locus-tag	class	description
IAR39_RS00015	COG0116	Belongs to the methyltransferase superfamily
IAR39_RS00025	COG3599	regulation of cell shape
IAR39_RS00040	COG3331	DNA recombination
IAR39_RS00045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IAR39_RS00045	COG4499	WXG100 protein secretion system (Wss), protein YukC
IAR39_RS00055	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IAR39_RS00060	COG3935	DnaD domain protein
IAR39_RS00065	COG0017	Asparaginyl-tRNA synthetase
IAR39_RS00070	COG1199	ATP-dependent helicase activity
IAR39_RS00070	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IAR39_RS00075	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IAR39_RS00075	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IAR39_RS00080	COG0617	tRNA 3'-terminal CCA addition
IAR39_RS00085	COG0438	transferase activity, transferring glycosyl groups
IAR39_RS00090	COG1694	Mazg nucleotide pyrophosphohydrolase
IAR39_RS00095	COG2738	Putative neutral zinc metallopeptidase
IAR39_RS00100	COG4347	Protein of unknown function (DUF1405)
IAR39_RS00105	COG5582	Belongs to the UPF0302 family
IAR39_RS00120	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IAR39_RS00125	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IAR39_RS00140	COG2226	methyltransferase
IAR39_RS00155	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IAR39_RS00160	COG1160	GTP binding
IAR39_RS00165	COG0539	negative regulation of cytoplasmic translation
IAR39_RS00170	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IAR39_RS00180	COG0492	ferredoxin-NADP+ reductase activity
IAR39_RS00190	COG0514	ATP-dependent DNA helicase (RecQ)
IAR39_RS00200	COG1141	Ferredoxin
IAR39_RS00215	COG0745	RESPONSE REGULATOR receiver
IAR39_RS00220	COG1187	pseudouridine synthase activity
IAR39_RS00225	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IAR39_RS00230	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IAR39_RS00240	COG4974	Belongs to the 'phage' integrase family
IAR39_RS00245	COG0735	belongs to the Fur family
IAR39_RS00250	COG0494	nUDIX hydrolase
IAR39_RS00255	COG0667	Aldo Keto reductase
IAR39_RS00260	COG1028	Short-chain dehydrogenase reductase Sdr
IAR39_RS00265	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IAR39_RS00270	COG1234	tRNA 3'-trailer cleavage
IAR39_RS00275	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IAR39_RS00285	COG0366	Alpha amylase catalytic
IAR39_RS00290	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IAR39_RS00295	COG2195	Cleaves the N-terminal amino acid of tripeptides
IAR39_RS00310	COG0508	dehydrogenase complex catalyzes the overall conversion of
IAR39_RS00315	COG0022	dehydrogenase e1 component
IAR39_RS00320	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IAR39_RS00325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IAR39_RS00330	COG0497	DNA recombination
IAR39_RS00335	COG1438	arginine binding
IAR39_RS00340	COG0142	geranyltranstransferase activity
IAR39_RS00345	COG1722	exodeoxyribonuclease VII activity
IAR39_RS00355	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IAR39_RS00360	COG1302	Protein conserved in bacteria
IAR39_RS00365	COG0439	Biotin carboxylase
IAR39_RS00370	COG0511	ligase activity, forming carbon-carbon bonds
IAR39_RS00375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IAR39_RS00380	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IAR39_RS00385	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IAR39_RS00390	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IAR39_RS00395	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IAR39_RS00400	COG0006	proline dipeptidase activity
IAR39_RS00415	COG0095	Lipoate-protein ligase
IAR39_RS00420	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IAR39_RS00435	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IAR39_RS00440	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IAR39_RS00450	COG4537	Required for transformation and DNA binding
IAR39_RS00455	COG1459	type II secretion system
IAR39_RS00460	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IAR39_RS00465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IAR39_RS00470	COG0011	TIGRFAM Protein of
IAR39_RS00475	COG1940	carbohydrate kinase activity
IAR39_RS00480	COG4483	Protein conserved in bacteria
IAR39_RS00490	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IAR39_RS00495	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IAR39_RS00500	COG0768	penicillin binding
IAR39_RS00515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IAR39_RS00520	COG1121	(ABC) transporter
IAR39_RS00525	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IAR39_RS00530	COG0513	Belongs to the DEAD box helicase family
IAR39_RS00535	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IAR39_RS00540	COG2384	SAM-dependent methyltransferase
IAR39_RS00545	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IAR39_RS00555	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IAR39_RS00560	COG0517	IMP dehydrogenase activity
IAR39_RS00565	COG0423	glycine-tRNA ligase activity
IAR39_RS00570	COG1381	Involved in DNA repair and RecF pathway recombination
IAR39_RS00575	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IAR39_RS00595	COG1702	phosphate starvation-inducible protein PhoH
IAR39_RS00605	COG4864	UPF0365 protein
IAR39_RS00610	COG1030	water channel activity
IAR39_RS00620	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IAR39_RS00625	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IAR39_RS00635	COG0484	heat shock protein binding
IAR39_RS00640	COG0443	Heat shock 70 kDa protein
IAR39_RS00645	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IAR39_RS00655	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IAR39_RS00660	COG0481	GTPase activity
IAR39_RS00665	COG0268	Binds directly to 16S ribosomal RNA
IAR39_RS00670	COG1466	dna polymerase III delta subunit
IAR39_RS00675	COG0658	competence protein
IAR39_RS00675	COG2333	competence protein COMEC
IAR39_RS00680	COG2131	deaminase
IAR39_RS00685	COG1596	polysaccharide export
IAR39_RS00685	COG1555	photosystem II stabilization
IAR39_RS00695	COG0799	negative regulation of ribosome biogenesis
IAR39_RS00700	COG1713	HD superfamily hydrolase involved in NAD metabolism
IAR39_RS00705	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IAR39_RS00710	COG1534	Rna-binding protein
IAR39_RS00715	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IAR39_RS00720	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IAR39_RS00725	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
IAR39_RS00730	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IAR39_RS00735	COG1914	H( )-stimulated, divalent metal cation uptake system
IAR39_RS00745	COG0439	Biotin carboxylase
IAR39_RS00750	COG0511	ligase activity, forming carbon-carbon bonds
IAR39_RS00755	COG1984	allophanate hydrolase subunit 2
IAR39_RS00760	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IAR39_RS00765	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IAR39_RS00770	COG0572	uridine kinase
IAR39_RS00775	COG0826	peptidase U32
IAR39_RS00780	COG0826	peptidase U32
IAR39_RS00785	COG4122	O-methyltransferase activity
IAR39_RS00790	COG3906	Belongs to the UPF0473 family
IAR39_RS00795	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IAR39_RS00800	COG4472	Bacterial protein of unknown function (DUF965)
IAR39_RS00810	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IAR39_RS00820	COG0482	sulfurtransferase activity
IAR39_RS00825	COG1104	cysteine desulfurase activity
IAR39_RS00830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAR39_RS00840	COG1959	2 iron, 2 sulfur cluster binding
IAR39_RS00845	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IAR39_RS00850	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IAR39_RS00860	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IAR39_RS00870	COG0860	N-Acetylmuramoyl-L-alanine amidase
IAR39_RS00880	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IAR39_RS00890	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IAR39_RS00890	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IAR39_RS00895	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IAR39_RS00895	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IAR39_RS00900	COG1862	Preprotein translocase
IAR39_RS00910	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IAR39_RS00920	COG0632	four-way junction helicase activity
IAR39_RS00925	COG4492	Belongs to the UPF0735 family
IAR39_RS00930	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IAR39_RS00935	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IAR39_RS00940	COG2868	ribosomal protein
IAR39_RS00945	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IAR39_RS00980	COG2003	Belongs to the UPF0758 family
IAR39_RS00990	COG0285	dihydrofolate synthase activity
IAR39_RS01000	COG2818	Glycosylase
IAR39_RS01010	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IAR39_RS01030	COG0181	hydroxymethylbilane synthase activity
IAR39_RS01040	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IAR39_RS01045	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IAR39_RS01050	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IAR39_RS01055	COG0544	peptidyl-prolyl cis-trans isomerase activity
IAR39_RS01065	COG4112	unkown
IAR39_RS01070	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IAR39_RS01075	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IAR39_RS01080	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IAR39_RS01085	COG0833	amino acid
IAR39_RS01095	COG1484	DNA-dependent DNA replication
IAR39_RS01100	COG3611	Membrane attachment protein
