locus-tag	class	description
A2I69_RS00010	COG0594	ribonuclease P activity
A2I69_RS00015	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A2I69_RS00020	COG0445	tRNA wobble uridine modification
A2I69_RS00025	COG0357	Ribosomal RNA small subunit methyltransferase G
A2I69_RS00035	COG1966	Carbon starvation protein
A2I69_RS00040	COG2271	Major facilitator Superfamily
A2I69_RS00050	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A2I69_RS00055	COG0450	alkyl hydroperoxide reductase
A2I69_RS00065	COG0789	Transcriptional regulator
A2I69_RS00075	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A2I69_RS00080	COG0656	L-ascorbic acid biosynthetic process
A2I69_RS00085	COG0531	amino acid
A2I69_RS00105	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A2I69_RS00105	COG0463	Glycosyl transferase, family 2
A2I69_RS00135	COG1607	acyl-coa hydrolase
A2I69_RS00140	COG0583	DNA-binding transcription factor activity
A2I69_RS00145	COG0561	phosphatase activity
A2I69_RS00160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A2I69_RS00190	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A2I69_RS00195	COG0803	Belongs to the bacterial solute-binding protein 9 family
A2I69_RS00200	COG2239	Acts as a magnesium transporter
A2I69_RS00210	COG0318	PFAM AMP-dependent synthetase and ligase
A2I69_RS00215	COG1960	acyl-CoA dehydrogenase activity
A2I69_RS00225	COG0183	Belongs to the thiolase family
A2I69_RS00250	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A2I69_RS00260	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A2I69_RS00265	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A2I69_RS00265	COG0646	methionine synthase
A2I69_RS00270	COG0626	cystathionine gamma-synthase activity
A2I69_RS00275	COG0626	cystathionine gamma-synthase activity
A2I69_RS00280	COG1475	DNA binding
A2I69_RS00290	COG0175	sulfate reduction
A2I69_RS00295	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A2I69_RS00300	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A2I69_RS00320	COG0730	response to heat
A2I69_RS00325	COG2046	Belongs to the sulfate adenylyltransferase family
A2I69_RS00330	COG0529	Catalyzes the synthesis of activated sulfate
A2I69_RS00345	COG2226	methyltransferase
A2I69_RS00350	COG0772	Belongs to the SEDS family
A2I69_RS00365	COG2814	Major facilitator Superfamily
A2I69_RS00370	COG3759	membrane
A2I69_RS00375	COG2030	dehydratase
A2I69_RS00380	COG1733	regulation of RNA biosynthetic process
A2I69_RS00385	COG2814	Major facilitator Superfamily
A2I69_RS00390	COG1473	amidohydrolase
A2I69_RS00395	COG2814	Major facilitator Superfamily
A2I69_RS00400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A2I69_RS00410	COG1012	belongs to the aldehyde dehydrogenase family
A2I69_RS00430	COG0789	Transcriptional regulator
A2I69_RS00430	COG4978	Transcriptional regulator
A2I69_RS00440	COG1288	antiporter activity
A2I69_RS00450	COG1136	(ABC) transporter
A2I69_RS00455	COG0577	efflux transmembrane transporter activity
A2I69_RS00470	COG2011	ABC-type metal ion transport system permease component
A2I69_RS00475	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A2I69_RS00500	COG1733	regulation of RNA biosynthetic process
A2I69_RS00525	COG1454	alcohol dehydrogenase
A2I69_RS00530	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A2I69_RS00540	COG0706	membrane insertase activity
A2I69_RS00550	COG1064	alcohol dehydrogenase
A2I69_RS00555	COG2084	Dehydrogenase
A2I69_RS00570	COG2211	Major facilitator Superfamily
A2I69_RS00575	COG1486	melibiose metabolic process
A2I69_RS00580	COG2207	Transcriptional regulator
A2I69_RS00580	COG1917	Cupin 2, conserved barrel domain protein
A2I69_RS00585	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A2I69_RS00590	COG3002	Belongs to the UPF0753 family
A2I69_RS00595	COG5609	conserved protein (DUF2294)
A2I69_RS00600	COG0668	transmembrane transport
A2I69_RS00605	COG4481	Protein conserved in bacteria
A2I69_RS00610	COG0012	GTP binding
A2I69_RS00620	COG0360	Binds together with S18 to 16S ribosomal RNA
A2I69_RS00645	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A2I69_RS00660	COG4193	domain, Protein
A2I69_RS00660	COG5632	N-Acetylmuramoyl-L-alanine amidase
A2I69_RS00660	COG3266	domain, Protein
A2I69_RS00670	COG0583	DNA-binding transcription factor activity
A2I69_RS00700	COG4195	phage-related replication protein
A2I69_RS00715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A2I69_RS00735	COG2076	Multidrug Resistance protein
A2I69_RS00740	COG2076	Multidrug Resistance protein
A2I69_RS00745	COG1280	lysine exporter protein (LysE YggA)
A2I69_RS00780	COG3634	alkyl hydroperoxide reductase activity
A2I69_RS00785	COG0450	alkyl hydroperoxide reductase
A2I69_RS00790	COG0753	catalase activity
A2I69_RS00795	COG0778	Nitroreductase
A2I69_RS00810	COG1760	l-serine dehydratase
A2I69_RS00815	COG1760	l-serine dehydratase
A2I69_RS00825	COG1823	symporter activity
A2I69_RS00830	COG5183	chlorophyll binding
A2I69_RS00845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A2I69_RS00850	COG2233	PERMEase
A2I69_RS00855	COG0516	GMP reductase activity
A2I69_RS00855	COG0517	IMP dehydrogenase activity
A2I69_RS00860	COG0519	Catalyzes the synthesis of GMP from XMP
A2I69_RS00860	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A2I69_RS00865	COG1301	dicarboxylic acid transport
A2I69_RS00885	COG2814	Major facilitator Superfamily
A2I69_RS00890	COG0583	DNA-binding transcription factor activity
A2I69_RS00895	COG2814	Major facilitator Superfamily
A2I69_RS00900	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A2I69_RS00900	COG0456	acetyltransferase
A2I69_RS00905	COG2508	Transcriptional regulator
A2I69_RS00910	COG1953	Uracil, thiamine, allantoin
A2I69_RS00915	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A2I69_RS00925	COG0753	catalase activity
A2I69_RS00930	COG1876	peptidase activity
A2I69_RS00940	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A2I69_RS00950	COG1595	DNA-templated transcription, initiation
A2I69_RS00960	COG0406	alpha-ribazole phosphatase activity
A2I69_RS00965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A2I69_RS00975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A2I69_RS00980	COG3257	ureidoglycine aminohydrolase activity
A2I69_RS00985	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A2I69_RS00990	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A2I69_RS00995	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A2I69_RS01000	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A2I69_RS01015	COG2807	transmembrane transport
A2I69_RS01020	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A2I69_RS01025	COG4195	phage-related replication protein
A2I69_RS01040	COG0789	Transcriptional regulator
A2I69_RS01065	COG2268	Band 7 protein
A2I69_RS01070	COG5646	InterPro IPR014922
A2I69_RS01075	COG1114	Component of the transport system for branched-chain amino acids
A2I69_RS01080	COG0733	neurotransmitter:sodium symporter activity
A2I69_RS01090	COG0129	dihydroxy-acid dehydratase activity
A2I69_RS01100	COG3942	CHAP domain
A2I69_RS01100	COG1388	LysM domain
A2I69_RS01110	COG0494	nUDIX hydrolase
A2I69_RS01115	COG0004	ammonium transporteR
A2I69_RS01135	COG0069	glutamate synthase activity
A2I69_RS01135	COG0070	glutamate synthase
A2I69_RS01135	COG0067	glutamate synthase
A2I69_RS01140	COG0493	'glutamate synthase
A2I69_RS01150	COG1263	PTS System
A2I69_RS01150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A2I69_RS01155	COG0366	Alpha amylase catalytic
A2I69_RS01160	COG2188	Transcriptional regulator
A2I69_RS01170	COG3153	acetyltransferase
A2I69_RS01175	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A2I69_RS01180	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A2I69_RS01185	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A2I69_RS01235	COG1982	Orn Lys Arg decarboxylase major
A2I69_RS01240	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A2I69_RS01245	COG3870	Protein conserved in bacteria
A2I69_RS01250	COG0470	DNA polymerase III
A2I69_RS01255	COG1774	PSP1 C-terminal conserved region
A2I69_RS01260	COG4467	Involved in initiation control of chromosome replication
A2I69_RS01265	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A2I69_RS01270	COG2827	Endonuclease containing a URI domain
A2I69_RS01275	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A2I69_RS01280	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A2I69_RS01280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A2I69_RS01285	COG0084	hydrolase, TatD family'
A2I69_RS01290	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A2I69_RS01295	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A2I69_RS01300	COG4466	Protein conserved in bacteria
A2I69_RS01305	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A2I69_RS01310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A2I69_RS01315	COG0251	oxidation-reduction process
A2I69_RS01320	COG2088	sporulation resulting in formation of a cellular spore
A2I69_RS01325	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A2I69_RS01330	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A2I69_RS01335	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A2I69_RS01340	COG0193	aminoacyl-tRNA hydrolase activity
A2I69_RS01345	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A2I69_RS01350	COG2244	polysaccharide biosynthetic process
A2I69_RS01355	COG3956	TIGRFAM MazG family protein
A2I69_RS01360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A2I69_RS01370	COG1098	S1 RNA binding domain
A2I69_RS01385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A2I69_RS01390	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A2I69_RS01410	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A2I69_RS01415	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A2I69_RS01500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A2I69_RS01505	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
A2I69_RS01510	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
A2I69_RS01515	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A2I69_RS01520	COG4463	regulation of RNA biosynthetic process
A2I69_RS01525	COG3880	PFAM UvrB UvrC protein
A2I69_RS01530	COG3869	Catalyzes the specific phosphorylation of arginine residues in
A2I69_RS01535	COG0542	response to heat
A2I69_RS01540	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A2I69_RS01545	COG4956	integral membrane protein (PIN domain superfamily)
A2I69_RS01550	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A2I69_RS01555	COG1045	serine acetyltransferase
A2I69_RS01560	COG0215	cysteine-tRNA ligase activity
A2I69_RS01565	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
A2I69_RS01570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A2I69_RS01595	COG0250	Participates in transcription elongation, termination and antitermination
A2I69_RS01600	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A2I69_RS01605	COG0081	regulation of translation
A2I69_RS01610	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A2I69_RS01615	COG0222	ribosome binding
A2I69_RS01620	COG2813	Specifically methylates the guanine in position
A2I69_RS01625	COG0085	RNA polymerase activity
A2I69_RS01630	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A2I69_RS01640	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A2I69_RS01645	COG0049	tRNA binding
A2I69_RS01650	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A2I69_RS01655	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A2I69_RS01660	COG1473	amidohydrolase
A2I69_RS01705	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A2I69_RS01710	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A2I69_RS01715	COG1028	Short-chain dehydrogenase reductase Sdr
A2I69_RS01730	COG1686	Belongs to the peptidase S11 family
A2I69_RS01750	COG0463	Glycosyl transferase, family 2
A2I69_RS01755	COG1215	transferase activity, transferring glycosyl groups
A2I69_RS01755	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A2I69_RS01760	COG1215	transferase activity, transferring glycosyl groups
A2I69_RS01760	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A2I69_RS01785	COG0583	DNA-binding transcription factor activity
A2I69_RS01800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A2I69_RS01820	COG1904	glucuronate isomerase
A2I69_RS01825	COG1312	Catalyzes the dehydration of D-mannonate
A2I69_RS01830	COG1028	Short-chain dehydrogenase reductase Sdr
A2I69_RS01835	COG1132	(ABC) transporter
A2I69_RS01840	COG1349	DNA-binding transcription factor activity
A2I69_RS01845	COG2814	Major facilitator Superfamily
A2I69_RS01850	COG1063	alcohol dehydrogenase
A2I69_RS01855	COG1069	ribulokinase activity
A2I69_RS01870	COG1914	H( )-stimulated, divalent metal cation uptake system
A2I69_RS01885	COG0833	amino acid
A2I69_RS01890	COG2040	homocysteine
A2I69_RS01900	COG3239	Fatty acid desaturase
A2I69_RS01905	COG1113	amino acid transport
A2I69_RS01915	COG2824	Alkylphosphonate utilization operon protein PhnA
A2I69_RS01925	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A2I69_RS01945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A2I69_RS01950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A2I69_RS01955	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A2I69_RS01970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A2I69_RS01990	COG0546	phosphoglycolate phosphatase activity
A2I69_RS02000	COG1428	Deoxynucleoside kinase
A2I69_RS02005	COG1428	Deoxynucleoside kinase
A2I69_RS02015	COG0561	phosphatase activity
A2I69_RS02020	COG0431	NADPH-dependent FMN reductase
A2I69_RS02035	COG1469	GTP cyclohydrolase I activity
A2I69_RS02040	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A2I69_RS02050	COG0363	glucosamine-6-phosphate deaminase activity
A2I69_RS02055	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A2I69_RS02060	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A2I69_RS02065	COG3290	protein histidine kinase activity
A2I69_RS02070	COG4565	transcriptional regulatory protein
A2I69_RS02075	COG2832	Protein of unknown function (DUF454)
A2I69_RS02110	COG2329	Antibiotic biosynthesis monooxygenase
A2I69_RS02115	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A2I69_RS02130	COG0697	spore germination
A2I69_RS02145	COG0384	phenazine biosynthesis protein PhzF
A2I69_RS02150	COG3493	citrate carrier protein
A2I69_RS02160	COG0318	PFAM AMP-dependent synthetase and ligase
A2I69_RS02165	COG0183	Belongs to the thiolase family
A2I69_RS02195	COG0351	phosphomethylpyrimidine kinase
A2I69_RS02200	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A2I69_RS02210	COG2363	Small membrane protein
A2I69_RS02230	COG3253	May function as heme-dependent peroxidase
A2I69_RS02235	COG0280	phosphate acetyltransferase
A2I69_RS02240	COG0095	Lipoate-protein ligase
A2I69_RS02260	COG1263	PTS System
A2I69_RS02260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A2I69_RS02265	COG1737	Transcriptional regulator
A2I69_RS02270	COG0673	inositol 2-dehydrogenase activity
A2I69_RS02280	COG0673	inositol 2-dehydrogenase activity
A2I69_RS02285	COG1082	Xylose isomerase domain protein TIM barrel
A2I69_RS02290	COG4844	belongs to the
A2I69_RS02295	COG0667	Aldo Keto reductase
A2I69_RS02300	COG0655	NAD(P)H dehydrogenase (quinone) activity
A2I69_RS02305	COG0456	acetyltransferase
A2I69_RS02310	COG1078	dGTPase activity
A2I69_RS02325	COG0018	arginyl-trna synthetase
A2I69_RS02335	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A2I69_RS02340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A2I69_RS02365	COG2267	carboxylic ester hydrolase activity
A2I69_RS02405	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A2I69_RS02405	COG2111	Na H antiporter
A2I69_RS02410	COG2111	Na H antiporter
A2I69_RS02415	COG1006	Multisubunit Na H antiporter MnhC subunit
A2I69_RS02420	COG0651	ATP synthesis coupled electron transport
A2I69_RS02425	COG1863	multisubunit Na H antiporter MnhE subunit
A2I69_RS02430	COG2212	antiporter activity
A2I69_RS02435	COG1320	monovalent cation:proton antiporter activity
A2I69_RS02445	COG0803	Belongs to the bacterial solute-binding protein 9 family
A2I69_RS02450	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A2I69_RS02470	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A2I69_RS02475	COG1134	teichoic acid transport
A2I69_RS02480	COG1682	transport, permease protein
A2I69_RS02485	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A2I69_RS02495	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A2I69_RS02505	COG1132	(ABC) transporter
A2I69_RS02510	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A2I69_RS02515	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A2I69_RS02520	COG1120	ATPase activity
A2I69_RS02525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A2I69_RS02530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A2I69_RS02535	COG2376	Dihydroxyacetone kinase
A2I69_RS02540	COG1461	Dihydroxyacetone kinase
A2I69_RS02545	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
A2I69_RS02555	COG3949	Membrane
A2I69_RS02560	COG0657	acetylesterase activity
A2I69_RS02570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A2I69_RS02575	COG0745	RESPONSE REGULATOR receiver
A2I69_RS02580	COG2205	protein histidine kinase activity
A2I69_RS02585	COG1392	Phosphate transport regulator
A2I69_RS02590	COG0306	phosphate transporter
A2I69_RS02595	COG1388	LysM domain
A2I69_RS02595	COG3942	CHAP domain
A2I69_RS02615	COG0217	transcriptional regulatory protein
A2I69_RS02625	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A2I69_RS02635	COG0583	DNA-binding transcription factor activity
A2I69_RS02640	COG2814	Major facilitator Superfamily
A2I69_RS02645	COG2839	Protein conserved in bacteria
A2I69_RS02650	COG2814	Major facilitator Superfamily
A2I69_RS02680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A2I69_RS02685	COG1279	arginine transmembrane transporter activity
A2I69_RS02690	COG1611	Belongs to the LOG family
A2I69_RS02695	COG1671	Belongs to the UPF0178 family
A2I69_RS02705	COG1968	undecaprenyl-diphosphatase activity
A2I69_RS02710	COG4988	ABC transporter
A2I69_RS02715	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A2I69_RS02730	COG4989	oxidoreductase activity
A2I69_RS02740	COG0586	Pfam SNARE associated Golgi protein
A2I69_RS02745	COG0039	L-malate dehydrogenase activity
A2I69_RS02775	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A2I69_RS02780	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A2I69_RS02785	COG1349	DNA-binding transcription factor activity
A2I69_RS02790	COG1105	Belongs to the carbohydrate kinase PfkB family
A2I69_RS02795	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A2I69_RS02795	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A2I69_RS02795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A2I69_RS02800	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A2I69_RS02805	COG1253	flavin adenine dinucleotide binding
A2I69_RS02810	COG0656	L-ascorbic acid biosynthetic process
A2I69_RS02815	COG0463	Glycosyl transferase, family 2
A2I69_RS02830	COG0602	queuosine metabolic process
A2I69_RS02835	COG0720	synthase
A2I69_RS02840	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A2I69_RS02845	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A2I69_RS02845	COG0512	Glutamine amidotransferase of anthranilate synthase
A2I69_RS02865	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A2I69_RS02875	COG1368	sulfuric ester hydrolase activity
A2I69_RS02885	COG0488	(ABC) transporter
A2I69_RS02890	COG0514	ATP-dependent DNA helicase (RecQ)
A2I69_RS02900	COG1174	glycine betaine transport
A2I69_RS02905	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A2I69_RS02915	COG1597	lipid kinase activity
A2I69_RS02920	COG3104	oligopeptide transport
A2I69_RS02925	COG3104	oligopeptide transport
A2I69_RS02930	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A2I69_RS02940	COG1780	Probably involved in ribonucleotide reductase function
A2I69_RS02945	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A2I69_RS02950	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A2I69_RS02955	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A2I69_RS02960	COG4605	iron ion homeostasis
A2I69_RS02965	COG4604	ABC transporter, ATP-binding protein
A2I69_RS02970	COG4607	ABC-type enterochelin transport system periplasmic component
A2I69_RS02985	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A2I69_RS03005	COG1929	Belongs to the glycerate kinase type-1 family
A2I69_RS03010	COG2195	Cleaves the N-terminal amino acid of tripeptides
A2I69_RS03025	COG2199	diguanylate cyclase activity
A2I69_RS03030	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A2I69_RS03035	COG1739	Uncharacterized protein family UPF0029
A2I69_RS03045	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A2I69_RS03050	COG1040	competence protein
A2I69_RS03055	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A2I69_RS03060	COG0653	protein targeting
A2I69_RS03070	COG3942	CHAP domain
A2I69_RS03070	COG1388	LysM domain
A2I69_RS03085	COG0556	nucleotide-excision repair
A2I69_RS03095	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A2I69_RS03100	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A2I69_RS03105	COG0110	maltose O-acetyltransferase activity
A2I69_RS03115	COG0492	ferredoxin-NADP+ reductase activity
A2I69_RS03120	COG1660	Displays ATPase and GTPase activities
A2I69_RS03125	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A2I69_RS03130	COG1481	regulation of sporulation
A2I69_RS03140	COG0740	serine-type endopeptidase activity
A2I69_RS03150	COG1090	epimerase
A2I69_RS03185	COG0126	phosphoglycerate kinase activity
A2I69_RS03190	COG0149	triose-phosphate isomerase activity
A2I69_RS03195	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A2I69_RS03200	COG0148	phosphopyruvate hydratase activity
A2I69_RS03210	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A2I69_RS03215	COG1647	Serine aminopeptidase, S33
A2I69_RS03220	COG0557	exoribonuclease II activity
A2I69_RS03225	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A2I69_RS03255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A2I69_RS03305	COG1073	alpha beta
A2I69_RS03320	COG0346	lactoylglutathione lyase activity
A2I69_RS03325	COG2153	protein acetylation
A2I69_RS03365	COG2314	TM2 domain
A2I69_RS03380	COG2851	Citrate transporter
A2I69_RS03395	COG1764	response to oxidative stress
A2I69_RS03400	COG0710	3-dehydroquinate dehydratase activity
A2I69_RS03405	COG0778	Nitroreductase
A2I69_RS03410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A2I69_RS03415	COG1393	Belongs to the ArsC family
A2I69_RS03420	COG0509	glycine decarboxylation via glycine cleavage system
A2I69_RS03425	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A2I69_RS03430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A2I69_RS03435	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A2I69_RS03440	COG2011	ABC-type metal ion transport system permease component
A2I69_RS03445	COG1464	Belongs to the NlpA lipoprotein family
A2I69_RS03455	COG1253	flavin adenine dinucleotide binding
A2I69_RS03465	COG0396	ATPase activity
A2I69_RS03470	COG0719	Fe-S assembly protein
A2I69_RS03475	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A2I69_RS03480	COG0822	iron-sulfur transferase activity
A2I69_RS03485	COG0719	Fe-S assembly protein
A2I69_RS03490	COG0454	-acetyltransferase
A2I69_RS03500	COG1253	flavin adenine dinucleotide binding
A2I69_RS03505	COG2070	2-Nitropropane dioxygenase
A2I69_RS03510	COG1801	Protein of unknown function DUF72
A2I69_RS03515	COG0730	response to heat
A2I69_RS03520	COG0737	Belongs to the 5'-nucleotidase family
A2I69_RS03525	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A2I69_RS03530	COG4470	Protein conserved in bacteria
A2I69_RS03540	COG2445	Protein of unknown function DUF86
A2I69_RS03545	COG0647	UMP catabolic process
A2I69_RS03550	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A2I69_RS03560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A2I69_RS03565	COG1696	Membrane protein involved in D-alanine export
A2I69_RS03570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A2I69_RS03575	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A2I69_RS03580	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A2I69_RS03585	COG4837	Protein of unknown function (DUF1462)
A2I69_RS03590	COG1252	NADH dehydrogenase
