locus-tag	class	description
GH266_RS00010	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GH266_RS00015	COG0730	response to heat
GH266_RS00040	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
GH266_RS00055	COG2205	protein histidine kinase activity
GH266_RS00060	COG1573	uracil-dna glycosylase
GH266_RS00065	COG2897	thiosulfate sulfurtransferase activity
GH266_RS00070	COG1522	sequence-specific DNA binding
GH266_RS00090	COG2084	Dehydrogenase
GH266_RS00100	COG0583	DNA-binding transcription factor activity
GH266_RS00120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GH266_RS00125	COG0303	'Molybdopterin
GH266_RS00130	COG1763	Mo-molybdopterin cofactor biosynthetic process
GH266_RS00135	COG0746	molybdenum cofactor guanylyltransferase activity
GH266_RS00140	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GH266_RS00170	COG3383	formate dehydrogenase (NAD+) activity
GH266_RS00175	COG0437	4 iron, 4 sulfur cluster binding
GH266_RS00230	COG2814	Major facilitator Superfamily
GH266_RS00235	COG2132	Multicopper oxidase
GH266_RS00265	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GH266_RS00285	COG1376	ErfK ybiS ycfS ynhG family protein
GH266_RS00290	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
GH266_RS00290	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
GH266_RS00300	COG3038	cytochrome b561
GH266_RS00305	COG2353	YceI-like domain
GH266_RS00310	COG0625	glutathione transferase activity
GH266_RS00315	COG0625	glutathione transferase activity
GH266_RS00320	COG2373	Large extracellular alpha-helical protein
GH266_RS00325	COG4953	penicillin-binding protein 1C
GH266_RS00330	COG2267	carboxylic ester hydrolase activity
GH266_RS00340	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GH266_RS00355	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GH266_RS00360	COG1381	Involved in DNA repair and RecF pathway recombination
GH266_RS00365	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GH266_RS00370	COG0571	ribonuclease III activity
GH266_RS00375	COG0681	Belongs to the peptidase S26 family
GH266_RS00380	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GH266_RS00395	COG1758	RNA polymerase activity
GH266_RS00405	COG1573	uracil-dna glycosylase
GH266_RS00415	COG0471	metal ion transport
GH266_RS00415	COG3273	potassium ion transport
GH266_RS00425	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GH266_RS00435	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GH266_RS00440	COG0113	porphobilinogen synthase activity
GH266_RS00445	COG1960	acyl-CoA dehydrogenase activity
GH266_RS00465	COG1846	Transcriptional regulator
GH266_RS00470	COG2989	Protein conserved in bacteria
GH266_RS00480	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GH266_RS00485	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GH266_RS00490	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GH266_RS00490	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GH266_RS00500	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GH266_RS00505	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GH266_RS00510	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
GH266_RS00515	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GH266_RS00530	COG0416	fatty acid biosynthetic process
GH266_RS00535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GH266_RS00540	COG0776	regulation of translation
GH266_RS00630	COG1612	heme a metabolic process
GH266_RS00650	COG1832	CoA-binding protein
GH266_RS00655	COG1024	Enoyl-CoA hydratase
GH266_RS00665	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GH266_RS00670	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GH266_RS00685	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GH266_RS00695	COG3243	poly(R)-hydroxyalkanoic acid synthase
GH266_RS00705	COG0436	Aminotransferase
GH266_RS00715	COG1494	fructose-1,6-bisphosphatase
GH266_RS00755	COG0446	pyridine nucleotide-disulphide oxidoreductase
GH266_RS00755	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GH266_RS00770	COG0288	reversible hydration of carbon dioxide
GH266_RS00790	COG0259	pyridoxamine-phosphate oxidase activity
GH266_RS00800	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GH266_RS00805	COG2877	3-deoxy-8-phosphooctulonate synthase activity
GH266_RS00810	COG0148	phosphopyruvate hydratase activity
GH266_RS00850	COG2301	Belongs to the HpcH HpaI aldolase family
GH266_RS00860	COG0679	Auxin Efflux Carrier
GH266_RS00870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GH266_RS00880	COG1183	phosphatidylcholine synthase activity
GH266_RS00890	COG0583	DNA-binding transcription factor activity
GH266_RS00895	COG2351	hydroxyisourate hydrolase activity
GH266_RS00905	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GH266_RS00910	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GH266_RS00915	COG1129	ABC transporter
GH266_RS00935	COG1396	sequence-specific DNA binding
GH266_RS00945	COG5001	Diguanylate cyclase
GH266_RS00945	COG3300	MHYT domain
GH266_RS00955	COG2137	regulation of response to DNA damage stimulus
GH266_RS00965	COG0084	hydrolase, TatD family'
GH266_RS00970	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GH266_RS00980	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GH266_RS01010	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GH266_RS01105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GH266_RS01130	COG0546	phosphoglycolate phosphatase activity
GH266_RS01160	COG1228	amidohydrolase
GH266_RS01205	COG0343	queuine tRNA-ribosyltransferase activity
GH266_RS01210	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GH266_RS01230	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GH266_RS01245	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GH266_RS01250	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GH266_RS01255	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GH266_RS01260	COG1309	transcriptional regulator
GH266_RS01265	COG1028	Short-chain dehydrogenase reductase Sdr
GH266_RS01300	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GH266_RS01305	COG2095	MarC family integral membrane protein
GH266_RS01310	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GH266_RS01325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GH266_RS01335	COG0747	negative chemotaxis
GH266_RS01340	COG5598	trimethylamine methyltransferase
GH266_RS01350	COG0583	DNA-binding transcription factor activity
GH266_RS01360	COG2115	Belongs to the xylose isomerase family
GH266_RS01365	COG1070	Carbohydrate kinase
GH266_RS01385	COG3956	TIGRFAM MazG family protein
GH266_RS01390	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GH266_RS01395	COG1923	regulation of RNA biosynthetic process
GH266_RS01400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GH266_RS01405	COG0569	domain protein
GH266_RS01410	COG2204	response regulator
GH266_RS01415	COG5000	phosphorelay sensor kinase activity
GH266_RS01420	COG2204	response regulator
GH266_RS01425	COG3852	Histidine kinase
GH266_RS01435	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GH266_RS01435	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GH266_RS01440	COG1546	Belongs to the CinA family
GH266_RS01440	COG1058	Belongs to the CinA family
GH266_RS01455	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GH266_RS01465	COG2261	transglycosylase associated protein
GH266_RS01475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GH266_RS01480	COG0508	dehydrogenase complex catalyzes the overall conversion of
GH266_RS01485	COG0508	dehydrogenase complex catalyzes the overall conversion of
GH266_RS01485	COG0022	dehydrogenase e1 component
GH266_RS01490	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GH266_RS01500	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GH266_RS01505	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
GH266_RS01545	COG0446	pyridine nucleotide-disulphide oxidoreductase
GH266_RS01555	COG3258	Cytochrome c
GH266_RS01560	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GH266_RS01565	COG0737	Belongs to the 5'-nucleotidase family
GH266_RS01590	COG0785	Cytochrome C biogenesis protein
GH266_RS01600	COG0640	Transcriptional regulator
GH266_RS01610	COG0589	response to stress
GH266_RS01650	COG0504	CTP synthase activity
GH266_RS01660	COG0149	triose-phosphate isomerase activity
GH266_RS01670	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GH266_RS01685	COG0303	'Molybdopterin
GH266_RS01690	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GH266_RS01705	COG0372	Belongs to the citrate synthase family
GH266_RS01710	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GH266_RS01720	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GH266_RS01725	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GH266_RS01730	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GH266_RS01735	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GH266_RS01740	COG0750	zinc metalloprotease
GH266_RS01745	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GH266_RS01755	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GH266_RS01760	COG0233	cytoplasmic translational termination
GH266_RS01770	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GH266_RS01775	COG0052	Belongs to the universal ribosomal protein uS2 family
GH266_RS01780	COG0587	DNA-directed DNA polymerase activity
GH266_RS01790	COG1136	(ABC) transporter
GH266_RS01800	COG0442	prolyl-tRNA aminoacylation
GH266_RS01810	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GH266_RS01815	COG0668	transmembrane transport
GH266_RS01820	COG1562	ergosterol biosynthetic process
GH266_RS01855	COG0525	valine-tRNA ligase activity
GH266_RS01870	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GH266_RS01900	COG1007	ATP synthesis coupled electron transport
GH266_RS01915	COG0713	ATP synthesis coupled electron transport
GH266_RS01925	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GH266_RS01935	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
GH266_RS01945	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
GH266_RS01955	COG0649	NAD binding
GH266_RS01965	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GH266_RS01970	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GH266_RS01995	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
GH266_RS02010	COG0805	protein transport
GH266_RS02015	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GH266_RS02020	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GH266_RS02025	COG3842	ATPase activity
GH266_RS02030	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GH266_RS02035	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GH266_RS02040	COG1472	Belongs to the glycosyl hydrolase 3 family
GH266_RS02050	COG0018	arginyl-trna synthetase
GH266_RS02055	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GH266_RS02060	COG0316	Belongs to the HesB IscA family
GH266_RS02090	COG0187	DNA topoisomerase II activity
GH266_RS02105	COG0513	Belongs to the DEAD box helicase family
GH266_RS02110	COG3706	GGDEF domain
GH266_RS02120	COG1737	Transcriptional regulator
GH266_RS02125	COG1879	ABC-type sugar transport system periplasmic component
GH266_RS02130	COG1172	Belongs to the binding-protein-dependent transport system permease family
GH266_RS02150	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GH266_RS02170	COG0348	domain, Protein
GH266_RS02180	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GH266_RS02190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GH266_RS02210	COG4459	periplasmic nitrate reductase
GH266_RS02220	COG3062	negative regulation of establishment of protein localization
GH266_RS02235	COG3005	denitrification pathway
GH266_RS02245	COG1686	Belongs to the peptidase S11 family
GH266_RS02250	COG2200	EAL domain
GH266_RS02255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GH266_RS02270	COG1132	(ABC) transporter
GH266_RS02280	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GH266_RS02290	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GH266_RS02300	COG0628	permease
GH266_RS02305	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GH266_RS02310	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GH266_RS02325	COG0243	molybdopterin cofactor binding
GH266_RS02330	COG0105	UTP biosynthetic process
GH266_RS02355	COG3842	ATPase activity
GH266_RS02360	COG0395	ABC-type sugar transport system, permease component
GH266_RS02365	COG1175	transmembrane transport
GH266_RS02375	COG0305	Participates in initiation and elongation during chromosome replication
GH266_RS02380	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GH266_RS02390	COG1286	toxin biosynthetic process
GH266_RS02395	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GH266_RS02400	COG4221	oxidoreductase activity
GH266_RS02405	COG1183	phosphatidylcholine synthase activity
GH266_RS02410	COG0688	phosphatidylethanolamine metabolic process
GH266_RS02415	COG5265	(ABC) transporter
GH266_RS02420	COG0640	Transcriptional regulator
GH266_RS02425	COG2962	Rard protein
GH266_RS02430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GH266_RS02440	COG2852	Protein conserved in bacteria
GH266_RS02445	COG0215	cysteine-tRNA ligase activity
GH266_RS02460	COG0640	Transcriptional regulator
GH266_RS02465	COG3045	CreA protein
GH266_RS02505	COG0745	RESPONSE REGULATOR receiver
GH266_RS02510	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GH266_RS02525	COG0316	Belongs to the HesB IscA family
GH266_RS02530	COG2151	metal-sulfur cluster biosynthetic enzyme
GH266_RS02535	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GH266_RS02540	COG0719	Fe-S assembly protein
GH266_RS02545	COG0396	ATPase activity
GH266_RS02550	COG0719	Fe-S assembly protein
GH266_RS02555	COG1104	cysteine desulfurase activity
GH266_RS02560	COG2945	thiolester hydrolase activity
GH266_RS02565	COG0546	phosphoglycolate phosphatase activity
GH266_RS02585	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GH266_RS02590	COG5002	protein histidine kinase activity
GH266_RS02600	COG1126	abc transporter atp-binding protein
GH266_RS02605	COG0765	amino acid transport
GH266_RS02610	COG4597	amino acid ABC transporter
GH266_RS02615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GH266_RS02620	COG0626	cystathionine gamma-synthase activity
GH266_RS02635	COG1283	sodium-dependent phosphate transmembrane transporter activity
GH266_RS02650	COG2515	1-aminocyclopropane-1-carboxylate deaminase
GH266_RS02670	COG3237	CsbD-like
GH266_RS02680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GH266_RS02705	COG2199	diguanylate cyclase activity
GH266_RS02705	COG2203	Gaf domain
GH266_RS02720	COG1278	Cold shock
GH266_RS02740	COG1238	metal cluster binding
GH266_RS02750	COG0747	negative chemotaxis
GH266_RS02755	COG0601	transmembrane transport
GH266_RS02760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GH266_RS02765	COG0444	Belongs to the ABC transporter superfamily
GH266_RS02770	COG4608	Belongs to the ABC transporter superfamily
GH266_RS02775	COG4948	Mandelate Racemase Muconate Lactonizing
GH266_RS02800	COG0745	RESPONSE REGULATOR receiver