IAR39_RS01105	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IAR39_RS01110	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IAR39_RS01120	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IAR39_RS01125	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IAR39_RS01125	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IAR39_RS01130	COG5002	protein histidine kinase activity
IAR39_RS01135	COG0745	RESPONSE REGULATOR receiver
IAR39_RS01140	COG0538	isocitrate dehydrogenase activity
IAR39_RS01145	COG0372	Belongs to the citrate synthase family
IAR39_RS01150	COG1113	amino acid transport
IAR39_RS01155	COG0469	pyruvate kinase activity
IAR39_RS01160	COG0205	6-phosphofructokinase activity
IAR39_RS01170	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IAR39_RS01175	COG0281	malic enzyme
IAR39_RS01180	COG0587	DNA-directed DNA polymerase activity
IAR39_RS01185	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IAR39_RS01190	COG4109	DRTGG domain
IAR39_RS01200	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IAR39_RS01205	COG0006	proline dipeptidase activity
IAR39_RS01210	COG0686	Belongs to the AlaDH PNT family
IAR39_RS01215	COG0589	response to stress
IAR39_RS01220	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IAR39_RS01225	COG0827	DNA restriction-modification system
IAR39_RS01230	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IAR39_RS01240	COG0301	tRNA thio-modification
IAR39_RS01245	COG1104	cysteine desulfurase activity
IAR39_RS01250	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
IAR39_RS01255	COG1956	GAF domain-containing protein
IAR39_RS01260	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IAR39_RS01265	COG0584	glycerophosphoryl diester phosphodiesterase
IAR39_RS01270	COG1764	response to oxidative stress
IAR39_RS01275	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IAR39_RS01280	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IAR39_RS01290	COG1263	PTS System
IAR39_RS01290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IAR39_RS01310	COG0204	Acyl-transferase
IAR39_RS01315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IAR39_RS01335	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IAR39_RS01345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IAR39_RS01350	COG0454	-acetyltransferase
IAR39_RS01360	COG1609	Transcriptional regulator
IAR39_RS01365	COG1605	Chorismate mutase
IAR39_RS01365	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IAR39_RS01380	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IAR39_RS01385	COG1674	ftsk spoiiie
IAR39_RS01390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IAR39_RS01395	COG4848	Belongs to the UPF0354 family
IAR39_RS01400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IAR39_RS01405	COG1363	Peptidase, m42
IAR39_RS01415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IAR39_RS01420	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IAR39_RS01425	COG0510	thiamine kinase activity
IAR39_RS01430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IAR39_RS01435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IAR39_RS01445	COG1187	pseudouridine synthase activity
IAR39_RS01450	COG2244	polysaccharide biosynthetic process
IAR39_RS01455	COG2081	HI0933 family
IAR39_RS01470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IAR39_RS01475	COG0495	leucyl-tRNA aminoacylation
IAR39_RS01480	COG2814	Major facilitator Superfamily
IAR39_RS01485	COG1242	4 iron, 4 sulfur cluster binding
IAR39_RS01490	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
IAR39_RS01500	COG2267	carboxylic ester hydrolase activity
IAR39_RS01510	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IAR39_RS01515	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IAR39_RS01515	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IAR39_RS01520	COG0307	riboflavin synthase, alpha
IAR39_RS01525	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IAR39_RS01525	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IAR39_RS01535	COG3266	domain, Protein
IAR39_RS01535	COG4193	domain, Protein
IAR39_RS01535	COG5632	N-Acetylmuramoyl-L-alanine amidase
IAR39_RS01560	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IAR39_RS01570	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IAR39_RS01575	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IAR39_RS01580	COG0656	L-ascorbic acid biosynthetic process
IAR39_RS01590	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IAR39_RS01600	COG1506	peptidase
IAR39_RS01605	COG0494	nUDIX hydrolase
IAR39_RS01620	COG0318	PFAM AMP-dependent synthetase and ligase
IAR39_RS01670	COG3545	Serine hydrolase
IAR39_RS01675	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IAR39_RS01680	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IAR39_RS01690	COG2329	Antibiotic biosynthesis monooxygenase
IAR39_RS01695	COG4473	ABC transporter
IAR39_RS01700	COG1131	(ABC) transporter
IAR39_RS01705	COG0537	adenosine 5'-monophosphoramidase activity
IAR39_RS01720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IAR39_RS01730	COG3481	metal-dependent phosphohydrolase, HD sub domain
IAR39_RS01740	COG0420	3'-5' exonuclease activity
IAR39_RS01745	COG3679	Belongs to the UPF0342 family
IAR39_RS01750	COG4399	Belongs to the UPF0754 family
IAR39_RS01760	COG2197	response regulator
IAR39_RS01765	COG2203	Gaf domain
IAR39_RS01765	COG4585	Histidine kinase
IAR39_RS01770	COG0564	pseudouridine synthase activity
IAR39_RS01775	COG0114	fumarate hydratase activity
IAR39_RS01790	COG0363	glucosamine-6-phosphate deaminase activity
IAR39_RS01800	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IAR39_RS01805	COG1126	abc transporter atp-binding protein
IAR39_RS01810	COG0765	amino acid transport
IAR39_RS01985	COG0735	belongs to the Fur family
IAR39_RS01990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IAR39_RS01995	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IAR39_RS02000	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IAR39_RS02005	COG4129	membrane
IAR39_RS02015	COG3557	Belongs to the UPF0374 family
IAR39_RS02020	COG1194	a g-specific adenine glycosylase
IAR39_RS02025	COG1988	membrane-bound metal-dependent
IAR39_RS02035	COG1388	LysM domain
IAR39_RS02035	COG1134	teichoic acid transport
IAR39_RS02050	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IAR39_RS02055	COG0693	protein deglycase activity
IAR39_RS02065	COG0535	radical SAM domain protein
IAR39_RS02075	COG2309	aminopeptidase activity
IAR39_RS02080	COG4840	Belongs to the UPF0435 family
IAR39_RS02095	COG1295	ribonuclease BN
IAR39_RS02100	COG2197	response regulator
IAR39_RS02120	COG0024	Methionine aminopeptidase
IAR39_RS02125	COG4129	membrane
IAR39_RS02140	COG1528	Iron-storage protein
IAR39_RS02160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IAR39_RS02165	COG1597	lipid kinase activity
IAR39_RS02170	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IAR39_RS02185	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IAR39_RS02195	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IAR39_RS02200	COG0210	DNA helicase
IAR39_RS02205	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
IAR39_RS02210	COG4496	protein, YerC YecD
IAR39_RS02215	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IAR39_RS02225	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
IAR39_RS02230	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IAR39_RS02235	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IAR39_RS02245	COG0077	Prephenate dehydratase
IAR39_RS02255	COG1335	isochorismatase
IAR39_RS02260	COG1227	inorganic diphosphatase activity
IAR39_RS02265	COG1012	belongs to the aldehyde dehydrogenase family
IAR39_RS02270	COG2706	6-phosphogluconolactonase activity
IAR39_RS02315	COG1131	(ABC) transporter
IAR39_RS02330	COG1725	Transcriptional regulator
IAR39_RS02355	COG0459	protein refolding
IAR39_RS02360	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IAR39_RS02405	COG3290	protein histidine kinase activity
IAR39_RS02415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IAR39_RS02420	COG1621	beta-fructofuranosidase activity
IAR39_RS02425	COG1609	Transcriptional regulator
IAR39_RS02430	COG0425	Belongs to the sulfur carrier protein TusA family
IAR39_RS02435	COG2391	methyltransferase activity
IAR39_RS02450	COG0488	(ABC) transporter
IAR39_RS02455	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IAR39_RS02460	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IAR39_RS02465	COG0456	acetyltransferase
IAR39_RS02470	COG1214	PFAM Peptidase M22, glycoprotease
IAR39_RS02475	COG0802	atpase or kinase
IAR39_RS02480	COG0129	dihydroxy-acid dehydratase activity
IAR39_RS02485	COG0028	Belongs to the TPP enzyme family
IAR39_RS02505	COG0473	3-isopropylmalate dehydrogenase activity
IAR39_RS02510	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IAR39_RS02555	COG2183	response to ionizing radiation
IAR39_RS02560	COG1191	sigma factor activity
IAR39_RS02575	COG2208	phosphoserine phosphatase activity
IAR39_RS02580	COG2337	Toxic component of a toxin-antitoxin (TA) module
IAR39_RS02590	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IAR39_RS02595	COG0736	holo-[acyl-carrier-protein] synthase activity
IAR39_RS02605	COG3428	Bacterial PH domain
IAR39_RS02615	COG0513	Belongs to the DEAD box helicase family
IAR39_RS02620	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IAR39_RS02625	COG1181	Belongs to the D-alanine--D-alanine ligase family
IAR39_RS02630	COG0772	Belongs to the SEDS family
IAR39_RS02645	COG1937	Protein conserved in bacteria
