locus-tag	class	description
SMAR_RS00010	COG0310	cobalt ion transport
SMAR_RS00025	COG1122	ATPase activity
SMAR_RS00030	COG0864	Transcriptional regulator
SMAR_RS00035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMAR_RS00055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SMAR_RS00065	COG0298	carbon dioxide binding
SMAR_RS00070	COG0383	alpha-mannosidase activity
SMAR_RS00075	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
SMAR_RS00090	COG3260	NADH ubiquinone oxidoreductase 20
SMAR_RS00105	COG2212	antiporter activity
SMAR_RS00125	COG1006	Multisubunit Na H antiporter MnhC subunit
SMAR_RS00135	COG0651	ATP synthesis coupled electron transport
SMAR_RS00145	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SMAR_RS00160	COG3608	succinylglutamate desuccinylase aspartoacylase
SMAR_RS00160	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
SMAR_RS00195	COG4172	Belongs to the ABC transporter superfamily
SMAR_RS00210	COG1592	Rubrerythrin
SMAR_RS00215	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
SMAR_RS00225	COG2033	superoxide reductase activity
SMAR_RS00235	COG1522	sequence-specific DNA binding
SMAR_RS00240	COG0351	phosphomethylpyrimidine kinase
SMAR_RS00255	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
SMAR_RS00265	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
SMAR_RS00275	COG0426	domain, Protein
SMAR_RS00285	COG0450	alkyl hydroperoxide reductase
SMAR_RS00295	COG0668	transmembrane transport
SMAR_RS00300	COG1078	dGTPase activity
SMAR_RS00320	COG1131	(ABC) transporter
SMAR_RS00325	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
SMAR_RS00340	COG0295	cytidine deaminase activity
SMAR_RS00360	COG0395	ABC-type sugar transport system, permease component
SMAR_RS00385	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
SMAR_RS00405	COG0475	glutathione-regulated potassium exporter activity
SMAR_RS00420	COG1012	belongs to the aldehyde dehydrogenase family
SMAR_RS00425	COG0438	transferase activity, transferring glycosyl groups
SMAR_RS00445	COG0395	ABC-type sugar transport system, permease component
SMAR_RS00450	COG1175	transmembrane transport
SMAR_RS00455	COG1653	transport
SMAR_RS00470	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
SMAR_RS00480	COG0513	Belongs to the DEAD box helicase family
SMAR_RS00490	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
SMAR_RS00500	COG0436	Aminotransferase
SMAR_RS00510	COG0121	glutamine amidotransferase
SMAR_RS00525	COG0778	Nitroreductase
SMAR_RS00545	COG0395	ABC-type sugar transport system, permease component
SMAR_RS00550	COG3833	ABC-type maltose transport systems, permease component
SMAR_RS00555	COG3842	ATPase activity
SMAR_RS00560	COG0463	Glycosyl transferase, family 2
SMAR_RS00570	COG1131	(ABC) transporter
SMAR_RS00575	COG0719	Fe-S assembly protein
SMAR_RS00580	COG0719	Fe-S assembly protein
SMAR_RS00590	COG0495	leucyl-tRNA aminoacylation
SMAR_RS00640	COG2095	MarC family integral membrane protein
SMAR_RS00665	COG3845	ABC transporter
SMAR_RS00670	COG4603	Belongs to the binding-protein-dependent transport system permease family
SMAR_RS00675	COG1079	Belongs to the binding-protein-dependent transport system permease family
SMAR_RS00705	COG0439	Biotin carboxylase
SMAR_RS00710	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
SMAR_RS00710	COG0574	Belongs to the PEP-utilizing enzyme family
SMAR_RS00740	COG0003	Pfam Anion-transporting ATPase
SMAR_RS00770	COG4149	molybdate abc transporter
SMAR_RS00775	COG3842	ATPase activity
SMAR_RS00830	COG1392	Phosphate transport regulator
SMAR_RS00835	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
SMAR_RS00850	COG1131	(ABC) transporter
SMAR_RS00855	COG0746	molybdenum cofactor guanylyltransferase activity
SMAR_RS00860	COG0409	Hydrogenase expression formation protein
SMAR_RS00875	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
SMAR_RS00885	COG0489	protein tyrosine kinase activity
SMAR_RS00910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
SMAR_RS00915	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
SMAR_RS00920	COG0174	glutamine synthetase
SMAR_RS00925	COG1522	sequence-specific DNA binding
SMAR_RS00930	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SMAR_RS00950	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
SMAR_RS00960	COG0095	Lipoate-protein ligase
SMAR_RS01005	COG1881	PFAM PEBP family protein
SMAR_RS01010	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SMAR_RS01025	COG1166	arginine decarboxylase activity
SMAR_RS01055	COG0303	'Molybdopterin
SMAR_RS01085	COG0402	S-adenosylhomocysteine deaminase activity
SMAR_RS01105	COG0489	protein tyrosine kinase activity
SMAR_RS01125	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SMAR_RS01140	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SMAR_RS01195	COG0167	dihydroorotate dehydrogenase activity
SMAR_RS01205	COG0126	phosphoglycerate kinase activity
SMAR_RS01215	COG0589	response to stress
SMAR_RS01220	COG2084	Dehydrogenase
SMAR_RS01235	COG0058	SHG alpha-glucan phosphorylase activity
SMAR_RS01240	COG1335	isochorismatase
SMAR_RS01245	COG0719	Fe-S assembly protein
SMAR_RS01260	COG0475	glutathione-regulated potassium exporter activity
SMAR_RS01280	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SMAR_RS01280	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SMAR_RS01285	COG1458	PINc domain ribonuclease
SMAR_RS01300	COG0446	pyridine nucleotide-disulphide oxidoreductase
SMAR_RS01310	COG0584	glycerophosphoryl diester phosphodiesterase
SMAR_RS01325	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
SMAR_RS01360	COG0444	Belongs to the ABC transporter superfamily
SMAR_RS01365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMAR_RS01370	COG0601	transmembrane transport
SMAR_RS01375	COG0747	negative chemotaxis
SMAR_RS01385	COG0436	Aminotransferase
SMAR_RS01395	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
SMAR_RS01405	COG0725	ABC transporter, periplasmic molybdate-binding protein
SMAR_RS01430	COG0733	neurotransmitter:sodium symporter activity
SMAR_RS01440	COG2095	MarC family integral membrane protein
SMAR_RS01460	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
SMAR_RS01490	COG0017	Asparaginyl-tRNA synthetase
SMAR_RS01520	COG3842	ATPase activity
SMAR_RS01525	COG0521	Mo-molybdopterin cofactor biosynthetic process
SMAR_RS01550	COG1337	RAMP superfamily
SMAR_RS01590	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
SMAR_RS01670	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
SMAR_RS01675	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
SMAR_RS01680	COG0017	Asparaginyl-tRNA synthetase
SMAR_RS01700	COG2046	Belongs to the sulfate adenylyltransferase family
SMAR_RS01710	COG0529	Catalyzes the synthesis of activated sulfate
SMAR_RS01725	COG4608	Belongs to the ABC transporter superfamily
SMAR_RS01730	COG0444	Belongs to the ABC transporter superfamily
SMAR_RS01735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMAR_RS01740	COG0601	transmembrane transport
SMAR_RS01745	COG0747	negative chemotaxis
SMAR_RS01775	COG1141	Ferredoxin
SMAR_RS01785	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SMAR_RS01800	COG1529	Aldehyde oxidase and xanthine dehydrogenase
SMAR_RS01830	COG1121	(ABC) transporter
SMAR_RS01900	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SMAR_RS01900	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMAR_RS01915	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SMAR_RS01925	COG0402	S-adenosylhomocysteine deaminase activity
SMAR_RS01945	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
SMAR_RS01970	COG1122	ATPase activity
SMAR_RS01980	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
SMAR_RS02000	COG0037	tRNA processing
SMAR_RS02005	COG0175	sulfate reduction
SMAR_RS02010	COG0563	adenylate kinase activity
SMAR_RS02040	COG1131	(ABC) transporter
SMAR_RS02080	COG4946	Tricorn protease homolog
SMAR_RS02080	COG1506	peptidase
SMAR_RS02080	COG0823	Involved in the tonB-independent uptake of proteins
SMAR_RS02090	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
SMAR_RS02100	COG5012	cobalamin binding
SMAR_RS02120	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SMAR_RS02185	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
SMAR_RS02185	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
SMAR_RS02190	COG1404	Belongs to the peptidase S8 family
SMAR_RS02220	COG0714	Associated with various cellular activities
SMAR_RS02260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMAR_RS02260	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMAR_RS02275	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
SMAR_RS02305	COG0314	molybdopterin synthase activity
SMAR_RS02315	COG0546	phosphoglycolate phosphatase activity
SMAR_RS02330	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SMAR_RS02330	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
SMAR_RS02350	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
SMAR_RS02355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
SMAR_RS02375	COG0045	succinate-CoA ligase (ADP-forming) activity
SMAR_RS02380	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
SMAR_RS02390	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
SMAR_RS02400	COG1793	dna ligase
SMAR_RS02400	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SMAR_RS02460	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
SMAR_RS02470	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
SMAR_RS02475	COG0402	S-adenosylhomocysteine deaminase activity
SMAR_RS02480	COG0180	Tryptophanyl-tRNA synthetase
SMAR_RS02485	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
SMAR_RS02495	COG0142	geranyltranstransferase activity
SMAR_RS02500	COG1342	Belongs to the UPF0251 family
SMAR_RS02510	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
SMAR_RS02525	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SMAR_RS02530	COG1899	peptidyl-lysine modification to peptidyl-hypusine
SMAR_RS02540	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SMAR_RS02540	COG0731	radical SAM domain protein
SMAR_RS02545	COG1535	isochorismatase
SMAR_RS02545	COG3433	isochorismatase activity
SMAR_RS02565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
SMAR_RS02615	COG0813	purine-nucleoside phosphorylase activity
SMAR_RS02650	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
SMAR_RS02660	COG1872	DUF167
SMAR_RS02665	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SMAR_RS02675	COG0546	phosphoglycolate phosphatase activity
SMAR_RS02720	COG0009	L-threonylcarbamoyladenylate synthase
SMAR_RS02750	COG1716	ATPase activity
SMAR_RS02765	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
SMAR_RS02770	COG0006	proline dipeptidase activity
SMAR_RS02790	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
SMAR_RS02795	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
SMAR_RS02820	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
SMAR_RS02840	COG1028	Short-chain dehydrogenase reductase Sdr
SMAR_RS02855	COG0330	HflC and HflK could
SMAR_RS02965	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
SMAR_RS02970	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
SMAR_RS03010	COG2217	Heavy metal translocating P-type atpase
SMAR_RS03015	COG0667	Aldo Keto reductase
SMAR_RS03025	COG0167	dihydroorotate dehydrogenase activity
SMAR_RS03040	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
SMAR_RS03050	COG0540	Belongs to the ATCase OTCase family
SMAR_RS03055	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
SMAR_RS03060	COG0284	orotidine-5'-phosphate decarboxylase activity
SMAR_RS03065	COG0504	CTP synthase activity
SMAR_RS03070	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
SMAR_RS03085	COG2239	Acts as a magnesium transporter
SMAR_RS03170	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
SMAR_RS03185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
SMAR_RS03210	COG0116	Belongs to the methyltransferase superfamily
SMAR_RS03210	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
SMAR_RS03215	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
SMAR_RS03235	COG2264	protein methyltransferase activity
SMAR_RS03285	COG1185	polyribonucleotide nucleotidyltransferase activity
SMAR_RS03295	COG0651	ATP synthesis coupled electron transport
SMAR_RS03300	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMAR_RS03310	COG0649	NAD binding
SMAR_RS03320	COG2212	antiporter activity
SMAR_RS03345	COG1863	multisubunit Na H antiporter MnhE subunit
SMAR_RS03355	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
SMAR_RS03365	COG0475	glutathione-regulated potassium exporter activity
SMAR_RS03390	COG0535	radical SAM domain protein
SMAR_RS03395	COG1032	radical SAM domain protein
SMAR_RS03415	COG2414	aldehyde ferredoxin oxidoreductase
SMAR_RS03425	COG0306	phosphate transporter
SMAR_RS03465	COG1028	Short-chain dehydrogenase reductase Sdr
SMAR_RS03485	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
SMAR_RS03500	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
SMAR_RS03525	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
SMAR_RS03550	COG1744	ABC transporter substrate-binding protein PnrA-like
SMAR_RS03555	COG3845	ABC transporter
SMAR_RS03560	COG4603	Belongs to the binding-protein-dependent transport system permease family
SMAR_RS03565	COG1079	Belongs to the binding-protein-dependent transport system permease family
SMAR_RS03570	COG1063	alcohol dehydrogenase
SMAR_RS03575	COG0813	purine-nucleoside phosphorylase activity
SMAR_RS03585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
SMAR_RS03610	COG2894	cell division
SMAR_RS03620	COG1486	melibiose metabolic process
SMAR_RS03640	COG2211	Major facilitator Superfamily
SMAR_RS03660	COG0585	pseudouridine synthase activity
SMAR_RS03675	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMAR_RS03685	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMAR_RS03685	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
SMAR_RS03690	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
SMAR_RS03705	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
SMAR_RS03715	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SMAR_RS03715	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
SMAR_RS03785	COG0525	valine-tRNA ligase activity
SMAR_RS03790	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
SMAR_RS03790	COG1796	DNA polymerase
SMAR_RS03825	COG0189	ligase activity
SMAR_RS03840	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
SMAR_RS03850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
SMAR_RS03865	COG0393	Putative heavy-metal-binding
SMAR_RS03910	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
SMAR_RS03965	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
SMAR_RS03995	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
SMAR_RS04010	COG0528	UMP kinase activity
SMAR_RS04015	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMAR_RS04025	COG0668	transmembrane transport
SMAR_RS04050	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
SMAR_RS04055	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
SMAR_RS04060	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
SMAR_RS04080	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SMAR_RS04105	COG0546	phosphoglycolate phosphatase activity
SMAR_RS04115	COG4948	Mandelate Racemase Muconate Lactonizing
SMAR_RS04130	COG0085	RNA polymerase activity
SMAR_RS04135	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SMAR_RS04140	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
SMAR_RS04165	COG0049	tRNA binding
SMAR_RS04170	COG2895	sulfate adenylyltransferase (ATP) activity
SMAR_RS04175	COG0051	transcription antitermination factor activity, RNA binding
SMAR_RS04185	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
SMAR_RS04190	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SMAR_RS04195	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
SMAR_RS04205	COG0200	Binds to the 23S rRNA
SMAR_RS04215	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
SMAR_RS04225	COG0052	Belongs to the universal ribosomal protein uS2 family
SMAR_RS04230	COG1355	regulation of microtubule-based process
SMAR_RS04235	COG1304	FMN binding
SMAR_RS04245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
SMAR_RS04265	COG0105	UTP biosynthetic process
SMAR_RS04280	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
SMAR_RS04320	COG2815	serine threonine protein kinase
SMAR_RS04320	COG0515	serine threonine protein kinase
SMAR_RS04325	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
SMAR_RS04330	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
SMAR_RS04425	COG1185	polyribonucleotide nucleotidyltransferase activity
SMAR_RS04430	COG1185	polyribonucleotide nucleotidyltransferase activity
SMAR_RS04465	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
SMAR_RS04500	COG0417	DNA replication proofreading
SMAR_RS04520	COG2264	protein methyltransferase activity
SMAR_RS04535	COG0864	Transcriptional regulator
SMAR_RS04540	COG0072	phenylalanine-tRNA ligase activity
SMAR_RS04540	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMAR_RS04590	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
SMAR_RS04600	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SMAR_RS04665	COG1980	fructose-bisphosphate aldolase activity
SMAR_RS04670	COG1129	ABC transporter
SMAR_RS04715	COG0343	queuine tRNA-ribosyltransferase activity
SMAR_RS04730	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMAR_RS04740	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
SMAR_RS04765	COG0667	Aldo Keto reductase
SMAR_RS04785	COG0581	inorganic phosphate transmembrane transporter activity
SMAR_RS04790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
SMAR_RS04795	COG0704	Plays a role in the regulation of phosphate uptake
SMAR_RS04800	COG0492	ferredoxin-NADP+ reductase activity
SMAR_RS04810	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
SMAR_RS04825	COG1515	deoxyribonuclease V activity
SMAR_RS04840	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SMAR_RS04845	COG0430	RNA-3'-phosphate cyclase activity
SMAR_RS04850	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SMAR_RS04855	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
SMAR_RS04860	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
SMAR_RS04865	COG0371	Dehydrogenase
SMAR_RS04870	COG1047	Peptidyl-prolyl cis-trans
SMAR_RS04910	COG0438	transferase activity, transferring glycosyl groups
SMAR_RS04945	COG0668	transmembrane transport
SMAR_RS04980	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
SMAR_RS04990	COG0513	Belongs to the DEAD box helicase family
SMAR_RS05015	COG1110	DNA topoisomerase II activity
SMAR_RS05070	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
SMAR_RS05110	COG0124	histidyl-tRNA synthetase
SMAR_RS05125	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SMAR_RS05135	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
SMAR_RS05150	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
SMAR_RS05165	COG0456	acetyltransferase
SMAR_RS05170	COG1013	pyruvate-flavodoxin oxidoreductase activity
SMAR_RS05175	COG0674	pyruvate-flavodoxin oxidoreductase activity
SMAR_RS05185	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SMAR_RS05185	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
SMAR_RS05185	COG0674	pyruvate-flavodoxin oxidoreductase activity
SMAR_RS05185	COG1013	pyruvate-flavodoxin oxidoreductase activity
SMAR_RS05215	COG1201	RNA secondary structure unwinding
SMAR_RS05260	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
SMAR_RS05270	COG0089	rRNA binding
SMAR_RS05295	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
SMAR_RS05300	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
SMAR_RS05305	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
SMAR_RS05310	COG0255	Belongs to the universal ribosomal protein uL29 family
SMAR_RS05325	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
SMAR_RS05335	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
SMAR_RS05340	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
SMAR_RS05355	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
SMAR_RS05375	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
SMAR_RS05420	COG2813	Specifically methylates the guanine in position
SMAR_RS05430	COG0671	phosphoesterase, PA-phosphatase related
SMAR_RS05435	COG1850	ribulose-bisphosphate carboxylase activity
SMAR_RS05455	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
SMAR_RS05470	COG0437	4 iron, 4 sulfur cluster binding
SMAR_RS05475	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
SMAR_RS05475	COG2111	Na H antiporter
SMAR_RS05480	COG1007	ATP synthesis coupled electron transport
SMAR_RS05490	COG0650	Formate hydrogenlyase subunit 4
SMAR_RS05495	COG3261	NADH dehydrogenase
SMAR_RS05495	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
SMAR_RS05505	COG3260	NADH ubiquinone oxidoreductase 20
SMAR_RS05515	COG2212	antiporter activity
SMAR_RS05520	COG1320	monovalent cation:proton antiporter activity
SMAR_RS05540	COG1863	multisubunit Na H antiporter MnhE subunit
SMAR_RS05545	COG0651	ATP synthesis coupled electron transport
SMAR_RS05570	COG1489	DNA binding
SMAR_RS05580	COG0477	Major facilitator Superfamily
SMAR_RS05585	COG0717	Belongs to the dCTP deaminase family
SMAR_RS05590	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
SMAR_RS05655	COG0552	protein localization to endoplasmic reticulum
SMAR_RS05670	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
SMAR_RS05675	COG0081	regulation of translation
SMAR_RS05685	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SMAR_RS05695	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SMAR_RS05710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SMAR_RS05755	COG0509	glycine decarboxylation via glycine cleavage system
SMAR_RS05760	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
SMAR_RS05770	COG0404	The glycine cleavage system catalyzes the degradation of glycine
SMAR_RS05775	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SMAR_RS05780	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
SMAR_RS05785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
SMAR_RS05795	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
SMAR_RS05815	COG1110	DNA topoisomerase II activity
SMAR_RS05820	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SMAR_RS05825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMAR_RS05830	COG1444	tRNA N-acetyltransferase activity
SMAR_RS05835	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SMAR_RS05845	COG0163	prenyltransferase activity
SMAR_RS05865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
SMAR_RS05880	COG0423	glycine-tRNA ligase activity
SMAR_RS05885	COG0010	Belongs to the arginase family
SMAR_RS05895	COG0023	Translation Initiation Factor
SMAR_RS05910	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
SMAR_RS05970	COG3842	ATPase activity
SMAR_RS05975	COG0395	ABC-type sugar transport system, permease component
SMAR_RS05980	COG1175	transmembrane transport
SMAR_RS05985	COG1653	transport
SMAR_RS06000	COG0561	phosphatase activity
SMAR_RS06020	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
SMAR_RS06025	COG1085	galactose-1-phosphate uridylyltransferase
SMAR_RS06030	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
SMAR_RS06065	COG4974	Belongs to the 'phage' integrase family
SMAR_RS06100	COG0235	Class ii aldolase
SMAR_RS06110	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
SMAR_RS06135	COG1269	ATP hydrolysis coupled proton transport
SMAR_RS06150	COG1394	ATPase activity, coupled to movement of substances
SMAR_RS06160	COG0494	nUDIX hydrolase
SMAR_RS06185	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
SMAR_RS06255	COG2414	aldehyde ferredoxin oxidoreductase
SMAR_RS06265	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
SMAR_RS06290	COG0714	Associated with various cellular activities
SMAR_RS06320	COG0656	L-ascorbic acid biosynthetic process
SMAR_RS06325	COG0730	response to heat
SMAR_RS06330	COG0405	Gamma-glutamyltransferase
SMAR_RS06355	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
SMAR_RS06360	COG0569	domain protein
SMAR_RS06380	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
SMAR_RS06380	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
SMAR_RS06385	COG2255	four-way junction helicase activity
SMAR_RS06425	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
SMAR_RS06450	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
SMAR_RS06485	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
SMAR_RS06490	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
SMAR_RS06520	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
SMAR_RS06550	COG0252	asparaginase activity
SMAR_RS06555	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
SMAR_RS06605	COG0459	protein refolding
SMAR_RS06620	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
SMAR_RS06640	COG0148	phosphopyruvate hydratase activity
SMAR_RS06660	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMAR_RS06675	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
SMAR_RS06680	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
SMAR_RS06700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMAR_RS06725	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
SMAR_RS06730	COG0076	glutamate decarboxylase activity
SMAR_RS06760	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
SMAR_RS06815	COG2078	PFAM AMMECR1 domain protein
SMAR_RS06820	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
SMAR_RS06830	COG0647	UMP catabolic process
SMAR_RS06850	COG1573	uracil-dna glycosylase
SMAR_RS06860	COG1793	dna ligase
SMAR_RS06890	COG0501	Belongs to the peptidase M48B family
SMAR_RS06905	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
SMAR_RS06915	COG0444	Belongs to the ABC transporter superfamily
SMAR_RS06920	COG4608	Belongs to the ABC transporter superfamily
SMAR_RS06935	COG0601	transmembrane transport
SMAR_RS06940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
SMAR_RS06945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
SMAR_RS06965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
SMAR_RS07000	COG1201	RNA secondary structure unwinding
SMAR_RS07010	COG0312	modulator of DNA gyrase
SMAR_RS07015	COG0312	modulator of DNA gyrase
SMAR_RS07020	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
SMAR_RS07045	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
SMAR_RS07050	COG2151	metal-sulfur cluster biosynthetic enzyme
SMAR_RS07060	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SMAR_RS07065	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
SMAR_RS07115	COG1702	phosphate starvation-inducible protein PhoH
SMAR_RS07125	COG0017	Asparaginyl-tRNA synthetase
SMAR_RS07130	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
SMAR_RS07150	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
SMAR_RS07160	COG2264	protein methyltransferase activity
SMAR_RS07170	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
SMAR_RS07185	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
SMAR_RS07205	COG1131	(ABC) transporter
SMAR_RS07230	COG2814	Major facilitator Superfamily
SMAR_RS07235	COG2723	6-phospho-beta-galactosidase activity
SMAR_RS07240	COG1449	Belongs to the glycosyl hydrolase 57 family
SMAR_RS07245	COG0297	glycogen (starch) synthase activity
SMAR_RS07295	COG1136	(ABC) transporter
SMAR_RS07300	COG1136	(ABC) transporter
SMAR_RS07305	COG0577	efflux transmembrane transporter activity
SMAR_RS07305	COG1136	(ABC) transporter
SMAR_RS07360	COG0714	Associated with various cellular activities
SMAR_RS07415	COG4770	biotin carboxylase activity
SMAR_RS07430	COG0475	glutathione-regulated potassium exporter activity
SMAR_RS07440	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
SMAR_RS07440	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
SMAR_RS07465	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
SMAR_RS07470	COG1136	(ABC) transporter
SMAR_RS07480	COG1136	(ABC) transporter
SMAR_RS07480	COG0577	efflux transmembrane transporter activity
SMAR_RS07485	COG0534	Mate efflux family protein
SMAR_RS07500	COG1013	pyruvate-flavodoxin oxidoreductase activity
SMAR_RS07505	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
SMAR_RS07520	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
SMAR_RS07530	COG0674	pyruvate-flavodoxin oxidoreductase activity
SMAR_RS07535	COG1013	pyruvate-flavodoxin oxidoreductase activity
SMAR_RS07555	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
SMAR_RS07560	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
SMAR_RS07570	COG1574	metal-dependent hydrolase with the TIM-barrel fold
SMAR_RS07595	COG0445	tRNA wobble uridine modification
SMAR_RS07610	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
SMAR_RS07675	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
SMAR_RS07720	COG1994	Peptidase M50
SMAR_RS07725	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
SMAR_RS07735	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
SMAR_RS07735	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
SMAR_RS07740	COG0312	modulator of DNA gyrase
SMAR_RS07745	COG0312	modulator of DNA gyrase
SMAR_RS07760	COG0513	Belongs to the DEAD box helicase family
SMAR_RS07805	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
SMAR_RS07840	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
SMAR_RS07870	COG1446	asparaginase
SMAR_RS07885	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
SMAR_RS07905	COG1301	dicarboxylic acid transport
SMAR_RS08000	COG0765	amino acid transport
SMAR_RS08020	COG1881	PFAM PEBP family protein
SMAR_RS08080	COG3842	ATPase activity
SMAR_RS08155	COG0303	'Molybdopterin
SMAR_RS08230	COG0315	cyclic pyranopterin monophosphate synthase activity
SMAR_RS08235	COG0018	arginyl-trna synthetase
SMAR_RS08255	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
SMAR_RS08270	COG0303	'Molybdopterin
SMAR_RS08285	COG0598	Magnesium transport protein CorA
SMAR_RS08290	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues