locus-tag	class	description
AOT14_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AOT14_RS00010	COG0592	DNA-directed DNA polymerase activity
AOT14_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AOT14_RS00020	COG0187	DNA topoisomerase II activity
AOT14_RS00030	COG0501	Belongs to the peptidase M48B family
AOT14_RS00070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AOT14_RS00080	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AOT14_RS00095	COG4772	TonB-dependent receptor
AOT14_RS00105	COG0800	Aldolase
AOT14_RS00110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AOT14_RS00130	COG2272	Belongs to the type-B carboxylesterase lipase family
AOT14_RS00135	COG0657	acetylesterase activity
AOT14_RS00135	COG2755	lipolytic protein G-D-S-L family
AOT14_RS00145	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AOT14_RS00160	COG1609	Transcriptional regulator
AOT14_RS00165	COG1028	Short-chain dehydrogenase reductase Sdr
AOT14_RS00175	COG0302	gtp cyclohydrolase
AOT14_RS00180	COG3788	relative of glutathione S-transferase, MAPEG superfamily
AOT14_RS00185	COG4206	TonB-dependent receptor
AOT14_RS00205	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AOT14_RS00210	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
AOT14_RS00215	COG0676	glucose-6-phosphate 1-epimerase activity
AOT14_RS00220	COG3135	benzoate transporter
AOT14_RS00260	COG4942	peptidase
AOT14_RS00265	COG0793	Belongs to the peptidase S41A family
AOT14_RS00300	COG1565	acr, cog1565
AOT14_RS00300	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AOT14_RS00305	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AOT14_RS00310	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AOT14_RS00355	COG0358	DNA primase activity
AOT14_RS00360	COG1295	ribonuclease BN
AOT14_RS00365	COG1610	YqeY-like protein
AOT14_RS00375	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AOT14_RS00380	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AOT14_RS00385	COG0668	transmembrane transport
AOT14_RS00400	COG2133	pyrroloquinoline quinone binding
AOT14_RS00405	COG1301	dicarboxylic acid transport
AOT14_RS00415	COG1737	Transcriptional regulator
AOT14_RS00420	COG4948	Mandelate Racemase Muconate Lactonizing
AOT14_RS00440	COG0019	diaminopimelate decarboxylase activity
AOT14_RS00445	COG3023	N-Acetylmuramoyl-L-alanine amidase
AOT14_RS00460	COG3023	N-Acetylmuramoyl-L-alanine amidase
AOT14_RS00465	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AOT14_RS00470	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AOT14_RS00495	COG5383	Protein conserved in bacteria
AOT14_RS00505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOT14_RS00510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOT14_RS00515	COG1473	amidohydrolase
AOT14_RS00520	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AOT14_RS00520	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AOT14_RS00525	COG1652	LysM domain
AOT14_RS00550	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AOT14_RS00555	COG3118	belongs to the thioredoxin family
AOT14_RS00565	COG2884	Cell division ATP-binding protein ftsE
AOT14_RS00570	COG2177	Part of the ABC transporter FtsEX involved in
AOT14_RS00575	COG2201	protein-glutamate methylesterase activity
AOT14_RS00580	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AOT14_RS00585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AOT14_RS00595	COG1252	NADH dehydrogenase
AOT14_RS00605	COG0625	glutathione transferase activity
AOT14_RS00615	COG3537	Alpha-1,2-mannosidase
AOT14_RS00620	COG1609	Transcriptional regulator
AOT14_RS00630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AOT14_RS00640	COG3250	beta-galactosidase activity
AOT14_RS00660	COG4585	Histidine kinase
AOT14_RS00670	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AOT14_RS00685	COG0534	Mate efflux family protein
AOT14_RS00690	COG0616	signal peptide processing
AOT14_RS00700	COG1028	Short-chain dehydrogenase reductase Sdr
AOT14_RS00710	COG0745	RESPONSE REGULATOR receiver
AOT14_RS00725	COG0009	L-threonylcarbamoyladenylate synthase
AOT14_RS00730	COG1754	DNA topoisomerase type I activity
AOT14_RS00730	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AOT14_RS00735	COG1714	RDD family
AOT14_RS00745	COG2922	Belongs to the Smg family
AOT14_RS00750	COG0758	DNA mediated transformation
AOT14_RS00760	COG0242	peptide deformylase activity
AOT14_RS00765	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AOT14_RS00770	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AOT14_RS00770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AOT14_RS00780	COG1215	transferase activity, transferring glycosyl groups
AOT14_RS00815	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AOT14_RS00825	COG1490	D-aminoacyl-tRNA deacylase activity
AOT14_RS00830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AOT14_RS00835	COG3537	Alpha-1,2-mannosidase
AOT14_RS00845	COG0582	viral genome integration into host DNA
AOT14_RS00850	COG1309	transcriptional regulator
AOT14_RS00865	COG1764	response to oxidative stress
AOT14_RS00875	COG2217	Heavy metal translocating P-type atpase
AOT14_RS00880	COG4716	Myosin-crossreactive antigen
AOT14_RS00885	COG1250	3-hydroxyacyl-CoA dehydrogenase
AOT14_RS00900	COG0210	DNA helicase
AOT14_RS00920	COG0514	ATP-dependent DNA helicase (RecQ)
AOT14_RS00955	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AOT14_RS00970	COG1401	restriction endodeoxyribonuclease activity
AOT14_RS00990	COG5377	YqaJ viral recombinase family
AOT14_RS01025	COG4983	Phage plasmid primase, P4 family domain protein
AOT14_RS01065	COG0464	growth
AOT14_RS01090	COG3275	phosphorelay sensor kinase activity
AOT14_RS01105	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AOT14_RS01130	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AOT14_RS01140	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
AOT14_RS01150	COG1595	DNA-templated transcription, initiation
AOT14_RS01160	COG0302	gtp cyclohydrolase
AOT14_RS01165	COG3046	protein related to deoxyribodipyrimidine photolyase
AOT14_RS01185	COG2200	EAL domain
AOT14_RS01190	COG3706	GGDEF domain
AOT14_RS01205	COG5002	protein histidine kinase activity
AOT14_RS01205	COG5001	Diguanylate cyclase
AOT14_RS01250	COG3795	YCII-related domain
AOT14_RS01255	COG3795	YCII-related domain
AOT14_RS01270	COG5507	3-demethylubiquinone-9 3-methyltransferase
AOT14_RS01275	COG4941	Belongs to the sigma-70 factor family
AOT14_RS01285	COG2972	Histidine kinase
AOT14_RS01310	COG3590	peptidase
AOT14_RS01320	COG0583	DNA-binding transcription factor activity
AOT14_RS01325	COG3384	dioxygenase
AOT14_RS01330	COG0025	NhaP-type Na H and K H
AOT14_RS01380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOT14_RS01395	COG2205	protein histidine kinase activity
AOT14_RS01395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AOT14_RS01405	COG1187	pseudouridine synthase activity
AOT14_RS01410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AOT14_RS01420	COG1666	GTP binding
AOT14_RS01430	COG0697	spore germination
AOT14_RS01440	COG2011	ABC-type metal ion transport system permease component
AOT14_RS01465	COG0508	dehydrogenase complex catalyzes the overall conversion of
AOT14_RS01470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AOT14_RS01485	COG0356	it plays a direct role in the translocation of protons across the membrane
AOT14_RS01495	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AOT14_RS01500	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AOT14_RS01505	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AOT14_RS01510	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AOT14_RS01515	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AOT14_RS01520	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AOT14_RS01530	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AOT14_RS01535	COG4191	Histidine kinase
AOT14_RS01545	COG1136	(ABC) transporter
AOT14_RS01545	COG0577	efflux transmembrane transporter activity
AOT14_RS01565	COG0577	efflux transmembrane transporter activity
AOT14_RS01565	COG1136	(ABC) transporter
AOT14_RS01570	COG1136	(ABC) transporter
AOT14_RS01570	COG0577	efflux transmembrane transporter activity
AOT14_RS01575	COG1136	(ABC) transporter
AOT14_RS01575	COG0577	efflux transmembrane transporter activity
AOT14_RS01580	COG0577	efflux transmembrane transporter activity
AOT14_RS01580	COG1136	(ABC) transporter
AOT14_RS01585	COG0577	efflux transmembrane transporter activity
AOT14_RS01585	COG1136	(ABC) transporter
AOT14_RS01590	COG1136	(ABC) transporter
AOT14_RS01600	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AOT14_RS01610	COG0457	Tetratricopeptide repeat
AOT14_RS01610	COG3710	Transcriptional regulator
AOT14_RS01660	COG2132	Multicopper oxidase
AOT14_RS01675	COG0339	signal peptide processing
AOT14_RS01725	COG1803	Methylglyoxal synthase
AOT14_RS01730	COG0493	'glutamate synthase
AOT14_RS01735	COG0069	glutamate synthase activity
AOT14_RS01735	COG0067	glutamate synthase
AOT14_RS01735	COG0070	glutamate synthase
AOT14_RS01770	COG1205	dead DEAH box helicase
AOT14_RS01770	COG1111	helicase
AOT14_RS01800	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AOT14_RS01805	COG2885	chlorophyll binding
AOT14_RS01835	COG0714	Associated with various cellular activities
AOT14_RS01885	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AOT14_RS01895	COG2062	phosphohistidine phosphatase, SixA
AOT14_RS01905	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AOT14_RS01925	COG2199	diguanylate cyclase activity
AOT14_RS01925	COG2200	EAL domain
AOT14_RS01925	COG2202	Pas domain
AOT14_RS01955	COG1968	undecaprenyl-diphosphatase activity
AOT14_RS01960	COG0174	glutamine synthetase
AOT14_RS01970	COG0004	ammonium transporteR
AOT14_RS01975	COG3852	Histidine kinase
AOT14_RS01980	COG2204	response regulator
AOT14_RS01985	COG2815	serine threonine protein kinase
AOT14_RS01985	COG0515	serine threonine protein kinase
AOT14_RS01990	COG2032	superoxide dismutase activity
AOT14_RS01995	COG2032	superoxide dismutase activity
AOT14_RS02005	COG0183	Belongs to the thiolase family
AOT14_RS02050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AOT14_RS02055	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AOT14_RS02060	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AOT14_RS02070	COG1028	Short-chain dehydrogenase reductase Sdr
AOT14_RS02090	COG3474	cytochrome
AOT14_RS02105	COG0454	-acetyltransferase
AOT14_RS02140	COG3039	Transposase
AOT14_RS02155	COG0129	dihydroxy-acid dehydratase activity
AOT14_RS02165	COG0754	glutathionylspermidine amidase activity
AOT14_RS02180	COG0714	Associated with various cellular activities
AOT14_RS02210	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AOT14_RS02255	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AOT14_RS02285	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AOT14_RS02290	COG1040	competence protein
AOT14_RS02300	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AOT14_RS02315	COG2207	Transcriptional regulator
AOT14_RS02325	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AOT14_RS02350	COG0606	chelatase, subunit chli
