COG1131	(ABC) transporter
EAH52_RS00855	COG2205	protein histidine kinase activity
EAH52_RS00865	COG2720	vancomycin resistance protein
EAH52_RS00870	COG1136	(ABC) transporter
EAH52_RS00885	COG4221	oxidoreductase activity
EAH52_RS00890	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
EAH52_RS00895	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
EAH52_RS00900	COG2962	Rard protein
EAH52_RS00905	COG0471	metal ion transport
EAH52_RS00915	COG1695	Transcriptional regulator
EAH52_RS00930	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EAH52_RS00935	COG1054	Belongs to the UPF0176 family
EAH52_RS00960	COG1288	antiporter activity
EAH52_RS00965	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EAH52_RS00970	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
EAH52_RS00985	COG2814	Major facilitator Superfamily
EAH52_RS00990	COG0737	Belongs to the 5'-nucleotidase family
EAH52_RS01005	COG3639	organic phosphonate transmembrane transporter activity
EAH52_RS01065	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EAH52_RS01085	COG2113	Glycine betaine
EAH52_RS01090	COG2409	Drug exporters of the RND superfamily
EAH52_RS01095	COG1764	response to oxidative stress
EAH52_RS01105	COG1705	Flagellar rod assembly protein muramidase FlgJ
EAH52_RS01105	COG3942	CHAP domain
EAH52_RS01125	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EAH52_RS01135	COG0739	heme binding
EAH52_RS01140	COG3227	Zinc metalloprotease (Elastase)
EAH52_RS01145	COG2843	Capsule synthesis protein
EAH52_RS01160	COG3961	Belongs to the TPP enzyme family
EAH52_RS01170	COG4195	phage-related replication protein
EAH52_RS01185	COG0745	RESPONSE REGULATOR receiver
EAH52_RS01190	COG2205	protein histidine kinase activity
EAH52_RS01195	COG1136	(ABC) transporter
EAH52_RS01225	COG0175	sulfate reduction
EAH52_RS01230	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EAH52_RS01235	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EAH52_RS01250	COG0730	response to heat
EAH52_RS01255	COG2046	Belongs to the sulfate adenylyltransferase family
EAH52_RS01260	COG0529	Catalyzes the synthesis of activated sulfate
EAH52_RS01270	COG3942	CHAP domain
EAH52_RS01275	COG1328	CTP reductase activity
EAH52_RS01280	COG0602	queuosine metabolic process
EAH52_RS01285	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EAH52_RS01295	COG1510	regulation of RNA biosynthetic process
EAH52_RS01300	COG1012	belongs to the aldehyde dehydrogenase family
EAH52_RS01305	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
EAH52_RS01310	COG1473	amidohydrolase
EAH52_RS01330	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EAH52_RS01335	COG0574	Belongs to the PEP-utilizing enzyme family
EAH52_RS01335	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EAH52_RS01340	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EAH52_RS01345	COG0579	oxidoreductase
EAH52_RS01350	COG2723	6-phospho-beta-galactosidase activity
EAH52_RS01360	COG1695	Transcriptional regulator
EAH52_RS01370	COG3588	fructose-bisphosphate aldolase
EAH52_RS01375	COG0563	adenylate kinase activity
EAH52_RS01385	COG0446	pyridine nucleotide-disulphide oxidoreductase
EAH52_RS01410	COG0531	amino acid
EAH52_RS01420	COG0583	DNA-binding transcription factor activity
EAH52_RS01425	COG0039	L-malate dehydrogenase activity
EAH52_RS01430	COG0028	Belongs to the TPP enzyme family
EAH52_RS01435	COG3527	Alpha-acetolactate decarboxylase
EAH52_RS01445	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EAH52_RS01450	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EAH52_RS01465	COG4640	response to antibiotic
EAH52_RS01495	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EAH52_RS01505	COG0167	dihydroorotate dehydrogenase activity
EAH52_RS01510	COG3001	Fructosamine kinase
EAH52_RS01515	COG0596	Alpha beta hydrolase
EAH52_RS01525	COG4221	oxidoreductase activity
EAH52_RS01560	COG1113	amino acid transport
EAH52_RS01575	COG1388	LysM domain
EAH52_RS01590	COG0436	Aminotransferase
EAH52_RS01600	COG2608	mercury ion transmembrane transporter activity
EAH52_RS01615	COG1028	Short-chain dehydrogenase reductase Sdr
EAH52_RS01625	COG1012	belongs to the aldehyde dehydrogenase family
EAH52_RS01655	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EAH52_RS01660	COG3425	synthase
EAH52_RS01670	COG1388	LysM domain
EAH52_RS01670	COG3942	CHAP domain
EAH52_RS01680	COG0583	DNA-binding transcription factor activity
EAH52_RS01685	COG1380	Effector of murein hydrolase LrgA
EAH52_RS01690	COG1346	cytolysis
EAH52_RS01695	COG0028	Belongs to the TPP enzyme family
EAH52_RS01720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EAH52_RS01725	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EAH52_RS01730	COG0657	acetylesterase activity
EAH52_RS01740	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EAH52_RS01750	COG2843	Capsule synthesis protein
EAH52_RS01770	COG1070	Carbohydrate kinase
EAH52_RS01780	COG1760	l-serine dehydratase
EAH52_RS01785	COG1760	l-serine dehydratase
EAH52_RS01800	COG3764	Sortase (surface protein transpeptidase)
EAH52_RS01805	COG0561	phosphatase activity
EAH52_RS01815	COG0778	Nitroreductase
EAH52_RS01820	COG1012	belongs to the aldehyde dehydrogenase family
EAH52_RS01840	COG2314	TM2 domain
EAH52_RS01845	COG2514	catechol 2,3-dioxygenase activity
EAH52_RS01860	COG0583	DNA-binding transcription factor activity
EAH52_RS01865	COG1012	belongs to the aldehyde dehydrogenase family
EAH52_RS01870	COG3949	Membrane
EAH52_RS01880	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
EAH52_RS01885	COG0586	Pfam SNARE associated Golgi protein
EAH52_RS01890	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EAH52_RS01895	COG2022	thiamine diphosphate biosynthetic process
EAH52_RS01910	COG0352	thiamine-phosphate diphosphorylase activity
EAH52_RS01915	COG2271	Major facilitator Superfamily
EAH52_RS01920	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
EAH52_RS01930	COG4876	unkown
EAH52_RS01935	COG2357	RelA SpoT domain protein
EAH52_RS01945	COG1802	Transcriptional regulator
EAH52_RS01950	COG1070	Carbohydrate kinase
EAH52_RS01955	COG2610	gluconate transmembrane transporter activity
EAH52_RS01960	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EAH52_RS01975	COG1215	transferase activity, transferring glycosyl groups
EAH52_RS01980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EAH52_RS01985	COG0494	nUDIX hydrolase
EAH52_RS01995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EAH52_RS02000	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EAH52_RS02005	COG0022	dehydrogenase e1 component
EAH52_RS02010	COG0508	dehydrogenase complex catalyzes the overall conversion of
EAH52_RS02040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EAH52_RS02045	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EAH52_RS02055	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
EAH52_RS02060	COG1028	Short-chain dehydrogenase reductase Sdr
EAH52_RS02065	COG1363	Peptidase, m42
EAH52_RS02070	COG4808	Protein conserved in bacteria
EAH52_RS02090	COG0069	glutamate synthase activity
EAH52_RS02105	COG4619	ABC transporter
EAH52_RS02110	COG0390	transport system, permease component
EAH52_RS02115	COG2814	Major facilitator Superfamily
EAH52_RS02120	COG2272	Belongs to the type-B carboxylesterase lipase family
EAH52_RS02125	COG0531	amino acid
EAH52_RS02130	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
EAH52_RS02155	COG1174	glycine betaine transport
EAH52_RS02160	COG1346	cytolysis
EAH52_RS02165	COG1380	Effector of murein hydrolase LrgA
EAH52_RS02175	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EAH52_RS02185	COG3477	response to acidic pH
EAH52_RS02195	COG0706	membrane insertase activity
EAH52_RS02205	COG0531	amino acid
EAH52_RS02215	COG1113	amino acid transport
EAH52_RS02220	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EAH52_RS02235	COG2814	Major facilitator Superfamily
EAH52_RS02240	COG1695	Transcriptional regulator
EAH52_RS02255	COG1929	Belongs to the glycerate kinase type-1 family
EAH52_RS02270	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EAH52_RS02275	COG0741	lytic transglycosylase activity
EAH52_RS02280	COG0588	phosphoglycerate mutase activity
EAH52_RS02290	COG2814	Major facilitator Superfamily
EAH52_RS02295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EAH52_RS02300	COG0765	amino acid transport
EAH52_RS02305	COG1126	abc transporter atp-binding protein
EAH52_RS02310	COG2348	transferase activity, transferring amino-acyl groups
EAH52_RS02325	COG0803	Belongs to the bacterial solute-binding protein 9 family
EAH52_RS02345	COG0454	-acetyltransferase
EAH52_RS02350	COG0747	negative chemotaxis
EAH52_RS02360	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EAH52_RS02365	COG2146	nitrite reductase [NAD(P)H] activity
EAH52_RS02375	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EAH52_RS02380	COG1140	nitrate reductase beta subunit
EAH52_RS02390	COG2181	nitrate reductase activity
EAH52_RS02410	COG2223	nitrite transmembrane transporter activity
EAH52_RS02425	COG0778	Nitroreductase
EAH52_RS02435	COG1301	dicarboxylic acid transport
EAH52_RS02460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EAH52_RS02460	COG1263	PTS System
