locus-tag	class	description
G3545_RS00005	COG0358	DNA primase activity
G3545_RS00010	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G3545_RS00030	COG5487	UPF0391 membrane protein
G3545_RS00050	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
G3545_RS00060	COG1877	trehalose-phosphatase activity
G3545_RS00065	COG0488	(ABC) transporter
G3545_RS00090	COG2890	protein-(glutamine-N5) methyltransferase activity
G3545_RS00100	COG4122	O-methyltransferase activity
G3545_RS00145	COG1376	ErfK ybiS ycfS ynhG family protein
G3545_RS00150	COG1720	tRNA m6t6A37 methyltransferase activity
G3545_RS00155	COG2226	methyltransferase
G3545_RS00165	COG2852	Protein conserved in bacteria
G3545_RS00180	COG0154	amidase activity
G3545_RS00185	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
G3545_RS00190	COG0384	phenazine biosynthesis protein PhzF
G3545_RS00205	COG0402	S-adenosylhomocysteine deaminase activity
G3545_RS00215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G3545_RS00220	COG0481	GTPase activity
G3545_RS00225	COG3422	double-strand break repair
G3545_RS00250	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
G3545_RS00255	COG1840	ABC-type Fe3 transport system, periplasmic component
G3545_RS00260	COG3842	ATPase activity
G3545_RS00265	COG1178	ABC-type Fe3 transport system permease component
G3545_RS00300	COG1914	H( )-stimulated, divalent metal cation uptake system
G3545_RS00315	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G3545_RS00335	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G3545_RS00345	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G3545_RS00395	COG1902	pentaerythritol trinitrate reductase activity
G3545_RS00405	COG1566	PFAM secretion protein HlyD family protein
G3545_RS00410	COG2814	Major facilitator Superfamily
G3545_RS00420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G3545_RS00430	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
G3545_RS00455	COG0728	peptidoglycan biosynthetic process
G3545_RS00460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3545_RS00470	COG1396	sequence-specific DNA binding
G3545_RS00485	COG0438	transferase activity, transferring glycosyl groups
G3545_RS00500	COG3795	YCII-related domain
G3545_RS00505	COG0179	Fumarylacetoacetate (FAA) hydrolase
G3545_RS00520	COG0697	spore germination
G3545_RS00530	COG0351	phosphomethylpyrimidine kinase
G3545_RS00535	COG4948	Mandelate Racemase Muconate Lactonizing
G3545_RS00540	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G3545_RS00545	COG1127	ABC transporter
G3545_RS00555	COG3218	ABC-type transport auxiliary lipoprotein component
G3545_RS00555	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G3545_RS00595	COG1404	Belongs to the peptidase S8 family
G3545_RS00605	COG0633	Ferredoxin
G3545_RS00620	COG3768	UPF0283 membrane protein
G3545_RS00625	COG3106	COG3106 Predicted ATPase
G3545_RS00635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3545_RS00650	COG3190	flagellar
G3545_RS00660	COG0166	Belongs to the GPI family
G3545_RS00665	COG0033	Phosphoglucomutase
G3545_RS00670	COG1846	Transcriptional regulator
G3545_RS00675	COG0783	Belongs to the Dps family
G3545_RS00685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3545_RS00695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3545_RS00750	COG1802	Transcriptional regulator
G3545_RS00795	COG1129	ABC transporter
G3545_RS00800	COG1172	Belongs to the binding-protein-dependent transport system permease family
G3545_RS00805	COG1879	ABC-type sugar transport system periplasmic component
G3545_RS00810	COG0693	protein deglycase activity
G3545_RS00820	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G3545_RS00825	COG1335	isochorismatase
G3545_RS00850	COG0604	alcohol dehydrogenase
G3545_RS00850	COG3321	synthase
G3545_RS00850	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS00855	COG2986	histidine ammonia-lyase
G3545_RS00900	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
G3545_RS00905	COG1088	dTDP-glucose 4,6-dehydratase activity
G3545_RS00910	COG1414	Transcriptional regulator
G3545_RS00915	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS00950	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS00970	COG3220	belongs to the UPF0276 family
G3545_RS01005	COG0765	amino acid transport
G3545_RS01010	COG0765	amino acid transport
G3545_RS01020	COG0251	oxidation-reduction process
G3545_RS01035	COG2814	Major facilitator Superfamily
G3545_RS01040	COG0583	DNA-binding transcription factor activity
G3545_RS01060	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G3545_RS01065	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G3545_RS01075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G3545_RS01080	COG0538	isocitrate dehydrogenase activity
G3545_RS01105	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
G3545_RS01120	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
G3545_RS01130	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G3545_RS01135	COG0047	phosphoribosylformylglycinamidine synthase activity
G3545_RS01140	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G3545_RS01145	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
G3545_RS01165	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
G3545_RS01190	COG0517	IMP dehydrogenase activity
G3545_RS01190	COG4175	Glycine betaine
G3545_RS01195	COG3191	aminopeptidase activity
G3545_RS01200	COG0785	Cytochrome C biogenesis protein
G3545_RS01205	COG0683	leucine binding
G3545_RS01235	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G3545_RS01265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3545_RS01285	COG0542	response to heat
G3545_RS01300	COG1509	lysine 2,3-aminomutase activity
G3545_RS01310	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
G3545_RS01310	COG3608	succinylglutamate desuccinylase aspartoacylase
G3545_RS01315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G3545_RS01345	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
G3545_RS01355	COG1178	ABC-type Fe3 transport system permease component
G3545_RS01360	COG1840	ABC-type Fe3 transport system, periplasmic component
G3545_RS01370	COG1309	transcriptional regulator
G3545_RS01375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3545_RS01380	COG1131	(ABC) transporter
G3545_RS01390	COG0459	protein refolding
G3545_RS01395	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
G3545_RS01405	COG5425	PFAM Usg family protein
G3545_RS01410	COG3932	Exopolysaccharide synthesis, ExoD
G3545_RS01415	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS01435	COG1305	Transglutaminase-like
G3545_RS01445	COG1280	lysine exporter protein (LysE YggA)
G3545_RS01450	COG2308	Evidence 4 Homologs of previously reported genes of
G3545_RS01465	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
G3545_RS01490	COG0506	proline dehydrogenase activity
G3545_RS01490	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G3545_RS01490	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G3545_RS01495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G3545_RS01510	COG1794	racemase activity, acting on amino acids and derivatives
G3545_RS01525	COG4302	ethanolamine ammonia-lyase activity
G3545_RS01540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G3545_RS01555	COG2267	carboxylic ester hydrolase activity
G3545_RS01590	COG0517	IMP dehydrogenase activity
G3545_RS01590	COG0516	GMP reductase activity
G3545_RS01595	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G3545_RS01600	COG0302	gtp cyclohydrolase
G3545_RS01620	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
G3545_RS01625	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G3545_RS01635	COG1388	LysM domain
G3545_RS01635	COG1376	ErfK ybiS ycfS ynhG family protein
G3545_RS01645	COG0778	Nitroreductase
G3545_RS01660	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
G3545_RS01665	COG1324	tolerance protein
G3545_RS01675	COG1234	tRNA 3'-trailer cleavage
G3545_RS01685	COG1253	flavin adenine dinucleotide binding
G3545_RS01690	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G3545_RS01700	COG3468	outer membrane autotransporter barrel domain protein
G3545_RS01710	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
G3545_RS01720	COG2188	Transcriptional regulator
G3545_RS01730	COG2205	protein histidine kinase activity
G3545_RS01760	COG3833	ABC-type maltose transport systems, permease component
G3545_RS01765	COG3842	ATPase activity
G3545_RS01780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G3545_RS01840	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
G3545_RS01840	COG3608	succinylglutamate desuccinylase aspartoacylase
G3545_RS01855	COG3387	PFAM Glycoside hydrolase 15-related
G3545_RS01865	COG0405	Gamma-glutamyltransferase
G3545_RS01870	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G3545_RS01880	COG4191	Histidine kinase
G3545_RS01885	COG4566	intracellular signal transduction
G3545_RS01890	COG4566	intracellular signal transduction
G3545_RS01895	COG1959	2 iron, 2 sulfur cluster binding
G3545_RS01900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G3545_RS01935	COG4566	intracellular signal transduction
G3545_RS01940	COG2204	response regulator
G3545_RS01945	COG4566	intracellular signal transduction
G3545_RS01950	COG4191	Histidine kinase
G3545_RS01960	COG1132	(ABC) transporter
G3545_RS01970	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G3545_RS01990	COG0525	valine-tRNA ligase activity
G3545_RS02000	COG0129	dihydroxy-acid dehydratase activity
G3545_RS02025	COG0232	Belongs to the dGTPase family. Type 2 subfamily
G3545_RS02030	COG0018	arginyl-trna synthetase
G3545_RS02040	COG1472	Belongs to the glycosyl hydrolase 3 family
G3545_RS02045	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
G3545_RS02055	COG3842	ATPase activity
G3545_RS02060	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G3545_RS02070	COG0805	protein transport
G3545_RS02075	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
G3545_RS02080	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
G3545_RS02085	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G3545_RS02100	COG1862	Preprotein translocase
G3545_RS02105	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G3545_RS02120	COG1562	ergosterol biosynthetic process
G3545_RS02135	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
G3545_RS02150	COG1832	CoA-binding protein
G3545_RS02170	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G3545_RS02175	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G3545_RS02180	COG3706	GGDEF domain
G3545_RS02185	COG0174	glutamine synthetase
G3545_RS02190	COG0347	Belongs to the P(II) protein family
G3545_RS02195	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
G3545_RS02195	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
G3545_RS02200	COG2132	Multicopper oxidase
G3545_RS02210	COG0544	peptidyl-prolyl cis-trans isomerase activity
G3545_RS02215	COG0740	serine-type endopeptidase activity
G3545_RS02220	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
G3545_RS02225	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G3545_RS02230	COG0776	regulation of translation
G3545_RS02240	COG0546	phosphoglycolate phosphatase activity
G3545_RS02260	COG1295	ribonuclease BN
G3545_RS02275	COG0753	catalase activity
G3545_RS02335	COG0628	permease
G3545_RS02350	COG2094	Belongs to the DNA glycosylase MPG family
G3545_RS02355	COG0626	cystathionine gamma-synthase activity
G3545_RS02400	COG2095	MarC family integral membrane protein
G3545_RS02405	COG3181	Tripartite tricarboxylate transporter family receptor
G3545_RS02440	COG3791	Glutathione-dependent formaldehyde-activating
G3545_RS02455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G3545_RS02485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G3545_RS02520	COG0747	negative chemotaxis
G3545_RS02525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G3545_RS02535	COG4172	Belongs to the ABC transporter superfamily
G3545_RS02550	COG2070	2-Nitropropane dioxygenase
G3545_RS02555	COG3119	arylsulfatase activity
G3545_RS02590	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
G3545_RS02625	COG2309	aminopeptidase activity
G3545_RS02640	COG0739	heme binding
G3545_RS02640	COG0741	lytic transglycosylase activity
G3545_RS02640	COG1196	nuclear chromosome segregation
G3545_RS02645	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G3545_RS02660	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G3545_RS02665	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G3545_RS02675	COG1573	uracil-dna glycosylase
G3545_RS02685	COG1758	RNA polymerase activity
G3545_RS02710	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
G3545_RS02715	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
G3545_RS02720	COG0736	holo-[acyl-carrier-protein] synthase activity
G3545_RS02725	COG0681	Belongs to the peptidase S26 family
G3545_RS02730	COG0571	ribonuclease III activity
G3545_RS02735	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G3545_RS02740	COG1381	Involved in DNA repair and RecF pathway recombination
G3545_RS02750	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
G3545_RS02760	COG1653	transport
G3545_RS02775	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
G3545_RS02780	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
G3545_RS02790	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G3545_RS02795	COG0559	Belongs to the binding-protein-dependent transport system permease family
G3545_RS02800	COG0113	porphobilinogen synthase activity
G3545_RS02805	COG1024	Enoyl-CoA hydratase
G3545_RS02815	COG1846	Transcriptional regulator
G3545_RS02820	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
G3545_RS02825	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
G3545_RS02830	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G3545_RS02830	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G3545_RS02840	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
G3545_RS02845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G3545_RS02850	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
G3545_RS02860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3545_RS02865	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
G3545_RS02885	COG0416	fatty acid biosynthetic process
G3545_RS02890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G3545_RS02895	COG0776	regulation of translation
G3545_RS02905	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
G3545_RS02910	COG1012	belongs to the aldehyde dehydrogenase family
G3545_RS02915	COG0778	Nitroreductase
G3545_RS02940	COG0438	transferase activity, transferring glycosyl groups
G3545_RS02970	COG1612	heme a metabolic process
G3545_RS02975	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G3545_RS02980	COG0629	single-stranded DNA binding
G3545_RS02985	COG2095	MarC family integral membrane protein
G3545_RS02990	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
G3545_RS02995	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G3545_RS03010	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
G3545_RS03025	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
G3545_RS03030	COG0343	queuine tRNA-ribosyltransferase activity
G3545_RS03035	COG0655	NAD(P)H dehydrogenase (quinone) activity
G3545_RS03070	COG1763	Mo-molybdopterin cofactor biosynthetic process
G3545_RS03075	COG0746	molybdenum cofactor guanylyltransferase activity
G3545_RS03080	COG2832	Protein of unknown function (DUF454)
G3545_RS03090	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
G3545_RS03095	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G3545_RS03120	COG0679	Auxin Efflux Carrier
G3545_RS03125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G3545_RS03130	COG1183	phosphatidylcholine synthase activity
G3545_RS03145	COG1172	Belongs to the binding-protein-dependent transport system permease family
G3545_RS03165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G3545_RS03180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G3545_RS03210	COG5002	protein histidine kinase activity
G3545_RS03210	COG2198	Histidine kinase
G3545_RS03210	COG0784	Response regulator, receiver
G3545_RS03215	COG3437	response regulator, receiver
G3545_RS03220	COG3920	Histidine kinase
G3545_RS03225	COG1012	belongs to the aldehyde dehydrogenase family
G3545_RS03230	COG4948	Mandelate Racemase Muconate Lactonizing
G3545_RS03245	COG3842	ATPase activity
G3545_RS03250	COG1176	ABC-type spermidine putrescine transport system, permease component I
G3545_RS03255	COG1177	transmembrane transport
G3545_RS03265	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
G3545_RS03300	COG1335	isochorismatase
G3545_RS03335	COG2084	Dehydrogenase
G3545_RS03360	COG0583	DNA-binding transcription factor activity
G3545_RS03390	COG3706	GGDEF domain
G3545_RS03390	COG4251	negative regulation of phosphorylation
G3545_RS03390	COG5001	Diguanylate cyclase
G3545_RS03390	COG2203	Gaf domain
G3545_RS03430	COG1686	Belongs to the peptidase S11 family
G3545_RS03435	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G3545_RS03440	COG0470	DNA polymerase III
G3545_RS03450	COG0084	hydrolase, TatD family'
G3545_RS03455	COG0321	lipoyl(octanoyl) transferase activity
G3545_RS03455	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
G3545_RS03465	COG3956	TIGRFAM MazG family protein
G3545_RS03475	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G3545_RS03480	COG1923	regulation of RNA biosynthetic process
G3545_RS03485	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G3545_RS03495	COG0569	domain protein
G3545_RS03510	COG2204	response regulator
G3545_RS03515	COG5000	phosphorelay sensor kinase activity
G3545_RS03520	COG2204	response regulator
G3545_RS03535	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
G3545_RS03535	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
G3545_RS03545	COG2867	negative regulation of translational initiation
G3545_RS03550	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
G3545_RS03555	COG2261	transglycosylase associated protein
G3545_RS03560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G3545_RS03565	COG0508	dehydrogenase complex catalyzes the overall conversion of
G3545_RS03570	COG0508	dehydrogenase complex catalyzes the overall conversion of
G3545_RS03570	COG0022	dehydrogenase e1 component
G3545_RS03580	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G3545_RS03590	COG0148	phosphopyruvate hydratase activity
G3545_RS03595	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
G3545_RS03600	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G3545_RS03605	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G3545_RS03640	COG0504	CTP synthase activity
G3545_RS03650	COG0149	triose-phosphate isomerase activity
G3545_RS03660	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
G3545_RS03670	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G3545_RS03675	COG0134	indole-3-glycerol-phosphate synthase activity
G3545_RS03680	COG0315	cyclic pyranopterin monophosphate synthase activity
G3545_RS03685	COG0303	'Molybdopterin
G3545_RS03705	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G3545_RS03715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G3545_RS03720	COG0372	Belongs to the citrate synthase family
G3545_RS03725	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G3545_RS03735	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G3545_RS03740	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G3545_RS03745	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G3545_RS03750	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G3545_RS03755	COG0750	zinc metalloprotease
G3545_RS03765	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G3545_RS03770	COG0233	cytoplasmic translational termination
G3545_RS03775	COG0528	UMP kinase activity
G3545_RS03780	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
G3545_RS03785	COG0052	Belongs to the universal ribosomal protein uS2 family
G3545_RS03795	COG1858	cytochrome C peroxidase
G3545_RS03805	COG1136	(ABC) transporter
G3545_RS03815	COG0442	prolyl-tRNA aminoacylation
G3545_RS03820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G3545_RS03875	COG0726	polysaccharide deacetylase
G3545_RS03935	COG0346	lactoylglutathione lyase activity
G3545_RS03950	COG1007	ATP synthesis coupled electron transport
G3545_RS03965	COG0713	ATP synthesis coupled electron transport
G3545_RS03975	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G3545_RS03985	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
G3545_RS03995	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
G3545_RS04000	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
G3545_RS04005	COG0649	NAD binding
G3545_RS04010	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G3545_RS04015	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G3545_RS04045	COG3474	cytochrome
G3545_RS04080	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
G3545_RS04080	COG0662	Cupin 2, conserved barrel domain protein
G3545_RS04085	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
G3545_RS04095	COG2877	3-deoxy-8-phosphooctulonate synthase activity
G3545_RS04100	COG0625	glutathione transferase activity
G3545_RS04125	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G3545_RS04145	COG0154	amidase activity
G3545_RS04150	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G3545_RS04155	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
G3545_RS04160	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
G3545_RS04175	COG0540	Belongs to the ATCase OTCase family
G3545_RS04185	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
G3545_RS04190	COG0758	DNA mediated transformation
G3545_RS04195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G3545_RS04205	COG0596	Alpha beta hydrolase
G3545_RS04210	COG0557	exoribonuclease II activity
G3545_RS04230	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
G3545_RS04235	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G3545_RS04245	COG0784	Response regulator, receiver
G3545_RS04255	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G3545_RS04280	COG0537	adenosine 5'-monophosphoramidase activity
G3545_RS04300	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
G3545_RS04315	COG1686	Belongs to the peptidase S11 family
G3545_RS04330	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
G3545_RS04365	COG3300	MHYT domain
G3545_RS04365	COG5001	Diguanylate cyclase
G3545_RS04370	COG2239	Acts as a magnesium transporter
G3545_RS04385	COG1254	Belongs to the acylphosphatase family
G3545_RS04390	COG0321	lipoyl(octanoyl) transferase activity
G3545_RS04480	COG3685	Protein conserved in bacteria
G3545_RS04510	COG4221	oxidoreductase activity
G3545_RS04525	COG0071	Belongs to the small heat shock protein (HSP20) family
G3545_RS04600	COG0726	polysaccharide deacetylase
G3545_RS04620	COG1993	acr, cog1993
G3545_RS04635	COG1993	acr, cog1993
G3545_RS04640	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G3545_RS04650	COG0203	ribosomal protein L17
G3545_RS04655	COG0202	RNA polymerase activity
G3545_RS04660	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
G3545_RS04665	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
G3545_RS04670	COG0563	adenylate kinase activity
G3545_RS04675	COG0201	protein transport
G3545_RS04680	COG0200	Binds to the 23S rRNA
G3545_RS04685	COG1841	ribosomal large subunit assembly
G3545_RS04690	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
G3545_RS04695	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
G3545_RS04700	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
G3545_RS04705	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
G3545_RS04710	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
G3545_RS04715	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G3545_RS04720	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
G3545_RS04725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
G3545_RS04730	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
G3545_RS04735	COG0255	Belongs to the universal ribosomal protein uL29 family
G3545_RS04740	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
G3545_RS04745	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
G3545_RS04750	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
G3545_RS04755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
G3545_RS04760	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G3545_RS04765	COG0089	rRNA binding
G3545_RS04770	COG0088	Forms part of the polypeptide exit tunnel
G3545_RS04775	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
G3545_RS04780	COG0051	transcription antitermination factor activity, RNA binding
G3545_RS04785	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G3545_RS04790	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G3545_RS04795	COG0049	tRNA binding
G3545_RS04800	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
G3545_RS04805	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
G3545_RS04810	COG0085	RNA polymerase activity
G3545_RS04815	COG0222	ribosome binding
G3545_RS04820	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
G3545_RS04825	COG0081	regulation of translation
G3545_RS04830	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
G3545_RS04840	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G3545_RS04850	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G3545_RS04870	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G3545_RS04880	COG0251	oxidation-reduction process
G3545_RS04900	COG0582	viral genome integration into host DNA
G3545_RS04910	COG1058	Belongs to the CinA family
G3545_RS04910	COG1546	Belongs to the CinA family
G3545_RS04930	COG4651	solute:proton antiporter activity
G3545_RS04930	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G3545_RS04990	COG0387	Pfam Sodium calcium exchanger
G3545_RS04995	COG0598	Magnesium transport protein CorA
G3545_RS05035	COG2304	oxidoreductase activity
G3545_RS05050	COG0714	Associated with various cellular activities
G3545_RS05055	COG3851	Histidine kinase
G3545_RS05060	COG2197	response regulator
G3545_RS05065	COG3386	PFAM SMP-30 Gluconolaconase
G3545_RS05075	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS05120	COG0714	Associated with various cellular activities
G3545_RS05140	COG3119	arylsulfatase activity
G3545_RS05145	COG3119	arylsulfatase activity
G3545_RS05150	COG1566	PFAM secretion protein HlyD family protein
G3545_RS05165	COG3119	arylsulfatase activity
G3545_RS05170	COG0583	DNA-binding transcription factor activity
G3545_RS05200	COG1178	ABC-type Fe3 transport system permease component
G3545_RS05205	COG1840	ABC-type Fe3 transport system, periplasmic component
G3545_RS05210	COG3842	ATPase activity
G3545_RS05220	COG1132	(ABC) transporter
G3545_RS05255	COG0300	oxidoreductase activity
G3545_RS05260	COG0415	Belongs to the DNA photolyase family
G3545_RS05275	COG2897	thiosulfate sulfurtransferase activity
G3545_RS05295	COG1126	abc transporter atp-binding protein
G3545_RS05300	COG0765	amino acid transport
G3545_RS05305	COG4597	amino acid ABC transporter
G3545_RS05310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G3545_RS05320	COG0626	cystathionine gamma-synthase activity
G3545_RS05330	COG0463	Glycosyl transferase, family 2
G3545_RS05345	COG4221	oxidoreductase activity
G3545_RS05350	COG0667	Aldo Keto reductase
G3545_RS05375	COG3300	MHYT domain
G3545_RS05375	COG5001	Diguanylate cyclase
G3545_RS05380	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
G3545_RS05385	COG0830	nickel cation binding
G3545_RS05390	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
G3545_RS05395	COG0804	urea catabolic process
G3545_RS05410	COG0832	Belongs to the urease beta subunit family
G3545_RS05410	COG0831	urea catabolic process
G3545_RS05415	COG0829	nickel cation binding
G3545_RS05435	COG0559	Belongs to the binding-protein-dependent transport system permease family
G3545_RS05450	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
G3545_RS05485	COG0300	oxidoreductase activity
G3545_RS05495	COG3263	regulation of cellular component size
G3545_RS05505	COG1309	transcriptional regulator
G3545_RS05510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G3545_RS05515	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G3545_RS05535	COG0697	spore germination
G3545_RS05555	COG1494	fructose-1,6-bisphosphatase
G3545_RS05565	COG0436	Aminotransferase
G3545_RS05575	COG3243	poly(R)-hydroxyalkanoic acid synthase
G3545_RS05585	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
G3545_RS05595	COG0187	DNA topoisomerase II activity
G3545_RS05610	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G3545_RS05615	COG0513	Belongs to the DEAD box helicase family
G3545_RS05620	COG0668	transmembrane transport
G3545_RS05630	COG0316	Belongs to the HesB IscA family
G3545_RS05640	COG2151	metal-sulfur cluster biosynthetic enzyme
G3545_RS05645	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G3545_RS05650	COG0719	Fe-S assembly protein
G3545_RS05655	COG0396	ATPase activity
G3545_RS05660	COG0719	Fe-S assembly protein
G3545_RS05665	COG1104	cysteine desulfurase activity
G3545_RS05670	COG2945	thiolester hydrolase activity
G3545_RS05680	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
G3545_RS05685	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G3545_RS05690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G3545_RS05700	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G3545_RS05705	COG0739	heme binding
G3545_RS05730	COG0860	N-Acetylmuramoyl-L-alanine amidase
G3545_RS05735	COG1530	ribonuclease E activity
G3545_RS05745	COG0436	Aminotransferase
G3545_RS05750	COG0501	Belongs to the peptidase M48B family
G3545_RS05760	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
G3545_RS05765	COG0511	ligase activity, forming carbon-carbon bonds
G3545_RS05775	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
G3545_RS05805	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G3545_RS05810	COG1278	Cold shock
G3545_RS05815	COG1278	Cold shock
G3545_RS05830	COG0281	malic enzyme
G3545_RS05830	COG0280	phosphate acetyltransferase
G3545_RS05840	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
G3545_RS05855	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
G3545_RS05860	COG0583	DNA-binding transcription factor activity
G3545_RS05870	COG0248	Ppx GppA phosphatase
G3545_RS05875	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
G3545_RS05885	COG0628	permease
G3545_RS05890	COG2205	protein histidine kinase activity
G3545_RS05890	COG4191	Histidine kinase
G3545_RS05890	COG0745	RESPONSE REGULATOR receiver
G3545_RS05895	COG4566	intracellular signal transduction
G3545_RS05905	COG3119	arylsulfatase activity
G3545_RS05915	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G3545_RS05925	COG3135	benzoate transporter
G3545_RS05930	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
G3545_RS05935	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G3545_RS05945	COG0243	molybdopterin cofactor binding
G3545_RS05950	COG0861	Integral membrane protein TerC family
G3545_RS05955	COG0861	Integral membrane protein TerC family
G3545_RS05960	COG0105	UTP biosynthetic process
G3545_RS05980	COG0477	Major facilitator Superfamily
G3545_RS05990	COG0300	oxidoreductase activity
G3545_RS06005	COG2080	2 iron, 2 sulfur cluster binding
G3545_RS06010	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
G3545_RS06015	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G3545_RS06045	COG4191	Histidine kinase
G3545_RS06045	COG0784	Response regulator, receiver
G3545_RS06070	COG2198	Histidine kinase
G3545_RS06070	COG0643	Histidine kinase
G3545_RS06075	COG0745	RESPONSE REGULATOR receiver
G3545_RS06080	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
G3545_RS06090	COG2201	protein-glutamate methylesterase activity
G3545_RS06095	COG0835	chemotaxis
G3545_RS06100	COG0840	transmembrane signaling receptor activity
G3545_RS06100	COG3290	protein histidine kinase activity
G3545_RS06125	COG3181	Tripartite tricarboxylate transporter family receptor
G3545_RS06170	COG1404	Belongs to the peptidase S8 family
G3545_RS06240	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
G3545_RS06265	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS06315	COG0488	(ABC) transporter
G3545_RS06330	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G3545_RS06345	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
G3545_RS06355	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G3545_RS06360	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G3545_RS06375	COG0194	GDP metabolic process
G3545_RS06380	COG1561	YicC-like family, N-terminal region
G3545_RS06385	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G3545_RS06390	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G3545_RS06395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G3545_RS06405	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
G3545_RS06420	COG0360	Binds together with S18 to 16S ribosomal RNA
G3545_RS06425	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G3545_RS06435	COG0359	binds to the 23S rRNA
G3545_RS06440	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G3545_RS06445	COG0305	Participates in initiation and elongation during chromosome replication
G3545_RS06450	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G3545_RS06460	COG1286	toxin biosynthetic process
G3545_RS06465	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
G3545_RS06475	COG0300	oxidoreductase activity
G3545_RS06480	COG1160	GTP binding
G3545_RS06495	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
G3545_RS06525	COG3706	GGDEF domain
G3545_RS06550	COG1393	Belongs to the ArsC family
G3545_RS06595	COG0420	3'-5' exonuclease activity
G3545_RS06645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G3545_RS06650	COG2368	4-hydroxyphenylacetate
G3545_RS06685	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
G3545_RS06690	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G3545_RS06695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G3545_RS06710	COG1672	PFAM Archaeal ATPase
G3545_RS06710	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
G3545_RS06740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G3545_RS06765	COG1176	ABC-type spermidine putrescine transport system, permease component I
G3545_RS06770	COG1177	transmembrane transport
G3545_RS06775	COG3842	ATPase activity
G3545_RS06780	COG0590	tRNA wobble adenosine to inosine editing
G3545_RS06785	COG1802	Transcriptional regulator
G3545_RS06790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G3545_RS06795	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
G3545_RS06805	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
G3545_RS06810	COG1984	allophanate hydrolase subunit 2
G3545_RS06815	COG2188	Transcriptional regulator
G3545_RS06860	COG0789	Transcriptional regulator
G3545_RS06870	COG0583	DNA-binding transcription factor activity
G3545_RS06890	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
G3545_RS06895	COG3842	ATPase activity
G3545_RS06900	COG3842	ATPase activity
G3545_RS06905	COG1920	GTP binding
G3545_RS06910	COG0391	Required for morphogenesis under gluconeogenic growth conditions
G3545_RS06915	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
G3545_RS06915	COG0778	Nitroreductase
G3545_RS06920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G3545_RS06925	COG2249	NAD(P)H dehydrogenase (quinone) activity
G3545_RS06935	COG0625	glutathione transferase activity
G3545_RS06945	COG0330	HflC and HflK could
G3545_RS06970	COG0583	DNA-binding transcription factor activity
G3545_RS06980	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
G3545_RS07050	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G3545_RS07060	COG2814	Major facilitator Superfamily
G3545_RS07080	COG1230	cation diffusion facilitator family transporter
G3545_RS07085	COG2853	Lipoprotein
G3545_RS07115	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
G3545_RS07180	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS07185	COG2207	Transcriptional regulator
G3545_RS07200	COG3485	protocatechuate 3,4-dioxygenase
G3545_RS07210	COG0318	PFAM AMP-dependent synthetase and ligase
G3545_RS07235	COG1032	radical SAM domain protein
G3545_RS07245	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G3545_RS07260	COG0446	pyridine nucleotide-disulphide oxidoreductase
G3545_RS07260	COG1902	pentaerythritol trinitrate reductase activity
G3545_RS07265	COG0583	DNA-binding transcription factor activity
G3545_RS07315	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G3545_RS07315	COG0519	Catalyzes the synthesis of GMP from XMP
G3545_RS07335	COG3685	Protein conserved in bacteria
G3545_RS07360	COG1116	anion transmembrane transporter activity
G3545_RS07370	COG4191	Histidine kinase
G3545_RS07375	COG4566	intracellular signal transduction
G3545_RS07385	COG0477	Major facilitator Superfamily
G3545_RS07390	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
G3545_RS07415	COG1012	belongs to the aldehyde dehydrogenase family
G3545_RS07435	COG0402	S-adenosylhomocysteine deaminase activity
G3545_RS07440	COG0402	S-adenosylhomocysteine deaminase activity
G3545_RS07445	COG1228	amidohydrolase
G3545_RS07450	COG2986	histidine ammonia-lyase
G3545_RS07460	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
G3545_RS07475	COG0670	Belongs to the BI1 family
G3545_RS07485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G3545_RS07500	COG0765	amino acid transport
G3545_RS07505	COG1126	abc transporter atp-binding protein
G3545_RS07520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G3545_RS07535	COG1902	pentaerythritol trinitrate reductase activity
G3545_RS07550	COG1802	Transcriptional regulator
G3545_RS07560	COG1126	abc transporter atp-binding protein
G3545_RS07570	COG0765	amino acid transport
G3545_RS07575	COG0765	amino acid transport
G3545_RS07625	COG4953	penicillin-binding protein 1C
G3545_RS07630	COG2373	Large extracellular alpha-helical protein
G3545_RS07635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G3545_RS07640	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G3545_RS07645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G3545_RS07650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G3545_RS07675	COG0174	glutamine synthetase
G3545_RS07720	COG2132	Multicopper oxidase
G3545_RS07725	COG4221	oxidoreductase activity
G3545_RS07740	COG1183	phosphatidylcholine synthase activity
G3545_RS07745	COG0688	phosphatidylethanolamine metabolic process
G3545_RS07750	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G3545_RS07750	COG2169	Transcriptional regulator
G3545_RS07760	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G3545_RS07785	COG3258	Cytochrome c
G3545_RS07860	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
G3545_RS07870	COG0058	SHG alpha-glucan phosphorylase activity
G3545_RS07875	COG0456	acetyltransferase
G3545_RS07905	COG0488	(ABC) transporter
G3545_RS07930	COG2186	Transcriptional regulator
G3545_RS07935	COG0747	negative chemotaxis
G3545_RS07950	COG4172	Belongs to the ABC transporter superfamily
G3545_RS07955	COG1733	regulation of RNA biosynthetic process
G3545_RS07960	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS07970	COG0697	spore germination
G3545_RS07975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G3545_RS07980	COG0783	Belongs to the Dps family
G3545_RS08005	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G3545_RS08005	COG2010	Cytochrome c
G3545_RS08035	COG0318	PFAM AMP-dependent synthetase and ligase
G3545_RS08050	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
G3545_RS08055	COG3034	peptidoglycan biosynthetic process
G3545_RS08065	COG0745	RESPONSE REGULATOR receiver
G3545_RS08080	COG1764	response to oxidative stress
G3545_RS08090	COG1733	regulation of RNA biosynthetic process
G3545_RS08100	COG4941	Belongs to the sigma-70 factor family
G3545_RS08165	COG5265	(ABC) transporter
G3545_RS08180	COG0668	transmembrane transport
G3545_RS08185	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G3545_RS08190	COG0215	cysteine-tRNA ligase activity
G3545_RS08200	COG3045	CreA protein
G3545_RS08210	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
G3545_RS08210	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G3545_RS08225	COG1733	regulation of RNA biosynthetic process
G3545_RS08230	COG0604	alcohol dehydrogenase
G3545_RS08240	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
G3545_RS08250	COG3181	Tripartite tricarboxylate transporter family receptor
G3545_RS08270	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
G3545_RS08280	COG0546	phosphoglycolate phosphatase activity
G3545_RS08340	COG3119	arylsulfatase activity
G3545_RS08345	COG5634	Uncharacterized conserved protein (DUF2278)
G3545_RS08350	COG0438	transferase activity, transferring glycosyl groups
G3545_RS08365	COG0277	FAD linked oxidase domain protein
G3545_RS08395	COG3179	chitinase
G3545_RS08445	COG2226	methyltransferase
G3545_RS08785	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS08805	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G3545_RS08810	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
G3545_RS08815	COG2080	2 iron, 2 sulfur cluster binding
G3545_RS08820	COG0076	glutamate decarboxylase activity
G3545_RS08850	COG3756	Protein conserved in bacteria
G3545_RS08855	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G3545_RS08865	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G3545_RS08890	COG1376	ErfK ybiS ycfS ynhG family protein
G3545_RS08905	COG2827	Endonuclease containing a URI domain
G3545_RS08910	COG2814	Major facilitator Superfamily
G3545_RS08915	COG0697	spore germination
G3545_RS08920	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
G3545_RS08925	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
G3545_RS08930	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
G3545_RS08935	COG0489	protein tyrosine kinase activity
G3545_RS08940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G3545_RS08955	COG1573	uracil-dna glycosylase
G3545_RS08980	COG2202	Pas domain
G3545_RS08980	COG2205	protein histidine kinase activity
G3545_RS08985	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
G3545_RS08990	COG0778	Nitroreductase
G3545_RS08995	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
G3545_RS09010	COG0730	response to heat
G3545_RS09035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G3545_RS09040	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G3545_RS09055	COG0395	ABC-type sugar transport system, permease component
G3545_RS09065	COG3842	ATPase activity
G3545_RS09070	COG3842	ATPase activity
G3545_RS09075	COG0028	Belongs to the TPP enzyme family
G3545_RS09085	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
G3545_RS09090	COG2188	Transcriptional regulator
G3545_RS09100	COG1012	belongs to the aldehyde dehydrogenase family
G3545_RS09105	COG3284	Transcriptional regulator
G3545_RS09110	COG4166	transmembrane transport
G3545_RS09115	COG0601	transmembrane transport
G3545_RS09120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G3545_RS09125	COG4172	Belongs to the ABC transporter superfamily
G3545_RS09135	COG0579	oxidoreductase
G3545_RS09150	COG3181	Tripartite tricarboxylate transporter family receptor
G3545_RS09155	COG4948	Mandelate Racemase Muconate Lactonizing
G3545_RS09160	COG2186	Transcriptional regulator
G3545_RS09165	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
G3545_RS09185	COG2084	Dehydrogenase
G3545_RS09195	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
G3545_RS09210	COG1566	PFAM secretion protein HlyD family protein
G3545_RS09220	COG1289	transmembrane transporter activity
G3545_RS09230	COG0604	alcohol dehydrogenase
G3545_RS09245	COG0625	glutathione transferase activity
G3545_RS09265	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G3545_RS09285	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
G3545_RS09305	COG0596	Alpha beta hydrolase
G3545_RS09315	COG0596	Alpha beta hydrolase
G3545_RS09320	COG1764	response to oxidative stress
G3545_RS09345	COG3246	L-lysine catabolic process to acetate
G3545_RS09350	COG1250	3-hydroxyacyl-CoA dehydrogenase
G3545_RS09350	COG0824	Thioesterase
G3545_RS09375	COG3842	ATPase activity
G3545_RS09395	COG1522	sequence-specific DNA binding
G3545_RS09450	COG1674	ftsk spoiiie
G3545_RS09460	COG1285	pathogenesis
G3545_RS09475	COG3214	Protein conserved in bacteria
G3545_RS09480	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G3545_RS09490	COG1959	2 iron, 2 sulfur cluster binding
G3545_RS09495	COG1803	Methylglyoxal synthase
G3545_RS09515	COG0277	FAD linked oxidase domain protein
G3545_RS09525	COG0848	biopolymer transport protein
G3545_RS09535	COG1960	acyl-CoA dehydrogenase activity
G3545_RS09550	COG3609	addiction module antidote protein, CC2985 family
G3545_RS09570	COG0535	radical SAM domain protein
G3545_RS09575	COG0535	radical SAM domain protein
G3545_RS09580	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
G3545_RS09585	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
G3545_RS09600	COG2205	protein histidine kinase activity
G3545_RS09625	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
G3545_RS09630	COG2076	Multidrug Resistance protein
G3545_RS09635	COG1116	anion transmembrane transporter activity
G3545_RS09645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G3545_RS09665	COG1131	(ABC) transporter
G3545_RS09710	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G3545_RS09740	COG2239	Acts as a magnesium transporter
G3545_RS09755	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
G3545_RS09760	COG1229	Formylmethanofuran dehydrogenase subunit A
G3545_RS09770	COG2154	pterin-4-alpha-carbinolamine dehydratase
G3545_RS09780	COG0702	epimerase
G3545_RS09795	COG1181	Belongs to the D-alanine--D-alanine ligase family
G3545_RS09805	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
G3545_RS09820	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
G3545_RS09830	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
G3545_RS09840	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
G3545_RS09850	COG1850	ribulose-bisphosphate carboxylase activity
G3545_RS09855	COG4451	ribulose bisphosphate carboxylase, small
G3545_RS09875	COG0308	aminopeptidase N
G3545_RS09880	COG3706	GGDEF domain
G3545_RS09880	COG2203	Gaf domain
G3545_RS09880	COG5001	Diguanylate cyclase
G3545_RS09880	COG4251	negative regulation of phosphorylation
G3545_RS09885	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
G3545_RS09890	COG2205	protein histidine kinase activity
G3545_RS09890	COG2202	Pas domain
G3545_RS09895	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
G3545_RS09905	COG0745	RESPONSE REGULATOR receiver
G3545_RS09910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G3545_RS09915	COG3088	subunit of a heme lyase
G3545_RS09920	COG1138	Cytochrome C-type biogenesis protein
G3545_RS09925	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
G3545_RS09930	COG4235	cytochrome complex assembly
G3545_RS09940	COG2205	protein histidine kinase activity
G3545_RS09945	COG0745	RESPONSE REGULATOR receiver
G3545_RS09955	COG5640	endopeptidase activity
G3545_RS09985	COG0717	Belongs to the dCTP deaminase family
G3545_RS09990	COG3474	cytochrome
G3545_RS10005	COG2983	Belongs to the UPF0260 family
G3545_RS10025	COG0443	Heat shock 70 kDa protein
G3545_RS10080	COG2205	protein histidine kinase activity
G3545_RS10090	COG2166	iron-sulfur cluster assembly
G3545_RS10100	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G3545_RS10115	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G3545_RS10130	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G3545_RS10135	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
G3545_RS10140	COG0433	COG0433 Predicted ATPase
G3545_RS10145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G3545_RS10160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G3545_RS10165	COG3237	CsbD-like
G3545_RS10170	COG0784	Response regulator, receiver
G3545_RS10190	COG0730	response to heat
G3545_RS10225	COG0387	Pfam Sodium calcium exchanger
G3545_RS10250	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
G3545_RS10275	COG0483	inositol monophosphate 1-phosphatase activity
G3545_RS10290	COG1519	Transferase
G3545_RS10295	COG1663	tetraacyldisaccharide 4'-kinase activity
G3545_RS10300	COG3685	Protein conserved in bacteria
G3545_RS10310	COG1366	Belongs to the anti-sigma-factor antagonist family
G3545_RS10335	COG2770	Histidine kinase
G3545_RS10335	COG2208	phosphoserine phosphatase activity
G3545_RS10345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G3545_RS10355	COG0431	NADPH-dependent FMN reductase
G3545_RS10370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3545_RS10385	COG4941	Belongs to the sigma-70 factor family
G3545_RS10390	COG3795	YCII-related domain
G3545_RS10410	COG1785	Belongs to the alkaline phosphatase family
G3545_RS10420	COG1136	(ABC) transporter
G3545_RS10435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3545_RS10440	COG1116	anion transmembrane transporter activity
G3545_RS10475	COG0410	ABC transporter
G3545_RS10490	COG3300	MHYT domain
G3545_RS10490	COG5001	Diguanylate cyclase
G3545_RS10505	COG2226	methyltransferase
G3545_RS10545	COG0010	Belongs to the arginase family
G3545_RS10555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G3545_RS10570	COG3961	Belongs to the TPP enzyme family
G3545_RS10575	COG4948	Mandelate Racemase Muconate Lactonizing
G3545_RS10580	COG4948	Mandelate Racemase Muconate Lactonizing
G3545_RS10640	COG0628	permease
G3545_RS10680	COG1320	monovalent cation:proton antiporter activity
G3545_RS10700	COG0651	ATP synthesis coupled electron transport
G3545_RS10720	COG2235	arginine
G3545_RS10740	COG0534	Mate efflux family protein
G3545_RS10745	COG2610	gluconate transmembrane transporter activity
G3545_RS10760	COG0583	DNA-binding transcription factor activity
G3545_RS10765	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS10775	COG2814	Major facilitator Superfamily
G3545_RS10780	COG0656	L-ascorbic acid biosynthetic process
G3545_RS10785	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS10805	COG1053	succinate dehydrogenase
G3545_RS10810	COG1175	transmembrane transport
G3545_RS10820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G3545_RS10825	COG0745	RESPONSE REGULATOR receiver
G3545_RS10840	COG2186	Transcriptional regulator
G3545_RS10855	COG0523	cobalamin synthesis protein
G3545_RS10860	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS10870	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS10875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G3545_RS10880	COG4172	Belongs to the ABC transporter superfamily
G3545_RS10890	COG0601	transmembrane transport
G3545_RS10895	COG0747	negative chemotaxis
G3545_RS10900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G3545_RS10910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G3545_RS10915	COG1126	abc transporter atp-binding protein
G3545_RS10920	COG0765	amino acid transport
G3545_RS10925	COG0765	amino acid transport
G3545_RS10930	COG2084	Dehydrogenase
G3545_RS10935	COG2186	Transcriptional regulator
G3545_RS10945	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
G3545_RS10955	COG5265	(ABC) transporter
G3545_RS10995	COG0784	Response regulator, receiver
G3545_RS10995	COG4191	Histidine kinase
G3545_RS11005	COG0667	Aldo Keto reductase
G3545_RS11025	COG3842	ATPase activity
G3545_RS11050	COG1802	Transcriptional regulator
G3545_RS11055	COG1012	belongs to the aldehyde dehydrogenase family
G3545_RS11060	COG3622	Belongs to the hyi family
G3545_RS11070	COG0395	ABC-type sugar transport system, permease component
G3545_RS11080	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS11125	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS11130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G3545_RS11145	COG3181	Tripartite tricarboxylate transporter family receptor
G3545_RS11155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G3545_RS11170	COG0596	Alpha beta hydrolase
G3545_RS11175	COG1024	Enoyl-CoA hydratase
G3545_RS11185	COG4948	Mandelate Racemase Muconate Lactonizing
G3545_RS11210	COG1566	PFAM secretion protein HlyD family protein
G3545_RS11230	COG0583	DNA-binding transcription factor activity
G3545_RS11235	COG2814	Major facilitator Superfamily
G3545_RS11245	COG1176	ABC-type spermidine putrescine transport system, permease component I
G3545_RS11250	COG3842	ATPase activity
G3545_RS11260	COG1917	Cupin 2, conserved barrel domain protein
G3545_RS11260	COG1396	sequence-specific DNA binding
G3545_RS11265	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G3545_RS11270	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G3545_RS11275	COG0483	inositol monophosphate 1-phosphatase activity
G3545_RS11280	COG1609	Transcriptional regulator
G3545_RS11290	COG1176	ABC-type spermidine putrescine transport system, permease component I
G3545_RS11300	COG3842	ATPase activity
G3545_RS11310	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G3545_RS11310	COG2080	2 iron, 2 sulfur cluster binding
G3545_RS11315	COG3224	Antibiotic biosynthesis monooxygenase
G3545_RS11320	COG1278	Cold shock
G3545_RS11365	COG1276	copper resistance
G3545_RS11370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3545_RS11375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G3545_RS11395	COG4191	Histidine kinase
G3545_RS11400	COG4566	intracellular signal transduction
G3545_RS11405	COG4566	intracellular signal transduction
G3545_RS11420	COG1764	response to oxidative stress
G3545_RS11450	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS11455	COG0583	DNA-binding transcription factor activity
G3545_RS11460	COG1902	pentaerythritol trinitrate reductase activity
G3545_RS11470	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS11480	COG1172	Belongs to the binding-protein-dependent transport system permease family
G3545_RS11485	COG1172	Belongs to the binding-protein-dependent transport system permease family
G3545_RS11490	COG1129	ABC transporter
G3545_RS11505	COG0625	glutathione transferase activity
G3545_RS11515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G3545_RS11520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G3545_RS11525	COG2031	fatty acid transporter
G3545_RS11535	COG1522	sequence-specific DNA binding
G3545_RS11540	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G3545_RS11545	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3545_RS11555	COG2223	nitrite transmembrane transporter activity
G3545_RS11560	COG3284	Transcriptional regulator
G3545_RS11570	COG3842	ATPase activity
G3545_RS11575	COG1177	transmembrane transport
G3545_RS11580	COG1176	ABC-type spermidine putrescine transport system, permease component I
G3545_RS11600	COG1012	belongs to the aldehyde dehydrogenase family
G3545_RS11610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3545_RS11615	COG0583	DNA-binding transcription factor activity
G3545_RS11640	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS11645	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G3545_RS11650	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
G3545_RS11665	COG0596	Alpha beta hydrolase
G3545_RS11675	COG1280	lysine exporter protein (LysE YggA)
G3545_RS11685	COG1012	belongs to the aldehyde dehydrogenase family
G3545_RS11690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3545_RS11695	COG1129	ABC transporter
G3545_RS11695	COG0842	Transport permease protein
G3545_RS11700	COG0842	Transport permease protein
G3545_RS11715	COG2235	arginine
G3545_RS11740	COG3278	Belongs to the heme-copper respiratory oxidase family
G3545_RS11755	COG2010	Cytochrome c
G3545_RS11760	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
G3545_RS11765	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
G3545_RS11770	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
G3545_RS11775	COG1959	2 iron, 2 sulfur cluster binding
G3545_RS11780	COG2346	COG2346, Truncated hemoglobins
G3545_RS11785	COG1017	nitric oxide dioxygenase activity
G3545_RS11785	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G3545_RS11795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G3545_RS11870	COG2217	Heavy metal translocating P-type atpase
G3545_RS11885	COG3842	ATPase activity
G3545_RS11895	COG4149	molybdate abc transporter
G3545_RS11905	COG1088	dTDP-glucose 4,6-dehydratase activity
G3545_RS11925	COG0230	Belongs to the bacterial ribosomal protein bL34 family
G3545_RS11930	COG0594	ribonuclease P activity
G3545_RS11935	COG0706	membrane insertase activity
G3545_RS11940	COG0218	Necessary for normal cell division and for the maintenance of normal septation
G3545_RS11945	COG1063	alcohol dehydrogenase
G3545_RS11950	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G3545_RS11955	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
G3545_RS11960	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
G3545_RS11970	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
G3545_RS11980	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G3545_RS12000	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
G3545_RS12010	COG1376	ErfK ybiS ycfS ynhG family protein
G3545_RS12010	COG1388	LysM domain
G3545_RS12025	COG0583	DNA-binding transcription factor activity
G3545_RS12035	COG0174	glutamine synthetase
G3545_RS12040	COG3842	ATPase activity
G3545_RS12045	COG1176	ABC-type spermidine putrescine transport system, permease component I
G3545_RS12050	COG1177	transmembrane transport
G3545_RS12055	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
G3545_RS12060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3545_RS12065	COG0586	Pfam SNARE associated Golgi protein
G3545_RS12080	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
G3545_RS12085	COG0440	acetolactate synthase activity
G3545_RS12090	COG0028	Belongs to the TPP enzyme family
G3545_RS12095	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
G3545_RS12100	COG0588	phosphoglycerate mutase activity
G3545_RS12120	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G3545_RS12140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G3545_RS12140	COG0072	phenylalanine-tRNA ligase activity
G3545_RS12145	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
G3545_RS12150	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
G3545_RS12155	COG0291	Belongs to the bacterial ribosomal protein bL35 family
G3545_RS12165	COG1968	undecaprenyl-diphosphatase activity
G3545_RS12265	COG2358	TRAP transporter, solute receptor (TAXI family
G3545_RS12275	COG1053	succinate dehydrogenase
G3545_RS12275	COG3976	FMN-binding domain protein
G3545_RS12285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3545_RS12295	COG1116	anion transmembrane transporter activity
G3545_RS12320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3545_RS12325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G3545_RS12335	COG4178	(ABC) transporter
G3545_RS12345	COG3639	organic phosphonate transmembrane transporter activity
G3545_RS12350	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
G3545_RS12355	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
G3545_RS12380	COG1278	Cold shock
G3545_RS12385	COG0828	Belongs to the bacterial ribosomal protein bS21 family
G3545_RS12395	COG1573	uracil-dna glycosylase
G3545_RS12400	COG1271	oxidase subunit
G3545_RS12405	COG1294	oxidase, subunit
G3545_RS12415	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G3545_RS12420	COG2095	MarC family integral membrane protein
G3545_RS12425	COG0412	Dienelactone hydrolase
G3545_RS12430	COG0459	protein refolding
G3545_RS12460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G3545_RS12470	COG1840	ABC-type Fe3 transport system, periplasmic component
G3545_RS12485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G3545_RS12490	COG0612	Peptidase, M16
G3545_RS12500	COG3346	SURF1 family
G3545_RS12515	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
G3545_RS12525	COG0109	protoheme IX farnesyltransferase activity
G3545_RS12530	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G3545_RS12535	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G3545_RS12550	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G3545_RS12555	COG1024	Enoyl-CoA hydratase
G3545_RS12560	COG0268	Binds directly to 16S ribosomal RNA
G3545_RS12565	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G3545_RS12575	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G3545_RS12600	COG0028	Belongs to the TPP enzyme family
G3545_RS12620	COG0625	glutathione transferase activity
G3545_RS12630	COG1999	signal sequence binding
G3545_RS12645	COG5001	Diguanylate cyclase
G3545_RS12645	COG5002	protein histidine kinase activity
G3545_RS12655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G3545_RS12660	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS12665	COG0625	glutathione transferase activity
G3545_RS12675	COG1376	ErfK ybiS ycfS ynhG family protein
G3545_RS12685	COG0583	DNA-binding transcription factor activity
G3545_RS12700	COG0747	negative chemotaxis
G3545_RS12730	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G3545_RS12735	COG0667	Aldo Keto reductase
G3545_RS12740	COG3246	L-lysine catabolic process to acetate
G3545_RS12745	COG1802	Transcriptional regulator
G3545_RS12770	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
G3545_RS12775	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
G3545_RS12795	COG3181	Tripartite tricarboxylate transporter family receptor
G3545_RS12800	COG0583	DNA-binding transcription factor activity
G3545_RS12805	COG1279	arginine transmembrane transporter activity
G3545_RS12825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G3545_RS12830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3545_RS12840	COG1012	belongs to the aldehyde dehydrogenase family
G3545_RS12845	COG1177	transmembrane transport
G3545_RS12850	COG1176	ABC-type spermidine putrescine transport system, permease component I
G3545_RS12855	COG3842	ATPase activity
G3545_RS12860	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
G3545_RS12875	COG0583	DNA-binding transcription factor activity
G3545_RS12890	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
G3545_RS12895	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G3545_RS12900	COG0509	glycine decarboxylation via glycine cleavage system
G3545_RS12905	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G3545_RS12905	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G3545_RS12925	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G3545_RS12940	COG0395	ABC-type sugar transport system, permease component
G3545_RS12950	COG3842	ATPase activity
G3545_RS12955	COG3842	ATPase activity
G3545_RS12975	COG0318	PFAM AMP-dependent synthetase and ligase
G3545_RS12980	COG1268	BioY protein
G3545_RS12985	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
G3545_RS12990	COG1122	ATPase activity
G3545_RS12995	COG0656	L-ascorbic acid biosynthetic process
G3545_RS13010	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
G3545_RS13030	COG0154	amidase activity
G3545_RS13035	COG4447	cellulose binding
G3545_RS13035	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
G3545_RS13040	COG0318	PFAM AMP-dependent synthetase and ligase
G3545_RS13045	COG2132	Multicopper oxidase
G3545_RS13050	COG1937	Protein conserved in bacteria
G3545_RS13065	COG2723	6-phospho-beta-galactosidase activity
G3545_RS13070	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G3545_RS13085	COG0583	DNA-binding transcription factor activity
G3545_RS13090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3545_RS13100	COG0446	pyridine nucleotide-disulphide oxidoreductase
G3545_RS13100	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G3545_RS13115	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G3545_RS13120	COG0477	Major facilitator Superfamily
G3545_RS13135	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
G3545_RS13145	COG0069	glutamate synthase activity
G3545_RS13165	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G3545_RS13170	COG4770	biotin carboxylase activity
G3545_RS13200	COG2186	Transcriptional regulator
G3545_RS13205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G3545_RS13210	COG0765	amino acid transport
G3545_RS13225	COG0583	DNA-binding transcription factor activity
G3545_RS13245	COG1732	Glycine betaine
G3545_RS13280	COG0438	transferase activity, transferring glycosyl groups
G3545_RS13320	COG0579	oxidoreductase
G3545_RS13325	COG4221	oxidoreductase activity
G3545_RS13330	COG2207	Transcriptional regulator
G3545_RS13345	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G3545_RS13355	COG1802	Transcriptional regulator
G3545_RS13360	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
G3545_RS13365	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS13405	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
G3545_RS13415	COG0583	DNA-binding transcription factor activity
G3545_RS13420	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G3545_RS13425	COG0673	inositol 2-dehydrogenase activity
G3545_RS13435	COG0583	DNA-binding transcription factor activity
G3545_RS13455	COG0673	inositol 2-dehydrogenase activity
G3545_RS13485	COG3585	molybdate ion transport
G3545_RS13490	COG1720	tRNA m6t6A37 methyltransferase activity
G3545_RS13505	COG1120	ATPase activity
G3545_RS13510	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G3545_RS13515	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
G3545_RS13520	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
G3545_RS13525	COG3265	gluconokinase activity
G3545_RS13530	COG1609	Transcriptional regulator
G3545_RS13540	COG0492	ferredoxin-NADP+ reductase activity
G3545_RS13550	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G3545_RS13565	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
G3545_RS13580	COG0473	3-isopropylmalate dehydrogenase activity
G3545_RS13585	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
G3545_RS13615	COG2207	Transcriptional regulator
G3545_RS13640	COG3025	triphosphatase activity
G3545_RS13660	COG1012	belongs to the aldehyde dehydrogenase family
G3545_RS13670	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
G3545_RS13675	COG3181	Tripartite tricarboxylate transporter family receptor
G3545_RS13690	COG0523	cobalamin synthesis protein
G3545_RS13720	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
G3545_RS13735	COG3179	chitinase
G3545_RS13790	COG4974	Belongs to the 'phage' integrase family
G3545_RS13805	COG4983	Phage plasmid primase, P4 family domain protein
G3545_RS13850	COG1819	glycosyl
G3545_RS13895	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G3545_RS13900	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
G3545_RS13930	COG0625	glutathione transferase activity
G3545_RS13965	COG4191	Histidine kinase
G3545_RS13965	COG0784	Response regulator, receiver
G3545_RS13970	COG0582	viral genome integration into host DNA
G3545_RS14010	COG1196	nuclear chromosome segregation
G3545_RS14030	COG3179	chitinase
G3545_RS14210	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G3545_RS14230	COG0110	maltose O-acetyltransferase activity
G3545_RS14275	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
G3545_RS14280	COG0424	maF-like protein
G3545_RS14290	COG5328	Belongs to the UPF0262 family
G3545_RS14295	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G3545_RS14310	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G3545_RS14340	COG1732	Glycine betaine
G3545_RS14345	COG1174	glycine betaine transport
G3545_RS14350	COG1125	glycine betaine transport
G3545_RS14365	COG1174	glycine betaine transport
G3545_RS14385	COG0683	leucine binding
G3545_RS14410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G3545_RS14420	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G3545_RS14425	COG4521	taurine ABC transporter
G3545_RS14430	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
G3545_RS14435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3545_RS14445	COG1802	Transcriptional regulator
G3545_RS14475	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS14480	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
G3545_RS14485	COG2224	Isocitrate lyase
G3545_RS14495	COG3800	Transcriptional regulator
G3545_RS14495	COG1396	sequence-specific DNA binding
G3545_RS14520	COG0765	amino acid transport
G3545_RS14530	COG0405	Gamma-glutamyltransferase
G3545_RS14545	COG2376	Dihydroxyacetone kinase
G3545_RS14550	COG1172	Belongs to the binding-protein-dependent transport system permease family
G3545_RS14555	COG1129	ABC transporter
G3545_RS14570	COG1609	Transcriptional regulator
G3545_RS14580	COG0667	Aldo Keto reductase
G3545_RS14585	COG0251	oxidation-reduction process
G3545_RS14600	COG1012	belongs to the aldehyde dehydrogenase family
G3545_RS14605	COG0028	Belongs to the TPP enzyme family
G3545_RS14605	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
G3545_RS14620	COG0318	PFAM AMP-dependent synthetase and ligase
G3545_RS14625	COG0604	alcohol dehydrogenase
G3545_RS14625	COG3321	synthase
G3545_RS14625	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS14655	COG0583	DNA-binding transcription factor activity
G3545_RS14700	COG1959	2 iron, 2 sulfur cluster binding
G3545_RS14705	COG1024	Enoyl-CoA hydratase
G3545_RS14705	COG1250	3-hydroxyacyl-CoA dehydrogenase
G3545_RS14715	COG4566	intracellular signal transduction
G3545_RS14725	COG4191	Histidine kinase
G3545_RS14730	COG0656	L-ascorbic acid biosynthetic process
G3545_RS14740	COG1566	PFAM secretion protein HlyD family protein
G3545_RS14760	COG4191	Histidine kinase
G3545_RS14765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G3545_RS14765	COG1017	nitric oxide dioxygenase activity
G3545_RS14770	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
G3545_RS14775	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G3545_RS14785	COG3189	MarR family transcriptional regulator
G3545_RS14790	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS14800	COG0596	Alpha beta hydrolase
G3545_RS14805	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G3545_RS14835	COG3842	ATPase activity
G3545_RS14845	COG1176	ABC-type spermidine putrescine transport system, permease component I
G3545_RS14850	COG1177	transmembrane transport
G3545_RS14860	COG1609	Transcriptional regulator
G3545_RS14865	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G3545_RS14870	COG1304	FMN binding
G3545_RS14875	COG0582	viral genome integration into host DNA
G3545_RS14905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G3545_RS14910	COG0367	asparagine synthase
G3545_RS14920	COG3307	-O-antigen
G3545_RS14925	COG2244	polysaccharide biosynthetic process
G3545_RS14950	COG0297	glycogen (starch) synthase activity
G3545_RS14980	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G3545_RS14985	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G3545_RS15010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G3545_RS15015	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G3545_RS15025	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
G3545_RS15060	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
G3545_RS15065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3545_RS15070	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
G3545_RS15075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G3545_RS15090	COG4310	Domain of unknown function (DUF2172)
G3545_RS15100	COG0582	viral genome integration into host DNA
G3545_RS15130	COG2308	Evidence 4 Homologs of previously reported genes of
G3545_RS15130	COG2307	Protein conserved in bacteria
G3545_RS15140	COG2010	Cytochrome c
G3545_RS15140	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G3545_RS15145	COG2080	2 iron, 2 sulfur cluster binding
G3545_RS15150	COG2010	Cytochrome c
G3545_RS15150	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G3545_RS15155	COG2223	nitrite transmembrane transporter activity
G3545_RS15160	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
G3545_RS15170	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
G3545_RS15180	COG0745	RESPONSE REGULATOR receiver
G3545_RS15190	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
G3545_RS15195	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
G3545_RS15195	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G3545_RS15200	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G3545_RS15205	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
G3545_RS15255	COG3932	Exopolysaccharide synthesis, ExoD
G3545_RS15275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G3545_RS15305	COG0463	Glycosyl transferase, family 2
G3545_RS15325	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G3545_RS15360	COG0745	RESPONSE REGULATOR receiver
G3545_RS15365	COG2205	protein histidine kinase activity
G3545_RS15370	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
G3545_RS15380	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
G3545_RS15390	COG1846	Transcriptional regulator
G3545_RS15400	COG0346	lactoylglutathione lyase activity
G3545_RS15405	COG0400	carboxylic ester hydrolase activity
G3545_RS15410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G3545_RS15425	COG2321	neutral zinc metallopeptidase
G3545_RS15430	COG0521	Mo-molybdopterin cofactor biosynthetic process
G3545_RS15470	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
G3545_RS15480	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
G3545_RS15485	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
G3545_RS15495	COG1657	PFAM Prenyltransferase squalene oxidase
G3545_RS15500	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
G3545_RS15505	COG1562	ergosterol biosynthetic process
G3545_RS15510	COG1562	ergosterol biosynthetic process
G3545_RS15520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G3545_RS15545	COG1522	sequence-specific DNA binding
G3545_RS15555	COG1960	acyl-CoA dehydrogenase activity
G3545_RS15560	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G3545_RS15585	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
G3545_RS15595	COG1984	allophanate hydrolase subunit 2
G3545_RS15605	COG1802	Transcriptional regulator
G3545_RS15610	COG1178	ABC-type Fe3 transport system permease component
G3545_RS15620	COG1176	ABC-type spermidine putrescine transport system, permease component I
G3545_RS15630	COG3842	ATPase activity
G3545_RS15635	COG0459	protein refolding
G3545_RS15645	COG0439	Biotin carboxylase
G3545_RS15650	COG2204	response regulator
G3545_RS15655	COG4191	Histidine kinase
G3545_RS15660	COG1301	dicarboxylic acid transport
G3545_RS15710	COG1802	Transcriptional regulator
G3545_RS15715	COG2066	Belongs to the glutaminase family
G3545_RS15725	COG0471	metal ion transport
G3545_RS15725	COG0490	domain, Protein
G3545_RS15755	COG0450	alkyl hydroperoxide reductase
G3545_RS15760	COG3453	Protein conserved in bacteria
G3545_RS15760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G3545_RS15780	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS15785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G3545_RS15820	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
G3545_RS15825	COG1984	allophanate hydrolase subunit 2
G3545_RS15830	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
G3545_RS15835	COG3842	ATPase activity
G3545_RS15860	COG1733	regulation of RNA biosynthetic process
G3545_RS15870	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G3545_RS15875	COG2205	protein histidine kinase activity
G3545_RS15880	COG0745	RESPONSE REGULATOR receiver
G3545_RS15885	COG0583	DNA-binding transcription factor activity
G3545_RS15900	COG1733	regulation of RNA biosynthetic process
G3545_RS15920	COG0463	Glycosyl transferase, family 2
G3545_RS15930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3545_RS15935	COG1116	anion transmembrane transporter activity
G3545_RS15940	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G3545_RS15945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G3545_RS15985	COG1802	Transcriptional regulator
G3545_RS15990	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS16030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G3545_RS16040	COG2721	sulfolactate sulfo-lyase activity
G3545_RS16045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G3545_RS16050	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
G3545_RS16055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3545_RS16060	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
G3545_RS16065	COG1012	belongs to the aldehyde dehydrogenase family
G3545_RS16100	COG1607	acyl-coa hydrolase
G3545_RS16110	COG3246	L-lysine catabolic process to acetate
G3545_RS16125	COG3181	Tripartite tricarboxylate transporter family receptor
G3545_RS16140	COG1802	Transcriptional regulator
G3545_RS16145	COG0583	DNA-binding transcription factor activity
G3545_RS16175	COG2376	Dihydroxyacetone kinase
G3545_RS16210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G3545_RS16220	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G3545_RS16225	COG4221	oxidoreductase activity
G3545_RS16240	COG0765	amino acid transport
G3545_RS16245	COG0765	amino acid transport
G3545_RS16255	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G3545_RS16265	COG0800	Aldolase
G3545_RS16270	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS16285	COG2186	Transcriptional regulator
G3545_RS16290	COG4948	Mandelate Racemase Muconate Lactonizing
G3545_RS16310	COG4948	Mandelate Racemase Muconate Lactonizing
G3545_RS16325	COG0745	RESPONSE REGULATOR receiver
G3545_RS16335	COG3258	Cytochrome c
G3545_RS16355	COG0446	pyridine nucleotide-disulphide oxidoreductase
G3545_RS16365	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G3545_RS16365	COG2010	Cytochrome c
G3545_RS16385	COG2205	protein histidine kinase activity
G3545_RS16385	COG2202	Pas domain
G3545_RS16390	COG0745	RESPONSE REGULATOR receiver
G3545_RS16405	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G3545_RS16410	COG2814	Major facilitator Superfamily
G3545_RS16415	COG0667	Aldo Keto reductase
G3545_RS16425	COG0747	negative chemotaxis
G3545_RS16430	COG0601	transmembrane transport
G3545_RS16435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G3545_RS16440	COG0444	Belongs to the ABC transporter superfamily
G3545_RS16445	COG4608	Belongs to the ABC transporter superfamily
G3545_RS16460	COG1178	ABC-type Fe3 transport system permease component
G3545_RS16475	COG3842	ATPase activity
G3545_RS16485	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G3545_RS16490	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
G3545_RS16515	COG1116	anion transmembrane transporter activity
G3545_RS16520	COG0010	Belongs to the arginase family
G3545_RS16530	COG0156	8-amino-7-oxononanoate synthase activity
G3545_RS16550	COG2205	protein histidine kinase activity
G3545_RS16560	COG1970	mechanosensitive ion channel activity
G3545_RS16570	COG0432	Pfam Uncharacterised protein family UPF0047
G3545_RS16590	COG0789	Transcriptional regulator
G3545_RS16605	COG1201	RNA secondary structure unwinding
G3545_RS16610	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G3545_RS16615	COG1793	dna ligase
G3545_RS16615	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
G3545_RS16620	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
G3545_RS16620	COG1793	dna ligase
G3545_RS16635	COG0167	dihydroorotate dehydrogenase activity
G3545_RS16650	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G3545_RS16655	COG0242	peptide deformylase activity
G3545_RS16665	COG0583	DNA-binding transcription factor activity
G3545_RS16670	COG5487	UPF0391 membrane protein
G3545_RS16685	COG0784	Response regulator, receiver
G3545_RS16690	COG3920	Histidine kinase
G3545_RS16690	COG2202	Pas domain
G3545_RS16705	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
G3545_RS16710	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
G3545_RS16720	COG0574	Belongs to the PEP-utilizing enzyme family
G3545_RS16720	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G3545_RS16725	COG2259	Doxx family
G3545_RS16735	COG0751	glycine-tRNA ligase activity
G3545_RS16745	COG0752	glycyl-tRNA synthetase alpha subunit
G3545_RS16750	COG1570	exodeoxyribonuclease VII activity
G3545_RS16760	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
G3545_RS16780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G3545_RS16785	COG1309	transcriptional regulator
G3545_RS16790	COG0735	belongs to the Fur family
G3545_RS16795	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G3545_RS16805	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G3545_RS16815	COG1605	Chorismate mutase
G3545_RS16815	COG0077	Prephenate dehydratase
G3545_RS16820	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
G3545_RS16825	COG3474	cytochrome
G3545_RS16830	COG4166	transmembrane transport
G3545_RS16840	COG4174	ABC transporter (Permease)
G3545_RS16845	COG4239	(ABC) transporter, permease
G3545_RS16850	COG4172	Belongs to the ABC transporter superfamily
G3545_RS16860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G3545_RS16865	COG0791	NLP P60 protein
G3545_RS16875	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G3545_RS16895	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G3545_RS16900	COG0484	heat shock protein binding
G3545_RS16910	COG0259	pyridoxamine-phosphate oxidase activity
G3545_RS16915	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS16940	COG1376	ErfK ybiS ycfS ynhG family protein
G3545_RS16945	COG1408	metallophosphoesterase
G3545_RS16950	COG1408	metallophosphoesterase
G3545_RS16980	COG0288	reversible hydration of carbon dioxide
G3545_RS17005	COG4459	periplasmic nitrate reductase
G3545_RS17015	COG3062	negative regulation of establishment of protein localization
G3545_RS17020	COG0243	molybdopterin cofactor binding
G3545_RS17025	COG3043	anaerobic respiration
G3545_RS17030	COG3005	denitrification pathway
G3545_RS17045	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G3545_RS17055	COG0346	lactoylglutathione lyase activity
G3545_RS17070	COG1074	ATP-dependent DNA helicase activity
G3545_RS17075	COG2887	Belongs to the helicase family. UvrD subfamily
G3545_RS17080	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
G3545_RS17085	COG3178	'Phosphotransferase
G3545_RS17090	COG2205	protein histidine kinase activity
G3545_RS17100	COG1959	2 iron, 2 sulfur cluster binding
G3545_RS17105	COG0756	dUTP diphosphatase activity
G3545_RS17110	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G3545_RS17115	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G3545_RS17120	COG2226	methyltransferase
G3545_RS17130	COG1376	ErfK ybiS ycfS ynhG family protein
G3545_RS17160	COG1137	ATPase activity
G3545_RS17180	COG3300	MHYT domain
G3545_RS17180	COG5001	Diguanylate cyclase
G3545_RS17190	COG0840	transmembrane signaling receptor activity
G3545_RS17210	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G3545_RS17225	COG0625	glutathione transferase activity
G3545_RS17230	COG2189	Belongs to the N(4) N(6)-methyltransferase family
G3545_RS17240	COG1196	nuclear chromosome segregation
G3545_RS17245	COG2084	Dehydrogenase
G3545_RS17265	COG0356	it plays a direct role in the translocation of protons across the membrane
G3545_RS17270	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G3545_RS17275	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
G3545_RS17280	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
G3545_RS17290	COG0009	L-threonylcarbamoyladenylate synthase
G3545_RS17295	COG0123	including yeast histone deacetylase and acetoin utilization protein
G3545_RS17300	COG1722	exodeoxyribonuclease VII activity
G3545_RS17310	COG3813	Protein conserved in bacteria
G3545_RS17325	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
G3545_RS17345	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G3545_RS17355	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G3545_RS17355	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G3545_RS17360	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
G3545_RS17365	COG1253	flavin adenine dinucleotide binding
G3545_RS17375	COG1459	type II secretion system
G3545_RS17395	COG4964	Belongs to the GSP D family
G3545_RS17440	COG1643	Atp-dependent helicase
G3545_RS17465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G3545_RS17470	COG0124	histidyl-tRNA synthetase
G3545_RS17475	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
G3545_RS17480	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
G3545_RS17485	COG1648	precorrin-2 dehydrogenase activity
G3545_RS17485	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G3545_RS17495	COG2862	Uncharacterized protein family, UPF0114
G3545_RS17500	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G3545_RS17510	COG0204	Acyl-transferase
G3545_RS17510	COG0318	PFAM AMP-dependent synthetase and ligase
G3545_RS17525	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
G3545_RS17530	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
G3545_RS17545	COG2816	NAD+ diphosphatase activity
G3545_RS17560	COG0717	Belongs to the dCTP deaminase family
G3545_RS17570	COG2967	ApaG domain
G3545_RS17575	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
G3545_RS17590	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G3545_RS17595	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G3545_RS17605	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
G3545_RS17615	COG2059	Chromate
G3545_RS17620	COG2059	Chromate
G3545_RS17625	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
G3545_RS17650	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G3545_RS17665	COG2171	N-acyltransferase activity
G3545_RS17670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G3545_RS17715	COG3454	Phosphonate metabolism
G3545_RS17720	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
G3545_RS17730	COG0616	signal peptide processing
G3545_RS17735	COG0776	regulation of translation
G3545_RS17745	COG2423	ornithine cyclodeaminase activity
G3545_RS17750	COG4208	sulfate ABC transporter
G3545_RS17760	COG4150	thiosulfate binding
G3545_RS17765	COG0174	glutamine synthetase
G3545_RS17775	COG2066	Belongs to the glutaminase family
G3545_RS17785	COG0135	phosphoribosylanthranilate isomerase activity
G3545_RS17790	COG0133	tryptophan synthase activity
G3545_RS17795	COG0159	tryptophan synthase activity
G3545_RS17800	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
G3545_RS17815	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G3545_RS17830	COG0742	ribosomal rna small subunit methyltransferase
G3545_RS17840	COG0590	tRNA wobble adenosine to inosine editing
G3545_RS17850	COG0151	Belongs to the GarS family
G3545_RS17855	COG1136	(ABC) transporter
G3545_RS17855	COG0577	efflux transmembrane transporter activity
G3545_RS17860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3545_RS17885	COG0142	geranyltranstransferase activity
G3545_RS17890	COG1742	UPF0060 membrane protein
G3545_RS17895	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
G3545_RS17900	COG0779	Required for maturation of 30S ribosomal subunits
G3545_RS17915	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
G3545_RS17925	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G3545_RS17930	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
G3545_RS17935	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
G3545_RS17940	COG1185	polyribonucleotide nucleotidyltransferase activity
G3545_RS17950	COG0252	asparaginase activity
G3545_RS17955	COG0247	lactate metabolic process
G3545_RS17960	COG0277	FAD linked oxidase domain protein
G3545_RS17975	COG0277	FAD linked oxidase domain protein
G3545_RS17990	COG1595	DNA-templated transcription, initiation
G3545_RS18020	COG0612	Peptidase, M16
G3545_RS18025	COG0612	Peptidase, M16
G3545_RS18035	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
G3545_RS18040	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G3545_RS18045	COG0196	riboflavin kinase activity
G3545_RS18055	COG1764	response to oxidative stress
G3545_RS18060	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G3545_RS18060	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G3545_RS18070	COG0101	tRNA pseudouridine synthase activity
G3545_RS18075	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G3545_RS18080	COG0354	folic acid binding
G3545_RS18085	COG0519	Catalyzes the synthesis of GMP from XMP
G3545_RS18090	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
G3545_RS18100	COG2010	Cytochrome c
G3545_RS18100	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G3545_RS18105	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS18110	COG0583	DNA-binding transcription factor activity
G3545_RS18125	COG2259	Doxx family
G3545_RS18150	COG0220	tRNA (guanine-N7-)-methyltransferase activity
G3545_RS18155	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G3545_RS18160	COG1396	sequence-specific DNA binding
G3545_RS18165	COG0815	Transfers the fatty acyl group on membrane lipoproteins
G3545_RS18170	COG1253	flavin adenine dinucleotide binding
G3545_RS18175	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
G3545_RS18180	COG1702	phosphate starvation-inducible protein PhoH
G3545_RS18185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G3545_RS18210	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
G3545_RS18225	COG0180	Tryptophanyl-tRNA synthetase
G3545_RS18235	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G3545_RS18270	COG0745	RESPONSE REGULATOR receiver
G3545_RS18275	COG0704	Plays a role in the regulation of phosphate uptake
G3545_RS18280	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G3545_RS18290	COG0573	inorganic phosphate transmembrane transporter activity
G3545_RS18295	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G3545_RS18300	COG5002	protein histidine kinase activity
G3545_RS18305	COG2326	polyphosphate kinase activity
G3545_RS18320	COG3158	transport of potassium into the cell
G3545_RS18340	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
G3545_RS18355	COG0443	Heat shock 70 kDa protein
G3545_RS18360	COG0484	heat shock protein binding
G3545_RS18365	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G3545_RS18370	COG0431	NADPH-dependent FMN reductase
G3545_RS18385	COG0828	Belongs to the bacterial ribosomal protein bS21 family
G3545_RS18390	COG2261	transglycosylase associated protein
G3545_RS18425	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
G3545_RS18430	COG0539	negative regulation of cytoplasmic translation
G3545_RS18445	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
G3545_RS18450	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G3545_RS18480	COG0154	amidase activity
G3545_RS18495	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G3545_RS18500	COG2271	Major facilitator Superfamily
G3545_RS18510	COG0306	phosphate transporter
G3545_RS18515	COG1252	NADH dehydrogenase
G3545_RS18520	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G3545_RS18520	COG0475	glutathione-regulated potassium exporter activity
G3545_RS18530	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
G3545_RS18535	COG3383	formate dehydrogenase (NAD+) activity
G3545_RS18550	COG0606	chelatase, subunit chli
G3545_RS18560	COG0071	Belongs to the small heat shock protein (HSP20) family
G3545_RS18570	COG0189	ligase activity
G3545_RS18575	COG0792	nuclease activity
G3545_RS18580	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
G3545_RS18590	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G3545_RS18595	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
G3545_RS18600	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
G3545_RS18605	COG1733	regulation of RNA biosynthetic process
G3545_RS18620	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G3545_RS18635	COG1072	(Pantothenic acid kinase))
G3545_RS18640	COG0140	phosphoribosyl-ATP diphosphatase activity
G3545_RS18645	COG0107	imidazoleglycerol-phosphate synthase activity
G3545_RS18650	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
G3545_RS18655	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
G3545_RS18665	COG0131	Imidazoleglycerol-phosphate dehydratase
G3545_RS18675	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
G3545_RS18685	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
G3545_RS18695	COG3609	addiction module antidote protein, CC2985 family
G3545_RS18700	COG1396	sequence-specific DNA binding
G3545_RS18720	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
G3545_RS18725	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G3545_RS18730	COG0237	dephospho-CoA kinase activity
G3545_RS18735	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G3545_RS18740	COG0424	maF-like protein
G3545_RS18745	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
G3545_RS18750	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
G3545_RS18760	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
G3545_RS18775	COG1331	Highly conserved protein containing a thioredoxin domain
G3545_RS18785	COG0445	tRNA wobble uridine modification
G3545_RS18790	COG0357	Ribosomal RNA small subunit methyltransferase G
G3545_RS18815	COG0495	leucyl-tRNA aminoacylation
G3545_RS18820	COG5001	Diguanylate cyclase
G3545_RS18820	COG4251	negative regulation of phosphorylation
G3545_RS18820	COG3706	GGDEF domain
G3545_RS18820	COG2203	Gaf domain
G3545_RS18840	COG0745	RESPONSE REGULATOR receiver
G3545_RS18845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G3545_RS18855	COG0129	dihydroxy-acid dehydratase activity
G3545_RS18860	COG0363	glucosamine-6-phosphate deaminase activity
G3545_RS18865	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
G3545_RS18885	COG1802	Transcriptional regulator
G3545_RS18895	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
G3545_RS18900	COG5001	Diguanylate cyclase
G3545_RS18900	COG3300	MHYT domain
G3545_RS18915	COG1450	Type ii and iii secretion system protein
G3545_RS18935	COG4789	Type iii secretion
G3545_RS19015	COG4669	(LipO)protein
G3545_RS19050	COG4790	Type iii secretion
G3545_RS19055	COG4794	Type iii secretion
G3545_RS19060	COG4791	protein targeting
G3545_RS19065	COG4792	protein secretion
G3545_RS19120	COG0402	S-adenosylhomocysteine deaminase activity
G3545_RS19125	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G3545_RS19125	COG2080	2 iron, 2 sulfur cluster binding
G3545_RS19145	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS19160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G3545_RS19185	COG2144	transferase activity, transferring acyl groups
G3545_RS19190	COG0438	transferase activity, transferring glycosyl groups
G3545_RS19200	COG2072	flavoprotein involved in K transport
G3545_RS19215	COG4957	zinc ion binding
G3545_RS19235	COG1695	Transcriptional regulator
G3545_RS19240	COG2079	MmgE PrpD family protein
G3545_RS19245	COG0473	3-isopropylmalate dehydrogenase activity
G3545_RS19255	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G3545_RS19260	COG2186	Transcriptional regulator
G3545_RS19270	COG0473	3-isopropylmalate dehydrogenase activity
G3545_RS19300	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
G3545_RS19310	COG0596	Alpha beta hydrolase
G3545_RS19315	COG0583	DNA-binding transcription factor activity
G3545_RS19320	COG2855	membrane
G3545_RS19340	COG0500	methyltransferase
G3545_RS19345	COG3239	Fatty acid desaturase
G3545_RS19350	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
G3545_RS19355	COG0459	protein refolding
G3545_RS19390	COG2271	Major facilitator Superfamily
G3545_RS19405	COG3618	amidohydrolase
G3545_RS19435	COG0697	spore germination
G3545_RS19450	COG2814	Major facilitator Superfamily
G3545_RS19455	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
G3545_RS19460	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G3545_RS19465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3545_RS19485	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G3545_RS19490	COG0473	3-isopropylmalate dehydrogenase activity
G3545_RS19495	COG4172	Belongs to the ABC transporter superfamily
G3545_RS19510	COG0747	negative chemotaxis
G3545_RS19515	COG0747	negative chemotaxis
G3545_RS19535	COG0583	DNA-binding transcription factor activity
G3545_RS19550	COG3842	ATPase activity
G3545_RS19555	COG1178	ABC-type Fe3 transport system permease component
G3545_RS19560	COG0179	Fumarylacetoacetate (FAA) hydrolase
G3545_RS19565	COG2186	Transcriptional regulator
G3545_RS19575	COG0477	Major facilitator Superfamily
G3545_RS19585	COG0402	S-adenosylhomocysteine deaminase activity
G3545_RS19590	COG3842	ATPase activity
G3545_RS19595	COG1177	transmembrane transport
G3545_RS19610	COG0590	tRNA wobble adenosine to inosine editing
G3545_RS19615	COG0154	amidase activity
G3545_RS19620	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
G3545_RS19625	COG0583	DNA-binding transcription factor activity
G3545_RS19635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G3545_RS19640	COG0745	RESPONSE REGULATOR receiver
G3545_RS19645	COG4566	intracellular signal transduction
G3545_RS19650	COG4191	Histidine kinase
G3545_RS19665	COG3938	Belongs to the proline racemase family
G3545_RS19670	COG4948	Mandelate Racemase Muconate Lactonizing
G3545_RS19675	COG3938	Belongs to the proline racemase family
G3545_RS19680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3545_RS19685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G3545_RS19710	COG1802	Transcriptional regulator
G3545_RS19735	COG0443	Heat shock 70 kDa protein
G3545_RS19755	COG4948	Mandelate Racemase Muconate Lactonizing
G3545_RS19765	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
G3545_RS19775	COG1131	(ABC) transporter
G3545_RS19805	COG2814	Major facilitator Superfamily
G3545_RS19815	COG0463	Glycosyl transferase, family 2
G3545_RS19830	COG0745	RESPONSE REGULATOR receiver
G3545_RS19885	COG0431	NADPH-dependent FMN reductase
G3545_RS19890	COG3795	YCII-related domain
G3545_RS19950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G3545_RS19960	COG0628	permease
G3545_RS19975	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS19985	COG0583	DNA-binding transcription factor activity
G3545_RS19990	COG0179	Fumarylacetoacetate (FAA) hydrolase
G3545_RS19995	COG1082	Xylose isomerase domain protein TIM barrel
G3545_RS20050	COG0587	DNA-directed DNA polymerase activity
G3545_RS20055	COG1177	transmembrane transport
G3545_RS20065	COG3842	ATPase activity
G3545_RS20070	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
G3545_RS20080	COG0842	Transport permease protein
G3545_RS20085	COG1131	(ABC) transporter
G3545_RS20090	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
G3545_RS20095	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G3545_RS20105	COG0211	Belongs to the bacterial ribosomal protein bL27 family
G3545_RS20110	COG0261	This protein binds to 23S rRNA in the presence of protein L20
G3545_RS20130	COG2368	4-hydroxyphenylacetate
G3545_RS20145	COG0583	DNA-binding transcription factor activity
G3545_RS20150	COG0196	riboflavin kinase activity
G3545_RS20155	COG1027	Aspartate ammonia-lyase
G3545_RS20160	COG3842	ATPase activity
G3545_RS20170	COG1176	ABC-type spermidine putrescine transport system, permease component I
G3545_RS20175	COG1176	ABC-type spermidine putrescine transport system, permease component I
G3545_RS20185	COG0633	Ferredoxin
G3545_RS20190	COG4638	Rieske (2fe-2S)
G3545_RS20195	COG4638	Rieske (2fe-2S)
G3545_RS20235	COG1505	serine-type exopeptidase activity
G3545_RS20240	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G3545_RS20250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G3545_RS20255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G3545_RS20265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G3545_RS20275	COG1819	glycosyl
G3545_RS20295	COG1574	metal-dependent hydrolase with the TIM-barrel fold
G3545_RS20300	COG3842	ATPase activity
G3545_RS20305	COG1176	ABC-type spermidine putrescine transport system, permease component I
G3545_RS20310	COG1177	transmembrane transport
G3545_RS20340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3545_RS20350	COG1522	sequence-specific DNA binding
G3545_RS20355	COG0778	Nitroreductase
G3545_RS20365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G3545_RS20380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G3545_RS20385	COG1917	Cupin 2, conserved barrel domain protein
G3545_RS20390	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
G3545_RS20415	COG0583	DNA-binding transcription factor activity
G3545_RS20420	COG0247	lactate metabolic process
G3545_RS20440	COG0300	oxidoreductase activity
G3545_RS20445	COG0583	DNA-binding transcription factor activity
G3545_RS20460	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G3545_RS20460	COG2010	Cytochrome c
G3545_RS20470	COG0596	Alpha beta hydrolase
G3545_RS20505	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
G3545_RS20510	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS20515	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G3545_RS20520	COG1063	alcohol dehydrogenase
G3545_RS20560	COG1132	(ABC) transporter
G3545_RS20565	COG1349	DNA-binding transcription factor activity
G3545_RS20570	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G3545_RS20575	COG3395	kinase activity
G3545_RS20590	COG1942	4-Oxalocrotonate Tautomerase
G3545_RS20595	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS20600	COG0583	DNA-binding transcription factor activity
G3545_RS20605	COG2329	Antibiotic biosynthesis monooxygenase
G3545_RS20610	COG4771	TonB-dependent receptor
G3545_RS20620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G3545_RS20625	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
G3545_RS20635	COG0534	Mate efflux family protein
G3545_RS20640	COG3706	GGDEF domain
G3545_RS20645	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G3545_RS20650	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G3545_RS20725	COG4106	trans-aconitate 2-methyltransferase activity
G3545_RS20730	COG4948	Mandelate Racemase Muconate Lactonizing
G3545_RS20740	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
G3545_RS20760	COG2059	Chromate
G3545_RS20785	COG1802	Transcriptional regulator
G3545_RS20800	COG3181	Tripartite tricarboxylate transporter family receptor
G3545_RS20820	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS20830	COG3842	ATPase activity
G3545_RS20835	COG1177	transmembrane transport
G3545_RS20845	COG1349	DNA-binding transcription factor activity
G3545_RS20850	COG2267	carboxylic ester hydrolase activity
G3545_RS20855	COG1335	isochorismatase
G3545_RS20880	COG4206	TonB-dependent receptor
G3545_RS20880	COG1629	transport
G3545_RS20890	COG1595	DNA-templated transcription, initiation
G3545_RS20895	COG0477	Major facilitator Superfamily
G3545_RS20905	COG1595	DNA-templated transcription, initiation
G3545_RS20930	COG4221	oxidoreductase activity
G3545_RS20960	COG3220	belongs to the UPF0276 family
G3545_RS20975	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G3545_RS20985	COG1132	(ABC) transporter
G3545_RS21005	COG0747	negative chemotaxis
G3545_RS21010	COG0601	transmembrane transport
G3545_RS21015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G3545_RS21030	COG0438	transferase activity, transferring glycosyl groups
G3545_RS21035	COG0438	transferase activity, transferring glycosyl groups
G3545_RS21050	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
G3545_RS21055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G3545_RS21060	COG0552	protein localization to endoplasmic reticulum
G3545_RS21065	COG2917	probably involved in intracellular septation
G3545_RS21070	COG0667	Aldo Keto reductase
G3545_RS21080	COG4181	ATPase activity
G3545_RS21090	COG0670	Belongs to the BI1 family
G3545_RS21100	COG0517	IMP dehydrogenase activity
G3545_RS21100	COG1994	Peptidase M50
G3545_RS21110	COG0137	argininosuccinate synthase activity
G3545_RS21115	COG0671	phosphoesterase, PA-phosphatase related
G3545_RS21125	COG0820	rRNA (adenine-C2-)-methyltransferase activity
G3545_RS21155	COG0789	Transcriptional regulator
G3545_RS21165	COG0165	Argininosuccinate lyase
G3545_RS21170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G3545_RS21175	COG0697	spore germination
G3545_RS21185	COG1250	3-hydroxyacyl-CoA dehydrogenase
G3545_RS21190	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
G3545_RS21195	COG2086	electron transfer activity
G3545_RS21215	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
G3545_RS21230	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
G3545_RS21240	COG0799	negative regulation of ribosome biogenesis
G3545_RS21245	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
G3545_RS21255	COG0793	Belongs to the peptidase S41A family
G3545_RS21265	COG0494	nUDIX hydrolase
G3545_RS21270	COG1309	transcriptional regulator
G3545_RS21285	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G3545_RS21290	COG3118	belongs to the thioredoxin family
G3545_RS21305	COG1802	Transcriptional regulator
G3545_RS21310	COG2835	tetraacyldisaccharide 4'-kinase activity
G3545_RS21315	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G3545_RS21320	COG1946	Acyl-CoA thioesterase
G3545_RS21325	COG0347	Belongs to the P(II) protein family
G3545_RS21330	COG0004	ammonium transporteR
G3545_RS21335	COG0436	Aminotransferase
G3545_RS21340	COG1674	ftsk spoiiie
G3545_RS21360	COG0019	diaminopimelate decarboxylase activity
G3545_RS21375	COG2884	Cell division ATP-binding protein ftsE
G3545_RS21395	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
G3545_RS21405	COG0287	Prephenate dehydrogenase
G3545_RS21410	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G3545_RS21420	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G3545_RS21425	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G3545_RS21425	COG2813	Specifically methylates the guanine in position
G3545_RS21440	COG0513	Belongs to the DEAD box helicase family
G3545_RS21445	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G3545_RS21455	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
G3545_RS21455	COG0352	thiamine-phosphate diphosphorylase activity
G3545_RS21455	COG0351	phosphomethylpyrimidine kinase
G3545_RS21460	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G3545_RS21465	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G3545_RS21470	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
G3545_RS21475	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G3545_RS21480	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G3545_RS21485	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G3545_RS21490	COG4133	protoheme IX ABC transporter activity
G3545_RS21495	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
G3545_RS21515	COG0583	DNA-binding transcription factor activity
G3545_RS21520	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS21535	COG1063	alcohol dehydrogenase
G3545_RS21540	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS21555	COG1175	transmembrane transport
G3545_RS21565	COG4977	sequence-specific DNA binding
G3545_RS21610	COG0235	Class ii aldolase
G3545_RS21635	COG0154	amidase activity
G3545_RS21640	COG0418	dihydroorotase activity
G3545_RS21650	COG0604	alcohol dehydrogenase
G3545_RS21650	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS21650	COG3321	synthase
G3545_RS21660	COG0318	PFAM AMP-dependent synthetase and ligase
G3545_RS21675	COG0163	prenyltransferase activity
G3545_RS21695	COG1802	Transcriptional regulator
G3545_RS21715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3545_RS21725	COG0745	RESPONSE REGULATOR receiver
G3545_RS21730	COG2205	protein histidine kinase activity
G3545_RS21745	COG1309	transcriptional regulator
G3545_RS21750	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS21770	COG0583	DNA-binding transcription factor activity
G3545_RS21775	COG1454	alcohol dehydrogenase
G3545_RS21780	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G3545_RS21825	COG1609	Transcriptional regulator
G3545_RS21830	COG3842	ATPase activity
G3545_RS21835	COG4208	sulfate ABC transporter
G3545_RS21840	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G3545_RS21845	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G3545_RS21850	COG1840	ABC-type Fe3 transport system, periplasmic component
G3545_RS21855	COG1304	FMN binding
G3545_RS21875	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS21880	COG0179	Fumarylacetoacetate (FAA) hydrolase
G3545_RS21885	COG3875	lactate racemase activity
G3545_RS21900	COG1691	(AIR) carboxylase
G3545_RS21920	COG1176	ABC-type spermidine putrescine transport system, permease component I
G3545_RS21925	COG3842	ATPase activity
G3545_RS21935	COG1802	Transcriptional regulator
G3545_RS21960	COG1024	Enoyl-CoA hydratase
G3545_RS21970	COG0501	Belongs to the peptidase M48B family
G3545_RS22075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3545_RS22095	COG1414	Transcriptional regulator
G3545_RS22100	COG0583	DNA-binding transcription factor activity
G3545_RS22105	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G3545_RS22110	COG0066	3-isopropylmalate dehydratase activity
G3545_RS22135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3545_RS22140	COG1609	Transcriptional regulator
G3545_RS22145	COG3395	kinase activity
G3545_RS22150	COG0235	Class ii aldolase
G3545_RS22155	COG2084	Dehydrogenase
G3545_RS22165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G3545_RS22170	COG0747	negative chemotaxis
G3545_RS22175	COG0601	transmembrane transport
G3545_RS22185	COG4172	Belongs to the ABC transporter superfamily
G3545_RS22190	COG1609	Transcriptional regulator
G3545_RS22195	COG1053	succinate dehydrogenase
G3545_RS22220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G3545_RS22235	COG4209	transmembrane transport
G3545_RS22240	COG0395	ABC-type sugar transport system, permease component
G3545_RS22250	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS22255	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G3545_RS22275	COG3842	ATPase activity
G3545_RS22290	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G3545_RS22295	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS22310	COG0784	Response regulator, receiver
G3545_RS22310	COG4191	Histidine kinase
G3545_RS22315	COG4178	(ABC) transporter
G3545_RS22340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G3545_RS22345	COG0765	amino acid transport
G3545_RS22350	COG0765	amino acid transport
G3545_RS22375	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
G3545_RS22390	COG1247	-acetyltransferase
G3545_RS22395	COG1872	DUF167
G3545_RS22470	COG0110	maltose O-acetyltransferase activity
G3545_RS22510	COG4251	negative regulation of phosphorylation
G3545_RS22520	COG0366	Alpha amylase catalytic
G3545_RS22565	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G3545_RS22570	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
G3545_RS22580	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
G3545_RS22590	COG0400	carboxylic ester hydrolase activity
G3545_RS22595	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
G3545_RS22600	COG0739	heme binding
G3545_RS22615	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
G3545_RS22620	COG1053	succinate dehydrogenase
G3545_RS22630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G3545_RS22660	COG4974	Belongs to the 'phage' integrase family
G3545_RS22670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G3545_RS22675	COG1620	l-lactate permease
G3545_RS22680	COG0508	dehydrogenase complex catalyzes the overall conversion of
G3545_RS22685	COG0567	Dehydrogenase, E1 component
G3545_RS22690	COG0039	L-malate dehydrogenase activity
G3545_RS22700	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
G3545_RS22720	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
G3545_RS22720	COG3264	Mechanosensitive ion channel
G3545_RS22740	COG0523	cobalamin synthesis protein
G3545_RS22745	COG1686	Belongs to the peptidase S11 family
G3545_RS22750	COG1132	(ABC) transporter
G3545_RS22755	COG0140	phosphoribosyl-ATP diphosphatase activity
G3545_RS22760	COG1238	metal cluster binding
G3545_RS22765	COG4208	sulfate ABC transporter
G3545_RS22770	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
G3545_RS22780	COG0175	sulfate reduction
G3545_RS22790	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G3545_RS22815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3545_RS22890	COG0583	DNA-binding transcription factor activity
G3545_RS22905	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
G3545_RS22910	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
G3545_RS22915	COG0747	negative chemotaxis
G3545_RS22920	COG0601	transmembrane transport
G3545_RS22925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G3545_RS22930	COG0444	Belongs to the ABC transporter superfamily
G3545_RS22935	COG4608	Belongs to the ABC transporter superfamily
G3545_RS22940	COG0583	DNA-binding transcription factor activity
G3545_RS22965	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
G3545_RS22970	COG1879	ABC-type sugar transport system periplasmic component
G3545_RS22975	COG1129	ABC transporter
G3545_RS22980	COG1172	Belongs to the binding-protein-dependent transport system permease family
G3545_RS22985	COG1172	Belongs to the binding-protein-dependent transport system permease family
G3545_RS23010	COG0129	dihydroxy-acid dehydratase activity
G3545_RS23015	COG3386	PFAM SMP-30 Gluconolaconase
G3545_RS23020	COG3734	2-keto-3-deoxy-galactonokinase
G3545_RS23025	COG0800	Aldolase
G3545_RS23030	COG4213	ABC transporter substrate-binding protein
G3545_RS23040	COG4214	carbohydrate transport
G3545_RS23055	COG1129	ABC transporter
G3545_RS23065	COG1879	ABC-type sugar transport system periplasmic component
G3545_RS23075	COG1129	ABC transporter
G3545_RS23080	COG1172	Belongs to the binding-protein-dependent transport system permease family
G3545_RS23085	COG0673	inositol 2-dehydrogenase activity
G3545_RS23095	COG2186	Transcriptional regulator
G3545_RS23100	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
G3545_RS23105	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
G3545_RS23110	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G3545_RS23115	COG0287	Prephenate dehydrogenase
G3545_RS23125	COG1850	ribulose-bisphosphate carboxylase activity
G3545_RS23130	COG2423	ornithine cyclodeaminase activity
G3545_RS23135	COG0010	Belongs to the arginase family
G3545_RS23160	COG1473	amidohydrolase
G3545_RS23170	COG1942	4-Oxalocrotonate Tautomerase
G3545_RS23175	COG0300	oxidoreductase activity
G3545_RS23205	COG1802	Transcriptional regulator
G3545_RS23215	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS23230	COG3938	Belongs to the proline racemase family
G3545_RS23250	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G3545_RS23255	COG3938	Belongs to the proline racemase family
G3545_RS23260	COG2766	serine protein kinase
G3545_RS23265	COG2718	Belongs to the UPF0229 family
G3545_RS23270	COG2719	SpoVR family
G3545_RS23290	COG1595	DNA-templated transcription, initiation
G3545_RS23300	COG1177	transmembrane transport
G3545_RS23305	COG3842	ATPase activity
G3545_RS23315	COG3284	Transcriptional regulator
G3545_RS23335	COG0277	FAD linked oxidase domain protein
G3545_RS23345	COG1177	transmembrane transport
G3545_RS23355	COG3842	ATPase activity
G3545_RS23360	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
G3545_RS23375	COG3618	amidohydrolase
G3545_RS23385	COG4154	Belongs to the RbsD FucU family
G3545_RS23395	COG2721	sulfolactate sulfo-lyase activity
G3545_RS23400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G3545_RS23405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3545_RS23420	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
G3545_RS23440	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G3545_RS23445	COG4948	Mandelate Racemase Muconate Lactonizing
G3545_RS23450	COG3193	protein, possibly involved in utilization of glycolate and propanediol
G3545_RS23470	COG2368	4-hydroxyphenylacetate
G3545_RS23475	COG0583	DNA-binding transcription factor activity
G3545_RS23480	COG1937	Protein conserved in bacteria
G3545_RS23500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G3545_RS23510	COG1176	ABC-type spermidine putrescine transport system, permease component I
G3545_RS23515	COG1177	transmembrane transport
G3545_RS23520	COG3842	ATPase activity
G3545_RS23525	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
G3545_RS23555	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
G3545_RS23580	COG3166	PFAM Fimbrial assembly family protein
G3545_RS23615	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G3545_RS23620	COG1450	Type ii and iii secretion system protein
G3545_RS23640	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G3545_RS23645	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G3545_RS23650	COG1845	cytochrome c oxidase, subunit III
G3545_RS23655	COG1845	cytochrome c oxidase, subunit III
G3545_RS23665	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G3545_RS23675	COG1464	Belongs to the NlpA lipoprotein family
G3545_RS23680	COG2011	ABC-type metal ion transport system permease component
G3545_RS23685	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G3545_RS23695	COG1464	Belongs to the NlpA lipoprotein family
G3545_RS23720	COG0789	Transcriptional regulator
G3545_RS23725	COG0300	oxidoreductase activity
G3545_RS23730	COG0583	DNA-binding transcription factor activity
G3545_RS23735	COG2814	Major facilitator Superfamily
G3545_RS23755	COG3842	ATPase activity
G3545_RS23765	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G3545_RS23785	COG1737	Transcriptional regulator
G3545_RS23790	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G3545_RS23795	COG0022	dehydrogenase e1 component
G3545_RS23805	COG3199	ATP-NAD kinase
G3545_RS23810	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G3545_RS23815	COG0022	dehydrogenase e1 component
G3545_RS23820	COG0508	dehydrogenase complex catalyzes the overall conversion of
G3545_RS23820	COG0596	Alpha beta hydrolase
G3545_RS23835	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
G3545_RS23850	COG3023	N-Acetylmuramoyl-L-alanine amidase
G3545_RS23855	COG2001	Belongs to the MraZ family
G3545_RS23860	COG0275	rRNA processing
G3545_RS23875	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G3545_RS23880	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G3545_RS23885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G3545_RS23895	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
G3545_RS23910	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G3545_RS23915	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G3545_RS23925	COG2361	Protein of unknown function DUF86
G3545_RS23930	COG0812	UDP-N-acetylmuramate dehydrogenase activity
G3545_RS23935	COG1181	Belongs to the D-alanine--D-alanine ligase family
G3545_RS23940	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G3545_RS23945	COG0849	cell division
G3545_RS23950	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
G3545_RS23960	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G3545_RS23965	COG0497	DNA recombination
G3545_RS23970	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G3545_RS23980	COG0006	proline dipeptidase activity
G3545_RS23990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G3545_RS23995	COG0210	DNA helicase
G3545_RS24000	COG2264	protein methyltransferase activity
G3545_RS24015	COG0277	FAD linked oxidase domain protein
G3545_RS24025	COG0560	Phosphoserine phosphatase
G3545_RS24030	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G3545_RS24040	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
G3545_RS24055	COG2989	Protein conserved in bacteria
G3545_RS24060	COG1283	sodium-dependent phosphate transmembrane transporter activity
G3545_RS24070	COG3750	Belongs to the UPF0335 family
G3545_RS24110	COG0330	HflC and HflK could
G3545_RS24125	COG0114	fumarate hydratase activity
G3545_RS24175	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G3545_RS24180	COG0328	RNA-DNA hybrid ribonuclease activity
G3545_RS24185	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
G3545_RS24190	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
G3545_RS24215	COG0678	peroxiredoxin activity
G3545_RS24225	COG1678	Uncharacterized ACR, COG1678
G3545_RS24250	COG3588	fructose-bisphosphate aldolase
G3545_RS24255	COG0126	phosphoglycerate kinase activity
G3545_RS24290	COG2814	Major facilitator Superfamily
G3545_RS24295	COG0483	inositol monophosphate 1-phosphatase activity
G3545_RS24305	COG1360	Flagellar Motor Protein
G3545_RS24320	COG1132	(ABC) transporter
G3545_RS24325	COG0254	rRNA binding
G3545_RS24330	COG1692	metallophosphoesterase
G3545_RS24345	COG0604	alcohol dehydrogenase
G3545_RS24360	COG0217	transcriptional regulatory protein
G3545_RS24395	COG0659	secondary active sulfate transmembrane transporter activity
G3545_RS24400	COG0446	pyridine nucleotide-disulphide oxidoreductase
G3545_RS24400	COG1902	pentaerythritol trinitrate reductase activity
G3545_RS24405	COG2181	nitrate reductase activity
G3545_RS24405	COG0247	lactate metabolic process
G3545_RS24425	COG1012	belongs to the aldehyde dehydrogenase family
G3545_RS24435	COG4176	ABC-type proline glycine betaine transport system permease component
G3545_RS24440	COG4175	Glycine betaine
G3545_RS24440	COG3448	diguanylate cyclase activity
G3545_RS24445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G3545_RS24455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G3545_RS24460	COG0037	tRNA processing
G3545_RS24470	COG2885	chlorophyll binding
G3545_RS24475	COG0823	Involved in the tonB-independent uptake of proteins
G3545_RS24490	COG0811	peptide transport
G3545_RS24495	COG0824	Thioesterase
G3545_RS24515	COG0632	four-way junction helicase activity
G3545_RS24525	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
G3545_RS24530	COG0667	Aldo Keto reductase
G3545_RS24535	COG0583	DNA-binding transcription factor activity
G3545_RS24545	COG1760	l-serine dehydratase
G3545_RS24555	COG0446	pyridine nucleotide-disulphide oxidoreductase
G3545_RS24555	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G3545_RS24595	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G3545_RS24600	COG0800	Aldolase
G3545_RS24635	COG2514	catechol 2,3-dioxygenase activity
G3545_RS24640	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G3545_RS24655	COG0045	succinate-CoA ligase (ADP-forming) activity
G3545_RS24665	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
G3545_RS24670	COG2084	Dehydrogenase
G3545_RS24675	COG3622	Belongs to the hyi family
G3545_RS24680	COG3960	tartronate-semialdehyde synthase activity
G3545_RS24700	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G3545_RS24710	COG1802	Transcriptional regulator
G3545_RS24720	COG1802	Transcriptional regulator
G3545_RS24735	COG1051	belongs to the nudix hydrolase family
G3545_RS24740	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
G3545_RS24785	COG0583	DNA-binding transcription factor activity
G3545_RS24795	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G3545_RS24800	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G3545_RS24805	COG1126	abc transporter atp-binding protein
G3545_RS24820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G3545_RS24825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G3545_RS24830	COG0024	Methionine aminopeptidase
G3545_RS24835	COG2003	Belongs to the UPF0758 family
G3545_RS24850	COG0028	Belongs to the TPP enzyme family
G3545_RS24860	COG0523	cobalamin synthesis protein
G3545_RS24870	COG1802	Transcriptional regulator
G3545_RS24880	COG1960	acyl-CoA dehydrogenase activity
G3545_RS24890	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G3545_RS24895	COG1802	Transcriptional regulator
G3545_RS24905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3545_RS24930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3545_RS24935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3545_RS24950	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS24955	COG0673	inositol 2-dehydrogenase activity
G3545_RS24960	COG3246	L-lysine catabolic process to acetate
G3545_RS24970	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G3545_RS24975	COG2084	Dehydrogenase
G3545_RS24980	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS24990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G3545_RS24995	COG0697	spore germination
G3545_RS25005	COG2249	NAD(P)H dehydrogenase (quinone) activity
G3545_RS25015	COG0402	S-adenosylhomocysteine deaminase activity
G3545_RS25020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3545_RS25030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G3545_RS25050	COG2358	TRAP transporter, solute receptor (TAXI family
G3545_RS25055	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
G3545_RS25075	COG0803	Belongs to the bacterial solute-binding protein 9 family
G3545_RS25080	COG0523	cobalamin synthesis protein
G3545_RS25095	COG4689	acetoacetate decarboxylase
G3545_RS25105	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
G3545_RS25115	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
G3545_RS25120	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
G3545_RS25130	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS25145	COG0564	pseudouridine synthase activity
G3545_RS25150	COG0837	glucose binding
G3545_RS25155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G3545_RS25155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G3545_RS25165	COG0138	bifunctional purine biosynthesis protein purh
G3545_RS25170	COG2902	Dehydrogenase
G3545_RS25175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G3545_RS25180	COG2264	protein methyltransferase activity
G3545_RS25195	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G3545_RS25205	COG0181	hydroxymethylbilane synthase activity
G3545_RS25240	COG0271	Belongs to the BolA IbaG family
G3545_RS25245	COG4535	Mg2 and Co2 transporter CorC
G3545_RS25250	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
G3545_RS25255	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G3545_RS25265	COG4974	Belongs to the 'phage' integrase family
G3545_RS25270	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G3545_RS25275	COG0583	DNA-binding transcription factor activity
G3545_RS25280	COG0825	malonyl-CoA metabolic process
G3545_RS25285	COG3034	peptidoglycan biosynthetic process
G3545_RS25295	COG0653	protein targeting
G3545_RS25300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G3545_RS25340	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G3545_RS25350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G3545_RS25365	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
G3545_RS25370	COG1040	competence protein
G3545_RS25375	COG2226	methyltransferase
G3545_RS25385	COG0494	nUDIX hydrolase
G3545_RS25390	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
G3545_RS25395	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G3545_RS25400	COG0228	four-way junction DNA binding
G3545_RS25405	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G3545_RS25410	COG0336	Belongs to the RNA methyltransferase TrmD family
G3545_RS25415	COG0335	large ribosomal subunit rRNA binding
G3545_RS25430	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G3545_RS25460	COG0066	3-isopropylmalate dehydratase activity
G3545_RS25475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3545_RS25485	COG1309	transcriptional regulator
G3545_RS25495	COG0346	lactoylglutathione lyase activity
G3545_RS25510	COG0473	3-isopropylmalate dehydrogenase activity
G3545_RS25530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G3545_RS25535	COG0333	Belongs to the bacterial ribosomal protein bL32 family
G3545_RS25550	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
G3545_RS25555	COG0183	Belongs to the thiolase family
G3545_RS25575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G3545_RS25615	COG2890	protein-(glutamine-N5) methyltransferase activity
G3545_RS25620	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G3545_RS25635	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G3545_RS25640	COG0542	response to heat
G3545_RS25650	COG0330	HflC and HflK could
G3545_RS25665	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G3545_RS25675	COG2951	lytic endotransglycosylase activity
G3545_RS25690	COG0070	glutamate synthase
G3545_RS25690	COG0069	glutamate synthase activity
G3545_RS25690	COG0067	glutamate synthase
G3545_RS25700	COG0071	Belongs to the small heat shock protein (HSP20) family
G3545_RS25715	COG0483	inositol monophosphate 1-phosphatase activity
G3545_RS25740	COG0601	transmembrane transport
G3545_RS25745	COG4608	Belongs to the ABC transporter superfamily
G3545_RS25755	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G3545_RS25765	COG1609	Transcriptional regulator
G3545_RS25770	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G3545_RS25775	COG0747	negative chemotaxis
G3545_RS25780	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
G3545_RS25795	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G3545_RS25805	COG4221	oxidoreductase activity
G3545_RS25810	COG0596	Alpha beta hydrolase
G3545_RS25820	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS25825	COG1053	succinate dehydrogenase
G3545_RS25850	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
G3545_RS25860	COG1942	4-Oxalocrotonate Tautomerase
G3545_RS25880	COG4566	intracellular signal transduction
G3545_RS25930	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
G3545_RS25935	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
G3545_RS25995	COG1733	regulation of RNA biosynthetic process
G3545_RS26000	COG2183	response to ionizing radiation
G3545_RS26010	COG0709	Synthesizes selenophosphate from selenide and ATP
G3545_RS26015	COG1305	Transglutaminase-like
G3545_RS26030	COG0437	4 iron, 4 sulfur cluster binding
G3545_RS26035	COG2864	formate dehydrogenase
G3545_RS26045	COG1921	L-seryl-tRNASec selenium transferase activity
G3545_RS26075	COG1215	transferase activity, transferring glycosyl groups
G3545_RS26100	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
G3545_RS26105	COG0469	pyruvate kinase activity
G3545_RS26110	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
G3545_RS26135	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G3545_RS26140	COG0564	pseudouridine synthase activity
G3545_RS26160	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
G3545_RS26180	COG1129	ABC transporter
G3545_RS26185	COG4213	ABC transporter substrate-binding protein
G3545_RS26190	COG1172	Belongs to the binding-protein-dependent transport system permease family
G3545_RS26195	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G3545_RS26195	COG0519	Catalyzes the synthesis of GMP from XMP
G3545_RS26210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G3545_RS26215	COG4191	Histidine kinase
G3545_RS26220	COG0596	Alpha beta hydrolase
G3545_RS26250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G3545_RS26310	COG1294	oxidase, subunit
G3545_RS26315	COG1271	oxidase subunit
G3545_RS26325	COG0243	molybdopterin cofactor binding
G3545_RS26325	COG3383	formate dehydrogenase (NAD+) activity
G3545_RS26330	COG0437	4 iron, 4 sulfur cluster binding
G3545_RS26335	COG2864	formate dehydrogenase
G3545_RS26395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G3545_RS26400	COG1921	L-seryl-tRNASec selenium transferase activity
G3545_RS26420	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G3545_RS26425	COG0747	negative chemotaxis
G3545_RS26430	COG0601	transmembrane transport
G3545_RS26435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G3545_RS26450	COG2186	Transcriptional regulator
G3545_RS26475	COG4774	siderophore transport
G3545_RS26495	COG1120	ATPase activity
G3545_RS26500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G3545_RS26510	COG1802	Transcriptional regulator
G3545_RS26525	COG0765	amino acid transport
G3545_RS26535	COG1012	belongs to the aldehyde dehydrogenase family
G3545_RS26540	COG1012	belongs to the aldehyde dehydrogenase family
G3545_RS26555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G3545_RS26560	COG3284	Transcriptional regulator
G3545_RS26565	COG1063	alcohol dehydrogenase
G3545_RS26600	COG0459	protein refolding
G3545_RS26610	COG3284	Transcriptional regulator
G3545_RS26660	COG0583	DNA-binding transcription factor activity
G3545_RS26680	COG4774	siderophore transport
G3545_RS26685	COG1120	ATPase activity
G3545_RS26705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G3545_RS26730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3545_RS26735	COG1116	anion transmembrane transporter activity
G3545_RS26745	COG0546	phosphoglycolate phosphatase activity
G3545_RS26770	COG3485	protocatechuate 3,4-dioxygenase
G3545_RS26775	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS26780	COG3246	L-lysine catabolic process to acetate
G3545_RS26810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3545_RS26835	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G3545_RS26840	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
G3545_RS26845	COG2080	2 iron, 2 sulfur cluster binding
G3545_RS26850	COG1309	transcriptional regulator
G3545_RS26910	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G3545_RS26920	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
G3545_RS26925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3545_RS26935	COG1309	transcriptional regulator
G3545_RS26945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G3545_RS26990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G3545_RS27000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G3545_RS27030	COG1024	Enoyl-CoA hydratase
G3545_RS27035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G3545_RS27040	COG4948	Mandelate Racemase Muconate Lactonizing
G3545_RS27055	COG2197	response regulator
G3545_RS27065	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS27070	COG0583	DNA-binding transcription factor activity
G3545_RS27075	COG1132	(ABC) transporter
G3545_RS27080	COG0243	molybdopterin cofactor binding
G3545_RS27090	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G3545_RS27095	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G3545_RS27100	COG1017	nitric oxide dioxygenase activity
G3545_RS27100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G3545_RS27105	COG1116	anion transmembrane transporter activity
G3545_RS27115	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G3545_RS27130	COG1017	nitric oxide dioxygenase activity
G3545_RS27130	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G3545_RS27135	COG1959	2 iron, 2 sulfur cluster binding
G3545_RS27145	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G3545_RS27155	COG3842	ATPase activity
G3545_RS27165	COG1177	transmembrane transport
G3545_RS27175	COG0729	surface antigen
G3545_RS27185	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS27190	COG2186	Transcriptional regulator
G3545_RS27195	COG4948	Mandelate Racemase Muconate Lactonizing
G3545_RS27200	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
G3545_RS27205	COG0765	amino acid transport
G3545_RS27210	COG4948	Mandelate Racemase Muconate Lactonizing
G3545_RS27245	COG2205	protein histidine kinase activity
G3545_RS27325	COG0671	phosphoesterase, PA-phosphatase related
G3545_RS27350	COG2022	thiamine diphosphate biosynthetic process
G3545_RS27385	COG1218	3'(2'),5'-bisphosphate nucleotidase
G3545_RS27405	COG2201	protein-glutamate methylesterase activity
G3545_RS27420	COG0745	RESPONSE REGULATOR receiver
G3545_RS27440	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
G3545_RS27455	COG0514	ATP-dependent DNA helicase (RecQ)
G3545_RS27475	COG1492	cobalamin metabolic process
G3545_RS27550	COG1797	cobyrinic acid a,c-diamide synthase activity
G3545_RS27560	COG0058	SHG alpha-glucan phosphorylase activity
G3545_RS27565	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
G3545_RS27575	COG0297	glycogen (starch) synthase activity
G3545_RS27595	COG0725	ABC transporter, periplasmic molybdate-binding protein
G3545_RS27600	COG4149	molybdate abc transporter
G3545_RS27605	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
G3545_RS27640	COG4214	carbohydrate transport
G3545_RS27645	COG4213	ABC transporter substrate-binding protein
G3545_RS27650	COG1609	Transcriptional regulator
G3545_RS27655	COG1070	Carbohydrate kinase
G3545_RS27660	COG2115	Belongs to the xylose isomerase family
G3545_RS27675	COG0673	inositol 2-dehydrogenase activity
G3545_RS27685	COG1175	transmembrane transport
G3545_RS27690	COG0395	ABC-type sugar transport system, permease component
G3545_RS27700	COG3842	ATPase activity
G3545_RS27705	COG3842	ATPase activity
G3545_RS27710	COG1082	Xylose isomerase domain protein TIM barrel
G3545_RS27715	COG1461	Dihydroxyacetone kinase
G3545_RS27725	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G3545_RS27740	COG2376	Dihydroxyacetone kinase
G3545_RS27750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G3545_RS27755	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
G3545_RS27760	COG1024	Enoyl-CoA hydratase
G3545_RS27765	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G3545_RS27770	COG1802	Transcriptional regulator
G3545_RS27800	COG1802	Transcriptional regulator
G3545_RS27805	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
G3545_RS27810	COG0277	FAD linked oxidase domain protein
G3545_RS27810	COG0247	lactate metabolic process
G3545_RS27825	COG3729	General stress protein
G3545_RS27845	COG1733	regulation of RNA biosynthetic process
G3545_RS27850	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
G3545_RS27860	COG0482	sulfurtransferase activity
G3545_RS27875	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
G3545_RS27880	COG3454	Phosphonate metabolism
G3545_RS27885	COG4778	phosphonate C-P lyase system protein PhnL
G3545_RS27890	COG4107	phosphonate C-P lyase system protein PhnK
G3545_RS27895	COG3627	carbon phosphorus lyase activity
G3545_RS27900	COG3626	phosphonate metabolism
G3545_RS27905	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
G3545_RS27910	COG3624	Phosphonate C-P lyase system protein PhnG
G3545_RS27915	COG2188	Transcriptional regulator
G3545_RS27970	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
G3545_RS27980	COG0850	regulation of cytokinetic process
G3545_RS27995	COG3842	ATPase activity
G3545_RS28030	COG0435	Glutathione S-transferase
G3545_RS28055	COG0714	Associated with various cellular activities
G3545_RS28075	COG0617	tRNA 3'-terminal CCA addition
G3545_RS28100	COG0408	coproporphyrinogen oxidase activity
G3545_RS28105	COG1132	(ABC) transporter
G3545_RS28115	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
G3545_RS28120	COG0723	plastoquinol--plastocyanin reductase activity
G3545_RS28125	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
G3545_RS28125	COG2857	Cytochrome c1
G3545_RS28130	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
G3545_RS28130	COG2857	Cytochrome c1
G3545_RS28150	COG0012	GTP binding
G3545_RS28155	COG0193	aminoacyl-tRNA hydrolase activity
G3545_RS28160	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
G3545_RS28170	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G3545_RS28195	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
G3545_RS28220	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G3545_RS28225	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
G3545_RS28230	COG2205	protein histidine kinase activity
G3545_RS28235	COG0745	RESPONSE REGULATOR receiver
G3545_RS28240	COG1846	Transcriptional regulator
G3545_RS28250	COG0314	molybdopterin synthase activity
G3545_RS28260	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G3545_RS28265	COG0322	excinuclease ABC activity
G3545_RS28270	COG0697	spore germination
G3545_RS28275	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS28280	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
G3545_RS28285	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
G3545_RS28290	COG0625	glutathione transferase activity
G3545_RS28295	COG1278	Cold shock
G3545_RS28300	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
G3545_RS28330	COG1335	isochorismatase
G3545_RS28335	COG0556	nucleotide-excision repair
G3545_RS28340	COG3152	Membrane
G3545_RS28345	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G3545_RS28360	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
G3545_RS28370	COG1671	Belongs to the UPF0178 family
G3545_RS28375	COG0405	Gamma-glutamyltransferase
G3545_RS28420	COG0531	amino acid
G3545_RS28425	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
G3545_RS28435	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
G3545_RS28460	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS28465	COG1028	Short-chain dehydrogenase reductase Sdr
G3545_RS28470	COG1116	anion transmembrane transporter activity
G3545_RS28475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G3545_RS28490	COG0546	phosphoglycolate phosphatase activity
G3545_RS28500	COG0434	BtpA family
G3545_RS28505	COG1349	DNA-binding transcription factor activity
G3545_RS28515	COG3842	ATPase activity
G3545_RS28520	COG0395	ABC-type sugar transport system, permease component
G3545_RS28530	COG1175	transmembrane transport
G3545_RS28535	COG1704	LemA family
G3545_RS28540	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
G3545_RS28550	COG2169	Transcriptional regulator
G3545_RS28550	COG1917	Cupin 2, conserved barrel domain protein
G3545_RS28565	COG1176	ABC-type spermidine putrescine transport system, permease component I
G3545_RS28570	COG1177	transmembrane transport
G3545_RS28575	COG3938	Belongs to the proline racemase family
G3545_RS28585	COG3795	YCII-related domain
G3545_RS28590	COG4941	Belongs to the sigma-70 factor family
G3545_RS28620	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
G3545_RS28645	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G3545_RS28655	COG2824	Alkylphosphonate utilization operon protein PhnA
G3545_RS28675	COG0667	Aldo Keto reductase
G3545_RS28685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G3545_RS28690	COG0473	3-isopropylmalate dehydrogenase activity
G3545_RS28710	COG0028	Belongs to the TPP enzyme family
G3545_RS28715	COG2188	Transcriptional regulator
G3545_RS28720	COG0129	dihydroxy-acid dehydratase activity
G3545_RS28730	COG2223	nitrite transmembrane transporter activity
G3545_RS28755	COG3161	chorismate lyase activity
G3545_RS28770	COG1271	oxidase subunit
G3545_RS28775	COG0243	molybdopterin cofactor binding
G3545_RS28790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G3545_RS28795	COG2140	Oxalate decarboxylase
G3545_RS28820	COG3180	Ammonia monooxygenase
G3545_RS28830	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
G3545_RS28835	COG1802	Transcriptional regulator
G3545_RS28840	COG2079	MmgE PrpD family protein
G3545_RS28845	COG1053	succinate dehydrogenase
G3545_RS28860	COG2423	ornithine cyclodeaminase activity
G3545_RS28885	COG0835	chemotaxis
G3545_RS28890	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
G3545_RS28890	COG0457	Tetratricopeptide repeat
G3545_RS28905	COG2201	protein-glutamate methylesterase activity
G3545_RS28910	COG5001	Diguanylate cyclase
G3545_RS28910	COG2203	Gaf domain
G3545_RS28910	COG3706	GGDEF domain
G3545_RS28910	COG4251	negative regulation of phosphorylation
G3545_RS28920	COG0644	oxidoreductase
G3545_RS28940	COG1320	monovalent cation:proton antiporter activity
G3545_RS28945	COG2212	antiporter activity
G3545_RS28950	COG1863	multisubunit Na H antiporter MnhE subunit
G3545_RS28955	COG0651	ATP synthesis coupled electron transport
G3545_RS28960	COG1006	Multisubunit Na H antiporter MnhC subunit
G3545_RS28965	COG2111	Na H antiporter
G3545_RS28965	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G3545_RS28990	COG4221	oxidoreductase activity
G3545_RS29000	COG1280	lysine exporter protein (LysE YggA)
G3545_RS29010	COG2382	esterase
G3545_RS29015	COG2423	ornithine cyclodeaminase activity
G3545_RS29065	COG1279	arginine transmembrane transporter activity
G3545_RS29075	COG3850	Histidine kinase
G3545_RS29075	COG4999	Histidine kinase
G3545_RS29075	COG3437	response regulator, receiver
G3545_RS29075	COG2205	protein histidine kinase activity
G3545_RS29110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G3545_RS29130	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
G3545_RS29160	COG1289	transmembrane transporter activity
G3545_RS29170	COG1566	PFAM secretion protein HlyD family protein
G3545_RS29175	COG0477	Major facilitator Superfamily
G3545_RS29210	COG1177	transmembrane transport
G3545_RS29230	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
G3545_RS29290	COG2968	Membrane
G3545_RS29310	COG4095	Psort location CytoplasmicMembrane, score
G3545_RS29320	COG2133	pyrroloquinoline quinone binding
G3545_RS29330	COG0625	glutathione transferase activity
G3545_RS29335	COG0436	Aminotransferase
G3545_RS29350	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G3545_RS29360	COG4651	solute:proton antiporter activity
G3545_RS29360	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G3545_RS29370	COG0583	DNA-binding transcription factor activity
G3545_RS29375	COG0492	ferredoxin-NADP+ reductase activity
G3545_RS29380	COG1522	sequence-specific DNA binding
G3545_RS29410	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G3545_RS29415	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G3545_RS29435	COG0505	Belongs to the CarA family