locus-tag	class	description
SHELL_RS00030	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SHELL_RS00040	COG0175	sulfate reduction
SHELL_RS00055	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SHELL_RS00060	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SHELL_RS00075	COG0668	transmembrane transport
SHELL_RS00085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SHELL_RS00090	COG0528	UMP kinase activity
SHELL_RS00135	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SHELL_RS00160	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
SHELL_RS00175	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SHELL_RS00180	COG0519	Catalyzes the synthesis of GMP from XMP
SHELL_RS00180	COG0518	GMP synthase (glutamine-hydrolyzing) activity
SHELL_RS00200	COG0393	Putative heavy-metal-binding
SHELL_RS00220	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SHELL_RS00235	COG0189	ligase activity
SHELL_RS00265	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SHELL_RS00265	COG1796	DNA polymerase
SHELL_RS00270	COG0525	valine-tRNA ligase activity
SHELL_RS00295	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
SHELL_RS00335	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SHELL_RS00335	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SHELL_RS00345	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SHELL_RS00360	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SHELL_RS00375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SHELL_RS00390	COG0585	pseudouridine synthase activity
SHELL_RS00415	COG1131	(ABC) transporter
SHELL_RS00425	COG2211	Major facilitator Superfamily
SHELL_RS00445	COG1486	melibiose metabolic process
SHELL_RS00455	COG2894	cell division
SHELL_RS00460	COG0489	protein tyrosine kinase activity
SHELL_RS00495	COG0813	purine-nucleoside phosphorylase activity
SHELL_RS00500	COG1063	alcohol dehydrogenase
SHELL_RS00620	COG0306	phosphate transporter
SHELL_RS00630	COG2414	aldehyde ferredoxin oxidoreductase
SHELL_RS00645	COG1032	radical SAM domain protein
SHELL_RS00650	COG0535	radical SAM domain protein
SHELL_RS00670	COG0475	glutathione-regulated potassium exporter activity
SHELL_RS00680	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SHELL_RS00690	COG1863	multisubunit Na H antiporter MnhE subunit
SHELL_RS00715	COG2212	antiporter activity
SHELL_RS00725	COG0649	NAD binding
SHELL_RS00730	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SHELL_RS00735	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SHELL_RS00740	COG0651	ATP synthesis coupled electron transport
SHELL_RS00750	COG1185	polyribonucleotide nucleotidyltransferase activity
SHELL_RS00795	COG1185	polyribonucleotide nucleotidyltransferase activity
SHELL_RS00800	COG2264	protein methyltransferase activity
SHELL_RS00815	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SHELL_RS00820	COG0116	Belongs to the methyltransferase superfamily
SHELL_RS00820	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SHELL_RS00860	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SHELL_RS00880	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SHELL_RS00985	COG4637	Psort location Cytoplasmic, score
SHELL_RS01000	COG1401	restriction endodeoxyribonuclease activity
SHELL_RS01085	COG0167	dihydroorotate dehydrogenase activity
SHELL_RS01090	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
SHELL_RS01100	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
SHELL_RS01105	COG0540	Belongs to the ATCase OTCase family
SHELL_RS01110	COG0284	orotidine-5'-phosphate decarboxylase activity
SHELL_RS01110	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SHELL_RS01120	COG0504	CTP synthase activity
SHELL_RS01125	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SHELL_RS01155	COG2239	Acts as a magnesium transporter
SHELL_RS01235	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SHELL_RS01240	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SHELL_RS01265	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
SHELL_RS01280	COG1716	ATPase activity
SHELL_RS01310	COG0009	L-threonylcarbamoyladenylate synthase
SHELL_RS01335	COG2342	PFAM TM1410 hypothetical-related protein
SHELL_RS01375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SHELL_RS01380	COG1872	DUF167
SHELL_RS01390	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SHELL_RS01425	COG0813	purine-nucleoside phosphorylase activity
SHELL_RS01495	COG1535	isochorismatase
SHELL_RS01495	COG3433	isochorismatase activity
SHELL_RS01500	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SHELL_RS01500	COG0731	radical SAM domain protein
SHELL_RS01530	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SHELL_RS01540	COG1342	Belongs to the UPF0251 family
SHELL_RS01545	COG0142	geranyltranstransferase activity
SHELL_RS01555	COG0284	orotidine-5'-phosphate decarboxylase activity