IAR39_RS02650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IAR39_RS02655	COG1418	mRNA catabolic process
IAR39_RS02660	COG0706	membrane insertase activity
IAR39_RS02665	COG0352	thiamine-phosphate diphosphorylase activity
IAR39_RS02670	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
IAR39_RS02680	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IAR39_RS02705	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IAR39_RS02720	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IAR39_RS02725	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IAR39_RS02730	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IAR39_RS02740	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IAR39_RS02765	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IAR39_RS02770	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IAR39_RS02780	COG4475	Protein of unknown function (DUF436)
IAR39_RS02785	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IAR39_RS02790	COG0009	L-threonylcarbamoyladenylate synthase
IAR39_RS02795	COG2890	protein-(glutamine-N5) methyltransferase activity
IAR39_RS02805	COG1435	thymidine kinase activity
IAR39_RS02810	COG0254	rRNA binding
IAR39_RS02815	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IAR39_RS02820	COG1012	belongs to the aldehyde dehydrogenase family
IAR39_RS02830	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IAR39_RS02835	COG0191	fructose-bisphosphate aldolase activity
IAR39_RS02845	COG0504	CTP synthase activity
IAR39_RS02860	COG5146	pantothenate kinase activity
IAR39_RS02880	COG1854	S-ribosylhomocysteine lyase activity
IAR39_RS02890	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IAR39_RS02895	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IAR39_RS02900	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IAR39_RS02905	COG0813	purine-nucleoside phosphorylase activity
IAR39_RS02910	COG0783	Belongs to the Dps family
IAR39_RS02930	COG1482	cell wall glycoprotein biosynthetic process
IAR39_RS02935	COG0702	epimerase
IAR39_RS02940	COG0640	Transcriptional regulator
IAR39_RS02960	COG0561	phosphatase activity
IAR39_RS02975	COG3711	transcriptional antiterminator
IAR39_RS03000	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
IAR39_RS03055	COG0489	protein tyrosine kinase activity
IAR39_RS03060	COG2814	Major facilitator Superfamily
IAR39_RS03075	COG1272	protein, Hemolysin III
IAR39_RS03080	COG4284	Utp--glucose-1-phosphate uridylyltransferase
IAR39_RS03085	COG1988	membrane-bound metal-dependent
IAR39_RS03095	COG2329	Antibiotic biosynthesis monooxygenase
IAR39_RS03100	COG3314	Sporulation integral membrane protein YlbJ
IAR39_RS03105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAR39_RS03110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAR39_RS03115	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
IAR39_RS03120	COG3457	Alanine racemase
IAR39_RS03125	COG4264	IucA IucC family
IAR39_RS03130	COG2814	Major facilitator Superfamily
IAR39_RS03140	COG1302	Protein conserved in bacteria
IAR39_RS03155	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IAR39_RS03160	COG0604	alcohol dehydrogenase
IAR39_RS03165	COG2130	NADP-dependent
IAR39_RS03170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAR39_RS03190	COG5632	N-Acetylmuramoyl-L-alanine amidase
IAR39_RS03190	COG1388	LysM domain
IAR39_RS03355	COG0756	dUTP diphosphatase activity
IAR39_RS03410	COG0305	Participates in initiation and elongation during chromosome replication
IAR39_RS03505	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IAR39_RS03535	COG0698	ribose 5-phosphate isomerase
IAR39_RS03555	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IAR39_RS03570	COG1122	ATPase activity
IAR39_RS03585	COG0202	RNA polymerase activity
IAR39_RS03590	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IAR39_RS03595	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IAR39_RS03605	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IAR39_RS03610	COG0563	adenylate kinase activity
IAR39_RS03615	COG0201	protein transport
IAR39_RS03625	COG1841	ribosomal large subunit assembly
IAR39_RS03630	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IAR39_RS03635	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IAR39_RS03640	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IAR39_RS03645	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IAR39_RS03650	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IAR39_RS03660	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IAR39_RS03665	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IAR39_RS03670	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IAR39_RS03680	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IAR39_RS03685	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IAR39_RS03690	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IAR39_RS03695	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IAR39_RS03700	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IAR39_RS03705	COG0089	rRNA binding
IAR39_RS03710	COG0088	Forms part of the polypeptide exit tunnel
IAR39_RS03715	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IAR39_RS03730	COG2252	PERMEase
IAR39_RS03745	COG4975	Glucose uptake
IAR39_RS03770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IAR39_RS03775	COG2348	transferase activity, transferring amino-acyl groups
IAR39_RS03790	COG2814	Major facilitator Superfamily
IAR39_RS03800	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IAR39_RS03820	COG1763	Mo-molybdopterin cofactor biosynthetic process
IAR39_RS03830	COG0315	cyclic pyranopterin monophosphate synthase activity
IAR39_RS03835	COG0521	Mo-molybdopterin cofactor biosynthetic process
IAR39_RS03840	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IAR39_RS03845	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IAR39_RS03850	COG4149	molybdate abc transporter
IAR39_RS03855	COG0725	ABC transporter, periplasmic molybdate-binding protein
IAR39_RS03860	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IAR39_RS03870	COG1268	BioY protein
IAR39_RS03885	COG1960	acyl-CoA dehydrogenase activity
IAR39_RS03890	COG1126	abc transporter atp-binding protein
IAR39_RS03895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IAR39_RS03900	COG0765	amino acid transport
IAR39_RS03905	COG0765	amino acid transport
IAR39_RS03910	COG4413	Urea transporter
IAR39_RS03915	COG0831	urea catabolic process
IAR39_RS03925	COG0804	urea catabolic process
IAR39_RS03930	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
IAR39_RS03945	COG0829	nickel cation binding
IAR39_RS03960	COG1846	Transcriptional regulator
IAR39_RS03970	COG3942	CHAP domain
IAR39_RS03975	COG1757	Na H antiporter
IAR39_RS03990	COG3942	CHAP domain
IAR39_RS03995	COG2076	Multidrug Resistance protein
IAR39_RS04000	COG2076	Multidrug Resistance protein
IAR39_RS04005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IAR39_RS04035	COG1316	TRANSCRIPTIONal
IAR39_RS04045	COG2378	regulation of single-species biofilm formation
IAR39_RS04050	COG1266	CAAX protease self-immunity
IAR39_RS04065	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IAR39_RS04070	COG1263	PTS System
IAR39_RS04070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IAR39_RS04080	COG1113	amino acid transport
IAR39_RS04100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IAR39_RS04105	COG0385	Bile acid
IAR39_RS04115	COG1263	PTS System
IAR39_RS04115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IAR39_RS04120	COG1737	Transcriptional regulator
IAR39_RS04140	COG1028	Short-chain dehydrogenase reductase Sdr
IAR39_RS04145	COG1473	amidohydrolase
IAR39_RS04165	COG0583	DNA-binding transcription factor activity
IAR39_RS04170	COG0010	Belongs to the arginase family
IAR39_RS04175	COG1266	CAAX protease self-immunity
IAR39_RS04185	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IAR39_RS04195	COG2017	converts alpha-aldose to the beta-anomer
IAR39_RS04200	COG1742	UPF0060 membrane protein
IAR39_RS04205	COG1668	transmembrane transport
IAR39_RS04210	COG4152	abc transporter atp-binding protein
IAR39_RS04215	COG1069	ribulokinase activity
IAR39_RS04225	COG3620	sequence-specific DNA binding
IAR39_RS04235	COG2094	Belongs to the DNA glycosylase MPG family
IAR39_RS04250	COG1695	Transcriptional regulator
IAR39_RS04255	COG0786	glutamate:sodium symporter activity
IAR39_RS04260	COG1304	FMN binding
IAR39_RS04265	COG0598	Magnesium transport protein CorA
IAR39_RS04290	COG2814	Major facilitator Superfamily
IAR39_RS04295	COG1566	PFAM secretion protein HlyD family protein
IAR39_RS04305	COG2814	Major facilitator Superfamily
IAR39_RS04330	COG0577	efflux transmembrane transporter activity
IAR39_RS04355	COG0579	oxidoreductase
IAR39_RS04360	COG0438	transferase activity, transferring glycosyl groups
IAR39_RS04365	COG1620	l-lactate permease
IAR39_RS04370	COG0463	Glycosyl transferase, family 2
IAR39_RS04370	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IAR39_RS04380	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IAR39_RS04380	COG0463	Glycosyl transferase, family 2
IAR39_RS04390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IAR39_RS04395	COG0805	protein transport
IAR39_RS04400	COG0672	)-iron permease
IAR39_RS04405	COG2837	iron assimilation
IAR39_RS04410	COG2822	iron ion transport
IAR39_RS04415	COG0604	alcohol dehydrogenase
IAR39_RS04420	COG0456	acetyltransferase
IAR39_RS04425	COG0492	ferredoxin-NADP+ reductase activity
IAR39_RS04460	COG1028	Short-chain dehydrogenase reductase Sdr
IAR39_RS04470	COG0583	DNA-binding transcription factor activity
IAR39_RS04475	COG1028	Short-chain dehydrogenase reductase Sdr
