locus-tag	class	description
DMSX03_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DMSX03_RS00010	COG0592	DNA-directed DNA polymerase activity
DMSX03_RS00015	COG2501	S4 domain
DMSX03_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DMSX03_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DMSX03_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DMSX03_RS00040	COG2986	histidine ammonia-lyase
DMSX03_RS00045	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DMSX03_RS00050	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DMSX03_RS00060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DMSX03_RS00070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
DMSX03_RS00075	COG0359	binds to the 23S rRNA
DMSX03_RS00080	COG0305	Participates in initiation and elongation during chromosome replication
DMSX03_RS00085	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DMSX03_RS00090	COG1819	glycosyl
DMSX03_RS00105	COG0745	RESPONSE REGULATOR receiver
DMSX03_RS00110	COG5002	protein histidine kinase activity
DMSX03_RS00125	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DMSX03_RS00130	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DMSX03_RS00200	COG1401	restriction endodeoxyribonuclease activity
DMSX03_RS00210	COG1959	2 iron, 2 sulfur cluster binding
DMSX03_RS00215	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DMSX03_RS00220	COG2910	NAD(P)H-binding
DMSX03_RS00225	COG0583	DNA-binding transcription factor activity
DMSX03_RS00235	COG3181	Tripartite tricarboxylate transporter family receptor
DMSX03_RS00255	COG1609	Transcriptional regulator
DMSX03_RS00270	COG1942	4-Oxalocrotonate Tautomerase
DMSX03_RS00280	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
DMSX03_RS00285	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DMSX03_RS00295	COG1136	(ABC) transporter
DMSX03_RS00300	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DMSX03_RS00315	COG0702	epimerase
DMSX03_RS00320	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
DMSX03_RS00355	COG0415	Belongs to the DNA photolyase family
DMSX03_RS00370	COG3711	transcriptional antiterminator
DMSX03_RS00375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DMSX03_RS00375	COG1263	PTS System
DMSX03_RS00380	COG2723	6-phospho-beta-galactosidase activity
DMSX03_RS00395	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
DMSX03_RS00400	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DMSX03_RS00425	COG0601	transmembrane transport
DMSX03_RS00435	COG0444	Belongs to the ABC transporter superfamily
DMSX03_RS00440	COG1124	(ABC) transporter
DMSX03_RS00470	COG0583	DNA-binding transcription factor activity
DMSX03_RS00475	COG2207	Transcriptional regulator
DMSX03_RS00480	COG2211	Major facilitator Superfamily
DMSX03_RS00485	COG3250	beta-galactosidase activity
DMSX03_RS00490	COG2814	Major facilitator Superfamily
DMSX03_RS00515	COG2814	Major facilitator Superfamily
DMSX03_RS00520	COG0463	Glycosyl transferase, family 2
DMSX03_RS00540	COG1695	Transcriptional regulator
DMSX03_RS00545	COG1028	Short-chain dehydrogenase reductase Sdr
DMSX03_RS00550	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DMSX03_RS00555	COG1063	alcohol dehydrogenase
DMSX03_RS00565	COG1063	alcohol dehydrogenase
DMSX03_RS00570	COG3775	system Galactitol-specific IIC component
DMSX03_RS00575	COG3414	Phosphotransferase system galactitol-specific IIB component
DMSX03_RS00620	COG3192	ethanolamine utilization protein
DMSX03_RS00625	COG1028	Short-chain dehydrogenase reductase Sdr
DMSX03_RS00635	COG1012	belongs to the aldehyde dehydrogenase family
DMSX03_RS00640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DMSX03_RS00650	COG2318	DinB family
DMSX03_RS00670	COG5002	protein histidine kinase activity
DMSX03_RS00675	COG1388	LysM domain
DMSX03_RS00680	COG1388	LysM domain
DMSX03_RS00685	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DMSX03_RS00690	COG1054	Belongs to the UPF0176 family
DMSX03_RS00695	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DMSX03_RS00695	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DMSX03_RS00700	COG1609	Transcriptional regulator
DMSX03_RS00710	COG0235	Class ii aldolase
DMSX03_RS00715	COG2160	L-arabinose isomerase activity
DMSX03_RS00730	COG1131	(ABC) transporter
DMSX03_RS00740	COG1695	Transcriptional regulator
DMSX03_RS00745	COG3479	Phenolic acid decarboxylase
DMSX03_RS00750	COG0477	Major facilitator Superfamily
DMSX03_RS00750	COG2814	Major facilitator Superfamily
DMSX03_RS00755	COG1070	Carbohydrate kinase
DMSX03_RS00760	COG2115	Belongs to the xylose isomerase family
DMSX03_RS00765	COG1940	carbohydrate kinase activity
DMSX03_RS00765	COG1846	Transcriptional regulator
DMSX03_RS00770	COG1511	domain protein
DMSX03_RS00785	COG1917	Cupin 2, conserved barrel domain protein
DMSX03_RS00785	COG2207	Transcriptional regulator
DMSX03_RS00805	COG1070	Carbohydrate kinase
DMSX03_RS00810	COG0352	thiamine-phosphate diphosphorylase activity
DMSX03_RS00815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DMSX03_RS00825	COG2022	thiamine diphosphate biosynthetic process
DMSX03_RS00830	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DMSX03_RS00840	COG0602	queuosine metabolic process
DMSX03_RS00845	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DMSX03_RS00855	COG0431	NADPH-dependent FMN reductase
DMSX03_RS00865	COG0346	lactoylglutathione lyase activity
DMSX03_RS00870	COG2188	Transcriptional regulator
DMSX03_RS00875	COG2084	Dehydrogenase
DMSX03_RS00910	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DMSX03_RS00915	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DMSX03_RS00920	COG0579	oxidoreductase
DMSX03_RS00940	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DMSX03_RS00960	COG2814	Major facilitator Superfamily
DMSX03_RS00970	COG0584	glycerophosphoryl diester phosphodiesterase
DMSX03_RS00980	COG0668	transmembrane transport
DMSX03_RS00985	COG1846	Transcriptional regulator
DMSX03_RS00990	COG3961	Belongs to the TPP enzyme family
DMSX03_RS01000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DMSX03_RS01040	COG0673	inositol 2-dehydrogenase activity
DMSX03_RS01045	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
DMSX03_RS01050	COG1691	(AIR) carboxylase
DMSX03_RS01055	COG1606	tRNA processing
DMSX03_RS01060	COG3875	lactate racemase activity
DMSX03_RS01070	COG1929	Belongs to the glycerate kinase type-1 family
DMSX03_RS01075	COG3835	regulator
DMSX03_RS01080	COG0574	Belongs to the PEP-utilizing enzyme family
DMSX03_RS01080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DMSX03_RS01085	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DMSX03_RS01090	COG2764	glyoxalase bleomycin resistance protein dioxygenase
DMSX03_RS01110	COG1476	TRANSCRIPTIONal
DMSX03_RS01115	COG2807	transmembrane transport
DMSX03_RS01125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DMSX03_RS01130	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DMSX03_RS01135	COG1012	belongs to the aldehyde dehydrogenase family
DMSX03_RS01140	COG0531	amino acid
DMSX03_RS01160	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DMSX03_RS01165	COG1510	regulation of RNA biosynthetic process
DMSX03_RS01170	COG1012	belongs to the aldehyde dehydrogenase family
DMSX03_RS01175	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DMSX03_RS01180	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DMSX03_RS01180	COG0463	Glycosyl transferase, family 2
DMSX03_RS01190	COG0778	Nitroreductase
DMSX03_RS01195	COG2843	Capsule synthesis protein
DMSX03_RS01205	COG0477	Major facilitator Superfamily
DMSX03_RS01210	COG0531	amino acid
DMSX03_RS01215	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DMSX03_RS01220	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DMSX03_RS01225	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DMSX03_RS01230	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DMSX03_RS01235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DMSX03_RS01245	COG0431	NADPH-dependent FMN reductase
DMSX03_RS01260	COG2610	gluconate transmembrane transporter activity
DMSX03_RS01265	COG1063	alcohol dehydrogenase
DMSX03_RS01270	COG1620	l-lactate permease
DMSX03_RS01275	COG2814	Major facilitator Superfamily
DMSX03_RS01285	COG1263	PTS System
DMSX03_RS01285	COG2190	(PTS) system
DMSX03_RS01285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DMSX03_RS01290	COG0363	glucosamine-6-phosphate deaminase activity
DMSX03_RS01295	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DMSX03_RS01310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DMSX03_RS01315	COG0765	amino acid transport
DMSX03_RS01320	COG1126	abc transporter atp-binding protein
DMSX03_RS01325	COG3711	transcriptional antiterminator
DMSX03_RS01330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DMSX03_RS01340	COG3037	sugar-specific permease SgaT UlaA
DMSX03_RS01345	COG4297	protein containing double-stranded beta helix domain
DMSX03_RS01355	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DMSX03_RS01365	COG1464	Belongs to the NlpA lipoprotein family
DMSX03_RS01370	COG0039	L-malate dehydrogenase activity
DMSX03_RS01385	COG3711	transcriptional antiterminator
DMSX03_RS01385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DMSX03_RS01390	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DMSX03_RS01390	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DMSX03_RS01390	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DMSX03_RS01395	COG1482	cell wall glycoprotein biosynthetic process
DMSX03_RS01400	COG1940	carbohydrate kinase activity
DMSX03_RS01420	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DMSX03_RS01425	COG0626	cystathionine gamma-synthase activity
DMSX03_RS01450	COG0829	nickel cation binding
DMSX03_RS01455	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
DMSX03_RS01460	COG0830	nickel cation binding
DMSX03_RS01465	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
DMSX03_RS01470	COG0804	urea catabolic process
DMSX03_RS01475	COG0832	Belongs to the urease beta subunit family
DMSX03_RS01480	COG0831	urea catabolic process
DMSX03_RS01485	COG4413	Urea transporter
DMSX03_RS01490	COG0747	negative chemotaxis
DMSX03_RS01515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DMSX03_RS01525	COG0531	amino acid
DMSX03_RS01530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DMSX03_RS01540	COG0561	phosphatase activity
DMSX03_RS01550	COG0167	dihydroorotate dehydrogenase activity
DMSX03_RS01555	COG3001	Fructosamine kinase
DMSX03_RS01580	COG0697	spore germination
DMSX03_RS01585	COG1113	amino acid transport
DMSX03_RS01600	COG3189	MarR family transcriptional regulator
DMSX03_RS01615	COG1388	LysM domain
DMSX03_RS01620	COG0436	Aminotransferase
DMSX03_RS01630	COG2608	mercury ion transmembrane transporter activity
DMSX03_RS01635	COG2217	Heavy metal translocating P-type atpase
DMSX03_RS01640	COG0659	secondary active sulfate transmembrane transporter activity
DMSX03_RS01645	COG1136	(ABC) transporter
DMSX03_RS01650	COG0577	efflux transmembrane transporter activity
DMSX03_RS01655	COG1028	Short-chain dehydrogenase reductase Sdr
DMSX03_RS01665	COG0471	metal ion transport
DMSX03_RS01670	COG5505	Protein of unknown function (DUF819)
DMSX03_RS01685	COG4336	lyase activity
DMSX03_RS01695	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
DMSX03_RS01700	COG1012	belongs to the aldehyde dehydrogenase family
DMSX03_RS01710	COG2409	Drug exporters of the RND superfamily
DMSX03_RS01725	COG1473	amidohydrolase
DMSX03_RS01750	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DMSX03_RS01755	COG3655	Transcriptional regulator
DMSX03_RS01765	COG3425	synthase
DMSX03_RS01780	COG3386	PFAM SMP-30 Gluconolaconase
DMSX03_RS01785	COG3942	CHAP domain
DMSX03_RS01790	COG1757	Na H antiporter
DMSX03_RS01795	COG0583	DNA-binding transcription factor activity
DMSX03_RS01800	COG1380	Effector of murein hydrolase LrgA
DMSX03_RS01810	COG0028	Belongs to the TPP enzyme family
DMSX03_RS01815	COG1288	antiporter activity
DMSX03_RS01820	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DMSX03_RS01820	COG2190	(PTS) system
DMSX03_RS01820	COG1263	PTS System
DMSX03_RS01835	COG2515	1-aminocyclopropane-1-carboxylate deaminase
DMSX03_RS01855	COG0657	acetylesterase activity
DMSX03_RS01870	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DMSX03_RS01880	COG2843	Capsule synthesis protein