EAH52_RS02485	COG1028	Short-chain dehydrogenase reductase Sdr
EAH52_RS02490	COG0583	DNA-binding transcription factor activity
EAH52_RS02500	COG1028	Short-chain dehydrogenase reductase Sdr
EAH52_RS02530	COG0492	ferredoxin-NADP+ reductase activity
EAH52_RS02535	COG0456	acetyltransferase
EAH52_RS02540	COG0604	alcohol dehydrogenase
EAH52_RS02545	COG2822	iron ion transport
EAH52_RS02550	COG2837	iron assimilation
EAH52_RS02555	COG0672	)-iron permease
EAH52_RS02560	COG0805	protein transport
EAH52_RS02565	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EAH52_RS02575	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EAH52_RS02575	COG0463	Glycosyl transferase, family 2
EAH52_RS02585	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EAH52_RS02585	COG0463	Glycosyl transferase, family 2
EAH52_RS02590	COG1620	l-lactate permease
EAH52_RS02600	COG0579	oxidoreductase
EAH52_RS02650	COG2814	Major facilitator Superfamily
EAH52_RS02660	COG1566	PFAM secretion protein HlyD family protein
EAH52_RS02665	COG2814	Major facilitator Superfamily
EAH52_RS02695	COG1304	FMN binding
EAH52_RS02700	COG0786	glutamate:sodium symporter activity
EAH52_RS02705	COG1695	Transcriptional regulator
EAH52_RS02720	COG2094	Belongs to the DNA glycosylase MPG family
EAH52_RS02730	COG1069	ribulokinase activity
EAH52_RS02740	COG1668	transmembrane transport
EAH52_RS02745	COG1742	UPF0060 membrane protein
EAH52_RS02750	COG2017	converts alpha-aldose to the beta-anomer
EAH52_RS02755	COG2258	MOSC domain
EAH52_RS02760	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EAH52_RS02770	COG1266	CAAX protease self-immunity
EAH52_RS02775	COG0010	Belongs to the arginase family
EAH52_RS02780	COG0583	DNA-binding transcription factor activity
EAH52_RS02795	COG1473	amidohydrolase
EAH52_RS02800	COG1028	Short-chain dehydrogenase reductase Sdr
EAH52_RS02820	COG1737	Transcriptional regulator
EAH52_RS02825	COG1263	PTS System
EAH52_RS02825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EAH52_RS02835	COG0385	Bile acid
EAH52_RS02840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EAH52_RS02860	COG1113	amino acid transport
EAH52_RS02870	COG1263	PTS System
EAH52_RS02870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EAH52_RS02875	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EAH52_RS02890	COG1266	CAAX protease self-immunity
EAH52_RS02895	COG2378	regulation of single-species biofilm formation
EAH52_RS02900	COG0483	inositol monophosphate 1-phosphatase activity
EAH52_RS02905	COG1316	TRANSCRIPTIONal
EAH52_RS02935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EAH52_RS02940	COG2076	Multidrug Resistance protein
EAH52_RS02945	COG2076	Multidrug Resistance protein
EAH52_RS02950	COG3942	CHAP domain
EAH52_RS02965	COG1757	Na H antiporter
EAH52_RS02970	COG3942	CHAP domain
EAH52_RS02980	COG1846	Transcriptional regulator
EAH52_RS02995	COG0829	nickel cation binding
EAH52_RS03015	COG0804	urea catabolic process
EAH52_RS03025	COG0831	urea catabolic process
EAH52_RS03030	COG4413	Urea transporter
EAH52_RS03035	COG0765	amino acid transport
EAH52_RS03040	COG0765	amino acid transport
EAH52_RS03045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EAH52_RS03050	COG1126	abc transporter atp-binding protein
EAH52_RS03055	COG1960	acyl-CoA dehydrogenase activity
EAH52_RS03070	COG1268	BioY protein
EAH52_RS03080	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EAH52_RS03085	COG0725	ABC transporter, periplasmic molybdate-binding protein
EAH52_RS03090	COG4149	molybdate abc transporter
EAH52_RS03095	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EAH52_RS03100	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EAH52_RS03105	COG0521	Mo-molybdopterin cofactor biosynthetic process
EAH52_RS03110	COG0315	cyclic pyranopterin monophosphate synthase activity
EAH52_RS03120	COG1763	Mo-molybdopterin cofactor biosynthetic process
EAH52_RS03140	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EAH52_RS03150	COG2814	Major facilitator Superfamily
EAH52_RS03170	COG2348	transferase activity, transferring amino-acyl groups
EAH52_RS03175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EAH52_RS03195	COG4975	Glucose uptake
EAH52_RS03210	COG2252	PERMEase
EAH52_RS03225	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EAH52_RS03230	COG0088	Forms part of the polypeptide exit tunnel
EAH52_RS03235	COG0089	rRNA binding
EAH52_RS03240	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EAH52_RS03245	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EAH52_RS03250	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EAH52_RS03255	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EAH52_RS03260	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EAH52_RS03270	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EAH52_RS03275	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EAH52_RS03280	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EAH52_RS03290	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EAH52_RS03295	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EAH52_RS03300	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EAH52_RS03305	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EAH52_RS03310	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EAH52_RS03315	COG1841	ribosomal large subunit assembly
EAH52_RS03325	COG0201	protein transport
EAH52_RS03330	COG0563	adenylate kinase activity
EAH52_RS03335	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EAH52_RS03345	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EAH52_RS03350	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EAH52_RS03355	COG0202	RNA polymerase activity
EAH52_RS03370	COG1122	ATPase activity
EAH52_RS03385	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EAH52_RS03400	COG0789	Transcriptional regulator
EAH52_RS03415	COG0698	ribose 5-phosphate isomerase
EAH52_RS03455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EAH52_RS03460	COG2130	NADP-dependent
EAH52_RS03465	COG0604	alcohol dehydrogenase
EAH52_RS03470	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EAH52_RS03485	COG1302	Protein conserved in bacteria
EAH52_RS03495	COG2814	Major facilitator Superfamily
EAH52_RS03500	COG4264	IucA IucC family
EAH52_RS03505	COG3457	Alanine racemase
EAH52_RS03510	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EAH52_RS03515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EAH52_RS03520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EAH52_RS03525	COG3314	Sporulation integral membrane protein YlbJ
EAH52_RS03530	COG2329	Antibiotic biosynthesis monooxygenase
EAH52_RS03540	COG1988	membrane-bound metal-dependent
EAH52_RS03545	COG4284	Utp--glucose-1-phosphate uridylyltransferase
EAH52_RS03550	COG1272	protein, Hemolysin III
EAH52_RS03565	COG2814	Major facilitator Superfamily
EAH52_RS03570	COG0489	protein tyrosine kinase activity
EAH52_RS03625	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EAH52_RS03650	COG3711	transcriptional antiterminator
EAH52_RS03665	COG0561	phosphatase activity
EAH52_RS03685	COG0640	Transcriptional regulator
EAH52_RS03690	COG0702	epimerase
EAH52_RS03695	COG1482	cell wall glycoprotein biosynthetic process
EAH52_RS03715	COG0783	Belongs to the Dps family
EAH52_RS03720	COG0813	purine-nucleoside phosphorylase activity
EAH52_RS03725	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EAH52_RS03730	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EAH52_RS03735	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EAH52_RS03745	COG1854	S-ribosylhomocysteine lyase activity
EAH52_RS03765	COG5146	pantothenate kinase activity
EAH52_RS03780	COG0504	CTP synthase activity
EAH52_RS03790	COG0191	fructose-bisphosphate aldolase activity
EAH52_RS03795	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EAH52_RS03805	COG1012	belongs to the aldehyde dehydrogenase family
EAH52_RS03810	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EAH52_RS03815	COG0254	rRNA binding
EAH52_RS03820	COG1435	thymidine kinase activity
EAH52_RS03830	COG2890	protein-(glutamine-N5) methyltransferase activity
EAH52_RS03835	COG0009	L-threonylcarbamoyladenylate synthase
EAH52_RS03840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EAH52_RS03845	COG4475	Protein of unknown function (DUF436)
EAH52_RS03855	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EAH52_RS03860	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EAH52_RS03885	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EAH52_RS03895	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EAH52_RS03900	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EAH52_RS03905	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EAH52_RS03920	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EAH52_RS03935	COG0629	single-stranded DNA binding
EAH52_RS03940	COG1388	LysM domain
EAH52_RS03945	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EAH52_RS03955	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EAH52_RS03960	COG0352	thiamine-phosphate diphosphorylase activity
EAH52_RS03965	COG0706	membrane insertase activity
EAH52_RS03970	COG1418	mRNA catabolic process