IAR39_RS04500	COG1263	PTS System
IAR39_RS04500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IAR39_RS04525	COG1301	dicarboxylic acid transport
IAR39_RS04535	COG0778	Nitroreductase
IAR39_RS04550	COG2223	nitrite transmembrane transporter activity
IAR39_RS04560	COG4585	Histidine kinase
IAR39_RS04570	COG2181	nitrate reductase activity
IAR39_RS04580	COG1140	nitrate reductase beta subunit
IAR39_RS04585	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IAR39_RS04595	COG2146	nitrite reductase [NAD(P)H] activity
IAR39_RS04600	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IAR39_RS04610	COG0747	negative chemotaxis
IAR39_RS04615	COG0454	-acetyltransferase
IAR39_RS04630	COG0803	Belongs to the bacterial solute-binding protein 9 family
IAR39_RS04645	COG2348	transferase activity, transferring amino-acyl groups
IAR39_RS04650	COG1126	abc transporter atp-binding protein
IAR39_RS04655	COG0765	amino acid transport
IAR39_RS04660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IAR39_RS04665	COG2814	Major facilitator Superfamily
IAR39_RS04675	COG0588	phosphoglycerate mutase activity
IAR39_RS04680	COG0741	lytic transglycosylase activity
IAR39_RS04685	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IAR39_RS04700	COG1929	Belongs to the glycerate kinase type-1 family
IAR39_RS04710	COG2814	Major facilitator Superfamily
IAR39_RS04725	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IAR39_RS04730	COG1113	amino acid transport
IAR39_RS04740	COG0531	amino acid
IAR39_RS04750	COG0706	membrane insertase activity
IAR39_RS04760	COG3477	response to acidic pH
IAR39_RS04770	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IAR39_RS04780	COG1380	Effector of murein hydrolase LrgA
IAR39_RS04785	COG1346	cytolysis
IAR39_RS04790	COG1174	glycine betaine transport
IAR39_RS04820	COG0531	amino acid
IAR39_RS04825	COG2272	Belongs to the type-B carboxylesterase lipase family
IAR39_RS04830	COG2814	Major facilitator Superfamily
IAR39_RS04845	COG0745	RESPONSE REGULATOR receiver
IAR39_RS04850	COG2205	protein histidine kinase activity
IAR39_RS04855	COG0390	transport system, permease component
IAR39_RS04860	COG4619	ABC transporter
IAR39_RS04875	COG0069	glutamate synthase activity
IAR39_RS04890	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IAR39_RS04895	COG4808	Protein conserved in bacteria
IAR39_RS04910	COG1028	Short-chain dehydrogenase reductase Sdr
IAR39_RS04915	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
IAR39_RS04925	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IAR39_RS04930	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IAR39_RS04960	COG0508	dehydrogenase complex catalyzes the overall conversion of
IAR39_RS04965	COG0022	dehydrogenase e1 component
IAR39_RS04970	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IAR39_RS04975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IAR39_RS04985	COG0494	nUDIX hydrolase
IAR39_RS04990	COG0438	transferase activity, transferring glycosyl groups
IAR39_RS04995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IAR39_RS05005	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IAR39_RS05010	COG2610	gluconate transmembrane transporter activity
IAR39_RS05015	COG1070	Carbohydrate kinase
IAR39_RS05020	COG1802	Transcriptional regulator
IAR39_RS05030	COG2357	RelA SpoT domain protein
IAR39_RS05035	COG4876	unkown
IAR39_RS05045	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
IAR39_RS05050	COG2271	Major facilitator Superfamily
IAR39_RS05055	COG0352	thiamine-phosphate diphosphorylase activity
IAR39_RS05070	COG2022	thiamine diphosphate biosynthetic process
IAR39_RS05075	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IAR39_RS05080	COG0586	Pfam SNARE associated Golgi protein
IAR39_RS05085	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
IAR39_RS05095	COG3949	Membrane
IAR39_RS05100	COG1012	belongs to the aldehyde dehydrogenase family
IAR39_RS05105	COG0583	DNA-binding transcription factor activity
IAR39_RS05120	COG2514	catechol 2,3-dioxygenase activity
IAR39_RS05125	COG2314	TM2 domain
IAR39_RS05145	COG1012	belongs to the aldehyde dehydrogenase family
IAR39_RS05150	COG0778	Nitroreductase
IAR39_RS05160	COG0561	phosphatase activity
IAR39_RS05165	COG3764	Sortase (surface protein transpeptidase)
IAR39_RS05180	COG1760	l-serine dehydratase
IAR39_RS05185	COG1760	l-serine dehydratase
IAR39_RS05195	COG1070	Carbohydrate kinase
IAR39_RS05215	COG2843	Capsule synthesis protein
IAR39_RS05225	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IAR39_RS05240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IAR39_RS05245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IAR39_RS05265	COG0028	Belongs to the TPP enzyme family
IAR39_RS05270	COG1346	cytolysis
IAR39_RS05275	COG1380	Effector of murein hydrolase LrgA
IAR39_RS05280	COG0583	DNA-binding transcription factor activity
IAR39_RS05290	COG3942	CHAP domain
IAR39_RS05290	COG1388	LysM domain
IAR39_RS05300	COG3425	synthase
IAR39_RS05305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IAR39_RS05335	COG1012	belongs to the aldehyde dehydrogenase family
IAR39_RS05345	COG1028	Short-chain dehydrogenase reductase Sdr
IAR39_RS05360	COG2608	mercury ion transmembrane transporter activity
IAR39_RS05370	COG0436	Aminotransferase
IAR39_RS05390	COG3942	CHAP domain
IAR39_RS05400	COG3179	chitinase
IAR39_RS05425	COG1113	amino acid transport
IAR39_RS05460	COG4221	oxidoreductase activity
IAR39_RS05470	COG0596	Alpha beta hydrolase
IAR39_RS05475	COG3001	Fructosamine kinase
IAR39_RS05480	COG0167	dihydroorotate dehydrogenase activity
IAR39_RS05490	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IAR39_RS05520	COG4640	response to antibiotic
IAR39_RS05535	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IAR39_RS05540	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IAR39_RS05550	COG3527	Alpha-acetolactate decarboxylase
IAR39_RS05555	COG0028	Belongs to the TPP enzyme family
IAR39_RS05560	COG0039	L-malate dehydrogenase activity
IAR39_RS05565	COG0583	DNA-binding transcription factor activity
IAR39_RS05575	COG0531	amino acid
IAR39_RS05600	COG0446	pyridine nucleotide-disulphide oxidoreductase
IAR39_RS05610	COG3588	fructose-bisphosphate aldolase
IAR39_RS05620	COG1695	Transcriptional regulator
IAR39_RS05630	COG2723	6-phospho-beta-galactosidase activity
IAR39_RS05635	COG1263	PTS System
IAR39_RS05635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IAR39_RS05635	COG2190	(PTS) system
IAR39_RS05640	COG2188	Transcriptional regulator
IAR39_RS05650	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IAR39_RS05655	COG0574	Belongs to the PEP-utilizing enzyme family
IAR39_RS05655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IAR39_RS05660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IAR39_RS05680	COG1473	amidohydrolase
IAR39_RS05685	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IAR39_RS05690	COG1012	belongs to the aldehyde dehydrogenase family
IAR39_RS05695	COG1510	regulation of RNA biosynthetic process
IAR39_RS05705	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IAR39_RS05710	COG0602	queuosine metabolic process
IAR39_RS05715	COG1328	CTP reductase activity
IAR39_RS05720	COG3942	CHAP domain
IAR39_RS05730	COG0529	Catalyzes the synthesis of activated sulfate
IAR39_RS05735	COG2046	Belongs to the sulfate adenylyltransferase family
IAR39_RS05740	COG0730	response to heat
IAR39_RS05755	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IAR39_RS05760	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IAR39_RS05765	COG0175	sulfate reduction
IAR39_RS05795	COG1136	(ABC) transporter
IAR39_RS05800	COG2205	protein histidine kinase activity
IAR39_RS05805	COG0745	RESPONSE REGULATOR receiver
IAR39_RS05815	COG1785	Belongs to the alkaline phosphatase family
IAR39_RS05825	COG4195	phage-related replication protein
IAR39_RS05835	COG3961	Belongs to the TPP enzyme family
IAR39_RS05850	COG2843	Capsule synthesis protein
IAR39_RS05855	COG3227	Zinc metalloprotease (Elastase)
IAR39_RS05860	COG0739	heme binding
IAR39_RS05870	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IAR39_RS05890	COG3942	CHAP domain
IAR39_RS05890	COG1705	Flagellar rod assembly protein muramidase FlgJ
IAR39_RS05900	COG1764	response to oxidative stress
IAR39_RS05910	COG2409	Drug exporters of the RND superfamily
IAR39_RS05915	COG2113	Glycine betaine
IAR39_RS05935	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IAR39_RS05940	COG0477	Major facilitator Superfamily
IAR39_RS05995	COG3639	organic phosphonate transmembrane transporter activity
IAR39_RS06010	COG0737	Belongs to the 5'-nucleotidase family
IAR39_RS06015	COG2814	Major facilitator Superfamily
IAR39_RS06035	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
IAR39_RS06040	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IAR39_RS06045	COG1288	antiporter activity
IAR39_RS06070	COG1054	Belongs to the UPF0176 family
IAR39_RS06075	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
IAR39_RS06090	COG1695	Transcriptional regulator
IAR39_RS06100	COG0471	metal ion transport
IAR39_RS06110	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
IAR39_RS06115	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
IAR39_RS06135	COG1136	(ABC) transporter
IAR39_RS06140	COG2720	vancomycin resistance protein
IAR39_RS06150	COG2205	protein histidine kinase activity
IAR39_RS06160	COG1131	(ABC) transporter
IAR39_RS06165	COG0745	RESPONSE REGULATOR receiver
IAR39_RS06205	COG1785	Belongs to the alkaline phosphatase family
IAR39_RS06255	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IAR39_RS06270	COG1288	antiporter activity
IAR39_RS06280	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
IAR39_RS06285	COG1882	Formate acetyltransferase
IAR39_RS06290	COG1876	peptidase activity
IAR39_RS06300	COG1959	2 iron, 2 sulfur cluster binding
IAR39_RS06310	COG2259	Doxx family
IAR39_RS06330	COG0789	Transcriptional regulator
IAR39_RS06335	COG1124	(ABC) transporter
IAR39_RS06345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAR39_RS06350	COG0601	transmembrane transport
IAR39_RS06355	COG0747	negative chemotaxis
IAR39_RS06370	COG0201	protein transport
IAR39_RS06380	COG1073	alpha beta
IAR39_RS06390	COG0653	protein targeting
IAR39_RS06395	COG0438	transferase activity, transferring glycosyl groups
IAR39_RS06415	COG0659	secondary active sulfate transmembrane transporter activity
IAR39_RS06420	COG1438	arginine binding
IAR39_RS06425	COG2235	arginine
IAR39_RS06445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IAR39_RS06475	COG0706	membrane insertase activity
IAR39_RS06480	COG1482	cell wall glycoprotein biosynthetic process
IAR39_RS06485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IAR39_RS06485	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IAR39_RS06485	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IAR39_RS06490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IAR39_RS06490	COG3711	transcriptional antiterminator
IAR39_RS06515	COG1518	maintenance of DNA repeat elements
IAR39_RS06525	COG0346	lactoylglutathione lyase activity
IAR39_RS06540	COG1124	(ABC) transporter
IAR39_RS06545	COG0444	Belongs to the ABC transporter superfamily
IAR39_RS06555	COG0601	transmembrane transport
IAR39_RS06585	COG1131	(ABC) transporter
IAR39_RS06605	COG2814	Major facilitator Superfamily
IAR39_RS06625	COG1869	D-ribose catabolic process
IAR39_RS06635	COG1609	Transcriptional regulator
IAR39_RS06645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IAR39_RS06680	COG2814	Major facilitator Superfamily
IAR39_RS06685	COG1114	Component of the transport system for branched-chain amino acids
IAR39_RS06690	COG0110	maltose O-acetyltransferase activity
IAR39_RS06695	COG2808	Putative FMN-binding domain
IAR39_RS06720	COG2226	methyltransferase
IAR39_RS06725	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IAR39_RS06730	COG2814	Major facilitator Superfamily
IAR39_RS06735	COG0300	oxidoreductase activity
IAR39_RS06740	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IAR39_RS06745	COG2851	Citrate transporter
IAR39_RS06770	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
IAR39_RS06800	COG1733	regulation of RNA biosynthetic process
IAR39_RS06805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IAR39_RS06815	COG3223	Belongs to the PsiE family
IAR39_RS06850	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IAR39_RS06860	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IAR39_RS06870	COG4863	YycH protein
IAR39_RS06875	COG5002	protein histidine kinase activity
IAR39_RS06880	COG0745	RESPONSE REGULATOR receiver
IAR39_RS06900	COG0305	Participates in initiation and elongation during chromosome replication
IAR39_RS06905	COG0359	binds to the 23S rRNA
IAR39_RS06910	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
IAR39_RS06920	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IAR39_RS06930	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IAR39_RS06945	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IAR39_RS06950	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IAR39_RS06955	COG0187	DNA topoisomerase II activity
IAR39_RS06960	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IAR39_RS06965	COG2501	S4 domain
IAR39_RS06970	COG0592	DNA-directed DNA polymerase activity
IAR39_RS06975	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IAR39_RS06985	COG0594	ribonuclease P activity
IAR39_RS06990	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IAR39_RS06995	COG0445	tRNA wobble uridine modification
IAR39_RS07000	COG0357	Ribosomal RNA small subunit methyltransferase G
IAR39_RS07005	COG1475	DNA binding
IAR39_RS07040	COG1136	(ABC) transporter
IAR39_RS07045	COG0577	efflux transmembrane transporter activity
IAR39_RS07060	COG2348	transferase activity, transferring amino-acyl groups
IAR39_RS07140	COG0577	efflux transmembrane transporter activity
IAR39_RS07145	COG1136	(ABC) transporter
IAR39_RS07165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IAR39_RS07185	COG1131	(ABC) transporter
IAR39_RS07195	COG1476	TRANSCRIPTIONal
IAR39_RS07240	COG2207	Transcriptional regulator
IAR39_RS07245	COG0800	Aldolase
IAR39_RS07250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IAR39_RS07255	COG2211	Major facilitator Superfamily
IAR39_RS07260	COG1904	glucuronate isomerase
IAR39_RS07265	COG1312	Catalyzes the dehydration of D-mannonate
IAR39_RS07270	COG1028	Short-chain dehydrogenase reductase Sdr
IAR39_RS07275	COG3250	beta-galactosidase activity
IAR39_RS07285	COG3942	CHAP domain
IAR39_RS07300	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IAR39_RS07305	COG0646	methionine synthase
IAR39_RS07305	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IAR39_RS07310	COG0626	cystathionine gamma-synthase activity
IAR39_RS07315	COG0626	cystathionine gamma-synthase activity
IAR39_RS07320	COG1475	DNA binding
IAR39_RS07325	COG0668	transmembrane transport
IAR39_RS07330	COG4481	Protein conserved in bacteria
IAR39_RS07335	COG0012	GTP binding
IAR39_RS07350	COG0360	Binds together with S18 to 16S ribosomal RNA
IAR39_RS07360	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IAR39_RS07365	COG0582	viral genome integration into host DNA
IAR39_RS07450	COG5484	DNA packaging
IAR39_RS07450	COG3728	DNA packaging
IAR39_RS07470	COG1280	lysine exporter protein (LysE YggA)
IAR39_RS07495	COG3634	alkyl hydroperoxide reductase activity
IAR39_RS07500	COG0450	alkyl hydroperoxide reductase
IAR39_RS07515	COG3279	Response regulator of the LytR AlgR family
IAR39_RS07520	COG0778	Nitroreductase
IAR39_RS07525	COG1823	symporter activity
IAR39_RS07535	COG5183	chlorophyll binding
IAR39_RS07550	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IAR39_RS07555	COG2233	PERMEase
IAR39_RS07560	COG0517	IMP dehydrogenase activity
IAR39_RS07560	COG0516	GMP reductase activity
IAR39_RS07565	COG0519	Catalyzes the synthesis of GMP from XMP
IAR39_RS07565	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IAR39_RS07575	COG0523	cobalamin synthesis protein
IAR39_RS07590	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IAR39_RS07595	COG3002	Belongs to the UPF0753 family
IAR39_RS07600	COG5609	conserved protein (DUF2294)
IAR39_RS07615	COG0671	phosphoesterase, PA-phosphatase related
IAR39_RS07620	COG1647	Serine aminopeptidase, S33
IAR39_RS07630	COG0733	neurotransmitter:sodium symporter activity
IAR39_RS07635	COG1279	arginine transmembrane transporter activity
IAR39_RS07650	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IAR39_RS07655	COG0626	cystathionine gamma-synthase activity
IAR39_RS07660	COG1846	Transcriptional regulator
IAR39_RS07690	COG3759	membrane
IAR39_RS07695	COG1278	Cold shock
IAR39_RS07710	COG0438	transferase activity, transferring glycosyl groups
IAR39_RS07720	COG0494	nUDIX hydrolase
IAR39_RS07725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IAR39_RS07745	COG0069	glutamate synthase activity
IAR39_RS07745	COG0070	glutamate synthase
IAR39_RS07745	COG0067	glutamate synthase
IAR39_RS07750	COG0493	'glutamate synthase
IAR39_RS07760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IAR39_RS07760	COG1263	PTS System
IAR39_RS07765	COG0366	Alpha amylase catalytic
IAR39_RS07770	COG2188	Transcriptional regulator
IAR39_RS07785	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IAR39_RS07795	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IAR39_RS07815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IAR39_RS07820	COG1982	Orn Lys Arg decarboxylase major
IAR39_RS07830	COG3870	Protein conserved in bacteria
IAR39_RS07835	COG0470	DNA polymerase III
IAR39_RS07840	COG1774	PSP1 C-terminal conserved region
IAR39_RS07845	COG4467	Involved in initiation control of chromosome replication
IAR39_RS07850	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IAR39_RS07855	COG2827	Endonuclease containing a URI domain
IAR39_RS07860	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IAR39_RS07865	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IAR39_RS07865	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IAR39_RS07870	COG0084	hydrolase, TatD family'
IAR39_RS07875	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
IAR39_RS07880	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IAR39_RS07885	COG4466	Protein conserved in bacteria
IAR39_RS07890	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IAR39_RS07895	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IAR39_RS07900	COG0251	oxidation-reduction process
IAR39_RS07905	COG2088	sporulation resulting in formation of a cellular spore
IAR39_RS07910	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IAR39_RS07915	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IAR39_RS07920	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IAR39_RS07925	COG0193	aminoacyl-tRNA hydrolase activity
IAR39_RS07930	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IAR39_RS07935	COG2244	polysaccharide biosynthetic process
IAR39_RS07940	COG3956	TIGRFAM MazG family protein
IAR39_RS07945	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IAR39_RS07955	COG1098	S1 RNA binding domain
IAR39_RS07970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IAR39_RS07990	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IAR39_RS07995	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IAR39_RS08000	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IAR39_RS08085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IAR39_RS08090	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
IAR39_RS08095	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
IAR39_RS08100	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IAR39_RS08110	COG3880	PFAM UvrB UvrC protein
IAR39_RS08115	COG3869	Catalyzes the specific phosphorylation of arginine residues in
IAR39_RS08120	COG0542	response to heat
IAR39_RS08125	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IAR39_RS08130	COG4956	integral membrane protein (PIN domain superfamily)
IAR39_RS08135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IAR39_RS08145	COG0215	cysteine-tRNA ligase activity
IAR39_RS08150	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
IAR39_RS08160	COG3688	RNA-binding protein containing a PIN domain
IAR39_RS08170	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IAR39_RS08180	COG0250	Participates in transcription elongation, termination and antitermination
IAR39_RS08185	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IAR39_RS08190	COG0081	regulation of translation
IAR39_RS08195	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IAR39_RS08200	COG0222	ribosome binding
IAR39_RS08205	COG2813	Specifically methylates the guanine in position
IAR39_RS08210	COG0085	RNA polymerase activity
IAR39_RS08215	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IAR39_RS08225	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IAR39_RS08230	COG0049	tRNA binding
IAR39_RS08235	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IAR39_RS08240	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IAR39_RS08245	COG1473	amidohydrolase
IAR39_RS08270	COG1349	DNA-binding transcription factor activity
IAR39_RS08280	COG1063	alcohol dehydrogenase
IAR39_RS08295	COG0737	Belongs to the 5'-nucleotidase family
IAR39_RS08305	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IAR39_RS08310	COG0546	phosphoglycolate phosphatase activity
IAR39_RS08315	COG1428	Deoxynucleoside kinase
IAR39_RS08320	COG1428	Deoxynucleoside kinase
IAR39_RS08330	COG0561	phosphatase activity
IAR39_RS08335	COG0431	NADPH-dependent FMN reductase
IAR39_RS08365	COG2271	Major facilitator Superfamily
IAR39_RS08370	COG1469	GTP cyclohydrolase I activity
IAR39_RS08375	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IAR39_RS08385	COG0363	glucosamine-6-phosphate deaminase activity
IAR39_RS08390	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
IAR39_RS08405	COG0477	Major facilitator Superfamily
IAR39_RS08430	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
IAR39_RS08445	COG2363	Small membrane protein
IAR39_RS08465	COG3253	May function as heme-dependent peroxidase
IAR39_RS08470	COG0280	phosphate acetyltransferase
IAR39_RS08475	COG0095	Lipoate-protein ligase
IAR39_RS08480	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IAR39_RS08495	COG4844	belongs to the
IAR39_RS08500	COG0667	Aldo Keto reductase
IAR39_RS08505	COG0655	NAD(P)H dehydrogenase (quinone) activity
IAR39_RS08515	COG1078	dGTPase activity
IAR39_RS08535	COG0018	arginyl-trna synthetase
IAR39_RS08540	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IAR39_RS08555	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IAR39_RS08560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAR39_RS08565	COG0546	phosphoglycolate phosphatase activity
IAR39_RS08585	COG2267	carboxylic ester hydrolase activity
IAR39_RS08620	COG2111	Na H antiporter
IAR39_RS08620	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IAR39_RS08625	COG2111	Na H antiporter
IAR39_RS08630	COG1006	Multisubunit Na H antiporter MnhC subunit
IAR39_RS08635	COG0651	ATP synthesis coupled electron transport
IAR39_RS08640	COG1863	multisubunit Na H antiporter MnhE subunit
IAR39_RS08650	COG1320	monovalent cation:proton antiporter activity
IAR39_RS08660	COG0803	Belongs to the bacterial solute-binding protein 9 family
IAR39_RS08665	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IAR39_RS08670	COG1121	(ABC) transporter
IAR39_RS08685	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
IAR39_RS08690	COG1134	teichoic acid transport
IAR39_RS08695	COG1682	transport, permease protein
IAR39_RS08700	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IAR39_RS08710	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IAR39_RS08715	COG1686	Belongs to the peptidase S11 family
IAR39_RS08720	COG1132	(ABC) transporter
IAR39_RS08725	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IAR39_RS08730	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IAR39_RS08735	COG1120	ATPase activity
IAR39_RS08740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAR39_RS08745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAR39_RS08750	COG2376	Dihydroxyacetone kinase
IAR39_RS08760	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
IAR39_RS08770	COG3949	Membrane
IAR39_RS08775	COG0657	acetylesterase activity
IAR39_RS08785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IAR39_RS08795	COG2205	protein histidine kinase activity
IAR39_RS08800	COG1136	(ABC) transporter
IAR39_RS08805	COG0577	efflux transmembrane transporter activity
IAR39_RS08815	COG1392	Phosphate transport regulator
IAR39_RS08820	COG0306	phosphate transporter
IAR39_RS08830	COG1388	LysM domain
IAR39_RS08830	COG3942	CHAP domain
IAR39_RS08840	COG2207	Transcriptional regulator
IAR39_RS08840	COG0662	Cupin 2, conserved barrel domain protein
IAR39_RS08850	COG0217	transcriptional regulatory protein
IAR39_RS08865	COG0583	DNA-binding transcription factor activity
IAR39_RS08870	COG2814	Major facilitator Superfamily
IAR39_RS08875	COG2839	Protein conserved in bacteria
IAR39_RS08900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IAR39_RS08910	COG1959	2 iron, 2 sulfur cluster binding
IAR39_RS08925	COG1611	Belongs to the LOG family
IAR39_RS08930	COG1671	Belongs to the UPF0178 family
IAR39_RS08940	COG1968	undecaprenyl-diphosphatase activity
IAR39_RS08945	COG4988	ABC transporter
IAR39_RS08950	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IAR39_RS08960	COG0523	cobalamin synthesis protein
IAR39_RS08965	COG4989	oxidoreductase activity
IAR39_RS08975	COG0039	L-malate dehydrogenase activity
IAR39_RS08980	COG0471	metal ion transport
IAR39_RS08985	COG0415	Belongs to the DNA photolyase family
IAR39_RS09010	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IAR39_RS09015	COG1349	DNA-binding transcription factor activity
IAR39_RS09020	COG1105	Belongs to the carbohydrate kinase PfkB family
IAR39_RS09025	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IAR39_RS09025	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IAR39_RS09025	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IAR39_RS09030	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IAR39_RS09035	COG1253	flavin adenine dinucleotide binding
IAR39_RS09040	COG0656	L-ascorbic acid biosynthetic process
IAR39_RS09045	COG0463	Glycosyl transferase, family 2
IAR39_RS09055	COG0602	queuosine metabolic process
IAR39_RS09060	COG0720	synthase
IAR39_RS09065	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IAR39_RS09070	COG0512	Glutamine amidotransferase of anthranilate synthase
IAR39_RS09070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IAR39_RS09100	COG1368	sulfuric ester hydrolase activity
IAR39_RS09110	COG0488	(ABC) transporter
IAR39_RS09115	COG0514	ATP-dependent DNA helicase (RecQ)
IAR39_RS09125	COG1174	glycine betaine transport
IAR39_RS09130	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IAR39_RS09140	COG1597	lipid kinase activity
IAR39_RS09145	COG3104	oligopeptide transport
IAR39_RS09160	COG1780	Probably involved in ribonucleotide reductase function
IAR39_RS09165	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IAR39_RS09170	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IAR39_RS09175	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IAR39_RS09180	COG4605	iron ion homeostasis
IAR39_RS09185	COG4604	ABC transporter, ATP-binding protein
IAR39_RS09200	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IAR39_RS09220	COG1929	Belongs to the glycerate kinase type-1 family
IAR39_RS09225	COG2195	Cleaves the N-terminal amino acid of tripeptides
IAR39_RS09245	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IAR39_RS09250	COG1739	Uncharacterized protein family UPF0029
IAR39_RS09260	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
IAR39_RS09265	COG1040	competence protein
IAR39_RS09270	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IAR39_RS09275	COG0653	protein targeting
IAR39_RS09285	COG3942	CHAP domain
IAR39_RS09285	COG1388	LysM domain
IAR39_RS09300	COG0556	nucleotide-excision repair
IAR39_RS09305	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IAR39_RS09315	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IAR39_RS09330	COG0492	ferredoxin-NADP+ reductase activity
IAR39_RS09335	COG1660	Displays ATPase and GTPase activities
IAR39_RS09340	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IAR39_RS09345	COG1481	regulation of sporulation
IAR39_RS09355	COG0740	serine-type endopeptidase activity
IAR39_RS09380	COG0126	phosphoglycerate kinase activity
IAR39_RS09385	COG0149	triose-phosphate isomerase activity
IAR39_RS09390	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IAR39_RS09395	COG0148	phosphopyruvate hydratase activity
IAR39_RS09405	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IAR39_RS09410	COG1647	Serine aminopeptidase, S33
IAR39_RS09415	COG0557	exoribonuclease II activity
IAR39_RS09480	COG1309	transcriptional regulator
IAR39_RS09485	COG0656	L-ascorbic acid biosynthetic process
IAR39_RS09510	COG1278	Cold shock
IAR39_RS09535	COG4195	phage-related replication protein
IAR39_RS09570	COG0406	alpha-ribazole phosphatase activity
IAR39_RS09580	COG1764	response to oxidative stress
IAR39_RS09585	COG0710	3-dehydroquinate dehydratase activity
IAR39_RS09595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IAR39_RS09600	COG1393	Belongs to the ArsC family
IAR39_RS09605	COG0509	glycine decarboxylation via glycine cleavage system
IAR39_RS09610	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
IAR39_RS09620	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IAR39_RS09625	COG2011	ABC-type metal ion transport system permease component
IAR39_RS09630	COG1464	Belongs to the NlpA lipoprotein family
IAR39_RS09635	COG3237	CsbD-like
IAR39_RS09645	COG0396	ATPase activity
IAR39_RS09650	COG0719	Fe-S assembly protein
IAR39_RS09655	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IAR39_RS09660	COG0822	iron-sulfur transferase activity
IAR39_RS09665	COG0719	Fe-S assembly protein
IAR39_RS09670	COG1253	flavin adenine dinucleotide binding
IAR39_RS09675	COG2070	2-Nitropropane dioxygenase
IAR39_RS09680	COG1801	Protein of unknown function DUF72
IAR39_RS09685	COG0730	response to heat
IAR39_RS09690	COG0737	Belongs to the 5'-nucleotidase family
IAR39_RS09695	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IAR39_RS09700	COG4470	Protein conserved in bacteria
IAR39_RS09710	COG2445	Protein of unknown function DUF86
IAR39_RS09730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IAR39_RS09735	COG1696	Membrane protein involved in D-alanine export
IAR39_RS09745	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
IAR39_RS09755	COG0583	DNA-binding transcription factor activity
IAR39_RS09760	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IAR39_RS09765	COG4837	Protein of unknown function (DUF1462)
IAR39_RS09770	COG1252	NADH dehydrogenase
IAR39_RS09775	COG4844	belongs to the
IAR39_RS09780	COG0316	Belongs to the HesB IscA family
IAR39_RS09790	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IAR39_RS09795	COG2056	Na+-H+ antiporter family
IAR39_RS09800	COG2050	protein possibly involved in aromatic compounds catabolism
IAR39_RS09820	COG2212	antiporter activity
IAR39_RS09830	COG0651	ATP synthesis coupled electron transport
IAR39_RS09835	COG1006	Multisubunit Na H antiporter MnhC subunit
IAR39_RS09840	COG2111	Na H antiporter
IAR39_RS09845	COG2111	Na H antiporter
IAR39_RS09845	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IAR39_RS09860	COG1098	S1 RNA binding domain
IAR39_RS09865	COG1902	pentaerythritol trinitrate reductase activity
IAR39_RS09885	COG0584	glycerophosphoryl diester phosphodiesterase
IAR39_RS09890	COG0584	glycerophosphoryl diester phosphodiesterase
IAR39_RS09895	COG0165	Argininosuccinate lyase
IAR39_RS09900	COG0137	argininosuccinate synthase activity
IAR39_RS09910	COG0398	Pfam SNARE associated Golgi protein
IAR39_RS09930	COG1074	ATP-dependent DNA helicase activity
IAR39_RS09945	COG0446	pyridine nucleotide-disulphide oxidoreductase
IAR39_RS09950	COG0561	phosphatase activity
IAR39_RS09965	COG0542	response to heat
IAR39_RS09975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IAR39_RS09990	COG0601	transmembrane transport
IAR39_RS09995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IAR39_RS10000	COG0444	Belongs to the ABC transporter superfamily
IAR39_RS10005	COG4608	Belongs to the ABC transporter superfamily
IAR39_RS10010	COG4166	transmembrane transport
IAR39_RS10015	COG0180	Tryptophanyl-tRNA synthetase
IAR39_RS10020	COG1393	Belongs to the ArsC family
IAR39_RS10025	COG4862	establishment of competence for transformation
IAR39_RS10035	COG1164	Oligoendopeptidase f
IAR39_RS10040	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IAR39_RS10045	COG2346	COG2346, Truncated hemoglobins
IAR39_RS10060	COG2357	RelA SpoT domain protein
IAR39_RS10065	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IAR39_RS10070	COG0564	pseudouridine synthase activity
IAR39_RS10075	COG2239	Acts as a magnesium transporter
IAR39_RS10080	COG0475	glutathione-regulated potassium exporter activity
IAR39_RS10080	COG0569	domain protein
IAR39_RS10090	COG0628	permease
IAR39_RS10095	COG1115	amino acid carrier protein
IAR39_RS10100	COG2382	esterase
IAR39_RS10105	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IAR39_RS10110	COG2814	Major facilitator Superfamily
IAR39_RS10115	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IAR39_RS10120	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IAR39_RS10130	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IAR39_RS10135	COG0861	Integral membrane protein TerC family
IAR39_RS10140	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IAR39_RS10145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IAR39_RS10160	COG4873	Protein conserved in bacteria
IAR39_RS10195	COG2314	TM2 domain
IAR39_RS10200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IAR39_RS10205	COG1575	Belongs to the MenA family. Type 1 subfamily
IAR39_RS10210	COG1169	isochorismate synthase
IAR39_RS10215	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IAR39_RS10225	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
IAR39_RS10230	COG0436	Aminotransferase
IAR39_RS10235	COG3594	Acyltransferase
IAR39_RS10260	COG1316	TRANSCRIPTIONal
IAR39_RS10275	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IAR39_RS10290	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IAR39_RS10300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IAR39_RS10300	COG1017	nitric oxide dioxygenase activity
IAR39_RS10305	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IAR39_RS10310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IAR39_RS10320	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IAR39_RS10325	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IAR39_RS10330	COG0047	phosphoribosylformylglycinamidine synthase activity
IAR39_RS10345	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IAR39_RS10355	COG0138	bifunctional purine biosynthesis protein purh
IAR39_RS10360	COG0151	Belongs to the GarS family
IAR39_RS10365	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IAR39_RS10370	COG4172	Belongs to the ABC transporter superfamily
IAR39_RS10385	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IAR39_RS10395	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IAR39_RS10400	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IAR39_RS10410	COG1271	oxidase subunit
IAR39_RS10415	COG1294	oxidase, subunit
IAR39_RS10420	COG0569	domain protein
IAR39_RS10425	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IAR39_RS10430	COG5503	Protein of unknown function (DUF1447)
IAR39_RS10435	COG0242	peptide deformylase activity
IAR39_RS10455	COG0508	dehydrogenase complex catalyzes the overall conversion of
IAR39_RS10465	COG4476	Belongs to the UPF0223 family
IAR39_RS10480	COG1176	ABC-type spermidine putrescine transport system, permease component I
IAR39_RS10485	COG1177	transmembrane transport
IAR39_RS10510	COG4493	Belongs to the UPF0637 family
IAR39_RS10515	COG0483	inositol monophosphate 1-phosphatase activity
IAR39_RS10525	COG1217	gtp-binding protein TYPA
IAR39_RS10530	COG4896	Protein conserved in bacteria
IAR39_RS10535	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IAR39_RS10540	COG4838	Belongs to the UPF0358 family
IAR39_RS10545	COG0772	Belongs to the SEDS family
IAR39_RS10555	COG1612	heme a metabolic process
IAR39_RS10560	COG0109	protoheme IX farnesyltransferase activity
IAR39_RS10575	COG3679	Belongs to the UPF0342 family
IAR39_RS10580	COG0584	glycerophosphoryl diester phosphodiesterase
IAR39_RS10595	COG0742	ribosomal rna small subunit methyltransferase
IAR39_RS10600	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IAR39_RS10615	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IAR39_RS10620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IAR39_RS10625	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IAR39_RS10630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IAR39_RS10630	COG0072	phenylalanine-tRNA ligase activity
IAR39_RS10635	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IAR39_RS10640	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
IAR39_RS10650	COG1796	DNA polymerase
IAR39_RS10650	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IAR39_RS10655	COG1193	negative regulation of DNA recombination
IAR39_RS10660	COG3118	belongs to the thioredoxin family
IAR39_RS10665	COG0322	excinuclease ABC activity
IAR39_RS10670	COG2009	succinate dehydrogenase
IAR39_RS10675	COG1053	succinate dehydrogenase
IAR39_RS10680	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IAR39_RS10685	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IAR39_RS10690	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IAR39_RS10700	COG0582	viral genome integration into host DNA
IAR39_RS10795	COG1484	DNA-dependent DNA replication
IAR39_RS11020	COG5632	N-Acetylmuramoyl-L-alanine amidase
IAR39_RS11020	COG1388	LysM domain
IAR39_RS11070	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
IAR39_RS11080	COG0275	rRNA processing
IAR39_RS11085	COG4839	cell division protein FtsL
IAR39_RS11090	COG0768	penicillin binding
IAR39_RS11095	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IAR39_RS11105	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IAR39_RS11110	COG0849	cell division
IAR39_RS11115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IAR39_RS11120	COG1496	oxidoreductase activity
IAR39_RS11125	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IAR39_RS11130	COG1799	cell septum assembly
IAR39_RS11135	COG0762	integral membrane protein
IAR39_RS11140	COG3599	regulation of cell shape
IAR39_RS11165	COG3942	CHAP domain
IAR39_RS11165	COG1388	LysM domain
IAR39_RS11175	COG0564	pseudouridine synthase activity
IAR39_RS11185	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IAR39_RS11190	COG2233	PERMEase
IAR39_RS11195	COG0540	Belongs to the ATCase OTCase family
IAR39_RS11200	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IAR39_RS11205	COG0505	Belongs to the CarA family
IAR39_RS11210	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IAR39_RS11215	COG0284	orotidine-5'-phosphate decarboxylase activity
IAR39_RS11240	COG0194	GDP metabolic process
IAR39_RS11245	COG1758	RNA polymerase activity
IAR39_RS11250	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IAR39_RS11255	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IAR39_RS11265	COG0242	peptide deformylase activity
IAR39_RS11270	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IAR39_RS11275	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IAR39_RS11275	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IAR39_RS11280	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IAR39_RS11285	COG0631	protein serine/threonine phosphatase activity
IAR39_RS11300	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IAR39_RS11310	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IAR39_RS11315	COG1302	Protein conserved in bacteria
IAR39_RS11320	COG1461	Dihydroxyacetone kinase
IAR39_RS11325	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IAR39_RS11330	COG1349	DNA-binding transcription factor activity
IAR39_RS11335	COG0416	fatty acid biosynthetic process
IAR39_RS11350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IAR39_RS11355	COG0571	ribonuclease III activity
IAR39_RS11365	COG0552	protein localization to endoplasmic reticulum
IAR39_RS11370	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
IAR39_RS11375	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IAR39_RS11380	COG0228	four-way junction DNA binding
IAR39_RS11385	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IAR39_RS11390	COG0336	Belongs to the RNA methyltransferase TrmD family
IAR39_RS11405	COG4485	Bacterial membrane protein, YfhO
IAR39_RS11415	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IAR39_RS11420	COG0045	succinate-CoA ligase (ADP-forming) activity
IAR39_RS11425	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IAR39_RS11430	COG0758	DNA mediated transformation
IAR39_RS11435	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IAR39_RS11440	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
IAR39_RS11445	COG4974	Belongs to the 'phage' integrase family
IAR39_RS11450	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IAR39_RS11465	COG0052	Belongs to the universal ribosomal protein uS2 family
IAR39_RS11470	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IAR39_RS11475	COG0528	UMP kinase activity
IAR39_RS11480	COG0233	cytoplasmic translational termination
IAR39_RS11485	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IAR39_RS11490	COG4589	Belongs to the CDS family
IAR39_RS11500	COG0442	prolyl-tRNA aminoacylation
IAR39_RS11505	COG2176	DNA-directed DNA polymerase activity
IAR39_RS11510	COG0779	Required for maturation of 30S ribosomal subunits
IAR39_RS11515	COG0195	Participates in both transcription termination and antitermination
IAR39_RS11520	COG2740	Nucleic-acid-binding protein implicated in transcription termination
IAR39_RS11525	COG1358	cellular component organization or biogenesis
IAR39_RS11530	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IAR39_RS11535	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IAR39_RS11540	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IAR39_RS11545	COG0196	riboflavin kinase activity
IAR39_RS11550	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IAR39_RS11555	COG1185	polyribonucleotide nucleotidyltransferase activity
IAR39_RS11560	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IAR39_RS11570	COG2188	Transcriptional regulator
IAR39_RS11575	COG0612	Peptidase, M16
IAR39_RS11580	COG0612	Peptidase, M16
IAR39_RS11585	COG1028	Short-chain dehydrogenase reductase Sdr
IAR39_RS11595	COG1426	Protein conserved in bacteria
IAR39_RS11605	COG1058	Belongs to the CinA family
IAR39_RS11605	COG1546	Belongs to the CinA family
IAR39_RS11610	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IAR39_RS11615	COG1418	mRNA catabolic process
IAR39_RS11625	COG1692	metallophosphoesterase
IAR39_RS11630	COG0674	pyruvate-flavodoxin oxidoreductase activity
IAR39_RS11630	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IAR39_RS11635	COG1013	pyruvate-flavodoxin oxidoreductase activity
IAR39_RS11640	COG4195	phage-related replication protein
IAR39_RS11650	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IAR39_RS11655	COG4550	Control of competence regulator ComK, YlbF/YmcA
IAR39_RS11670	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IAR39_RS11675	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
IAR39_RS11680	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IAR39_RS11690	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IAR39_RS11700	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IAR39_RS11705	COG1923	regulation of RNA biosynthetic process
IAR39_RS11710	COG0386	Belongs to the glutathione peroxidase family
IAR39_RS11715	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IAR39_RS11720	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
IAR39_RS11725	COG0789	Transcriptional regulator
IAR39_RS11780	COG1525	nuclease
IAR39_RS11795	COG0527	aspartate kinase activity
IAR39_RS11800	COG0460	homoserine dehydrogenase
IAR39_RS11805	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IAR39_RS11810	COG0083	homoserine kinase activity
IAR39_RS11825	COG0833	amino acid
IAR39_RS11840	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IAR39_RS11865	COG4224	UPF0291 protein
IAR39_RS11875	COG3763	UPF0154 protein
IAR39_RS11880	COG4846	Membrane protein involved in cytochrome C biogenesis
IAR39_RS11895	COG1970	mechanosensitive ion channel activity
IAR39_RS11900	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IAR39_RS11910	COG0824	Thioesterase
IAR39_RS11925	COG0187	DNA topoisomerase II activity
IAR39_RS11935	COG1115	amino acid carrier protein
IAR39_RS11940	COG3711	transcriptional antiterminator
IAR39_RS11945	COG0628	permease
IAR39_RS11950	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IAR39_RS11950	COG0392	lysyltransferase activity
IAR39_RS11965	COG1942	4-Oxalocrotonate Tautomerase
IAR39_RS11970	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IAR39_RS11975	COG0287	Prephenate dehydrogenase
IAR39_RS11980	COG1363	Peptidase, m42
IAR39_RS11985	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IAR39_RS11990	COG0512	Glutamine amidotransferase of anthranilate synthase
IAR39_RS12000	COG0134	indole-3-glycerol-phosphate synthase activity
IAR39_RS12020	COG2348	transferase activity, transferring amino-acyl groups
IAR39_RS12025	COG2348	transferase activity, transferring amino-acyl groups
IAR39_RS12030	COG0561	phosphatase activity
IAR39_RS12035	COG4607	ABC-type enterochelin transport system periplasmic component
IAR39_RS12075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IAR39_RS12080	COG0581	inorganic phosphate transmembrane transporter activity
IAR39_RS12085	COG0573	inorganic phosphate transmembrane transporter activity
IAR39_RS12090	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IAR39_RS12095	COG2996	Protein conserved in bacteria
IAR39_RS12100	COG0488	(ABC) transporter
IAR39_RS12105	COG0527	aspartate kinase activity
IAR39_RS12110	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IAR39_RS12115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IAR39_RS12120	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IAR39_RS12130	COG1473	amidohydrolase
IAR39_RS12145	COG1278	Cold shock
IAR39_RS12155	COG1254	Belongs to the acylphosphatase family
IAR39_RS12165	COG3853	Toxic anion resistance protein (TelA)
IAR39_RS12170	COG1114	Component of the transport system for branched-chain amino acids
IAR39_RS12175	COG4548	von Willebrand factor, type A
IAR39_RS12180	COG0714	Associated with various cellular activities
IAR39_RS12205	COG1131	(ABC) transporter
IAR39_RS12210	COG0508	dehydrogenase complex catalyzes the overall conversion of
IAR39_RS12215	COG0567	Dehydrogenase, E1 component
IAR39_RS12220	COG5002	protein histidine kinase activity
IAR39_RS12225	COG0745	RESPONSE REGULATOR receiver
IAR39_RS12230	COG0671	phosphoesterase, PA-phosphatase related
IAR39_RS12235	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IAR39_RS12245	COG0793	Belongs to the peptidase S41A family
IAR39_RS12255	COG2190	(PTS) system
IAR39_RS12260	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IAR39_RS12290	COG1413	lyase activity
IAR39_RS12295	COG1413	lyase activity
IAR39_RS12305	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IAR39_RS12320	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IAR39_RS12330	COG3682	Transcriptional regulator
IAR39_RS12350	COG1131	(ABC) transporter
IAR39_RS12365	COG1192	Involved in chromosome partitioning
IAR39_RS12425	COG2217	Heavy metal translocating P-type atpase
IAR39_RS12430	COG1937	Protein conserved in bacteria
IAR39_RS12645	COG1132	(ABC) transporter