DMSX03_RS01900	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DMSX03_RS01905	COG1063	alcohol dehydrogenase
DMSX03_RS01910	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DMSX03_RS01930	COG1129	ABC transporter
DMSX03_RS01950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DMSX03_RS01960	COG3764	Sortase (surface protein transpeptidase)
DMSX03_RS01965	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
DMSX03_RS01970	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DMSX03_RS01980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DMSX03_RS01985	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DMSX03_RS01990	COG2249	NAD(P)H dehydrogenase (quinone) activity
DMSX03_RS01995	COG0561	phosphatase activity
DMSX03_RS02000	COG0778	Nitroreductase
DMSX03_RS02005	COG2514	catechol 2,3-dioxygenase activity
DMSX03_RS02015	COG1132	(ABC) transporter
DMSX03_RS02020	COG1132	(ABC) transporter
DMSX03_RS02030	COG0803	Belongs to the bacterial solute-binding protein 9 family
DMSX03_RS02035	COG1012	belongs to the aldehyde dehydrogenase family
DMSX03_RS02040	COG1846	Transcriptional regulator
DMSX03_RS02045	COG0346	lactoylglutathione lyase activity
DMSX03_RS02050	COG0346	lactoylglutathione lyase activity
DMSX03_RS02055	COG0400	carboxylic ester hydrolase activity
DMSX03_RS02065	COG0471	metal ion transport
DMSX03_RS02070	COG3949	Membrane
DMSX03_RS02080	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
DMSX03_RS02085	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DMSX03_RS02090	COG0586	Pfam SNARE associated Golgi protein
DMSX03_RS02095	COG2271	Major facilitator Superfamily
DMSX03_RS02105	COG3527	Alpha-acetolactate decarboxylase
DMSX03_RS02110	COG1289	transmembrane transporter activity
DMSX03_RS02125	COG4876	unkown
DMSX03_RS02130	COG2357	RelA SpoT domain protein
DMSX03_RS02140	COG1802	Transcriptional regulator
DMSX03_RS02145	COG1070	Carbohydrate kinase
DMSX03_RS02150	COG2610	gluconate transmembrane transporter activity
DMSX03_RS02155	COG1028	Short-chain dehydrogenase reductase Sdr
DMSX03_RS02160	COG3949	Membrane
DMSX03_RS02170	COG2211	Major facilitator Superfamily
DMSX03_RS02175	COG3250	beta-galactosidase activity
DMSX03_RS02195	COG2211	Major facilitator Superfamily
DMSX03_RS02200	COG1904	glucuronate isomerase
DMSX03_RS02205	COG1312	Catalyzes the dehydration of D-mannonate
DMSX03_RS02220	COG4221	oxidoreductase activity
DMSX03_RS02250	COG0107	imidazoleglycerol-phosphate synthase activity
DMSX03_RS02255	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DMSX03_RS02260	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DMSX03_RS02265	COG0131	Imidazoleglycerol-phosphate dehydratase
DMSX03_RS02270	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DMSX03_RS02275	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DMSX03_RS02280	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DMSX03_RS02290	COG3048	D-serine ammonia-lyase activity
DMSX03_RS02295	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DMSX03_RS02300	COG0248	Ppx GppA phosphatase
DMSX03_RS02305	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
DMSX03_RS02310	COG1028	Short-chain dehydrogenase reductase Sdr
DMSX03_RS02315	COG1363	Peptidase, m42
DMSX03_RS02325	COG0069	glutamate synthase activity
DMSX03_RS02335	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DMSX03_RS02340	COG0390	transport system, permease component
DMSX03_RS02345	COG2814	Major facilitator Superfamily
DMSX03_RS02350	COG2851	Citrate transporter
DMSX03_RS02355	COG0531	amino acid
DMSX03_RS02360	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
DMSX03_RS02365	COG1309	transcriptional regulator
DMSX03_RS02370	COG3246	L-lysine catabolic process to acetate
DMSX03_RS02375	COG1250	3-hydroxyacyl-CoA dehydrogenase
DMSX03_RS02390	COG1174	glycine betaine transport
DMSX03_RS02400	COG1174	glycine betaine transport
DMSX03_RS02410	COG1346	cytolysis
DMSX03_RS02415	COG1380	Effector of murein hydrolase LrgA
DMSX03_RS02420	COG3279	Response regulator of the LytR AlgR family
DMSX03_RS02425	COG3275	phosphorelay sensor kinase activity
DMSX03_RS02435	COG4187	Peptidase family M20/M25/M40
DMSX03_RS02455	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DMSX03_RS02465	COG0706	membrane insertase activity
DMSX03_RS02470	COG0025	NhaP-type Na H and K H
DMSX03_RS02490	COG2814	Major facilitator Superfamily
DMSX03_RS02500	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DMSX03_RS02505	COG1388	LysM domain
DMSX03_RS02510	COG0588	phosphoglycerate mutase activity
DMSX03_RS02520	COG2814	Major facilitator Superfamily
DMSX03_RS02535	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DMSX03_RS02540	COG0803	Belongs to the bacterial solute-binding protein 9 family
DMSX03_RS02540	COG3443	Belongs to the bacterial solute-binding protein 9 family
DMSX03_RS02545	COG2353	YceI-like domain
DMSX03_RS02555	COG1695	Transcriptional regulator
DMSX03_RS02575	COG2723	6-phospho-beta-galactosidase activity
DMSX03_RS02580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DMSX03_RS02580	COG2190	(PTS) system
DMSX03_RS02580	COG1263	PTS System
DMSX03_RS02585	COG2188	Transcriptional regulator
DMSX03_RS02590	COG2116	formate transmembrane transporter activity
DMSX03_RS02595	COG0454	-acetyltransferase
DMSX03_RS02610	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DMSX03_RS02615	COG2146	nitrite reductase [NAD(P)H] activity
DMSX03_RS02630	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DMSX03_RS02635	COG1140	nitrate reductase beta subunit
DMSX03_RS02645	COG2181	nitrate reductase activity
DMSX03_RS02655	COG4585	Histidine kinase
DMSX03_RS02665	COG2223	nitrite transmembrane transporter activity
DMSX03_RS02680	COG1846	Transcriptional regulator
DMSX03_RS02705	COG1263	PTS System
DMSX03_RS02705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DMSX03_RS02725	COG1283	sodium-dependent phosphate transmembrane transporter activity
DMSX03_RS02730	COG1028	Short-chain dehydrogenase reductase Sdr
DMSX03_RS02735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DMSX03_RS02740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DMSX03_RS02745	COG1288	antiporter activity
DMSX03_RS02750	COG1349	DNA-binding transcription factor activity
DMSX03_RS02755	COG1063	alcohol dehydrogenase
DMSX03_RS02760	COG2376	Dihydroxyacetone kinase
DMSX03_RS02770	COG0698	ribose 5-phosphate isomerase
DMSX03_RS02780	COG0492	ferredoxin-NADP+ reductase activity
DMSX03_RS02790	COG2814	Major facilitator Superfamily
DMSX03_RS02795	COG0604	alcohol dehydrogenase
DMSX03_RS02815	COG1620	l-lactate permease
DMSX03_RS02820	COG0438	transferase activity, transferring glycosyl groups
DMSX03_RS02830	COG5002	protein histidine kinase activity
DMSX03_RS02830	COG3850	Histidine kinase
DMSX03_RS02835	COG0745	RESPONSE REGULATOR receiver
DMSX03_RS02840	COG0577	efflux transmembrane transporter activity
DMSX03_RS02845	COG1136	(ABC) transporter
DMSX03_RS02860	COG4640	response to antibiotic
DMSX03_RS02865	COG2814	Major facilitator Superfamily
DMSX03_RS02875	COG1566	PFAM secretion protein HlyD family protein
DMSX03_RS02880	COG2814	Major facilitator Superfamily
DMSX03_RS02905	COG0598	Magnesium transport protein CorA
DMSX03_RS02910	COG1304	FMN binding
DMSX03_RS02915	COG0786	glutamate:sodium symporter activity
DMSX03_RS02920	COG1757	Na H antiporter
DMSX03_RS02925	COG2094	Belongs to the DNA glycosylase MPG family
DMSX03_RS02930	COG3152	Membrane
DMSX03_RS02935	COG1069	ribulokinase activity
DMSX03_RS02940	COG4152	abc transporter atp-binding protein
DMSX03_RS02945	COG1668	transmembrane transport
DMSX03_RS02950	COG2017	converts alpha-aldose to the beta-anomer
DMSX03_RS02955	COG2258	MOSC domain
DMSX03_RS02960	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DMSX03_RS02965	COG1266	CAAX protease self-immunity
DMSX03_RS02970	COG0010	Belongs to the arginase family
DMSX03_RS02975	COG0583	DNA-binding transcription factor activity
DMSX03_RS02980	COG3314	Sporulation integral membrane protein YlbJ
DMSX03_RS02985	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DMSX03_RS02990	COG1228	amidohydrolase
DMSX03_RS02995	COG0659	secondary active sulfate transmembrane transporter activity
DMSX03_RS03000	COG1473	amidohydrolase
DMSX03_RS03005	COG1028	Short-chain dehydrogenase reductase Sdr
DMSX03_RS03010	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DMSX03_RS03030	COG1263	PTS System
DMSX03_RS03030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DMSX03_RS03040	COG0385	Bile acid
DMSX03_RS03045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DMSX03_RS03070	COG1113	amino acid transport
DMSX03_RS03075	COG1785	Belongs to the alkaline phosphatase family
DMSX03_RS03085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DMSX03_RS03085	COG1263	PTS System
DMSX03_RS03090	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DMSX03_RS03115	COG1316	TRANSCRIPTIONal
DMSX03_RS03120	COG3383	formate dehydrogenase (NAD+) activity
DMSX03_RS03145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DMSX03_RS03150	COG2076	Multidrug Resistance protein
DMSX03_RS03155	COG2076	Multidrug Resistance protein
DMSX03_RS03160	COG3942	CHAP domain
DMSX03_RS03175	COG1757	Na H antiporter
DMSX03_RS03180	COG3942	CHAP domain
DMSX03_RS03205	COG0765	amino acid transport
DMSX03_RS03210	COG0765	amino acid transport
DMSX03_RS03215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DMSX03_RS03220	COG1126	abc transporter atp-binding protein
DMSX03_RS03225	COG1960	acyl-CoA dehydrogenase activity
DMSX03_RS03230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DMSX03_RS03235	COG1268	BioY protein
DMSX03_RS03245	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DMSX03_RS03250	COG1609	Transcriptional regulator
DMSX03_RS03255	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DMSX03_RS03260	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DMSX03_RS03265	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
DMSX03_RS03270	COG0725	ABC transporter, periplasmic molybdate-binding protein
DMSX03_RS03280	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DMSX03_RS03285	COG1510	regulation of RNA biosynthetic process
DMSX03_RS03290	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DMSX03_RS03295	COG0521	Mo-molybdopterin cofactor biosynthetic process
DMSX03_RS03300	COG0315	cyclic pyranopterin monophosphate synthase activity
DMSX03_RS03325	COG0746	molybdenum cofactor guanylyltransferase activity
DMSX03_RS03330	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DMSX03_RS03355	COG2348	transferase activity, transferring amino-acyl groups
DMSX03_RS03360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DMSX03_RS03385	COG4975	Glucose uptake
DMSX03_RS03395	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DMSX03_RS03395	COG0551	DNA topoisomerase type I activity
DMSX03_RS03400	COG2252	PERMEase
DMSX03_RS03410	COG0051	transcription antitermination factor activity, RNA binding
DMSX03_RS03415	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DMSX03_RS03420	COG0088	Forms part of the polypeptide exit tunnel
DMSX03_RS03425	COG0089	rRNA binding
DMSX03_RS03430	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DMSX03_RS03435	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DMSX03_RS03440	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DMSX03_RS03445	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DMSX03_RS03450	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DMSX03_RS03455	COG0255	Belongs to the universal ribosomal protein uL29 family
DMSX03_RS03460	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DMSX03_RS03465	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DMSX03_RS03470	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DMSX03_RS03475	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DMSX03_RS03480	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DMSX03_RS03485	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DMSX03_RS03490	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DMSX03_RS03495	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DMSX03_RS03500	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DMSX03_RS03505	COG1841	ribosomal large subunit assembly
DMSX03_RS03510	COG0200	Binds to the 23S rRNA
DMSX03_RS03515	COG0201	protein transport
DMSX03_RS03530	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DMSX03_RS03535	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DMSX03_RS03540	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DMSX03_RS03545	COG0202	RNA polymerase activity
DMSX03_RS03550	COG0203	ribosomal protein L17
DMSX03_RS03555	COG1122	ATPase activity
DMSX03_RS03560	COG1122	ATPase activity
DMSX03_RS03570	COG0101	tRNA pseudouridine synthase activity
DMSX03_RS03575	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DMSX03_RS03580	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DMSX03_RS03590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DMSX03_RS03595	COG2130	NADP-dependent
DMSX03_RS03600	COG0604	alcohol dehydrogenase
DMSX03_RS03605	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DMSX03_RS03620	COG1302	Protein conserved in bacteria
DMSX03_RS03625	COG4264	IucA IucC family
DMSX03_RS03630	COG2814	Major facilitator Superfamily
DMSX03_RS03635	COG4264	IucA IucC family
DMSX03_RS03640	COG3457	Alanine racemase
DMSX03_RS03645	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DMSX03_RS03650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DMSX03_RS03655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DMSX03_RS03660	COG3314	Sporulation integral membrane protein YlbJ
DMSX03_RS03665	COG2329	Antibiotic biosynthesis monooxygenase
DMSX03_RS03675	COG1988	membrane-bound metal-dependent
DMSX03_RS03680	COG4284	Utp--glucose-1-phosphate uridylyltransferase
DMSX03_RS03685	COG1272	protein, Hemolysin III
DMSX03_RS03700	COG0489	protein tyrosine kinase activity
DMSX03_RS03755	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DMSX03_RS03765	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DMSX03_RS03770	COG0246	Mannitol dehydrogenase
DMSX03_RS03780	COG3711	transcriptional antiterminator
DMSX03_RS03785	COG2213	PTS system mannitol-specific
DMSX03_RS03800	COG1119	ATPase activity
DMSX03_RS03825	COG0640	Transcriptional regulator
DMSX03_RS03830	COG0702	epimerase
DMSX03_RS03835	COG2186	Transcriptional regulator
DMSX03_RS03840	COG1482	cell wall glycoprotein biosynthetic process
DMSX03_RS03850	COG2855	membrane
DMSX03_RS03865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DMSX03_RS03870	COG0783	Belongs to the Dps family
DMSX03_RS03875	COG0813	purine-nucleoside phosphorylase activity
DMSX03_RS03880	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DMSX03_RS03885	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DMSX03_RS03890	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DMSX03_RS03900	COG1854	S-ribosylhomocysteine lyase activity
DMSX03_RS03920	COG5146	pantothenate kinase activity
DMSX03_RS03925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DMSX03_RS03935	COG0504	CTP synthase activity
DMSX03_RS03940	COG0191	fructose-bisphosphate aldolase activity
DMSX03_RS03945	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DMSX03_RS03955	COG1012	belongs to the aldehyde dehydrogenase family
DMSX03_RS03960	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DMSX03_RS03965	COG0254	rRNA binding
DMSX03_RS03970	COG1435	thymidine kinase activity
DMSX03_RS03975	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DMSX03_RS03980	COG2890	protein-(glutamine-N5) methyltransferase activity
DMSX03_RS03985	COG0009	L-threonylcarbamoyladenylate synthase
DMSX03_RS03990	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DMSX03_RS03995	COG4475	Protein of unknown function (DUF436)
DMSX03_RS04000	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DMSX03_RS04005	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DMSX03_RS04010	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DMSX03_RS04020	COG0356	it plays a direct role in the translocation of protons across the membrane
DMSX03_RS04025	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DMSX03_RS04030	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DMSX03_RS04035	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DMSX03_RS04040	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DMSX03_RS04045	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DMSX03_RS04050	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DMSX03_RS04055	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DMSX03_RS04065	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DMSX03_RS04070	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DMSX03_RS04080	COG0629	single-stranded DNA binding
DMSX03_RS04085	COG1388	LysM domain
DMSX03_RS04090	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DMSX03_RS04100	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DMSX03_RS04105	COG0352	thiamine-phosphate diphosphorylase activity
DMSX03_RS04110	COG0706	membrane insertase activity
DMSX03_RS04115	COG1418	mRNA catabolic process
DMSX03_RS04125	COG1937	Protein conserved in bacteria
DMSX03_RS04140	COG0772	Belongs to the SEDS family
DMSX03_RS04145	COG1181	Belongs to the D-alanine--D-alanine ligase family
DMSX03_RS04150	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DMSX03_RS04155	COG0513	Belongs to the DEAD box helicase family
DMSX03_RS04165	COG3428	Bacterial PH domain
DMSX03_RS04180	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DMSX03_RS04190	COG2337	Toxic component of a toxin-antitoxin (TA) module
DMSX03_RS04195	COG2208	phosphoserine phosphatase activity
DMSX03_RS04210	COG1191	sigma factor activity
DMSX03_RS04215	COG2183	response to ionizing radiation
DMSX03_RS04220	COG3091	SprT-like family
DMSX03_RS04250	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DMSX03_RS04255	COG0066	3-isopropylmalate dehydratase activity
DMSX03_RS04260	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DMSX03_RS04265	COG0473	3-isopropylmalate dehydrogenase activity
DMSX03_RS04270	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DMSX03_RS04275	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DMSX03_RS04280	COG0440	acetolactate synthase activity
DMSX03_RS04285	COG0028	Belongs to the TPP enzyme family
DMSX03_RS04290	COG0129	dihydroxy-acid dehydratase activity
DMSX03_RS04295	COG0802	atpase or kinase
DMSX03_RS04300	COG1214	PFAM Peptidase M22, glycoprotease
DMSX03_RS04305	COG0456	acetyltransferase
DMSX03_RS04310	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DMSX03_RS04320	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DMSX03_RS04325	COG0488	(ABC) transporter
DMSX03_RS04330	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DMSX03_RS04335	COG2391	methyltransferase activity
DMSX03_RS04340	COG0425	Belongs to the sulfur carrier protein TusA family
DMSX03_RS04345	COG1609	Transcriptional regulator
DMSX03_RS04350	COG1621	beta-fructofuranosidase activity
DMSX03_RS04355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DMSX03_RS04360	COG3279	Response regulator of the LytR AlgR family
DMSX03_RS04365	COG3290	protein histidine kinase activity
DMSX03_RS04375	COG4512	PFAM Accessory gene regulator B
DMSX03_RS04380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DMSX03_RS04400	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DMSX03_RS04405	COG0459	protein refolding
DMSX03_RS04425	COG1725	Transcriptional regulator
DMSX03_RS04440	COG1131	(ABC) transporter
DMSX03_RS04490	COG4974	Belongs to the 'phage' integrase family
DMSX03_RS04515	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DMSX03_RS04520	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DMSX03_RS04535	COG0640	Transcriptional regulator
DMSX03_RS04550	COG2706	6-phosphogluconolactonase activity
DMSX03_RS04555	COG1012	belongs to the aldehyde dehydrogenase family
DMSX03_RS04560	COG1227	inorganic diphosphatase activity
DMSX03_RS04565	COG1335	isochorismatase
DMSX03_RS04575	COG0471	metal ion transport
DMSX03_RS04580	COG0077	Prephenate dehydratase
DMSX03_RS04590	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DMSX03_RS04595	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DMSX03_RS04600	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
DMSX03_RS04610	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DMSX03_RS04615	COG4496	protein, YerC YecD
DMSX03_RS04620	COG1876	peptidase activity
DMSX03_RS04625	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
DMSX03_RS04635	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DMSX03_RS04640	COG4851	CamS sex pheromone cAM373 precursor
DMSX03_RS04645	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DMSX03_RS04650	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DMSX03_RS04655	COG0154	amidase activity
DMSX03_RS04660	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DMSX03_RS04665	COG1597	lipid kinase activity
DMSX03_RS04670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DMSX03_RS04680	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DMSX03_RS04690	COG1528	Iron-storage protein
DMSX03_RS04705	COG4129	membrane
DMSX03_RS04710	COG0024	Methionine aminopeptidase
DMSX03_RS04725	COG4585	Histidine kinase
DMSX03_RS04730	COG2197	response regulator
DMSX03_RS04735	COG1295	ribonuclease BN
DMSX03_RS04745	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DMSX03_RS04750	COG4840	Belongs to the UPF0435 family
DMSX03_RS04755	COG2309	aminopeptidase activity
DMSX03_RS04760	COG1607	acyl-coa hydrolase
DMSX03_RS04765	COG0535	radical SAM domain protein
DMSX03_RS04775	COG0693	protein deglycase activity
DMSX03_RS04780	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DMSX03_RS04785	COG2137	regulation of response to DNA damage stimulus
DMSX03_RS04795	COG1134	teichoic acid transport
DMSX03_RS04805	COG1988	membrane-bound metal-dependent
DMSX03_RS04815	COG3557	Belongs to the UPF0374 family
DMSX03_RS04825	COG4129	membrane
DMSX03_RS04830	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DMSX03_RS04835	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DMSX03_RS04840	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DMSX03_RS04845	COG0735	belongs to the Fur family
DMSX03_RS04995	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DMSX03_RS05010	COG0765	amino acid transport
DMSX03_RS05015	COG1126	abc transporter atp-binding protein
DMSX03_RS05020	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DMSX03_RS05030	COG0363	glucosamine-6-phosphate deaminase activity
DMSX03_RS05045	COG0114	fumarate hydratase activity
DMSX03_RS05050	COG0564	pseudouridine synthase activity
DMSX03_RS05055	COG4585	Histidine kinase
DMSX03_RS05055	COG2203	Gaf domain
DMSX03_RS05060	COG2197	response regulator
DMSX03_RS05065	COG1301	dicarboxylic acid transport
DMSX03_RS05070	COG0772	Belongs to the SEDS family
DMSX03_RS05075	COG1316	TRANSCRIPTIONal
DMSX03_RS05080	COG0730	response to heat
DMSX03_RS05090	COG1682	transport, permease protein
DMSX03_RS05105	COG0788	formyltetrahydrofolate deformylase activity
DMSX03_RS05115	COG4399	Belongs to the UPF0754 family
DMSX03_RS05120	COG3679	Belongs to the UPF0342 family
DMSX03_RS05125	COG0420	3'-5' exonuclease activity
DMSX03_RS05130	COG4717	serine-type aminopeptidase activity
DMSX03_RS05135	COG3481	metal-dependent phosphohydrolase, HD sub domain
DMSX03_RS05140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DMSX03_RS05155	COG0537	adenosine 5'-monophosphoramidase activity
DMSX03_RS05160	COG1131	(ABC) transporter
DMSX03_RS05165	COG4473	ABC transporter
DMSX03_RS05175	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DMSX03_RS05180	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
DMSX03_RS05185	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
DMSX03_RS05190	COG3545	Serine hydrolase
DMSX03_RS05270	COG0300	oxidoreductase activity
DMSX03_RS05300	COG0318	PFAM AMP-dependent synthetase and ligase
DMSX03_RS05310	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DMSX03_RS05320	COG1506	peptidase
DMSX03_RS05325	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DMSX03_RS05330	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DMSX03_RS05340	COG0656	L-ascorbic acid biosynthetic process
DMSX03_RS05345	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DMSX03_RS05350	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DMSX03_RS05360	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DMSX03_RS05380	COG1595	DNA-templated transcription, initiation
DMSX03_RS05390	COG3266	domain, Protein
DMSX03_RS05390	COG4193	domain, Protein
DMSX03_RS05390	COG5632	N-Acetylmuramoyl-L-alanine amidase