EAH52_RS03975	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EAH52_RS03980	COG1937	Protein conserved in bacteria
EAH52_RS03995	COG0772	Belongs to the SEDS family
EAH52_RS04000	COG1181	Belongs to the D-alanine--D-alanine ligase family
EAH52_RS04005	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EAH52_RS04010	COG0513	Belongs to the DEAD box helicase family
EAH52_RS04020	COG3428	Bacterial PH domain
EAH52_RS04030	COG0736	holo-[acyl-carrier-protein] synthase activity
EAH52_RS04035	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EAH52_RS04045	COG2337	Toxic component of a toxin-antitoxin (TA) module
EAH52_RS04055	COG2208	phosphoserine phosphatase activity
EAH52_RS04070	COG1191	sigma factor activity
EAH52_RS04075	COG2183	response to ionizing radiation
EAH52_RS04120	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EAH52_RS04125	COG0473	3-isopropylmalate dehydrogenase activity
EAH52_RS04145	COG0028	Belongs to the TPP enzyme family
EAH52_RS04150	COG0129	dihydroxy-acid dehydratase activity
EAH52_RS04155	COG0802	atpase or kinase
EAH52_RS04160	COG1214	PFAM Peptidase M22, glycoprotease
EAH52_RS04165	COG0456	acetyltransferase
EAH52_RS04170	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EAH52_RS04180	COG0488	(ABC) transporter
EAH52_RS04195	COG2391	methyltransferase activity
EAH52_RS04200	COG0425	Belongs to the sulfur carrier protein TusA family
EAH52_RS04205	COG1609	Transcriptional regulator
EAH52_RS04210	COG1621	beta-fructofuranosidase activity
EAH52_RS04215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EAH52_RS04225	COG3290	protein histidine kinase activity
EAH52_RS04270	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EAH52_RS04275	COG0459	protein refolding
EAH52_RS04280	COG0582	viral genome integration into host DNA
EAH52_RS04430	COG1725	Transcriptional regulator
EAH52_RS04445	COG1131	(ABC) transporter
EAH52_RS04490	COG2706	6-phosphogluconolactonase activity
EAH52_RS04495	COG1012	belongs to the aldehyde dehydrogenase family
EAH52_RS04500	COG1227	inorganic diphosphatase activity
EAH52_RS04505	COG1335	isochorismatase
EAH52_RS04515	COG0077	Prephenate dehydratase
EAH52_RS04525	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EAH52_RS04530	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EAH52_RS04535	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
EAH52_RS04545	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EAH52_RS04550	COG4496	protein, YerC YecD
EAH52_RS04555	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
EAH52_RS04560	COG0210	DNA helicase
EAH52_RS04565	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EAH52_RS04575	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EAH52_RS04590	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EAH52_RS04595	COG1597	lipid kinase activity
EAH52_RS04600	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EAH52_RS04620	COG1528	Iron-storage protein
EAH52_RS04635	COG4129	membrane
EAH52_RS04640	COG0024	Methionine aminopeptidase
EAH52_RS04660	COG2197	response regulator
EAH52_RS04665	COG1295	ribonuclease BN
EAH52_RS04680	COG4840	Belongs to the UPF0435 family
EAH52_RS04685	COG2309	aminopeptidase activity
EAH52_RS04695	COG0535	radical SAM domain protein
EAH52_RS04705	COG0693	protein deglycase activity
EAH52_RS04710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EAH52_RS04725	COG1134	teichoic acid transport
EAH52_RS04725	COG1388	LysM domain
EAH52_RS04735	COG1988	membrane-bound metal-dependent
EAH52_RS04740	COG1194	a g-specific adenine glycosylase
EAH52_RS04745	COG3557	Belongs to the UPF0374 family
EAH52_RS04755	COG4129	membrane
EAH52_RS04760	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EAH52_RS04765	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EAH52_RS04770	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EAH52_RS04775	COG0735	belongs to the Fur family
EAH52_RS04940	COG0765	amino acid transport
EAH52_RS04945	COG1126	abc transporter atp-binding protein
EAH52_RS04950	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EAH52_RS04960	COG0363	glucosamine-6-phosphate deaminase activity
EAH52_RS04975	COG0114	fumarate hydratase activity
EAH52_RS04980	COG0564	pseudouridine synthase activity
EAH52_RS04985	COG2203	Gaf domain
EAH52_RS04985	COG4585	Histidine kinase
EAH52_RS04990	COG2197	response regulator
EAH52_RS05000	COG4399	Belongs to the UPF0754 family
EAH52_RS05005	COG3679	Belongs to the UPF0342 family
EAH52_RS05010	COG0420	3'-5' exonuclease activity
EAH52_RS05020	COG3481	metal-dependent phosphohydrolase, HD sub domain
EAH52_RS05030	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EAH52_RS05045	COG0537	adenosine 5'-monophosphoramidase activity
EAH52_RS05050	COG1131	(ABC) transporter
EAH52_RS05055	COG4473	ABC transporter
EAH52_RS05060	COG2329	Antibiotic biosynthesis monooxygenase
EAH52_RS05070	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EAH52_RS05075	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EAH52_RS05080	COG3545	Serine hydrolase
EAH52_RS05130	COG0318	PFAM AMP-dependent synthetase and ligase
EAH52_RS05145	COG0494	nUDIX hydrolase
EAH52_RS05150	COG1506	peptidase
EAH52_RS05160	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EAH52_RS05170	COG0656	L-ascorbic acid biosynthetic process
EAH52_RS05175	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EAH52_RS05180	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EAH52_RS05190	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EAH52_RS05215	COG3266	domain, Protein
EAH52_RS05215	COG4193	domain, Protein
EAH52_RS05215	COG5632	N-Acetylmuramoyl-L-alanine amidase
EAH52_RS05225	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EAH52_RS05225	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EAH52_RS05230	COG0307	riboflavin synthase, alpha
EAH52_RS05235	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EAH52_RS05235	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EAH52_RS05240	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EAH52_RS05250	COG2267	carboxylic ester hydrolase activity
EAH52_RS05260	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EAH52_RS05265	COG1242	4 iron, 4 sulfur cluster binding
EAH52_RS05270	COG2814	Major facilitator Superfamily
EAH52_RS05275	COG0495	leucyl-tRNA aminoacylation
EAH52_RS05280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EAH52_RS05295	COG2081	HI0933 family
EAH52_RS05300	COG2244	polysaccharide biosynthetic process
EAH52_RS05305	COG1187	pseudouridine synthase activity
EAH52_RS05315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EAH52_RS05320	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EAH52_RS05325	COG0510	thiamine kinase activity
EAH52_RS05330	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EAH52_RS05335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EAH52_RS05345	COG1363	Peptidase, m42
EAH52_RS05350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EAH52_RS05355	COG4848	Belongs to the UPF0354 family
EAH52_RS05360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EAH52_RS05365	COG1674	ftsk spoiiie
EAH52_RS05370	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EAH52_RS05385	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EAH52_RS05385	COG1605	Chorismate mutase
EAH52_RS05390	COG1609	Transcriptional regulator
EAH52_RS05400	COG0454	-acetyltransferase
EAH52_RS05405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EAH52_RS05415	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EAH52_RS05430	COG2814	Major facilitator Superfamily
EAH52_RS05435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EAH52_RS05440	COG0204	Acyl-transferase
EAH52_RS05460	COG1263	PTS System
EAH52_RS05460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EAH52_RS05470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EAH52_RS05475	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EAH52_RS05480	COG1764	response to oxidative stress
EAH52_RS05485	COG0584	glycerophosphoryl diester phosphodiesterase
EAH52_RS05495	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EAH52_RS05505	COG1956	GAF domain-containing protein
EAH52_RS05510	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
EAH52_RS05515	COG1104	cysteine desulfurase activity
EAH52_RS05520	COG0301	tRNA thio-modification
EAH52_RS05530	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EAH52_RS05535	COG0827	DNA restriction-modification system
EAH52_RS05540	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EAH52_RS05545	COG0589	response to stress
EAH52_RS05550	COG0686	Belongs to the AlaDH PNT family
EAH52_RS05555	COG0006	proline dipeptidase activity
EAH52_RS05560	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EAH52_RS05570	COG4109	DRTGG domain
EAH52_RS05575	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EAH52_RS05580	COG0587	DNA-directed DNA polymerase activity
EAH52_RS05585	COG0281	malic enzyme
EAH52_RS05590	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EAH52_RS05600	COG0205	6-phosphofructokinase activity
EAH52_RS05605	COG0469	pyruvate kinase activity
EAH52_RS05610	COG1113	amino acid transport
EAH52_RS05615	COG0372	Belongs to the citrate synthase family
EAH52_RS05620	COG0538	isocitrate dehydrogenase activity
EAH52_RS05625	COG0745	RESPONSE REGULATOR receiver
EAH52_RS05630	COG5002	protein histidine kinase activity
EAH52_RS05635	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EAH52_RS05635	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EAH52_RS05640	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EAH52_RS05650	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EAH52_RS05655	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EAH52_RS05660	COG3611	Membrane attachment protein
EAH52_RS05665	COG1484	DNA-dependent DNA replication
EAH52_RS05675	COG0833	amino acid
EAH52_RS05680	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EAH52_RS05685	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EAH52_RS05690	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EAH52_RS05695	COG4112	unkown
EAH52_RS05705	COG0544	peptidyl-prolyl cis-trans isomerase activity
EAH52_RS05710	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EAH52_RS05715	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EAH52_RS05720	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EAH52_RS05725	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EAH52_RS05730	COG0181	hydroxymethylbilane synthase activity
EAH52_RS05740	COG0113	porphobilinogen synthase activity
EAH52_RS05745	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EAH52_RS05755	COG2818	Glycosylase
EAH52_RS05760	COG0525	valine-tRNA ligase activity
EAH52_RS05765	COG0285	dihydrofolate synthase activity
EAH52_RS05775	COG2003	Belongs to the UPF0758 family
EAH52_RS05810	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EAH52_RS05815	COG2868	ribosomal protein
EAH52_RS05820	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EAH52_RS05825	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EAH52_RS05830	COG4492	Belongs to the UPF0735 family
EAH52_RS05835	COG0632	four-way junction helicase activity
EAH52_RS05845	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EAH52_RS05855	COG1862	Preprotein translocase
EAH52_RS05860	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EAH52_RS05860	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EAH52_RS05865	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EAH52_RS05865	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EAH52_RS05875	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EAH52_RS05885	COG0860	N-Acetylmuramoyl-L-alanine amidase
EAH52_RS05895	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EAH52_RS05905	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EAH52_RS05910	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EAH52_RS05915	COG1959	2 iron, 2 sulfur cluster binding
EAH52_RS05935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EAH52_RS05940	COG1104	cysteine desulfurase activity
EAH52_RS05945	COG0482	sulfurtransferase activity
EAH52_RS05955	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EAH52_RS05965	COG4472	Bacterial protein of unknown function (DUF965)
EAH52_RS05975	COG3906	Belongs to the UPF0473 family
EAH52_RS05980	COG4122	O-methyltransferase activity
EAH52_RS05985	COG0826	peptidase U32
EAH52_RS05990	COG0826	peptidase U32
EAH52_RS05995	COG0572	uridine kinase
EAH52_RS06000	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EAH52_RS06005	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EAH52_RS06010	COG1984	allophanate hydrolase subunit 2
EAH52_RS06015	COG0511	ligase activity, forming carbon-carbon bonds
EAH52_RS06020	COG0439	Biotin carboxylase
EAH52_RS06030	COG1914	H( )-stimulated, divalent metal cation uptake system
EAH52_RS06035	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EAH52_RS06040	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
EAH52_RS06045	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EAH52_RS06050	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EAH52_RS06055	COG1534	Rna-binding protein
EAH52_RS06060	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EAH52_RS06065	COG1713	HD superfamily hydrolase involved in NAD metabolism
EAH52_RS06070	COG0799	negative regulation of ribosome biogenesis
EAH52_RS06085	COG2131	deaminase
EAH52_RS06090	COG2333	competence protein COMEC
EAH52_RS06090	COG0658	competence protein
EAH52_RS06095	COG1466	dna polymerase III delta subunit
EAH52_RS06100	COG0268	Binds directly to 16S ribosomal RNA
EAH52_RS06105	COG0481	GTPase activity
EAH52_RS06110	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EAH52_RS06120	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EAH52_RS06125	COG0443	Heat shock 70 kDa protein
EAH52_RS06130	COG0484	heat shock protein binding
EAH52_RS06140	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EAH52_RS06145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EAH52_RS06155	COG1030	water channel activity
EAH52_RS06160	COG4864	UPF0365 protein
EAH52_RS06170	COG1702	phosphate starvation-inducible protein PhoH
EAH52_RS06190	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EAH52_RS06195	COG1381	Involved in DNA repair and RecF pathway recombination
EAH52_RS06200	COG0423	glycine-tRNA ligase activity
EAH52_RS06205	COG0517	IMP dehydrogenase activity
EAH52_RS06210	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EAH52_RS06220	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EAH52_RS06225	COG2384	SAM-dependent methyltransferase
EAH52_RS06230	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EAH52_RS06235	COG0513	Belongs to the DEAD box helicase family
EAH52_RS06240	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EAH52_RS06245	COG1121	(ABC) transporter
EAH52_RS06250	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EAH52_RS06265	COG0768	penicillin binding
EAH52_RS06270	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EAH52_RS06275	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EAH52_RS06285	COG4483	Protein conserved in bacteria
EAH52_RS06290	COG1940	carbohydrate kinase activity
EAH52_RS06295	COG0011	TIGRFAM Protein of
EAH52_RS06300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EAH52_RS06305	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EAH52_RS06310	COG1459	type II secretion system
EAH52_RS06315	COG4537	Required for transformation and DNA binding
EAH52_RS06335	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EAH52_RS06340	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EAH52_RS06355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EAH52_RS06360	COG0095	Lipoate-protein ligase
EAH52_RS06375	COG0006	proline dipeptidase activity
EAH52_RS06380	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EAH52_RS06385	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EAH52_RS06390	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EAH52_RS06395	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EAH52_RS06400	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EAH52_RS06405	COG0511	ligase activity, forming carbon-carbon bonds
EAH52_RS06410	COG0439	Biotin carboxylase
EAH52_RS06415	COG1302	Protein conserved in bacteria
EAH52_RS06420	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EAH52_RS06430	COG1722	exodeoxyribonuclease VII activity
EAH52_RS06435	COG0142	geranyltranstransferase activity
EAH52_RS06440	COG1438	arginine binding
EAH52_RS06445	COG0497	DNA recombination
EAH52_RS06450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EAH52_RS06455	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EAH52_RS06460	COG0022	dehydrogenase e1 component
EAH52_RS06465	COG0508	dehydrogenase complex catalyzes the overall conversion of
EAH52_RS06475	COG4129	membrane
EAH52_RS06480	COG2195	Cleaves the N-terminal amino acid of tripeptides
EAH52_RS06485	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EAH52_RS06490	COG0366	Alpha amylase catalytic
EAH52_RS06500	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EAH52_RS06505	COG1234	tRNA 3'-trailer cleavage
EAH52_RS06510	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EAH52_RS06515	COG1028	Short-chain dehydrogenase reductase Sdr
EAH52_RS06520	COG0667	Aldo Keto reductase
EAH52_RS06525	COG0494	nUDIX hydrolase
EAH52_RS06530	COG0735	belongs to the Fur family
EAH52_RS06535	COG4974	Belongs to the 'phage' integrase family
EAH52_RS06545	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EAH52_RS06550	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EAH52_RS06555	COG1187	pseudouridine synthase activity
EAH52_RS06560	COG0745	RESPONSE REGULATOR receiver
EAH52_RS06575	COG1141	Ferredoxin
EAH52_RS06585	COG0514	ATP-dependent DNA helicase (RecQ)
EAH52_RS06595	COG0492	ferredoxin-NADP+ reductase activity
EAH52_RS06600	COG0252	asparaginase activity
EAH52_RS06605	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EAH52_RS06610	COG0539	negative regulation of cytoplasmic translation
EAH52_RS06615	COG1160	GTP binding
EAH52_RS06620	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EAH52_RS06635	COG2226	methyltransferase
EAH52_RS06650	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EAH52_RS06655	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EAH52_RS06670	COG5582	Belongs to the UPF0302 family
EAH52_RS06675	COG4347	Protein of unknown function (DUF1405)
EAH52_RS06680	COG2738	Putative neutral zinc metallopeptidase
EAH52_RS06685	COG1694	Mazg nucleotide pyrophosphohydrolase
EAH52_RS06690	COG0438	transferase activity, transferring glycosyl groups
EAH52_RS06695	COG0617	tRNA 3'-terminal CCA addition
EAH52_RS06700	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EAH52_RS06700	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EAH52_RS06705	COG1199	ATP-dependent helicase activity
EAH52_RS06705	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EAH52_RS06710	COG0017	Asparaginyl-tRNA synthetase
EAH52_RS06715	COG3935	DnaD domain protein
EAH52_RS06720	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EAH52_RS06730	COG4499	WXG100 protein secretion system (Wss), protein YukC
EAH52_RS06730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EAH52_RS06735	COG3331	DNA recombination
EAH52_RS06750	COG3599	regulation of cell shape
EAH52_RS06760	COG0116	Belongs to the methyltransferase superfamily
EAH52_RS06770	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EAH52_RS06775	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EAH52_RS06790	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EAH52_RS06800	COG1413	lyase activity
EAH52_RS06805	COG1413	lyase activity
EAH52_RS06835	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EAH52_RS06840	COG2190	(PTS) system
EAH52_RS06850	COG0793	Belongs to the peptidase S41A family
EAH52_RS06860	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EAH52_RS06865	COG0671	phosphoesterase, PA-phosphatase related
EAH52_RS06870	COG0745	RESPONSE REGULATOR receiver
EAH52_RS06875	COG5002	protein histidine kinase activity
EAH52_RS06880	COG0567	Dehydrogenase, E1 component
EAH52_RS06885	COG0508	dehydrogenase complex catalyzes the overall conversion of
EAH52_RS06890	COG1131	(ABC) transporter
EAH52_RS06915	COG0714	Associated with various cellular activities
EAH52_RS06920	COG4548	von Willebrand factor, type A
EAH52_RS06925	COG1114	Component of the transport system for branched-chain amino acids
EAH52_RS06930	COG3853	Toxic anion resistance protein (TelA)
EAH52_RS06940	COG1254	Belongs to the acylphosphatase family
EAH52_RS06950	COG1278	Cold shock
EAH52_RS06965	COG1473	amidohydrolase
EAH52_RS06975	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EAH52_RS06980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EAH52_RS06985	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EAH52_RS06990	COG0527	aspartate kinase activity
EAH52_RS07000	COG0488	(ABC) transporter
EAH52_RS07005	COG2996	Protein conserved in bacteria
EAH52_RS07010	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EAH52_RS07015	COG0573	inorganic phosphate transmembrane transporter activity
EAH52_RS07020	COG0581	inorganic phosphate transmembrane transporter activity
EAH52_RS07025	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EAH52_RS07065	COG4607	ABC-type enterochelin transport system periplasmic component
EAH52_RS07070	COG0561	phosphatase activity
EAH52_RS07075	COG2348	transferase activity, transferring amino-acyl groups
EAH52_RS07080	COG2348	transferase activity, transferring amino-acyl groups
EAH52_RS07100	COG0134	indole-3-glycerol-phosphate synthase activity
EAH52_RS07110	COG0512	Glutamine amidotransferase of anthranilate synthase
EAH52_RS07115	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EAH52_RS07120	COG1363	Peptidase, m42
EAH52_RS07130	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EAH52_RS07135	COG1942	4-Oxalocrotonate Tautomerase
EAH52_RS07150	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EAH52_RS07150	COG0392	lysyltransferase activity
EAH52_RS07155	COG0628	permease
EAH52_RS07160	COG3711	transcriptional antiterminator
EAH52_RS07165	COG1115	amino acid carrier protein
EAH52_RS07170	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EAH52_RS07175	COG0187	DNA topoisomerase II activity
EAH52_RS07190	COG0824	Thioesterase
EAH52_RS07195	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EAH52_RS07200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EAH52_RS07205	COG1970	mechanosensitive ion channel activity
EAH52_RS07220	COG4846	Membrane protein involved in cytochrome C biogenesis
EAH52_RS07230	COG3763	UPF0154 protein
EAH52_RS07240	COG4224	UPF0291 protein
EAH52_RS07265	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EAH52_RS07280	COG0833	amino acid
EAH52_RS07295	COG0083	homoserine kinase activity
EAH52_RS07300	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EAH52_RS07305	COG0460	homoserine dehydrogenase
EAH52_RS07310	COG0527	aspartate kinase activity
EAH52_RS07325	COG1525	nuclease
EAH52_RS07335	COG2197	response regulator
EAH52_RS07350	COG1131	(ABC) transporter
EAH52_RS07390	COG0789	Transcriptional regulator
EAH52_RS07395	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
EAH52_RS07400	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EAH52_RS07405	COG0386	Belongs to the glutathione peroxidase family
EAH52_RS07410	COG1923	regulation of RNA biosynthetic process
EAH52_RS07415	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EAH52_RS07425	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EAH52_RS07435	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EAH52_RS07440	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EAH52_RS07445	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EAH52_RS07460	COG4550	Control of competence regulator ComK, YlbF/YmcA
EAH52_RS07465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EAH52_RS07475	COG4195	phage-related replication protein
EAH52_RS07480	COG1013	pyruvate-flavodoxin oxidoreductase activity
EAH52_RS07485	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EAH52_RS07485	COG0674	pyruvate-flavodoxin oxidoreductase activity
EAH52_RS07490	COG1692	metallophosphoesterase
EAH52_RS07500	COG1418	mRNA catabolic process
EAH52_RS07505	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EAH52_RS07510	COG1546	Belongs to the CinA family
EAH52_RS07510	COG1058	Belongs to the CinA family
EAH52_RS07520	COG1426	Protein conserved in bacteria
EAH52_RS07530	COG1028	Short-chain dehydrogenase reductase Sdr
EAH52_RS07535	COG0612	Peptidase, M16
EAH52_RS07540	COG0612	Peptidase, M16
EAH52_RS07545	COG2188	Transcriptional regulator
EAH52_RS07555	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EAH52_RS07565	COG1185	polyribonucleotide nucleotidyltransferase activity
EAH52_RS07570	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EAH52_RS07575	COG0196	riboflavin kinase activity
EAH52_RS07580	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EAH52_RS07585	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EAH52_RS07590	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EAH52_RS07595	COG1358	cellular component organization or biogenesis
EAH52_RS07600	COG2740	Nucleic-acid-binding protein implicated in transcription termination
EAH52_RS07605	COG0195	Participates in both transcription termination and antitermination
EAH52_RS07610	COG0779	Required for maturation of 30S ribosomal subunits
EAH52_RS07615	COG2176	DNA-directed DNA polymerase activity
EAH52_RS07620	COG0442	prolyl-tRNA aminoacylation
EAH52_RS07630	COG4589	Belongs to the CDS family
EAH52_RS07635	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EAH52_RS07640	COG0233	cytoplasmic translational termination
EAH52_RS07645	COG0528	UMP kinase activity
EAH52_RS07650	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EAH52_RS07655	COG0052	Belongs to the universal ribosomal protein uS2 family
EAH52_RS07670	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EAH52_RS07675	COG4974	Belongs to the 'phage' integrase family
EAH52_RS07680	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EAH52_RS07685	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EAH52_RS07690	COG0758	DNA mediated transformation
EAH52_RS07695	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EAH52_RS07700	COG0045	succinate-CoA ligase (ADP-forming) activity
EAH52_RS07705	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EAH52_RS07715	COG4485	Bacterial membrane protein, YfhO
EAH52_RS07730	COG0336	Belongs to the RNA methyltransferase TrmD family
EAH52_RS07735	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EAH52_RS07740	COG0228	four-way junction DNA binding
EAH52_RS07745	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EAH52_RS07750	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
EAH52_RS07755	COG0552	protein localization to endoplasmic reticulum
EAH52_RS07760	COG1196	nuclear chromosome segregation
EAH52_RS07765	COG0571	ribonuclease III activity
EAH52_RS07770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EAH52_RS07785	COG0416	fatty acid biosynthetic process
EAH52_RS07790	COG1349	DNA-binding transcription factor activity
EAH52_RS07795	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EAH52_RS07800	COG1461	Dihydroxyacetone kinase
EAH52_RS07805	COG1302	Protein conserved in bacteria
EAH52_RS07810	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EAH52_RS07820	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EAH52_RS07835	COG0631	protein serine/threonine phosphatase activity
EAH52_RS07840	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EAH52_RS07845	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EAH52_RS07845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EAH52_RS07850	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EAH52_RS07855	COG0242	peptide deformylase activity
EAH52_RS07865	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EAH52_RS07870	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EAH52_RS07875	COG1758	RNA polymerase activity
EAH52_RS07880	COG0194	GDP metabolic process
EAH52_RS07900	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EAH52_RS07905	COG0284	orotidine-5'-phosphate decarboxylase activity
EAH52_RS07910	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EAH52_RS07915	COG0505	Belongs to the CarA family
EAH52_RS07920	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EAH52_RS07925	COG0540	Belongs to the ATCase OTCase family
EAH52_RS07930	COG2233	PERMEase
EAH52_RS07935	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EAH52_RS07945	COG0564	pseudouridine synthase activity
EAH52_RS07955	COG1388	LysM domain
EAH52_RS07955	COG3942	CHAP domain
EAH52_RS07965	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EAH52_RS07970	COG3599	regulation of cell shape
EAH52_RS07980	COG0762	integral membrane protein
EAH52_RS07985	COG1799	cell septum assembly
EAH52_RS07990	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EAH52_RS07995	COG1496	oxidoreductase activity
EAH52_RS08000	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EAH52_RS08005	COG0849	cell division
EAH52_RS08010	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EAH52_RS08020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EAH52_RS08025	COG0768	penicillin binding
EAH52_RS08030	COG4839	cell division protein FtsL
EAH52_RS08035	COG0275	rRNA processing
EAH52_RS08045	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
EAH52_RS08055	COG1011	Hydrolase
EAH52_RS08105	COG1388	LysM domain
EAH52_RS08105	COG5632	N-Acetylmuramoyl-L-alanine amidase
EAH52_RS08220	COG3620	sequence-specific DNA binding
EAH52_RS08300	COG1484	DNA-dependent DNA replication
EAH52_RS08365	COG1476	TRANSCRIPTIONal
EAH52_RS08380	COG0582	viral genome integration into host DNA
EAH52_RS08390	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EAH52_RS08395	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EAH52_RS08400	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EAH52_RS08405	COG1053	succinate dehydrogenase
EAH52_RS08410	COG2009	succinate dehydrogenase
EAH52_RS08415	COG0322	excinuclease ABC activity
EAH52_RS08420	COG3118	belongs to the thioredoxin family
EAH52_RS08425	COG1193	negative regulation of DNA recombination
EAH52_RS08430	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EAH52_RS08430	COG1796	DNA polymerase
EAH52_RS08440	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EAH52_RS08445	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EAH52_RS08450	COG0072	phenylalanine-tRNA ligase activity
EAH52_RS08450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EAH52_RS08455	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EAH52_RS08460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EAH52_RS08465	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EAH52_RS08480	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EAH52_RS08485	COG0742	ribosomal rna small subunit methyltransferase
EAH52_RS08500	COG0584	glycerophosphoryl diester phosphodiesterase
EAH52_RS08505	COG3679	Belongs to the UPF0342 family
EAH52_RS08520	COG0109	protoheme IX farnesyltransferase activity
EAH52_RS08525	COG1612	heme a metabolic process
EAH52_RS08535	COG0772	Belongs to the SEDS family
EAH52_RS08540	COG4838	Belongs to the UPF0358 family
EAH52_RS08545	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EAH52_RS08550	COG4896	Protein conserved in bacteria
EAH52_RS08555	COG1217	gtp-binding protein TYPA
EAH52_RS08565	COG0483	inositol monophosphate 1-phosphatase activity
EAH52_RS08570	COG4493	Belongs to the UPF0637 family
EAH52_RS08600	COG1176	ABC-type spermidine putrescine transport system, permease component I
EAH52_RS08615	COG4476	Belongs to the UPF0223 family
EAH52_RS08625	COG0508	dehydrogenase complex catalyzes the overall conversion of
EAH52_RS08645	COG0242	peptide deformylase activity
EAH52_RS08650	COG5503	Protein of unknown function (DUF1447)
EAH52_RS08655	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EAH52_RS08660	COG0569	domain protein
EAH52_RS08665	COG1294	oxidase, subunit
EAH52_RS08670	COG1271	oxidase subunit
EAH52_RS08680	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EAH52_RS08685	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EAH52_RS08695	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EAH52_RS08715	COG4172	Belongs to the ABC transporter superfamily
EAH52_RS08720	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EAH52_RS08725	COG0151	Belongs to the GarS family
EAH52_RS08730	COG0138	bifunctional purine biosynthesis protein purh
EAH52_RS08740	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EAH52_RS08755	COG0047	phosphoribosylformylglycinamidine synthase activity
EAH52_RS08760	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EAH52_RS08765	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EAH52_RS08775	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EAH52_RS08780	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EAH52_RS08785	COG1017	nitric oxide dioxygenase activity
EAH52_RS08785	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EAH52_RS08795	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EAH52_RS08810	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
EAH52_RS08825	COG1316	TRANSCRIPTIONal
EAH52_RS08850	COG3594	Acyltransferase
EAH52_RS08855	COG0436	Aminotransferase
EAH52_RS08860	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EAH52_RS08870	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EAH52_RS08875	COG1169	isochorismate synthase
EAH52_RS08880	COG1575	Belongs to the MenA family. Type 1 subfamily
EAH52_RS08885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EAH52_RS08890	COG2314	TM2 domain
EAH52_RS08925	COG4873	Protein conserved in bacteria
EAH52_RS08940	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EAH52_RS08945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EAH52_RS08950	COG0861	Integral membrane protein TerC family
EAH52_RS08955	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EAH52_RS08965	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EAH52_RS08970	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EAH52_RS08975	COG2814	Major facilitator Superfamily
EAH52_RS08980	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EAH52_RS08985	COG2382	esterase
EAH52_RS08990	COG1115	amino acid carrier protein
EAH52_RS08995	COG0628	permease
EAH52_RS09005	COG0475	glutathione-regulated potassium exporter activity
EAH52_RS09005	COG0569	domain protein
EAH52_RS09010	COG2239	Acts as a magnesium transporter
EAH52_RS09015	COG0564	pseudouridine synthase activity
EAH52_RS09020	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EAH52_RS09025	COG2357	RelA SpoT domain protein
EAH52_RS09040	COG2346	COG2346, Truncated hemoglobins
EAH52_RS09045	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EAH52_RS09050	COG1164	Oligoendopeptidase f
EAH52_RS09060	COG4862	establishment of competence for transformation
EAH52_RS09065	COG1393	Belongs to the ArsC family
EAH52_RS09070	COG0180	Tryptophanyl-tRNA synthetase
EAH52_RS09075	COG4166	transmembrane transport
EAH52_RS09080	COG4608	Belongs to the ABC transporter superfamily
EAH52_RS09085	COG0444	Belongs to the ABC transporter superfamily
EAH52_RS09095	COG0601	transmembrane transport
EAH52_RS09110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EAH52_RS09120	COG0542	response to heat
EAH52_RS09135	COG0561	phosphatase activity
EAH52_RS09140	COG0446	pyridine nucleotide-disulphide oxidoreductase
EAH52_RS09155	COG1074	ATP-dependent DNA helicase activity
EAH52_RS09175	COG0398	Pfam SNARE associated Golgi protein
EAH52_RS09185	COG0137	argininosuccinate synthase activity
EAH52_RS09190	COG0165	Argininosuccinate lyase
EAH52_RS09195	COG0584	glycerophosphoryl diester phosphodiesterase
EAH52_RS09200	COG0584	glycerophosphoryl diester phosphodiesterase
EAH52_RS09220	COG1902	pentaerythritol trinitrate reductase activity
EAH52_RS09225	COG1098	S1 RNA binding domain
EAH52_RS09240	COG2111	Na H antiporter
EAH52_RS09240	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EAH52_RS09245	COG2111	Na H antiporter
EAH52_RS09250	COG1006	Multisubunit Na H antiporter MnhC subunit
EAH52_RS09255	COG0651	ATP synthesis coupled electron transport
EAH52_RS09265	COG2212	antiporter activity
EAH52_RS09285	COG2050	protein possibly involved in aromatic compounds catabolism
EAH52_RS09290	COG2056	Na+-H+ antiporter family
EAH52_RS09295	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EAH52_RS09305	COG0316	Belongs to the HesB IscA family
EAH52_RS09310	COG4844	belongs to the
EAH52_RS09315	COG1252	NADH dehydrogenase
EAH52_RS09320	COG4837	Protein of unknown function (DUF1462)