GH266_RS02805	COG0642	Histidine kinase
GH266_RS02835	COG1175	transmembrane transport
GH266_RS02875	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GH266_RS02895	COG0776	regulation of translation
GH266_RS02900	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GH266_RS02905	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GH266_RS02910	COG0740	serine-type endopeptidase activity
GH266_RS02915	COG0544	peptidyl-prolyl cis-trans isomerase activity
GH266_RS02925	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GH266_RS02925	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GH266_RS02935	COG0347	Belongs to the P(II) protein family
GH266_RS02940	COG0174	glutamine synthetase
GH266_RS02950	COG0488	(ABC) transporter
GH266_RS02975	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GH266_RS02985	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GH266_RS03005	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GH266_RS03010	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GH266_RS03015	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GH266_RS03020	COG0194	GDP metabolic process
GH266_RS03025	COG1561	YicC-like family, N-terminal region
GH266_RS03030	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GH266_RS03035	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GH266_RS03040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GH266_RS03050	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GH266_RS03055	COG0360	Binds together with S18 to 16S ribosomal RNA
GH266_RS03060	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GH266_RS03065	COG0359	binds to the 23S rRNA
GH266_RS03070	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GH266_RS03080	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GH266_RS03085	COG2833	Protein of unknown function (DUF455)
GH266_RS03090	COG0739	heme binding
GH266_RS03100	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GH266_RS03105	COG0860	N-Acetylmuramoyl-L-alanine amidase
GH266_RS03110	COG1530	ribonuclease E activity
GH266_RS03120	COG0436	Aminotransferase
GH266_RS03135	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GH266_RS03140	COG0511	ligase activity, forming carbon-carbon bonds
GH266_RS03150	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GH266_RS03155	COG1192	Involved in chromosome partitioning
GH266_RS03160	COG0179	Fumarylacetoacetate (FAA) hydrolase
GH266_RS03175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GH266_RS03195	COG1618	nucleotide phosphatase activity, acting on free nucleotides
GH266_RS03195	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GH266_RS03210	COG2031	fatty acid transporter
GH266_RS03225	COG1846	Transcriptional regulator
GH266_RS03255	COG1733	regulation of RNA biosynthetic process
GH266_RS03280	COG1960	acyl-CoA dehydrogenase activity
GH266_RS03285	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GH266_RS03290	COG0583	DNA-binding transcription factor activity
GH266_RS03300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GH266_RS03310	COG2205	protein histidine kinase activity
GH266_RS03315	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
GH266_RS03325	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
GH266_RS03360	COG0625	glutathione transferase activity
GH266_RS03370	COG1253	flavin adenine dinucleotide binding
GH266_RS03385	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GH266_RS03410	COG3239	Fatty acid desaturase
GH266_RS03440	COG3811	Belongs to the UPF0386 family
GH266_RS03445	COG1280	lysine exporter protein (LysE YggA)
GH266_RS03460	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GH266_RS03475	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GH266_RS03490	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GH266_RS03495	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GH266_RS03515	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GH266_RS03520	COG0758	DNA mediated transformation
GH266_RS03525	COG1960	acyl-CoA dehydrogenase activity
GH266_RS03545	COG3800	Transcriptional regulator
GH266_RS03545	COG1396	sequence-specific DNA binding
GH266_RS03550	COG1268	BioY protein
GH266_RS03555	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GH266_RS03570	COG0439	Biotin carboxylase
GH266_RS03580	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GH266_RS03585	COG0557	exoribonuclease II activity
GH266_RS03600	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GH266_RS03615	COG0745	RESPONSE REGULATOR receiver
GH266_RS03615	COG3706	GGDEF domain
GH266_RS03620	COG0784	Response regulator, receiver
GH266_RS03635	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GH266_RS03640	COG1802	Transcriptional regulator
GH266_RS03645	COG1446	asparaginase
GH266_RS03650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GH266_RS03660	COG0251	oxidation-reduction process
GH266_RS03675	COG0537	adenosine 5'-monophosphoramidase activity
GH266_RS03700	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GH266_RS03710	COG1686	Belongs to the peptidase S11 family
GH266_RS03715	COG0484	heat shock protein binding
GH266_RS03725	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GH266_RS03750	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GH266_RS03755	COG0625	glutathione transferase activity
GH266_RS03810	COG0697	spore germination
GH266_RS03815	COG0778	Nitroreductase
GH266_RS03845	COG0798	PFAM Bile acid sodium symporter
GH266_RS03865	COG4106	trans-aconitate 2-methyltransferase activity
GH266_RS03885	COG2847	Copper chaperone PCu(A)C
GH266_RS03900	COG1522	sequence-specific DNA binding
GH266_RS03920	COG1126	abc transporter atp-binding protein
GH266_RS03930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GH266_RS03950	COG1735	metal-dependent hydrolase with the TIM-barrel fold
GH266_RS03955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GH266_RS03965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GH266_RS03970	COG0251	oxidation-reduction process
GH266_RS03990	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GH266_RS03995	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GH266_RS04025	COG0028	Belongs to the TPP enzyme family
GH266_RS04090	COG1704	LemA family
GH266_RS04105	COG0519	Catalyzes the synthesis of GMP from XMP
GH266_RS04105	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GH266_RS04115	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GH266_RS04115	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GH266_RS04130	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
GH266_RS04155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GH266_RS04185	COG1022	Amp-dependent synthetase and ligase
GH266_RS04190	COG0183	Belongs to the thiolase family
GH266_RS04195	COG1250	3-hydroxyacyl-CoA dehydrogenase
GH266_RS04195	COG1024	Enoyl-CoA hydratase
GH266_RS04200	COG1024	Enoyl-CoA hydratase
GH266_RS04205	COG2070	2-Nitropropane dioxygenase
GH266_RS04210	COG3668	Plasmid stabilization system
GH266_RS04215	COG3609	addiction module antidote protein, CC2985 family
GH266_RS04235	COG0346	lactoylglutathione lyase activity
GH266_RS04240	COG0400	carboxylic ester hydrolase activity
GH266_RS04245	COG1741	Belongs to the pirin family
GH266_RS04250	COG2207	Transcriptional regulator
GH266_RS04255	COG1335	isochorismatase
GH266_RS04290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GH266_RS04295	COG1028	Short-chain dehydrogenase reductase Sdr
GH266_RS04300	COG1024	Enoyl-CoA hydratase
GH266_RS04305	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
GH266_RS04355	COG0583	DNA-binding transcription factor activity
GH266_RS04405	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GH266_RS04420	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GH266_RS04460	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GH266_RS04465	COG0066	3-isopropylmalate dehydratase activity
GH266_RS04490	COG1053	succinate dehydrogenase
GH266_RS04505	COG2855	membrane
GH266_RS04510	COG2423	ornithine cyclodeaminase activity
GH266_RS04515	COG0629	single-stranded DNA binding
GH266_RS04520	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GH266_RS04535	COG0740	serine-type endopeptidase activity
GH266_RS04550	COG2378	regulation of single-species biofilm formation
GH266_RS04560	COG2308	Evidence 4 Homologs of previously reported genes of
GH266_RS04570	COG1305	Transglutaminase-like
GH266_RS04580	COG0577	efflux transmembrane transporter activity
GH266_RS04580	COG1136	(ABC) transporter
GH266_RS04635	COG0251	oxidation-reduction process
GH266_RS04640	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GH266_RS04650	COG2239	Acts as a magnesium transporter
GH266_RS04660	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GH266_RS04665	COG0321	lipoyl(octanoyl) transferase activity
GH266_RS04670	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GH266_RS04675	COG1752	Esterase of the alpha-beta hydrolase superfamily
GH266_RS04675	COG1752	Esterase of the alpha-beta hydrolase superfamily
GH266_RS04680	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GH266_RS04685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GH266_RS04690	COG0203	ribosomal protein L17
GH266_RS04695	COG0202	RNA polymerase activity
GH266_RS04700	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GH266_RS04705	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GH266_RS04710	COG0563	adenylate kinase activity
GH266_RS04715	COG0201	protein transport
GH266_RS04720	COG0200	Binds to the 23S rRNA
GH266_RS04725	COG1841	ribosomal large subunit assembly
GH266_RS04735	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GH266_RS04740	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GH266_RS04745	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GH266_RS04750	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GH266_RS04755	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GH266_RS04760	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GH266_RS04765	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GH266_RS04770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GH266_RS04780	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GH266_RS04785	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GH266_RS04790	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GH266_RS04800	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GH266_RS04805	COG0089	rRNA binding
GH266_RS04810	COG0088	Forms part of the polypeptide exit tunnel
GH266_RS04815	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GH266_RS04820	COG0051	transcription antitermination factor activity, RNA binding
GH266_RS04825	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GH266_RS04830	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GH266_RS04835	COG0049	tRNA binding
GH266_RS04845	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GH266_RS04850	COG0085	RNA polymerase activity
GH266_RS04855	COG0222	ribosome binding
GH266_RS04860	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GH266_RS04865	COG0081	regulation of translation
GH266_RS04870	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GH266_RS04890	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GH266_RS04910	COG4771	TonB-dependent receptor
GH266_RS04915	COG1858	cytochrome C peroxidase
GH266_RS05180	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GH266_RS05200	COG2010	Cytochrome c
GH266_RS05205	COG1324	tolerance protein
GH266_RS05210	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GH266_RS05240	COG2301	Belongs to the HpcH HpaI aldolase family
GH266_RS05265	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GH266_RS05275	COG0189	ligase activity
GH266_RS05285	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GH266_RS05295	COG0302	gtp cyclohydrolase
GH266_RS05300	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GH266_RS05315	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
GH266_RS05375	COG2267	carboxylic ester hydrolase activity
GH266_RS05390	COG1546	Belongs to the CinA family
GH266_RS05390	COG1058	Belongs to the CinA family
GH266_RS05395	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
GH266_RS05400	COG1388	LysM domain
GH266_RS05400	COG1376	ErfK ybiS ycfS ynhG family protein
GH266_RS05405	COG1489	DNA binding
GH266_RS05410	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GH266_RS05415	COG1285	pathogenesis
GH266_RS05425	COG0024	Methionine aminopeptidase
GH266_RS05430	COG2003	Belongs to the UPF0758 family
GH266_RS05440	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GH266_RS05450	COG0386	Belongs to the glutathione peroxidase family
GH266_RS05455	COG0415	Belongs to the DNA photolyase family
GH266_RS05465	COG5001	Diguanylate cyclase
GH266_RS05475	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GH266_RS05475	COG0574	Belongs to the PEP-utilizing enzyme family
GH266_RS05485	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GH266_RS05495	COG0142	geranyltranstransferase activity
GH266_RS05510	COG5425	PFAM Usg family protein
GH266_RS05525	COG1346	cytolysis
GH266_RS05540	COG1376	ErfK ybiS ycfS ynhG family protein
GH266_RS05560	COG0411	ABC transporter
GH266_RS05580	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GH266_RS05595	COG1522	sequence-specific DNA binding
GH266_RS05605	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
GH266_RS05605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GH266_RS05630	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GH266_RS05670	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GH266_RS05680	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GH266_RS05685	COG0047	phosphoribosylformylglycinamidine synthase activity
GH266_RS05695	COG2207	Transcriptional regulator
GH266_RS05710	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GH266_RS05720	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GH266_RS05730	COG0443	Heat shock 70 kDa protein
GH266_RS05735	COG0037	tRNA processing
GH266_RS05740	COG3706	GGDEF domain
GH266_RS05750	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GH266_RS05770	COG4251	negative regulation of phosphorylation
GH266_RS05780	COG0538	isocitrate dehydrogenase activity
GH266_RS05800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GH266_RS05805	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GH266_RS05810	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GH266_RS05815	COG0588	phosphoglycerate mutase activity
GH266_RS05820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GH266_RS05825	COG2313	pseudouridylate synthase activity
GH266_RS05850	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GH266_RS05855	COG4589	Belongs to the CDS family
GH266_RS05875	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GH266_RS05880	COG1684	flagellar biosynthetic protein fliR
GH266_RS05885	COG1987	bacterial-type flagellum assembly
GH266_RS05890	COG1677	Flagellar hook-basal body complex protein FliE
GH266_RS05895	COG1558	bacterial-type flagellum-dependent cell motility
GH266_RS05910	COG1338	Plays a role in the flagellum-specific transport system