DMSX03_RS05405	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DMSX03_RS05405	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DMSX03_RS05410	COG0307	riboflavin synthase, alpha
DMSX03_RS05415	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DMSX03_RS05415	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DMSX03_RS05420	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DMSX03_RS05430	COG2267	carboxylic ester hydrolase activity
DMSX03_RS05435	COG0039	L-malate dehydrogenase activity
DMSX03_RS05445	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DMSX03_RS05450	COG1242	4 iron, 4 sulfur cluster binding
DMSX03_RS05455	COG2814	Major facilitator Superfamily
DMSX03_RS05460	COG0495	leucyl-tRNA aminoacylation
DMSX03_RS05470	COG2081	HI0933 family
DMSX03_RS05475	COG2244	polysaccharide biosynthetic process
DMSX03_RS05480	COG1187	pseudouridine synthase activity
DMSX03_RS05490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DMSX03_RS05495	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DMSX03_RS05500	COG0510	thiamine kinase activity
DMSX03_RS05505	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DMSX03_RS05510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DMSX03_RS05520	COG1363	Peptidase, m42
DMSX03_RS05525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DMSX03_RS05530	COG4848	Belongs to the UPF0354 family
DMSX03_RS05535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DMSX03_RS05540	COG1674	ftsk spoiiie
DMSX03_RS05545	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DMSX03_RS05550	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
DMSX03_RS05560	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DMSX03_RS05560	COG1605	Chorismate mutase
DMSX03_RS05565	COG1609	Transcriptional regulator
DMSX03_RS05570	COG0123	including yeast histone deacetylase and acetoin utilization protein
DMSX03_RS05575	COG0454	-acetyltransferase
DMSX03_RS05580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DMSX03_RS05595	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DMSX03_RS05600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMSX03_RS05605	COG0204	Acyl-transferase
DMSX03_RS05610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DMSX03_RS05610	COG1263	PTS System
DMSX03_RS05620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DMSX03_RS05625	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DMSX03_RS05630	COG1764	response to oxidative stress
DMSX03_RS05635	COG0584	glycerophosphoryl diester phosphodiesterase
DMSX03_RS05640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DMSX03_RS05645	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DMSX03_RS05650	COG1956	GAF domain-containing protein
DMSX03_RS05655	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
DMSX03_RS05660	COG1104	cysteine desulfurase activity
DMSX03_RS05665	COG0301	tRNA thio-modification
DMSX03_RS05675	COG0616	signal peptide processing
DMSX03_RS05680	COG1714	RDD family
DMSX03_RS05685	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DMSX03_RS05690	COG0827	DNA restriction-modification system
DMSX03_RS05695	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DMSX03_RS05705	COG0589	response to stress
DMSX03_RS05710	COG0686	Belongs to the AlaDH PNT family
DMSX03_RS05715	COG3142	Participates in the control of copper homeostasis
DMSX03_RS05720	COG0006	proline dipeptidase activity
DMSX03_RS05725	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DMSX03_RS05735	COG4109	DRTGG domain
DMSX03_RS05740	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DMSX03_RS05745	COG0587	DNA-directed DNA polymerase activity
DMSX03_RS05750	COG0281	malic enzyme
DMSX03_RS05755	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DMSX03_RS05760	COG0825	malonyl-CoA metabolic process
DMSX03_RS05765	COG0205	6-phosphofructokinase activity
DMSX03_RS05770	COG0469	pyruvate kinase activity
DMSX03_RS05775	COG1113	amino acid transport
DMSX03_RS05780	COG0372	Belongs to the citrate synthase family
DMSX03_RS05785	COG0538	isocitrate dehydrogenase activity
DMSX03_RS05790	COG0745	RESPONSE REGULATOR receiver
DMSX03_RS05795	COG5002	protein histidine kinase activity
DMSX03_RS05800	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DMSX03_RS05800	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DMSX03_RS05810	COG0237	dephospho-CoA kinase activity
DMSX03_RS05815	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DMSX03_RS05820	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DMSX03_RS05830	COG1484	DNA-dependent DNA replication
DMSX03_RS05835	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DMSX03_RS05840	COG0833	amino acid
DMSX03_RS05845	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DMSX03_RS05850	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DMSX03_RS05855	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DMSX03_RS05860	COG4112	unkown
DMSX03_RS05870	COG0544	peptidyl-prolyl cis-trans isomerase activity
DMSX03_RS05875	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DMSX03_RS05880	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DMSX03_RS05885	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DMSX03_RS05890	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DMSX03_RS05895	COG0181	hydroxymethylbilane synthase activity
DMSX03_RS05905	COG0113	porphobilinogen synthase activity
DMSX03_RS05910	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DMSX03_RS05920	COG2818	Glycosylase
DMSX03_RS05925	COG0525	valine-tRNA ligase activity
DMSX03_RS05930	COG0285	dihydrofolate synthase activity
DMSX03_RS05945	COG2003	Belongs to the UPF0758 family
DMSX03_RS05975	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DMSX03_RS05980	COG2868	ribosomal protein
DMSX03_RS05985	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DMSX03_RS05990	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DMSX03_RS05995	COG4492	Belongs to the UPF0735 family
DMSX03_RS06000	COG0632	four-way junction helicase activity
DMSX03_RS06005	COG2255	four-way junction helicase activity
DMSX03_RS06010	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DMSX03_RS06015	COG0343	queuine tRNA-ribosyltransferase activity
DMSX03_RS06020	COG1862	Preprotein translocase
DMSX03_RS06025	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DMSX03_RS06025	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DMSX03_RS06030	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DMSX03_RS06030	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DMSX03_RS06040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DMSX03_RS06045	COG1490	D-aminoacyl-tRNA deacylase activity
DMSX03_RS06050	COG0860	N-Acetylmuramoyl-L-alanine amidase
DMSX03_RS06055	COG0124	histidyl-tRNA synthetase
DMSX03_RS06060	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DMSX03_RS06070	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DMSX03_RS06075	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DMSX03_RS06080	COG1959	2 iron, 2 sulfur cluster binding
DMSX03_RS06095	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DMSX03_RS06100	COG0488	(ABC) transporter
DMSX03_RS06105	COG1104	cysteine desulfurase activity
DMSX03_RS06110	COG0482	sulfurtransferase activity
DMSX03_RS06120	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DMSX03_RS06125	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DMSX03_RS06130	COG4472	Bacterial protein of unknown function (DUF965)
DMSX03_RS06135	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DMSX03_RS06140	COG3906	Belongs to the UPF0473 family
DMSX03_RS06145	COG4122	O-methyltransferase activity
DMSX03_RS06150	COG0826	peptidase U32
DMSX03_RS06155	COG0826	peptidase U32
DMSX03_RS06160	COG0572	uridine kinase
DMSX03_RS06165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DMSX03_RS06170	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DMSX03_RS06175	COG1984	allophanate hydrolase subunit 2
DMSX03_RS06180	COG0511	ligase activity, forming carbon-carbon bonds
DMSX03_RS06185	COG0439	Biotin carboxylase
DMSX03_RS06190	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DMSX03_RS06195	COG1914	H( )-stimulated, divalent metal cation uptake system
DMSX03_RS06200	COG0730	response to heat
DMSX03_RS06205	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DMSX03_RS06210	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DMSX03_RS06215	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DMSX03_RS06220	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DMSX03_RS06225	COG1534	Rna-binding protein
DMSX03_RS06230	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DMSX03_RS06235	COG1713	HD superfamily hydrolase involved in NAD metabolism
DMSX03_RS06240	COG0799	negative regulation of ribosome biogenesis
DMSX03_RS06245	COG2226	methyltransferase
DMSX03_RS06250	COG1555	photosystem II stabilization
DMSX03_RS06250	COG1596	polysaccharide export
DMSX03_RS06255	COG2131	deaminase
DMSX03_RS06260	COG0658	competence protein
DMSX03_RS06260	COG2333	competence protein COMEC
DMSX03_RS06265	COG1466	dna polymerase III delta subunit
DMSX03_RS06270	COG0268	Binds directly to 16S ribosomal RNA
DMSX03_RS06275	COG0481	GTPase activity
DMSX03_RS06280	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DMSX03_RS06285	COG1420	regulation of RNA biosynthetic process
DMSX03_RS06290	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DMSX03_RS06295	COG0443	Heat shock 70 kDa protein
DMSX03_RS06300	COG0484	heat shock protein binding
DMSX03_RS06305	COG2264	protein methyltransferase activity
DMSX03_RS06310	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DMSX03_RS06315	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DMSX03_RS06320	COG1030	water channel activity
DMSX03_RS06325	COG4864	UPF0365 protein
DMSX03_RS06335	COG1702	phosphate starvation-inducible protein PhoH
DMSX03_RS06340	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DMSX03_RS06345	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DMSX03_RS06350	COG0295	cytidine deaminase activity
DMSX03_RS06355	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DMSX03_RS06360	COG1381	Involved in DNA repair and RecF pathway recombination
DMSX03_RS06365	COG0423	glycine-tRNA ligase activity
DMSX03_RS06370	COG0517	IMP dehydrogenase activity
DMSX03_RS06375	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DMSX03_RS06385	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DMSX03_RS06390	COG2384	SAM-dependent methyltransferase
DMSX03_RS06400	COG0513	Belongs to the DEAD box helicase family
DMSX03_RS06405	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DMSX03_RS06410	COG1121	(ABC) transporter
DMSX03_RS06415	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DMSX03_RS06425	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DMSX03_RS06430	COG0768	penicillin binding
DMSX03_RS06435	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DMSX03_RS06440	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DMSX03_RS06445	COG0457	Tetratricopeptide repeat
DMSX03_RS06445	COG0705	Rhomboid family
DMSX03_RS06450	COG4483	Protein conserved in bacteria
DMSX03_RS06455	COG1940	carbohydrate kinase activity
DMSX03_RS06460	COG0011	TIGRFAM Protein of
DMSX03_RS06465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DMSX03_RS06470	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DMSX03_RS06500	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DMSX03_RS06505	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DMSX03_RS06510	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DMSX03_RS06515	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DMSX03_RS06520	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DMSX03_RS06525	COG0095	Lipoate-protein ligase
DMSX03_RS06540	COG0006	proline dipeptidase activity
DMSX03_RS06545	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DMSX03_RS06550	COG0511	ligase activity, forming carbon-carbon bonds
DMSX03_RS06555	COG0439	Biotin carboxylase
DMSX03_RS06560	COG1302	Protein conserved in bacteria
DMSX03_RS06565	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DMSX03_RS06570	COG1570	exodeoxyribonuclease VII activity
DMSX03_RS06575	COG1722	exodeoxyribonuclease VII activity
DMSX03_RS06585	COG1438	arginine binding
DMSX03_RS06590	COG0497	DNA recombination
DMSX03_RS06595	COG0280	phosphate acetyltransferase
DMSX03_RS06600	COG3426	butyrate kinase activity
DMSX03_RS06605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DMSX03_RS06610	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DMSX03_RS06615	COG0022	dehydrogenase e1 component
DMSX03_RS06620	COG0508	dehydrogenase complex catalyzes the overall conversion of
DMSX03_RS06630	COG4129	membrane
DMSX03_RS06640	COG2195	Cleaves the N-terminal amino acid of tripeptides
DMSX03_RS06650	COG1609	Transcriptional regulator
DMSX03_RS06655	COG0366	Alpha amylase catalytic
DMSX03_RS06665	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DMSX03_RS06670	COG1234	tRNA 3'-trailer cleavage
DMSX03_RS06675	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DMSX03_RS06685	COG0667	Aldo Keto reductase
DMSX03_RS06690	COG0494	nUDIX hydrolase
DMSX03_RS06695	COG0735	belongs to the Fur family
DMSX03_RS06700	COG4974	Belongs to the 'phage' integrase family
DMSX03_RS06710	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DMSX03_RS06715	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DMSX03_RS06720	COG1187	pseudouridine synthase activity
DMSX03_RS06725	COG0745	RESPONSE REGULATOR receiver
DMSX03_RS06740	COG1141	Ferredoxin
DMSX03_RS06750	COG0514	ATP-dependent DNA helicase (RecQ)
DMSX03_RS06755	COG1388	LysM domain
DMSX03_RS06760	COG0492	ferredoxin-NADP+ reductase activity
DMSX03_RS06770	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DMSX03_RS06775	COG0539	negative regulation of cytoplasmic translation
DMSX03_RS06780	COG1160	GTP binding
DMSX03_RS06785	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DMSX03_RS06800	COG2226	methyltransferase
DMSX03_RS06805	COG0142	geranyltranstransferase activity
DMSX03_RS06810	COG0105	UTP biosynthetic process
DMSX03_RS06815	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DMSX03_RS06820	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DMSX03_RS06825	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DMSX03_RS06835	COG5582	Belongs to the UPF0302 family
DMSX03_RS06840	COG4347	Protein of unknown function (DUF1405)
DMSX03_RS06845	COG2738	Putative neutral zinc metallopeptidase
DMSX03_RS06850	COG1694	Mazg nucleotide pyrophosphohydrolase
DMSX03_RS06855	COG0438	transferase activity, transferring glycosyl groups
DMSX03_RS06860	COG0617	tRNA 3'-terminal CCA addition
DMSX03_RS06870	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DMSX03_RS06870	COG1199	ATP-dependent helicase activity
DMSX03_RS06875	COG0017	Asparaginyl-tRNA synthetase
DMSX03_RS06880	COG3935	DnaD domain protein
DMSX03_RS06885	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DMSX03_RS06895	COG4499	WXG100 protein secretion system (Wss), protein YukC
DMSX03_RS06895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DMSX03_RS06900	COG3331	DNA recombination
DMSX03_RS06910	COG4474	Belongs to the UPF0398 family
DMSX03_RS06925	COG0116	Belongs to the methyltransferase superfamily
DMSX03_RS06930	COG2962	Rard protein
DMSX03_RS06940	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DMSX03_RS06945	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DMSX03_RS06955	COG3545	Serine hydrolase
DMSX03_RS06960	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DMSX03_RS06970	COG1413	lyase activity
DMSX03_RS06975	COG1413	lyase activity
DMSX03_RS06985	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DMSX03_RS07005	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DMSX03_RS07015	COG4479	Belongs to the UPF0346 family
DMSX03_RS07020	COG0793	Belongs to the peptidase S41A family
DMSX03_RS07030	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DMSX03_RS07035	COG0671	phosphoesterase, PA-phosphatase related
DMSX03_RS07040	COG0745	RESPONSE REGULATOR receiver
DMSX03_RS07045	COG5002	protein histidine kinase activity
DMSX03_RS07050	COG0567	Dehydrogenase, E1 component
DMSX03_RS07055	COG0508	dehydrogenase complex catalyzes the overall conversion of
DMSX03_RS07065	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DMSX03_RS07075	COG1917	Cupin 2, conserved barrel domain protein
DMSX03_RS07075	COG2207	Transcriptional regulator
DMSX03_RS07100	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DMSX03_RS07105	COG1121	(ABC) transporter
DMSX03_RS07130	COG0714	Associated with various cellular activities
DMSX03_RS07135	COG4548	von Willebrand factor, type A
DMSX03_RS07140	COG1114	Component of the transport system for branched-chain amino acids
DMSX03_RS07145	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DMSX03_RS07150	COG3853	Toxic anion resistance protein (TelA)
DMSX03_RS07160	COG1254	Belongs to the acylphosphatase family
DMSX03_RS07170	COG1278	Cold shock
DMSX03_RS07185	COG1473	amidohydrolase
DMSX03_RS07195	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DMSX03_RS07200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DMSX03_RS07205	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DMSX03_RS07210	COG0527	aspartate kinase activity
DMSX03_RS07220	COG0488	(ABC) transporter
DMSX03_RS07225	COG2996	Protein conserved in bacteria
DMSX03_RS07230	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DMSX03_RS07235	COG0573	inorganic phosphate transmembrane transporter activity
DMSX03_RS07240	COG0581	inorganic phosphate transmembrane transporter activity
DMSX03_RS07245	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DMSX03_RS07250	COG0704	Plays a role in the regulation of phosphate uptake
DMSX03_RS07255	COG1164	Oligoendopeptidase f
DMSX03_RS07265	COG4607	ABC-type enterochelin transport system periplasmic component
DMSX03_RS07280	COG2348	transferase activity, transferring amino-acyl groups
DMSX03_RS07290	COG0159	tryptophan synthase activity
DMSX03_RS07295	COG0133	tryptophan synthase activity
DMSX03_RS07305	COG0134	indole-3-glycerol-phosphate synthase activity
DMSX03_RS07310	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DMSX03_RS07315	COG0512	Glutamine amidotransferase of anthranilate synthase
DMSX03_RS07320	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DMSX03_RS07335	COG0438	transferase activity, transferring glycosyl groups
DMSX03_RS07345	COG2801	Transposase and inactivated derivatives
DMSX03_RS07355	COG2124	cytochrome p450
DMSX03_RS07360	COG0561	phosphatase activity
DMSX03_RS07430	COG4555	ABC transporter
DMSX03_RS07460	COG1363	Peptidase, m42
DMSX03_RS07470	COG0287	Prephenate dehydrogenase
DMSX03_RS07475	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DMSX03_RS07480	COG1942	4-Oxalocrotonate Tautomerase
DMSX03_RS07495	COG1879	ABC-type sugar transport system periplasmic component
DMSX03_RS07500	COG1172	Belongs to the binding-protein-dependent transport system permease family
DMSX03_RS07505	COG1129	ABC transporter
DMSX03_RS07510	COG1869	D-ribose catabolic process
DMSX03_RS07515	COG1609	Transcriptional regulator
DMSX03_RS07525	COG0392	lysyltransferase activity
DMSX03_RS07525	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DMSX03_RS07530	COG0628	permease
DMSX03_RS07540	COG3711	transcriptional antiterminator
DMSX03_RS07545	COG1115	amino acid carrier protein
DMSX03_RS07550	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DMSX03_RS07560	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DMSX03_RS07565	COG4841	protein insertion into membrane
DMSX03_RS07570	COG0824	Thioesterase
DMSX03_RS07575	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DMSX03_RS07580	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DMSX03_RS07585	COG1970	mechanosensitive ion channel activity
DMSX03_RS07590	COG0419	ATPase involved in DNA repair
DMSX03_RS07595	COG0420	3'-5' exonuclease activity
DMSX03_RS07600	COG4846	Membrane protein involved in cytochrome C biogenesis
DMSX03_RS07610	COG3763	UPF0154 protein
DMSX03_RS07630	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DMSX03_RS07640	COG0516	GMP reductase activity
DMSX03_RS07645	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DMSX03_RS07650	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DMSX03_RS07655	COG0753	catalase activity
DMSX03_RS07660	COG0833	amino acid
DMSX03_RS07670	COG0561	phosphatase activity
DMSX03_RS07675	COG0083	homoserine kinase activity
DMSX03_RS07680	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DMSX03_RS07685	COG0460	homoserine dehydrogenase
DMSX03_RS07690	COG0527	aspartate kinase activity
DMSX03_RS07715	COG2801	Transposase and inactivated derivatives
DMSX03_RS07730	COG2197	response regulator
DMSX03_RS07735	COG4585	Histidine kinase
DMSX03_RS07740	COG0842	Transport permease protein
DMSX03_RS07745	COG1131	(ABC) transporter
DMSX03_RS07755	COG2808	Putative FMN-binding domain
DMSX03_RS07760	COG1764	response to oxidative stress
DMSX03_RS07770	COG0789	Transcriptional regulator
DMSX03_RS07775	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DMSX03_RS07780	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DMSX03_RS07785	COG0386	Belongs to the glutathione peroxidase family
DMSX03_RS07790	COG1923	regulation of RNA biosynthetic process
DMSX03_RS07795	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DMSX03_RS07805	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DMSX03_RS07810	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DMSX03_RS07815	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DMSX03_RS07820	COG1619	proteins homologs of microcin C7 resistance protein MccF
DMSX03_RS07830	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DMSX03_RS07835	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DMSX03_RS07845	COG4550	Control of competence regulator ComK, YlbF/YmcA
DMSX03_RS07850	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DMSX03_RS07865	COG1959	2 iron, 2 sulfur cluster binding
DMSX03_RS07870	COG4195	phage-related replication protein
DMSX03_RS07880	COG1013	pyruvate-flavodoxin oxidoreductase activity
DMSX03_RS07885	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DMSX03_RS07885	COG0674	pyruvate-flavodoxin oxidoreductase activity
DMSX03_RS07890	COG1692	metallophosphoesterase
DMSX03_RS07900	COG1418	mRNA catabolic process
DMSX03_RS07905	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DMSX03_RS07910	COG1546	Belongs to the CinA family
DMSX03_RS07910	COG1058	Belongs to the CinA family
DMSX03_RS07930	COG0300	oxidoreductase activity
DMSX03_RS07935	COG0612	Peptidase, M16
DMSX03_RS07940	COG0612	Peptidase, M16
DMSX03_RS07945	COG2188	Transcriptional regulator
DMSX03_RS07950	COG1674	ftsk spoiiie
DMSX03_RS07955	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DMSX03_RS07960	COG1185	polyribonucleotide nucleotidyltransferase activity
DMSX03_RS07965	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DMSX03_RS07970	COG0196	riboflavin kinase activity
DMSX03_RS07975	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DMSX03_RS07980	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DMSX03_RS07995	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DMSX03_RS08000	COG1358	cellular component organization or biogenesis
DMSX03_RS08005	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DMSX03_RS08010	COG0195	Participates in both transcription termination and antitermination
DMSX03_RS08015	COG0779	Required for maturation of 30S ribosomal subunits
DMSX03_RS08020	COG2176	DNA-directed DNA polymerase activity
DMSX03_RS08025	COG0442	prolyl-tRNA aminoacylation
DMSX03_RS08035	COG4589	Belongs to the CDS family
DMSX03_RS08040	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DMSX03_RS08045	COG0233	cytoplasmic translational termination
DMSX03_RS08050	COG0528	UMP kinase activity
DMSX03_RS08055	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DMSX03_RS08060	COG0052	Belongs to the universal ribosomal protein uS2 family
DMSX03_RS08065	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DMSX03_RS08070	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DMSX03_RS08075	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DMSX03_RS08080	COG4974	Belongs to the 'phage' integrase family
DMSX03_RS08085	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DMSX03_RS08090	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DMSX03_RS08095	COG0758	DNA mediated transformation
DMSX03_RS08105	COG0045	succinate-CoA ligase (ADP-forming) activity
DMSX03_RS08110	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DMSX03_RS08120	COG4485	Bacterial membrane protein, YfhO
DMSX03_RS08130	COG0335	large ribosomal subunit rRNA binding
DMSX03_RS08135	COG0336	Belongs to the RNA methyltransferase TrmD family
DMSX03_RS08140	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DMSX03_RS08145	COG0228	four-way junction DNA binding
DMSX03_RS08150	COG1028	Short-chain dehydrogenase reductase Sdr
DMSX03_RS08155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DMSX03_RS08160	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DMSX03_RS08165	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DMSX03_RS08170	COG0552	protein localization to endoplasmic reticulum
DMSX03_RS08175	COG1196	nuclear chromosome segregation
DMSX03_RS08180	COG0571	ribonuclease III activity
DMSX03_RS08185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DMSX03_RS08200	COG0416	fatty acid biosynthetic process
DMSX03_RS08205	COG1349	DNA-binding transcription factor activity
DMSX03_RS08215	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DMSX03_RS08220	COG1760	l-serine dehydratase
DMSX03_RS08225	COG1760	l-serine dehydratase
DMSX03_RS08230	COG1461	Dihydroxyacetone kinase
DMSX03_RS08235	COG1302	Protein conserved in bacteria
DMSX03_RS08240	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DMSX03_RS08245	COG1564	THIamine pyrophosphokinase
DMSX03_RS08250	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DMSX03_RS08255	COG1162	GTPase activity
DMSX03_RS08275	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DMSX03_RS08280	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DMSX03_RS08280	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DMSX03_RS08285	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DMSX03_RS08290	COG0242	peptide deformylase activity
DMSX03_RS08305	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DMSX03_RS08310	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DMSX03_RS08315	COG1758	RNA polymerase activity
DMSX03_RS08320	COG0194	GDP metabolic process
DMSX03_RS08325	COG1293	RNA-binding protein homologous to eukaryotic snRNP
DMSX03_RS08335	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DMSX03_RS08345	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DMSX03_RS08350	COG0284	orotidine-5'-phosphate decarboxylase activity
DMSX03_RS08355	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DMSX03_RS08360	COG0505	Belongs to the CarA family
DMSX03_RS08370	COG0540	Belongs to the ATCase OTCase family
DMSX03_RS08380	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DMSX03_RS08385	COG0564	pseudouridine synthase activity
DMSX03_RS08390	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DMSX03_RS08400	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DMSX03_RS08405	COG3599	regulation of cell shape
DMSX03_RS08415	COG0762	integral membrane protein
DMSX03_RS08420	COG1799	cell septum assembly
DMSX03_RS08425	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DMSX03_RS08430	COG1496	oxidoreductase activity
DMSX03_RS08435	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DMSX03_RS08440	COG0849	cell division
DMSX03_RS08450	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DMSX03_RS08455	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DMSX03_RS08460	COG0768	penicillin binding
DMSX03_RS08465	COG4839	cell division protein FtsL
DMSX03_RS08470	COG0275	rRNA processing
DMSX03_RS08475	COG2001	Belongs to the MraZ family
DMSX03_RS08480	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
DMSX03_RS08485	COG0454	-acetyltransferase
DMSX03_RS08490	COG1011	Hydrolase
DMSX03_RS08555	COG0604	alcohol dehydrogenase
DMSX03_RS08665	COG0052	Belongs to the universal ribosomal protein uS2 family
DMSX03_RS08765	COG3723	Recombinational DNA repair protein, rece pathway
DMSX03_RS08770	COG5377	YqaJ viral recombinase family
DMSX03_RS08830	COG0582	viral genome integration into host DNA
DMSX03_RS08845	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DMSX03_RS08850	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DMSX03_RS08855	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DMSX03_RS08860	COG1053	succinate dehydrogenase
DMSX03_RS08865	COG2009	succinate dehydrogenase
DMSX03_RS08870	COG0322	excinuclease ABC activity
DMSX03_RS08875	COG3118	belongs to the thioredoxin family
DMSX03_RS08880	COG1193	negative regulation of DNA recombination
DMSX03_RS08885	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DMSX03_RS08885	COG1796	DNA polymerase
DMSX03_RS08895	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DMSX03_RS08900	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DMSX03_RS08905	COG0072	phenylalanine-tRNA ligase activity
DMSX03_RS08910	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DMSX03_RS08915	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DMSX03_RS08925	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DMSX03_RS08935	COG1323	Belongs to the UPF0348 family
DMSX03_RS08940	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DMSX03_RS08945	COG0742	ribosomal rna small subunit methyltransferase
DMSX03_RS08955	COG4471	UPF0298 protein
DMSX03_RS08960	COG0584	glycerophosphoryl diester phosphodiesterase
DMSX03_RS08965	COG3679	Belongs to the UPF0342 family
DMSX03_RS08975	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DMSX03_RS08985	COG0109	protoheme IX farnesyltransferase activity
DMSX03_RS08990	COG1612	heme a metabolic process
DMSX03_RS09000	COG0772	Belongs to the SEDS family
DMSX03_RS09005	COG4838	Belongs to the UPF0358 family
DMSX03_RS09010	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DMSX03_RS09015	COG4896	Protein conserved in bacteria
DMSX03_RS09020	COG1217	gtp-binding protein TYPA
DMSX03_RS09030	COG0483	inositol monophosphate 1-phosphatase activity
DMSX03_RS09035	COG4493	Belongs to the UPF0637 family
DMSX03_RS09045	COG1914	H( )-stimulated, divalent metal cation uptake system
DMSX03_RS09060	COG1177	transmembrane transport
DMSX03_RS09065	COG1176	ABC-type spermidine putrescine transport system, permease component I
DMSX03_RS09070	COG3842	ATPase activity
DMSX03_RS09080	COG4476	Belongs to the UPF0223 family
DMSX03_RS09110	COG0242	peptide deformylase activity
DMSX03_RS09120	COG5503	Protein of unknown function (DUF1447)
DMSX03_RS09125	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DMSX03_RS09130	COG0569	domain protein
DMSX03_RS09135	COG1294	oxidase, subunit
DMSX03_RS09140	COG1271	oxidase subunit
DMSX03_RS09150	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DMSX03_RS09155	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DMSX03_RS09165	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DMSX03_RS09180	COG4172	Belongs to the ABC transporter superfamily
DMSX03_RS09190	COG0151	Belongs to the GarS family
DMSX03_RS09195	COG0138	bifunctional purine biosynthesis protein purh
DMSX03_RS09205	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DMSX03_RS09215	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DMSX03_RS09220	COG0047	phosphoribosylformylglycinamidine synthase activity
DMSX03_RS09225	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DMSX03_RS09230	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DMSX03_RS09235	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DMSX03_RS09240	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DMSX03_RS09245	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DMSX03_RS09250	COG1017	nitric oxide dioxygenase activity
DMSX03_RS09250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DMSX03_RS09260	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DMSX03_RS09265	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DMSX03_RS09270	COG1845	cytochrome c oxidase, subunit III
DMSX03_RS09275	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DMSX03_RS09290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DMSX03_RS09295	COG1316	TRANSCRIPTIONal
DMSX03_RS09320	COG3594	Acyltransferase
DMSX03_RS09325	COG0436	Aminotransferase
DMSX03_RS09330	COG1846	Transcriptional regulator
DMSX03_RS09335	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DMSX03_RS09340	COG2267	carboxylic ester hydrolase activity
DMSX03_RS09345	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DMSX03_RS09350	COG1169	isochorismate synthase
DMSX03_RS09355	COG1575	Belongs to the MenA family. Type 1 subfamily
DMSX03_RS09365	COG2314	TM2 domain
DMSX03_RS09385	COG4903	ComK protein
DMSX03_RS09400	COG4873	Protein conserved in bacteria
DMSX03_RS09410	COG0737	Belongs to the 5'-nucleotidase family
DMSX03_RS09415	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DMSX03_RS09420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DMSX03_RS09425	COG0861	Integral membrane protein TerC family
DMSX03_RS09430	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
DMSX03_RS09440	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DMSX03_RS09445	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DMSX03_RS09450	COG2814	Major facilitator Superfamily
DMSX03_RS09455	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DMSX03_RS09460	COG2382	esterase
DMSX03_RS09465	COG1115	amino acid carrier protein
DMSX03_RS09470	COG0628	permease
DMSX03_RS09480	COG0569	domain protein
DMSX03_RS09480	COG0475	glutathione-regulated potassium exporter activity
DMSX03_RS09485	COG2239	Acts as a magnesium transporter
DMSX03_RS09490	COG0564	pseudouridine synthase activity
DMSX03_RS09495	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DMSX03_RS09500	COG2357	RelA SpoT domain protein
DMSX03_RS09515	COG2346	COG2346, Truncated hemoglobins
DMSX03_RS09520	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DMSX03_RS09525	COG1164	Oligoendopeptidase f
DMSX03_RS09535	COG4862	establishment of competence for transformation
DMSX03_RS09540	COG1393	Belongs to the ArsC family
DMSX03_RS09545	COG0180	Tryptophanyl-tRNA synthetase
DMSX03_RS09550	COG4166	transmembrane transport
DMSX03_RS09555	COG4608	Belongs to the ABC transporter superfamily
DMSX03_RS09560	COG0444	Belongs to the ABC transporter superfamily
DMSX03_RS09565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DMSX03_RS09570	COG0601	transmembrane transport
DMSX03_RS09590	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DMSX03_RS09600	COG0542	response to heat
DMSX03_RS09615	COG0561	phosphatase activity
DMSX03_RS09620	COG0446	pyridine nucleotide-disulphide oxidoreductase
DMSX03_RS09630	COG0179	Fumarylacetoacetate (FAA) hydrolase
DMSX03_RS09635	COG2311	Membrane
DMSX03_RS09640	COG1074	ATP-dependent DNA helicase activity
DMSX03_RS09645	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DMSX03_RS09660	COG0398	Pfam SNARE associated Golgi protein
DMSX03_RS09665	COG0166	Belongs to the GPI family
DMSX03_RS09670	COG0137	argininosuccinate synthase activity
DMSX03_RS09675	COG0165	Argininosuccinate lyase
DMSX03_RS09680	COG0584	glycerophosphoryl diester phosphodiesterase
DMSX03_RS09690	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DMSX03_RS09695	COG1902	pentaerythritol trinitrate reductase activity
DMSX03_RS09700	COG1098	S1 RNA binding domain
DMSX03_RS09705	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DMSX03_RS09715	COG2111	Na H antiporter
DMSX03_RS09715	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DMSX03_RS09720	COG2111	Na H antiporter
DMSX03_RS09725	COG1006	Multisubunit Na H antiporter MnhC subunit
DMSX03_RS09730	COG0651	ATP synthesis coupled electron transport
DMSX03_RS09735	COG1863	multisubunit Na H antiporter MnhE subunit
DMSX03_RS09740	COG2212	antiporter activity
DMSX03_RS09745	COG1320	monovalent cation:proton antiporter activity
DMSX03_RS09760	COG2050	protein possibly involved in aromatic compounds catabolism
DMSX03_RS09765	COG2056	Na+-H+ antiporter family
DMSX03_RS09770	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DMSX03_RS09775	COG1252	NADH dehydrogenase
DMSX03_RS09780	COG0316	Belongs to the HesB IscA family
DMSX03_RS09785	COG4844	belongs to the
DMSX03_RS09790	COG1252	NADH dehydrogenase
DMSX03_RS09795	COG4837	Protein of unknown function (DUF1462)
DMSX03_RS09800	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DMSX03_RS09805	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DMSX03_RS09810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DMSX03_RS09815	COG1696	Membrane protein involved in D-alanine export
DMSX03_RS09820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DMSX03_RS09830	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DMSX03_RS09835	COG0647	UMP catabolic process
DMSX03_RS09840	COG2445	Protein of unknown function DUF86
DMSX03_RS09850	COG4470	Protein conserved in bacteria
DMSX03_RS09855	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DMSX03_RS09860	COG0737	Belongs to the 5'-nucleotidase family
DMSX03_RS09865	COG0730	response to heat
DMSX03_RS09870	COG1801	Protein of unknown function DUF72
DMSX03_RS09875	COG2070	2-Nitropropane dioxygenase
DMSX03_RS09880	COG1253	flavin adenine dinucleotide binding
DMSX03_RS09890	COG0454	-acetyltransferase
DMSX03_RS09895	COG3223	Belongs to the PsiE family
DMSX03_RS09900	COG0719	Fe-S assembly protein
DMSX03_RS09905	COG0822	iron-sulfur transferase activity
DMSX03_RS09910	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DMSX03_RS09915	COG0719	Fe-S assembly protein
DMSX03_RS09920	COG0396	ATPase activity
DMSX03_RS09930	COG1253	flavin adenine dinucleotide binding
DMSX03_RS09940	COG1464	Belongs to the NlpA lipoprotein family
DMSX03_RS09945	COG2011	ABC-type metal ion transport system permease component
DMSX03_RS09950	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DMSX03_RS09955	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DMSX03_RS09960	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DMSX03_RS09965	COG0509	glycine decarboxylation via glycine cleavage system
DMSX03_RS09970	COG1393	Belongs to the ArsC family
DMSX03_RS09975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DMSX03_RS09980	COG0778	Nitroreductase
DMSX03_RS09985	COG0710	3-dehydroquinate dehydratase activity
DMSX03_RS09990	COG1764	response to oxidative stress
DMSX03_RS10005	COG2851	Citrate transporter
DMSX03_RS10020	COG2314	TM2 domain
DMSX03_RS10060	COG2153	protein acetylation
DMSX03_RS10065	COG0346	lactoylglutathione lyase activity
DMSX03_RS10080	COG1073	alpha beta
DMSX03_RS10110	COG0640	Transcriptional regulator
DMSX03_RS10130	COG0346	lactoylglutathione lyase activity
DMSX03_RS10160	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DMSX03_RS10165	COG0557	exoribonuclease II activity
DMSX03_RS10170	COG1647	Serine aminopeptidase, S33
DMSX03_RS10175	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DMSX03_RS10185	COG0148	phosphopyruvate hydratase activity
DMSX03_RS10190	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DMSX03_RS10195	COG0149	triose-phosphate isomerase activity
DMSX03_RS10200	COG0126	phosphoglycerate kinase activity
DMSX03_RS10225	COG1090	epimerase
DMSX03_RS10235	COG0740	serine-type endopeptidase activity
DMSX03_RS10245	COG1481	regulation of sporulation
DMSX03_RS10250	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DMSX03_RS10255	COG1660	Displays ATPase and GTPase activities
DMSX03_RS10260	COG0492	ferredoxin-NADP+ reductase activity
DMSX03_RS10270	COG0110	maltose O-acetyltransferase activity
DMSX03_RS10275	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DMSX03_RS10280	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DMSX03_RS10290	COG0556	nucleotide-excision repair
DMSX03_RS10305	COG3942	CHAP domain
DMSX03_RS10305	COG1388	LysM domain
DMSX03_RS10315	COG0653	protein targeting
DMSX03_RS10320	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DMSX03_RS10325	COG1040	competence protein
DMSX03_RS10330	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DMSX03_RS10340	COG1739	Uncharacterized protein family UPF0029
DMSX03_RS10345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DMSX03_RS10350	COG2199	diguanylate cyclase activity
DMSX03_RS10365	COG2195	Cleaves the N-terminal amino acid of tripeptides
DMSX03_RS10370	COG1929	Belongs to the glycerate kinase type-1 family
DMSX03_RS10390	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DMSX03_RS10405	COG4607	ABC-type enterochelin transport system periplasmic component
DMSX03_RS10410	COG4604	ABC transporter, ATP-binding protein
DMSX03_RS10415	COG4605	iron ion homeostasis
DMSX03_RS10420	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DMSX03_RS10425	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DMSX03_RS10430	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DMSX03_RS10435	COG1780	Probably involved in ribonucleotide reductase function
DMSX03_RS10445	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DMSX03_RS10450	COG3104	oligopeptide transport
DMSX03_RS10455	COG3104	oligopeptide transport
DMSX03_RS10460	COG1597	lipid kinase activity
DMSX03_RS10470	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DMSX03_RS10475	COG1174	glycine betaine transport
DMSX03_RS10485	COG0514	ATP-dependent DNA helicase (RecQ)
DMSX03_RS10490	COG0488	(ABC) transporter
DMSX03_RS10500	COG1368	sulfuric ester hydrolase activity
DMSX03_RS10510	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DMSX03_RS10525	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DMSX03_RS10530	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DMSX03_RS10530	COG0512	Glutamine amidotransferase of anthranilate synthase
DMSX03_RS10535	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DMSX03_RS10540	COG0720	synthase
DMSX03_RS10545	COG0602	queuosine metabolic process
DMSX03_RS10560	COG0463	Glycosyl transferase, family 2
DMSX03_RS10565	COG0656	L-ascorbic acid biosynthetic process
DMSX03_RS10570	COG1253	flavin adenine dinucleotide binding
DMSX03_RS10575	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DMSX03_RS10580	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DMSX03_RS10580	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DMSX03_RS10580	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DMSX03_RS10585	COG1105	Belongs to the carbohydrate kinase PfkB family
DMSX03_RS10590	COG1349	DNA-binding transcription factor activity
DMSX03_RS10595	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DMSX03_RS10600	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DMSX03_RS10625	COG0039	L-malate dehydrogenase activity
DMSX03_RS10630	COG0586	Pfam SNARE associated Golgi protein
DMSX03_RS10640	COG4989	oxidoreductase activity
DMSX03_RS10655	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DMSX03_RS10660	COG4988	ABC transporter
DMSX03_RS10665	COG1968	undecaprenyl-diphosphatase activity
DMSX03_RS10675	COG1671	Belongs to the UPF0178 family
DMSX03_RS10680	COG1611	Belongs to the LOG family
DMSX03_RS10685	COG1279	arginine transmembrane transporter activity
DMSX03_RS10690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DMSX03_RS10720	COG2814	Major facilitator Superfamily
DMSX03_RS10725	COG2839	Protein conserved in bacteria
DMSX03_RS10730	COG2814	Major facilitator Superfamily
DMSX03_RS10735	COG0583	DNA-binding transcription factor activity
DMSX03_RS10745	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DMSX03_RS10755	COG0217	transcriptional regulatory protein
DMSX03_RS10775	COG3942	CHAP domain
DMSX03_RS10775	COG1388	LysM domain
DMSX03_RS10780	COG0306	phosphate transporter
DMSX03_RS10785	COG1392	Phosphate transport regulator
DMSX03_RS10790	COG2205	protein histidine kinase activity
DMSX03_RS10795	COG0745	RESPONSE REGULATOR receiver
DMSX03_RS10800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DMSX03_RS10810	COG0657	acetylesterase activity
DMSX03_RS10815	COG3949	Membrane
DMSX03_RS10825	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
DMSX03_RS10830	COG1461	Dihydroxyacetone kinase
DMSX03_RS10835	COG2376	Dihydroxyacetone kinase
DMSX03_RS10840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DMSX03_RS10845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DMSX03_RS10850	COG1120	ATPase activity
DMSX03_RS10855	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DMSX03_RS10860	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DMSX03_RS10865	COG1132	(ABC) transporter
DMSX03_RS10875	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DMSX03_RS10885	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DMSX03_RS10890	COG1682	transport, permease protein
DMSX03_RS10895	COG1134	teichoic acid transport
DMSX03_RS10900	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
DMSX03_RS10920	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DMSX03_RS10925	COG0803	Belongs to the bacterial solute-binding protein 9 family
DMSX03_RS10935	COG1320	monovalent cation:proton antiporter activity
DMSX03_RS10940	COG2212	antiporter activity
DMSX03_RS10945	COG1863	multisubunit Na H antiporter MnhE subunit
DMSX03_RS10950	COG0651	ATP synthesis coupled electron transport
DMSX03_RS10955	COG1006	Multisubunit Na H antiporter MnhC subunit
DMSX03_RS10960	COG2111	Na H antiporter
DMSX03_RS10965	COG2111	Na H antiporter
DMSX03_RS10965	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DMSX03_RS11005	COG0596	Alpha beta hydrolase
DMSX03_RS11025	COG0546	phosphoglycolate phosphatase activity
DMSX03_RS11030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DMSX03_RS11035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DMSX03_RS11045	COG0018	arginyl-trna synthetase
DMSX03_RS11060	COG1078	dGTPase activity
DMSX03_RS11065	COG0456	acetyltransferase
DMSX03_RS11070	COG0655	NAD(P)H dehydrogenase (quinone) activity
DMSX03_RS11075	COG0667	Aldo Keto reductase
DMSX03_RS11080	COG4844	belongs to the
DMSX03_RS11100	COG0095	Lipoate-protein ligase
DMSX03_RS11105	COG0280	phosphate acetyltransferase
DMSX03_RS11110	COG3253	May function as heme-dependent peroxidase
DMSX03_RS11130	COG2363	Small membrane protein
DMSX03_RS11140	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DMSX03_RS11145	COG0351	phosphomethylpyrimidine kinase
DMSX03_RS11175	COG0183	Belongs to the thiolase family
DMSX03_RS11180	COG0318	PFAM AMP-dependent synthetase and ligase
DMSX03_RS11190	COG3493	citrate carrier protein
DMSX03_RS11195	COG0384	phenazine biosynthesis protein PhzF
DMSX03_RS11205	COG2329	Antibiotic biosynthesis monooxygenase
DMSX03_RS11225	COG2832	Protein of unknown function (DUF454)
DMSX03_RS11230	COG4565	transcriptional regulatory protein
DMSX03_RS11235	COG3290	protein histidine kinase activity
DMSX03_RS11240	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DMSX03_RS11245	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DMSX03_RS11250	COG0363	glucosamine-6-phosphate deaminase activity
DMSX03_RS11260	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DMSX03_RS11265	COG1469	GTP cyclohydrolase I activity
DMSX03_RS11280	COG0431	NADPH-dependent FMN reductase
DMSX03_RS11285	COG0561	phosphatase activity
DMSX03_RS11295	COG1428	Deoxynucleoside kinase
DMSX03_RS11300	COG1428	Deoxynucleoside kinase
DMSX03_RS11310	COG0546	phosphoglycolate phosphatase activity
DMSX03_RS11330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DMSX03_RS11345	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DMSX03_RS11350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DMSX03_RS11370	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
DMSX03_RS11380	COG2824	Alkylphosphonate utilization operon protein PhnA
DMSX03_RS11390	COG1113	amino acid transport
DMSX03_RS11395	COG3239	Fatty acid desaturase
DMSX03_RS11405	COG2040	homocysteine
DMSX03_RS11410	COG0833	amino acid
DMSX03_RS11420	COG0010	Belongs to the arginase family
DMSX03_RS11425	COG1914	H( )-stimulated, divalent metal cation uptake system
DMSX03_RS11440	COG1069	ribulokinase activity
DMSX03_RS11445	COG1063	alcohol dehydrogenase
DMSX03_RS11450	COG2814	Major facilitator Superfamily
DMSX03_RS11455	COG1349	DNA-binding transcription factor activity
DMSX03_RS11460	COG1132	(ABC) transporter
DMSX03_RS11465	COG1028	Short-chain dehydrogenase reductase Sdr
DMSX03_RS11470	COG1312	Catalyzes the dehydration of D-mannonate
DMSX03_RS11475	COG1904	glucuronate isomerase
DMSX03_RS11495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DMSX03_RS11510	COG0583	DNA-binding transcription factor activity
DMSX03_RS11530	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DMSX03_RS11535	COG1522	sequence-specific DNA binding
DMSX03_RS11555	COG0667	Aldo Keto reductase
DMSX03_RS11580	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DMSX03_RS11590	COG1686	Belongs to the peptidase S11 family
DMSX03_RS11605	COG1028	Short-chain dehydrogenase reductase Sdr
DMSX03_RS11610	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DMSX03_RS11615	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DMSX03_RS11655	COG1473	amidohydrolase
DMSX03_RS11660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DMSX03_RS11665	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DMSX03_RS11670	COG0049	tRNA binding
DMSX03_RS11675	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DMSX03_RS11685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DMSX03_RS11690	COG0085	RNA polymerase activity
DMSX03_RS11695	COG2813	Specifically methylates the guanine in position
DMSX03_RS11705	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DMSX03_RS11710	COG0081	regulation of translation
DMSX03_RS11715	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DMSX03_RS11720	COG0250	Participates in transcription elongation, termination and antitermination
DMSX03_RS11745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DMSX03_RS11750	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
DMSX03_RS11755	COG0215	cysteine-tRNA ligase activity
DMSX03_RS11760	COG1045	serine acetyltransferase
DMSX03_RS11765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DMSX03_RS11770	COG4956	integral membrane protein (PIN domain superfamily)
DMSX03_RS11775	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DMSX03_RS11780	COG0542	response to heat
DMSX03_RS11785	COG3869	Catalyzes the specific phosphorylation of arginine residues in
DMSX03_RS11790	COG3880	PFAM UvrB UvrC protein
DMSX03_RS11795	COG4463	regulation of RNA biosynthetic process
DMSX03_RS11805	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DMSX03_RS11810	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DMSX03_RS11815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DMSX03_RS11900	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DMSX03_RS11905	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DMSX03_RS11925	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DMSX03_RS11930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DMSX03_RS11945	COG1098	S1 RNA binding domain
DMSX03_RS11955	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DMSX03_RS11960	COG3956	TIGRFAM MazG family protein
DMSX03_RS11965	COG2244	polysaccharide biosynthetic process
DMSX03_RS11970	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DMSX03_RS11975	COG0193	aminoacyl-tRNA hydrolase activity
DMSX03_RS11980	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DMSX03_RS11985	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DMSX03_RS11990	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DMSX03_RS11995	COG2088	sporulation resulting in formation of a cellular spore
DMSX03_RS12000	COG0251	oxidation-reduction process
DMSX03_RS12005	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DMSX03_RS12010	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DMSX03_RS12015	COG4466	Protein conserved in bacteria
DMSX03_RS12020	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DMSX03_RS12025	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DMSX03_RS12030	COG0084	hydrolase, TatD family'
DMSX03_RS12035	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DMSX03_RS12035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DMSX03_RS12040	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DMSX03_RS12045	COG2827	Endonuclease containing a URI domain
DMSX03_RS12050	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DMSX03_RS12055	COG4467	Involved in initiation control of chromosome replication
DMSX03_RS12060	COG1774	PSP1 C-terminal conserved region
DMSX03_RS12065	COG0470	DNA polymerase III
DMSX03_RS12070	COG3870	Protein conserved in bacteria
DMSX03_RS12075	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DMSX03_RS12080	COG1982	Orn Lys Arg decarboxylase major
DMSX03_RS12115	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DMSX03_RS12120	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DMSX03_RS12125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DMSX03_RS12130	COG3153	acetyltransferase
DMSX03_RS12140	COG2188	Transcriptional regulator
DMSX03_RS12145	COG0366	Alpha amylase catalytic
DMSX03_RS12150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DMSX03_RS12150	COG1263	PTS System
DMSX03_RS12160	COG0493	'glutamate synthase
DMSX03_RS12165	COG0069	glutamate synthase activity
DMSX03_RS12165	COG0067	glutamate synthase
DMSX03_RS12165	COG0070	glutamate synthase
DMSX03_RS12185	COG0004	ammonium transporteR
DMSX03_RS12190	COG0494	nUDIX hydrolase
DMSX03_RS12200	COG3942	CHAP domain
DMSX03_RS12200	COG1388	LysM domain
DMSX03_RS12210	COG0129	dihydroxy-acid dehydratase activity
DMSX03_RS12225	COG0733	neurotransmitter:sodium symporter activity
DMSX03_RS12230	COG1114	Component of the transport system for branched-chain amino acids
DMSX03_RS12235	COG5646	InterPro IPR014922
DMSX03_RS12265	COG0789	Transcriptional regulator
DMSX03_RS12280	COG4195	phage-related replication protein
DMSX03_RS12285	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DMSX03_RS12290	COG2807	transmembrane transport
DMSX03_RS12305	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DMSX03_RS12310	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DMSX03_RS12315	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DMSX03_RS12320	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DMSX03_RS12325	COG3257	ureidoglycine aminohydrolase activity
DMSX03_RS12330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DMSX03_RS12340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DMSX03_RS12345	COG0406	alpha-ribazole phosphatase activity
DMSX03_RS12355	COG1595	DNA-templated transcription, initiation
DMSX03_RS12365	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DMSX03_RS12380	COG1876	peptidase activity
DMSX03_RS12385	COG0753	catalase activity
DMSX03_RS12395	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DMSX03_RS12400	COG1953	Uracil, thiamine, allantoin
DMSX03_RS12405	COG2508	Transcriptional regulator
DMSX03_RS12410	COG0456	acetyltransferase
DMSX03_RS12410	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DMSX03_RS12415	COG2814	Major facilitator Superfamily
DMSX03_RS12430	COG1301	dicarboxylic acid transport
DMSX03_RS12475	COG3591	Belongs to the peptidase S1B family
DMSX03_RS12480	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DMSX03_RS12480	COG0519	Catalyzes the synthesis of GMP from XMP
DMSX03_RS12485	COG0516	GMP reductase activity
DMSX03_RS12485	COG0517	IMP dehydrogenase activity
DMSX03_RS12490	COG2233	PERMEase
DMSX03_RS12495	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DMSX03_RS12510	COG5183	chlorophyll binding
DMSX03_RS12515	COG1823	symporter activity
DMSX03_RS12520	COG1760	l-serine dehydratase
DMSX03_RS12525	COG1760	l-serine dehydratase
DMSX03_RS12540	COG0778	Nitroreductase
DMSX03_RS12545	COG0753	catalase activity
DMSX03_RS12550	COG0450	alkyl hydroperoxide reductase
DMSX03_RS12555	COG3634	alkyl hydroperoxide reductase activity
DMSX03_RS12590	COG1280	lysine exporter protein (LysE YggA)
DMSX03_RS12595	COG2076	Multidrug Resistance protein
DMSX03_RS12600	COG2076	Multidrug Resistance protein
DMSX03_RS12620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DMSX03_RS12635	COG4195	phage-related replication protein
DMSX03_RS12640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DMSX03_RS12665	COG0583	DNA-binding transcription factor activity
DMSX03_RS12675	COG3266	domain, Protein
DMSX03_RS12675	COG5632	N-Acetylmuramoyl-L-alanine amidase
DMSX03_RS12675	COG4193	domain, Protein
DMSX03_RS12695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DMSX03_RS12700	COG2210	Belongs to the sulfur carrier protein TusA family
DMSX03_RS12705	COG1937	Protein conserved in bacteria
DMSX03_RS12710	COG0730	response to heat
DMSX03_RS12720	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DMSX03_RS12745	COG0360	Binds together with S18 to 16S ribosomal RNA
DMSX03_RS12755	COG0012	GTP binding
DMSX03_RS12760	COG4481	Protein conserved in bacteria
DMSX03_RS12765	COG0668	transmembrane transport
DMSX03_RS12770	COG5609	conserved protein (DUF2294)
DMSX03_RS12775	COG3002	Belongs to the UPF0753 family
DMSX03_RS12780	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DMSX03_RS12785	COG2207	Transcriptional regulator
DMSX03_RS12785	COG1917	Cupin 2, conserved barrel domain protein
DMSX03_RS12790	COG1486	melibiose metabolic process
DMSX03_RS12795	COG2211	Major facilitator Superfamily
DMSX03_RS12800	COG1064	alcohol dehydrogenase
DMSX03_RS12810	COG0706	membrane insertase activity
DMSX03_RS12820	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DMSX03_RS12825	COG1454	alcohol dehydrogenase
DMSX03_RS12845	COG0577	efflux transmembrane transporter activity
DMSX03_RS12850	COG1136	(ABC) transporter
DMSX03_RS12855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DMSX03_RS12860	COG1288	antiporter activity
DMSX03_RS12870	COG0789	Transcriptional regulator
DMSX03_RS12870	COG4978	Transcriptional regulator
DMSX03_RS12890	COG1012	belongs to the aldehyde dehydrogenase family
DMSX03_RS12900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DMSX03_RS12905	COG2814	Major facilitator Superfamily
DMSX03_RS12910	COG1473	amidohydrolase
DMSX03_RS12915	COG2814	Major facilitator Superfamily
DMSX03_RS12920	COG1733	regulation of RNA biosynthetic process
DMSX03_RS12925	COG2030	dehydratase
DMSX03_RS12930	COG3759	membrane
DMSX03_RS12935	COG2814	Major facilitator Superfamily
DMSX03_RS12950	COG0772	Belongs to the SEDS family
DMSX03_RS12955	COG2226	methyltransferase
DMSX03_RS12960	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DMSX03_RS12970	COG0529	Catalyzes the synthesis of activated sulfate
DMSX03_RS12975	COG2046	Belongs to the sulfate adenylyltransferase family
DMSX03_RS12980	COG0730	response to heat
DMSX03_RS13000	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DMSX03_RS13005	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DMSX03_RS13010	COG0175	sulfate reduction
DMSX03_RS13015	COG1475	DNA binding
DMSX03_RS13020	COG0626	cystathionine gamma-synthase activity
DMSX03_RS13025	COG0626	cystathionine gamma-synthase activity
DMSX03_RS13030	COG0646	methionine synthase
DMSX03_RS13030	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DMSX03_RS13035	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DMSX03_RS13045	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DMSX03_RS13070	COG0183	Belongs to the thiolase family
DMSX03_RS13080	COG1960	acyl-CoA dehydrogenase activity
DMSX03_RS13085	COG0318	PFAM AMP-dependent synthetase and ligase
DMSX03_RS13095	COG2239	Acts as a magnesium transporter
DMSX03_RS13100	COG0803	Belongs to the bacterial solute-binding protein 9 family
DMSX03_RS13105	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DMSX03_RS13125	COG0561	phosphatase activity
DMSX03_RS13130	COG0583	DNA-binding transcription factor activity
DMSX03_RS13135	COG1607	acyl-coa hydrolase
DMSX03_RS13145	COG2755	lipolytic protein G-D-S-L family
DMSX03_RS13145	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DMSX03_RS13155	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DMSX03_RS13155	COG0463	Glycosyl transferase, family 2
DMSX03_RS13160	COG0463	Glycosyl transferase, family 2
DMSX03_RS13160	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DMSX03_RS13180	COG1028	Short-chain dehydrogenase reductase Sdr
DMSX03_RS13185	COG0531	amino acid
DMSX03_RS13190	COG0656	L-ascorbic acid biosynthetic process
DMSX03_RS13195	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DMSX03_RS13220	COG0789	Transcriptional regulator
DMSX03_RS13230	COG0450	alkyl hydroperoxide reductase
DMSX03_RS13235	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DMSX03_RS13245	COG2271	Major facilitator Superfamily
DMSX03_RS13250	COG1966	Carbon starvation protein
DMSX03_RS13260	COG0357	Ribosomal RNA small subunit methyltransferase G
DMSX03_RS13265	COG0445	tRNA wobble uridine modification
DMSX03_RS13270	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DMSX03_RS13275	COG0594	ribonuclease P activity
DMSX03_RS13335	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DMSX03_RS13355	COG1136	(ABC) transporter
DMSX03_RS13410	COG1063	alcohol dehydrogenase
DMSX03_RS13425	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DMSX03_RS13440	COG1846	Transcriptional regulator
DMSX03_RS13445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DMSX03_RS13465	COG4221	oxidoreductase activity
DMSX03_RS13470	COG1595	DNA-templated transcription, initiation
DMSX03_RS13480	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DMSX03_RS13490	COG1876	peptidase activity
DMSX03_RS13500	COG1476	TRANSCRIPTIONal