A2I69_RS03595	COG4844	belongs to the
A2I69_RS03600	COG0316	Belongs to the HesB IscA family
A2I69_RS03605	COG1252	NADH dehydrogenase
A2I69_RS03610	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A2I69_RS03615	COG2056	Na+-H+ antiporter family
A2I69_RS03620	COG2050	protein possibly involved in aromatic compounds catabolism
A2I69_RS03630	COG1320	monovalent cation:proton antiporter activity
A2I69_RS03635	COG2212	antiporter activity
A2I69_RS03640	COG1863	multisubunit Na H antiporter MnhE subunit
A2I69_RS03645	COG0651	ATP synthesis coupled electron transport
A2I69_RS03650	COG1006	Multisubunit Na H antiporter MnhC subunit
A2I69_RS03655	COG2111	Na H antiporter
A2I69_RS03660	COG2111	Na H antiporter
A2I69_RS03660	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A2I69_RS03670	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A2I69_RS03675	COG1098	S1 RNA binding domain
A2I69_RS03685	COG1902	pentaerythritol trinitrate reductase activity
A2I69_RS03690	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A2I69_RS03700	COG0584	glycerophosphoryl diester phosphodiesterase
A2I69_RS03705	COG0165	Argininosuccinate lyase
A2I69_RS03710	COG0137	argininosuccinate synthase activity
A2I69_RS03715	COG0166	Belongs to the GPI family
A2I69_RS03720	COG0398	Pfam SNARE associated Golgi protein
A2I69_RS03735	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A2I69_RS03740	COG1074	ATP-dependent DNA helicase activity
A2I69_RS03745	COG2311	Membrane
A2I69_RS03750	COG0179	Fumarylacetoacetate (FAA) hydrolase
A2I69_RS03760	COG0446	pyridine nucleotide-disulphide oxidoreductase
A2I69_RS03765	COG0561	phosphatase activity
A2I69_RS03790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A2I69_RS03810	COG0601	transmembrane transport
A2I69_RS03815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A2I69_RS03820	COG0444	Belongs to the ABC transporter superfamily
A2I69_RS03825	COG4608	Belongs to the ABC transporter superfamily
A2I69_RS03830	COG4166	transmembrane transport
A2I69_RS03835	COG0180	Tryptophanyl-tRNA synthetase
A2I69_RS03840	COG1393	Belongs to the ArsC family
A2I69_RS03845	COG4862	establishment of competence for transformation
A2I69_RS03855	COG1164	Oligoendopeptidase f
A2I69_RS03860	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A2I69_RS03865	COG2346	COG2346, Truncated hemoglobins
A2I69_RS03880	COG2357	RelA SpoT domain protein
A2I69_RS03885	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A2I69_RS03890	COG0564	pseudouridine synthase activity
A2I69_RS03895	COG2239	Acts as a magnesium transporter
A2I69_RS03900	COG0475	glutathione-regulated potassium exporter activity
A2I69_RS03900	COG0569	domain protein
A2I69_RS03910	COG0628	permease
A2I69_RS03915	COG1115	amino acid carrier protein
A2I69_RS03920	COG2382	esterase
A2I69_RS03925	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A2I69_RS03930	COG2814	Major facilitator Superfamily
A2I69_RS03935	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A2I69_RS03940	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A2I69_RS03950	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A2I69_RS03955	COG0861	Integral membrane protein TerC family
A2I69_RS03960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A2I69_RS03965	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A2I69_RS03970	COG0737	Belongs to the 5'-nucleotidase family
A2I69_RS03980	COG4873	Protein conserved in bacteria
A2I69_RS03995	COG4903	ComK protein
A2I69_RS04065	COG2314	TM2 domain
A2I69_RS04075	COG1575	Belongs to the MenA family. Type 1 subfamily
A2I69_RS04080	COG1169	isochorismate synthase
A2I69_RS04085	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A2I69_RS04090	COG2267	carboxylic ester hydrolase activity
A2I69_RS04095	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A2I69_RS04100	COG1846	Transcriptional regulator
A2I69_RS04105	COG0436	Aminotransferase
A2I69_RS04110	COG3594	Acyltransferase
A2I69_RS04135	COG1316	TRANSCRIPTIONal
A2I69_RS04140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A2I69_RS04155	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A2I69_RS04160	COG1845	cytochrome c oxidase, subunit III
A2I69_RS04165	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A2I69_RS04170	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A2I69_RS04180	COG1017	nitric oxide dioxygenase activity
A2I69_RS04180	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A2I69_RS04185	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A2I69_RS04190	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A2I69_RS04195	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A2I69_RS04200	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A2I69_RS04205	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A2I69_RS04210	COG0047	phosphoribosylformylglycinamidine synthase activity
A2I69_RS04215	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A2I69_RS04225	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A2I69_RS04235	COG0138	bifunctional purine biosynthesis protein purh
A2I69_RS04240	COG0151	Belongs to the GarS family
A2I69_RS04250	COG4172	Belongs to the ABC transporter superfamily
A2I69_RS04270	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A2I69_RS04280	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A2I69_RS04285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A2I69_RS04295	COG1271	oxidase subunit
A2I69_RS04300	COG1294	oxidase, subunit
A2I69_RS04305	COG0569	domain protein
A2I69_RS04310	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A2I69_RS04315	COG5503	Protein of unknown function (DUF1447)
A2I69_RS04325	COG0242	peptide deformylase activity
A2I69_RS04355	COG4476	Belongs to the UPF0223 family
A2I69_RS04365	COG3842	ATPase activity
A2I69_RS04370	COG1176	ABC-type spermidine putrescine transport system, permease component I
A2I69_RS04375	COG1177	transmembrane transport
A2I69_RS04390	COG1914	H( )-stimulated, divalent metal cation uptake system
A2I69_RS04400	COG4493	Belongs to the UPF0637 family
A2I69_RS04405	COG0483	inositol monophosphate 1-phosphatase activity
A2I69_RS04415	COG1217	gtp-binding protein TYPA
A2I69_RS04420	COG4896	Protein conserved in bacteria
A2I69_RS04425	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A2I69_RS04430	COG4838	Belongs to the UPF0358 family
A2I69_RS04445	COG1612	heme a metabolic process
A2I69_RS04450	COG0109	protoheme IX farnesyltransferase activity
A2I69_RS04470	COG3679	Belongs to the UPF0342 family
A2I69_RS04475	COG0584	glycerophosphoryl diester phosphodiesterase
A2I69_RS04480	COG4471	UPF0298 protein
A2I69_RS04490	COG0742	ribosomal rna small subunit methyltransferase
A2I69_RS04495	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A2I69_RS04500	COG1323	Belongs to the UPF0348 family
A2I69_RS04510	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A2I69_RS04520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A2I69_RS04525	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A2I69_RS04530	COG0072	phenylalanine-tRNA ligase activity
A2I69_RS04535	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A2I69_RS04540	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
A2I69_RS04550	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A2I69_RS04550	COG1796	DNA polymerase
A2I69_RS04555	COG1193	negative regulation of DNA recombination
A2I69_RS04560	COG3118	belongs to the thioredoxin family
A2I69_RS04565	COG0322	excinuclease ABC activity
A2I69_RS04570	COG2009	succinate dehydrogenase
A2I69_RS04575	COG1053	succinate dehydrogenase
A2I69_RS04580	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A2I69_RS04585	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A2I69_RS04590	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A2I69_RS04640	COG1011	Hydrolase
A2I69_RS04645	COG0454	-acetyltransferase
A2I69_RS04650	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
A2I69_RS04655	COG2001	Belongs to the MraZ family
A2I69_RS04660	COG0275	rRNA processing
A2I69_RS04665	COG4839	cell division protein FtsL
A2I69_RS04670	COG0768	penicillin binding
A2I69_RS04675	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A2I69_RS04680	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A2I69_RS04690	COG0849	cell division
A2I69_RS04695	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A2I69_RS04700	COG1496	oxidoreductase activity
A2I69_RS04705	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A2I69_RS04710	COG1799	cell septum assembly
A2I69_RS04715	COG0762	integral membrane protein
A2I69_RS04725	COG3599	regulation of cell shape
A2I69_RS04730	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A2I69_RS04740	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A2I69_RS04745	COG0564	pseudouridine synthase activity
A2I69_RS04750	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A2I69_RS04760	COG0540	Belongs to the ATCase OTCase family
A2I69_RS04770	COG0505	Belongs to the CarA family
A2I69_RS04775	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A2I69_RS04780	COG0284	orotidine-5'-phosphate decarboxylase activity
A2I69_RS04785	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A2I69_RS04795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A2I69_RS04805	COG1293	RNA-binding protein homologous to eukaryotic snRNP
A2I69_RS04810	COG0194	GDP metabolic process
A2I69_RS04815	COG1758	RNA polymerase activity
A2I69_RS04820	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A2I69_RS04825	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A2I69_RS04840	COG0242	peptide deformylase activity
A2I69_RS04845	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A2I69_RS04850	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A2I69_RS04850	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A2I69_RS04855	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A2I69_RS04870	COG1162	GTPase activity
A2I69_RS04875	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A2I69_RS04880	COG1564	THIamine pyrophosphokinase
A2I69_RS04885	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A2I69_RS04890	COG1302	Protein conserved in bacteria
A2I69_RS04895	COG1461	Dihydroxyacetone kinase
A2I69_RS04900	COG1760	l-serine dehydratase
A2I69_RS04905	COG1760	l-serine dehydratase
A2I69_RS04910	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A2I69_RS04920	COG1349	DNA-binding transcription factor activity
A2I69_RS04925	COG0416	fatty acid biosynthetic process
A2I69_RS04940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A2I69_RS04945	COG0571	ribonuclease III activity
A2I69_RS04950	COG1196	nuclear chromosome segregation
A2I69_RS04955	COG0552	protein localization to endoplasmic reticulum
A2I69_RS04960	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
A2I69_RS04965	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A2I69_RS04970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A2I69_RS04975	COG1028	Short-chain dehydrogenase reductase Sdr
A2I69_RS04980	COG0228	four-way junction DNA binding
A2I69_RS04985	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A2I69_RS04990	COG0336	Belongs to the RNA methyltransferase TrmD family
A2I69_RS04995	COG0335	large ribosomal subunit rRNA binding
A2I69_RS05005	COG4485	Bacterial membrane protein, YfhO
A2I69_RS05015	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A2I69_RS05020	COG0045	succinate-CoA ligase (ADP-forming) activity
A2I69_RS05030	COG0758	DNA mediated transformation
A2I69_RS05035	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A2I69_RS05040	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A2I69_RS05045	COG4974	Belongs to the 'phage' integrase family
A2I69_RS05050	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A2I69_RS05055	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A2I69_RS05060	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A2I69_RS05065	COG0052	Belongs to the universal ribosomal protein uS2 family
A2I69_RS05070	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A2I69_RS05075	COG0528	UMP kinase activity
A2I69_RS05080	COG0233	cytoplasmic translational termination
A2I69_RS05085	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A2I69_RS05090	COG4589	Belongs to the CDS family