EAH52_RS09325	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EAH52_RS09330	COG0583	DNA-binding transcription factor activity
EAH52_RS09340	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EAH52_RS09350	COG1696	Membrane protein involved in D-alanine export
EAH52_RS09355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EAH52_RS09375	COG2445	Protein of unknown function DUF86
EAH52_RS09385	COG4470	Protein conserved in bacteria
EAH52_RS09390	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EAH52_RS09395	COG0737	Belongs to the 5'-nucleotidase family
EAH52_RS09400	COG0730	response to heat
EAH52_RS09405	COG1801	Protein of unknown function DUF72
EAH52_RS09410	COG2070	2-Nitropropane dioxygenase
EAH52_RS09415	COG1253	flavin adenine dinucleotide binding
EAH52_RS09420	COG0719	Fe-S assembly protein
EAH52_RS09425	COG0822	iron-sulfur transferase activity
EAH52_RS09430	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EAH52_RS09435	COG0719	Fe-S assembly protein
EAH52_RS09440	COG0396	ATPase activity
EAH52_RS09450	COG3237	CsbD-like
EAH52_RS09455	COG1464	Belongs to the NlpA lipoprotein family
EAH52_RS09460	COG2011	ABC-type metal ion transport system permease component
EAH52_RS09465	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EAH52_RS09475	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EAH52_RS09480	COG0509	glycine decarboxylation via glycine cleavage system
EAH52_RS09485	COG1393	Belongs to the ArsC family
EAH52_RS09490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EAH52_RS09500	COG0710	3-dehydroquinate dehydratase activity
EAH52_RS09505	COG1764	response to oxidative stress
EAH52_RS09515	COG0406	alpha-ribazole phosphatase activity
EAH52_RS09550	COG4195	phage-related replication protein
EAH52_RS09575	COG1278	Cold shock
EAH52_RS09600	COG0656	L-ascorbic acid biosynthetic process
EAH52_RS09605	COG1309	transcriptional regulator
EAH52_RS09675	COG0557	exoribonuclease II activity
EAH52_RS09680	COG1647	Serine aminopeptidase, S33
EAH52_RS09685	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EAH52_RS09695	COG0148	phosphopyruvate hydratase activity
EAH52_RS09700	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EAH52_RS09705	COG0149	triose-phosphate isomerase activity
EAH52_RS09710	COG0126	phosphoglycerate kinase activity
EAH52_RS09720	COG2390	Transcriptional regulator
EAH52_RS09745	COG0740	serine-type endopeptidase activity
EAH52_RS09755	COG1481	regulation of sporulation
EAH52_RS09760	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EAH52_RS09765	COG1660	Displays ATPase and GTPase activities
EAH52_RS09770	COG0492	ferredoxin-NADP+ reductase activity
EAH52_RS09785	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EAH52_RS09795	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EAH52_RS09800	COG0556	nucleotide-excision repair
EAH52_RS09815	COG3942	CHAP domain
EAH52_RS09815	COG1388	LysM domain
EAH52_RS09825	COG0653	protein targeting
EAH52_RS09830	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EAH52_RS09835	COG1040	competence protein
EAH52_RS09840	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
EAH52_RS09850	COG1739	Uncharacterized protein family UPF0029
EAH52_RS09855	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EAH52_RS09875	COG2195	Cleaves the N-terminal amino acid of tripeptides
EAH52_RS09880	COG1929	Belongs to the glycerate kinase type-1 family
EAH52_RS09900	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EAH52_RS09915	COG4604	ABC transporter, ATP-binding protein
EAH52_RS09920	COG4605	iron ion homeostasis
EAH52_RS09925	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EAH52_RS09930	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EAH52_RS09935	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EAH52_RS09940	COG1780	Probably involved in ribonucleotide reductase function
EAH52_RS09955	COG3104	oligopeptide transport
EAH52_RS09960	COG1597	lipid kinase activity
EAH52_RS09970	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EAH52_RS09975	COG1174	glycine betaine transport
EAH52_RS09980	COG1125	glycine betaine transport
EAH52_RS09980	COG0517	IMP dehydrogenase activity
EAH52_RS09985	COG0514	ATP-dependent DNA helicase (RecQ)
EAH52_RS09990	COG0488	(ABC) transporter
EAH52_RS10000	COG1368	sulfuric ester hydrolase activity
EAH52_RS10030	COG0512	Glutamine amidotransferase of anthranilate synthase
EAH52_RS10030	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EAH52_RS10035	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EAH52_RS10040	COG0720	synthase
EAH52_RS10045	COG0602	queuosine metabolic process
EAH52_RS10055	COG0463	Glycosyl transferase, family 2
EAH52_RS10060	COG0656	L-ascorbic acid biosynthetic process
EAH52_RS10065	COG1253	flavin adenine dinucleotide binding
EAH52_RS10070	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EAH52_RS10075	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EAH52_RS10075	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EAH52_RS10075	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EAH52_RS10080	COG1105	Belongs to the carbohydrate kinase PfkB family
EAH52_RS10085	COG1349	DNA-binding transcription factor activity
EAH52_RS10090	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EAH52_RS10115	COG0415	Belongs to the DNA photolyase family
EAH52_RS10120	COG0471	metal ion transport
EAH52_RS10125	COG0039	L-malate dehydrogenase activity
EAH52_RS10135	COG4989	oxidoreductase activity
EAH52_RS10140	COG0523	cobalamin synthesis protein
EAH52_RS10150	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EAH52_RS10155	COG4988	ABC transporter
EAH52_RS10160	COG1968	undecaprenyl-diphosphatase activity
EAH52_RS10170	COG1671	Belongs to the UPF0178 family
EAH52_RS10175	COG1611	Belongs to the LOG family
EAH52_RS10185	COG1959	2 iron, 2 sulfur cluster binding
EAH52_RS10195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EAH52_RS10220	COG2839	Protein conserved in bacteria
EAH52_RS10225	COG2814	Major facilitator Superfamily
EAH52_RS10230	COG0583	DNA-binding transcription factor activity
EAH52_RS10245	COG0217	transcriptional regulatory protein
EAH52_RS10255	COG2207	Transcriptional regulator
EAH52_RS10255	COG0662	Cupin 2, conserved barrel domain protein
EAH52_RS10265	COG3942	CHAP domain
EAH52_RS10265	COG1388	LysM domain
EAH52_RS10275	COG0306	phosphate transporter
EAH52_RS10280	COG1392	Phosphate transport regulator
EAH52_RS10290	COG0577	efflux transmembrane transporter activity
EAH52_RS10295	COG1136	(ABC) transporter
EAH52_RS10300	COG2205	protein histidine kinase activity
EAH52_RS10310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EAH52_RS10320	COG0657	acetylesterase activity
EAH52_RS10325	COG3949	Membrane
EAH52_RS10335	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
EAH52_RS10345	COG2376	Dihydroxyacetone kinase
EAH52_RS10350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EAH52_RS10355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EAH52_RS10360	COG1120	ATPase activity
EAH52_RS10365	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EAH52_RS10370	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EAH52_RS10375	COG1132	(ABC) transporter
EAH52_RS10380	COG1686	Belongs to the peptidase S11 family
EAH52_RS10385	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EAH52_RS10395	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EAH52_RS10400	COG1682	transport, permease protein
EAH52_RS10405	COG1134	teichoic acid transport
EAH52_RS10410	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
EAH52_RS10425	COG1121	(ABC) transporter
EAH52_RS10430	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EAH52_RS10435	COG0803	Belongs to the bacterial solute-binding protein 9 family
EAH52_RS10445	COG1320	monovalent cation:proton antiporter activity
EAH52_RS10455	COG1863	multisubunit Na H antiporter MnhE subunit
EAH52_RS10460	COG0651	ATP synthesis coupled electron transport
EAH52_RS10465	COG1006	Multisubunit Na H antiporter MnhC subunit
EAH52_RS10470	COG2111	Na H antiporter
EAH52_RS10475	COG2111	Na H antiporter
EAH52_RS10475	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EAH52_RS10510	COG2267	carboxylic ester hydrolase activity
EAH52_RS10530	COG0546	phosphoglycolate phosphatase activity
EAH52_RS10535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EAH52_RS10540	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EAH52_RS10545	COG0534	Mate efflux family protein
EAH52_RS10555	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EAH52_RS10560	COG0018	arginyl-trna synthetase
EAH52_RS10585	COG1078	dGTPase activity
EAH52_RS10595	COG0655	NAD(P)H dehydrogenase (quinone) activity
EAH52_RS10600	COG0667	Aldo Keto reductase
EAH52_RS10605	COG4844	belongs to the
EAH52_RS10620	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EAH52_RS10625	COG0095	Lipoate-protein ligase
EAH52_RS10630	COG0280	phosphate acetyltransferase
EAH52_RS10635	COG3253	May function as heme-dependent peroxidase
EAH52_RS10655	COG2363	Small membrane protein
EAH52_RS10670	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
EAH52_RS10690	COG0477	Major facilitator Superfamily
EAH52_RS10705	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
EAH52_RS10710	COG0363	glucosamine-6-phosphate deaminase activity
EAH52_RS10720	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EAH52_RS10725	COG1469	GTP cyclohydrolase I activity
EAH52_RS10730	COG2271	Major facilitator Superfamily
EAH52_RS10755	COG0431	NADPH-dependent FMN reductase
EAH52_RS10760	COG0561	phosphatase activity
EAH52_RS10770	COG1428	Deoxynucleoside kinase
EAH52_RS10775	COG1428	Deoxynucleoside kinase
EAH52_RS10780	COG0546	phosphoglycolate phosphatase activity
EAH52_RS10785	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EAH52_RS10795	COG0737	Belongs to the 5'-nucleotidase family
EAH52_RS10810	COG1063	alcohol dehydrogenase
EAH52_RS10815	COG2814	Major facilitator Superfamily
EAH52_RS10820	COG1349	DNA-binding transcription factor activity
EAH52_RS10845	COG1473	amidohydrolase
EAH52_RS10850	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EAH52_RS10855	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EAH52_RS10860	COG0049	tRNA binding
EAH52_RS10865	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EAH52_RS10875	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EAH52_RS10880	COG0085	RNA polymerase activity
EAH52_RS10885	COG2813	Specifically methylates the guanine in position
EAH52_RS10890	COG0222	ribosome binding
EAH52_RS10895	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EAH52_RS10905	COG0081	regulation of translation
EAH52_RS10910	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EAH52_RS10915	COG0250	Participates in transcription elongation, termination and antitermination
EAH52_RS10925	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EAH52_RS10935	COG3688	RNA-binding protein containing a PIN domain
EAH52_RS10945	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
EAH52_RS10950	COG0215	cysteine-tRNA ligase activity
EAH52_RS10960	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EAH52_RS10965	COG4956	integral membrane protein (PIN domain superfamily)
EAH52_RS10970	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EAH52_RS10975	COG0542	response to heat
EAH52_RS10980	COG3869	Catalyzes the specific phosphorylation of arginine residues in
EAH52_RS10985	COG3880	PFAM UvrB UvrC protein
EAH52_RS10995	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EAH52_RS11000	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
EAH52_RS11005	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
EAH52_RS11010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EAH52_RS11080	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EAH52_RS11085	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EAH52_RS11090	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EAH52_RS11110	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EAH52_RS11125	COG1098	S1 RNA binding domain
EAH52_RS11135	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EAH52_RS11140	COG3956	TIGRFAM MazG family protein
EAH52_RS11145	COG2244	polysaccharide biosynthetic process
EAH52_RS11150	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EAH52_RS11155	COG0193	aminoacyl-tRNA hydrolase activity
EAH52_RS11160	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EAH52_RS11165	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EAH52_RS11170	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EAH52_RS11175	COG2088	sporulation resulting in formation of a cellular spore
EAH52_RS11180	COG0251	oxidation-reduction process
EAH52_RS11185	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EAH52_RS11190	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EAH52_RS11195	COG4466	Protein conserved in bacteria
EAH52_RS11200	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EAH52_RS11205	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EAH52_RS11210	COG0084	hydrolase, TatD family'
EAH52_RS11215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EAH52_RS11215	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EAH52_RS11220	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EAH52_RS11225	COG2827	Endonuclease containing a URI domain
EAH52_RS11230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EAH52_RS11235	COG4467	Involved in initiation control of chromosome replication
EAH52_RS11240	COG1774	PSP1 C-terminal conserved region
EAH52_RS11245	COG0470	DNA polymerase III
EAH52_RS11250	COG3870	Protein conserved in bacteria
EAH52_RS11260	COG1982	Orn Lys Arg decarboxylase major
EAH52_RS11265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EAH52_RS11285	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EAH52_RS11290	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EAH52_RS11295	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EAH52_RS11310	COG2188	Transcriptional regulator
EAH52_RS11315	COG0366	Alpha amylase catalytic
EAH52_RS11320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EAH52_RS11320	COG1263	PTS System
EAH52_RS11330	COG0493	'glutamate synthase
EAH52_RS11335	COG0070	glutamate synthase
EAH52_RS11335	COG0067	glutamate synthase
EAH52_RS11335	COG0069	glutamate synthase activity
EAH52_RS11355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EAH52_RS11360	COG0494	nUDIX hydrolase
EAH52_RS11370	COG0438	transferase activity, transferring glycosyl groups
EAH52_RS11385	COG1278	Cold shock
EAH52_RS11390	COG3759	membrane
EAH52_RS11415	COG1846	Transcriptional regulator
EAH52_RS11420	COG0626	cystathionine gamma-synthase activity
EAH52_RS11425	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EAH52_RS11440	COG1279	arginine transmembrane transporter activity
EAH52_RS11445	COG0733	neurotransmitter:sodium symporter activity
EAH52_RS11455	COG1647	Serine aminopeptidase, S33
EAH52_RS11460	COG0671	phosphoesterase, PA-phosphatase related
EAH52_RS11475	COG5609	conserved protein (DUF2294)
EAH52_RS11480	COG3002	Belongs to the UPF0753 family
EAH52_RS11485	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EAH52_RS11500	COG0523	cobalamin synthesis protein
EAH52_RS11510	COG0519	Catalyzes the synthesis of GMP from XMP
EAH52_RS11510	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EAH52_RS11515	COG0517	IMP dehydrogenase activity
EAH52_RS11515	COG0516	GMP reductase activity
EAH52_RS11520	COG2233	PERMEase
EAH52_RS11525	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EAH52_RS11540	COG5183	chlorophyll binding
EAH52_RS11550	COG1823	symporter activity
EAH52_RS11555	COG0778	Nitroreductase
EAH52_RS11560	COG0450	alkyl hydroperoxide reductase
EAH52_RS11565	COG3634	alkyl hydroperoxide reductase activity
EAH52_RS11590	COG1280	lysine exporter protein (LysE YggA)
EAH52_RS11610	COG3728	DNA packaging
EAH52_RS11610	COG5484	DNA packaging
EAH52_RS11695	COG0582	viral genome integration into host DNA
EAH52_RS11700	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EAH52_RS11710	COG0360	Binds together with S18 to 16S ribosomal RNA
EAH52_RS11725	COG0012	GTP binding
EAH52_RS11730	COG4481	Protein conserved in bacteria
EAH52_RS11735	COG0668	transmembrane transport
EAH52_RS11740	COG1475	DNA binding
EAH52_RS11750	COG0626	cystathionine gamma-synthase activity
EAH52_RS11755	COG0626	cystathionine gamma-synthase activity
EAH52_RS11760	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EAH52_RS11760	COG0646	methionine synthase
EAH52_RS11765	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EAH52_RS11785	COG3942	CHAP domain
EAH52_RS11795	COG0183	Belongs to the thiolase family
EAH52_RS11800	COG3250	beta-galactosidase activity
EAH52_RS11805	COG1028	Short-chain dehydrogenase reductase Sdr
EAH52_RS11810	COG1312	Catalyzes the dehydration of D-mannonate
EAH52_RS11815	COG1904	glucuronate isomerase
EAH52_RS11820	COG2211	Major facilitator Superfamily
EAH52_RS11825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EAH52_RS11830	COG0800	Aldolase
EAH52_RS11835	COG2207	Transcriptional regulator
EAH52_RS11880	COG1476	TRANSCRIPTIONal
EAH52_RS11890	COG1131	(ABC) transporter
EAH52_RS11905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EAH52_RS11925	COG1136	(ABC) transporter
EAH52_RS11930	COG0577	efflux transmembrane transporter activity
EAH52_RS12010	COG2348	transferase activity, transferring amino-acyl groups
EAH52_RS12020	COG1063	alcohol dehydrogenase
EAH52_RS12025	COG0577	efflux transmembrane transporter activity
EAH52_RS12030	COG1136	(ABC) transporter
EAH52_RS12070	COG1475	DNA binding
EAH52_RS12075	COG0357	Ribosomal RNA small subunit methyltransferase G
EAH52_RS12080	COG0445	tRNA wobble uridine modification
EAH52_RS12085	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EAH52_RS12090	COG0594	ribonuclease P activity
EAH52_RS12350	COG1132	(ABC) transporter
EAH52_RS12465	COG1131	(ABC) transporter
EAH52_RS12480	COG1192	Involved in chromosome partitioning
EAH52_RS12540	COG2217	Heavy metal translocating P-type atpase
EAH52_RS12545	COG1937	Protein conserved in bacteria
EAH52_RS12555	COG1230	cation diffusion facilitator family transporter
EAH52_RS12615	COG3682	Transcriptional regulator
EAH52_RS12700	COG4282	regulation of fungal-type cell wall biogenesis
EAH52_RS12735	COG0640	Transcriptional regulator
EAH52_RS12760	COG1511	domain protein