locus-tag	class	description
A2I73_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A2I73_RS00010	COG0592	DNA-directed DNA polymerase activity
A2I73_RS00015	COG2501	S4 domain
A2I73_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A2I73_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A2I73_RS00035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A2I73_RS00040	COG2986	histidine ammonia-lyase
A2I73_RS00045	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A2I73_RS00050	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A2I73_RS00060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A2I73_RS00070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
A2I73_RS00075	COG0359	binds to the 23S rRNA
A2I73_RS00080	COG0305	Participates in initiation and elongation during chromosome replication
A2I73_RS00085	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A2I73_RS00090	COG1819	glycosyl
A2I73_RS00105	COG0745	RESPONSE REGULATOR receiver
A2I73_RS00110	COG5002	protein histidine kinase activity
A2I73_RS00125	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A2I73_RS00130	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A2I73_RS00165	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A2I73_RS00170	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A2I73_RS00175	COG0438	transferase activity, transferring glycosyl groups
A2I73_RS00190	COG1388	LysM domain
A2I73_RS00195	COG0730	response to heat
A2I73_RS00200	COG1937	Protein conserved in bacteria
A2I73_RS00205	COG2210	Belongs to the sulfur carrier protein TusA family
A2I73_RS00210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A2I73_RS00220	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A2I73_RS00225	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A2I73_RS00300	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A2I73_RS00340	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A2I73_RS00345	COG0110	maltose O-acetyltransferase activity
A2I73_RS00350	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A2I73_RS00355	COG1316	TRANSCRIPTIONal
A2I73_RS00360	COG0513	Belongs to the DEAD box helicase family
A2I73_RS00365	COG0494	nUDIX hydrolase
A2I73_RS00385	COG0583	DNA-binding transcription factor activity
A2I73_RS00395	COG3181	Tripartite tricarboxylate transporter family receptor
A2I73_RS00420	COG1349	DNA-binding transcription factor activity
A2I73_RS00425	COG1012	belongs to the aldehyde dehydrogenase family
A2I73_RS00430	COG3718	enzyme involved in inositol metabolism
A2I73_RS00435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A2I73_RS00440	COG3962	Belongs to the TPP enzyme family
A2I73_RS00445	COG0673	inositol 2-dehydrogenase activity
A2I73_RS00450	COG1082	Xylose isomerase domain protein TIM barrel
A2I73_RS00455	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A2I73_RS00460	COG0673	inositol 2-dehydrogenase activity
A2I73_RS00465	COG0191	fructose-bisphosphate aldolase activity
A2I73_RS00470	COG1942	4-Oxalocrotonate Tautomerase
A2I73_RS00480	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
A2I73_RS00485	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A2I73_RS00495	COG1136	(ABC) transporter
A2I73_RS00500	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A2I73_RS00505	COG2814	Major facilitator Superfamily
A2I73_RS00515	COG0702	epimerase
A2I73_RS00520	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
A2I73_RS00555	COG0415	Belongs to the DNA photolyase family
A2I73_RS00570	COG3711	transcriptional antiterminator
A2I73_RS00575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A2I73_RS00575	COG1263	PTS System
A2I73_RS00580	COG2723	6-phospho-beta-galactosidase activity
A2I73_RS00595	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A2I73_RS00600	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A2I73_RS00625	COG0601	transmembrane transport
A2I73_RS00640	COG1124	(ABC) transporter
A2I73_RS00670	COG0583	DNA-binding transcription factor activity
A2I73_RS00675	COG2207	Transcriptional regulator
A2I73_RS00680	COG2211	Major facilitator Superfamily
A2I73_RS00685	COG3250	beta-galactosidase activity
A2I73_RS00695	COG4555	ABC transporter
A2I73_RS00705	COG1476	TRANSCRIPTIONal
A2I73_RS00715	COG0583	DNA-binding transcription factor activity
A2I73_RS00730	COG2814	Major facilitator Superfamily
A2I73_RS00755	COG2814	Major facilitator Superfamily
A2I73_RS00760	COG0463	Glycosyl transferase, family 2
A2I73_RS00780	COG1695	Transcriptional regulator
A2I73_RS00785	COG1028	Short-chain dehydrogenase reductase Sdr
A2I73_RS00790	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A2I73_RS00795	COG1063	alcohol dehydrogenase
A2I73_RS00805	COG1063	alcohol dehydrogenase
A2I73_RS00810	COG3775	system Galactitol-specific IIC component
A2I73_RS00815	COG3414	Phosphotransferase system galactitol-specific IIB component
A2I73_RS00860	COG3192	ethanolamine utilization protein
A2I73_RS00865	COG1028	Short-chain dehydrogenase reductase Sdr
A2I73_RS00875	COG1012	belongs to the aldehyde dehydrogenase family
A2I73_RS00880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A2I73_RS00890	COG2318	DinB family
A2I73_RS00910	COG5002	protein histidine kinase activity
A2I73_RS00915	COG1388	LysM domain
A2I73_RS00920	COG1388	LysM domain
A2I73_RS00925	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A2I73_RS00935	COG1054	Belongs to the UPF0176 family
A2I73_RS00940	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A2I73_RS00940	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A2I73_RS00945	COG1609	Transcriptional regulator
A2I73_RS00955	COG0235	Class ii aldolase
A2I73_RS00960	COG2160	L-arabinose isomerase activity
A2I73_RS00975	COG1131	(ABC) transporter
A2I73_RS00985	COG1695	Transcriptional regulator
A2I73_RS00990	COG3479	Phenolic acid decarboxylase
A2I73_RS00995	COG0477	Major facilitator Superfamily
A2I73_RS00995	COG2814	Major facilitator Superfamily
A2I73_RS01000	COG1070	Carbohydrate kinase
A2I73_RS01005	COG2115	Belongs to the xylose isomerase family
A2I73_RS01010	COG1940	carbohydrate kinase activity
A2I73_RS01010	COG1846	Transcriptional regulator
A2I73_RS01015	COG1511	domain protein
A2I73_RS01030	COG2207	Transcriptional regulator
A2I73_RS01030	COG1917	Cupin 2, conserved barrel domain protein
A2I73_RS01045	COG1070	Carbohydrate kinase
A2I73_RS01050	COG0352	thiamine-phosphate diphosphorylase activity
A2I73_RS01055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A2I73_RS01065	COG2022	thiamine diphosphate biosynthetic process
A2I73_RS01070	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A2I73_RS01075	COG1328	CTP reductase activity
A2I73_RS01080	COG0602	queuosine metabolic process
A2I73_RS01100	COG0431	NADPH-dependent FMN reductase
A2I73_RS01110	COG0346	lactoylglutathione lyase activity
A2I73_RS01115	COG2188	Transcriptional regulator
A2I73_RS01120	COG2084	Dehydrogenase
A2I73_RS01145	COG2311	Membrane
A2I73_RS01160	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A2I73_RS01165	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A2I73_RS01170	COG0579	oxidoreductase
A2I73_RS01200	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A2I73_RS01220	COG2814	Major facilitator Superfamily
A2I73_RS01230	COG0584	glycerophosphoryl diester phosphodiesterase
A2I73_RS01240	COG0668	transmembrane transport
A2I73_RS01245	COG1846	Transcriptional regulator
A2I73_RS01250	COG3961	Belongs to the TPP enzyme family
A2I73_RS01260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A2I73_RS01300	COG0673	inositol 2-dehydrogenase activity
A2I73_RS01305	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
A2I73_RS01310	COG1691	(AIR) carboxylase
A2I73_RS01315	COG1606	tRNA processing
A2I73_RS01320	COG3875	lactate racemase activity
A2I73_RS01335	COG3835	regulator
A2I73_RS01340	COG0574	Belongs to the PEP-utilizing enzyme family
A2I73_RS01340	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A2I73_RS01345	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A2I73_RS01350	COG2764	glyoxalase bleomycin resistance protein dioxygenase
A2I73_RS01370	COG1476	TRANSCRIPTIONal
A2I73_RS01375	COG2807	transmembrane transport
A2I73_RS01385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A2I73_RS01390	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A2I73_RS01395	COG1012	belongs to the aldehyde dehydrogenase family
A2I73_RS01400	COG0531	amino acid
A2I73_RS01420	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A2I73_RS01425	COG1510	regulation of RNA biosynthetic process
A2I73_RS01430	COG1012	belongs to the aldehyde dehydrogenase family
A2I73_RS01435	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A2I73_RS01440	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A2I73_RS01440	COG0463	Glycosyl transferase, family 2
A2I73_RS01450	COG0778	Nitroreductase
A2I73_RS01455	COG2843	Capsule synthesis protein
A2I73_RS01465	COG0477	Major facilitator Superfamily
A2I73_RS01470	COG0531	amino acid
A2I73_RS01475	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A2I73_RS01480	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A2I73_RS01485	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A2I73_RS01490	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A2I73_RS01495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A2I73_RS01505	COG0431	NADPH-dependent FMN reductase
A2I73_RS01520	COG2610	gluconate transmembrane transporter activity
A2I73_RS01525	COG1063	alcohol dehydrogenase
A2I73_RS01530	COG1620	l-lactate permease
A2I73_RS01535	COG2814	Major facilitator Superfamily
A2I73_RS01540	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A2I73_RS01545	COG1263	PTS System
A2I73_RS01545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A2I73_RS01545	COG2190	(PTS) system
A2I73_RS01550	COG0363	glucosamine-6-phosphate deaminase activity
A2I73_RS01555	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A2I73_RS01570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A2I73_RS01575	COG0765	amino acid transport
A2I73_RS01580	COG1126	abc transporter atp-binding protein
A2I73_RS01585	COG3711	transcriptional antiterminator
A2I73_RS01590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A2I73_RS01600	COG3037	sugar-specific permease SgaT UlaA
A2I73_RS01605	COG4297	protein containing double-stranded beta helix domain
A2I73_RS01615	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A2I73_RS01625	COG1464	Belongs to the NlpA lipoprotein family
A2I73_RS01630	COG0039	L-malate dehydrogenase activity
A2I73_RS01650	COG3711	transcriptional antiterminator
A2I73_RS01650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A2I73_RS01655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A2I73_RS01655	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A2I73_RS01655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A2I73_RS01660	COG1482	cell wall glycoprotein biosynthetic process
A2I73_RS01665	COG1940	carbohydrate kinase activity
A2I73_RS01685	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A2I73_RS01690	COG0626	cystathionine gamma-synthase activity
A2I73_RS01715	COG0829	nickel cation binding
A2I73_RS01720	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A2I73_RS01725	COG0830	nickel cation binding
A2I73_RS01730	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
A2I73_RS01735	COG0804	urea catabolic process
A2I73_RS01740	COG0832	Belongs to the urease beta subunit family
A2I73_RS01745	COG0831	urea catabolic process
A2I73_RS01750	COG4413	Urea transporter
A2I73_RS01755	COG0747	negative chemotaxis
A2I73_RS01780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A2I73_RS01790	COG0531	amino acid
A2I73_RS01810	COG0561	phosphatase activity
A2I73_RS01825	COG3001	Fructosamine kinase
A2I73_RS01850	COG0697	spore germination
A2I73_RS01855	COG1113	amino acid transport
A2I73_RS01870	COG3189	MarR family transcriptional regulator
A2I73_RS01885	COG1388	LysM domain
A2I73_RS01890	COG0436	Aminotransferase
A2I73_RS01900	COG2608	mercury ion transmembrane transporter activity
A2I73_RS01905	COG2217	Heavy metal translocating P-type atpase
A2I73_RS01910	COG0659	secondary active sulfate transmembrane transporter activity
A2I73_RS01915	COG1136	(ABC) transporter
A2I73_RS01920	COG0577	efflux transmembrane transporter activity
A2I73_RS01925	COG1028	Short-chain dehydrogenase reductase Sdr
A2I73_RS01935	COG0471	metal ion transport
A2I73_RS01940	COG5505	Protein of unknown function (DUF819)
A2I73_RS01955	COG4336	lyase activity
A2I73_RS01970	COG1012	belongs to the aldehyde dehydrogenase family
A2I73_RS01995	COG1473	amidohydrolase
A2I73_RS02025	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A2I73_RS02030	COG3425	synthase
A2I73_RS02045	COG3386	PFAM SMP-30 Gluconolaconase
A2I73_RS02050	COG3942	CHAP domain
A2I73_RS02050	COG1388	LysM domain
A2I73_RS02055	COG1757	Na H antiporter
A2I73_RS02060	COG0583	DNA-binding transcription factor activity
A2I73_RS02065	COG1380	Effector of murein hydrolase LrgA
A2I73_RS02075	COG0028	Belongs to the TPP enzyme family
A2I73_RS02080	COG1288	antiporter activity
A2I73_RS02085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A2I73_RS02085	COG2190	(PTS) system
A2I73_RS02085	COG1263	PTS System
A2I73_RS02100	COG2515	1-aminocyclopropane-1-carboxylate deaminase
A2I73_RS02120	COG0657	acetylesterase activity
A2I73_RS02135	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A2I73_RS02145	COG2843	Capsule synthesis protein
A2I73_RS02165	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A2I73_RS02170	COG1063	alcohol dehydrogenase
A2I73_RS02175	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A2I73_RS02195	COG1129	ABC transporter
A2I73_RS02215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A2I73_RS02225	COG3764	Sortase (surface protein transpeptidase)
A2I73_RS02230	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
A2I73_RS02235	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A2I73_RS02245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A2I73_RS02250	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A2I73_RS02270	COG2249	NAD(P)H dehydrogenase (quinone) activity
A2I73_RS02275	COG0561	phosphatase activity
A2I73_RS02280	COG0778	Nitroreductase
A2I73_RS02285	COG2514	catechol 2,3-dioxygenase activity
A2I73_RS02295	COG1132	(ABC) transporter
A2I73_RS02300	COG1132	(ABC) transporter
A2I73_RS02310	COG0803	Belongs to the bacterial solute-binding protein 9 family
A2I73_RS02315	COG1012	belongs to the aldehyde dehydrogenase family
A2I73_RS02320	COG1846	Transcriptional regulator
A2I73_RS02325	COG0346	lactoylglutathione lyase activity
A2I73_RS02330	COG0346	lactoylglutathione lyase activity
A2I73_RS02335	COG0400	carboxylic ester hydrolase activity
A2I73_RS02345	COG0471	metal ion transport
A2I73_RS02350	COG3949	Membrane
A2I73_RS02360	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
A2I73_RS02365	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A2I73_RS02370	COG0586	Pfam SNARE associated Golgi protein
A2I73_RS02375	COG2271	Major facilitator Superfamily
A2I73_RS02385	COG3527	Alpha-acetolactate decarboxylase
A2I73_RS02390	COG1289	transmembrane transporter activity
A2I73_RS02405	COG4876	unkown
A2I73_RS02410	COG2357	RelA SpoT domain protein
A2I73_RS02420	COG1802	Transcriptional regulator
A2I73_RS02425	COG1070	Carbohydrate kinase
A2I73_RS02430	COG2610	gluconate transmembrane transporter activity
A2I73_RS02435	COG1028	Short-chain dehydrogenase reductase Sdr
A2I73_RS02440	COG3949	Membrane
A2I73_RS02450	COG2211	Major facilitator Superfamily
A2I73_RS02455	COG3250	beta-galactosidase activity
A2I73_RS02475	COG2211	Major facilitator Superfamily
A2I73_RS02480	COG1904	glucuronate isomerase
A2I73_RS02485	COG1312	Catalyzes the dehydration of D-mannonate
A2I73_RS02500	COG4221	oxidoreductase activity
A2I73_RS02540	COG0107	imidazoleglycerol-phosphate synthase activity
A2I73_RS02545	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A2I73_RS02550	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A2I73_RS02555	COG0131	Imidazoleglycerol-phosphate dehydratase
A2I73_RS02560	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A2I73_RS02565	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A2I73_RS02570	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A2I73_RS02580	COG3048	D-serine ammonia-lyase activity
A2I73_RS02585	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A2I73_RS02590	COG0248	Ppx GppA phosphatase
A2I73_RS02595	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
A2I73_RS02600	COG1028	Short-chain dehydrogenase reductase Sdr
A2I73_RS02605	COG1363	Peptidase, m42
A2I73_RS02615	COG0069	glutamate synthase activity
A2I73_RS02625	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A2I73_RS02630	COG0390	transport system, permease component
A2I73_RS02635	COG2814	Major facilitator Superfamily
A2I73_RS02640	COG2851	Citrate transporter
A2I73_RS02645	COG0531	amino acid
A2I73_RS02655	COG1309	transcriptional regulator
A2I73_RS02660	COG3246	L-lysine catabolic process to acetate
A2I73_RS02665	COG1250	3-hydroxyacyl-CoA dehydrogenase
A2I73_RS02680	COG1174	glycine betaine transport
A2I73_RS02690	COG1174	glycine betaine transport
A2I73_RS02700	COG1346	cytolysis
A2I73_RS02705	COG1380	Effector of murein hydrolase LrgA
A2I73_RS02710	COG3279	Response regulator of the LytR AlgR family
A2I73_RS02715	COG3275	phosphorelay sensor kinase activity
A2I73_RS02725	COG4187	Peptidase family M20/M25/M40
A2I73_RS02745	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
A2I73_RS02755	COG0706	membrane insertase activity
A2I73_RS02760	COG0025	NhaP-type Na H and K H
A2I73_RS02780	COG2814	Major facilitator Superfamily
A2I73_RS02790	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A2I73_RS02795	COG1388	LysM domain
A2I73_RS02800	COG0588	phosphoglycerate mutase activity
A2I73_RS02810	COG2814	Major facilitator Superfamily
A2I73_RS02825	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A2I73_RS02830	COG0803	Belongs to the bacterial solute-binding protein 9 family
A2I73_RS02830	COG3443	Belongs to the bacterial solute-binding protein 9 family
A2I73_RS02835	COG2353	YceI-like domain
A2I73_RS02845	COG1695	Transcriptional regulator
A2I73_RS02865	COG2723	6-phospho-beta-galactosidase activity
A2I73_RS02870	COG1263	PTS System
A2I73_RS02870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A2I73_RS02870	COG2190	(PTS) system
A2I73_RS02875	COG2188	Transcriptional regulator
A2I73_RS02880	COG2116	formate transmembrane transporter activity
A2I73_RS02885	COG0454	-acetyltransferase
A2I73_RS02900	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A2I73_RS02905	COG2146	nitrite reductase [NAD(P)H] activity
A2I73_RS02920	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A2I73_RS02925	COG1140	nitrate reductase beta subunit
A2I73_RS02935	COG2181	nitrate reductase activity
A2I73_RS02945	COG4585	Histidine kinase
A2I73_RS02955	COG2223	nitrite transmembrane transporter activity
A2I73_RS02970	COG1846	Transcriptional regulator
A2I73_RS02995	COG1263	PTS System
A2I73_RS02995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A2I73_RS03015	COG1283	sodium-dependent phosphate transmembrane transporter activity
A2I73_RS03020	COG1028	Short-chain dehydrogenase reductase Sdr
A2I73_RS03025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A2I73_RS03030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A2I73_RS03040	COG1288	antiporter activity
A2I73_RS03045	COG1349	DNA-binding transcription factor activity
A2I73_RS03050	COG1063	alcohol dehydrogenase
A2I73_RS03055	COG2376	Dihydroxyacetone kinase
A2I73_RS03065	COG0698	ribose 5-phosphate isomerase
A2I73_RS03085	COG2814	Major facilitator Superfamily
A2I73_RS03090	COG0604	alcohol dehydrogenase
A2I73_RS03110	COG1620	l-lactate permease
A2I73_RS03115	COG0438	transferase activity, transferring glycosyl groups
A2I73_RS03125	COG3850	Histidine kinase
A2I73_RS03125	COG5002	protein histidine kinase activity
A2I73_RS03130	COG0745	RESPONSE REGULATOR receiver
A2I73_RS03135	COG0577	efflux transmembrane transporter activity
A2I73_RS03140	COG1136	(ABC) transporter
A2I73_RS03155	COG4640	response to antibiotic
A2I73_RS03160	COG2814	Major facilitator Superfamily
A2I73_RS03170	COG1566	PFAM secretion protein HlyD family protein
A2I73_RS03175	COG2814	Major facilitator Superfamily
A2I73_RS03200	COG0598	Magnesium transport protein CorA
A2I73_RS03205	COG1304	FMN binding
A2I73_RS03210	COG0786	glutamate:sodium symporter activity
A2I73_RS03215	COG1757	Na H antiporter
A2I73_RS03220	COG2094	Belongs to the DNA glycosylase MPG family
A2I73_RS03225	COG3152	Membrane
A2I73_RS03230	COG1069	ribulokinase activity
A2I73_RS03235	COG4152	abc transporter atp-binding protein
A2I73_RS03240	COG1668	transmembrane transport
A2I73_RS03245	COG2017	converts alpha-aldose to the beta-anomer
A2I73_RS03250	COG2258	MOSC domain
A2I73_RS03255	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A2I73_RS03260	COG1266	CAAX protease self-immunity
A2I73_RS03265	COG0010	Belongs to the arginase family
A2I73_RS03270	COG0583	DNA-binding transcription factor activity
A2I73_RS03275	COG3314	Sporulation integral membrane protein YlbJ
A2I73_RS03280	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A2I73_RS03285	COG1228	amidohydrolase
A2I73_RS03290	COG0659	secondary active sulfate transmembrane transporter activity
A2I73_RS03295	COG1473	amidohydrolase
A2I73_RS03300	COG1028	Short-chain dehydrogenase reductase Sdr
A2I73_RS03305	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A2I73_RS03325	COG1263	PTS System
A2I73_RS03325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A2I73_RS03335	COG0385	Bile acid
A2I73_RS03340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A2I73_RS03365	COG1113	amino acid transport
A2I73_RS03370	COG1785	Belongs to the alkaline phosphatase family
A2I73_RS03380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A2I73_RS03380	COG1263	PTS System
A2I73_RS03385	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A2I73_RS03410	COG1316	TRANSCRIPTIONal
A2I73_RS03415	COG3383	formate dehydrogenase (NAD+) activity
A2I73_RS03445	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A2I73_RS03450	COG2076	Multidrug Resistance protein
A2I73_RS03455	COG2076	Multidrug Resistance protein
A2I73_RS03460	COG3942	CHAP domain
A2I73_RS03475	COG1757	Na H antiporter
A2I73_RS03480	COG3942	CHAP domain
A2I73_RS03505	COG0765	amino acid transport
A2I73_RS03510	COG0765	amino acid transport
A2I73_RS03515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A2I73_RS03520	COG1126	abc transporter atp-binding protein
A2I73_RS03530	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A2I73_RS03535	COG1268	BioY protein
A2I73_RS03545	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A2I73_RS03550	COG1609	Transcriptional regulator
A2I73_RS03555	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A2I73_RS03560	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A2I73_RS03565	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
A2I73_RS03570	COG0725	ABC transporter, periplasmic molybdate-binding protein
A2I73_RS03575	COG4149	molybdate abc transporter
A2I73_RS03580	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A2I73_RS03585	COG1510	regulation of RNA biosynthetic process
A2I73_RS03590	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A2I73_RS03595	COG0521	Mo-molybdopterin cofactor biosynthetic process
A2I73_RS03600	COG0315	cyclic pyranopterin monophosphate synthase activity
A2I73_RS03625	COG0746	molybdenum cofactor guanylyltransferase activity
A2I73_RS03630	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A2I73_RS03655	COG2348	transferase activity, transferring amino-acyl groups
A2I73_RS03660	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A2I73_RS03685	COG4975	Glucose uptake
A2I73_RS03695	COG0551	DNA topoisomerase type I activity
A2I73_RS03695	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A2I73_RS03700	COG2252	PERMEase
A2I73_RS03710	COG0051	transcription antitermination factor activity, RNA binding
A2I73_RS03715	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A2I73_RS03720	COG0088	Forms part of the polypeptide exit tunnel
A2I73_RS03725	COG0089	rRNA binding
A2I73_RS03730	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A2I73_RS03735	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A2I73_RS03740	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A2I73_RS03745	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A2I73_RS03750	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A2I73_RS03755	COG0255	Belongs to the universal ribosomal protein uL29 family
A2I73_RS03760	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A2I73_RS03765	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A2I73_RS03770	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A2I73_RS03775	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A2I73_RS03780	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A2I73_RS03785	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A2I73_RS03790	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A2I73_RS03795	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A2I73_RS03800	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A2I73_RS03805	COG1841	ribosomal large subunit assembly
A2I73_RS03810	COG0200	Binds to the 23S rRNA
A2I73_RS03815	COG0201	protein transport
A2I73_RS03830	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A2I73_RS03835	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A2I73_RS03840	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A2I73_RS03845	COG0202	RNA polymerase activity
A2I73_RS03850	COG0203	ribosomal protein L17
A2I73_RS03855	COG1122	ATPase activity
A2I73_RS03860	COG1122	ATPase activity
A2I73_RS03870	COG0101	tRNA pseudouridine synthase activity
A2I73_RS03875	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A2I73_RS03880	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A2I73_RS03890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A2I73_RS03895	COG2130	NADP-dependent
A2I73_RS03900	COG0604	alcohol dehydrogenase
A2I73_RS03905	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A2I73_RS03920	COG1302	Protein conserved in bacteria
A2I73_RS03925	COG4264	IucA IucC family
A2I73_RS03930	COG2814	Major facilitator Superfamily
A2I73_RS03935	COG4264	IucA IucC family
A2I73_RS03940	COG3457	Alanine racemase
A2I73_RS03945	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A2I73_RS03950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A2I73_RS03955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A2I73_RS03960	COG3314	Sporulation integral membrane protein YlbJ
A2I73_RS03965	COG2329	Antibiotic biosynthesis monooxygenase
A2I73_RS03975	COG1988	membrane-bound metal-dependent
A2I73_RS03980	COG4284	Utp--glucose-1-phosphate uridylyltransferase
A2I73_RS03985	COG1272	protein, Hemolysin III
A2I73_RS04000	COG0489	protein tyrosine kinase activity
A2I73_RS04055	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A2I73_RS04065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A2I73_RS04070	COG0246	Mannitol dehydrogenase
A2I73_RS04080	COG3711	transcriptional antiterminator
A2I73_RS04085	COG2213	PTS system mannitol-specific
A2I73_RS04100	COG1119	ATPase activity
A2I73_RS04125	COG0640	Transcriptional regulator
A2I73_RS04130	COG0702	epimerase
A2I73_RS04135	COG2186	Transcriptional regulator
A2I73_RS04140	COG1482	cell wall glycoprotein biosynthetic process
A2I73_RS04150	COG2855	membrane
A2I73_RS04165	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A2I73_RS04170	COG0783	Belongs to the Dps family
A2I73_RS04175	COG0813	purine-nucleoside phosphorylase activity
A2I73_RS04180	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A2I73_RS04185	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A2I73_RS04190	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A2I73_RS04200	COG1854	S-ribosylhomocysteine lyase activity
A2I73_RS04220	COG5146	pantothenate kinase activity
A2I73_RS04225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A2I73_RS04235	COG0504	CTP synthase activity
A2I73_RS04240	COG0191	fructose-bisphosphate aldolase activity
A2I73_RS04245	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A2I73_RS04255	COG1012	belongs to the aldehyde dehydrogenase family
A2I73_RS04260	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A2I73_RS04265	COG0254	rRNA binding
A2I73_RS04270	COG1435	thymidine kinase activity
A2I73_RS04275	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A2I73_RS04280	COG2890	protein-(glutamine-N5) methyltransferase activity
A2I73_RS04285	COG0009	L-threonylcarbamoyladenylate synthase
A2I73_RS04290	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A2I73_RS04295	COG4475	Protein of unknown function (DUF436)
A2I73_RS04300	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A2I73_RS04305	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A2I73_RS04310	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A2I73_RS04320	COG0356	it plays a direct role in the translocation of protons across the membrane
A2I73_RS04325	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A2I73_RS04330	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A2I73_RS04335	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A2I73_RS04340	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A2I73_RS04345	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A2I73_RS04350	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A2I73_RS04355	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A2I73_RS04365	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A2I73_RS04370	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A2I73_RS04380	COG0629	single-stranded DNA binding
A2I73_RS04385	COG1388	LysM domain
A2I73_RS04390	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A2I73_RS04400	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A2I73_RS04405	COG0352	thiamine-phosphate diphosphorylase activity
A2I73_RS04410	COG0706	membrane insertase activity
A2I73_RS04415	COG1418	mRNA catabolic process
A2I73_RS04425	COG1937	Protein conserved in bacteria
A2I73_RS04440	COG0772	Belongs to the SEDS family
A2I73_RS04445	COG1181	Belongs to the D-alanine--D-alanine ligase family
A2I73_RS04450	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A2I73_RS04455	COG0513	Belongs to the DEAD box helicase family
A2I73_RS04465	COG3428	Bacterial PH domain
A2I73_RS04480	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A2I73_RS04490	COG2337	Toxic component of a toxin-antitoxin (TA) module
A2I73_RS04495	COG2208	phosphoserine phosphatase activity
A2I73_RS04510	COG1191	sigma factor activity
A2I73_RS04515	COG2183	response to ionizing radiation
A2I73_RS04520	COG3091	SprT-like family
A2I73_RS04550	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A2I73_RS04555	COG0066	3-isopropylmalate dehydratase activity
A2I73_RS04560	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A2I73_RS04565	COG0473	3-isopropylmalate dehydrogenase activity
A2I73_RS04570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A2I73_RS04575	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A2I73_RS04580	COG0440	acetolactate synthase activity
A2I73_RS04585	COG0028	Belongs to the TPP enzyme family
A2I73_RS04590	COG0129	dihydroxy-acid dehydratase activity
A2I73_RS04595	COG0802	atpase or kinase
A2I73_RS04600	COG1214	PFAM Peptidase M22, glycoprotease
A2I73_RS04605	COG0456	acetyltransferase
A2I73_RS04610	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A2I73_RS04620	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A2I73_RS04625	COG0488	(ABC) transporter
A2I73_RS04630	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A2I73_RS04635	COG2391	methyltransferase activity
A2I73_RS04640	COG0425	Belongs to the sulfur carrier protein TusA family
A2I73_RS04645	COG1609	Transcriptional regulator
A2I73_RS04655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A2I73_RS04660	COG3279	Response regulator of the LytR AlgR family
A2I73_RS04665	COG3290	protein histidine kinase activity
A2I73_RS04675	COG4512	PFAM Accessory gene regulator B
A2I73_RS04680	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A2I73_RS04700	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A2I73_RS04705	COG0459	protein refolding
A2I73_RS04730	COG1725	Transcriptional regulator
A2I73_RS04745	COG1131	(ABC) transporter
A2I73_RS04790	COG2706	6-phosphogluconolactonase activity
A2I73_RS04795	COG1012	belongs to the aldehyde dehydrogenase family
A2I73_RS04800	COG1227	inorganic diphosphatase activity
A2I73_RS04805	COG1335	isochorismatase
A2I73_RS04815	COG0471	metal ion transport
A2I73_RS04820	COG0077	Prephenate dehydratase
A2I73_RS04830	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A2I73_RS04835	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A2I73_RS04840	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
A2I73_RS04850	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A2I73_RS04855	COG4496	protein, YerC YecD
A2I73_RS04860	COG1876	peptidase activity
A2I73_RS04865	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
A2I73_RS04875	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A2I73_RS04880	COG4851	CamS sex pheromone cAM373 precursor
A2I73_RS04885	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A2I73_RS04890	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A2I73_RS04895	COG0154	amidase activity
A2I73_RS04900	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A2I73_RS04905	COG1597	lipid kinase activity
A2I73_RS04910	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A2I73_RS04920	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A2I73_RS04930	COG1528	Iron-storage protein
A2I73_RS04945	COG4129	membrane
A2I73_RS04950	COG0024	Methionine aminopeptidase
A2I73_RS04965	COG4585	Histidine kinase
A2I73_RS04970	COG2197	response regulator
A2I73_RS04975	COG1295	ribonuclease BN
A2I73_RS04985	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A2I73_RS04990	COG4840	Belongs to the UPF0435 family
A2I73_RS04995	COG2309	aminopeptidase activity
A2I73_RS05000	COG1607	acyl-coa hydrolase
A2I73_RS05005	COG0535	radical SAM domain protein
A2I73_RS05015	COG0693	protein deglycase activity
A2I73_RS05020	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A2I73_RS05025	COG2137	regulation of response to DNA damage stimulus
A2I73_RS05035	COG1134	teichoic acid transport
A2I73_RS05045	COG1988	membrane-bound metal-dependent
A2I73_RS05055	COG3557	Belongs to the UPF0374 family
A2I73_RS05065	COG4129	membrane
A2I73_RS05070	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A2I73_RS05075	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A2I73_RS05080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A2I73_RS05085	COG0735	belongs to the Fur family
A2I73_RS05235	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A2I73_RS05250	COG0765	amino acid transport
A2I73_RS05255	COG1126	abc transporter atp-binding protein
A2I73_RS05260	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A2I73_RS05270	COG0363	glucosamine-6-phosphate deaminase activity
A2I73_RS05285	COG0114	fumarate hydratase activity
A2I73_RS05290	COG0564	pseudouridine synthase activity
A2I73_RS05295	COG4585	Histidine kinase
A2I73_RS05295	COG2203	Gaf domain
A2I73_RS05300	COG2197	response regulator
A2I73_RS05315	COG1316	TRANSCRIPTIONal
A2I73_RS05320	COG0730	response to heat
A2I73_RS05330	COG1682	transport, permease protein
A2I73_RS05345	COG0788	formyltetrahydrofolate deformylase activity
A2I73_RS05355	COG4399	Belongs to the UPF0754 family
A2I73_RS05360	COG3679	Belongs to the UPF0342 family
A2I73_RS05365	COG0420	3'-5' exonuclease activity
A2I73_RS05370	COG4717	serine-type aminopeptidase activity
A2I73_RS05375	COG3481	metal-dependent phosphohydrolase, HD sub domain
A2I73_RS05380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A2I73_RS05395	COG0537	adenosine 5'-monophosphoramidase activity
A2I73_RS05400	COG1131	(ABC) transporter
A2I73_RS05405	COG4473	ABC transporter
A2I73_RS05415	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A2I73_RS05420	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A2I73_RS05425	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
A2I73_RS05430	COG3545	Serine hydrolase
A2I73_RS05520	COG4824	toxin secretion phage lysis holin
A2I73_RS05540	COG1388	LysM domain
A2I73_RS05540	COG5632	N-Acetylmuramoyl-L-alanine amidase
A2I73_RS05565	COG1028	Short-chain dehydrogenase reductase Sdr
A2I73_RS05585	COG0300	oxidoreductase activity
A2I73_RS05615	COG0318	PFAM AMP-dependent synthetase and ligase
A2I73_RS05625	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A2I73_RS05635	COG1506	peptidase
A2I73_RS05640	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A2I73_RS05645	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A2I73_RS05655	COG0656	L-ascorbic acid biosynthetic process
A2I73_RS05660	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A2I73_RS05665	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A2I73_RS05675	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A2I73_RS05695	COG1595	DNA-templated transcription, initiation
A2I73_RS05705	COG5632	N-Acetylmuramoyl-L-alanine amidase
A2I73_RS05705	COG3266	domain, Protein
A2I73_RS05705	COG4193	domain, Protein
A2I73_RS05720	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A2I73_RS05720	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A2I73_RS05725	COG0307	riboflavin synthase, alpha
A2I73_RS05730	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A2I73_RS05730	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A2I73_RS05735	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A2I73_RS05745	COG2267	carboxylic ester hydrolase activity
A2I73_RS05750	COG0039	L-malate dehydrogenase activity
A2I73_RS05760	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A2I73_RS05765	COG1242	4 iron, 4 sulfur cluster binding
A2I73_RS05770	COG2814	Major facilitator Superfamily
A2I73_RS05775	COG0495	leucyl-tRNA aminoacylation
A2I73_RS05785	COG2081	HI0933 family
A2I73_RS05790	COG2244	polysaccharide biosynthetic process
A2I73_RS05795	COG1187	pseudouridine synthase activity
A2I73_RS05805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A2I73_RS05810	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A2I73_RS05815	COG0510	thiamine kinase activity
A2I73_RS05820	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A2I73_RS05835	COG1363	Peptidase, m42
A2I73_RS05840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A2I73_RS05845	COG4848	Belongs to the UPF0354 family
A2I73_RS05850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A2I73_RS05855	COG1674	ftsk spoiiie
A2I73_RS05860	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A2I73_RS05865	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
A2I73_RS05875	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A2I73_RS05875	COG1605	Chorismate mutase
A2I73_RS05880	COG1609	Transcriptional regulator
A2I73_RS05885	COG0123	including yeast histone deacetylase and acetoin utilization protein
A2I73_RS05890	COG0454	-acetyltransferase
A2I73_RS05895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A2I73_RS05910	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A2I73_RS05915	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A2I73_RS05920	COG0204	Acyl-transferase
A2I73_RS05935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A2I73_RS05940	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A2I73_RS05945	COG1764	response to oxidative stress
A2I73_RS05950	COG0584	glycerophosphoryl diester phosphodiesterase
A2I73_RS05955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A2I73_RS05960	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A2I73_RS05965	COG1956	GAF domain-containing protein
A2I73_RS05970	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
A2I73_RS05975	COG1104	cysteine desulfurase activity
A2I73_RS05980	COG0301	tRNA thio-modification
A2I73_RS05990	COG0616	signal peptide processing
A2I73_RS05995	COG1714	RDD family
A2I73_RS06000	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A2I73_RS06005	COG0827	DNA restriction-modification system
A2I73_RS06010	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A2I73_RS06020	COG0589	response to stress
A2I73_RS06025	COG0686	Belongs to the AlaDH PNT family
A2I73_RS06030	COG3142	Participates in the control of copper homeostasis
A2I73_RS06035	COG0006	proline dipeptidase activity
A2I73_RS06040	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A2I73_RS06050	COG4109	DRTGG domain
A2I73_RS06055	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A2I73_RS06060	COG0587	DNA-directed DNA polymerase activity
A2I73_RS06065	COG0281	malic enzyme
A2I73_RS06070	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A2I73_RS06075	COG0825	malonyl-CoA metabolic process
A2I73_RS06080	COG0205	6-phosphofructokinase activity
A2I73_RS06085	COG0469	pyruvate kinase activity
A2I73_RS06090	COG1113	amino acid transport
A2I73_RS06095	COG0372	Belongs to the citrate synthase family
A2I73_RS06100	COG0538	isocitrate dehydrogenase activity
A2I73_RS06105	COG0745	RESPONSE REGULATOR receiver
A2I73_RS06110	COG5002	protein histidine kinase activity
A2I73_RS06115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A2I73_RS06115	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A2I73_RS06125	COG0237	dephospho-CoA kinase activity
A2I73_RS06130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A2I73_RS06135	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A2I73_RS06145	COG1484	DNA-dependent DNA replication
A2I73_RS06150	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A2I73_RS06155	COG0833	amino acid
A2I73_RS06160	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A2I73_RS06165	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A2I73_RS06170	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A2I73_RS06175	COG4112	unkown
A2I73_RS06185	COG0544	peptidyl-prolyl cis-trans isomerase activity
A2I73_RS06190	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A2I73_RS06195	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A2I73_RS06200	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A2I73_RS06205	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A2I73_RS06210	COG0181	hydroxymethylbilane synthase activity
A2I73_RS06220	COG0113	porphobilinogen synthase activity
A2I73_RS06225	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A2I73_RS06235	COG2818	Glycosylase
A2I73_RS06240	COG0525	valine-tRNA ligase activity
A2I73_RS06245	COG0285	dihydrofolate synthase activity
A2I73_RS06260	COG2003	Belongs to the UPF0758 family
A2I73_RS06295	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A2I73_RS06300	COG2868	ribosomal protein
A2I73_RS06305	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A2I73_RS06310	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A2I73_RS06315	COG4492	Belongs to the UPF0735 family
A2I73_RS06320	COG0632	four-way junction helicase activity
A2I73_RS06325	COG2255	four-way junction helicase activity
A2I73_RS06330	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A2I73_RS06335	COG0343	queuine tRNA-ribosyltransferase activity
A2I73_RS06340	COG1862	Preprotein translocase
A2I73_RS06345	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A2I73_RS06345	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A2I73_RS06350	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A2I73_RS06350	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A2I73_RS06360	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A2I73_RS06365	COG1490	D-aminoacyl-tRNA deacylase activity
A2I73_RS06370	COG0860	N-Acetylmuramoyl-L-alanine amidase
A2I73_RS06375	COG0124	histidyl-tRNA synthetase
A2I73_RS06380	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A2I73_RS06390	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A2I73_RS06395	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A2I73_RS06400	COG1959	2 iron, 2 sulfur cluster binding
A2I73_RS06415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A2I73_RS06420	COG0488	(ABC) transporter
A2I73_RS06425	COG1104	cysteine desulfurase activity
A2I73_RS06430	COG0482	sulfurtransferase activity
A2I73_RS06440	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A2I73_RS06445	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A2I73_RS06450	COG4472	Bacterial protein of unknown function (DUF965)
A2I73_RS06455	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A2I73_RS06460	COG3906	Belongs to the UPF0473 family
A2I73_RS06465	COG4122	O-methyltransferase activity
A2I73_RS06470	COG0826	peptidase U32
A2I73_RS06475	COG0826	peptidase U32
A2I73_RS06480	COG0572	uridine kinase
A2I73_RS06485	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A2I73_RS06490	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A2I73_RS06495	COG1984	allophanate hydrolase subunit 2
A2I73_RS06500	COG0511	ligase activity, forming carbon-carbon bonds
A2I73_RS06505	COG0439	Biotin carboxylase
A2I73_RS06510	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A2I73_RS06515	COG1914	H( )-stimulated, divalent metal cation uptake system
A2I73_RS06520	COG0730	response to heat
A2I73_RS06525	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A2I73_RS06530	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A2I73_RS06535	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A2I73_RS06540	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A2I73_RS06545	COG1534	Rna-binding protein
A2I73_RS06550	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A2I73_RS06555	COG1713	HD superfamily hydrolase involved in NAD metabolism
A2I73_RS06560	COG0799	negative regulation of ribosome biogenesis
A2I73_RS06565	COG2226	methyltransferase
A2I73_RS06570	COG1555	photosystem II stabilization
A2I73_RS06570	COG1596	polysaccharide export
A2I73_RS06575	COG2131	deaminase
A2I73_RS06585	COG2333	competence protein COMEC
A2I73_RS06585	COG0658	competence protein
A2I73_RS06590	COG1466	dna polymerase III delta subunit
A2I73_RS06595	COG0268	Binds directly to 16S ribosomal RNA
A2I73_RS06600	COG0481	GTPase activity
A2I73_RS06605	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A2I73_RS06610	COG1420	regulation of RNA biosynthetic process
A2I73_RS06615	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A2I73_RS06620	COG0443	Heat shock 70 kDa protein
A2I73_RS06625	COG0484	heat shock protein binding
A2I73_RS06630	COG2264	protein methyltransferase activity
A2I73_RS06635	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A2I73_RS06640	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A2I73_RS06645	COG1030	water channel activity
A2I73_RS06650	COG4864	UPF0365 protein
A2I73_RS06660	COG1702	phosphate starvation-inducible protein PhoH
A2I73_RS06665	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A2I73_RS06670	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A2I73_RS06675	COG0295	cytidine deaminase activity
A2I73_RS06680	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A2I73_RS06685	COG1381	Involved in DNA repair and RecF pathway recombination
A2I73_RS06690	COG0423	glycine-tRNA ligase activity
A2I73_RS06695	COG0517	IMP dehydrogenase activity
A2I73_RS06700	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A2I73_RS06710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A2I73_RS06715	COG2384	SAM-dependent methyltransferase
A2I73_RS06725	COG0513	Belongs to the DEAD box helicase family
A2I73_RS06730	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A2I73_RS06735	COG1121	(ABC) transporter
A2I73_RS06740	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A2I73_RS06750	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A2I73_RS06755	COG0768	penicillin binding
A2I73_RS06760	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A2I73_RS06765	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A2I73_RS06770	COG0457	Tetratricopeptide repeat
A2I73_RS06770	COG0705	Rhomboid family
A2I73_RS06775	COG4483	Protein conserved in bacteria
A2I73_RS06780	COG1940	carbohydrate kinase activity
A2I73_RS06785	COG0011	TIGRFAM Protein of
A2I73_RS06790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A2I73_RS06795	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A2I73_RS06825	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A2I73_RS06830	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A2I73_RS06835	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A2I73_RS06840	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A2I73_RS06845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A2I73_RS06850	COG0095	Lipoate-protein ligase
A2I73_RS06865	COG0006	proline dipeptidase activity
A2I73_RS06870	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A2I73_RS06875	COG0511	ligase activity, forming carbon-carbon bonds
A2I73_RS06880	COG0439	Biotin carboxylase
A2I73_RS06885	COG1302	Protein conserved in bacteria
A2I73_RS06890	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A2I73_RS06895	COG1570	exodeoxyribonuclease VII activity
A2I73_RS06900	COG1722	exodeoxyribonuclease VII activity
A2I73_RS06910	COG1438	arginine binding
A2I73_RS06915	COG0497	DNA recombination
A2I73_RS06920	COG0280	phosphate acetyltransferase
A2I73_RS06925	COG3426	butyrate kinase activity
A2I73_RS06930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A2I73_RS06935	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A2I73_RS06940	COG0022	dehydrogenase e1 component
A2I73_RS06945	COG0508	dehydrogenase complex catalyzes the overall conversion of
A2I73_RS06955	COG4129	membrane
A2I73_RS06965	COG2195	Cleaves the N-terminal amino acid of tripeptides
A2I73_RS06975	COG1609	Transcriptional regulator
A2I73_RS06980	COG0366	Alpha amylase catalytic
A2I73_RS06990	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A2I73_RS06995	COG1234	tRNA 3'-trailer cleavage
A2I73_RS07000	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A2I73_RS07010	COG0667	Aldo Keto reductase
A2I73_RS07015	COG0494	nUDIX hydrolase
A2I73_RS07020	COG0735	belongs to the Fur family
A2I73_RS07025	COG4974	Belongs to the 'phage' integrase family
A2I73_RS07035	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A2I73_RS07040	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A2I73_RS07045	COG1187	pseudouridine synthase activity
A2I73_RS07050	COG0745	RESPONSE REGULATOR receiver
A2I73_RS07065	COG1141	Ferredoxin
A2I73_RS07075	COG0514	ATP-dependent DNA helicase (RecQ)
A2I73_RS07080	COG1388	LysM domain
A2I73_RS07085	COG0492	ferredoxin-NADP+ reductase activity
A2I73_RS07095	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A2I73_RS07100	COG0539	negative regulation of cytoplasmic translation
A2I73_RS07105	COG1160	GTP binding
A2I73_RS07110	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A2I73_RS07125	COG2226	methyltransferase
A2I73_RS07130	COG0142	geranyltranstransferase activity
A2I73_RS07135	COG0105	UTP biosynthetic process
A2I73_RS07140	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A2I73_RS07145	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A2I73_RS07150	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A2I73_RS07160	COG5582	Belongs to the UPF0302 family
A2I73_RS07165	COG4347	Protein of unknown function (DUF1405)
A2I73_RS07170	COG2738	Putative neutral zinc metallopeptidase
A2I73_RS07175	COG1694	Mazg nucleotide pyrophosphohydrolase
A2I73_RS07180	COG0438	transferase activity, transferring glycosyl groups
A2I73_RS07185	COG0617	tRNA 3'-terminal CCA addition
A2I73_RS07195	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A2I73_RS07195	COG1199	ATP-dependent helicase activity
A2I73_RS07200	COG0017	Asparaginyl-tRNA synthetase
A2I73_RS07205	COG3935	DnaD domain protein
A2I73_RS07210	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A2I73_RS07220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A2I73_RS07220	COG4499	WXG100 protein secretion system (Wss), protein YukC
A2I73_RS07225	COG3331	DNA recombination
A2I73_RS07235	COG4474	Belongs to the UPF0398 family
A2I73_RS07250	COG0116	Belongs to the methyltransferase superfamily
A2I73_RS07255	COG2962	Rard protein
A2I73_RS07265	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A2I73_RS07270	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A2I73_RS07280	COG3545	Serine hydrolase
A2I73_RS07285	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A2I73_RS07295	COG1413	lyase activity
A2I73_RS07300	COG1413	lyase activity
A2I73_RS07310	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A2I73_RS07330	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A2I73_RS07340	COG4479	Belongs to the UPF0346 family
A2I73_RS07345	COG0793	Belongs to the peptidase S41A family
A2I73_RS07355	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A2I73_RS07360	COG0671	phosphoesterase, PA-phosphatase related
A2I73_RS07365	COG0745	RESPONSE REGULATOR receiver
A2I73_RS07370	COG5002	protein histidine kinase activity
A2I73_RS07375	COG0567	Dehydrogenase, E1 component
A2I73_RS07380	COG0508	dehydrogenase complex catalyzes the overall conversion of
A2I73_RS07390	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A2I73_RS07400	COG1917	Cupin 2, conserved barrel domain protein
A2I73_RS07400	COG2207	Transcriptional regulator
A2I73_RS07425	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A2I73_RS07430	COG1121	(ABC) transporter
A2I73_RS07455	COG0714	Associated with various cellular activities
A2I73_RS07460	COG4548	von Willebrand factor, type A
A2I73_RS07465	COG1114	Component of the transport system for branched-chain amino acids
A2I73_RS07470	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A2I73_RS07475	COG3853	Toxic anion resistance protein (TelA)
A2I73_RS07485	COG1254	Belongs to the acylphosphatase family
A2I73_RS07495	COG1278	Cold shock
A2I73_RS07510	COG1473	amidohydrolase
A2I73_RS07520	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A2I73_RS07525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A2I73_RS07530	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A2I73_RS07535	COG0527	aspartate kinase activity
A2I73_RS07545	COG0488	(ABC) transporter
A2I73_RS07550	COG2996	Protein conserved in bacteria
A2I73_RS07555	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A2I73_RS07560	COG0573	inorganic phosphate transmembrane transporter activity
A2I73_RS07565	COG0581	inorganic phosphate transmembrane transporter activity
A2I73_RS07570	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A2I73_RS07575	COG0704	Plays a role in the regulation of phosphate uptake
A2I73_RS07580	COG1164	Oligoendopeptidase f
A2I73_RS07590	COG4607	ABC-type enterochelin transport system periplasmic component
A2I73_RS07605	COG2348	transferase activity, transferring amino-acyl groups
A2I73_RS07615	COG0159	tryptophan synthase activity
A2I73_RS07620	COG0133	tryptophan synthase activity
A2I73_RS07630	COG0134	indole-3-glycerol-phosphate synthase activity
A2I73_RS07635	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A2I73_RS07640	COG0512	Glutamine amidotransferase of anthranilate synthase
A2I73_RS07645	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A2I73_RS07660	COG0438	transferase activity, transferring glycosyl groups
A2I73_RS07665	COG0584	glycerophosphoryl diester phosphodiesterase
A2I73_RS07675	COG1363	Peptidase, m42
A2I73_RS07685	COG0287	Prephenate dehydrogenase
A2I73_RS07690	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A2I73_RS07695	COG1942	4-Oxalocrotonate Tautomerase
A2I73_RS07710	COG1879	ABC-type sugar transport system periplasmic component
A2I73_RS07715	COG1172	Belongs to the binding-protein-dependent transport system permease family
A2I73_RS07720	COG1129	ABC transporter
A2I73_RS07725	COG1869	D-ribose catabolic process
A2I73_RS07730	COG1609	Transcriptional regulator
A2I73_RS07740	COG0392	lysyltransferase activity
A2I73_RS07740	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A2I73_RS07745	COG0628	permease
A2I73_RS07755	COG3711	transcriptional antiterminator
A2I73_RS07760	COG1115	amino acid carrier protein
A2I73_RS07765	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A2I73_RS07775	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A2I73_RS07780	COG4841	protein insertion into membrane
A2I73_RS07785	COG0824	Thioesterase
A2I73_RS07790	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A2I73_RS07795	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A2I73_RS07800	COG1970	mechanosensitive ion channel activity
A2I73_RS07805	COG0419	ATPase involved in DNA repair
A2I73_RS07810	COG0420	3'-5' exonuclease activity
A2I73_RS07815	COG4846	Membrane protein involved in cytochrome C biogenesis
A2I73_RS07825	COG3763	UPF0154 protein
A2I73_RS07845	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A2I73_RS07855	COG0516	GMP reductase activity
A2I73_RS07860	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A2I73_RS07865	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A2I73_RS07870	COG0753	catalase activity
A2I73_RS07875	COG0833	amino acid
A2I73_RS07885	COG0561	phosphatase activity
A2I73_RS07890	COG0083	homoserine kinase activity
A2I73_RS07895	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A2I73_RS07900	COG0460	homoserine dehydrogenase
A2I73_RS07905	COG0527	aspartate kinase activity
A2I73_RS07940	COG2808	Putative FMN-binding domain
A2I73_RS07945	COG1764	response to oxidative stress
A2I73_RS07955	COG0789	Transcriptional regulator
A2I73_RS07960	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
A2I73_RS07965	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A2I73_RS07970	COG0386	Belongs to the glutathione peroxidase family
A2I73_RS07975	COG1923	regulation of RNA biosynthetic process
A2I73_RS07980	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A2I73_RS07990	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A2I73_RS07995	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A2I73_RS08000	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A2I73_RS08015	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A2I73_RS08020	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A2I73_RS08030	COG4550	Control of competence regulator ComK, YlbF/YmcA
A2I73_RS08035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A2I73_RS08050	COG1959	2 iron, 2 sulfur cluster binding
A2I73_RS08055	COG4195	phage-related replication protein
A2I73_RS08065	COG1013	pyruvate-flavodoxin oxidoreductase activity
A2I73_RS08070	COG0674	pyruvate-flavodoxin oxidoreductase activity
A2I73_RS08070	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A2I73_RS08075	COG1692	metallophosphoesterase
A2I73_RS08085	COG1418	mRNA catabolic process
A2I73_RS08090	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A2I73_RS08115	COG0300	oxidoreductase activity
A2I73_RS08120	COG0612	Peptidase, M16
A2I73_RS08125	COG0612	Peptidase, M16
A2I73_RS08130	COG2188	Transcriptional regulator
A2I73_RS08135	COG1674	ftsk spoiiie
A2I73_RS08140	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A2I73_RS08145	COG1185	polyribonucleotide nucleotidyltransferase activity
A2I73_RS08150	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A2I73_RS08155	COG0196	riboflavin kinase activity
A2I73_RS08160	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A2I73_RS08165	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A2I73_RS08180	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A2I73_RS08185	COG1358	cellular component organization or biogenesis
A2I73_RS08190	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A2I73_RS08195	COG0195	Participates in both transcription termination and antitermination
A2I73_RS08200	COG0779	Required for maturation of 30S ribosomal subunits
A2I73_RS08205	COG2176	DNA-directed DNA polymerase activity
A2I73_RS08210	COG0442	prolyl-tRNA aminoacylation
A2I73_RS08220	COG4589	Belongs to the CDS family
A2I73_RS08225	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A2I73_RS08230	COG0233	cytoplasmic translational termination
A2I73_RS08235	COG0528	UMP kinase activity
A2I73_RS08240	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A2I73_RS08245	COG0052	Belongs to the universal ribosomal protein uS2 family
A2I73_RS08250	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A2I73_RS08255	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A2I73_RS08260	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A2I73_RS08265	COG4974	Belongs to the 'phage' integrase family
A2I73_RS08270	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A2I73_RS08275	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A2I73_RS08280	COG0758	DNA mediated transformation
A2I73_RS08290	COG0045	succinate-CoA ligase (ADP-forming) activity
A2I73_RS08295	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A2I73_RS08305	COG4485	Bacterial membrane protein, YfhO
A2I73_RS08315	COG0335	large ribosomal subunit rRNA binding
A2I73_RS08320	COG0336	Belongs to the RNA methyltransferase TrmD family
A2I73_RS08325	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A2I73_RS08330	COG0228	four-way junction DNA binding
A2I73_RS08335	COG1028	Short-chain dehydrogenase reductase Sdr
A2I73_RS08340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A2I73_RS08345	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A2I73_RS08350	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
A2I73_RS08355	COG0552	protein localization to endoplasmic reticulum
A2I73_RS08360	COG1196	nuclear chromosome segregation
A2I73_RS08365	COG0571	ribonuclease III activity
A2I73_RS08370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A2I73_RS08385	COG0416	fatty acid biosynthetic process
A2I73_RS08390	COG1349	DNA-binding transcription factor activity
A2I73_RS08400	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A2I73_RS08405	COG1760	l-serine dehydratase
A2I73_RS08410	COG1760	l-serine dehydratase
A2I73_RS08415	COG1461	Dihydroxyacetone kinase
A2I73_RS08420	COG1302	Protein conserved in bacteria
A2I73_RS08425	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A2I73_RS08430	COG1564	THIamine pyrophosphokinase
A2I73_RS08435	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A2I73_RS08440	COG1162	GTPase activity
A2I73_RS08455	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A2I73_RS08460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A2I73_RS08460	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A2I73_RS08465	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A2I73_RS08470	COG0242	peptide deformylase activity
A2I73_RS08485	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A2I73_RS08490	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A2I73_RS08495	COG1758	RNA polymerase activity
A2I73_RS08500	COG0194	GDP metabolic process
A2I73_RS08505	COG1293	RNA-binding protein homologous to eukaryotic snRNP
A2I73_RS08515	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A2I73_RS08525	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A2I73_RS08530	COG0284	orotidine-5'-phosphate decarboxylase activity
A2I73_RS08535	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A2I73_RS08540	COG0505	Belongs to the CarA family
A2I73_RS08550	COG0540	Belongs to the ATCase OTCase family
A2I73_RS08560	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A2I73_RS08565	COG0564	pseudouridine synthase activity
A2I73_RS08570	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A2I73_RS08580	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A2I73_RS08585	COG3599	regulation of cell shape
A2I73_RS08595	COG0762	integral membrane protein
A2I73_RS08600	COG1799	cell septum assembly
A2I73_RS08605	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A2I73_RS08610	COG1496	oxidoreductase activity
A2I73_RS08615	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A2I73_RS08620	COG0849	cell division
A2I73_RS08630	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A2I73_RS08635	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A2I73_RS08640	COG0768	penicillin binding
A2I73_RS08645	COG4839	cell division protein FtsL
A2I73_RS08650	COG0275	rRNA processing
A2I73_RS08655	COG2001	Belongs to the MraZ family
A2I73_RS08660	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
A2I73_RS08665	COG0454	-acetyltransferase
A2I73_RS08670	COG1011	Hydrolase
A2I73_RS08740	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A2I73_RS08745	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A2I73_RS08750	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A2I73_RS08755	COG1053	succinate dehydrogenase
A2I73_RS08760	COG2009	succinate dehydrogenase
A2I73_RS08765	COG0322	excinuclease ABC activity
A2I73_RS08770	COG3118	belongs to the thioredoxin family
A2I73_RS08775	COG1193	negative regulation of DNA recombination
A2I73_RS08780	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A2I73_RS08780	COG1796	DNA polymerase
A2I73_RS08790	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
A2I73_RS08795	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A2I73_RS08800	COG0072	phenylalanine-tRNA ligase activity
A2I73_RS08805	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A2I73_RS08810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A2I73_RS08820	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A2I73_RS08830	COG1323	Belongs to the UPF0348 family
A2I73_RS08835	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A2I73_RS08840	COG0742	ribosomal rna small subunit methyltransferase
A2I73_RS08850	COG4471	UPF0298 protein
A2I73_RS08855	COG0584	glycerophosphoryl diester phosphodiesterase
A2I73_RS08860	COG3679	Belongs to the UPF0342 family
A2I73_RS08870	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A2I73_RS08885	COG1612	heme a metabolic process
A2I73_RS08895	COG0772	Belongs to the SEDS family
A2I73_RS08900	COG4838	Belongs to the UPF0358 family
A2I73_RS08905	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A2I73_RS08910	COG4896	Protein conserved in bacteria
A2I73_RS08915	COG1217	gtp-binding protein TYPA
A2I73_RS08925	COG0483	inositol monophosphate 1-phosphatase activity
A2I73_RS08930	COG4493	Belongs to the UPF0637 family
A2I73_RS08940	COG1914	H( )-stimulated, divalent metal cation uptake system
A2I73_RS08955	COG1177	transmembrane transport
A2I73_RS08960	COG1176	ABC-type spermidine putrescine transport system, permease component I
A2I73_RS08965	COG3842	ATPase activity
A2I73_RS08975	COG4476	Belongs to the UPF0223 family
A2I73_RS09005	COG0242	peptide deformylase activity
A2I73_RS09015	COG5503	Protein of unknown function (DUF1447)
A2I73_RS09020	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A2I73_RS09025	COG0569	domain protein
A2I73_RS09030	COG1294	oxidase, subunit
A2I73_RS09035	COG1271	oxidase subunit
A2I73_RS09045	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A2I73_RS09050	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A2I73_RS09060	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A2I73_RS09080	COG4172	Belongs to the ABC transporter superfamily
A2I73_RS09090	COG0151	Belongs to the GarS family
A2I73_RS09095	COG0138	bifunctional purine biosynthesis protein purh
A2I73_RS09105	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A2I73_RS09115	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A2I73_RS09120	COG0047	phosphoribosylformylglycinamidine synthase activity
A2I73_RS09125	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A2I73_RS09130	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A2I73_RS09135	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A2I73_RS09140	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A2I73_RS09145	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A2I73_RS09150	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A2I73_RS09150	COG1017	nitric oxide dioxygenase activity
A2I73_RS09160	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A2I73_RS09165	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A2I73_RS09170	COG1845	cytochrome c oxidase, subunit III
A2I73_RS09175	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A2I73_RS09190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A2I73_RS09195	COG1316	TRANSCRIPTIONal
A2I73_RS09220	COG3594	Acyltransferase
A2I73_RS09225	COG0436	Aminotransferase
A2I73_RS09230	COG1846	Transcriptional regulator
A2I73_RS09235	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A2I73_RS09240	COG2267	carboxylic ester hydrolase activity
A2I73_RS09245	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A2I73_RS09250	COG1169	isochorismate synthase
A2I73_RS09255	COG1575	Belongs to the MenA family. Type 1 subfamily
A2I73_RS09265	COG2314	TM2 domain
A2I73_RS09285	COG4903	ComK protein
A2I73_RS09300	COG4873	Protein conserved in bacteria
A2I73_RS09310	COG0737	Belongs to the 5'-nucleotidase family
A2I73_RS09315	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A2I73_RS09320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A2I73_RS09325	COG0861	Integral membrane protein TerC family
A2I73_RS09330	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A2I73_RS09340	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A2I73_RS09345	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A2I73_RS09350	COG2814	Major facilitator Superfamily
A2I73_RS09355	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A2I73_RS09360	COG2382	esterase
A2I73_RS09370	COG0628	permease
A2I73_RS09380	COG0475	glutathione-regulated potassium exporter activity
A2I73_RS09380	COG0569	domain protein
A2I73_RS09385	COG2239	Acts as a magnesium transporter
A2I73_RS09390	COG0564	pseudouridine synthase activity
A2I73_RS09395	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A2I73_RS09400	COG2357	RelA SpoT domain protein
A2I73_RS09415	COG2346	COG2346, Truncated hemoglobins
A2I73_RS09420	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A2I73_RS09425	COG1164	Oligoendopeptidase f
A2I73_RS09435	COG4862	establishment of competence for transformation
A2I73_RS09440	COG1393	Belongs to the ArsC family
A2I73_RS09445	COG0180	Tryptophanyl-tRNA synthetase
A2I73_RS09450	COG4166	transmembrane transport
A2I73_RS09455	COG4608	Belongs to the ABC transporter superfamily
A2I73_RS09460	COG0444	Belongs to the ABC transporter superfamily
A2I73_RS09465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A2I73_RS09470	COG0601	transmembrane transport
A2I73_RS09490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A2I73_RS09500	COG0542	response to heat
A2I73_RS09515	COG0561	phosphatase activity
A2I73_RS09520	COG0446	pyridine nucleotide-disulphide oxidoreductase
A2I73_RS09530	COG0179	Fumarylacetoacetate (FAA) hydrolase
A2I73_RS09535	COG2311	Membrane
A2I73_RS09540	COG1074	ATP-dependent DNA helicase activity
A2I73_RS09545	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A2I73_RS09560	COG0398	Pfam SNARE associated Golgi protein
A2I73_RS09565	COG0166	Belongs to the GPI family
A2I73_RS09570	COG0137	argininosuccinate synthase activity
A2I73_RS09575	COG0165	Argininosuccinate lyase
A2I73_RS09580	COG0584	glycerophosphoryl diester phosphodiesterase
A2I73_RS09590	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A2I73_RS09595	COG1902	pentaerythritol trinitrate reductase activity
A2I73_RS09600	COG1098	S1 RNA binding domain
A2I73_RS09605	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A2I73_RS09615	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A2I73_RS09615	COG2111	Na H antiporter
A2I73_RS09620	COG2111	Na H antiporter
A2I73_RS09625	COG1006	Multisubunit Na H antiporter MnhC subunit
A2I73_RS09630	COG0651	ATP synthesis coupled electron transport
A2I73_RS09635	COG1863	multisubunit Na H antiporter MnhE subunit
A2I73_RS09640	COG2212	antiporter activity
A2I73_RS09645	COG1320	monovalent cation:proton antiporter activity
A2I73_RS09660	COG2050	protein possibly involved in aromatic compounds catabolism
A2I73_RS09665	COG2056	Na+-H+ antiporter family
A2I73_RS09670	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A2I73_RS09675	COG1252	NADH dehydrogenase
A2I73_RS09680	COG0316	Belongs to the HesB IscA family
A2I73_RS09685	COG4844	belongs to the
A2I73_RS09690	COG1252	NADH dehydrogenase
A2I73_RS09695	COG4837	Protein of unknown function (DUF1462)
A2I73_RS09700	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A2I73_RS09705	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A2I73_RS09710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A2I73_RS09715	COG1696	Membrane protein involved in D-alanine export
A2I73_RS09720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A2I73_RS09730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A2I73_RS09735	COG0647	UMP catabolic process
A2I73_RS09740	COG2445	Protein of unknown function DUF86
A2I73_RS09750	COG4470	Protein conserved in bacteria
A2I73_RS09755	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A2I73_RS09760	COG0737	Belongs to the 5'-nucleotidase family
A2I73_RS09765	COG0730	response to heat
A2I73_RS09770	COG1801	Protein of unknown function DUF72
A2I73_RS09775	COG2070	2-Nitropropane dioxygenase
A2I73_RS09780	COG1253	flavin adenine dinucleotide binding
A2I73_RS09790	COG0454	-acetyltransferase
A2I73_RS09795	COG3223	Belongs to the PsiE family
A2I73_RS09800	COG0719	Fe-S assembly protein
A2I73_RS09805	COG0822	iron-sulfur transferase activity
A2I73_RS09810	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A2I73_RS09815	COG0719	Fe-S assembly protein
A2I73_RS09820	COG0396	ATPase activity
A2I73_RS09830	COG1253	flavin adenine dinucleotide binding
A2I73_RS09840	COG1464	Belongs to the NlpA lipoprotein family
A2I73_RS09845	COG2011	ABC-type metal ion transport system permease component
A2I73_RS09850	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A2I73_RS09855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A2I73_RS09860	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A2I73_RS09865	COG0509	glycine decarboxylation via glycine cleavage system
A2I73_RS09870	COG1393	Belongs to the ArsC family
A2I73_RS09875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A2I73_RS09880	COG0778	Nitroreductase
A2I73_RS09885	COG0710	3-dehydroquinate dehydratase activity
A2I73_RS09890	COG1764	response to oxidative stress
A2I73_RS09905	COG2851	Citrate transporter
A2I73_RS09920	COG2314	TM2 domain
A2I73_RS09960	COG2153	protein acetylation
A2I73_RS09965	COG0346	lactoylglutathione lyase activity
A2I73_RS09980	COG1073	alpha beta
A2I73_RS10010	COG0640	Transcriptional regulator
A2I73_RS10030	COG0346	lactoylglutathione lyase activity
A2I73_RS10075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A2I73_RS10085	COG1937	Protein conserved in bacteria
A2I73_RS10090	COG0730	response to heat
A2I73_RS10095	COG2910	NAD(P)H-binding
A2I73_RS10105	COG1959	2 iron, 2 sulfur cluster binding
A2I73_RS10195	COG1388	LysM domain
A2I73_RS10215	COG0346	lactoylglutathione lyase activity
A2I73_RS10235	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A2I73_RS10240	COG0557	exoribonuclease II activity
A2I73_RS10245	COG1647	Serine aminopeptidase, S33
A2I73_RS10250	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A2I73_RS10260	COG0148	phosphopyruvate hydratase activity
A2I73_RS10265	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A2I73_RS10270	COG0149	triose-phosphate isomerase activity
A2I73_RS10275	COG0126	phosphoglycerate kinase activity
A2I73_RS10300	COG1090	epimerase
A2I73_RS10310	COG0740	serine-type endopeptidase activity
A2I73_RS10320	COG1481	regulation of sporulation
A2I73_RS10325	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A2I73_RS10330	COG1660	Displays ATPase and GTPase activities
A2I73_RS10335	COG0492	ferredoxin-NADP+ reductase activity
A2I73_RS10345	COG0110	maltose O-acetyltransferase activity
A2I73_RS10350	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A2I73_RS10355	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A2I73_RS10365	COG0556	nucleotide-excision repair
A2I73_RS10380	COG3942	CHAP domain
A2I73_RS10380	COG1388	LysM domain
A2I73_RS10385	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A2I73_RS10390	COG0653	protein targeting
A2I73_RS10395	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A2I73_RS10400	COG1040	competence protein
A2I73_RS10405	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A2I73_RS10415	COG1739	Uncharacterized protein family UPF0029
A2I73_RS10420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A2I73_RS10425	COG2199	diguanylate cyclase activity
A2I73_RS10440	COG2195	Cleaves the N-terminal amino acid of tripeptides
A2I73_RS10445	COG1929	Belongs to the glycerate kinase type-1 family
A2I73_RS10465	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A2I73_RS10480	COG4607	ABC-type enterochelin transport system periplasmic component
A2I73_RS10485	COG4604	ABC transporter, ATP-binding protein
A2I73_RS10490	COG4605	iron ion homeostasis
A2I73_RS10495	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A2I73_RS10500	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A2I73_RS10505	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A2I73_RS10510	COG1780	Probably involved in ribonucleotide reductase function
A2I73_RS10520	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A2I73_RS10525	COG3104	oligopeptide transport
A2I73_RS10530	COG3104	oligopeptide transport
A2I73_RS10535	COG1597	lipid kinase activity
A2I73_RS10545	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A2I73_RS10550	COG1174	glycine betaine transport
A2I73_RS10560	COG0514	ATP-dependent DNA helicase (RecQ)
A2I73_RS10565	COG0488	(ABC) transporter
A2I73_RS10575	COG1368	sulfuric ester hydrolase activity
A2I73_RS10585	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A2I73_RS10600	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A2I73_RS10605	COG0512	Glutamine amidotransferase of anthranilate synthase
A2I73_RS10605	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A2I73_RS10610	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A2I73_RS10615	COG0720	synthase
A2I73_RS10620	COG0602	queuosine metabolic process
A2I73_RS10635	COG0463	Glycosyl transferase, family 2
A2I73_RS10640	COG0656	L-ascorbic acid biosynthetic process
A2I73_RS10645	COG1253	flavin adenine dinucleotide binding
A2I73_RS10650	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A2I73_RS10655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A2I73_RS10655	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A2I73_RS10655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A2I73_RS10660	COG1105	Belongs to the carbohydrate kinase PfkB family
A2I73_RS10665	COG1349	DNA-binding transcription factor activity
A2I73_RS10670	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A2I73_RS10675	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A2I73_RS10705	COG0039	L-malate dehydrogenase activity
A2I73_RS10710	COG0586	Pfam SNARE associated Golgi protein
A2I73_RS10720	COG4989	oxidoreductase activity
A2I73_RS10735	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A2I73_RS10740	COG4988	ABC transporter
A2I73_RS10745	COG1968	undecaprenyl-diphosphatase activity
A2I73_RS10755	COG1671	Belongs to the UPF0178 family
A2I73_RS10760	COG1611	Belongs to the LOG family
A2I73_RS10765	COG1279	arginine transmembrane transporter activity
A2I73_RS10770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A2I73_RS10800	COG2814	Major facilitator Superfamily
A2I73_RS10805	COG2839	Protein conserved in bacteria
A2I73_RS10810	COG2814	Major facilitator Superfamily
A2I73_RS10815	COG0583	DNA-binding transcription factor activity
A2I73_RS10825	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A2I73_RS10835	COG0217	transcriptional regulatory protein
A2I73_RS10855	COG1388	LysM domain
A2I73_RS10855	COG3942	CHAP domain
A2I73_RS10860	COG0306	phosphate transporter
A2I73_RS10865	COG1392	Phosphate transport regulator
A2I73_RS10870	COG2205	protein histidine kinase activity
A2I73_RS10875	COG0745	RESPONSE REGULATOR receiver
A2I73_RS10880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A2I73_RS10890	COG0657	acetylesterase activity
A2I73_RS10895	COG3949	Membrane
A2I73_RS10905	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
A2I73_RS10910	COG1461	Dihydroxyacetone kinase
A2I73_RS10915	COG2376	Dihydroxyacetone kinase
A2I73_RS10920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A2I73_RS10925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A2I73_RS10930	COG1120	ATPase activity
A2I73_RS10935	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A2I73_RS10940	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A2I73_RS10945	COG1132	(ABC) transporter
A2I73_RS10955	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A2I73_RS10965	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A2I73_RS10970	COG1682	transport, permease protein
A2I73_RS10975	COG1134	teichoic acid transport
A2I73_RS10980	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A2I73_RS11000	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A2I73_RS11005	COG0803	Belongs to the bacterial solute-binding protein 9 family
A2I73_RS11015	COG1320	monovalent cation:proton antiporter activity
A2I73_RS11020	COG2212	antiporter activity
A2I73_RS11025	COG1863	multisubunit Na H antiporter MnhE subunit
A2I73_RS11030	COG0651	ATP synthesis coupled electron transport
A2I73_RS11035	COG1006	Multisubunit Na H antiporter MnhC subunit
A2I73_RS11040	COG2111	Na H antiporter
A2I73_RS11045	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A2I73_RS11045	COG2111	Na H antiporter
A2I73_RS11085	COG0596	Alpha beta hydrolase
A2I73_RS11110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A2I73_RS11115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A2I73_RS11125	COG0018	arginyl-trna synthetase
A2I73_RS11140	COG1078	dGTPase activity
A2I73_RS11145	COG0456	acetyltransferase
A2I73_RS11150	COG0655	NAD(P)H dehydrogenase (quinone) activity
A2I73_RS11155	COG0667	Aldo Keto reductase
A2I73_RS11160	COG4844	belongs to the
A2I73_RS11180	COG0095	Lipoate-protein ligase
A2I73_RS11185	COG0280	phosphate acetyltransferase
A2I73_RS11190	COG3253	May function as heme-dependent peroxidase
A2I73_RS11210	COG2363	Small membrane protein
A2I73_RS11220	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A2I73_RS11225	COG0351	phosphomethylpyrimidine kinase
A2I73_RS11255	COG0183	Belongs to the thiolase family
A2I73_RS11260	COG0318	PFAM AMP-dependent synthetase and ligase
A2I73_RS11270	COG3493	citrate carrier protein
A2I73_RS11275	COG0384	phenazine biosynthesis protein PhzF
A2I73_RS11285	COG2329	Antibiotic biosynthesis monooxygenase
A2I73_RS11305	COG2832	Protein of unknown function (DUF454)
A2I73_RS11310	COG4565	transcriptional regulatory protein
A2I73_RS11315	COG3290	protein histidine kinase activity
A2I73_RS11320	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A2I73_RS11325	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A2I73_RS11330	COG0363	glucosamine-6-phosphate deaminase activity
A2I73_RS11340	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A2I73_RS11345	COG1469	GTP cyclohydrolase I activity
A2I73_RS11360	COG0431	NADPH-dependent FMN reductase
A2I73_RS11365	COG0561	phosphatase activity
A2I73_RS11375	COG1428	Deoxynucleoside kinase
A2I73_RS11380	COG1428	Deoxynucleoside kinase
A2I73_RS11390	COG0546	phosphoglycolate phosphatase activity
A2I73_RS11410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A2I73_RS11425	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A2I73_RS11430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A2I73_RS11450	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A2I73_RS11460	COG2824	Alkylphosphonate utilization operon protein PhnA
A2I73_RS11470	COG1113	amino acid transport
A2I73_RS11475	COG3239	Fatty acid desaturase
A2I73_RS11485	COG2040	homocysteine
A2I73_RS11490	COG0833	amino acid
A2I73_RS11500	COG0010	Belongs to the arginase family
A2I73_RS11505	COG1914	H( )-stimulated, divalent metal cation uptake system
A2I73_RS11520	COG1069	ribulokinase activity
A2I73_RS11525	COG1063	alcohol dehydrogenase
A2I73_RS11530	COG2814	Major facilitator Superfamily
A2I73_RS11535	COG1349	DNA-binding transcription factor activity
A2I73_RS11545	COG1028	Short-chain dehydrogenase reductase Sdr
A2I73_RS11550	COG1312	Catalyzes the dehydration of D-mannonate
A2I73_RS11555	COG1904	glucuronate isomerase
A2I73_RS11575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A2I73_RS11590	COG0583	DNA-binding transcription factor activity
A2I73_RS11610	COG0667	Aldo Keto reductase
A2I73_RS11625	COG1686	Belongs to the peptidase S11 family
A2I73_RS11640	COG1028	Short-chain dehydrogenase reductase Sdr
A2I73_RS11645	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A2I73_RS11650	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A2I73_RS11690	COG1473	amidohydrolase
A2I73_RS11695	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A2I73_RS11700	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A2I73_RS11705	COG0049	tRNA binding
A2I73_RS11710	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A2I73_RS11720	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A2I73_RS11725	COG0085	RNA polymerase activity
A2I73_RS11730	COG2813	Specifically methylates the guanine in position
A2I73_RS11735	COG0222	ribosome binding
A2I73_RS11740	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A2I73_RS11745	COG0081	regulation of translation
A2I73_RS11750	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A2I73_RS11755	COG0250	Participates in transcription elongation, termination and antitermination
A2I73_RS11780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A2I73_RS11785	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
A2I73_RS11790	COG0215	cysteine-tRNA ligase activity
A2I73_RS11795	COG1045	serine acetyltransferase
A2I73_RS11800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A2I73_RS11805	COG4956	integral membrane protein (PIN domain superfamily)
A2I73_RS11810	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A2I73_RS11815	COG0542	response to heat
A2I73_RS11820	COG3869	Catalyzes the specific phosphorylation of arginine residues in
A2I73_RS11825	COG3880	PFAM UvrB UvrC protein
A2I73_RS11830	COG4463	regulation of RNA biosynthetic process
A2I73_RS11835	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A2I73_RS11840	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
A2I73_RS11845	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
A2I73_RS11850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A2I73_RS11935	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A2I73_RS11940	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A2I73_RS11960	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A2I73_RS11965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A2I73_RS11980	COG1098	S1 RNA binding domain
A2I73_RS11990	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A2I73_RS11995	COG3956	TIGRFAM MazG family protein
A2I73_RS12000	COG2244	polysaccharide biosynthetic process
A2I73_RS12005	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A2I73_RS12010	COG0193	aminoacyl-tRNA hydrolase activity
A2I73_RS12015	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A2I73_RS12020	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A2I73_RS12025	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A2I73_RS12030	COG2088	sporulation resulting in formation of a cellular spore
A2I73_RS12035	COG0251	oxidation-reduction process
A2I73_RS12040	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A2I73_RS12045	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A2I73_RS12050	COG4466	Protein conserved in bacteria
A2I73_RS12055	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A2I73_RS12060	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A2I73_RS12065	COG0084	hydrolase, TatD family'
A2I73_RS12070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A2I73_RS12070	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A2I73_RS12075	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A2I73_RS12080	COG2827	Endonuclease containing a URI domain
A2I73_RS12085	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A2I73_RS12090	COG4467	Involved in initiation control of chromosome replication
A2I73_RS12095	COG1774	PSP1 C-terminal conserved region
A2I73_RS12100	COG0470	DNA polymerase III
A2I73_RS12105	COG3870	Protein conserved in bacteria
A2I73_RS12110	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A2I73_RS12115	COG1982	Orn Lys Arg decarboxylase major
A2I73_RS12150	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A2I73_RS12155	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A2I73_RS12160	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A2I73_RS12165	COG3153	acetyltransferase
A2I73_RS12175	COG2188	Transcriptional regulator
A2I73_RS12180	COG0366	Alpha amylase catalytic
A2I73_RS12185	COG1263	PTS System
A2I73_RS12185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A2I73_RS12195	COG0493	'glutamate synthase
A2I73_RS12200	COG0069	glutamate synthase activity
A2I73_RS12200	COG0070	glutamate synthase
A2I73_RS12200	COG0067	glutamate synthase
A2I73_RS12220	COG0004	ammonium transporteR
A2I73_RS12225	COG0494	nUDIX hydrolase
A2I73_RS12235	COG3942	CHAP domain
A2I73_RS12235	COG1388	LysM domain
A2I73_RS12245	COG0129	dihydroxy-acid dehydratase activity
A2I73_RS12260	COG0733	neurotransmitter:sodium symporter activity
A2I73_RS12265	COG1114	Component of the transport system for branched-chain amino acids
A2I73_RS12270	COG5646	InterPro IPR014922
A2I73_RS12275	COG2268	Band 7 protein
A2I73_RS12300	COG0789	Transcriptional regulator
A2I73_RS12315	COG4195	phage-related replication protein
A2I73_RS12320	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A2I73_RS12325	COG2807	transmembrane transport
A2I73_RS12340	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A2I73_RS12345	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A2I73_RS12350	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A2I73_RS12355	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A2I73_RS12360	COG3257	ureidoglycine aminohydrolase activity
A2I73_RS12365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A2I73_RS12375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A2I73_RS12380	COG0406	alpha-ribazole phosphatase activity
A2I73_RS12390	COG1595	DNA-templated transcription, initiation
A2I73_RS12400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A2I73_RS12415	COG1876	peptidase activity
A2I73_RS12420	COG0753	catalase activity
A2I73_RS12430	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A2I73_RS12435	COG1953	Uracil, thiamine, allantoin
A2I73_RS12440	COG2508	Transcriptional regulator
A2I73_RS12445	COG0456	acetyltransferase
A2I73_RS12445	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A2I73_RS12450	COG2814	Major facilitator Superfamily
A2I73_RS12470	COG1301	dicarboxylic acid transport
A2I73_RS12480	COG0519	Catalyzes the synthesis of GMP from XMP
A2I73_RS12480	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A2I73_RS12485	COG0516	GMP reductase activity
A2I73_RS12485	COG0517	IMP dehydrogenase activity
A2I73_RS12490	COG2233	PERMEase
A2I73_RS12495	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A2I73_RS12510	COG5183	chlorophyll binding
A2I73_RS12515	COG1823	symporter activity
A2I73_RS12525	COG1760	l-serine dehydratase
A2I73_RS12530	COG1760	l-serine dehydratase
A2I73_RS12545	COG0778	Nitroreductase
A2I73_RS12550	COG0753	catalase activity
A2I73_RS12555	COG0450	alkyl hydroperoxide reductase
A2I73_RS12560	COG3634	alkyl hydroperoxide reductase activity
A2I73_RS12595	COG1280	lysine exporter protein (LysE YggA)
A2I73_RS12600	COG2076	Multidrug Resistance protein
A2I73_RS12605	COG2076	Multidrug Resistance protein
A2I73_RS12640	COG4195	phage-related replication protein
A2I73_RS12645	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A2I73_RS12670	COG0583	DNA-binding transcription factor activity
A2I73_RS12680	COG3266	domain, Protein
A2I73_RS12680	COG4193	domain, Protein
A2I73_RS12680	COG5632	N-Acetylmuramoyl-L-alanine amidase
A2I73_RS12700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A2I73_RS12705	COG2210	Belongs to the sulfur carrier protein TusA family
A2I73_RS12710	COG1937	Protein conserved in bacteria
A2I73_RS12715	COG0730	response to heat
A2I73_RS12725	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A2I73_RS12765	COG0360	Binds together with S18 to 16S ribosomal RNA
A2I73_RS12775	COG0012	GTP binding
A2I73_RS12780	COG4481	Protein conserved in bacteria
A2I73_RS12785	COG0668	transmembrane transport
A2I73_RS12790	COG5609	conserved protein (DUF2294)
A2I73_RS12795	COG3002	Belongs to the UPF0753 family
A2I73_RS12800	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A2I73_RS12805	COG1917	Cupin 2, conserved barrel domain protein
A2I73_RS12805	COG2207	Transcriptional regulator
A2I73_RS12810	COG1486	melibiose metabolic process
A2I73_RS12815	COG2211	Major facilitator Superfamily
A2I73_RS12820	COG2084	Dehydrogenase
A2I73_RS12825	COG1064	alcohol dehydrogenase
A2I73_RS12830	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A2I73_RS12855	COG0577	efflux transmembrane transporter activity
A2I73_RS12860	COG1136	(ABC) transporter
A2I73_RS12865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A2I73_RS12870	COG1288	antiporter activity
A2I73_RS12880	COG4978	Transcriptional regulator
A2I73_RS12880	COG0789	Transcriptional regulator
A2I73_RS12900	COG1012	belongs to the aldehyde dehydrogenase family
A2I73_RS12910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A2I73_RS12915	COG2814	Major facilitator Superfamily
A2I73_RS12920	COG1473	amidohydrolase
A2I73_RS12925	COG2814	Major facilitator Superfamily
A2I73_RS12930	COG1733	regulation of RNA biosynthetic process
A2I73_RS12935	COG2030	dehydratase
A2I73_RS12940	COG3759	membrane
A2I73_RS12945	COG2814	Major facilitator Superfamily
A2I73_RS12960	COG0772	Belongs to the SEDS family
A2I73_RS12965	COG2226	methyltransferase
A2I73_RS12970	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A2I73_RS12980	COG0529	Catalyzes the synthesis of activated sulfate
A2I73_RS12985	COG2046	Belongs to the sulfate adenylyltransferase family
A2I73_RS12990	COG0730	response to heat
A2I73_RS13010	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A2I73_RS13015	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A2I73_RS13020	COG0175	sulfate reduction
A2I73_RS13025	COG1475	DNA binding
A2I73_RS13030	COG0626	cystathionine gamma-synthase activity
A2I73_RS13035	COG0626	cystathionine gamma-synthase activity
A2I73_RS13040	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A2I73_RS13040	COG0646	methionine synthase
A2I73_RS13045	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A2I73_RS13055	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A2I73_RS13080	COG0183	Belongs to the thiolase family
A2I73_RS13090	COG1960	acyl-CoA dehydrogenase activity
A2I73_RS13095	COG0318	PFAM AMP-dependent synthetase and ligase
A2I73_RS13105	COG2239	Acts as a magnesium transporter
A2I73_RS13110	COG0803	Belongs to the bacterial solute-binding protein 9 family
A2I73_RS13115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A2I73_RS13135	COG0561	phosphatase activity
A2I73_RS13140	COG0583	DNA-binding transcription factor activity
A2I73_RS13145	COG1607	acyl-coa hydrolase
A2I73_RS13155	COG2755	lipolytic protein G-D-S-L family
A2I73_RS13155	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A2I73_RS13160	COG1442	glycosyl transferase family 8
A2I73_RS13160	COG1216	Glycosyl transferase, family 2
A2I73_RS13165	COG0463	Glycosyl transferase, family 2
A2I73_RS13165	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A2I73_RS13170	COG0463	Glycosyl transferase, family 2
A2I73_RS13170	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A2I73_RS13195	COG1028	Short-chain dehydrogenase reductase Sdr
A2I73_RS13200	COG0531	amino acid
A2I73_RS13205	COG0656	L-ascorbic acid biosynthetic process
A2I73_RS13210	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A2I73_RS13235	COG0789	Transcriptional regulator
A2I73_RS13245	COG0450	alkyl hydroperoxide reductase
A2I73_RS13250	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A2I73_RS13260	COG2271	Major facilitator Superfamily
A2I73_RS13265	COG1966	Carbon starvation protein
A2I73_RS13275	COG0357	Ribosomal RNA small subunit methyltransferase G
A2I73_RS13280	COG0445	tRNA wobble uridine modification
A2I73_RS13285	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A2I73_RS13290	COG0594	ribonuclease P activity
A2I73_RS13340	COG1063	alcohol dehydrogenase
A2I73_RS13355	COG0583	DNA-binding transcription factor activity
A2I73_RS13380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A2I73_RS13385	COG2210	Belongs to the sulfur carrier protein TusA family
A2I73_RS13390	COG1937	Protein conserved in bacteria
A2I73_RS13395	COG0730	response to heat
A2I73_RS13400	COG2910	NAD(P)H-binding
A2I73_RS13410	COG1959	2 iron, 2 sulfur cluster binding
A2I73_RS13495	COG1388	LysM domain