A2I69_RS05100	COG0442	prolyl-tRNA aminoacylation
A2I69_RS05105	COG2176	DNA-directed DNA polymerase activity
A2I69_RS05110	COG0779	Required for maturation of 30S ribosomal subunits
A2I69_RS05115	COG0195	Participates in both transcription termination and antitermination
A2I69_RS05120	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A2I69_RS05125	COG1358	cellular component organization or biogenesis
A2I69_RS05145	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A2I69_RS05150	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A2I69_RS05155	COG0196	riboflavin kinase activity
A2I69_RS05160	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A2I69_RS05165	COG1185	polyribonucleotide nucleotidyltransferase activity
A2I69_RS05170	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A2I69_RS05175	COG1674	ftsk spoiiie
A2I69_RS05180	COG2188	Transcriptional regulator
A2I69_RS05185	COG0612	Peptidase, M16
A2I69_RS05190	COG0612	Peptidase, M16
A2I69_RS05195	COG0300	oxidoreductase activity
A2I69_RS05215	COG1546	Belongs to the CinA family
A2I69_RS05215	COG1058	Belongs to the CinA family
A2I69_RS05220	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A2I69_RS05225	COG1418	mRNA catabolic process
A2I69_RS05235	COG1692	metallophosphoesterase
A2I69_RS05240	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A2I69_RS05240	COG0674	pyruvate-flavodoxin oxidoreductase activity
A2I69_RS05245	COG1013	pyruvate-flavodoxin oxidoreductase activity
A2I69_RS05255	COG4195	phage-related replication protein
A2I69_RS05260	COG1959	2 iron, 2 sulfur cluster binding
A2I69_RS05275	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A2I69_RS05280	COG4550	Control of competence regulator ComK, YlbF/YmcA
A2I69_RS05290	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A2I69_RS05295	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A2I69_RS05305	COG1619	proteins homologs of microcin C7 resistance protein MccF
A2I69_RS05310	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A2I69_RS05315	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A2I69_RS05320	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A2I69_RS05330	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A2I69_RS05335	COG1923	regulation of RNA biosynthetic process
A2I69_RS05340	COG0386	Belongs to the glutathione peroxidase family
A2I69_RS05345	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A2I69_RS05350	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
A2I69_RS05355	COG0789	Transcriptional regulator
A2I69_RS05365	COG1764	response to oxidative stress
A2I69_RS05370	COG2808	Putative FMN-binding domain
A2I69_RS05380	COG1131	(ABC) transporter
A2I69_RS05385	COG0842	Transport permease protein
A2I69_RS05390	COG4585	Histidine kinase
A2I69_RS05395	COG2197	response regulator
A2I69_RS05425	COG0527	aspartate kinase activity
A2I69_RS05430	COG0460	homoserine dehydrogenase
A2I69_RS05435	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A2I69_RS05440	COG0083	homoserine kinase activity
A2I69_RS05445	COG0561	phosphatase activity
A2I69_RS05455	COG0833	amino acid
A2I69_RS05460	COG0753	catalase activity
A2I69_RS05465	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A2I69_RS05470	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A2I69_RS05475	COG0516	GMP reductase activity
A2I69_RS05485	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A2I69_RS05505	COG3763	UPF0154 protein
A2I69_RS05515	COG4846	Membrane protein involved in cytochrome C biogenesis
A2I69_RS05520	COG0420	3'-5' exonuclease activity
A2I69_RS05525	COG0419	ATPase involved in DNA repair
A2I69_RS05530	COG1970	mechanosensitive ion channel activity
A2I69_RS05535	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A2I69_RS05540	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A2I69_RS05545	COG0824	Thioesterase
A2I69_RS05550	COG4841	protein insertion into membrane
A2I69_RS05555	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A2I69_RS05565	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A2I69_RS05570	COG1115	amino acid carrier protein
A2I69_RS05575	COG3711	transcriptional antiterminator
A2I69_RS05585	COG0628	permease
A2I69_RS05590	COG0392	lysyltransferase activity
A2I69_RS05590	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A2I69_RS05600	COG1609	Transcriptional regulator
A2I69_RS05605	COG1869	D-ribose catabolic process
A2I69_RS05610	COG1129	ABC transporter
A2I69_RS05615	COG1172	Belongs to the binding-protein-dependent transport system permease family
A2I69_RS05620	COG1879	ABC-type sugar transport system periplasmic component
A2I69_RS05635	COG1942	4-Oxalocrotonate Tautomerase
A2I69_RS05640	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A2I69_RS05645	COG0287	Prephenate dehydrogenase
A2I69_RS05655	COG1363	Peptidase, m42
A2I69_RS05685	COG4555	ABC transporter
A2I69_RS05745	COG1280	lysine exporter protein (LysE YggA)
A2I69_RS05750	COG0438	transferase activity, transferring glycosyl groups
A2I69_RS05755	COG0456	acetyltransferase
A2I69_RS05760	COG0640	Transcriptional regulator
A2I69_RS05780	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A2I69_RS05785	COG0512	Glutamine amidotransferase of anthranilate synthase
A2I69_RS05790	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A2I69_RS05795	COG0134	indole-3-glycerol-phosphate synthase activity
A2I69_RS05805	COG0133	tryptophan synthase activity
A2I69_RS05810	COG0159	tryptophan synthase activity
A2I69_RS05820	COG2348	transferase activity, transferring amino-acyl groups
A2I69_RS05835	COG4607	ABC-type enterochelin transport system periplasmic component
A2I69_RS05845	COG1164	Oligoendopeptidase f
A2I69_RS05855	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A2I69_RS05860	COG0581	inorganic phosphate transmembrane transporter activity
A2I69_RS05865	COG0573	inorganic phosphate transmembrane transporter activity
A2I69_RS05870	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A2I69_RS05875	COG2996	Protein conserved in bacteria
A2I69_RS05880	COG0488	(ABC) transporter
A2I69_RS05890	COG0527	aspartate kinase activity
A2I69_RS05895	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A2I69_RS05900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A2I69_RS05905	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A2I69_RS05915	COG1473	amidohydrolase
A2I69_RS05930	COG1278	Cold shock
A2I69_RS05940	COG1254	Belongs to the acylphosphatase family
A2I69_RS05950	COG3853	Toxic anion resistance protein (TelA)
A2I69_RS05955	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A2I69_RS05960	COG1114	Component of the transport system for branched-chain amino acids
A2I69_RS05965	COG4548	von Willebrand factor, type A
A2I69_RS05970	COG0714	Associated with various cellular activities
A2I69_RS05995	COG1121	(ABC) transporter
A2I69_RS06000	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A2I69_RS06025	COG2207	Transcriptional regulator
A2I69_RS06025	COG1917	Cupin 2, conserved barrel domain protein
A2I69_RS06035	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A2I69_RS06045	COG0508	dehydrogenase complex catalyzes the overall conversion of
A2I69_RS06050	COG0567	Dehydrogenase, E1 component
A2I69_RS06055	COG5002	protein histidine kinase activity
A2I69_RS06060	COG0745	RESPONSE REGULATOR receiver
A2I69_RS06065	COG0671	phosphoesterase, PA-phosphatase related
A2I69_RS06070	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A2I69_RS06080	COG0793	Belongs to the peptidase S41A family
A2I69_RS06085	COG4479	Belongs to the UPF0346 family
A2I69_RS06095	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A2I69_RS06115	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A2I69_RS06125	COG1413	lyase activity
A2I69_RS06130	COG1413	lyase activity
A2I69_RS06140	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A2I69_RS06145	COG3545	Serine hydrolase
A2I69_RS06155	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A2I69_RS06160	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A2I69_RS06170	COG2962	Rard protein
A2I69_RS06175	COG0116	Belongs to the methyltransferase superfamily
A2I69_RS06190	COG4474	Belongs to the UPF0398 family
A2I69_RS06200	COG3331	DNA recombination
A2I69_RS06205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A2I69_RS06205	COG4499	WXG100 protein secretion system (Wss), protein YukC
A2I69_RS06215	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A2I69_RS06220	COG3935	DnaD domain protein
A2I69_RS06225	COG0017	Asparaginyl-tRNA synthetase
A2I69_RS06230	COG1199	ATP-dependent helicase activity
A2I69_RS06230	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A2I69_RS06240	COG0617	tRNA 3'-terminal CCA addition
A2I69_RS06245	COG0438	transferase activity, transferring glycosyl groups
A2I69_RS06250	COG1694	Mazg nucleotide pyrophosphohydrolase
A2I69_RS06255	COG2738	Putative neutral zinc metallopeptidase
A2I69_RS06260	COG4347	Protein of unknown function (DUF1405)
A2I69_RS06265	COG5582	Belongs to the UPF0302 family
A2I69_RS06275	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A2I69_RS06280	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A2I69_RS06285	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A2I69_RS06290	COG0105	UTP biosynthetic process
A2I69_RS06295	COG0142	geranyltranstransferase activity
A2I69_RS06300	COG2226	methyltransferase
A2I69_RS06315	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A2I69_RS06320	COG1160	GTP binding
A2I69_RS06325	COG0539	negative regulation of cytoplasmic translation
A2I69_RS06330	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A2I69_RS06340	COG0492	ferredoxin-NADP+ reductase activity
A2I69_RS06345	COG1388	LysM domain
A2I69_RS06350	COG0514	ATP-dependent DNA helicase (RecQ)
A2I69_RS06360	COG1141	Ferredoxin
A2I69_RS06375	COG0745	RESPONSE REGULATOR receiver
A2I69_RS06380	COG1187	pseudouridine synthase activity
A2I69_RS06385	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A2I69_RS06390	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A2I69_RS06400	COG4974	Belongs to the 'phage' integrase family
A2I69_RS06405	COG0735	belongs to the Fur family
A2I69_RS06410	COG0494	nUDIX hydrolase
A2I69_RS06415	COG0667	Aldo Keto reductase
A2I69_RS06425	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A2I69_RS06430	COG1234	tRNA 3'-trailer cleavage
A2I69_RS06435	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A2I69_RS06445	COG0366	Alpha amylase catalytic
A2I69_RS06450	COG1609	Transcriptional regulator
A2I69_RS06460	COG2195	Cleaves the N-terminal amino acid of tripeptides
A2I69_RS06470	COG4129	membrane
A2I69_RS06490	COG0508	dehydrogenase complex catalyzes the overall conversion of
A2I69_RS06495	COG0022	dehydrogenase e1 component
A2I69_RS06500	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A2I69_RS06505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A2I69_RS06510	COG3426	butyrate kinase activity
A2I69_RS06515	COG0280	phosphate acetyltransferase
A2I69_RS06520	COG0497	DNA recombination
A2I69_RS06525	COG1438	arginine binding
A2I69_RS06535	COG1722	exodeoxyribonuclease VII activity
A2I69_RS06540	COG1570	exodeoxyribonuclease VII activity
A2I69_RS06545	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A2I69_RS06550	COG1302	Protein conserved in bacteria
A2I69_RS06555	COG0439	Biotin carboxylase
A2I69_RS06560	COG0511	ligase activity, forming carbon-carbon bonds
A2I69_RS06565	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A2I69_RS06570	COG0006	proline dipeptidase activity
A2I69_RS06585	COG0095	Lipoate-protein ligase
A2I69_RS06590	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A2I69_RS06595	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A2I69_RS06600	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A2I69_RS06605	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A2I69_RS06610	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A2I69_RS06640	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A2I69_RS06645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A2I69_RS06650	COG0011	TIGRFAM Protein of
A2I69_RS06655	COG1940	carbohydrate kinase activity
A2I69_RS06660	COG4483	Protein conserved in bacteria
A2I69_RS06665	COG0457	Tetratricopeptide repeat