GH266_RS05940	COG4786	Flagellar basal body rod
GH266_RS05945	COG4786	Flagellar basal body rod
GH266_RS05955	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GH266_RS05960	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
GH266_RS05965	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GH266_RS05975	COG1706	bacterial-type flagellum-dependent cell motility
GH266_RS05980	COG3951	Flagellar rod assembly protein muramidase FlgJ
GH266_RS06000	COG1083	cytidylyl-transferase
GH266_RS06005	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GH266_RS06015	COG2089	acid synthase
GH266_RS06020	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GH266_RS06035	COG5443	negative regulation of bacterial-type flagellum assembly
GH266_RS06040	COG5442	Flagellar protein FlaF
GH266_RS06060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GH266_RS06075	COG3106	COG3106 Predicted ATPase
GH266_RS06080	COG3768	UPF0283 membrane protein
GH266_RS06090	COG0840	transmembrane signaling receptor activity
GH266_RS06135	COG2207	Transcriptional regulator
GH266_RS06155	COG0633	Ferredoxin
GH266_RS06185	COG3218	ABC-type transport auxiliary lipoprotein component
GH266_RS06185	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GH266_RS06190	COG1127	ABC transporter
GH266_RS06205	COG4948	Mandelate Racemase Muconate Lactonizing
GH266_RS06210	COG2814	Major facilitator Superfamily
GH266_RS06230	COG0438	transferase activity, transferring glycosyl groups
GH266_RS06240	COG1028	Short-chain dehydrogenase reductase Sdr
GH266_RS06245	COG2067	long-chain fatty acid transport protein
GH266_RS06270	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GH266_RS06280	COG0697	spore germination
GH266_RS06290	COG0697	spore germination
GH266_RS06295	COG1910	domain protein
GH266_RS06300	COG0318	PFAM AMP-dependent synthetase and ligase
GH266_RS06305	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GH266_RS06335	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GH266_RS06340	COG0129	dihydroxy-acid dehydratase activity
GH266_RS06360	COG0166	Belongs to the GPI family
GH266_RS06375	COG0686	Belongs to the AlaDH PNT family
GH266_RS06380	COG1522	sequence-specific DNA binding
GH266_RS06385	COG0745	RESPONSE REGULATOR receiver
GH266_RS06405	COG0384	phenazine biosynthesis protein PhzF
GH266_RS06415	COG0693	protein deglycase activity
GH266_RS06430	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GH266_RS06440	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GH266_RS06450	COG2153	protein acetylation
GH266_RS06455	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GH266_RS06465	COG0330	HflC and HflK could
GH266_RS06470	COG0330	HflC and HflK could
GH266_RS06475	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
GH266_RS06485	COG3830	Belongs to the UPF0237 family
GH266_RS06485	COG0560	Phosphoserine phosphatase
GH266_RS06490	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GH266_RS06500	COG3311	Transcriptional regulator
GH266_RS06510	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GH266_RS06520	COG0028	Belongs to the TPP enzyme family
GH266_RS06535	COG1131	(ABC) transporter
GH266_RS06540	COG0842	Transport permease protein
GH266_RS06545	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GH266_RS06580	COG0277	FAD linked oxidase domain protein
GH266_RS06595	COG0006	proline dipeptidase activity
GH266_RS06605	COG2264	protein methyltransferase activity
GH266_RS06610	COG0210	DNA helicase
GH266_RS06620	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GH266_RS06625	COG0497	DNA recombination
GH266_RS06630	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GH266_RS06640	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GH266_RS06645	COG0849	cell division
GH266_RS06650	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GH266_RS06655	COG1181	Belongs to the D-alanine--D-alanine ligase family
GH266_RS06665	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GH266_RS06670	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GH266_RS06680	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GH266_RS06685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GH266_RS06690	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GH266_RS06705	COG0275	rRNA processing
GH266_RS06710	COG2001	Belongs to the MraZ family
GH266_RS06735	COG3023	N-Acetylmuramoyl-L-alanine amidase
GH266_RS06740	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GH266_RS06745	COG1028	Short-chain dehydrogenase reductase Sdr
GH266_RS06750	COG0114	fumarate hydratase activity
GH266_RS06755	COG5001	Diguanylate cyclase
GH266_RS06770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GH266_RS06795	COG0840	transmembrane signaling receptor activity
GH266_RS06795	COG0840	transmembrane signaling receptor activity
GH266_RS06830	COG0154	amidase activity
GH266_RS06840	COG0668	transmembrane transport
GH266_RS06845	COG2226	methyltransferase
GH266_RS06870	COG2755	lipolytic protein G-D-S-L family
GH266_RS06870	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GH266_RS06875	COG0583	DNA-binding transcription factor activity
GH266_RS06930	COG5642	Protein of unknown function (DUF2384)
GH266_RS06940	COG2199	diguanylate cyclase activity
GH266_RS06945	COG3034	peptidoglycan biosynthetic process
GH266_RS06950	COG0789	Transcriptional regulator
GH266_RS06975	COG0183	Belongs to the thiolase family
GH266_RS06980	COG1028	Short-chain dehydrogenase reductase Sdr
GH266_RS06990	COG0411	ABC transporter
GH266_RS07000	COG0559	Belongs to the binding-protein-dependent transport system permease family
GH266_RS07010	COG0371	Dehydrogenase
GH266_RS07020	COG3958	Transketolase
GH266_RS07025	COG3959	Transketolase, thiamine diphosphate binding domain
GH266_RS07050	COG1960	acyl-CoA dehydrogenase activity
GH266_RS07060	COG1024	Enoyl-CoA hydratase
GH266_RS07065	COG2186	Transcriptional regulator
GH266_RS07090	COG1028	Short-chain dehydrogenase reductase Sdr
GH266_RS07095	COG1028	Short-chain dehydrogenase reductase Sdr
GH266_RS07110	COG4585	Histidine kinase
GH266_RS07130	COG0628	permease
GH266_RS07135	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GH266_RS07140	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GH266_RS07160	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GH266_RS07165	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GH266_RS07175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GH266_RS07190	COG1309	transcriptional regulator
GH266_RS07195	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GH266_RS07210	COG0505	Belongs to the CarA family
GH266_RS07215	COG0789	Transcriptional regulator
GH266_RS07235	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GH266_RS07245	COG1522	sequence-specific DNA binding
GH266_RS07255	COG0492	ferredoxin-NADP+ reductase activity
GH266_RS07260	COG0583	DNA-binding transcription factor activity
GH266_RS07265	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GH266_RS07270	COG0477	Major facilitator Superfamily
GH266_RS07275	COG2133	pyrroloquinoline quinone binding
GH266_RS07280	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GH266_RS07335	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
GH266_RS07350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GH266_RS07355	COG1278	Cold shock
GH266_RS07365	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
GH266_RS07390	COG0625	glutathione transferase activity
GH266_RS07405	COG0530	calcium, potassium:sodium antiporter activity
GH266_RS07410	COG1028	Short-chain dehydrogenase reductase Sdr
GH266_RS07420	COG1435	thymidine kinase activity
GH266_RS07435	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GH266_RS07445	COG0314	molybdopterin synthase activity
GH266_RS07450	COG2814	Major facilitator Superfamily
GH266_RS07455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GH266_RS07460	COG1846	Transcriptional regulator
GH266_RS07465	COG0745	RESPONSE REGULATOR receiver
GH266_RS07470	COG2205	protein histidine kinase activity
GH266_RS07475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GH266_RS07500	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GH266_RS07525	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GH266_RS07535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GH266_RS07555	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GH266_RS07560	COG0193	aminoacyl-tRNA hydrolase activity
GH266_RS07575	COG2030	dehydratase
GH266_RS07590	COG0456	acetyltransferase
GH266_RS07595	COG0778	Nitroreductase
GH266_RS07600	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GH266_RS07605	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GH266_RS07610	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GH266_RS07610	COG2857	Cytochrome c1
GH266_RS07615	COG2857	Cytochrome c1
GH266_RS07615	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GH266_RS07625	COG1132	(ABC) transporter
GH266_RS07635	COG1132	(ABC) transporter
GH266_RS07640	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GH266_RS07645	COG0408	coproporphyrinogen oxidase activity
GH266_RS07650	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GH266_RS07665	COG0494	nUDIX hydrolase
GH266_RS07675	COG0714	Associated with various cellular activities
GH266_RS07700	COG0435	Glutathione S-transferase
GH266_RS07730	COG2957	Belongs to the agmatine deiminase family
GH266_RS07740	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GH266_RS07745	COG2204	response regulator
GH266_RS07750	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GH266_RS07760	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GH266_RS07765	COG1766	The M ring may be actively involved in energy transduction
GH266_RS07775	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GH266_RS07785	COG0482	sulfurtransferase activity
GH266_RS07800	COG2226	methyltransferase
GH266_RS07850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GH266_RS07855	COG1321	iron dependent repressor
GH266_RS07855	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GH266_RS07860	COG1121	(ABC) transporter
GH266_RS07865	COG0803	Belongs to the bacterial solute-binding protein 9 family
GH266_RS07870	COG1349	DNA-binding transcription factor activity
GH266_RS07875	COG3842	ATPase activity
GH266_RS07890	COG0395	ABC-type sugar transport system, permease component
GH266_RS07895	COG2304	oxidoreductase activity
GH266_RS07910	COG2258	MOSC domain
GH266_RS07920	COG0444	Belongs to the ABC transporter superfamily
GH266_RS07925	COG4608	Belongs to the ABC transporter superfamily
GH266_RS07930	COG0747	negative chemotaxis
GH266_RS07935	COG0601	transmembrane transport
GH266_RS07945	COG0405	Gamma-glutamyltransferase
GH266_RS07965	COG4177	L-phenylalanine transmembrane transporter activity
GH266_RS07970	COG0559	Belongs to the binding-protein-dependent transport system permease family
GH266_RS07985	COG1802	Transcriptional regulator
GH266_RS07995	COG0667	Aldo Keto reductase
GH266_RS08010	COG3246	L-lysine catabolic process to acetate
GH266_RS08015	COG5001	Diguanylate cyclase
GH266_RS08050	COG0784	Response regulator, receiver
GH266_RS08050	COG2205	protein histidine kinase activity
GH266_RS08050	COG2198	Histidine kinase
GH266_RS08065	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
GH266_RS08070	COG3454	Phosphonate metabolism
GH266_RS08075	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
GH266_RS08080	COG3639	organic phosphonate transmembrane transporter activity
GH266_RS08090	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
GH266_RS08095	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GH266_RS08105	COG4778	phosphonate C-P lyase system protein PhnL
GH266_RS08110	COG4107	phosphonate C-P lyase system protein PhnK
GH266_RS08115	COG3627	carbon phosphorus lyase activity
GH266_RS08120	COG3626	phosphonate metabolism
GH266_RS08125	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
GH266_RS08130	COG3624	Phosphonate C-P lyase system protein PhnG
GH266_RS08135	COG2188	Transcriptional regulator
GH266_RS08140	COG0446	pyridine nucleotide-disulphide oxidoreductase
GH266_RS08150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GH266_RS08155	COG0006	proline dipeptidase activity
GH266_RS08160	COG1522	sequence-specific DNA binding
GH266_RS08165	COG1012	belongs to the aldehyde dehydrogenase family
GH266_RS08170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GH266_RS08180	COG0367	asparagine synthase
GH266_RS08190	COG1363	Peptidase, m42
GH266_RS08195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GH266_RS08215	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GH266_RS08225	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GH266_RS08230	COG1917	Cupin 2, conserved barrel domain protein
GH266_RS08235	COG1737	Transcriptional regulator
GH266_RS08245	COG0747	negative chemotaxis
GH266_RS08260	COG0444	Belongs to the ABC transporter superfamily
GH266_RS08265	COG4608	Belongs to the ABC transporter superfamily
GH266_RS08280	COG1802	Transcriptional regulator
GH266_RS08285	COG1904	glucuronate isomerase
GH266_RS08290	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GH266_RS08310	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GH266_RS08315	COG1028	Short-chain dehydrogenase reductase Sdr
GH266_RS08320	COG0246	Mannitol dehydrogenase
GH266_RS08325	COG1312	Catalyzes the dehydration of D-mannonate
GH266_RS08330	COG2721	sulfolactate sulfo-lyase activity
GH266_RS08335	COG1278	Cold shock
GH266_RS08350	COG0431	NADPH-dependent FMN reductase
GH266_RS08365	COG1283	sodium-dependent phosphate transmembrane transporter activity
GH266_RS08375	COG0483	inositol monophosphate 1-phosphatase activity
GH266_RS08380	COG1840	ABC-type Fe3 transport system, periplasmic component
GH266_RS08405	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
GH266_RS08410	COG0583	DNA-binding transcription factor activity
GH266_RS08430	COG0559	Belongs to the binding-protein-dependent transport system permease family
GH266_RS08440	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
GH266_RS08445	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
GH266_RS08450	COG1012	belongs to the aldehyde dehydrogenase family
GH266_RS08475	COG0583	DNA-binding transcription factor activity
GH266_RS08535	COG2188	Transcriptional regulator
GH266_RS08560	COG0405	Gamma-glutamyltransferase
GH266_RS08565	COG4608	Belongs to the ABC transporter superfamily
GH266_RS08580	COG0601	transmembrane transport
GH266_RS08590	COG1414	Transcriptional regulator
GH266_RS08600	COG1850	ribulose-bisphosphate carboxylase activity
GH266_RS08610	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GH266_RS08625	COG1609	Transcriptional regulator
GH266_RS08650	COG5487	UPF0391 membrane protein
GH266_RS08680	COG0784	Response regulator, receiver
GH266_RS08700	COG4604	ABC transporter, ATP-binding protein
GH266_RS08705	COG4605	iron ion homeostasis
GH266_RS08710	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GH266_RS08715	COG4607	ABC-type enterochelin transport system periplasmic component
GH266_RS08735	COG4977	sequence-specific DNA binding
GH266_RS08740	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GH266_RS08745	COG3842	ATPase activity
GH266_RS08765	COG1609	Transcriptional regulator
GH266_RS08770	COG3842	ATPase activity
GH266_RS08775	COG1176	ABC-type spermidine putrescine transport system, permease component I
GH266_RS08780	COG1840	ABC-type Fe3 transport system, periplasmic component
GH266_RS08810	COG3842	ATPase activity
GH266_RS08825	COG3920	Histidine kinase
GH266_RS08825	COG2202	Pas domain
GH266_RS08830	COG1028	Short-chain dehydrogenase reductase Sdr
GH266_RS08835	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
GH266_RS08870	COG2032	superoxide dismutase activity
GH266_RS08910	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GH266_RS08985	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GH266_RS09035	COG0418	dihydroorotase activity
GH266_RS09055	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GH266_RS09065	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GH266_RS09080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GH266_RS09085	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GH266_RS09090	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GH266_RS09105	COG0179	Fumarylacetoacetate (FAA) hydrolase
GH266_RS09110	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GH266_RS09140	COG1671	Belongs to the UPF0178 family
GH266_RS09150	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GH266_RS09155	COG3383	formate dehydrogenase (NAD+) activity
GH266_RS09175	COG3852	Histidine kinase
GH266_RS09185	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
GH266_RS09190	COG1518	maintenance of DNA repeat elements
GH266_RS09220	COG2376	Dihydroxyacetone kinase
GH266_RS09225	COG2084	Dehydrogenase
GH266_RS09230	COG1012	belongs to the aldehyde dehydrogenase family
GH266_RS09265	COG0596	Alpha beta hydrolase
GH266_RS09320	COG0076	glutamate decarboxylase activity
GH266_RS09325	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
GH266_RS09355	COG2610	gluconate transmembrane transporter activity
GH266_RS09365	COG2015	COG2015, Alkyl sulfatase and related hydrolases
GH266_RS09380	COG1028	Short-chain dehydrogenase reductase Sdr
GH266_RS09380	COG3347	Dehydrogenase
GH266_RS09390	COG1869	D-ribose catabolic process
GH266_RS09395	COG1129	ABC transporter
GH266_RS09405	COG1172	Belongs to the binding-protein-dependent transport system permease family
GH266_RS09410	COG2390	Transcriptional regulator
GH266_RS09445	COG4176	ABC-type proline glycine betaine transport system permease component
GH266_RS09450	COG4175	Glycine betaine
GH266_RS09455	COG2113	Glycine betaine
GH266_RS09460	COG1349	DNA-binding transcription factor activity
GH266_RS09470	COG4948	Mandelate Racemase Muconate Lactonizing
GH266_RS09475	COG0154	amidase activity
GH266_RS09485	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GH266_RS09500	COG4336	lyase activity
GH266_RS09505	COG0583	DNA-binding transcription factor activity
GH266_RS09515	COG0326	Molecular chaperone. Has ATPase activity
GH266_RS09520	COG0584	glycerophosphoryl diester phosphodiesterase
GH266_RS09525	COG0673	inositol 2-dehydrogenase activity
GH266_RS09555	COG0673	inositol 2-dehydrogenase activity
GH266_RS09565	COG2376	Dihydroxyacetone kinase
GH266_RS09590	COG1461	Dihydroxyacetone kinase
GH266_RS09595	COG3842	ATPase activity
GH266_RS09610	COG0395	ABC-type sugar transport system, permease component
GH266_RS09615	COG1175	transmembrane transport
GH266_RS09625	COG1250	3-hydroxyacyl-CoA dehydrogenase
GH266_RS09625	COG1024	Enoyl-CoA hydratase
GH266_RS09630	COG3971	2-oxopent-4-enoate hydratase activity
GH266_RS09645	COG1070	Carbohydrate kinase
GH266_RS09655	COG0438	transferase activity, transferring glycosyl groups
GH266_RS09680	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GH266_RS09685	COG0575	Belongs to the CDS family
GH266_RS09690	COG4221	oxidoreductase activity
GH266_RS09695	COG1260	myo-inositol-1-phosphate synthase
GH266_RS09705	COG0156	8-amino-7-oxononanoate synthase activity
GH266_RS09715	COG0028	Belongs to the TPP enzyme family
GH266_RS09715	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
GH266_RS09730	COG0604	alcohol dehydrogenase
GH266_RS09755	COG0559	Belongs to the binding-protein-dependent transport system permease family
GH266_RS09765	COG0411	ABC transporter
GH266_RS09775	COG0410	ABC transporter
GH266_RS09780	COG1028	Short-chain dehydrogenase reductase Sdr
GH266_RS09805	COG2183	response to ionizing radiation
GH266_RS09810	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GH266_RS09820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GH266_RS09825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GH266_RS09845	COG1802	Transcriptional regulator
GH266_RS09850	COG0436	Aminotransferase
GH266_RS09855	COG0745	RESPONSE REGULATOR receiver
GH266_RS09860	COG1157	protein secretion by the type III secretion system
GH266_RS09890	COG0668	transmembrane transport
GH266_RS09895	COG0747	negative chemotaxis
GH266_RS09900	COG0601	transmembrane transport
GH266_RS09905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GH266_RS09910	COG0444	Belongs to the ABC transporter superfamily
GH266_RS09915	COG4608	Belongs to the ABC transporter superfamily
GH266_RS09940	COG0643	Histidine kinase
GH266_RS09940	COG2198	Histidine kinase
GH266_RS09955	COG2201	protein-glutamate methylesterase activity
GH266_RS09975	COG0564	pseudouridine synthase activity
GH266_RS09980	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GH266_RS10000	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GH266_RS10010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GH266_RS10025	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GH266_RS10030	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GH266_RS10035	COG0037	tRNA processing
GH266_RS10045	COG2885	chlorophyll binding
GH266_RS10050	COG0823	Involved in the tonB-independent uptake of proteins
GH266_RS10060	COG0848	biopolymer transport protein
GH266_RS10065	COG0811	peptide transport
GH266_RS10070	COG0824	Thioesterase
GH266_RS10075	COG2255	four-way junction helicase activity
GH266_RS10080	COG0632	four-way junction helicase activity
GH266_RS10085	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GH266_RS10090	COG0840	transmembrane signaling receptor activity
GH266_RS10095	COG0217	transcriptional regulatory protein
GH266_RS10100	COG1692	metallophosphoesterase
GH266_RS10140	COG0126	phosphoglycerate kinase activity
GH266_RS10145	COG3588	fructose-bisphosphate aldolase
GH266_RS10150	COG0352	thiamine-phosphate diphosphorylase activity
GH266_RS10160	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GH266_RS10165	COG0483	inositol monophosphate 1-phosphatase activity
GH266_RS10205	COG0254	rRNA binding
GH266_RS10210	COG1132	(ABC) transporter
GH266_RS10215	COG1028	Short-chain dehydrogenase reductase Sdr
GH266_RS10225	COG3550	peptidyl-serine autophosphorylation
GH266_RS10255	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GH266_RS10260	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GH266_RS10265	COG0534	Mate efflux family protein
GH266_RS10270	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GH266_RS10290	COG2204	response regulator
GH266_RS10315	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GH266_RS10320	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GH266_RS10325	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
GH266_RS10330	COG5001	Diguanylate cyclase
GH266_RS10330	COG3300	MHYT domain
GH266_RS10335	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GH266_RS10345	COG3750	Belongs to the UPF0335 family
GH266_RS10375	COG0469	pyruvate kinase activity
GH266_RS10385	COG0457	Tetratricopeptide repeat
GH266_RS10390	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GH266_RS10425	COG0071	Belongs to the small heat shock protein (HSP20) family
GH266_RS10440	COG0067	glutamate synthase
GH266_RS10440	COG0069	glutamate synthase activity
GH266_RS10440	COG0070	glutamate synthase
GH266_RS10460	COG0346	lactoylglutathione lyase activity
GH266_RS10470	COG2951	lytic endotransglycosylase activity
GH266_RS10480	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GH266_RS10480	COG0517	IMP dehydrogenase activity
GH266_RS10485	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GH266_RS10500	COG0330	HflC and HflK could
GH266_RS10505	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GH266_RS10510	COG0745	RESPONSE REGULATOR receiver
GH266_RS10540	COG0559	Belongs to the binding-protein-dependent transport system permease family
GH266_RS10550	COG1022	Amp-dependent synthetase and ligase
GH266_RS10555	COG4191	Histidine kinase
GH266_RS10555	COG0784	Response regulator, receiver
GH266_RS10580	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GH266_RS10585	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
GH266_RS10610	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
GH266_RS10640	COG0523	cobalamin synthesis protein
GH266_RS10660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GH266_RS10665	COG1609	Transcriptional regulator
GH266_RS10680	COG2249	NAD(P)H dehydrogenase (quinone) activity
GH266_RS10685	COG2249	NAD(P)H dehydrogenase (quinone) activity
GH266_RS10695	COG0402	S-adenosylhomocysteine deaminase activity
GH266_RS10700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GH266_RS10730	COG1393	Belongs to the ArsC family
GH266_RS10740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GH266_RS10745	COG4166	transmembrane transport
GH266_RS10755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GH266_RS10760	COG0444	Belongs to the ABC transporter superfamily
GH266_RS10765	COG4608	Belongs to the ABC transporter superfamily
GH266_RS10770	COG2217	Heavy metal translocating P-type atpase
GH266_RS10785	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GH266_RS10795	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GH266_RS10805	COG4191	Histidine kinase
GH266_RS10820	COG1522	sequence-specific DNA binding
GH266_RS10830	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
GH266_RS10840	COG1877	trehalose-phosphatase activity
GH266_RS10850	COG4214	carbohydrate transport
GH266_RS10855	COG4213	ABC transporter substrate-binding protein
GH266_RS10860	COG1940	carbohydrate kinase activity
GH266_RS10860	COG1846	Transcriptional regulator
GH266_RS10875	COG0183	Belongs to the thiolase family
GH266_RS10880	COG0318	PFAM AMP-dependent synthetase and ligase
GH266_RS10885	COG1268	BioY protein
GH266_RS10890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GH266_RS10895	COG1122	ATPase activity
GH266_RS10925	COG0739	heme binding
GH266_RS10930	COG0542	response to heat
GH266_RS10940	COG2890	protein-(glutamine-N5) methyltransferase activity
GH266_RS10945	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GH266_RS10955	COG0527	aspartate kinase activity
GH266_RS10960	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GH266_RS10975	COG5507	3-demethylubiquinone-9 3-methyltransferase
GH266_RS10995	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GH266_RS11005	COG1040	competence protein
GH266_RS11020	COG0494	nUDIX hydrolase
GH266_RS11030	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GH266_RS11045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GH266_RS11050	COG0653	protein targeting
GH266_RS11070	COG1376	ErfK ybiS ycfS ynhG family protein
GH266_RS11075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GH266_RS11080	COG0508	dehydrogenase complex catalyzes the overall conversion of
GH266_RS11080	COG0596	Alpha beta hydrolase
GH266_RS11085	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GH266_RS11090	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GH266_RS11095	COG0667	Aldo Keto reductase
GH266_RS11105	COG1136	(ABC) transporter
GH266_RS11120	COG0670	Belongs to the BI1 family
GH266_RS11150	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GH266_RS11170	COG1295	ribonuclease BN
GH266_RS11215	COG0235	Class ii aldolase
GH266_RS11225	COG3025	triphosphatase activity
GH266_RS11240	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GH266_RS11250	COG4266	Belongs to the allantoicase family
GH266_RS11255	COG3648	Uricase
GH266_RS11255	COG3195	allantoin biosynthetic process
GH266_RS11275	COG3713	MltA-interacting MipA family protein
GH266_RS11285	COG3339	Conserved Protein
GH266_RS11290	COG0138	bifunctional purine biosynthesis protein purh
GH266_RS11305	COG0501	Belongs to the peptidase M48B family
GH266_RS11320	COG1674	ftsk spoiiie
GH266_RS11330	COG0189	ligase activity
GH266_RS11335	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GH266_RS11340	COG4133	protoheme IX ABC transporter activity
GH266_RS11345	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GH266_RS11350	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GH266_RS11360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GH266_RS11370	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GH266_RS11390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GH266_RS11410	COG1028	Short-chain dehydrogenase reductase Sdr
GH266_RS11430	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GH266_RS11440	COG3034	peptidoglycan biosynthetic process
GH266_RS11445	COG0825	malonyl-CoA metabolic process
GH266_RS11455	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GH266_RS11465	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GH266_RS11485	COG5001	Diguanylate cyclase
GH266_RS11485	COG3447	MASE1 domain protein
GH266_RS11485	COG5002	protein histidine kinase activity
GH266_RS11495	COG2192	nodulation
GH266_RS11505	COG2124	cytochrome p450
GH266_RS11515	COG1032	radical SAM domain protein
GH266_RS11565	COG0583	DNA-binding transcription factor activity
GH266_RS11570	COG2814	Major facilitator Superfamily
GH266_RS11585	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GH266_RS11620	COG1652	LysM domain
GH266_RS11650	COG0495	leucyl-tRNA aminoacylation
GH266_RS11660	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GH266_RS11665	COG0287	Prephenate dehydrogenase
GH266_RS11665	COG1605	Chorismate mutase
GH266_RS11670	COG0228	four-way junction DNA binding
GH266_RS11675	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GH266_RS11685	COG0336	Belongs to the RNA methyltransferase TrmD family
GH266_RS11690	COG0335	large ribosomal subunit rRNA binding
GH266_RS11700	COG2884	Cell division ATP-binding protein ftsE
GH266_RS11710	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GH266_RS11710	COG0037	tRNA processing
GH266_RS11715	COG0745	RESPONSE REGULATOR receiver
GH266_RS11725	COG0019	diaminopimelate decarboxylase activity
GH266_RS11735	COG0165	Argininosuccinate lyase
GH266_RS11740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GH266_RS11750	COG1250	3-hydroxyacyl-CoA dehydrogenase
GH266_RS11755	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GH266_RS11760	COG2086	electron transfer activity
GH266_RS11780	COG0300	oxidoreductase activity
GH266_RS11785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GH266_RS11790	COG1946	Acyl-CoA thioesterase
GH266_RS11795	COG0523	cobalamin synthesis protein
GH266_RS11800	COG1686	Belongs to the peptidase S11 family
GH266_RS11805	COG0829	nickel cation binding
GH266_RS11810	COG0831	urea catabolic process
GH266_RS11815	COG0832	Belongs to the urease beta subunit family
GH266_RS11820	COG3755	Protein conserved in bacteria
GH266_RS11825	COG0804	urea catabolic process
GH266_RS11840	COG0830	nickel cation binding
GH266_RS11845	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
GH266_RS11870	COG0697	spore germination
GH266_RS11890	COG2917	probably involved in intracellular septation
GH266_RS11895	COG0552	protein localization to endoplasmic reticulum
GH266_RS11900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GH266_RS11905	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GH266_RS11910	COG1741	Belongs to the pirin family
GH266_RS11920	COG0745	RESPONSE REGULATOR receiver
GH266_RS11930	COG1764	response to oxidative stress
GH266_RS11935	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
GH266_RS11945	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GH266_RS11975	COG2814	Major facilitator Superfamily
GH266_RS11980	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GH266_RS11985	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GH266_RS11990	COG0287	Prephenate dehydrogenase
GH266_RS11995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GH266_RS12000	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GH266_RS12005	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GH266_RS12005	COG2813	Specifically methylates the guanine in position
GH266_RS12065	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GH266_RS12095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GH266_RS12115	COG0181	hydroxymethylbilane synthase activity
GH266_RS12120	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GH266_RS12130	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GH266_RS12145	COG2264	protein methyltransferase activity
GH266_RS12150	COG1473	amidohydrolase
GH266_RS12160	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GH266_RS12170	COG2835	tetraacyldisaccharide 4'-kinase activity
GH266_RS12180	COG3118	belongs to the thioredoxin family
GH266_RS12225	COG2207	Transcriptional regulator
GH266_RS12235	COG3453	Protein conserved in bacteria
GH266_RS12235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GH266_RS12325	COG0563	adenylate kinase activity
GH266_RS12435	COG0741	lytic transglycosylase activity
GH266_RS12455	COG4962	Type ii secretion system protein e
GH266_RS12470	COG3451	type IV secretory pathway VirB4
GH266_RS12485	COG3846	protein secretion by the type IV secretion system
GH266_RS12500	COG2948	multi-organism process
GH266_RS12510	COG0583	DNA-binding transcription factor activity
GH266_RS12515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GH266_RS12520	COG1999	signal sequence binding
GH266_RS12530	COG3794	PFAM blue (type 1) copper domain protein
GH266_RS12555	COG0789	Transcriptional regulator
GH266_RS12570	COG3034	peptidoglycan biosynthetic process
GH266_RS12575	COG1376	ErfK ybiS ycfS ynhG family protein
GH266_RS12575	COG1388	LysM domain
GH266_RS12585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GH266_RS12590	COG1376	ErfK ybiS ycfS ynhG family protein
GH266_RS12595	COG2072	flavoprotein involved in K transport
GH266_RS12605	COG4988	ABC transporter
GH266_RS12610	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GH266_RS12620	COG1294	oxidase, subunit
GH266_RS12650	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GH266_RS12655	COG0640	Transcriptional regulator
GH266_RS12670	COG0028	Belongs to the TPP enzyme family
GH266_RS12680	COG1230	cation diffusion facilitator family transporter
GH266_RS12685	COG0640	Transcriptional regulator
GH266_RS12695	COG1937	Protein conserved in bacteria
GH266_RS12700	COG2814	Major facilitator Superfamily
GH266_RS12715	COG0678	peroxiredoxin activity
GH266_RS12715	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GH266_RS12720	COG1937	Protein conserved in bacteria
GH266_RS12730	COG0789	Transcriptional regulator
GH266_RS12760	COG1230	cation diffusion facilitator family transporter
GH266_RS12770	COG0785	Cytochrome C biogenesis protein
GH266_RS12775	COG1230	cation diffusion facilitator family transporter
GH266_RS12780	COG1914	H( )-stimulated, divalent metal cation uptake system
GH266_RS12785	COG1321	iron dependent repressor
GH266_RS12820	COG1733	regulation of RNA biosynthetic process
GH266_RS12845	COG3842	ATPase activity
GH266_RS12855	COG1176	ABC-type spermidine putrescine transport system, permease component I
GH266_RS12860	COG4149	molybdate abc transporter
GH266_RS12865	COG1609	Transcriptional regulator
GH266_RS12870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GH266_RS12880	COG0137	argininosuccinate synthase activity
GH266_RS12885	COG0437	4 iron, 4 sulfur cluster binding
GH266_RS12890	COG0142	geranyltranstransferase activity
GH266_RS12900	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GH266_RS12915	COG0183	Belongs to the thiolase family
GH266_RS12930	COG0405	Gamma-glutamyltransferase
GH266_RS12945	COG0004	ammonium transporteR
GH266_RS12950	COG0347	Belongs to the P(II) protein family
GH266_RS12965	COG2154	pterin-4-alpha-carbinolamine dehydratase
GH266_RS12970	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GH266_RS12980	COG3214	Protein conserved in bacteria
GH266_RS12985	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GH266_RS13010	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GH266_RS13015	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
GH266_RS13020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GH266_RS13030	COG0288	reversible hydration of carbon dioxide
GH266_RS13035	COG2030	dehydratase
GH266_RS13040	COG4974	Belongs to the 'phage' integrase family
GH266_RS13045	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GH266_RS13050	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GH266_RS13055	COG4536	flavin adenine dinucleotide binding
GH266_RS13085	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GH266_RS13090	COG0405	Gamma-glutamyltransferase
GH266_RS13120	COG2391	methyltransferase activity
GH266_RS13150	COG4783	chaperone-mediated protein folding
GH266_RS13160	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GH266_RS13170	COG0671	phosphoesterase, PA-phosphatase related
GH266_RS13190	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GH266_RS13200	COG1595	DNA-templated transcription, initiation
GH266_RS13205	COG1475	DNA binding
GH266_RS13210	COG1192	Involved in chromosome partitioning
GH266_RS13215	COG0357	Ribosomal RNA small subunit methyltransferase G
GH266_RS13220	COG0445	tRNA wobble uridine modification
GH266_RS13225	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GH266_RS13230	COG1331	Highly conserved protein containing a thioredoxin domain
GH266_RS13240	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GH266_RS13250	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GH266_RS13255	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GH266_RS13260	COG0424	maF-like protein
GH266_RS13265	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GH266_RS13270	COG0237	dephospho-CoA kinase activity
GH266_RS13290	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GH266_RS13295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GH266_RS13300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GH266_RS13310	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GH266_RS13330	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GH266_RS13335	COG0280	phosphate acetyltransferase
GH266_RS13335	COG0281	malic enzyme
GH266_RS13340	COG0135	phosphoribosylanthranilate isomerase activity
GH266_RS13345	COG0133	tryptophan synthase activity
GH266_RS13350	COG1396	sequence-specific DNA binding
GH266_RS13355	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GH266_RS13370	COG0251	oxidation-reduction process
GH266_RS13405	COG0864	Transcriptional regulator
GH266_RS13410	COG0747	negative chemotaxis
GH266_RS13415	COG0601	transmembrane transport
GH266_RS13420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GH266_RS13485	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
GH266_RS13495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GH266_RS13495	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GH266_RS13515	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GH266_RS13525	COG1396	sequence-specific DNA binding
GH266_RS13530	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GH266_RS13535	COG0728	peptidoglycan biosynthetic process
GH266_RS13565	COG3485	protocatechuate 3,4-dioxygenase
GH266_RS13570	COG3485	protocatechuate 3,4-dioxygenase
GH266_RS13575	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GH266_RS13585	COG0583	DNA-binding transcription factor activity
GH266_RS13615	COG0174	glutamine synthetase
GH266_RS13635	COG1454	alcohol dehydrogenase
GH266_RS13645	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GH266_RS13650	COG0285	dihydrofolate synthase activity
GH266_RS13655	COG1072	(Pantothenic acid kinase))
GH266_RS13660	COG0140	phosphoribosyl-ATP diphosphatase activity
GH266_RS13665	COG0107	imidazoleglycerol-phosphate synthase activity
GH266_RS13670	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GH266_RS13675	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GH266_RS13685	COG0131	Imidazoleglycerol-phosphate dehydratase
GH266_RS13690	COG0284	orotidine-5'-phosphate decarboxylase activity
GH266_RS13695	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GH266_RS13705	COG1960	acyl-CoA dehydrogenase activity
GH266_RS13710	COG0583	DNA-binding transcription factor activity
GH266_RS13715	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GH266_RS13720	COG5001	Diguanylate cyclase
GH266_RS13720	COG5002	protein histidine kinase activity
GH266_RS13755	COG0640	Transcriptional regulator
GH266_RS13760	COG0671	phosphoesterase, PA-phosphatase related
GH266_RS13780	COG2326	polyphosphate kinase activity
GH266_RS13785	COG0402	S-adenosylhomocysteine deaminase activity
GH266_RS13805	COG3083	sulfuric ester hydrolase activity
GH266_RS13810	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GH266_RS13820	COG3743	rRNA binding
GH266_RS13820	COG0052	Belongs to the universal ribosomal protein uS2 family
GH266_RS13825	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GH266_RS13830	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GH266_RS13835	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GH266_RS13855	COG2814	Major facilitator Superfamily
GH266_RS13860	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GH266_RS13885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GH266_RS13900	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GH266_RS13905	COG0756	dUTP diphosphatase activity
GH266_RS13910	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GH266_RS13920	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GH266_RS13925	COG0792	nuclease activity
GH266_RS13930	COG0189	ligase activity
GH266_RS13940	COG0625	glutathione transferase activity
GH266_RS13945	COG0493	'glutamate synthase
GH266_RS13965	COG1309	transcriptional regulator
GH266_RS13970	COG1309	transcriptional regulator
GH266_RS14005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GH266_RS14010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GH266_RS14035	COG3842	ATPase activity
GH266_RS14040	COG3842	ATPase activity
GH266_RS14045	COG1175	transmembrane transport
GH266_RS14050	COG0395	ABC-type sugar transport system, permease component
GH266_RS14065	COG0156	8-amino-7-oxononanoate synthase activity
GH266_RS14070	COG0180	Tryptophanyl-tRNA synthetase
GH266_RS14080	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
GH266_RS14090	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GH266_RS14155	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
GH266_RS14160	COG0505	Belongs to the CarA family
GH266_RS14170	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GH266_RS14175	COG1268	BioY protein
GH266_RS14185	COG1609	Transcriptional regulator
GH266_RS14190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GH266_RS14210	COG0601	transmembrane transport
GH266_RS14215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GH266_RS14220	COG0444	Belongs to the ABC transporter superfamily
GH266_RS14265	COG2186	Transcriptional regulator
GH266_RS14295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GH266_RS14305	COG1446	asparaginase
GH266_RS14315	COG0747	negative chemotaxis
GH266_RS14320	COG0601	transmembrane transport
GH266_RS14330	COG4172	Belongs to the ABC transporter superfamily
GH266_RS14355	COG0583	DNA-binding transcription factor activity
GH266_RS14360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GH266_RS14365	COG0730	response to heat
GH266_RS14390	COG1960	acyl-CoA dehydrogenase activity
GH266_RS14395	COG1028	Short-chain dehydrogenase reductase Sdr
GH266_RS14405	COG0318	PFAM AMP-dependent synthetase and ligase
GH266_RS14420	COG1115	amino acid carrier protein
GH266_RS14425	COG0252	asparaginase activity
GH266_RS14440	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GH266_RS14455	COG1414	Transcriptional regulator
GH266_RS14480	COG1012	belongs to the aldehyde dehydrogenase family
GH266_RS14495	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GH266_RS14505	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GH266_RS14510	COG1609	Transcriptional regulator
GH266_RS14520	COG0024	Methionine aminopeptidase
GH266_RS14530	COG0277	FAD linked oxidase domain protein
GH266_RS14535	COG1070	Carbohydrate kinase
GH266_RS14545	COG1653	transport
GH266_RS14550	COG1175	transmembrane transport
GH266_RS14565	COG1028	Short-chain dehydrogenase reductase Sdr
GH266_RS14595	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GH266_RS14620	COG0765	amino acid transport
GH266_RS14625	COG0765	amino acid transport
GH266_RS14630	COG1126	abc transporter atp-binding protein
GH266_RS14640	COG0251	oxidation-reduction process
GH266_RS14645	COG3608	succinylglutamate desuccinylase aspartoacylase
GH266_RS14660	COG1850	ribulose-bisphosphate carboxylase activity
GH266_RS14665	COG0287	Prephenate dehydrogenase
GH266_RS14675	COG0473	3-isopropylmalate dehydrogenase activity
GH266_RS14680	COG1012	belongs to the aldehyde dehydrogenase family
GH266_RS14685	COG2186	Transcriptional regulator
GH266_RS14690	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GH266_RS14710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GH266_RS14715	COG2084	Dehydrogenase
GH266_RS14720	COG3395	kinase activity
GH266_RS14725	COG0235	Class ii aldolase
GH266_RS14730	COG3622	Belongs to the hyi family
GH266_RS14745	COG0395	ABC-type sugar transport system, permease component
GH266_RS14750	COG1176	ABC-type spermidine putrescine transport system, permease component I
GH266_RS14760	COG3842	ATPase activity
GH266_RS14770	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GH266_RS14805	COG1595	DNA-templated transcription, initiation
GH266_RS14810	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GH266_RS14825	COG0154	amidase activity
GH266_RS14830	COG0596	Alpha beta hydrolase
GH266_RS14855	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
GH266_RS14875	COG3135	benzoate transporter
GH266_RS14895	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GH266_RS14925	COG0318	PFAM AMP-dependent synthetase and ligase
GH266_RS14930	COG1063	alcohol dehydrogenase
GH266_RS14945	COG0559	Belongs to the binding-protein-dependent transport system permease family
GH266_RS14950	COG0683	leucine binding
GH266_RS14960	COG1137	ATPase activity
GH266_RS14990	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GH266_RS14995	COG0501	Belongs to the peptidase M48B family
GH266_RS15010	COG5285	phytanoyl-CoA dioxygenase
GH266_RS15025	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
GH266_RS15030	COG3639	organic phosphonate transmembrane transporter activity
GH266_RS15035	COG3639	organic phosphonate transmembrane transporter activity
GH266_RS15045	COG1280	lysine exporter protein (LysE YggA)
GH266_RS15050	COG0659	secondary active sulfate transmembrane transporter activity
GH266_RS15055	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GH266_RS15060	COG0484	heat shock protein binding
GH266_RS15070	COG0443	Heat shock 70 kDa protein
GH266_RS15075	COG0659	secondary active sulfate transmembrane transporter activity
GH266_RS15080	COG0589	response to stress
GH266_RS15085	COG0259	pyridoxamine-phosphate oxidase activity
GH266_RS15100	COG0725	ABC transporter, periplasmic molybdate-binding protein
GH266_RS15105	COG4149	molybdate abc transporter
GH266_RS15110	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
GH266_RS15140	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GH266_RS15150	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GH266_RS15160	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GH266_RS15165	COG1214	PFAM Peptidase M22, glycoprotease
GH266_RS15185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GH266_RS15190	COG1702	phosphate starvation-inducible protein PhoH
GH266_RS15195	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GH266_RS15200	COG1253	flavin adenine dinucleotide binding
GH266_RS15205	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GH266_RS15210	COG1396	sequence-specific DNA binding
GH266_RS15215	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GH266_RS15220	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GH266_RS15225	COG0779	Required for maturation of 30S ribosomal subunits
GH266_RS15240	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GH266_RS15240	COG3064	Membrane
GH266_RS15245	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GH266_RS15250	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GH266_RS15255	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GH266_RS15275	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GH266_RS15280	COG0588	phosphoglycerate mutase activity
GH266_RS15285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GH266_RS15290	COG0077	Prephenate dehydratase
GH266_RS15290	COG1605	Chorismate mutase
GH266_RS15295	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GH266_RS15300	COG3474	cytochrome
GH266_RS15310	COG4166	transmembrane transport
GH266_RS15315	COG4166	transmembrane transport
GH266_RS15320	COG4174	ABC transporter (Permease)
GH266_RS15325	COG4239	(ABC) transporter, permease
GH266_RS15330	COG4172	Belongs to the ABC transporter superfamily
GH266_RS15345	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GH266_RS15355	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GH266_RS15365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GH266_RS15375	COG2816	NAD+ diphosphatase activity
GH266_RS15390	COG2009	succinate dehydrogenase
GH266_RS15445	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
GH266_RS15455	COG0045	succinate-CoA ligase (ADP-forming) activity
GH266_RS15460	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GH266_RS15465	COG0567	Dehydrogenase, E1 component
GH266_RS15470	COG0508	dehydrogenase complex catalyzes the overall conversion of
GH266_RS15480	COG1280	lysine exporter protein (LysE YggA)
GH266_RS15485	COG1028	Short-chain dehydrogenase reductase Sdr
GH266_RS15505	COG4974	Belongs to the 'phage' integrase family
GH266_RS15510	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GH266_RS15520	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GH266_RS15530	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GH266_RS15535	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GH266_RS15540	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GH266_RS15545	COG3145	DNA-N1-methyladenine dioxygenase activity
GH266_RS15550	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GH266_RS15555	COG2226	methyltransferase
GH266_RS15560	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GH266_RS15565	COG1024	Enoyl-CoA hydratase
GH266_RS15570	COG0268	Binds directly to 16S ribosomal RNA
GH266_RS15575	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GH266_RS15580	COG0592	DNA-directed DNA polymerase activity
GH266_RS15585	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GH266_RS15595	COG0187	DNA topoisomerase II activity
GH266_RS15600	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GH266_RS15605	COG3046	protein related to deoxyribodipyrimidine photolyase
GH266_RS15630	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GH266_RS15630	COG3608	succinylglutamate desuccinylase aspartoacylase
GH266_RS15640	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GH266_RS15645	COG0534	Mate efflux family protein
GH266_RS15650	COG0745	RESPONSE REGULATOR receiver
GH266_RS15655	COG2205	protein histidine kinase activity
GH266_RS15660	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GH266_RS15665	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GH266_RS15665	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GH266_RS15670	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GH266_RS15685	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GH266_RS15690	COG2205	protein histidine kinase activity
GH266_RS15695	COG0802	atpase or kinase
GH266_RS15700	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GH266_RS15710	COG1074	ATP-dependent DNA helicase activity
GH266_RS15720	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GH266_RS15725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GH266_RS15735	COG2860	membrane
GH266_RS15745	COG0776	regulation of translation
GH266_RS15750	COG0616	signal peptide processing
GH266_RS15755	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GH266_RS15765	COG0539	negative regulation of cytoplasmic translation
GH266_RS15775	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GH266_RS15800	COG1780	Probably involved in ribonucleotide reductase function
GH266_RS15805	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GH266_RS15815	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GH266_RS15820	COG1028	Short-chain dehydrogenase reductase Sdr
GH266_RS15830	COG0559	Belongs to the binding-protein-dependent transport system permease family
GH266_RS15850	COG0583	DNA-binding transcription factor activity
GH266_RS15855	COG0022	dehydrogenase e1 component
GH266_RS15860	COG0508	dehydrogenase complex catalyzes the overall conversion of
GH266_RS15865	COG1028	Short-chain dehydrogenase reductase Sdr
GH266_RS15875	COG0840	transmembrane signaling receptor activity
GH266_RS15885	COG0071	Belongs to the small heat shock protein (HSP20) family
GH266_RS15895	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GH266_RS15900	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GH266_RS15905	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GH266_RS15910	COG1137	ATPase activity
GH266_RS15925	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
GH266_RS15950	COG1968	undecaprenyl-diphosphatase activity
GH266_RS15960	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GH266_RS15965	COG1028	Short-chain dehydrogenase reductase Sdr
GH266_RS15970	COG0494	nUDIX hydrolase
GH266_RS15980	COG0793	Belongs to the peptidase S41A family
GH266_RS15990	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GH266_RS15995	COG0799	negative regulation of ribosome biogenesis
GH266_RS16000	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GH266_RS16005	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GH266_RS16010	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GH266_RS16015	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GH266_RS16035	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GH266_RS16040	COG3743	rRNA binding
GH266_RS16040	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GH266_RS16050	COG0583	DNA-binding transcription factor activity
GH266_RS16080	COG1335	isochorismatase
GH266_RS16085	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GH266_RS16095	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GH266_RS16125	COG3300	MHYT domain
GH266_RS16125	COG5001	Diguanylate cyclase
GH266_RS16130	COG1902	pentaerythritol trinitrate reductase activity
GH266_RS16140	COG0640	Transcriptional regulator
GH266_RS16145	COG0701	Predicted permease
GH266_RS16160	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GH266_RS16165	COG1960	acyl-CoA dehydrogenase activity
GH266_RS16175	COG1280	lysine exporter protein (LysE YggA)
GH266_RS16180	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GH266_RS16185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GH266_RS16195	COG5001	Diguanylate cyclase
GH266_RS16195	COG3300	MHYT domain
GH266_RS16245	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
GH266_RS16250	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GH266_RS16260	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GH266_RS16265	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GH266_RS16275	COG2986	histidine ammonia-lyase
GH266_RS16280	COG1228	amidohydrolase
GH266_RS16295	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GH266_RS16310	COG3300	MHYT domain
GH266_RS16310	COG5001	Diguanylate cyclase
GH266_RS16375	COG2875	Belongs to the precorrin methyltransferase family
GH266_RS16385	COG1797	cobyrinic acid a,c-diamide synthase activity
GH266_RS16410	COG0489	protein tyrosine kinase activity
GH266_RS16410	COG3206	protein involved in exopolysaccharide biosynthesis
GH266_RS16440	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GH266_RS16460	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GH266_RS16470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GH266_RS16475	COG0183	Belongs to the thiolase family
GH266_RS16490	COG0438	transferase activity, transferring glycosyl groups
GH266_RS16505	COG2943	transferase activity, transferring hexosyl groups
GH266_RS16530	COG1476	TRANSCRIPTIONal
GH266_RS16535	COG2391	methyltransferase activity
GH266_RS16560	COG1294	oxidase, subunit
GH266_RS16565	COG1271	oxidase subunit
GH266_RS16570	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GH266_RS16585	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GH266_RS16590	COG2329	Antibiotic biosynthesis monooxygenase
GH266_RS16605	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GH266_RS16625	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GH266_RS16635	COG0471	metal ion transport
GH266_RS16635	COG3273	potassium ion transport
GH266_RS16655	COG0745	RESPONSE REGULATOR receiver
GH266_RS16660	COG2205	protein histidine kinase activity
GH266_RS16685	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GH266_RS16690	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GH266_RS16695	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GH266_RS16700	COG0840	transmembrane signaling receptor activity
GH266_RS16705	COG0438	transferase activity, transferring glycosyl groups
GH266_RS16720	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
GH266_RS16725	COG0481	GTPase activity
GH266_RS16730	COG1032	radical SAM domain protein
GH266_RS16745	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GH266_RS16750	COG1214	PFAM Peptidase M22, glycoprotease
GH266_RS16750	COG0456	acetyltransferase
GH266_RS16775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GH266_RS16780	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GH266_RS16810	COG0840	transmembrane signaling receptor activity
GH266_RS16810	COG3290	protein histidine kinase activity
GH266_RS16825	COG4136	ATPase activity
GH266_RS16830	COG4135	transport system, permease component
GH266_RS16835	COG4134	Bacterial extracellular solute-binding protein
GH266_RS16840	COG1522	sequence-specific DNA binding
GH266_RS16850	COG1643	Atp-dependent helicase
GH266_RS16855	COG0837	glucose binding
GH266_RS16860	COG1803	Methylglyoxal synthase
GH266_RS16900	COG0295	cytidine deaminase activity
GH266_RS16910	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GH266_RS16915	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GH266_RS16920	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GH266_RS16930	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
GH266_RS16935	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GH266_RS16945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GH266_RS16985	COG4964	Belongs to the GSP D family
GH266_RS17005	COG4964	Belongs to the GSP D family
GH266_RS17040	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GH266_RS17075	COG0242	peptide deformylase activity
GH266_RS17080	COG2095	MarC family integral membrane protein
GH266_RS17085	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GH266_RS17095	COG0101	tRNA pseudouridine synthase activity
GH266_RS17105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GH266_RS17120	COG2171	N-acyltransferase activity
GH266_RS17130	COG2824	Alkylphosphonate utilization operon protein PhnA
GH266_RS17140	COG1902	pentaerythritol trinitrate reductase activity
GH266_RS17145	COG0583	DNA-binding transcription factor activity
GH266_RS17150	COG3739	integral membrane protein
GH266_RS17160	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
GH266_RS17165	COG5001	Diguanylate cyclase
GH266_RS17165	COG3706	GGDEF domain
GH266_RS17165	COG4251	negative regulation of phosphorylation
GH266_RS17165	COG2203	Gaf domain
GH266_RS17170	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GH266_RS17175	COG0110	maltose O-acetyltransferase activity
GH266_RS17180	COG0706	membrane insertase activity
GH266_RS17185	COG0594	ribonuclease P activity
GH266_RS17190	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GH266_RS17210	COG2205	protein histidine kinase activity
GH266_RS17230	COG5000	phosphorelay sensor kinase activity
GH266_RS17230	COG5002	protein histidine kinase activity
GH266_RS17235	COG0745	RESPONSE REGULATOR receiver
GH266_RS17240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GH266_RS17245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GH266_RS17255	COG0492	ferredoxin-NADP+ reductase activity
GH266_RS17260	COG1959	2 iron, 2 sulfur cluster binding
GH266_RS17265	COG3443	Belongs to the bacterial solute-binding protein 9 family
GH266_RS17290	COG0583	DNA-binding transcription factor activity
GH266_RS17295	COG2814	Major facilitator Superfamily
GH266_RS17300	COG1802	Transcriptional regulator
GH266_RS17315	COG0444	Belongs to the ABC transporter superfamily
GH266_RS17325	COG0601	transmembrane transport
GH266_RS17330	COG0747	negative chemotaxis
GH266_RS17335	COG0179	Fumarylacetoacetate (FAA) hydrolase
GH266_RS17340	COG0179	Fumarylacetoacetate (FAA) hydrolase
GH266_RS17350	COG1053	succinate dehydrogenase
GH266_RS17355	COG1028	Short-chain dehydrogenase reductase Sdr
GH266_RS17380	COG1028	Short-chain dehydrogenase reductase Sdr
GH266_RS17415	COG2124	cytochrome p450
GH266_RS17440	COG0235	Class ii aldolase
GH266_RS17455	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
GH266_RS17460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GH266_RS17465	COG0351	phosphomethylpyrimidine kinase
GH266_RS17480	COG2022	thiamine diphosphate biosynthetic process
GH266_RS17490	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GH266_RS17495	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GH266_RS17500	COG1116	anion transmembrane transporter activity
GH266_RS17505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GH266_RS17520	COG1760	l-serine dehydratase
GH266_RS17535	COG3483	tryptophan 2,3-dioxygenase activity
GH266_RS17555	COG0559	Belongs to the binding-protein-dependent transport system permease family
GH266_RS17565	COG0683	leucine binding
GH266_RS17570	COG1959	2 iron, 2 sulfur cluster binding
GH266_RS17580	COG1309	transcriptional regulator
GH266_RS17605	COG1278	Cold shock
GH266_RS17625	COG0410	ABC transporter
GH266_RS17645	COG2081	HI0933 family
GH266_RS17655	COG0463	Glycosyl transferase, family 2
GH266_RS17680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GH266_RS17680	COG1648	precorrin-2 dehydrogenase activity
GH266_RS17690	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GH266_RS17695	COG0175	sulfate reduction
GH266_RS17715	COG2130	NADP-dependent
GH266_RS17720	COG2951	lytic endotransglycosylase activity
GH266_RS17725	COG0745	RESPONSE REGULATOR receiver
GH266_RS17725	COG3706	GGDEF domain
GH266_RS17735	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GH266_RS17745	COG1177	transmembrane transport
GH266_RS17750	COG1176	ABC-type spermidine putrescine transport system, permease component I
GH266_RS17755	COG3842	ATPase activity
GH266_RS17765	COG0174	glutamine synthetase
GH266_RS17775	COG0174	glutamine synthetase
GH266_RS17785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GH266_RS17790	COG4149	molybdate abc transporter
GH266_RS17795	COG1840	ABC-type Fe3 transport system, periplasmic component
GH266_RS17805	COG2205	protein histidine kinase activity
GH266_RS17845	COG0028	Belongs to the TPP enzyme family
GH266_RS17860	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
GH266_RS17870	COG4191	Histidine kinase
GH266_RS17890	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GH266_RS17890	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GH266_RS17895	COG1570	exodeoxyribonuclease VII activity
GH266_RS17915	COG5002	protein histidine kinase activity
GH266_RS17915	COG5000	phosphorelay sensor kinase activity
GH266_RS17935	COG0583	DNA-binding transcription factor activity
GH266_RS17965	COG1139	Iron-sulfur cluster binding protein
GH266_RS17970	COG0247	lactate metabolic process
GH266_RS17975	COG2186	Transcriptional regulator
GH266_RS17980	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GH266_RS18005	COG0583	DNA-binding transcription factor activity
GH266_RS18010	COG0277	FAD linked oxidase domain protein
GH266_RS18015	COG0277	FAD linked oxidase domain protein
GH266_RS18020	COG0247	lactate metabolic process
GH266_RS18025	COG1376	ErfK ybiS ycfS ynhG family protein
GH266_RS18040	COG2818	Glycosylase
GH266_RS18050	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
GH266_RS18065	COG0154	amidase activity
GH266_RS18085	COG0463	Glycosyl transferase, family 2
GH266_RS18090	COG0124	histidyl-tRNA synthetase
GH266_RS18100	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GH266_RS18105	COG2900	Belongs to the SlyX family
GH266_RS18110	COG0459	protein refolding
GH266_RS18115	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GH266_RS18130	COG2204	response regulator
GH266_RS18135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GH266_RS18145	COG1136	(ABC) transporter
GH266_RS18160	COG0612	Peptidase, M16
GH266_RS18165	COG0612	Peptidase, M16
GH266_RS18175	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GH266_RS18185	COG0196	riboflavin kinase activity
GH266_RS18190	COG2030	dehydratase
GH266_RS18195	COG0745	RESPONSE REGULATOR receiver
GH266_RS18235	COG0742	ribosomal rna small subunit methyltransferase
GH266_RS18240	COG1187	pseudouridine synthase activity
GH266_RS18245	COG0590	tRNA wobble adenosine to inosine editing
GH266_RS18260	COG1752	Esterase of the alpha-beta hydrolase superfamily
GH266_RS18280	COG1663	tetraacyldisaccharide 4'-kinase activity
GH266_RS18285	COG1519	Transferase
GH266_RS18305	COG0312	modulator of DNA gyrase
GH266_RS18320	COG0151	Belongs to the GarS family
GH266_RS18325	COG0596	Alpha beta hydrolase
GH266_RS18330	COG0312	modulator of DNA gyrase
GH266_RS18340	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GH266_RS18345	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GH266_RS18350	COG0109	protoheme IX farnesyltransferase activity
GH266_RS18375	COG3346	SURF1 family
GH266_RS18380	COG0678	peroxiredoxin activity
GH266_RS18380	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GH266_RS18390	COG1678	Uncharacterized ACR, COG1678
GH266_RS18400	COG0612	Peptidase, M16
GH266_RS18410	COG5001	Diguanylate cyclase
GH266_RS18415	COG0328	RNA-DNA hybrid ribonuclease activity
GH266_RS18420	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GH266_RS18425	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GH266_RS18435	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GH266_RS18440	COG0509	glycine decarboxylation via glycine cleavage system
GH266_RS18450	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GH266_RS18455	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GH266_RS18465	COG2189	Belongs to the N(4) N(6)-methyltransferase family
GH266_RS18470	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GH266_RS18475	COG3128	pkhd-type hydroxylase
GH266_RS18480	COG1194	a g-specific adenine glycosylase
GH266_RS18490	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GH266_RS18495	COG1196	nuclear chromosome segregation
GH266_RS18505	COG0356	it plays a direct role in the translocation of protons across the membrane
GH266_RS18510	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GH266_RS18515	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GH266_RS18525	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GH266_RS18540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GH266_RS18545	COG0521	Mo-molybdopterin cofactor biosynthetic process
GH266_RS18555	COG0281	malic enzyme
GH266_RS18555	COG0280	phosphate acetyltransferase
GH266_RS18570	COG1573	uracil-dna glycosylase
GH266_RS18590	COG0752	glycyl-tRNA synthetase alpha subunit
GH266_RS18600	COG1704	LemA family
GH266_RS18635	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GH266_RS18640	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GH266_RS18650	COG2203	Gaf domain
GH266_RS18650	COG2200	EAL domain
GH266_RS18650	COG2199	diguanylate cyclase activity
GH266_RS18655	COG3409	Peptidoglycan-binding domain 1 protein
GH266_RS18655	COG3773	Cell wall hydrolase
GH266_RS18660	COG0564	pseudouridine synthase activity
GH266_RS18680	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
GH266_RS18685	COG0354	folic acid binding
GH266_RS18690	COG0121	glutamine amidotransferase
GH266_RS18735	COG2135	peptidase activity
GH266_RS18740	COG0277	FAD linked oxidase domain protein
GH266_RS18745	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GH266_RS18750	COG0406	alpha-ribazole phosphatase activity
GH266_RS18765	COG1846	Transcriptional regulator
GH266_RS18775	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GH266_RS18780	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GH266_RS18780	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GH266_RS18785	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GH266_RS18805	COG1999	signal sequence binding
GH266_RS18810	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GH266_RS18825	COG1722	exodeoxyribonuclease VII activity
GH266_RS18830	COG0123	including yeast histone deacetylase and acetoin utilization protein
GH266_RS18835	COG0009	L-threonylcarbamoyladenylate synthase
GH266_RS18840	COG1960	acyl-CoA dehydrogenase activity
GH266_RS18845	COG1024	Enoyl-CoA hydratase
GH266_RS18850	COG0484	heat shock protein binding
GH266_RS18865	COG0598	Magnesium transport protein CorA
GH266_RS18880	COG0318	PFAM AMP-dependent synthetase and ligase
GH266_RS18885	COG0546	phosphoglycolate phosphatase activity
GH266_RS18890	COG0546	phosphoglycolate phosphatase activity
GH266_RS18895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GH266_RS18905	COG3842	ATPase activity
GH266_RS18910	COG1176	ABC-type spermidine putrescine transport system, permease component I
GH266_RS18915	COG1177	transmembrane transport
GH266_RS18935	COG5002	protein histidine kinase activity
GH266_RS18945	COG0573	inorganic phosphate transmembrane transporter activity
GH266_RS18955	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GH266_RS18960	COG0704	Plays a role in the regulation of phosphate uptake
GH266_RS18965	COG0745	RESPONSE REGULATOR receiver
GH266_RS18975	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GH266_RS18980	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GH266_RS18985	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GH266_RS19000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GH266_RS19015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GH266_RS19030	COG4717	serine-type aminopeptidase activity
GH266_RS19035	COG2081	HI0933 family
GH266_RS19040	COG2808	Putative FMN-binding domain
GH266_RS19065	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
GH266_RS19075	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
GH266_RS19080	COG0717	Belongs to the dCTP deaminase family
GH266_RS19105	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GH266_RS19110	COG2967	ApaG domain
GH266_RS19125	COG5002	protein histidine kinase activity
GH266_RS19125	COG5001	Diguanylate cyclase
GH266_RS19140	COG0840	transmembrane signaling receptor activity
GH266_RS19145	COG0840	transmembrane signaling receptor activity
GH266_RS19165	COG0167	dihydroorotate dehydrogenase activity
GH266_RS19170	COG1012	belongs to the aldehyde dehydrogenase family
GH266_RS19175	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GH266_RS19180	COG1309	transcriptional regulator
GH266_RS19195	COG4175	Glycine betaine
GH266_RS19200	COG0534	Mate efflux family protein
GH266_RS19235	COG0123	including yeast histone deacetylase and acetoin utilization protein
GH266_RS19250	COG1250	3-hydroxyacyl-CoA dehydrogenase
GH266_RS19250	COG1024	Enoyl-CoA hydratase
GH266_RS19255	COG5001	Diguanylate cyclase
GH266_RS19255	COG3300	MHYT domain
GH266_RS19260	COG0183	Belongs to the thiolase family
GH266_RS19270	COG1960	acyl-CoA dehydrogenase activity
GH266_RS19285	COG0730	response to heat
GH266_RS19305	COG1201	RNA secondary structure unwinding
GH266_RS19320	COG1793	dna ligase
GH266_RS19320	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
GH266_RS19345	COG0432	Pfam Uncharacterised protein family UPF0047
GH266_RS19355	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GH266_RS19375	COG3850	Histidine kinase
GH266_RS19375	COG5002	protein histidine kinase activity
GH266_RS19380	COG1970	mechanosensitive ion channel activity
GH266_RS19390	COG4191	Histidine kinase
GH266_RS19395	COG4566	intracellular signal transduction
GH266_RS19400	COG0745	RESPONSE REGULATOR receiver
GH266_RS19405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GH266_RS19410	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GH266_RS19425	COG3278	Belongs to the heme-copper respiratory oxidase family
GH266_RS19440	COG2010	Cytochrome c
GH266_RS19470	COG2217	Heavy metal translocating P-type atpase
GH266_RS19535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GH266_RS19540	COG0842	Transport permease protein
GH266_RS19540	COG1129	ABC transporter
GH266_RS19545	COG0842	Transport permease protein
GH266_RS19550	COG0583	DNA-binding transcription factor activity
GH266_RS19555	COG2084	Dehydrogenase
GH266_RS19560	COG1024	Enoyl-CoA hydratase
GH266_RS19565	COG0583	DNA-binding transcription factor activity
GH266_RS19580	COG1802	Transcriptional regulator
GH266_RS19600	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GH266_RS19610	COG0559	Belongs to the binding-protein-dependent transport system permease family
GH266_RS19625	COG0410	ABC transporter
GH266_RS19635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GH266_RS19650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GH266_RS19665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GH266_RS19670	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GH266_RS19705	COG0601	transmembrane transport
GH266_RS19710	COG0747	negative chemotaxis
GH266_RS19725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GH266_RS19745	COG1175	transmembrane transport
GH266_RS19750	COG3842	ATPase activity
GH266_RS19760	COG1349	DNA-binding transcription factor activity
GH266_RS19765	COG3002	Belongs to the UPF0753 family
GH266_RS19770	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GH266_RS19780	COG1522	sequence-specific DNA binding
GH266_RS19790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GH266_RS19805	COG0559	Belongs to the binding-protein-dependent transport system permease family
GH266_RS19835	COG0800	Aldolase
GH266_RS19840	COG3734	2-keto-3-deoxy-galactonokinase
GH266_RS19850	COG4948	Mandelate Racemase Muconate Lactonizing
GH266_RS19860	COG1175	transmembrane transport
GH266_RS19865	COG0395	ABC-type sugar transport system, permease component
GH266_RS19870	COG3842	ATPase activity
GH266_RS19880	COG1414	Transcriptional regulator
GH266_RS19910	COG1028	Short-chain dehydrogenase reductase Sdr
GH266_RS19915	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GH266_RS19965	COG3485	protocatechuate 3,4-dioxygenase
GH266_RS19970	COG1028	Short-chain dehydrogenase reductase Sdr
GH266_RS19990	COG3300	MHYT domain
GH266_RS19990	COG5001	Diguanylate cyclase
GH266_RS20005	COG5328	Belongs to the UPF0262 family
GH266_RS20015	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GH266_RS20020	COG0424	maF-like protein
GH266_RS20030	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GH266_RS20040	COG0737	Belongs to the 5'-nucleotidase family
GH266_RS20135	COG0583	DNA-binding transcription factor activity
GH266_RS20140	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GH266_RS20150	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GH266_RS20195	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GH266_RS20200	COG0583	DNA-binding transcription factor activity
GH266_RS20205	COG0402	S-adenosylhomocysteine deaminase activity
GH266_RS20215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GH266_RS20220	COG0765	amino acid transport
GH266_RS20225	COG0765	amino acid transport
GH266_RS20230	COG1126	abc transporter atp-binding protein
GH266_RS20235	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GH266_RS20240	COG2423	ornithine cyclodeaminase activity
GH266_RS20250	COG2186	Transcriptional regulator
GH266_RS20260	COG0667	Aldo Keto reductase
GH266_RS20270	COG3842	ATPase activity
GH266_RS20280	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GH266_RS20285	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
GH266_RS20290	COG0321	lipoyl(octanoyl) transferase activity
GH266_RS20290	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GH266_RS20305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
GH266_RS20320	COG3246	L-lysine catabolic process to acetate
GH266_RS20325	COG1028	Short-chain dehydrogenase reductase Sdr
GH266_RS20350	COG5564	TIM-barrel signal transduction protein
GH266_RS20355	COG5441	Belongs to the UPF0261 family
GH266_RS20360	COG0410	ABC transporter
GH266_RS20390	COG5564	TIM-barrel signal transduction protein
GH266_RS20390	COG2204	response regulator
GH266_RS20410	COG4771	TonB-dependent receptor
GH266_RS20435	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
GH266_RS20445	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GH266_RS20455	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GH266_RS20465	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GH266_RS20470	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GH266_RS20495	COG2124	cytochrome p450
GH266_RS20500	COG3425	synthase
GH266_RS20510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GH266_RS20515	COG1024	Enoyl-CoA hydratase
GH266_RS20520	COG0367	asparagine synthase
GH266_RS20525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GH266_RS20535	COG4615	Cyclic peptide transporter
GH266_RS20545	COG4221	oxidoreductase activity
GH266_RS20545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GH266_RS20545	COG0300	oxidoreductase activity
GH266_RS20545	COG3321	synthase
GH266_RS20550	COG2072	flavoprotein involved in K transport
GH266_RS20555	COG4221	oxidoreductase activity
GH266_RS20555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GH266_RS20555	COG4221	oxidoreductase activity
GH266_RS20555	COG3321	synthase
GH266_RS20555	COG1028	Short-chain dehydrogenase reductase Sdr
GH266_RS20555	COG3321	synthase
GH266_RS20555	COG1028	Short-chain dehydrogenase reductase Sdr
GH266_RS20555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GH266_RS20615	COG0306	phosphate transporter
GH266_RS20630	COG1959	2 iron, 2 sulfur cluster binding
GH266_RS20635	COG2346	COG2346, Truncated hemoglobins
GH266_RS20650	COG2186	Transcriptional regulator
GH266_RS20655	COG1376	ErfK ybiS ycfS ynhG family protein
GH266_RS20660	COG2186	Transcriptional regulator
GH266_RS20665	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GH266_RS20685	COG0318	PFAM AMP-dependent synthetase and ligase
GH266_RS20695	COG0840	transmembrane signaling receptor activity
GH266_RS20705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GH266_RS20710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GH266_RS20715	COG2259	Doxx family
GH266_RS20740	COG0747	negative chemotaxis
GH266_RS20745	COG0601	transmembrane transport
GH266_RS20750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GH266_RS20760	COG1473	amidohydrolase
GH266_RS20765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GH266_RS20775	COG1742	UPF0060 membrane protein
GH266_RS20855	COG0714	Associated with various cellular activities
GH266_RS20880	COG0840	transmembrane signaling receptor activity
GH266_RS20925	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
GH266_RS20940	COG0745	RESPONSE REGULATOR receiver
GH266_RS20955	COG5310	Homospermidine synthase
GH266_RS20960	COG0436	Aminotransferase
GH266_RS21000	COG0433	COG0433 Predicted ATPase
GH266_RS21010	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GH266_RS21025	COG0477	Major facilitator Superfamily
GH266_RS21030	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GH266_RS21070	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GH266_RS21080	COG0556	nucleotide-excision repair
GH266_RS21090	COG0789	Transcriptional regulator
GH266_RS21120	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GH266_RS21130	COG2111	Na H antiporter
GH266_RS21135	COG1006	Multisubunit Na H antiporter MnhC subunit
GH266_RS21150	COG2212	antiporter activity
GH266_RS21155	COG1320	monovalent cation:proton antiporter activity
GH266_RS21160	COG4957	zinc ion binding
GH266_RS21165	COG3842	ATPase activity
GH266_RS21185	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
GH266_RS21190	COG1177	transmembrane transport
GH266_RS21210	COG2205	protein histidine kinase activity
GH266_RS21220	COG2166	iron-sulfur cluster assembly
GH266_RS21250	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GH266_RS21255	COG2983	Belongs to the UPF0260 family
GH266_RS21280	COG4695	Portal protein
GH266_RS21385	COG0745	RESPONSE REGULATOR receiver
GH266_RS21390	COG5002	protein histidine kinase activity
GH266_RS21405	COG4235	cytochrome complex assembly
GH266_RS21410	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GH266_RS21415	COG1138	Cytochrome C-type biogenesis protein
GH266_RS21420	COG3088	subunit of a heme lyase
GH266_RS21435	COG0745	RESPONSE REGULATOR receiver
GH266_RS21440	COG2205	protein histidine kinase activity
GH266_RS21445	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
GH266_RS21460	COG2202	Pas domain
GH266_RS21460	COG2205	protein histidine kinase activity
GH266_RS21465	COG0308	aminopeptidase N
GH266_RS21485	COG0747	negative chemotaxis
GH266_RS21490	COG0601	transmembrane transport
GH266_RS21495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GH266_RS21530	COG1132	(ABC) transporter
GH266_RS21530	COG1132	(ABC) transporter
GH266_RS21535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GH266_RS21535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GH266_RS21540	COG1234	tRNA 3'-trailer cleavage
GH266_RS21560	COG0410	ABC transporter
GH266_RS21565	COG1137	ATPase activity
GH266_RS21575	COG0559	Belongs to the binding-protein-dependent transport system permease family
GH266_RS21590	COG2311	Membrane
GH266_RS21600	COG1028	Short-chain dehydrogenase reductase Sdr
GH266_RS21610	COG1024	Enoyl-CoA hydratase
GH266_RS21610	COG1250	3-hydroxyacyl-CoA dehydrogenase
GH266_RS21615	COG1960	acyl-CoA dehydrogenase activity
GH266_RS21625	COG0251	oxidation-reduction process
GH266_RS21640	COG1942	4-Oxalocrotonate Tautomerase
GH266_RS21660	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GH266_RS21660	COG0512	Glutamine amidotransferase of anthranilate synthase
GH266_RS21670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GH266_RS21680	COG0747	negative chemotaxis
GH266_RS21685	COG0601	transmembrane transport
GH266_RS21695	COG0444	Belongs to the ABC transporter superfamily
GH266_RS21700	COG4608	Belongs to the ABC transporter superfamily
GH266_RS21710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GH266_RS21725	COG1607	acyl-coa hydrolase
GH266_RS21730	COG0840	transmembrane signaling receptor activity
GH266_RS21735	COG2353	YceI-like domain
GH266_RS21740	COG1940	carbohydrate kinase activity
GH266_RS21750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GH266_RS21765	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GH266_RS21770	COG0747	negative chemotaxis
GH266_RS21785	COG1741	Belongs to the pirin family
GH266_RS21805	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GH266_RS21805	COG2010	Cytochrome c
GH266_RS21810	COG1454	alcohol dehydrogenase
GH266_RS21815	COG0583	DNA-binding transcription factor activity
GH266_RS21820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GH266_RS21825	COG4311	Sarcosine oxidase, delta subunit
GH266_RS21830	COG0446	pyridine nucleotide-disulphide oxidoreductase
GH266_RS21830	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GH266_RS21840	COG1177	transmembrane transport
GH266_RS21845	COG1176	ABC-type spermidine putrescine transport system, permease component I
GH266_RS21855	COG3842	ATPase activity
GH266_RS21860	COG5598	trimethylamine methyltransferase
GH266_RS21870	COG0646	methionine synthase
GH266_RS21870	COG1410	methionine synthase
GH266_RS21900	COG4166	transmembrane transport
GH266_RS21905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GH266_RS21910	COG0601	transmembrane transport
GH266_RS21925	COG0646	methionine synthase
GH266_RS21925	COG1410	methionine synthase
GH266_RS21930	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GH266_RS21950	COG5012	cobalamin binding
GH266_RS21955	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GH266_RS21965	COG2076	Multidrug Resistance protein
GH266_RS21975	COG0590	tRNA wobble adenosine to inosine editing
GH266_RS21990	COG0655	NAD(P)H dehydrogenase (quinone) activity
GH266_RS22000	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GH266_RS22005	COG1595	DNA-templated transcription, initiation
GH266_RS22025	COG2759	Belongs to the formate--tetrahydrofolate ligase family
GH266_RS22030	COG2897	thiosulfate sulfurtransferase activity
GH266_RS22035	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GH266_RS22055	COG4221	oxidoreductase activity
GH266_RS22060	COG2211	Major facilitator Superfamily
GH266_RS22065	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GH266_RS22080	COG0415	Belongs to the DNA photolyase family
GH266_RS22090	COG1120	ATPase activity
GH266_RS22095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GH266_RS22115	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GH266_RS22145	COG2514	catechol 2,3-dioxygenase activity
GH266_RS22150	COG1846	Transcriptional regulator
GH266_RS22165	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
GH266_RS22195	COG1492	cobalamin metabolic process
GH266_RS22235	COG2072	flavoprotein involved in K transport
GH266_RS22240	COG3284	Transcriptional regulator
GH266_RS22250	COG2186	Transcriptional regulator
GH266_RS22255	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GH266_RS22265	COG0729	surface antigen
GH266_RS22290	COG0156	8-amino-7-oxononanoate synthase activity
GH266_RS22305	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GH266_RS22310	COG1218	3'(2'),5'-bisphosphate nucleotidase
GH266_RS22320	COG0175	sulfate reduction
GH266_RS22330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GH266_RS22335	COG1116	anion transmembrane transporter activity
GH266_RS22340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GH266_RS22375	COG0579	oxidoreductase
GH266_RS22380	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GH266_RS22395	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GH266_RS22400	COG3754	Rhamnan synthesis protein F
GH266_RS22415	COG0175	sulfate reduction
GH266_RS22470	COG0714	Associated with various cellular activities
GH266_RS22475	COG3256	nitric oxide reductase
GH266_RS22485	COG1845	cytochrome c oxidase, subunit III
GH266_RS22495	COG0521	Mo-molybdopterin cofactor biosynthetic process
GH266_RS22515	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GH266_RS22530	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GH266_RS22535	COG2942	2-epimerase
GH266_RS22560	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GH266_RS22565	COG0673	inositol 2-dehydrogenase activity
GH266_RS22570	COG0673	inositol 2-dehydrogenase activity
GH266_RS22575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GH266_RS22580	COG0697	spore germination
GH266_RS22595	COG0183	Belongs to the thiolase family
GH266_RS22610	COG3263	regulation of cellular component size
GH266_RS22620	COG2207	Transcriptional regulator
GH266_RS22625	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GH266_RS22625	COG3433	isochorismatase activity
GH266_RS22625	COG2226	methyltransferase
GH266_RS22650	COG2814	Major facilitator Superfamily
GH266_RS22655	COG4771	TonB-dependent receptor
GH266_RS22690	COG0559	Belongs to the binding-protein-dependent transport system permease family
GH266_RS22705	COG1024	Enoyl-CoA hydratase
GH266_RS22710	COG2050	protein possibly involved in aromatic compounds catabolism
GH266_RS22740	COG1566	PFAM secretion protein HlyD family protein
GH266_RS22760	COG3327	negative regulation of DNA-templated transcription, initiation
GH266_RS22765	COG3396	Phenylacetate-CoA oxygenase
GH266_RS22770	COG3460	Phenylacetate-CoA oxygenase
GH266_RS22775	COG3396	Phenylacetate-CoA oxygenase
GH266_RS22780	COG2151	metal-sulfur cluster biosynthetic enzyme
GH266_RS22785	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GH266_RS22800	COG3300	MHYT domain
GH266_RS22800	COG5001	Diguanylate cyclase
GH266_RS22815	COG0179	Fumarylacetoacetate (FAA) hydrolase
GH266_RS22820	COG0513	Belongs to the DEAD box helicase family
GH266_RS22825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GH266_RS22830	COG3962	Belongs to the TPP enzyme family
GH266_RS22840	COG3718	enzyme involved in inositol metabolism
GH266_RS22855	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GH266_RS22865	COG2390	Transcriptional regulator
GH266_RS22875	COG1175	transmembrane transport
GH266_RS22900	COG0546	phosphoglycolate phosphatase activity
GH266_RS22910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GH266_RS22910	COG1017	nitric oxide dioxygenase activity
GH266_RS22930	COG3486	L-lysine 6-monooxygenase (NADPH) activity
GH266_RS22945	COG0477	Major facilitator Superfamily
GH266_RS22950	COG1024	Enoyl-CoA hydratase
GH266_RS22955	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GH266_RS22975	COG1960	acyl-CoA dehydrogenase activity
GH266_RS22980	COG0583	DNA-binding transcription factor activity
GH266_RS22990	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GH266_RS23000	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
GH266_RS23025	COG1522	sequence-specific DNA binding
GH266_RS23050	COG1028	Short-chain dehydrogenase reductase Sdr
GH266_RS23075	COG1960	acyl-CoA dehydrogenase activity
GH266_RS23080	COG1522	sequence-specific DNA binding
GH266_RS23085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GH266_RS23090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GH266_RS23095	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GH266_RS23105	COG0523	cobalamin synthesis protein
GH266_RS23115	COG1121	(ABC) transporter
GH266_RS23120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GH266_RS23125	COG0735	belongs to the Fur family
GH266_RS23130	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
GH266_RS23135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GH266_RS23140	COG4558	Periplasmic binding protein
GH266_RS23145	COG3720	iron ion transport
GH266_RS23150	COG1629	transport
GH266_RS23160	COG0811	peptide transport
GH266_RS23165	COG0848	biopolymer transport protein
GH266_RS23175	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
GH266_RS23190	COG3243	poly(R)-hydroxyalkanoic acid synthase
GH266_RS23200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GH266_RS23205	COG1120	ATPase activity