SHELL_RS01560	COG0180	Tryptophanyl-tRNA synthetase
SHELL_RS01565	COG0402	S-adenosylhomocysteine deaminase activity
SHELL_RS01570	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SHELL_RS01580	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SHELL_RS01645	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SHELL_RS01645	COG1793	dna ligase
SHELL_RS01655	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SHELL_RS01665	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SHELL_RS01670	COG0045	succinate-CoA ligase (ADP-forming) activity
SHELL_RS01690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SHELL_RS01695	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
SHELL_RS01705	COG0622	Phosphoesterase
SHELL_RS01715	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SHELL_RS01715	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SHELL_RS01730	COG0546	phosphoglycolate phosphatase activity
SHELL_RS01740	COG0314	molybdopterin synthase activity
SHELL_RS01775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SHELL_RS01775	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SHELL_RS01815	COG0714	Associated with various cellular activities
SHELL_RS01850	COG1404	Belongs to the peptidase S8 family
SHELL_RS01855	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SHELL_RS01855	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SHELL_RS01900	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SHELL_RS01900	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SHELL_RS01910	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SHELL_RS01930	COG5012	cobalamin binding
SHELL_RS01940	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
SHELL_RS01950	COG4946	Tricorn protease homolog
SHELL_RS01950	COG1506	peptidase
SHELL_RS01950	COG0823	Involved in the tonB-independent uptake of proteins
SHELL_RS01970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
SHELL_RS01970	COG0730	response to heat
SHELL_RS01995	COG1131	(ABC) transporter
SHELL_RS02010	COG1522	sequence-specific DNA binding
SHELL_RS02020	COG0563	adenylate kinase activity
SHELL_RS02030	COG0037	tRNA processing
SHELL_RS02055	COG1122	ATPase activity
SHELL_RS02080	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SHELL_RS02100	COG0402	S-adenosylhomocysteine deaminase activity
SHELL_RS02110	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SHELL_RS02125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SHELL_RS02125	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SHELL_RS02175	COG2264	protein methyltransferase activity
SHELL_RS02195	COG1120	ATPase activity
SHELL_RS02235	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SHELL_RS02250	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SHELL_RS02260	COG4555	ABC transporter
SHELL_RS02270	COG1141	Ferredoxin
SHELL_RS02295	COG0747	negative chemotaxis
SHELL_RS02300	COG0601	transmembrane transport
SHELL_RS02305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SHELL_RS02310	COG0444	Belongs to the ABC transporter superfamily
SHELL_RS02315	COG4608	Belongs to the ABC transporter superfamily
SHELL_RS02320	COG5016	pyruvate
SHELL_RS02320	COG0511	ligase activity, forming carbon-carbon bonds
SHELL_RS02330	COG0529	Catalyzes the synthesis of activated sulfate
SHELL_RS02340	COG2046	Belongs to the sulfate adenylyltransferase family
SHELL_RS02350	COG0471	metal ion transport
SHELL_RS02360	COG0017	Asparaginyl-tRNA synthetase
SHELL_RS02415	COG0515	serine threonine protein kinase
SHELL_RS02415	COG2815	serine threonine protein kinase
SHELL_RS02455	COG2815	serine threonine protein kinase
SHELL_RS02455	COG0515	serine threonine protein kinase
SHELL_RS02480	COG2815	serine threonine protein kinase
SHELL_RS02480	COG0515	serine threonine protein kinase
SHELL_RS02535	COG1337	RAMP superfamily
SHELL_RS02555	COG0521	Mo-molybdopterin cofactor biosynthetic process
SHELL_RS02560	COG3842	ATPase activity
SHELL_RS02590	COG0017	Asparaginyl-tRNA synthetase
SHELL_RS02620	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SHELL_RS02645	COG2095	MarC family integral membrane protein
SHELL_RS02655	COG3842	ATPase activity
SHELL_RS02660	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
SHELL_RS02665	COG0725	ABC transporter, periplasmic molybdate-binding protein
SHELL_RS02675	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SHELL_RS02685	COG0436	Aminotransferase
SHELL_RS02730	COG3842	ATPase activity
SHELL_RS02735	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SHELL_RS02750	COG0584	glycerophosphoryl diester phosphodiesterase
SHELL_RS02775	COG1458	PINc domain ribonuclease
SHELL_RS02780	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SHELL_RS02780	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SHELL_RS02800	COG0475	glutathione-regulated potassium exporter activity
SHELL_RS02815	COG0719	Fe-S assembly protein
SHELL_RS02830	COG1335	isochorismatase
SHELL_RS02850	COG2084	Dehydrogenase
SHELL_RS02855	COG0589	response to stress
SHELL_RS02860	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
SHELL_RS02865	COG0126	phosphoglycerate kinase activity
SHELL_RS02870	COG0167	dihydroorotate dehydrogenase activity
SHELL_RS02920	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SHELL_RS02935	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SHELL_RS02955	COG0489	protein tyrosine kinase activity
SHELL_RS03010	COG0303	'Molybdopterin
SHELL_RS03015	COG4581	dead DEAH box helicase
SHELL_RS03045	COG1166	arginine decarboxylase activity
SHELL_RS03060	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SHELL_RS03065	COG1881	PFAM PEBP family protein
SHELL_RS03130	COG0095	Lipoate-protein ligase
SHELL_RS03150	COG4133	protoheme IX ABC transporter activity
SHELL_RS03160	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SHELL_RS03165	COG1522	sequence-specific DNA binding
SHELL_RS03170	COG0174	glutamine synthetase
SHELL_RS03180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SHELL_RS03195	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SHELL_RS03210	COG1131	(ABC) transporter
SHELL_RS03225	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SHELL_RS03230	COG1392	Phosphate transport regulator
SHELL_RS03285	COG3842	ATPase activity
SHELL_RS03290	COG4149	molybdate abc transporter
SHELL_RS03335	COG0574	Belongs to the PEP-utilizing enzyme family
SHELL_RS03335	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SHELL_RS03340	COG0439	Biotin carboxylase
SHELL_RS03370	COG1079	Belongs to the binding-protein-dependent transport system permease family
SHELL_RS03375	COG4603	Belongs to the binding-protein-dependent transport system permease family
SHELL_RS03380	COG3845	ABC transporter
SHELL_RS03440	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
SHELL_RS03455	COG0495	leucyl-tRNA aminoacylation
SHELL_RS03465	COG0719	Fe-S assembly protein
SHELL_RS03470	COG0719	Fe-S assembly protein
SHELL_RS03475	COG1131	(ABC) transporter
SHELL_RS03485	COG0463	Glycosyl transferase, family 2
SHELL_RS03490	COG3842	ATPase activity
SHELL_RS03495	COG3833	ABC-type maltose transport systems, permease component
SHELL_RS03525	COG0121	glutamine amidotransferase
SHELL_RS03535	COG0436	Aminotransferase
SHELL_RS03545	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
SHELL_RS03570	COG3383	formate dehydrogenase (NAD+) activity
SHELL_RS03580	COG1012	belongs to the aldehyde dehydrogenase family
SHELL_RS03585	COG0438	transferase activity, transferring glycosyl groups
SHELL_RS03600	COG0395	ABC-type sugar transport system, permease component
SHELL_RS03605	COG1175	transmembrane transport
SHELL_RS03610	COG1653	transport
SHELL_RS03620	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SHELL_RS03630	COG0475	glutathione-regulated potassium exporter activity
SHELL_RS03670	COG0295	cytidine deaminase activity
SHELL_RS03685	COG1131	(ABC) transporter
SHELL_RS03705	COG1078	dGTPase activity
SHELL_RS03710	COG0668	transmembrane transport
SHELL_RS03730	COG0450	alkyl hydroperoxide reductase
SHELL_RS03740	COG0426	domain, Protein
SHELL_RS03750	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SHELL_RS03760	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
SHELL_RS03770	COG1122	ATPase activity
SHELL_RS03775	COG0351	phosphomethylpyrimidine kinase
SHELL_RS03780	COG1522	sequence-specific DNA binding
SHELL_RS03790	COG2033	superoxide reductase activity
SHELL_RS03800	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SHELL_RS03815	COG1121	(ABC) transporter
SHELL_RS03850	COG3608	succinylglutamate desuccinylase aspartoacylase
SHELL_RS03850	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SHELL_RS03880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SHELL_RS03895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
SHELL_RS03900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SHELL_RS03910	COG0037	tRNA processing
SHELL_RS03920	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
SHELL_RS03925	COG4608	Belongs to the ABC transporter superfamily
SHELL_RS03930	COG0444	Belongs to the ABC transporter superfamily
SHELL_RS03940	COG0601	transmembrane transport
SHELL_RS03945	COG0747	negative chemotaxis
SHELL_RS03950	COG2723	6-phospho-beta-galactosidase activity
SHELL_RS03955	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
SHELL_RS03960	COG0598	Magnesium transport protein CorA
SHELL_RS03995	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SHELL_RS04005	COG0018	arginyl-trna synthetase
SHELL_RS04010	COG0315	cyclic pyranopterin monophosphate synthase activity
SHELL_RS04130	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SHELL_RS04135	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
SHELL_RS04135	COG0493	'glutamate synthase
SHELL_RS04140	COG2414	aldehyde ferredoxin oxidoreductase
SHELL_RS04150	COG0747	negative chemotaxis
SHELL_RS04155	COG0601	transmembrane transport
SHELL_RS04160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SHELL_RS04165	COG0444	Belongs to the ABC transporter superfamily
SHELL_RS04170	COG4608	Belongs to the ABC transporter superfamily
SHELL_RS04205	COG1136	(ABC) transporter
SHELL_RS04245	COG0714	Associated with various cellular activities
SHELL_RS04270	COG1215	transferase activity, transferring glycosyl groups
SHELL_RS04290	COG1215	transferase activity, transferring glycosyl groups
SHELL_RS04320	COG0438	transferase activity, transferring glycosyl groups
SHELL_RS04325	COG0275	rRNA processing
SHELL_RS04365	COG0726	polysaccharide deacetylase
SHELL_RS04370	COG0438	transferase activity, transferring glycosyl groups
SHELL_RS04390	COG1091	dTDP-4-dehydrorhamnose reductase activity
SHELL_RS04395	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SHELL_RS04455	COG1234	tRNA 3'-trailer cleavage
SHELL_RS04485	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SHELL_RS04520	COG1940	carbohydrate kinase activity
SHELL_RS04535	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SHELL_RS04570	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SHELL_RS04615	COG1111	helicase
SHELL_RS04615	COG1205	dead DEAH box helicase
SHELL_RS04625	COG0312	modulator of DNA gyrase
SHELL_RS04630	COG0312	modulator of DNA gyrase
SHELL_RS04635	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SHELL_RS04635	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SHELL_RS04645	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SHELL_RS04650	COG1994	Peptidase M50
SHELL_RS04795	COG0445	tRNA wobble uridine modification
SHELL_RS04805	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
SHELL_RS04820	COG1574	metal-dependent hydrolase with the TIM-barrel fold
SHELL_RS04830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SHELL_RS04835	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SHELL_RS04850	COG1013	pyruvate-flavodoxin oxidoreductase activity
SHELL_RS04855	COG0674	pyruvate-flavodoxin oxidoreductase activity
SHELL_RS04865	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SHELL_RS04880	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SHELL_RS04885	COG1013	pyruvate-flavodoxin oxidoreductase activity
SHELL_RS04900	COG0534	Mate efflux family protein
SHELL_RS04905	COG0577	efflux transmembrane transporter activity
SHELL_RS04905	COG1136	(ABC) transporter
SHELL_RS04915	COG1136	(ABC) transporter
SHELL_RS04920	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SHELL_RS04945	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SHELL_RS04945	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SHELL_RS04955	COG0475	glutathione-regulated potassium exporter activity
SHELL_RS04970	COG4770	biotin carboxylase activity
SHELL_RS05015	COG0714	Associated with various cellular activities
SHELL_RS05060	COG0577	efflux transmembrane transporter activity
SHELL_RS05060	COG1136	(ABC) transporter
SHELL_RS05065	COG1136	(ABC) transporter
SHELL_RS05070	COG1136	(ABC) transporter
SHELL_RS05120	COG0297	glycogen (starch) synthase activity
SHELL_RS05125	COG1449	Belongs to the glycosyl hydrolase 57 family
SHELL_RS05130	COG2723	6-phospho-beta-galactosidase activity
SHELL_RS05135	COG2814	Major facilitator Superfamily
SHELL_RS05160	COG1131	(ABC) transporter
SHELL_RS05175	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
SHELL_RS05180	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SHELL_RS05195	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SHELL_RS05205	COG0017	Asparaginyl-tRNA synthetase
SHELL_RS05215	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SHELL_RS05225	COG2264	protein methyltransferase activity
SHELL_RS05230	COG1702	phosphate starvation-inducible protein PhoH
SHELL_RS05275	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SHELL_RS05280	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SHELL_RS05290	COG2151	metal-sulfur cluster biosynthetic enzyme
SHELL_RS05295	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SHELL_RS05320	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SHELL_RS05325	COG0312	modulator of DNA gyrase
SHELL_RS05330	COG0312	modulator of DNA gyrase
SHELL_RS05340	COG1201	RNA secondary structure unwinding
SHELL_RS05375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SHELL_RS05395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SHELL_RS05400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SHELL_RS05405	COG0601	transmembrane transport
SHELL_RS05425	COG4608	Belongs to the ABC transporter superfamily
SHELL_RS05430	COG0444	Belongs to the ABC transporter superfamily
SHELL_RS05440	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SHELL_RS05455	COG0501	Belongs to the peptidase M48B family
SHELL_RS05485	COG1793	dna ligase
SHELL_RS05495	COG1573	uracil-dna glycosylase
SHELL_RS05525	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SHELL_RS05530	COG2078	PFAM AMMECR1 domain protein
SHELL_RS05540	COG2239	Acts as a magnesium transporter
SHELL_RS05550	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SHELL_RS05550	COG0517	IMP dehydrogenase activity
SHELL_RS05550	COG0617	tRNA 3'-terminal CCA addition
SHELL_RS05585	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
SHELL_RS05615	COG0076	glutamate decarboxylase activity
SHELL_RS05620	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SHELL_RS05645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SHELL_RS05665	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SHELL_RS05670	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SHELL_RS05705	COG0148	phosphopyruvate hydratase activity
SHELL_RS05725	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SHELL_RS05740	COG0459	protein refolding
SHELL_RS05790	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SHELL_RS05795	COG0252	asparaginase activity
SHELL_RS05825	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
SHELL_RS05855	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
SHELL_RS05875	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SHELL_RS05905	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SHELL_RS05915	COG1234	tRNA 3'-trailer cleavage
SHELL_RS05930	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SHELL_RS05980	COG2255	four-way junction helicase activity
SHELL_RS06005	COG0569	domain protein
SHELL_RS06010	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SHELL_RS06040	COG1404	Belongs to the peptidase S8 family
SHELL_RS06080	COG0405	Gamma-glutamyltransferase
SHELL_RS06085	COG0730	response to heat
SHELL_RS06090	COG0656	L-ascorbic acid biosynthetic process
SHELL_RS06120	COG0714	Associated with various cellular activities
SHELL_RS06145	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SHELL_RS06155	COG2414	aldehyde ferredoxin oxidoreductase
SHELL_RS06225	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SHELL_RS06260	COG1394	ATPase activity, coupled to movement of substances
SHELL_RS06275	COG1269	ATP hydrolysis coupled proton transport
SHELL_RS06310	COG0235	Class ii aldolase
SHELL_RS06330	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SHELL_RS06345	COG4974	Belongs to the 'phage' integrase family
SHELL_RS06380	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SHELL_RS06385	COG1085	galactose-1-phosphate uridylyltransferase
SHELL_RS06410	COG0561	phosphatase activity
SHELL_RS06470	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SHELL_RS06485	COG0023	Translation Initiation Factor
SHELL_RS06500	COG0423	glycine-tRNA ligase activity
SHELL_RS06515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SHELL_RS06535	COG0163	prenyltransferase activity
SHELL_RS06545	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SHELL_RS06550	COG1444	tRNA N-acetyltransferase activity
SHELL_RS06555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SHELL_RS06560	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SHELL_RS06565	COG1110	DNA topoisomerase II activity
SHELL_RS06580	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SHELL_RS06595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SHELL_RS06600	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
SHELL_RS06600	COG2146	nitrite reductase [NAD(P)H] activity
SHELL_RS06610	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SHELL_RS06615	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SHELL_RS06620	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SHELL_RS06630	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SHELL_RS06635	COG0509	glycine decarboxylation via glycine cleavage system
SHELL_RS06690	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SHELL_RS06705	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SHELL_RS06730	COG1469	GTP cyclohydrolase I activity
SHELL_RS06735	COG0720	synthase
SHELL_RS06770	COG0081	regulation of translation
SHELL_RS06775	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SHELL_RS06790	COG0552	protein localization to endoplasmic reticulum
SHELL_RS06855	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SHELL_RS06860	COG0717	Belongs to the dCTP deaminase family
SHELL_RS06865	COG0477	Major facilitator Superfamily
SHELL_RS06875	COG1489	DNA binding
SHELL_RS06900	COG0437	4 iron, 4 sulfur cluster binding
SHELL_RS06915	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SHELL_RS06940	COG0671	phosphoesterase, PA-phosphatase related
SHELL_RS06950	COG2813	Specifically methylates the guanine in position
SHELL_RS06995	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SHELL_RS07015	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SHELL_RS07030	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SHELL_RS07035	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SHELL_RS07045	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SHELL_RS07060	COG0255	Belongs to the universal ribosomal protein uL29 family
SHELL_RS07065	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SHELL_RS07070	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SHELL_RS07075	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SHELL_RS07095	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
SHELL_RS07100	COG0089	rRNA binding
SHELL_RS07110	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SHELL_RS07120	COG0433	COG0433 Predicted ATPase
SHELL_RS07140	COG1201	RNA secondary structure unwinding
SHELL_RS07180	COG0674	pyruvate-flavodoxin oxidoreductase activity
SHELL_RS07185	COG1013	pyruvate-flavodoxin oxidoreductase activity
SHELL_RS07205	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
SHELL_RS07220	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SHELL_RS07230	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SHELL_RS07245	COG0124	histidyl-tRNA synthetase
SHELL_RS07280	COG3842	ATPase activity
SHELL_RS07285	COG0395	ABC-type sugar transport system, permease component
SHELL_RS07290	COG1175	transmembrane transport
SHELL_RS07295	COG1653	transport
SHELL_RS07305	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SHELL_RS07360	COG1110	DNA topoisomerase II activity
SHELL_RS07385	COG0513	Belongs to the DEAD box helicase family
SHELL_RS07395	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SHELL_RS07430	COG0668	transmembrane transport
SHELL_RS07495	COG1047	Peptidyl-prolyl cis-trans
SHELL_RS07500	COG0371	Dehydrogenase
SHELL_RS07505	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SHELL_RS07510	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SHELL_RS07515	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SHELL_RS07520	COG0430	RNA-3'-phosphate cyclase activity
SHELL_RS07525	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SHELL_RS07535	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SHELL_RS07540	COG1515	deoxyribonuclease V activity
SHELL_RS07555	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SHELL_RS07565	COG0492	ferredoxin-NADP+ reductase activity
SHELL_RS07570	COG0704	Plays a role in the regulation of phosphate uptake
SHELL_RS07575	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SHELL_RS07580	COG0581	inorganic phosphate transmembrane transporter activity
SHELL_RS07600	COG0667	Aldo Keto reductase
SHELL_RS07625	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SHELL_RS07635	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SHELL_RS07650	COG0343	queuine tRNA-ribosyltransferase activity
SHELL_RS07695	COG1129	ABC transporter
SHELL_RS07700	COG1980	fructose-bisphosphate aldolase activity
SHELL_RS07765	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SHELL_RS07775	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SHELL_RS07825	COG0864	Transcriptional regulator
SHELL_RS07840	COG2264	protein methyltransferase activity
SHELL_RS07860	COG0417	DNA replication proofreading
SHELL_RS07895	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SHELL_RS07930	COG1185	polyribonucleotide nucleotidyltransferase activity
SHELL_RS07935	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
SHELL_RS08010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
SHELL_RS08010	COG0301	tRNA thio-modification
SHELL_RS08035	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SHELL_RS08080	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SHELL_RS08095	COG0105	UTP biosynthetic process
SHELL_RS08115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SHELL_RS08125	COG1304	FMN binding
SHELL_RS08130	COG1355	regulation of microtubule-based process
SHELL_RS08135	COG0052	Belongs to the universal ribosomal protein uS2 family
SHELL_RS08145	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SHELL_RS08155	COG0200	Binds to the 23S rRNA
SHELL_RS08165	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SHELL_RS08170	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SHELL_RS08175	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SHELL_RS08185	COG0051	transcription antitermination factor activity, RNA binding
SHELL_RS08190	COG2895	sulfate adenylyltransferase (ATP) activity
SHELL_RS08195	COG0049	tRNA binding
SHELL_RS08220	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SHELL_RS08225	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SHELL_RS08230	COG0085	RNA polymerase activity
SHELL_RS08245	COG4948	Mandelate Racemase Muconate Lactonizing
SHELL_RS08250	COG0546	phosphoglycolate phosphatase activity