A2I69_RS06665	COG0705	Rhomboid family
A2I69_RS06670	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A2I69_RS06675	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A2I69_RS06680	COG0768	penicillin binding
A2I69_RS06685	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A2I69_RS06695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A2I69_RS06700	COG1121	(ABC) transporter
A2I69_RS06705	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A2I69_RS06710	COG0513	Belongs to the DEAD box helicase family
A2I69_RS06720	COG2384	SAM-dependent methyltransferase
A2I69_RS06725	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A2I69_RS06735	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A2I69_RS06740	COG0517	IMP dehydrogenase activity
A2I69_RS06745	COG0423	glycine-tRNA ligase activity
A2I69_RS06750	COG1381	Involved in DNA repair and RecF pathway recombination
A2I69_RS06755	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A2I69_RS06760	COG0295	cytidine deaminase activity
A2I69_RS06765	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A2I69_RS06770	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A2I69_RS06775	COG1702	phosphate starvation-inducible protein PhoH
A2I69_RS06785	COG4864	UPF0365 protein
A2I69_RS06790	COG1030	water channel activity
A2I69_RS06795	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A2I69_RS06800	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A2I69_RS06805	COG2264	protein methyltransferase activity
A2I69_RS06810	COG0484	heat shock protein binding
A2I69_RS06815	COG0443	Heat shock 70 kDa protein
A2I69_RS06820	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A2I69_RS06825	COG1420	regulation of RNA biosynthetic process
A2I69_RS06830	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A2I69_RS06835	COG0481	GTPase activity
A2I69_RS06840	COG0268	Binds directly to 16S ribosomal RNA
A2I69_RS06845	COG1466	dna polymerase III delta subunit
A2I69_RS06850	COG0658	competence protein
A2I69_RS06850	COG2333	competence protein COMEC
A2I69_RS06855	COG2131	deaminase
A2I69_RS06860	COG1555	photosystem II stabilization
A2I69_RS06860	COG1596	polysaccharide export
A2I69_RS06865	COG2226	methyltransferase
A2I69_RS06870	COG0799	negative regulation of ribosome biogenesis
A2I69_RS06875	COG1713	HD superfamily hydrolase involved in NAD metabolism
A2I69_RS06880	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A2I69_RS06885	COG1534	Rna-binding protein
A2I69_RS06890	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A2I69_RS06895	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A2I69_RS06900	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A2I69_RS06905	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A2I69_RS06910	COG0730	response to heat
A2I69_RS06915	COG1914	H( )-stimulated, divalent metal cation uptake system
A2I69_RS06920	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A2I69_RS06925	COG0439	Biotin carboxylase
A2I69_RS06930	COG0508	dehydrogenase complex catalyzes the overall conversion of
A2I69_RS06935	COG1984	allophanate hydrolase subunit 2
A2I69_RS06940	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A2I69_RS06945	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A2I69_RS06950	COG0572	uridine kinase
A2I69_RS06955	COG0826	peptidase U32
A2I69_RS06960	COG0826	peptidase U32
A2I69_RS06965	COG4122	O-methyltransferase activity
A2I69_RS06970	COG3906	Belongs to the UPF0473 family
A2I69_RS06975	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A2I69_RS06980	COG4472	Bacterial protein of unknown function (DUF965)
A2I69_RS06985	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A2I69_RS06990	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A2I69_RS07000	COG0482	sulfurtransferase activity
A2I69_RS07005	COG1104	cysteine desulfurase activity
A2I69_RS07010	COG0488	(ABC) transporter
A2I69_RS07015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A2I69_RS07030	COG1959	2 iron, 2 sulfur cluster binding
A2I69_RS07035	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A2I69_RS07040	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A2I69_RS07050	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A2I69_RS07055	COG0124	histidyl-tRNA synthetase
A2I69_RS07060	COG0860	N-Acetylmuramoyl-L-alanine amidase
A2I69_RS07065	COG1490	D-aminoacyl-tRNA deacylase activity
A2I69_RS07070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A2I69_RS07080	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A2I69_RS07080	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A2I69_RS07085	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A2I69_RS07085	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A2I69_RS07090	COG1862	Preprotein translocase
A2I69_RS07095	COG0343	queuine tRNA-ribosyltransferase activity
A2I69_RS07100	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A2I69_RS07105	COG2255	four-way junction helicase activity
A2I69_RS07110	COG0632	four-way junction helicase activity
A2I69_RS07115	COG4492	Belongs to the UPF0735 family
A2I69_RS07120	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A2I69_RS07125	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A2I69_RS07130	COG2868	ribosomal protein
A2I69_RS07135	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A2I69_RS07170	COG2003	Belongs to the UPF0758 family
A2I69_RS07185	COG0285	dihydrofolate synthase activity
A2I69_RS07190	COG0525	valine-tRNA ligase activity
A2I69_RS07195	COG2818	Glycosylase
A2I69_RS07205	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A2I69_RS07210	COG0113	porphobilinogen synthase activity
A2I69_RS07220	COG0181	hydroxymethylbilane synthase activity
A2I69_RS07225	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A2I69_RS07230	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A2I69_RS07235	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A2I69_RS07240	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A2I69_RS07245	COG0544	peptidyl-prolyl cis-trans isomerase activity
A2I69_RS07255	COG4112	unkown
A2I69_RS07260	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A2I69_RS07265	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A2I69_RS07270	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A2I69_RS07275	COG0833	amino acid
A2I69_RS07280	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A2I69_RS07285	COG1484	DNA-dependent DNA replication
A2I69_RS07295	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A2I69_RS07300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A2I69_RS07305	COG0237	dephospho-CoA kinase activity
A2I69_RS07315	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A2I69_RS07315	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A2I69_RS07320	COG5002	protein histidine kinase activity
A2I69_RS07325	COG0745	RESPONSE REGULATOR receiver
A2I69_RS07330	COG0538	isocitrate dehydrogenase activity
A2I69_RS07335	COG0372	Belongs to the citrate synthase family
A2I69_RS07340	COG1113	amino acid transport
A2I69_RS07345	COG0469	pyruvate kinase activity
A2I69_RS07350	COG0205	6-phosphofructokinase activity
A2I69_RS07355	COG0825	malonyl-CoA metabolic process
A2I69_RS07360	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A2I69_RS07365	COG0281	malic enzyme
A2I69_RS07370	COG0587	DNA-directed DNA polymerase activity
A2I69_RS07375	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A2I69_RS07380	COG4109	DRTGG domain
A2I69_RS07390	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A2I69_RS07395	COG0006	proline dipeptidase activity
A2I69_RS07400	COG3142	Participates in the control of copper homeostasis
A2I69_RS07405	COG0686	Belongs to the AlaDH PNT family
A2I69_RS07410	COG0589	response to stress
A2I69_RS07420	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A2I69_RS07425	COG0827	DNA restriction-modification system
A2I69_RS07430	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A2I69_RS07435	COG1714	RDD family
A2I69_RS07440	COG0616	signal peptide processing
A2I69_RS07450	COG0301	tRNA thio-modification
A2I69_RS07455	COG1104	cysteine desulfurase activity
A2I69_RS07460	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
A2I69_RS07465	COG1956	GAF domain-containing protein
A2I69_RS07470	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A2I69_RS07480	COG0584	glycerophosphoryl diester phosphodiesterase
A2I69_RS07485	COG1764	response to oxidative stress
A2I69_RS07490	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A2I69_RS07495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A2I69_RS07505	COG1263	PTS System
A2I69_RS07505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A2I69_RS07510	COG0204	Acyl-transferase
A2I69_RS07515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A2I69_RS07520	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A2I69_RS07535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A2I69_RS07540	COG0454	-acetyltransferase
A2I69_RS07545	COG0123	including yeast histone deacetylase and acetoin utilization protein
A2I69_RS07550	COG1609	Transcriptional regulator
A2I69_RS07555	COG1605	Chorismate mutase
A2I69_RS07555	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A2I69_RS07565	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
A2I69_RS07570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A2I69_RS07575	COG1674	ftsk spoiiie
A2I69_RS07580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A2I69_RS07585	COG4848	Belongs to the UPF0354 family
A2I69_RS07590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A2I69_RS07595	COG1363	Peptidase, m42
A2I69_RS07605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A2I69_RS07610	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A2I69_RS07615	COG0510	thiamine kinase activity
A2I69_RS07620	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A2I69_RS07625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A2I69_RS07635	COG1187	pseudouridine synthase activity
A2I69_RS07640	COG2244	polysaccharide biosynthetic process
A2I69_RS07645	COG2081	HI0933 family
A2I69_RS07655	COG0495	leucyl-tRNA aminoacylation
A2I69_RS07660	COG2814	Major facilitator Superfamily
A2I69_RS07665	COG1242	4 iron, 4 sulfur cluster binding
A2I69_RS07670	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A2I69_RS07680	COG0039	L-malate dehydrogenase activity
A2I69_RS07685	COG2267	carboxylic ester hydrolase activity
A2I69_RS07695	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A2I69_RS07700	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A2I69_RS07700	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A2I69_RS07705	COG0307	riboflavin synthase, alpha
A2I69_RS07710	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A2I69_RS07710	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A2I69_RS07725	COG3266	domain, Protein
A2I69_RS07725	COG4193	domain, Protein
A2I69_RS07725	COG5632	N-Acetylmuramoyl-L-alanine amidase
A2I69_RS07735	COG1595	DNA-templated transcription, initiation
A2I69_RS07755	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A2I69_RS07765	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A2I69_RS07770	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A2I69_RS07775	COG0656	L-ascorbic acid biosynthetic process
A2I69_RS07785	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A2I69_RS07790	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A2I69_RS07795	COG1506	peptidase
A2I69_RS07805	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A2I69_RS07830	COG0300	oxidoreductase activity
A2I69_RS07875	COG3545	Serine hydrolase
A2I69_RS07880	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A2I69_RS07885	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A2I69_RS07890	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A2I69_RS07900	COG4473	ABC transporter
A2I69_RS07905	COG1131	(ABC) transporter
A2I69_RS07910	COG0537	adenosine 5'-monophosphoramidase activity
A2I69_RS07925	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A2I69_RS07930	COG3481	metal-dependent phosphohydrolase, HD sub domain
A2I69_RS07935	COG4717	serine-type aminopeptidase activity
A2I69_RS07940	COG0420	3'-5' exonuclease activity
A2I69_RS07945	COG3679	Belongs to the UPF0342 family