AOT14_RS02365	COG3039	Transposase
AOT14_RS02405	COG0251	oxidation-reduction process
AOT14_RS02410	COG0583	DNA-binding transcription factor activity
AOT14_RS02415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AOT14_RS02425	COG3039	Transposase
AOT14_RS02435	COG3039	Transposase
AOT14_RS02450	COG0662	Cupin 2, conserved barrel domain protein
AOT14_RS02475	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AOT14_RS02480	COG0625	glutathione transferase activity
AOT14_RS02510	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AOT14_RS02525	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AOT14_RS02535	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AOT14_RS02540	COG0604	alcohol dehydrogenase
AOT14_RS02645	COG2826	transposase and inactivated derivatives, IS30 family
AOT14_RS02660	COG0606	chelatase, subunit chli
AOT14_RS02665	COG2960	long-chain fatty acid transporting porin activity
AOT14_RS02690	COG1166	arginine decarboxylase activity
AOT14_RS02695	COG4221	oxidoreductase activity
AOT14_RS02705	COG0018	arginyl-trna synthetase
AOT14_RS02715	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AOT14_RS02735	COG2205	protein histidine kinase activity
AOT14_RS02745	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AOT14_RS02750	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AOT14_RS02770	COG0708	Exodeoxyribonuclease III
AOT14_RS02775	COG2223	nitrite transmembrane transporter activity
AOT14_RS02785	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AOT14_RS02790	COG0739	heme binding
AOT14_RS02795	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AOT14_RS02835	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AOT14_RS02840	COG0546	phosphoglycolate phosphatase activity
AOT14_RS02845	COG4206	TonB-dependent receptor
AOT14_RS02850	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AOT14_RS02855	COG0406	alpha-ribazole phosphatase activity
AOT14_RS02860	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AOT14_RS02870	COG1956	GAF domain-containing protein
AOT14_RS02885	COG0720	synthase
AOT14_RS02890	COG0513	Belongs to the DEAD box helicase family
AOT14_RS02900	COG0625	glutathione transferase activity
AOT14_RS02930	COG0626	cystathionine gamma-synthase activity
AOT14_RS02940	COG1450	Type ii and iii secretion system protein
AOT14_RS02990	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AOT14_RS02995	COG1459	type II secretion system
AOT14_RS03015	COG0438	transferase activity, transferring glycosyl groups
AOT14_RS03015	COG1216	Glycosyl transferase, family 2
AOT14_RS03025	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AOT14_RS03030	COG2076	Multidrug Resistance protein
AOT14_RS03045	COG0318	PFAM AMP-dependent synthetase and ligase
AOT14_RS03050	COG1028	Short-chain dehydrogenase reductase Sdr
AOT14_RS03105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AOT14_RS03125	COG2409	Drug exporters of the RND superfamily
AOT14_RS03145	COG0181	hydroxymethylbilane synthase activity
AOT14_RS03170	COG0826	peptidase U32
AOT14_RS03175	COG0826	peptidase U32
AOT14_RS03180	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AOT14_RS03190	COG3154	lipid carrier protein
AOT14_RS03210	COG1505	serine-type exopeptidase activity
AOT14_RS03215	COG0436	Aminotransferase
AOT14_RS03225	COG2832	Protein of unknown function (DUF454)
AOT14_RS03235	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AOT14_RS03260	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AOT14_RS03265	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AOT14_RS03270	COG1309	transcriptional regulator
AOT14_RS03275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOT14_RS03280	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOT14_RS03295	COG2226	methyltransferase
AOT14_RS03300	COG0308	aminopeptidase N
AOT14_RS03320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AOT14_RS03325	COG1077	Cell shape determining protein MreB Mrl
AOT14_RS03330	COG1792	Involved in formation and maintenance of cell shape
AOT14_RS03340	COG0768	penicillin binding
AOT14_RS03345	COG0772	Belongs to the SEDS family
AOT14_RS03350	COG2951	lytic endotransglycosylase activity
AOT14_RS03360	COG1686	Belongs to the peptidase S11 family
AOT14_RS03375	COG2921	Belongs to the UPF0250 family
AOT14_RS03380	COG0321	lipoyl(octanoyl) transferase activity
AOT14_RS03385	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AOT14_RS03405	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AOT14_RS03415	COG4251	negative regulation of phosphorylation
AOT14_RS03420	COG0784	Response regulator, receiver
AOT14_RS03425	COG4191	Histidine kinase
AOT14_RS03430	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AOT14_RS03450	COG0662	Cupin 2, conserved barrel domain protein
AOT14_RS03455	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AOT14_RS03460	COG3876	Protein conserved in bacteria
AOT14_RS03465	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AOT14_RS03475	COG0837	glucose binding
AOT14_RS03480	COG3525	Glycosyl hydrolase, family 20, catalytic domain
AOT14_RS03490	COG0837	glucose binding
AOT14_RS03495	COG0738	Major facilitator superfamily
AOT14_RS03500	COG1609	Transcriptional regulator
AOT14_RS03505	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AOT14_RS03510	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AOT14_RS03525	COG0617	tRNA 3'-terminal CCA addition
AOT14_RS03550	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AOT14_RS03565	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AOT14_RS03570	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AOT14_RS03615	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AOT14_RS03620	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AOT14_RS03625	COG2203	Gaf domain
AOT14_RS03625	COG3706	GGDEF domain
AOT14_RS03625	COG5001	Diguanylate cyclase
AOT14_RS03625	COG4251	negative regulation of phosphorylation
AOT14_RS03640	COG1307	EDD domain protein, DegV family
AOT14_RS03645	COG1228	amidohydrolase
AOT14_RS03650	COG3964	amidohydrolase
AOT14_RS03660	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AOT14_RS03670	COG0513	Belongs to the DEAD box helicase family
AOT14_RS03690	COG0436	Aminotransferase
AOT14_RS03695	COG1162	GTPase activity
AOT14_RS03705	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AOT14_RS03710	COG4206	TonB-dependent receptor
AOT14_RS03720	COG0583	DNA-binding transcription factor activity
AOT14_RS03725	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOT14_RS03730	COG0405	Gamma-glutamyltransferase
AOT14_RS03735	COG3119	arylsulfatase activity
AOT14_RS03740	COG0641	radical SAM
AOT14_RS03745	COG0405	Gamma-glutamyltransferase
AOT14_RS03750	COG0786	glutamate:sodium symporter activity
AOT14_RS03760	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AOT14_RS03765	COG1737	Transcriptional regulator
AOT14_RS03770	COG2610	gluconate transmembrane transporter activity
AOT14_RS03785	COG2197	response regulator
AOT14_RS03795	COG3916	Acyl-homoserine-lactone synthase
AOT14_RS03805	COG0297	glycogen (starch) synthase activity
AOT14_RS03815	COG1560	Kdo2-lipid A biosynthetic process
AOT14_RS03820	COG1519	Transferase
AOT14_RS03825	COG1538	Outer membrane efflux protein
AOT14_RS03830	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AOT14_RS03880	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AOT14_RS03880	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AOT14_RS03885	COG0778	Nitroreductase
AOT14_RS03940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AOT14_RS03965	COG1295	ribonuclease BN
AOT14_RS03970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AOT14_RS04000	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AOT14_RS04005	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AOT14_RS04020	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AOT14_RS04030	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AOT14_RS04040	COG0193	aminoacyl-tRNA hydrolase activity
AOT14_RS04045	COG0012	GTP binding
AOT14_RS04050	COG4771	TonB-dependent receptor
AOT14_RS04060	COG1446	asparaginase
AOT14_RS04080	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AOT14_RS04095	COG0250	Participates in transcription elongation, termination and antitermination
AOT14_RS04100	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AOT14_RS04105	COG0081	regulation of translation
AOT14_RS04110	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AOT14_RS04115	COG0222	ribosome binding
AOT14_RS04120	COG0085	RNA polymerase activity
AOT14_RS04125	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AOT14_RS04130	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AOT14_RS04140	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AOT14_RS04145	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AOT14_RS04155	COG0051	transcription antitermination factor activity, RNA binding
AOT14_RS04160	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AOT14_RS04165	COG0088	Forms part of the polypeptide exit tunnel
AOT14_RS04170	COG0089	rRNA binding
AOT14_RS04175	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AOT14_RS04180	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AOT14_RS04185	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AOT14_RS04190	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AOT14_RS04195	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AOT14_RS04200	COG0255	Belongs to the universal ribosomal protein uL29 family
AOT14_RS04205	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AOT14_RS04215	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AOT14_RS04220	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AOT14_RS04225	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AOT14_RS04230	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AOT14_RS04240	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AOT14_RS04245	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AOT14_RS04250	COG1841	ribosomal large subunit assembly
AOT14_RS04255	COG0200	Binds to the 23S rRNA
AOT14_RS04260	COG0201	protein transport
AOT14_RS04265	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AOT14_RS04275	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AOT14_RS04280	COG0202	RNA polymerase activity
AOT14_RS04285	COG0203	ribosomal protein L17
AOT14_RS04290	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AOT14_RS04295	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AOT14_RS04305	COG0154	amidase activity
AOT14_RS04315	COG1217	gtp-binding protein TYPA
AOT14_RS04320	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AOT14_RS04335	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AOT14_RS04350	COG2205	protein histidine kinase activity
AOT14_RS04355	COG0745	RESPONSE REGULATOR receiver
AOT14_RS04370	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AOT14_RS04375	COG0625	glutathione transferase activity
AOT14_RS04385	COG3039	Transposase
AOT14_RS04390	COG0446	pyridine nucleotide-disulphide oxidoreductase
AOT14_RS04390	COG1902	pentaerythritol trinitrate reductase activity
AOT14_RS04410	COG1187	pseudouridine synthase activity
AOT14_RS04430	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AOT14_RS04435	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AOT14_RS04440	COG4208	sulfate ABC transporter
AOT14_RS04445	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AOT14_RS04460	COG1063	alcohol dehydrogenase
AOT14_RS04475	COG0588	phosphoglycerate mutase activity
AOT14_RS04485	COG0285	dihydrofolate synthase activity
AOT14_RS04505	COG2833	Protein of unknown function (DUF455)
AOT14_RS04520	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AOT14_RS04530	COG0438	transferase activity, transferring glycosyl groups
AOT14_RS04535	COG0248	Ppx GppA phosphatase
AOT14_RS04540	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AOT14_RS04545	COG5002	protein histidine kinase activity
AOT14_RS04555	COG4783	chaperone-mediated protein folding
AOT14_RS04570	COG0473	3-isopropylmalate dehydrogenase activity
AOT14_RS04610	COG0544	peptidyl-prolyl cis-trans isomerase activity
AOT14_RS04620	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AOT14_RS04655	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AOT14_RS04660	COG1388	LysM domain
AOT14_RS04660	COG3942	CHAP domain
AOT14_RS04665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AOT14_RS04680	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AOT14_RS04685	COG0631	protein serine/threonine phosphatase activity
AOT14_RS04700	COG0859	PFAM glycosyl transferase family 9
AOT14_RS04705	COG3642	lipopolysaccharide core region biosynthetic process
AOT14_RS04710	COG1234	tRNA 3'-trailer cleavage
AOT14_RS04715	COG0582	viral genome integration into host DNA
AOT14_RS04745	COG0587	DNA-directed DNA polymerase activity
AOT14_RS04785	COG5377	YqaJ viral recombinase family
AOT14_RS04795	COG2801	Transposase and inactivated derivatives
AOT14_RS04800	COG2826	transposase and inactivated derivatives, IS30 family
AOT14_RS04810	COG2801	Transposase and inactivated derivatives
AOT14_RS04835	COG3039	Transposase
AOT14_RS04885	COG3039	Transposase
AOT14_RS04900	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AOT14_RS04915	COG0537	adenosine 5'-monophosphoramidase activity
AOT14_RS04930	COG1305	Transglutaminase-like
AOT14_RS04940	COG0714	Associated with various cellular activities
AOT14_RS04965	COG1399	metal-binding, possibly nucleic acid-binding protein
AOT14_RS04970	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AOT14_RS04975	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AOT14_RS04990	COG1028	Short-chain dehydrogenase reductase Sdr
AOT14_RS05000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AOT14_RS05005	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AOT14_RS05010	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AOT14_RS05035	COG3540	Alkaline phosphatase
AOT14_RS05095	COG2818	Glycosylase
AOT14_RS05110	COG0540	Belongs to the ATCase OTCase family
AOT14_RS05125	COG2239	Acts as a magnesium transporter
AOT14_RS05130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AOT14_RS05145	COG1660	Displays ATPase and GTPase activities
AOT14_RS05150	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AOT14_RS05155	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AOT14_RS05170	COG1137	ATPase activity
AOT14_RS05185	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AOT14_RS05200	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AOT14_RS05210	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AOT14_RS05215	COG0564	pseudouridine synthase activity
AOT14_RS05230	COG3011	Protein conserved in bacteria
AOT14_RS05235	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
AOT14_RS05240	COG3387	PFAM Glycoside hydrolase 15-related
AOT14_RS05245	COG1877	trehalose-phosphatase activity
AOT14_RS05285	COG1858	cytochrome C peroxidase
AOT14_RS05295	COG4771	TonB-dependent receptor
AOT14_RS05305	COG1595	DNA-templated transcription, initiation
AOT14_RS05310	COG0542	response to heat
AOT14_RS05325	COG0583	DNA-binding transcription factor activity
AOT14_RS05330	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AOT14_RS05330	COG4651	solute:proton antiporter activity
AOT14_RS05335	COG4771	TonB-dependent receptor
AOT14_RS05340	COG0488	(ABC) transporter
AOT14_RS05375	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AOT14_RS05395	COG4771	TonB-dependent receptor
AOT14_RS05405	COG0217	transcriptional regulatory protein
AOT14_RS05410	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AOT14_RS05415	COG0632	four-way junction helicase activity
AOT14_RS05425	COG2255	four-way junction helicase activity
AOT14_RS05430	COG0824	Thioesterase
AOT14_RS05455	COG2885	chlorophyll binding
AOT14_RS05465	COG0602	queuosine metabolic process
AOT14_RS05470	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AOT14_RS05485	COG2815	serine threonine protein kinase
AOT14_RS05485	COG0515	serine threonine protein kinase
AOT14_RS05495	COG0783	Belongs to the Dps family
AOT14_RS05500	COG1643	Atp-dependent helicase
AOT14_RS05515	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AOT14_RS05530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AOT14_RS05540	COG1199	ATP-dependent helicase activity
AOT14_RS05545	COG1214	PFAM Peptidase M22, glycoprotease
AOT14_RS05560	COG0384	phenazine biosynthesis protein PhzF
AOT14_RS05565	COG0527	aspartate kinase activity
AOT14_RS05575	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AOT14_RS05585	COG0142	geranyltranstransferase activity
AOT14_RS05590	COG0366	Alpha amylase catalytic
AOT14_RS05600	COG1082	Xylose isomerase domain protein TIM barrel
AOT14_RS05605	COG2190	(PTS) system
AOT14_RS05605	COG2211	Major facilitator Superfamily
AOT14_RS05635	COG0629	single-stranded DNA binding
AOT14_RS05645	COG0431	NADPH-dependent FMN reductase
AOT14_RS05660	COG0798	PFAM Bile acid sodium symporter
AOT14_RS05670	COG2197	response regulator
AOT14_RS05680	COG4948	Mandelate Racemase Muconate Lactonizing
AOT14_RS05690	COG4771	TonB-dependent receptor
AOT14_RS05700	COG3104	oligopeptide transport
AOT14_RS05705	COG1297	OPT oligopeptide transporter protein
AOT14_RS05710	COG0823	Involved in the tonB-independent uptake of proteins
AOT14_RS05710	COG1506	peptidase
AOT14_RS05725	COG2879	small protein
AOT14_RS05730	COG1966	Carbon starvation protein
AOT14_RS05745	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AOT14_RS05750	COG1741	Belongs to the pirin family
AOT14_RS05755	COG1515	deoxyribonuclease V activity
AOT14_RS05760	COG0588	phosphoglycerate mutase activity
AOT14_RS05790	COG3590	peptidase
AOT14_RS05810	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AOT14_RS05820	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AOT14_RS05825	COG0745	RESPONSE REGULATOR receiver
AOT14_RS05830	COG2205	protein histidine kinase activity
AOT14_RS05835	COG5002	protein histidine kinase activity
AOT14_RS05835	COG5001	Diguanylate cyclase
AOT14_RS05840	COG4452	Inner membrane protein CreD
AOT14_RS05870	COG0824	Thioesterase
AOT14_RS05875	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AOT14_RS05885	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AOT14_RS05895	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AOT14_RS05905	COG0728	peptidoglycan biosynthetic process
AOT14_RS05915	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AOT14_RS05925	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AOT14_RS05940	COG3039	Transposase
AOT14_RS05950	COG4974	Belongs to the 'phage' integrase family
AOT14_RS05975	COG2963	transposase activity
AOT14_RS05980	COG4771	TonB-dependent receptor
AOT14_RS06005	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AOT14_RS06010	COG1845	cytochrome c oxidase, subunit III
AOT14_RS06015	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AOT14_RS06040	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AOT14_RS06045	COG2070	2-Nitropropane dioxygenase
AOT14_RS06060	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AOT14_RS06065	COG0336	Belongs to the RNA methyltransferase TrmD family
AOT14_RS06070	COG0335	large ribosomal subunit rRNA binding
AOT14_RS06075	COG1349	DNA-binding transcription factor activity
AOT14_RS06085	COG1940	carbohydrate kinase activity
AOT14_RS06090	COG2222	sugar isomerase
AOT14_RS06095	COG1501	Belongs to the glycosyl hydrolase 31 family
AOT14_RS06105	COG0673	inositol 2-dehydrogenase activity
AOT14_RS06110	COG0534	Mate efflux family protein
AOT14_RS06130	COG0753	catalase activity
AOT14_RS06140	COG1827	regulation of RNA biosynthetic process
AOT14_RS06165	COG3706	GGDEF domain
AOT14_RS06170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AOT14_RS06200	COG2217	Heavy metal translocating P-type atpase
AOT14_RS06220	COG2010	Cytochrome c
AOT14_RS06230	COG3278	Belongs to the heme-copper respiratory oxidase family
AOT14_RS06235	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
AOT14_RS06240	COG1024	Enoyl-CoA hydratase
AOT14_RS06240	COG1250	3-hydroxyacyl-CoA dehydrogenase
AOT14_RS06255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AOT14_RS06260	COG0481	GTPase activity
AOT14_RS06265	COG0681	Belongs to the peptidase S26 family
AOT14_RS06280	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AOT14_RS06295	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AOT14_RS06300	COG2954	triphosphatase activity
AOT14_RS06305	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AOT14_RS06310	COG1472	Belongs to the glycosyl hydrolase 3 family
AOT14_RS06315	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AOT14_RS06320	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AOT14_RS06325	COG1278	Cold shock
AOT14_RS06330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOT14_RS06355	COG2801	Transposase and inactivated derivatives
AOT14_RS06365	COG0840	transmembrane signaling receptor activity
AOT14_RS06365	COG0840	transmembrane signaling receptor activity
AOT14_RS06385	COG1960	acyl-CoA dehydrogenase activity
AOT14_RS06400	COG0183	Belongs to the thiolase family
AOT14_RS06415	COG1703	isobutyryl-CoA mutase activity
AOT14_RS06415	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AOT14_RS06415	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AOT14_RS06425	COG1619	proteins homologs of microcin C7 resistance protein MccF
AOT14_RS06430	COG1228	amidohydrolase
AOT14_RS06455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AOT14_RS06460	COG5001	Diguanylate cyclase
AOT14_RS06460	COG5002	protein histidine kinase activity
AOT14_RS06460	COG3447	MASE1 domain protein
AOT14_RS06465	COG0204	Acyl-transferase
AOT14_RS06490	COG2814	Major facilitator Superfamily
AOT14_RS06505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AOT14_RS06510	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AOT14_RS06530	COG1451	nucleotide metabolic process
AOT14_RS06540	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AOT14_RS06575	COG2824	Alkylphosphonate utilization operon protein PhnA
AOT14_RS06605	COG0392	lysyltransferase activity
AOT14_RS06605	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AOT14_RS06615	COG0251	oxidation-reduction process
AOT14_RS06620	COG2733	membrane
AOT14_RS06645	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AOT14_RS06655	COG0477	Major facilitator Superfamily
AOT14_RS06660	COG2703	oxygen carrier activity
AOT14_RS06670	COG0745	RESPONSE REGULATOR receiver
AOT14_RS06700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOT14_RS06710	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AOT14_RS06715	COG3842	ATPase activity
AOT14_RS06720	COG1176	ABC-type spermidine putrescine transport system, permease component I
AOT14_RS06725	COG1177	transmembrane transport
AOT14_RS06730	COG1012	belongs to the aldehyde dehydrogenase family
AOT14_RS06750	COG4535	Mg2 and Co2 transporter CorC
AOT14_RS06765	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AOT14_RS06775	COG1702	phosphate starvation-inducible protein PhoH
AOT14_RS06780	COG1309	transcriptional regulator
AOT14_RS06790	COG1131	(ABC) transporter
AOT14_RS06795	COG0842	Transport permease protein
AOT14_RS06795	COG1129	ABC transporter
AOT14_RS06800	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AOT14_RS06805	COG0741	lytic transglycosylase activity
AOT14_RS06810	COG0723	plastoquinol--plastocyanin reductase activity
AOT14_RS06815	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AOT14_RS06820	COG2857	Cytochrome c1
AOT14_RS06825	COG0625	glutathione transferase activity
AOT14_RS06830	COG2969	positive regulation of protein catabolic process
AOT14_RS06870	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AOT14_RS06875	COG0300	oxidoreductase activity
AOT14_RS06880	COG2095	MarC family integral membrane protein
AOT14_RS06890	COG1611	Belongs to the LOG family
AOT14_RS06895	COG3275	phosphorelay sensor kinase activity
AOT14_RS06940	COG0556	nucleotide-excision repair
AOT14_RS06950	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AOT14_RS06955	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AOT14_RS06970	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AOT14_RS07000	COG0348	domain, Protein
AOT14_RS07025	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AOT14_RS07030	COG0069	glutamate synthase activity
AOT14_RS07035	COG0493	'glutamate synthase
AOT14_RS07055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AOT14_RS07065	COG1253	flavin adenine dinucleotide binding
AOT14_RS07075	COG0306	phosphate transporter
AOT14_RS07095	COG0504	CTP synthase activity
AOT14_RS07100	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AOT14_RS07110	COG0148	phosphopyruvate hydratase activity
AOT14_RS07115	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AOT14_RS07120	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AOT14_RS07125	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AOT14_RS07135	COG2840	Smr protein MutS2
AOT14_RS07140	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AOT14_RS07150	COG1238	metal cluster binding
AOT14_RS07170	COG1534	Rna-binding protein
AOT14_RS07175	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AOT14_RS07180	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AOT14_RS07185	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AOT14_RS07190	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AOT14_RS07200	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AOT14_RS07215	COG0688	phosphatidylethanolamine metabolic process
AOT14_RS07225	COG2890	protein-(glutamine-N5) methyltransferase activity
AOT14_RS07230	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AOT14_RS07235	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AOT14_RS07240	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AOT14_RS07255	COG0101	tRNA pseudouridine synthase activity
AOT14_RS07260	COG0135	phosphoribosylanthranilate isomerase activity
AOT14_RS07270	COG0133	tryptophan synthase activity
AOT14_RS07280	COG0159	tryptophan synthase activity
AOT14_RS07285	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AOT14_RS07285	COG2755	lipolytic protein G-D-S-L family
AOT14_RS07290	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AOT14_RS07295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AOT14_RS07300	COG0726	polysaccharide deacetylase
AOT14_RS07315	COG0149	triose-phosphate isomerase activity
AOT14_RS07330	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AOT14_RS07335	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AOT14_RS07340	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AOT14_RS07345	COG0649	NAD binding
AOT14_RS07350	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AOT14_RS07355	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AOT14_RS07395	COG1007	ATP synthesis coupled electron transport
AOT14_RS07405	COG0779	Required for maturation of 30S ribosomal subunits
AOT14_RS07410	COG0195	Participates in both transcription termination and antitermination
AOT14_RS07415	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AOT14_RS07420	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AOT14_RS07430	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AOT14_RS07450	COG0848	biopolymer transport protein
AOT14_RS07460	COG1663	tetraacyldisaccharide 4'-kinase activity
AOT14_RS07465	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AOT14_RS07470	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AOT14_RS07480	COG0322	excinuclease ABC activity
AOT14_RS07525	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AOT14_RS07535	COG1960	acyl-CoA dehydrogenase activity
AOT14_RS07555	COG3712	iron ion homeostasis
AOT14_RS07560	COG1228	amidohydrolase
AOT14_RS07565	COG1473	amidohydrolase
AOT14_RS07570	COG3040	lipid binding
AOT14_RS07605	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AOT14_RS07615	COG1570	exodeoxyribonuclease VII activity
AOT14_RS07620	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AOT14_RS07625	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AOT14_RS07625	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AOT14_RS07630	COG0802	atpase or kinase
AOT14_RS07635	COG0860	N-Acetylmuramoyl-L-alanine amidase
AOT14_RS07640	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AOT14_RS07660	COG1028	Short-chain dehydrogenase reductase Sdr
AOT14_RS07665	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AOT14_RS07670	COG0501	Belongs to the peptidase M48B family
AOT14_RS07695	COG5001	Diguanylate cyclase
AOT14_RS07695	COG3300	MHYT domain
AOT14_RS07700	COG1509	lysine 2,3-aminomutase activity
AOT14_RS07705	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AOT14_RS07710	COG3548	integral membrane protein
AOT14_RS07715	COG0402	S-adenosylhomocysteine deaminase activity
AOT14_RS07720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AOT14_RS07755	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AOT14_RS07780	COG2166	iron-sulfur cluster assembly
AOT14_RS07795	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AOT14_RS07800	COG0137	argininosuccinate synthase activity
AOT14_RS07805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AOT14_RS07810	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AOT14_RS07825	COG0165	Argininosuccinate lyase
AOT14_RS07865	COG1294	oxidase, subunit
AOT14_RS07875	COG4988	ABC transporter
AOT14_RS07880	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AOT14_RS07885	COG1793	dna ligase
AOT14_RS07890	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AOT14_RS07900	COG4235	cytochrome complex assembly
AOT14_RS07905	COG3088	subunit of a heme lyase
AOT14_RS07910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AOT14_RS07920	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AOT14_RS07950	COG0436	Aminotransferase
AOT14_RS07970	COG1187	pseudouridine synthase activity
AOT14_RS07975	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AOT14_RS07980	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AOT14_RS07985	COG2350	Protein conserved in bacteria
AOT14_RS08020	COG0395	ABC-type sugar transport system, permease component
AOT14_RS08035	COG0800	Aldolase
AOT14_RS08040	COG0129	dihydroxy-acid dehydratase activity
AOT14_RS08050	COG0837	glucose binding
AOT14_RS08055	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AOT14_RS08075	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AOT14_RS08100	COG4591	ABC-type transport system involved in lipoprotein release permease component
AOT14_RS08115	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AOT14_RS08120	COG1194	a g-specific adenine glycosylase
AOT14_RS08125	COG0552	protein localization to endoplasmic reticulum
AOT14_RS08135	COG0326	Molecular chaperone. Has ATPase activity
AOT14_RS08140	COG0742	ribosomal rna small subunit methyltransferase
AOT14_RS08145	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AOT14_RS08155	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AOT14_RS08160	COG0405	Gamma-glutamyltransferase
AOT14_RS08170	COG3135	benzoate transporter
AOT14_RS08180	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AOT14_RS08185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AOT14_RS08200	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AOT14_RS08225	COG0583	DNA-binding transcription factor activity
AOT14_RS08250	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AOT14_RS08255	COG1522	sequence-specific DNA binding
AOT14_RS08260	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AOT14_RS08265	COG0343	queuine tRNA-ribosyltransferase activity
AOT14_RS08270	COG1862	Preprotein translocase
AOT14_RS08280	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AOT14_RS08285	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AOT14_RS08290	COG2200	EAL domain
AOT14_RS08295	COG2081	HI0933 family
AOT14_RS08310	COG1278	Cold shock
AOT14_RS08315	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AOT14_RS08320	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AOT14_RS08325	COG0513	Belongs to the DEAD box helicase family
AOT14_RS08335	COG0583	DNA-binding transcription factor activity
AOT14_RS08340	COG0488	(ABC) transporter
AOT14_RS08360	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AOT14_RS08370	COG3104	oligopeptide transport
AOT14_RS08390	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AOT14_RS08395	COG0339	signal peptide processing
AOT14_RS08400	COG0386	Belongs to the glutathione peroxidase family
AOT14_RS08425	COG2860	membrane
AOT14_RS08430	COG2860	membrane
AOT14_RS08455	COG1393	Belongs to the ArsC family
AOT14_RS08485	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AOT14_RS08490	COG0084	hydrolase, TatD family'
AOT14_RS08525	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AOT14_RS08530	COG1183	phosphatidylcholine synthase activity
AOT14_RS08540	COG3243	poly(R)-hydroxyalkanoic acid synthase
AOT14_RS08560	COG2183	response to ionizing radiation
AOT14_RS08610	COG1028	Short-chain dehydrogenase reductase Sdr
AOT14_RS08615	COG1335	isochorismatase
AOT14_RS08635	COG2823	Periplasmic or secreted lipoprotein
AOT14_RS08675	COG1064	alcohol dehydrogenase
AOT14_RS08680	COG1473	amidohydrolase
AOT14_RS08685	COG1595	DNA-templated transcription, initiation
AOT14_RS08690	COG4944	Protein of unknown function (DUF1109)
AOT14_RS08730	COG0840	transmembrane signaling receptor activity
AOT14_RS08735	COG3300	MHYT domain
AOT14_RS08735	COG5001	Diguanylate cyclase
AOT14_RS08740	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AOT14_RS08760	COG4644	lycopene metabolic process
AOT14_RS08825	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AOT14_RS08885	COG0010	Belongs to the arginase family
AOT14_RS08890	COG2986	histidine ammonia-lyase
AOT14_RS08895	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AOT14_RS08900	COG2188	Transcriptional regulator
AOT14_RS08910	COG4771	TonB-dependent receptor
AOT14_RS08920	COG2871	sodium ion transport
AOT14_RS08935	COG4771	TonB-dependent receptor
AOT14_RS08945	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOT14_RS08950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOT14_RS09005	COG0789	Transcriptional regulator
AOT14_RS09020	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AOT14_RS09030	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AOT14_RS09035	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AOT14_RS09040	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AOT14_RS09045	COG2217	Heavy metal translocating P-type atpase
AOT14_RS09070	COG5002	protein histidine kinase activity
AOT14_RS09095	COG0789	Transcriptional regulator
AOT14_RS09135	COG3039	Transposase
AOT14_RS09165	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AOT14_RS09245	COG0666	response to abiotic stimulus
AOT14_RS09270	COG3039	Transposase
AOT14_RS09295	COG3142	Participates in the control of copper homeostasis
AOT14_RS09300	COG1446	asparaginase
AOT14_RS09305	COG0837	glucose binding
AOT14_RS09310	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AOT14_RS09315	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AOT14_RS09320	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AOT14_RS09325	COG1674	ftsk spoiiie
AOT14_RS09330	COG0492	ferredoxin-NADP+ reductase activity
AOT14_RS09335	COG1408	metallophosphoesterase
AOT14_RS09365	COG0542	response to heat
AOT14_RS09385	COG0482	sulfurtransferase activity
AOT14_RS09390	COG2915	High frequency lysogenization protein hflD homolog
AOT14_RS09420	COG5002	protein histidine kinase activity
AOT14_RS09440	COG0835	chemotaxis
AOT14_RS09440	COG0784	Response regulator, receiver
AOT14_RS09455	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AOT14_RS09460	COG1749	Flagellar hook protein flgE
AOT14_RS09465	COG4787	bacterial-type flagellum-dependent cell motility
AOT14_RS09475	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AOT14_RS09540	COG2201	protein-glutamate methylesterase activity
AOT14_RS09560	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AOT14_RS09585	COG1216	Glycosyl transferase, family 2
AOT14_RS09585	COG0438	transferase activity, transferring glycosyl groups
AOT14_RS09595	COG1766	The M ring may be actively involved in energy transduction
AOT14_RS09600	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AOT14_RS09640	COG3190	flagellar
AOT14_RS09645	COG1338	Plays a role in the flagellum-specific transport system
AOT14_RS09700	COG2198	Histidine kinase
AOT14_RS09700	COG0784	Response regulator, receiver
AOT14_RS09700	COG0643	Histidine kinase
AOT14_RS09705	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AOT14_RS09720	COG0835	chemotaxis
AOT14_RS09730	COG0745	RESPONSE REGULATOR receiver
AOT14_RS09745	COG0840	transmembrane signaling receptor activity
AOT14_RS09750	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
AOT14_RS09755	COG0835	chemotaxis
AOT14_RS09765	COG0840	transmembrane signaling receptor activity
AOT14_RS09770	COG0840	transmembrane signaling receptor activity
AOT14_RS09770	COG0840	transmembrane signaling receptor activity
AOT14_RS09815	COG1228	amidohydrolase
AOT14_RS09870	COG1017	nitric oxide dioxygenase activity
AOT14_RS09870	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AOT14_RS09885	COG3047	cAMP biosynthetic process
AOT14_RS09885	COG2885	chlorophyll binding
AOT14_RS09900	COG1024	Enoyl-CoA hydratase
AOT14_RS09905	COG0784	Response regulator, receiver
AOT14_RS09905	COG2205	protein histidine kinase activity
AOT14_RS09905	COG2198	Histidine kinase
AOT14_RS09915	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AOT14_RS09920	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AOT14_RS09935	COG3279	Response regulator of the LytR AlgR family
AOT14_RS09945	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AOT14_RS09955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AOT14_RS09960	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AOT14_RS09970	COG0505	Belongs to the CarA family
AOT14_RS09975	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AOT14_RS09980	COG2249	NAD(P)H dehydrogenase (quinone) activity
AOT14_RS09990	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AOT14_RS09990	COG1918	ferrous iron import across plasma membrane
AOT14_RS10025	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AOT14_RS10045	COG0277	FAD linked oxidase domain protein
AOT14_RS10050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AOT14_RS10060	COG0531	amino acid
AOT14_RS10065	COG0531	amino acid
AOT14_RS10070	COG0235	Class ii aldolase
AOT14_RS10075	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AOT14_RS10080	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AOT14_RS10085	COG1285	pathogenesis
AOT14_RS10100	COG0531	amino acid
AOT14_RS10110	COG3485	protocatechuate 3,4-dioxygenase
AOT14_RS10135	COG0140	phosphoribosyl-ATP diphosphatase activity
AOT14_RS10135	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AOT14_RS10145	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AOT14_RS10150	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AOT14_RS10155	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AOT14_RS10155	COG0131	Imidazoleglycerol-phosphate dehydratase
AOT14_RS10160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AOT14_RS10165	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AOT14_RS10170	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AOT14_RS10180	COG0124	histidyl-tRNA synthetase
AOT14_RS10185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AOT14_RS10195	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AOT14_RS10225	COG1012	belongs to the aldehyde dehydrogenase family
AOT14_RS10240	COG0167	dihydroorotate dehydrogenase activity
AOT14_RS10245	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AOT14_RS10300	COG3451	type IV secretory pathway VirB4
AOT14_RS10310	COG3838	Conjugal transfer protein Trbc
AOT14_RS10315	COG4962	Type ii secretion system protein e
AOT14_RS10335	COG0583	DNA-binding transcription factor activity
AOT14_RS10350	COG1028	Short-chain dehydrogenase reductase Sdr
AOT14_RS10365	COG1309	transcriptional regulator
AOT14_RS10380	COG1131	(ABC) transporter
AOT14_RS10385	COG0842	Transport permease protein
AOT14_RS10390	COG0842	Transport permease protein
AOT14_RS10405	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AOT14_RS10410	COG1611	Belongs to the LOG family
AOT14_RS10430	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
AOT14_RS10440	COG4959	Type IV secretory pathway protease TraF
AOT14_RS10455	COG1192	Involved in chromosome partitioning
AOT14_RS10460	COG3039	Transposase
AOT14_RS10490	COG5489	Protein of unknown function (DUF736)
AOT14_RS10525	COG2003	Belongs to the UPF0758 family
AOT14_RS10540	COG0582	viral genome integration into host DNA
AOT14_RS10545	COG0519	Catalyzes the synthesis of GMP from XMP
AOT14_RS10545	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AOT14_RS10560	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AOT14_RS10565	COG1160	GTP binding
AOT14_RS10570	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AOT14_RS10580	COG1426	Protein conserved in bacteria
AOT14_RS10590	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AOT14_RS10595	COG0105	UTP biosynthetic process
AOT14_RS10605	COG1024	Enoyl-CoA hydratase
AOT14_RS10605	COG1250	3-hydroxyacyl-CoA dehydrogenase
AOT14_RS10610	COG0183	Belongs to the thiolase family
AOT14_RS10625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AOT14_RS10630	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AOT14_RS10640	COG0776	regulation of translation
AOT14_RS10650	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AOT14_RS10655	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AOT14_RS10665	COG2957	Belongs to the agmatine deiminase family
AOT14_RS10670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AOT14_RS10695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOT14_RS10725	COG0316	Belongs to the HesB IscA family
AOT14_RS10725	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AOT14_RS10730	COG2154	pterin-4-alpha-carbinolamine dehydratase
AOT14_RS10745	COG1530	ribonuclease E activity
AOT14_RS10755	COG0671	phosphoesterase, PA-phosphatase related
AOT14_RS10760	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AOT14_RS10770	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AOT14_RS10775	COG1028	Short-chain dehydrogenase reductase Sdr
AOT14_RS10805	COG0305	Participates in initiation and elongation during chromosome replication
AOT14_RS10815	COG0367	asparagine synthase
AOT14_RS10820	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AOT14_RS10825	COG0625	glutathione transferase activity
AOT14_RS10840	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AOT14_RS10860	COG0583	DNA-binding transcription factor activity
AOT14_RS10865	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AOT14_RS10880	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AOT14_RS10885	COG0077	Prephenate dehydratase
AOT14_RS10885	COG1605	Chorismate mutase
AOT14_RS10890	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AOT14_RS10935	COG0166	Belongs to the GPI family
AOT14_RS10940	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AOT14_RS10945	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AOT14_RS10950	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AOT14_RS10960	COG0617	tRNA 3'-terminal CCA addition
AOT14_RS10970	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AOT14_RS10980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AOT14_RS10990	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AOT14_RS10995	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AOT14_RS11015	COG0351	phosphomethylpyrimidine kinase
AOT14_RS11040	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AOT14_RS11060	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AOT14_RS11080	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AOT14_RS11085	COG0360	Binds together with S18 to 16S ribosomal RNA
AOT14_RS11090	COG0316	Belongs to the HesB IscA family
AOT14_RS11095	COG0017	Asparaginyl-tRNA synthetase
AOT14_RS11110	COG2808	Putative FMN-binding domain
AOT14_RS11115	COG0288	reversible hydration of carbon dioxide
AOT14_RS11125	COG3844	kynureninase activity
AOT14_RS11130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOT14_RS11135	COG2925	Exonuclease
AOT14_RS11160	COG1278	Cold shock
AOT14_RS11180	COG2902	Dehydrogenase
AOT14_RS11190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOT14_RS11195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOT14_RS11205	COG2826	transposase and inactivated derivatives, IS30 family
AOT14_RS11210	COG2963	transposase activity
AOT14_RS11220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOT14_RS11225	COG1960	acyl-CoA dehydrogenase activity
AOT14_RS11230	COG2226	methyltransferase
AOT14_RS11250	COG0583	DNA-binding transcription factor activity
AOT14_RS11255	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AOT14_RS11260	COG2814	Major facilitator Superfamily
AOT14_RS11270	COG2900	Belongs to the SlyX family
AOT14_RS11285	COG0386	Belongs to the glutathione peroxidase family
AOT14_RS11295	COG1725	Transcriptional regulator
AOT14_RS11300	COG1131	(ABC) transporter
AOT14_RS11335	COG0840	transmembrane signaling receptor activity
AOT14_RS11350	COG2850	peptidyl-arginine hydroxylation
AOT14_RS11360	COG0567	Dehydrogenase, E1 component
AOT14_RS11370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AOT14_RS11385	COG1595	DNA-templated transcription, initiation
AOT14_RS11400	COG1132	(ABC) transporter
AOT14_RS11415	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AOT14_RS11420	COG0484	heat shock protein binding
AOT14_RS11425	COG0443	Heat shock 70 kDa protein
AOT14_RS11430	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AOT14_RS11435	COG0497	DNA recombination
AOT14_RS11445	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AOT14_RS11460	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AOT14_RS11485	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AOT14_RS11490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AOT14_RS11505	COG0583	DNA-binding transcription factor activity
AOT14_RS11510	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AOT14_RS11540	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AOT14_RS11545	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AOT14_RS11550	COG2137	regulation of response to DNA damage stimulus
AOT14_RS11555	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AOT14_RS11565	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AOT14_RS11570	COG1546	Belongs to the CinA family
AOT14_RS11580	COG0433	COG0433 Predicted ATPase
AOT14_RS11585	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AOT14_RS11595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AOT14_RS11600	COG0412	Dienelactone hydrolase
AOT14_RS11610	COG0717	Belongs to the dCTP deaminase family
AOT14_RS11615	COG0489	protein tyrosine kinase activity
AOT14_RS11620	COG4771	TonB-dependent receptor
AOT14_RS11625	COG0457	Tetratricopeptide repeat
AOT14_RS11635	COG3590	peptidase
AOT14_RS11655	COG0697	spore germination
AOT14_RS11665	COG2311	Membrane
AOT14_RS11670	COG1047	Peptidyl-prolyl cis-trans
AOT14_RS11675	COG0791	NLP P60 protein
AOT14_RS11680	COG0791	NLP P60 protein
AOT14_RS11685	COG0612	Peptidase, M16
AOT14_RS11690	COG0612	Peptidase, M16
AOT14_RS11695	COG1301	dicarboxylic acid transport
AOT14_RS11705	COG0037	tRNA processing
AOT14_RS11710	COG1722	exodeoxyribonuclease VII activity
AOT14_RS11715	COG0142	geranyltranstransferase activity
AOT14_RS11725	COG0312	modulator of DNA gyrase
AOT14_RS11730	COG3028	Belongs to the UPF0307 family
AOT14_RS11740	COG0312	modulator of DNA gyrase
AOT14_RS11755	COG0424	maF-like protein
AOT14_RS11760	COG2968	Membrane
AOT14_RS11780	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AOT14_RS11790	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AOT14_RS11805	COG0495	leucyl-tRNA aminoacylation
AOT14_RS11840	COG5001	Diguanylate cyclase
AOT14_RS11840	COG4251	negative regulation of phosphorylation
AOT14_RS11840	COG3706	GGDEF domain
AOT14_RS11840	COG2203	Gaf domain
AOT14_RS11865	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AOT14_RS11870	COG0346	lactoylglutathione lyase activity
AOT14_RS11875	COG1131	(ABC) transporter
AOT14_RS11890	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AOT14_RS11890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AOT14_RS11915	COG0116	Belongs to the methyltransferase superfamily
AOT14_RS11915	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AOT14_RS11935	COG0494	nUDIX hydrolase
AOT14_RS11945	COG1024	Enoyl-CoA hydratase
AOT14_RS11955	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AOT14_RS11965	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AOT14_RS11970	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AOT14_RS11975	COG0573	inorganic phosphate transmembrane transporter activity
AOT14_RS11980	COG0581	inorganic phosphate transmembrane transporter activity
AOT14_RS11990	COG0704	Plays a role in the regulation of phosphate uptake
AOT14_RS11995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AOT14_RS12000	COG0557	exoribonuclease II activity
AOT14_RS12020	COG2814	Major facilitator Superfamily
AOT14_RS12025	COG1566	PFAM secretion protein HlyD family protein
AOT14_RS12070	COG0367	asparagine synthase
AOT14_RS12075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AOT14_RS12080	COG1393	Belongs to the ArsC family
AOT14_RS12090	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AOT14_RS12095	COG0024	Methionine aminopeptidase
AOT14_RS12100	COG0052	Belongs to the universal ribosomal protein uS2 family
AOT14_RS12105	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AOT14_RS12115	COG0528	UMP kinase activity
AOT14_RS12120	COG0233	cytoplasmic translational termination
AOT14_RS12130	COG0575	Belongs to the CDS family
AOT14_RS12135	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AOT14_RS12140	COG0750	zinc metalloprotease
AOT14_RS12145	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AOT14_RS12150	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AOT14_RS12160	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AOT14_RS12180	COG0825	malonyl-CoA metabolic process
AOT14_RS12185	COG1981	membrane
AOT14_RS12250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AOT14_RS12295	COG1132	(ABC) transporter
AOT14_RS12310	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AOT14_RS12335	COG1187	pseudouridine synthase activity
AOT14_RS12420	COG0735	belongs to the Fur family
AOT14_RS12425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AOT14_RS12435	COG1250	3-hydroxyacyl-CoA dehydrogenase
AOT14_RS12435	COG1024	Enoyl-CoA hydratase
AOT14_RS12440	COG1946	Acyl-CoA thioesterase
AOT14_RS12450	COG1595	DNA-templated transcription, initiation
AOT14_RS12460	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AOT14_RS12470	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AOT14_RS12495	COG1073	alpha beta
AOT14_RS12510	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AOT14_RS12525	COG2197	response regulator
AOT14_RS12530	COG4585	Histidine kinase
AOT14_RS12540	COG0850	regulation of cytokinetic process
AOT14_RS12545	COG2894	cell division
AOT14_RS12550	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AOT14_RS12560	COG2205	protein histidine kinase activity
AOT14_RS12570	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AOT14_RS12580	COG2194	sulfuric ester hydrolase activity
AOT14_RS12600	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AOT14_RS12630	COG2814	Major facilitator Superfamily
AOT14_RS12635	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AOT14_RS12635	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AOT14_RS12650	COG1917	Cupin 2, conserved barrel domain protein
AOT14_RS12650	COG2207	Transcriptional regulator
AOT14_RS12665	COG1846	Transcriptional regulator
AOT14_RS12715	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AOT14_RS12725	COG0330	HflC and HflK could
AOT14_RS12730	COG0330	HflC and HflK could
AOT14_RS12735	COG0604	alcohol dehydrogenase
AOT14_RS12755	COG0678	peroxiredoxin activity
AOT14_RS12765	COG4953	penicillin-binding protein 1C
AOT14_RS12770	COG2373	Large extracellular alpha-helical protein
AOT14_RS12800	COG0372	Belongs to the citrate synthase family
AOT14_RS12835	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AOT14_RS12855	COG2814	Major facilitator Superfamily
AOT14_RS12870	COG3038	cytochrome b561
AOT14_RS12890	COG1760	l-serine dehydratase
AOT14_RS12905	COG0527	aspartate kinase activity
AOT14_RS12905	COG0460	homoserine dehydrogenase
AOT14_RS12910	COG0626	cystathionine gamma-synthase activity
AOT14_RS12915	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AOT14_RS12920	COG0739	heme binding
AOT14_RS12925	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AOT14_RS12930	COG1272	protein, Hemolysin III
AOT14_RS12935	COG2982	Protein involved in outer membrane biogenesis
AOT14_RS12940	COG0617	tRNA 3'-terminal CCA addition
AOT14_RS12940	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AOT14_RS12940	COG3620	sequence-specific DNA binding
AOT14_RS12945	COG0463	Glycosyl transferase, family 2
AOT14_RS12950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AOT14_RS12955	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AOT14_RS12980	COG1960	acyl-CoA dehydrogenase activity
AOT14_RS13020	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AOT14_RS13030	COG0330	HflC and HflK could
AOT14_RS13035	COG1742	UPF0060 membrane protein
AOT14_RS13040	COG3956	TIGRFAM MazG family protein
AOT14_RS13045	COG1218	3'(2'),5'-bisphosphate nucleotidase
AOT14_RS13050	COG0494	nUDIX hydrolase
AOT14_RS13055	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AOT14_RS13075	COG0840	transmembrane signaling receptor activity
AOT14_RS13080	COG0835	chemotaxis
AOT14_RS13095	COG0189	ligase activity
AOT14_RS13125	COG1764	response to oxidative stress
AOT14_RS13150	COG1959	2 iron, 2 sulfur cluster binding
AOT14_RS13155	COG0719	Fe-S assembly protein
AOT14_RS13165	COG0396	ATPase activity
AOT14_RS13170	COG0719	Fe-S assembly protein
AOT14_RS13175	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AOT14_RS13190	COG4774	siderophore transport
AOT14_RS13200	COG3128	pkhd-type hydroxylase
AOT14_RS13210	COG4771	TonB-dependent receptor
AOT14_RS13230	COG1477	protein flavinylation
AOT14_RS13255	COG1028	Short-chain dehydrogenase reductase Sdr
AOT14_RS13285	COG0640	Transcriptional regulator
AOT14_RS13300	COG2205	protein histidine kinase activity
AOT14_RS13305	COG4771	TonB-dependent receptor
AOT14_RS13310	COG2610	gluconate transmembrane transporter activity
AOT14_RS13315	COG1555	photosystem II stabilization
AOT14_RS13330	COG3178	'Phosphotransferase
AOT14_RS13335	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AOT14_RS13345	COG0628	permease
AOT14_RS13355	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AOT14_RS13370	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AOT14_RS13385	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AOT14_RS13390	COG0045	succinate-CoA ligase (ADP-forming) activity
AOT14_RS13410	COG5001	Diguanylate cyclase
AOT14_RS13420	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AOT14_RS13440	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AOT14_RS13475	COG1459	type II secretion system
AOT14_RS13480	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AOT14_RS13495	COG0745	RESPONSE REGULATOR receiver
AOT14_RS13505	COG0189	ligase activity
AOT14_RS13525	COG2022	thiamine diphosphate biosynthetic process
AOT14_RS13535	COG0471	metal ion transport
AOT14_RS13535	COG3273	potassium ion transport
AOT14_RS13565	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AOT14_RS13565	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AOT14_RS13570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AOT14_RS13575	COG1115	amino acid carrier protein
AOT14_RS13585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOT14_RS13590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOT14_RS13595	COG2895	sulfate adenylyltransferase (ATP) activity
AOT14_RS13595	COG0529	Catalyzes the synthesis of activated sulfate
AOT14_RS13605	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AOT14_RS13610	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AOT14_RS13615	COG0175	sulfate reduction
AOT14_RS13635	COG0583	DNA-binding transcription factor activity
AOT14_RS13650	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AOT14_RS13655	COG3588	fructose-bisphosphate aldolase
AOT14_RS13660	COG0469	pyruvate kinase activity
AOT14_RS13670	COG0126	phosphoglycerate kinase activity
AOT14_RS13675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AOT14_RS13690	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AOT14_RS13720	COG0427	acetyl-CoA hydrolase
AOT14_RS13735	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AOT14_RS13740	COG1301	dicarboxylic acid transport
AOT14_RS13770	COG0714	Associated with various cellular activities
AOT14_RS13800	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AOT14_RS13815	COG0254	rRNA binding
AOT14_RS13825	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AOT14_RS13835	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AOT14_RS13840	COG1758	RNA polymerase activity
AOT14_RS13855	COG1561	YicC-like family, N-terminal region
AOT14_RS13860	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AOT14_RS13865	COG0346	lactoylglutathione lyase activity
AOT14_RS13875	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AOT14_RS13890	COG0006	proline dipeptidase activity
AOT14_RS13895	COG0006	proline dipeptidase activity
AOT14_RS13900	COG3079	Belongs to the UPF0149 family
AOT14_RS13915	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AOT14_RS13950	COG2912	Transglutaminase-like superfamily
AOT14_RS13960	COG0352	thiamine-phosphate diphosphorylase activity
AOT14_RS13970	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AOT14_RS13980	COG0537	adenosine 5'-monophosphoramidase activity
AOT14_RS13985	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AOT14_RS13990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AOT14_RS13995	COG1028	Short-chain dehydrogenase reductase Sdr
AOT14_RS14010	COG0671	phosphoesterase, PA-phosphatase related
AOT14_RS14020	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AOT14_RS14025	COG0563	adenylate kinase activity
AOT14_RS14050	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
AOT14_RS14080	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AOT14_RS14085	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AOT14_RS14090	COG0405	Gamma-glutamyltransferase
AOT14_RS14135	COG3267	Type II secretory pathway component ExeA
AOT14_RS14135	COG3409	Peptidoglycan-binding domain 1 protein
AOT14_RS14175	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AOT14_RS14195	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AOT14_RS14210	COG0473	3-isopropylmalate dehydrogenase activity
AOT14_RS14215	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AOT14_RS14240	COG2963	transposase activity
AOT14_RS14245	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AOT14_RS14265	COG3634	alkyl hydroperoxide reductase activity
AOT14_RS14270	COG0583	DNA-binding transcription factor activity
AOT14_RS14275	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AOT14_RS14290	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AOT14_RS14305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AOT14_RS14315	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AOT14_RS14335	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AOT14_RS14340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOT14_RS14345	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOT14_RS14350	COG2096	Adenosyltransferase
AOT14_RS14360	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AOT14_RS14365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AOT14_RS14370	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AOT14_RS14375	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AOT14_RS14380	COG2967	ApaG domain
AOT14_RS14385	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AOT14_RS14400	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AOT14_RS14405	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AOT14_RS14425	COG0861	Integral membrane protein TerC family
AOT14_RS14430	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AOT14_RS14435	COG0642	Histidine kinase
AOT14_RS14455	COG4771	TonB-dependent receptor
AOT14_RS14465	COG0667	Aldo Keto reductase
AOT14_RS14470	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AOT14_RS14480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AOT14_RS14505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOT14_RS14530	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AOT14_RS14535	COG1607	acyl-coa hydrolase
AOT14_RS14540	COG0515	serine threonine protein kinase
AOT14_RS14540	COG2815	serine threonine protein kinase
AOT14_RS14545	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AOT14_RS14555	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AOT14_RS14565	COG0456	acetyltransferase
AOT14_RS14580	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AOT14_RS14590	COG0494	nUDIX hydrolase
AOT14_RS14595	COG0653	protein targeting
AOT14_RS14600	COG0739	heme binding
AOT14_RS14610	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AOT14_RS14615	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AOT14_RS14625	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AOT14_RS14650	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AOT14_RS14665	COG3116	cell division
AOT14_RS14670	COG0275	rRNA processing
AOT14_RS14675	COG2001	Belongs to the MraZ family
AOT14_RS14695	COG0792	nuclease activity
AOT14_RS14700	COG1988	membrane-bound metal-dependent
AOT14_RS14705	COG0277	FAD linked oxidase domain protein
AOT14_RS14715	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AOT14_RS14720	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AOT14_RS14735	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AOT14_RS14735	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AOT14_RS14745	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AOT14_RS14750	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AOT14_RS14760	COG0488	(ABC) transporter
AOT14_RS14765	COG2252	PERMEase
AOT14_RS14775	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AOT14_RS14780	COG3118	belongs to the thioredoxin family
AOT14_RS14780	COG0457	Tetratricopeptide repeat
AOT14_RS14785	COG1215	transferase activity, transferring glycosyl groups
AOT14_RS14790	COG1215	transferase activity, transferring glycosyl groups
AOT14_RS14800	COG2194	sulfuric ester hydrolase activity
AOT14_RS14815	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AOT14_RS14820	COG0457	Tetratricopeptide repeat
AOT14_RS14825	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AOT14_RS14830	COG1215	transferase activity, transferring glycosyl groups
AOT14_RS14835	COG1215	transferase activity, transferring glycosyl groups
AOT14_RS14860	COG0047	phosphoribosylformylglycinamidine synthase activity
AOT14_RS14860	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AOT14_RS14870	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AOT14_RS14875	COG4974	Belongs to the 'phage' integrase family
AOT14_RS14885	COG0795	lipopolysaccharide-transporting ATPase activity
AOT14_RS14895	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AOT14_RS14910	COG0525	valine-tRNA ligase activity
AOT14_RS14920	COG0456	acetyltransferase
AOT14_RS14930	COG1183	phosphatidylcholine synthase activity
AOT14_RS14940	COG0442	prolyl-tRNA aminoacylation
AOT14_RS14955	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AOT14_RS14960	COG1127	ABC transporter
AOT14_RS14965	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AOT14_RS14965	COG3218	ABC-type transport auxiliary lipoprotein component
AOT14_RS14980	COG0024	Methionine aminopeptidase
AOT14_RS14995	COG3214	Protein conserved in bacteria
AOT14_RS15015	COG0823	Involved in the tonB-independent uptake of proteins
AOT14_RS15015	COG1506	peptidase
AOT14_RS15020	COG4206	TonB-dependent receptor
AOT14_RS15050	COG3550	peptidyl-serine autophosphorylation
AOT14_RS15060	COG3039	Transposase
AOT14_RS15095	COG2375	cellular response to nickel ion
AOT14_RS15140	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AOT14_RS15175	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AOT14_RS15185	COG0459	protein refolding
AOT14_RS15190	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AOT14_RS15195	COG1324	tolerance protein
AOT14_RS15205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AOT14_RS15210	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AOT14_RS15215	COG0511	ligase activity, forming carbon-carbon bonds
AOT14_RS15220	COG0439	Biotin carboxylase
AOT14_RS15225	COG2264	protein methyltransferase activity
AOT14_RS15235	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AOT14_RS15240	COG0138	bifunctional purine biosynthesis protein purh
AOT14_RS15255	COG0151	Belongs to the GarS family
AOT14_RS15260	COG0667	Aldo Keto reductase
AOT14_RS15270	COG1289	transmembrane transporter activity
AOT14_RS15275	COG2814	Major facilitator Superfamily
AOT14_RS15285	COG2814	Major facilitator Superfamily
AOT14_RS15305	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AOT14_RS15340	COG5002	protein histidine kinase activity
AOT14_RS15340	COG2205	protein histidine kinase activity
AOT14_RS15340	COG0784	Response regulator, receiver
AOT14_RS15355	COG1051	belongs to the nudix hydrolase family
AOT14_RS15375	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AOT14_RS15380	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AOT14_RS15385	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AOT14_RS15395	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AOT14_RS15400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AOT14_RS15405	COG0730	response to heat
AOT14_RS15415	COG0134	indole-3-glycerol-phosphate synthase activity
AOT14_RS15420	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AOT14_RS15430	COG0512	Glutamine amidotransferase of anthranilate synthase
AOT14_RS15435	COG3039	Transposase
AOT14_RS15485	COG0629	single-stranded DNA binding
AOT14_RS15490	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AOT14_RS15680	COG2003	Belongs to the UPF0758 family
AOT14_RS15760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOT14_RS15765	COG1129	ABC transporter
AOT14_RS15765	COG0842	Transport permease protein
AOT14_RS15770	COG0842	Transport permease protein
AOT14_RS15780	COG1028	Short-chain dehydrogenase reductase Sdr
AOT14_RS15800	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AOT14_RS15805	COG0786	glutamate:sodium symporter activity
AOT14_RS15810	COG3243	poly(R)-hydroxyalkanoic acid synthase
AOT14_RS15815	COG0589	response to stress
AOT14_RS15835	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AOT14_RS15845	COG0583	DNA-binding transcription factor activity
AOT14_RS15850	COG1396	sequence-specific DNA binding
AOT14_RS15860	COG0582	viral genome integration into host DNA
AOT14_RS15875	COG2205	protein histidine kinase activity
AOT14_RS15900	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AOT14_RS15905	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AOT14_RS15910	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AOT14_RS15925	COG2111	Na H antiporter
AOT14_RS15925	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AOT14_RS15930	COG1006	Multisubunit Na H antiporter MnhC subunit
AOT14_RS15935	COG0651	ATP synthesis coupled electron transport
AOT14_RS15945	COG2212	antiporter activity
AOT14_RS15950	COG1320	monovalent cation:proton antiporter activity
AOT14_RS15985	COG3104	oligopeptide transport
AOT14_RS15990	COG3483	tryptophan 2,3-dioxygenase activity
AOT14_RS15995	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AOT14_RS16010	COG0508	dehydrogenase complex catalyzes the overall conversion of
AOT14_RS16035	COG0702	epimerase
AOT14_RS16040	COG3706	GGDEF domain
AOT14_RS16045	COG0612	Peptidase, M16
AOT14_RS16060	COG2354	Protein conserved in bacteria
AOT14_RS16070	COG1368	sulfuric ester hydrolase activity
AOT14_RS16075	COG1196	nuclear chromosome segregation
AOT14_RS16075	COG3264	Mechanosensitive ion channel
AOT14_RS16090	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AOT14_RS16105	COG4807	Protein conserved in bacteria
AOT14_RS16115	COG0789	Transcriptional regulator
AOT14_RS16165	COG0596	Alpha beta hydrolase
AOT14_RS16195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AOT14_RS16215	COG0628	permease
AOT14_RS16225	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AOT14_RS16230	COG0753	catalase activity
AOT14_RS16240	COG2197	response regulator
AOT14_RS16245	COG4585	Histidine kinase
AOT14_RS16250	COG0842	Transport permease protein
AOT14_RS16255	COG1131	(ABC) transporter
AOT14_RS16260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOT14_RS16265	COG1136	(ABC) transporter
AOT14_RS16275	COG0577	efflux transmembrane transporter activity
AOT14_RS16275	COG1136	(ABC) transporter
AOT14_RS16290	COG2962	Rard protein
AOT14_RS16295	COG0697	spore germination
AOT14_RS16315	COG0180	Tryptophanyl-tRNA synthetase
AOT14_RS16325	COG3237	CsbD-like
AOT14_RS16340	COG0010	Belongs to the arginase family
AOT14_RS16395	COG3038	cytochrome b561
AOT14_RS16405	COG2203	Gaf domain
AOT14_RS16405	COG5001	Diguanylate cyclase
AOT14_RS16405	COG4251	negative regulation of phosphorylation
AOT14_RS16405	COG3706	GGDEF domain
AOT14_RS16415	COG4774	siderophore transport
AOT14_RS16430	COG3655	Transcriptional regulator
AOT14_RS16435	COG1506	peptidase
AOT14_RS16440	COG0784	Response regulator, receiver
AOT14_RS16440	COG2205	protein histidine kinase activity
AOT14_RS16450	COG0784	Response regulator, receiver
AOT14_RS16450	COG2205	protein histidine kinase activity
AOT14_RS16455	COG2197	response regulator
AOT14_RS16470	COG4695	Portal protein
AOT14_RS16690	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AOT14_RS16695	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AOT14_RS16695	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AOT14_RS16725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AOT14_RS16730	COG3209	COG3209 Rhs family protein
AOT14_RS16740	COG2076	Multidrug Resistance protein
AOT14_RS16785	COG1285	pathogenesis
AOT14_RS16790	COG1335	isochorismatase
AOT14_RS16800	COG1902	pentaerythritol trinitrate reductase activity
AOT14_RS16815	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AOT14_RS16840	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AOT14_RS16850	COG0697	spore germination
AOT14_RS16875	COG1960	acyl-CoA dehydrogenase activity
AOT14_RS16880	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AOT14_RS16915	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AOT14_RS16920	COG0583	DNA-binding transcription factor activity
AOT14_RS16930	COG0277	FAD linked oxidase domain protein
AOT14_RS16935	COG1304	FMN binding
AOT14_RS16940	COG2186	Transcriptional regulator
AOT14_RS16950	COG3279	Response regulator of the LytR AlgR family
AOT14_RS16965	COG0681	Belongs to the peptidase S26 family
AOT14_RS16980	COG0339	signal peptide processing
AOT14_RS16985	COG0415	Belongs to the DNA photolyase family
AOT14_RS17025	COG3039	Transposase
AOT14_RS17040	COG0564	pseudouridine synthase activity
AOT14_RS17060	COG1181	Belongs to the D-alanine--D-alanine ligase family
AOT14_RS17070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AOT14_RS17075	COG0318	PFAM AMP-dependent synthetase and ligase
AOT14_RS17085	COG0596	Alpha beta hydrolase
AOT14_RS17090	COG1573	uracil-dna glycosylase
AOT14_RS17095	COG3012	SEC-C Motif Domain Protein
AOT14_RS17095	COG3318	Belongs to the UPF0149 family
AOT14_RS17100	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AOT14_RS17110	COG0612	Peptidase, M16
AOT14_RS17120	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AOT14_RS17130	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AOT14_RS17135	COG1960	acyl-CoA dehydrogenase activity
AOT14_RS17140	COG1113	amino acid transport
AOT14_RS17150	COG1199	ATP-dependent helicase activity
AOT14_RS17160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AOT14_RS17180	COG3781	membrane
AOT14_RS17215	COG3039	Transposase
AOT14_RS17220	COG3209	COG3209 Rhs family protein
AOT14_RS17230	COG0625	glutathione transferase activity
AOT14_RS17245	COG1668	transmembrane transport
AOT14_RS17250	COG4555	ABC transporter
AOT14_RS17280	COG1131	(ABC) transporter
AOT14_RS17285	COG0842	Transport permease protein
AOT14_RS17290	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AOT14_RS17305	COG0084	hydrolase, TatD family'
AOT14_RS17310	COG1643	Atp-dependent helicase
AOT14_RS17320	COG1187	pseudouridine synthase activity
AOT14_RS17345	COG2239	Acts as a magnesium transporter
AOT14_RS17350	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AOT14_RS17350	COG0475	glutathione-regulated potassium exporter activity
AOT14_RS17365	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AOT14_RS17375	COG0463	Glycosyl transferase, family 2
AOT14_RS17380	COG1028	Short-chain dehydrogenase reductase Sdr
AOT14_RS17385	COG2365	Tyrosine phosphatase family
AOT14_RS17390	COG4771	TonB-dependent receptor
AOT14_RS17420	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AOT14_RS17435	COG0251	oxidation-reduction process
AOT14_RS17460	COG0408	coproporphyrinogen oxidase activity
AOT14_RS17465	COG2323	membrane
AOT14_RS17480	COG0589	response to stress
AOT14_RS17485	COG0210	DNA helicase
AOT14_RS17495	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AOT14_RS17500	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AOT14_RS17545	COG4771	TonB-dependent receptor
AOT14_RS17550	COG1429	ligase activity, forming nitrogen-metal bonds
AOT14_RS17570	COG0463	Glycosyl transferase, family 2
AOT14_RS17585	COG1475	DNA binding
AOT14_RS17590	COG1192	Involved in chromosome partitioning
AOT14_RS17595	COG0357	Ribosomal RNA small subunit methyltransferase G
AOT14_RS17600	COG2091	lysine biosynthetic process via aminoadipic acid
AOT14_RS17615	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AOT14_RS17620	COG4149	molybdate abc transporter
AOT14_RS17625	COG0725	ABC transporter, periplasmic molybdate-binding protein
AOT14_RS17635	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AOT14_RS17640	COG2181	nitrate reductase activity
AOT14_RS17645	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
AOT14_RS17650	COG1140	nitrate reductase beta subunit
AOT14_RS17655	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
AOT14_RS17660	COG2223	nitrite transmembrane transporter activity
AOT14_RS17670	COG0746	molybdenum cofactor guanylyltransferase activity
AOT14_RS17675	COG0314	molybdopterin synthase activity
AOT14_RS17685	COG0303	'Molybdopterin
AOT14_RS17690	COG0521	Mo-molybdopterin cofactor biosynthetic process
AOT14_RS17690	COG0315	cyclic pyranopterin monophosphate synthase activity
AOT14_RS17695	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AOT14_RS17715	COG4771	TonB-dependent receptor
AOT14_RS17725	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AOT14_RS17730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AOT14_RS17735	COG1120	ATPase activity
AOT14_RS17740	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AOT14_RS17750	COG3162	membrane
AOT14_RS17770	COG0840	transmembrane signaling receptor activity
AOT14_RS17775	COG1971	Probably functions as a manganese efflux pump
AOT14_RS17835	COG0729	surface antigen
AOT14_RS17855	COG0752	glycyl-tRNA synthetase alpha subunit
AOT14_RS17860	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AOT14_RS17865	COG0519	Catalyzes the synthesis of GMP from XMP
AOT14_RS17865	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AOT14_RS17875	COG0805	protein transport
AOT14_RS17895	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AOT14_RS17900	COG2267	carboxylic ester hydrolase activity
AOT14_RS17910	COG2974	May be involved in recombination
AOT14_RS17915	COG0037	tRNA processing
AOT14_RS17940	COG2937	Belongs to the GPAT DAPAT family
AOT14_RS17950	COG0284	orotidine-5'-phosphate decarboxylase activity
AOT14_RS17955	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
AOT14_RS17960	COG3132	Protein of unknown function, DUF480
AOT14_RS17965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AOT14_RS17970	COG0210	DNA helicase
AOT14_RS17985	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AOT14_RS17990	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AOT14_RS18020	COG0840	transmembrane signaling receptor activity
AOT14_RS18035	COG1752	Esterase of the alpha-beta hydrolase superfamily
AOT14_RS18055	COG1429	ligase activity, forming nitrogen-metal bonds
AOT14_RS18060	COG4771	TonB-dependent receptor
AOT14_RS18070	COG3186	Phenylalanine-4-hydroxylase
AOT14_RS18085	COG2197	response regulator
AOT14_RS18135	COG1741	Belongs to the pirin family
AOT14_RS18140	COG0583	DNA-binding transcription factor activity
AOT14_RS18145	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AOT14_RS18150	COG1074	ATP-dependent DNA helicase activity
AOT14_RS18155	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AOT14_RS18160	COG1127	ABC transporter
AOT14_RS18165	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AOT14_RS18170	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AOT14_RS18185	COG2853	Lipoprotein
AOT14_RS18195	COG0386	Belongs to the glutathione peroxidase family
AOT14_RS18220	COG0531	amino acid
AOT14_RS18230	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AOT14_RS18235	COG0861	Integral membrane protein TerC family
AOT14_RS18245	COG0584	glycerophosphoryl diester phosphodiesterase
AOT14_RS18250	COG0488	(ABC) transporter
AOT14_RS18265	COG0706	membrane insertase activity
AOT14_RS18270	COG0594	ribonuclease P activity
AOT14_RS18275	COG0230	Belongs to the bacterial ribosomal protein bL34 family