A2I69_RS07950	COG4399	Belongs to the UPF0754 family
A2I69_RS07960	COG0788	formyltetrahydrofolate deformylase activity
A2I69_RS07975	COG1682	transport, permease protein
A2I69_RS07985	COG0730	response to heat
A2I69_RS07990	COG1316	TRANSCRIPTIONal
A2I69_RS07995	COG0772	Belongs to the SEDS family
A2I69_RS08005	COG2197	response regulator
A2I69_RS08010	COG2203	Gaf domain
A2I69_RS08010	COG4585	Histidine kinase
A2I69_RS08015	COG0564	pseudouridine synthase activity
A2I69_RS08020	COG0114	fumarate hydratase activity
A2I69_RS08035	COG0363	glucosamine-6-phosphate deaminase activity
A2I69_RS08045	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A2I69_RS08050	COG1126	abc transporter atp-binding protein
A2I69_RS08055	COG0765	amino acid transport
A2I69_RS08070	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A2I69_RS08220	COG0735	belongs to the Fur family
A2I69_RS08225	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A2I69_RS08230	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A2I69_RS08235	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A2I69_RS08240	COG4129	membrane
A2I69_RS08250	COG3557	Belongs to the UPF0374 family
A2I69_RS08255	COG1194	a g-specific adenine glycosylase
A2I69_RS08260	COG1988	membrane-bound metal-dependent
A2I69_RS08270	COG1134	teichoic acid transport
A2I69_RS08280	COG2137	regulation of response to DNA damage stimulus
A2I69_RS08285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A2I69_RS08290	COG0693	protein deglycase activity
A2I69_RS08300	COG0535	radical SAM domain protein
A2I69_RS08305	COG1607	acyl-coa hydrolase
A2I69_RS08310	COG2309	aminopeptidase activity
A2I69_RS08315	COG4840	Belongs to the UPF0435 family
A2I69_RS08320	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A2I69_RS08330	COG1295	ribonuclease BN
A2I69_RS08335	COG2197	response regulator
A2I69_RS08340	COG4585	Histidine kinase
A2I69_RS08355	COG0024	Methionine aminopeptidase
A2I69_RS08360	COG4129	membrane
A2I69_RS08375	COG1528	Iron-storage protein
A2I69_RS08385	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A2I69_RS08395	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A2I69_RS08400	COG1597	lipid kinase activity
A2I69_RS08405	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A2I69_RS08410	COG0154	amidase activity
A2I69_RS08415	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A2I69_RS08420	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A2I69_RS08425	COG4851	CamS sex pheromone cAM373 precursor
A2I69_RS08430	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A2I69_RS08440	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
A2I69_RS08445	COG1876	peptidase activity
A2I69_RS08450	COG4496	protein, YerC YecD
A2I69_RS08455	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A2I69_RS08465	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
A2I69_RS08470	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A2I69_RS08475	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A2I69_RS08485	COG0077	Prephenate dehydratase
A2I69_RS08490	COG0471	metal ion transport
A2I69_RS08500	COG1335	isochorismatase
A2I69_RS08505	COG1227	inorganic diphosphatase activity
A2I69_RS08510	COG1012	belongs to the aldehyde dehydrogenase family
A2I69_RS08515	COG2706	6-phosphogluconolactonase activity
A2I69_RS08560	COG1131	(ABC) transporter
A2I69_RS08580	COG1725	Transcriptional regulator
A2I69_RS08605	COG0459	protein refolding
A2I69_RS08610	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A2I69_RS08630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A2I69_RS08635	COG4512	PFAM Accessory gene regulator B
A2I69_RS08645	COG3290	protein histidine kinase activity
A2I69_RS08650	COG3279	Response regulator of the LytR AlgR family
A2I69_RS08655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A2I69_RS08660	COG1621	beta-fructofuranosidase activity
A2I69_RS08665	COG1609	Transcriptional regulator
A2I69_RS08670	COG0425	Belongs to the sulfur carrier protein TusA family
A2I69_RS08675	COG2391	methyltransferase activity
A2I69_RS08680	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A2I69_RS08685	COG0488	(ABC) transporter
A2I69_RS08690	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A2I69_RS08700	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A2I69_RS08705	COG0456	acetyltransferase
A2I69_RS08710	COG1214	PFAM Peptidase M22, glycoprotease
A2I69_RS08715	COG0802	atpase or kinase
A2I69_RS08720	COG0129	dihydroxy-acid dehydratase activity
A2I69_RS08725	COG0028	Belongs to the TPP enzyme family
A2I69_RS08730	COG0440	acetolactate synthase activity
A2I69_RS08735	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A2I69_RS08740	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A2I69_RS08745	COG0473	3-isopropylmalate dehydrogenase activity
A2I69_RS08750	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A2I69_RS08755	COG0066	3-isopropylmalate dehydratase activity
A2I69_RS08760	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A2I69_RS08790	COG3091	SprT-like family
A2I69_RS08795	COG2183	response to ionizing radiation
A2I69_RS08800	COG1191	sigma factor activity
A2I69_RS08815	COG2208	phosphoserine phosphatase activity
A2I69_RS08820	COG2337	Toxic component of a toxin-antitoxin (TA) module
A2I69_RS08830	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A2I69_RS08845	COG3428	Bacterial PH domain
A2I69_RS08855	COG0513	Belongs to the DEAD box helicase family
A2I69_RS08860	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A2I69_RS08865	COG1181	Belongs to the D-alanine--D-alanine ligase family
A2I69_RS08870	COG0772	Belongs to the SEDS family
A2I69_RS08885	COG1937	Protein conserved in bacteria
A2I69_RS08895	COG1418	mRNA catabolic process
A2I69_RS08900	COG0706	membrane insertase activity
A2I69_RS08905	COG0352	thiamine-phosphate diphosphorylase activity
A2I69_RS08910	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A2I69_RS08920	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A2I69_RS08925	COG1388	LysM domain
A2I69_RS08930	COG0629	single-stranded DNA binding
A2I69_RS08940	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A2I69_RS08945	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A2I69_RS08955	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A2I69_RS08960	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A2I69_RS08965	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A2I69_RS08970	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A2I69_RS08975	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A2I69_RS08980	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A2I69_RS08985	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A2I69_RS08990	COG0356	it plays a direct role in the translocation of protons across the membrane
A2I69_RS09000	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A2I69_RS09005	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A2I69_RS09010	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A2I69_RS09015	COG4475	Protein of unknown function (DUF436)
A2I69_RS09020	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A2I69_RS09025	COG0009	L-threonylcarbamoyladenylate synthase
A2I69_RS09030	COG2890	protein-(glutamine-N5) methyltransferase activity
A2I69_RS09035	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A2I69_RS09040	COG1435	thymidine kinase activity
A2I69_RS09045	COG0254	rRNA binding
A2I69_RS09050	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A2I69_RS09055	COG1012	belongs to the aldehyde dehydrogenase family
A2I69_RS09065	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A2I69_RS09070	COG0191	fructose-bisphosphate aldolase activity
A2I69_RS09075	COG0504	CTP synthase activity
A2I69_RS09085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A2I69_RS09090	COG5146	pantothenate kinase activity
A2I69_RS09110	COG1854	S-ribosylhomocysteine lyase activity
A2I69_RS09120	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A2I69_RS09125	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A2I69_RS09130	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A2I69_RS09135	COG0813	purine-nucleoside phosphorylase activity
A2I69_RS09140	COG0783	Belongs to the Dps family
A2I69_RS09145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A2I69_RS09160	COG2855	membrane
A2I69_RS09170	COG1482	cell wall glycoprotein biosynthetic process
A2I69_RS09175	COG2186	Transcriptional regulator
A2I69_RS09180	COG0702	epimerase
A2I69_RS09185	COG0640	Transcriptional regulator
A2I69_RS09210	COG1119	ATPase activity
A2I69_RS09225	COG2213	PTS system mannitol-specific
A2I69_RS09230	COG3711	transcriptional antiterminator
A2I69_RS09240	COG0246	Mannitol dehydrogenase
A2I69_RS09245	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A2I69_RS09255	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A2I69_RS09310	COG0489	protein tyrosine kinase activity
A2I69_RS09325	COG1272	protein, Hemolysin III
A2I69_RS09330	COG4284	Utp--glucose-1-phosphate uridylyltransferase
A2I69_RS09335	COG1988	membrane-bound metal-dependent
A2I69_RS09345	COG2329	Antibiotic biosynthesis monooxygenase
A2I69_RS09350	COG3314	Sporulation integral membrane protein YlbJ
A2I69_RS09355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A2I69_RS09360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A2I69_RS09365	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A2I69_RS09370	COG3457	Alanine racemase
A2I69_RS09375	COG4264	IucA IucC family
A2I69_RS09380	COG2814	Major facilitator Superfamily
A2I69_RS09385	COG4264	IucA IucC family
A2I69_RS09390	COG1302	Protein conserved in bacteria
A2I69_RS09405	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A2I69_RS09410	COG0604	alcohol dehydrogenase
A2I69_RS09415	COG2130	NADP-dependent
A2I69_RS09420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A2I69_RS09430	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A2I69_RS09435	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A2I69_RS09440	COG0101	tRNA pseudouridine synthase activity
A2I69_RS09450	COG1122	ATPase activity
A2I69_RS09455	COG1122	ATPase activity
A2I69_RS09460	COG0203	ribosomal protein L17
A2I69_RS09465	COG0202	RNA polymerase activity
A2I69_RS09470	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A2I69_RS09475	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A2I69_RS09480	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A2I69_RS09490	COG0563	adenylate kinase activity
A2I69_RS09495	COG0201	protein transport
A2I69_RS09500	COG0200	Binds to the 23S rRNA
A2I69_RS09505	COG1841	ribosomal large subunit assembly
A2I69_RS09510	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A2I69_RS09515	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A2I69_RS09520	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A2I69_RS09525	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A2I69_RS09530	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A2I69_RS09535	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A2I69_RS09540	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A2I69_RS09545	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A2I69_RS09550	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A2I69_RS09555	COG0255	Belongs to the universal ribosomal protein uL29 family
A2I69_RS09560	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A2I69_RS09565	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A2I69_RS09570	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A2I69_RS09575	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A2I69_RS09580	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A2I69_RS09585	COG0089	rRNA binding
A2I69_RS09590	COG0088	Forms part of the polypeptide exit tunnel
A2I69_RS09595	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A2I69_RS09600	COG0051	transcription antitermination factor activity, RNA binding
A2I69_RS09610	COG2252	PERMEase
A2I69_RS09615	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A2I69_RS09615	COG0551	DNA topoisomerase type I activity
A2I69_RS09625	COG4975	Glucose uptake
A2I69_RS09650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A2I69_RS09655	COG2348	transferase activity, transferring amino-acyl groups
A2I69_RS09680	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A2I69_RS09685	COG0746	molybdenum cofactor guanylyltransferase activity
A2I69_RS09710	COG0315	cyclic pyranopterin monophosphate synthase activity
A2I69_RS09715	COG0521	Mo-molybdopterin cofactor biosynthetic process
A2I69_RS09720	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A2I69_RS09725	COG1510	regulation of RNA biosynthetic process
A2I69_RS09730	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A2I69_RS09735	COG4149	molybdate abc transporter
A2I69_RS09740	COG0725	ABC transporter, periplasmic molybdate-binding protein
A2I69_RS09745	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
A2I69_RS09750	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A2I69_RS09755	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A2I69_RS09760	COG1609	Transcriptional regulator
A2I69_RS09765	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A2I69_RS09775	COG1268	BioY protein
A2I69_RS09780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A2I69_RS09785	COG1960	acyl-CoA dehydrogenase activity
A2I69_RS09790	COG1126	abc transporter atp-binding protein
A2I69_RS09795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A2I69_RS09800	COG0765	amino acid transport
A2I69_RS09805	COG0765	amino acid transport
A2I69_RS09830	COG3942	CHAP domain
A2I69_RS09835	COG1757	Na H antiporter
A2I69_RS09850	COG3942	CHAP domain
A2I69_RS09855	COG2076	Multidrug Resistance protein
A2I69_RS09860	COG2076	Multidrug Resistance protein
A2I69_RS09865	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A2I69_RS09895	COG3383	formate dehydrogenase (NAD+) activity
A2I69_RS09900	COG1316	TRANSCRIPTIONal
A2I69_RS09925	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A2I69_RS09930	COG1263	PTS System
A2I69_RS09930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A2I69_RS09940	COG1785	Belongs to the alkaline phosphatase family
A2I69_RS09945	COG1113	amino acid transport
A2I69_RS09970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A2I69_RS09975	COG0385	Bile acid
A2I69_RS09985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A2I69_RS09985	COG1263	PTS System
A2I69_RS10005	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A2I69_RS10010	COG1028	Short-chain dehydrogenase reductase Sdr
A2I69_RS10015	COG1473	amidohydrolase
A2I69_RS10020	COG0659	secondary active sulfate transmembrane transporter activity
A2I69_RS10025	COG1228	amidohydrolase
A2I69_RS10030	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A2I69_RS10035	COG3314	Sporulation integral membrane protein YlbJ
A2I69_RS10040	COG0583	DNA-binding transcription factor activity
A2I69_RS10045	COG0010	Belongs to the arginase family
A2I69_RS10050	COG1266	CAAX protease self-immunity
A2I69_RS10055	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A2I69_RS10060	COG2258	MOSC domain
A2I69_RS10065	COG2017	converts alpha-aldose to the beta-anomer
A2I69_RS10070	COG1668	transmembrane transport
A2I69_RS10075	COG4152	abc transporter atp-binding protein
A2I69_RS10080	COG1069	ribulokinase activity
A2I69_RS10085	COG3152	Membrane
A2I69_RS10090	COG2094	Belongs to the DNA glycosylase MPG family
A2I69_RS10095	COG1757	Na H antiporter
A2I69_RS10115	COG0786	glutamate:sodium symporter activity
A2I69_RS10120	COG1304	FMN binding
A2I69_RS10125	COG0598	Magnesium transport protein CorA
A2I69_RS10150	COG2814	Major facilitator Superfamily
A2I69_RS10155	COG1566	PFAM secretion protein HlyD family protein
A2I69_RS10165	COG2814	Major facilitator Superfamily
A2I69_RS10170	COG4640	response to antibiotic
A2I69_RS10185	COG1136	(ABC) transporter
A2I69_RS10190	COG0577	efflux transmembrane transporter activity
A2I69_RS10195	COG0745	RESPONSE REGULATOR receiver
A2I69_RS10200	COG3850	Histidine kinase
A2I69_RS10200	COG5002	protein histidine kinase activity
A2I69_RS10210	COG0438	transferase activity, transferring glycosyl groups
A2I69_RS10215	COG1620	l-lactate permease
A2I69_RS10220	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A2I69_RS10235	COG0604	alcohol dehydrogenase
A2I69_RS10240	COG2814	Major facilitator Superfamily
A2I69_RS10250	COG0492	ferredoxin-NADP+ reductase activity
A2I69_RS10260	COG0698	ribose 5-phosphate isomerase
A2I69_RS10270	COG2376	Dihydroxyacetone kinase
A2I69_RS10275	COG1063	alcohol dehydrogenase
A2I69_RS10280	COG1349	DNA-binding transcription factor activity
A2I69_RS10285	COG1288	antiporter activity
A2I69_RS10290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A2I69_RS10295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A2I69_RS10300	COG1028	Short-chain dehydrogenase reductase Sdr
A2I69_RS10305	COG1283	sodium-dependent phosphate transmembrane transporter activity
A2I69_RS10325	COG1263	PTS System
A2I69_RS10325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A2I69_RS10350	COG1846	Transcriptional regulator
A2I69_RS10360	COG0071	Belongs to the small heat shock protein (HSP20) family
A2I69_RS10365	COG2223	nitrite transmembrane transporter activity
A2I69_RS10375	COG4585	Histidine kinase
A2I69_RS10385	COG2181	nitrate reductase activity
A2I69_RS10400	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A2I69_RS10420	COG2146	nitrite reductase [NAD(P)H] activity
A2I69_RS10425	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A2I69_RS10440	COG0454	-acetyltransferase
A2I69_RS10445	COG2116	formate transmembrane transporter activity
A2I69_RS10450	COG2188	Transcriptional regulator
A2I69_RS10455	COG1263	PTS System
A2I69_RS10455	COG2190	(PTS) system
A2I69_RS10455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A2I69_RS10460	COG2723	6-phospho-beta-galactosidase activity
A2I69_RS10480	COG1695	Transcriptional regulator
A2I69_RS10490	COG2353	YceI-like domain
A2I69_RS10495	COG0803	Belongs to the bacterial solute-binding protein 9 family
A2I69_RS10495	COG3443	Belongs to the bacterial solute-binding protein 9 family
A2I69_RS10500	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A2I69_RS10515	COG2814	Major facilitator Superfamily
A2I69_RS10525	COG0588	phosphoglycerate mutase activity
A2I69_RS10530	COG1388	LysM domain
A2I69_RS10535	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A2I69_RS10545	COG2814	Major facilitator Superfamily
A2I69_RS10565	COG0025	NhaP-type Na H and K H
A2I69_RS10570	COG0706	membrane insertase activity
A2I69_RS10580	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
A2I69_RS10600	COG4187	Peptidase family M20/M25/M40
A2I69_RS10610	COG3275	phosphorelay sensor kinase activity
A2I69_RS10615	COG3279	Response regulator of the LytR AlgR family
A2I69_RS10620	COG1380	Effector of murein hydrolase LrgA
A2I69_RS10625	COG1346	cytolysis
A2I69_RS10635	COG1174	glycine betaine transport
A2I69_RS10645	COG1174	glycine betaine transport
A2I69_RS10660	COG1250	3-hydroxyacyl-CoA dehydrogenase
A2I69_RS10665	COG3246	L-lysine catabolic process to acetate
A2I69_RS10670	COG1309	transcriptional regulator
A2I69_RS10675	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
A2I69_RS10680	COG0531	amino acid
A2I69_RS10685	COG2851	Citrate transporter
A2I69_RS10690	COG2814	Major facilitator Superfamily
A2I69_RS10695	COG0390	transport system, permease component
A2I69_RS10700	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A2I69_RS10710	COG0069	glutamate synthase activity
A2I69_RS10720	COG1363	Peptidase, m42
A2I69_RS10725	COG1028	Short-chain dehydrogenase reductase Sdr
A2I69_RS10730	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A2I69_RS10735	COG0248	Ppx GppA phosphatase
A2I69_RS10740	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A2I69_RS10745	COG3048	D-serine ammonia-lyase activity
A2I69_RS10755	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A2I69_RS10760	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A2I69_RS10765	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A2I69_RS10770	COG0131	Imidazoleglycerol-phosphate dehydratase
A2I69_RS10775	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A2I69_RS10780	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A2I69_RS10785	COG0107	imidazoleglycerol-phosphate synthase activity
A2I69_RS10815	COG4221	oxidoreductase activity
A2I69_RS10830	COG1312	Catalyzes the dehydration of D-mannonate
A2I69_RS10835	COG1904	glucuronate isomerase
A2I69_RS10840	COG2211	Major facilitator Superfamily
A2I69_RS10845	COG0800	Aldolase
A2I69_RS10860	COG3250	beta-galactosidase activity
A2I69_RS10865	COG2211	Major facilitator Superfamily
A2I69_RS10875	COG3949	Membrane
A2I69_RS10880	COG1028	Short-chain dehydrogenase reductase Sdr
A2I69_RS10885	COG2610	gluconate transmembrane transporter activity
A2I69_RS10890	COG1070	Carbohydrate kinase
A2I69_RS10895	COG1802	Transcriptional regulator
A2I69_RS10905	COG2357	RelA SpoT domain protein
A2I69_RS10910	COG4876	unkown
A2I69_RS10925	COG1289	transmembrane transporter activity
A2I69_RS10930	COG3527	Alpha-acetolactate decarboxylase
A2I69_RS10940	COG2271	Major facilitator Superfamily
A2I69_RS10945	COG0586	Pfam SNARE associated Golgi protein
A2I69_RS10950	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A2I69_RS10955	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
A2I69_RS10965	COG3949	Membrane
A2I69_RS10970	COG0471	metal ion transport
A2I69_RS10980	COG0400	carboxylic ester hydrolase activity
A2I69_RS10985	COG0346	lactoylglutathione lyase activity
A2I69_RS10990	COG0346	lactoylglutathione lyase activity
A2I69_RS10995	COG1846	Transcriptional regulator
A2I69_RS11000	COG1012	belongs to the aldehyde dehydrogenase family
A2I69_RS11005	COG0803	Belongs to the bacterial solute-binding protein 9 family
A2I69_RS11015	COG1132	(ABC) transporter
A2I69_RS11020	COG1132	(ABC) transporter
A2I69_RS11030	COG2514	catechol 2,3-dioxygenase activity
A2I69_RS11035	COG0778	Nitroreductase
A2I69_RS11040	COG0561	phosphatase activity
A2I69_RS11045	COG2249	NAD(P)H dehydrogenase (quinone) activity
A2I69_RS11065	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A2I69_RS11070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A2I69_RS11080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A2I69_RS11085	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
A2I69_RS11090	COG3764	Sortase (surface protein transpeptidase)
A2I69_RS11100	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A2I69_RS11115	COG1063	alcohol dehydrogenase
A2I69_RS11120	COG1070	Carbohydrate kinase
A2I69_RS11140	COG1129	ABC transporter
A2I69_RS11160	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A2I69_RS11165	COG1063	alcohol dehydrogenase
A2I69_RS11170	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A2I69_RS11190	COG2843	Capsule synthesis protein
A2I69_RS11200	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A2I69_RS11215	COG0657	acetylesterase activity
A2I69_RS11235	COG2515	1-aminocyclopropane-1-carboxylate deaminase
A2I69_RS11250	COG1263	PTS System
A2I69_RS11250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A2I69_RS11250	COG2190	(PTS) system
A2I69_RS11255	COG1288	antiporter activity
A2I69_RS11260	COG0028	Belongs to the TPP enzyme family
A2I69_RS11270	COG1380	Effector of murein hydrolase LrgA
A2I69_RS11275	COG0583	DNA-binding transcription factor activity
A2I69_RS11280	COG1757	Na H antiporter
A2I69_RS11285	COG3942	CHAP domain
A2I69_RS11290	COG3386	PFAM SMP-30 Gluconolaconase
A2I69_RS11305	COG3425	synthase
A2I69_RS11315	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A2I69_RS11340	COG1473	amidohydrolase
A2I69_RS11365	COG1012	belongs to the aldehyde dehydrogenase family
A2I69_RS11370	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
A2I69_RS11380	COG4336	lyase activity
A2I69_RS11395	COG5505	Protein of unknown function (DUF819)
A2I69_RS11400	COG0471	metal ion transport
A2I69_RS11425	COG1136	(ABC) transporter
A2I69_RS11435	COG1028	Short-chain dehydrogenase reductase Sdr
A2I69_RS11440	COG0577	efflux transmembrane transporter activity
A2I69_RS11445	COG1136	(ABC) transporter
A2I69_RS11450	COG0659	secondary active sulfate transmembrane transporter activity
A2I69_RS11455	COG2217	Heavy metal translocating P-type atpase
A2I69_RS11460	COG2608	mercury ion transmembrane transporter activity
A2I69_RS11470	COG0436	Aminotransferase
A2I69_RS11475	COG1388	LysM domain
A2I69_RS11490	COG3189	MarR family transcriptional regulator
A2I69_RS11505	COG1113	amino acid transport
A2I69_RS11510	COG0697	spore germination
A2I69_RS11535	COG3001	Fructosamine kinase
A2I69_RS11540	COG0167	dihydroorotate dehydrogenase activity
A2I69_RS11550	COG0561	phosphatase activity
A2I69_RS11560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A2I69_RS11565	COG0531	amino acid
A2I69_RS11575	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A2I69_RS11600	COG0747	negative chemotaxis
A2I69_RS11605	COG4413	Urea transporter
A2I69_RS11610	COG0831	urea catabolic process
A2I69_RS11615	COG0832	Belongs to the urease beta subunit family
A2I69_RS11620	COG0804	urea catabolic process
A2I69_RS11625	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
A2I69_RS11630	COG0830	nickel cation binding
A2I69_RS11635	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A2I69_RS11640	COG0829	nickel cation binding
A2I69_RS11665	COG0626	cystathionine gamma-synthase activity
A2I69_RS11670	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A2I69_RS11690	COG1940	carbohydrate kinase activity
A2I69_RS11695	COG1482	cell wall glycoprotein biosynthetic process
A2I69_RS11700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A2I69_RS11700	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A2I69_RS11700	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A2I69_RS11705	COG3711	transcriptional antiterminator
A2I69_RS11705	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A2I69_RS11710	COG0039	L-malate dehydrogenase activity
A2I69_RS11715	COG1464	Belongs to the NlpA lipoprotein family
A2I69_RS11725	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A2I69_RS11735	COG4297	protein containing double-stranded beta helix domain
A2I69_RS11740	COG3037	sugar-specific permease SgaT UlaA
A2I69_RS11750	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A2I69_RS11755	COG3711	transcriptional antiterminator
A2I69_RS11760	COG1126	abc transporter atp-binding protein
A2I69_RS11765	COG0765	amino acid transport
A2I69_RS11770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A2I69_RS11785	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A2I69_RS11795	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A2I69_RS11805	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A2I69_RS11820	COG0363	glucosamine-6-phosphate deaminase activity
A2I69_RS11825	COG2190	(PTS) system
A2I69_RS11825	COG1263	PTS System
A2I69_RS11825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A2I69_RS11830	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A2I69_RS11835	COG2814	Major facilitator Superfamily
A2I69_RS11840	COG1620	l-lactate permease
A2I69_RS11845	COG1063	alcohol dehydrogenase
A2I69_RS11850	COG2610	gluconate transmembrane transporter activity
A2I69_RS11870	COG3226	Transcriptional regulator
A2I69_RS11875	COG0431	NADPH-dependent FMN reductase
A2I69_RS11880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A2I69_RS11885	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A2I69_RS11890	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A2I69_RS11895	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A2I69_RS11900	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A2I69_RS11905	COG0531	amino acid
A2I69_RS11910	COG1131	(ABC) transporter
A2I69_RS11930	COG0477	Major facilitator Superfamily
A2I69_RS11935	COG1957	nucleoside hydrolase
A2I69_RS11940	COG2843	Capsule synthesis protein
A2I69_RS11945	COG0778	Nitroreductase
A2I69_RS11955	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A2I69_RS11955	COG0463	Glycosyl transferase, family 2
A2I69_RS11965	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A2I69_RS11970	COG1012	belongs to the aldehyde dehydrogenase family
A2I69_RS11975	COG1510	regulation of RNA biosynthetic process
A2I69_RS11980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A2I69_RS11985	COG2226	methyltransferase
A2I69_RS12000	COG0531	amino acid
A2I69_RS12005	COG1012	belongs to the aldehyde dehydrogenase family
A2I69_RS12010	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A2I69_RS12015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A2I69_RS12025	COG2807	transmembrane transport
A2I69_RS12030	COG1476	TRANSCRIPTIONal
A2I69_RS12050	COG2764	glyoxalase bleomycin resistance protein dioxygenase
A2I69_RS12055	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A2I69_RS12060	COG0574	Belongs to the PEP-utilizing enzyme family
A2I69_RS12060	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A2I69_RS12070	COG3835	regulator
A2I69_RS12075	COG1929	Belongs to the glycerate kinase type-1 family
A2I69_RS12085	COG3875	lactate racemase activity
A2I69_RS12090	COG1606	tRNA processing
A2I69_RS12095	COG1691	(AIR) carboxylase
A2I69_RS12100	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
A2I69_RS12105	COG0673	inositol 2-dehydrogenase activity
A2I69_RS12140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A2I69_RS12160	COG3961	Belongs to the TPP enzyme family
A2I69_RS12165	COG1846	Transcriptional regulator
A2I69_RS12170	COG0668	transmembrane transport
A2I69_RS12180	COG0584	glycerophosphoryl diester phosphodiesterase
A2I69_RS12190	COG2814	Major facilitator Superfamily
A2I69_RS12195	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A2I69_RS12210	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A2I69_RS12230	COG0579	oxidoreductase
A2I69_RS12235	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A2I69_RS12240	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A2I69_RS12290	COG2084	Dehydrogenase
A2I69_RS12295	COG2188	Transcriptional regulator
A2I69_RS12300	COG0346	lactoylglutathione lyase activity
A2I69_RS12310	COG0431	NADPH-dependent FMN reductase
A2I69_RS12325	COG0602	queuosine metabolic process
A2I69_RS12330	COG1328	CTP reductase activity
A2I69_RS12335	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A2I69_RS12340	COG2022	thiamine diphosphate biosynthetic process
A2I69_RS12350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A2I69_RS12355	COG0352	thiamine-phosphate diphosphorylase activity
A2I69_RS12360	COG1070	Carbohydrate kinase
A2I69_RS12370	COG2207	Transcriptional regulator
A2I69_RS12370	COG1917	Cupin 2, conserved barrel domain protein
A2I69_RS12385	COG1511	domain protein
A2I69_RS12390	COG1846	Transcriptional regulator
A2I69_RS12390	COG1940	carbohydrate kinase activity
A2I69_RS12395	COG2115	Belongs to the xylose isomerase family
A2I69_RS12400	COG1070	Carbohydrate kinase
A2I69_RS12405	COG2814	Major facilitator Superfamily
A2I69_RS12405	COG0477	Major facilitator Superfamily
A2I69_RS12410	COG3479	Phenolic acid decarboxylase
A2I69_RS12415	COG1695	Transcriptional regulator
A2I69_RS12425	COG1131	(ABC) transporter
A2I69_RS12440	COG2160	L-arabinose isomerase activity
A2I69_RS12445	COG0235	Class ii aldolase
A2I69_RS12455	COG1609	Transcriptional regulator
A2I69_RS12460	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A2I69_RS12460	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A2I69_RS12465	COG1054	Belongs to the UPF0176 family
A2I69_RS12475	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A2I69_RS12480	COG1388	LysM domain
A2I69_RS12485	COG1388	LysM domain
A2I69_RS12510	COG2318	DinB family
A2I69_RS12520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A2I69_RS12525	COG1012	belongs to the aldehyde dehydrogenase family
A2I69_RS12535	COG1028	Short-chain dehydrogenase reductase Sdr
A2I69_RS12540	COG3192	ethanolamine utilization protein
A2I69_RS12555	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A2I69_RS12560	COG1028	Short-chain dehydrogenase reductase Sdr
A2I69_RS12565	COG1695	Transcriptional regulator
A2I69_RS12585	COG0463	Glycosyl transferase, family 2
A2I69_RS12590	COG2814	Major facilitator Superfamily
A2I69_RS12615	COG2814	Major facilitator Superfamily
A2I69_RS12620	COG2814	Major facilitator Superfamily
A2I69_RS12625	COG1476	TRANSCRIPTIONal
A2I69_RS12635	COG4555	ABC transporter
A2I69_RS12645	COG3250	beta-galactosidase activity
A2I69_RS12650	COG2211	Major facilitator Superfamily
A2I69_RS12655	COG2207	Transcriptional regulator
A2I69_RS12660	COG0583	DNA-binding transcription factor activity
A2I69_RS12690	COG1124	(ABC) transporter
A2I69_RS12695	COG0444	Belongs to the ABC transporter superfamily
A2I69_RS12705	COG0601	transmembrane transport
A2I69_RS12730	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A2I69_RS12735	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A2I69_RS12740	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A2I69_RS12745	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A2I69_RS12760	COG2723	6-phospho-beta-galactosidase activity
A2I69_RS12765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A2I69_RS12765	COG1263	PTS System
A2I69_RS12770	COG3711	transcriptional antiterminator
A2I69_RS12785	COG0415	Belongs to the DNA photolyase family
A2I69_RS12820	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
A2I69_RS12825	COG0702	epimerase
A2I69_RS12840	COG1136	(ABC) transporter
A2I69_RS12850	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A2I69_RS12855	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
A2I69_RS12865	COG1942	4-Oxalocrotonate Tautomerase
A2I69_RS12870	COG0191	fructose-bisphosphate aldolase activity
A2I69_RS12875	COG0673	inositol 2-dehydrogenase activity
A2I69_RS12880	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A2I69_RS12885	COG1082	Xylose isomerase domain protein TIM barrel
A2I69_RS12890	COG0673	inositol 2-dehydrogenase activity
A2I69_RS12895	COG3962	Belongs to the TPP enzyme family
A2I69_RS12900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A2I69_RS12905	COG3718	enzyme involved in inositol metabolism
A2I69_RS12910	COG1012	belongs to the aldehyde dehydrogenase family
A2I69_RS12915	COG1349	DNA-binding transcription factor activity
A2I69_RS12920	COG3711	transcriptional antiterminator
A2I69_RS12930	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A2I69_RS12935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A2I69_RS12940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A2I69_RS12940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A2I69_RS12940	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A2I69_RS12945	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A2I69_RS12955	COG1401	restriction endodeoxyribonuclease activity
A2I69_RS12965	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A2I69_RS12970	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A2I69_RS12980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A2I69_RS12985	COG2210	Belongs to the sulfur carrier protein TusA family
A2I69_RS12990	COG1937	Protein conserved in bacteria
A2I69_RS12995	COG0730	response to heat
A2I69_RS13000	COG1388	LysM domain
A2I69_RS13015	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A2I69_RS13050	COG1620	l-lactate permease
A2I69_RS13055	COG3527	Alpha-acetolactate decarboxylase
A2I69_RS13060	COG0028	Belongs to the TPP enzyme family
A2I69_RS13065	COG0579	oxidoreductase
A2I69_RS13085	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A2I69_RS13090	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A2I69_RS13100	COG2211	Major facilitator Superfamily
A2I69_RS13115	COG5002	protein histidine kinase activity
A2I69_RS13120	COG0745	RESPONSE REGULATOR receiver
A2I69_RS13135	COG1819	glycosyl
A2I69_RS13140	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A2I69_RS13145	COG0305	Participates in initiation and elongation during chromosome replication
A2I69_RS13150	COG0359	binds to the 23S rRNA
A2I69_RS13155	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
A2I69_RS13165	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A2I69_RS13175	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A2I69_RS13180	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A2I69_RS13185	COG2986	histidine ammonia-lyase
A2I69_RS13190	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A2I69_RS13205	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A2I69_RS13210	COG2501	S4 domain
A2I69_RS13215	COG0592	DNA-directed DNA polymerase activity
A2I69_RS13220	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids