locus-tag	class	description
NDK23_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NDK23_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NDK23_RS00020	COG0187	DNA topoisomerase II activity
NDK23_RS00025	COG1266	CAAX protease self-immunity
NDK23_RS00030	COG0501	Belongs to the peptidase M48B family
NDK23_RS00105	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
NDK23_RS00135	COG0659	secondary active sulfate transmembrane transporter activity
NDK23_RS00150	COG0492	ferredoxin-NADP+ reductase activity
NDK23_RS00155	COG0798	PFAM Bile acid sodium symporter
NDK23_RS00170	COG0431	NADPH-dependent FMN reductase
NDK23_RS00175	COG1393	Belongs to the ArsC family
NDK23_RS00215	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
NDK23_RS00225	COG4772	TonB-dependent receptor
NDK23_RS00260	COG0800	Aldolase
NDK23_RS00280	COG3186	Phenylalanine-4-hydroxylase
NDK23_RS00285	COG1522	sequence-specific DNA binding
NDK23_RS00295	COG1752	Esterase of the alpha-beta hydrolase superfamily
NDK23_RS00305	COG4771	TonB-dependent receptor
NDK23_RS00325	COG1119	ATPase activity
NDK23_RS00340	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NDK23_RS00345	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
NDK23_RS00365	COG0210	DNA helicase
NDK23_RS00375	COG3132	Protein of unknown function, DUF480
NDK23_RS00380	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
NDK23_RS00385	COG0284	orotidine-5'-phosphate decarboxylase activity
NDK23_RS00395	COG2937	Belongs to the GPAT DAPAT family
NDK23_RS00405	COG0037	tRNA processing
NDK23_RS00410	COG2974	May be involved in recombination
NDK23_RS00420	COG1803	Methylglyoxal synthase
NDK23_RS00425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NDK23_RS00425	COG2205	protein histidine kinase activity
NDK23_RS00430	COG0493	'glutamate synthase
NDK23_RS00435	COG0070	glutamate synthase
NDK23_RS00435	COG0067	glutamate synthase
NDK23_RS00435	COG0069	glutamate synthase activity
NDK23_RS00455	COG1028	Short-chain dehydrogenase reductase Sdr
NDK23_RS00470	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NDK23_RS00495	COG1205	dead DEAH box helicase
NDK23_RS00495	COG1111	helicase
NDK23_RS00530	COG0714	Associated with various cellular activities
NDK23_RS00550	COG0312	modulator of DNA gyrase
NDK23_RS00560	COG3550	peptidyl-serine autophosphorylation
NDK23_RS00580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NDK23_RS00600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NDK23_RS00625	COG1881	PFAM PEBP family protein
NDK23_RS00640	COG1968	undecaprenyl-diphosphatase activity
NDK23_RS00645	COG0174	glutamine synthetase
NDK23_RS00650	COG0347	Belongs to the P(II) protein family
NDK23_RS00655	COG0004	ammonium transporteR
NDK23_RS00660	COG3023	N-Acetylmuramoyl-L-alanine amidase
NDK23_RS00670	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
NDK23_RS00685	COG3852	Histidine kinase
NDK23_RS00690	COG2204	response regulator
NDK23_RS00695	COG2032	superoxide dismutase activity
NDK23_RS00700	COG2032	superoxide dismutase activity
NDK23_RS00710	COG0183	Belongs to the thiolase family
NDK23_RS00745	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
NDK23_RS00750	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NDK23_RS00770	COG0798	PFAM Bile acid sodium symporter
NDK23_RS00785	COG0431	NADPH-dependent FMN reductase
NDK23_RS00935	COG2837	iron assimilation
NDK23_RS00980	COG2197	response regulator
NDK23_RS00985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NDK23_RS00985	COG2205	protein histidine kinase activity
NDK23_RS00990	COG3474	cytochrome
NDK23_RS01000	COG1960	acyl-CoA dehydrogenase activity
NDK23_RS01005	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NDK23_RS01015	COG0612	Peptidase, M16
NDK23_RS01025	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NDK23_RS01030	COG0596	Alpha beta hydrolase
NDK23_RS01040	COG0318	PFAM AMP-dependent synthetase and ligase
NDK23_RS01045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NDK23_RS01055	COG1181	Belongs to the D-alanine--D-alanine ligase family
NDK23_RS01065	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NDK23_RS01080	COG1215	transferase activity, transferring glycosyl groups
NDK23_RS01085	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NDK23_RS01115	COG0339	signal peptide processing
NDK23_RS01130	COG0681	Belongs to the peptidase S26 family
NDK23_RS01135	COG2814	Major facilitator Superfamily
NDK23_RS01140	COG2801	Transposase and inactivated derivatives
NDK23_RS01140	COG3415	Transposase
NDK23_RS01145	COG0583	DNA-binding transcription factor activity
NDK23_RS01150	COG0583	DNA-binding transcription factor activity
NDK23_RS01155	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NDK23_RS01160	COG2224	Isocitrate lyase
NDK23_RS01165	COG3706	GGDEF domain
NDK23_RS01190	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NDK23_RS01195	COG1960	acyl-CoA dehydrogenase activity
NDK23_RS01220	COG0697	spore germination
NDK23_RS01230	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
NDK23_RS01240	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NDK23_RS01250	COG1280	lysine exporter protein (LysE YggA)
NDK23_RS01255	COG1607	acyl-coa hydrolase
NDK23_RS01265	COG1902	pentaerythritol trinitrate reductase activity
NDK23_RS01280	COG1335	isochorismatase
NDK23_RS01285	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NDK23_RS01295	COG1051	belongs to the nudix hydrolase family
NDK23_RS01295	COG1056	cytidyltransferase-related domain
NDK23_RS01300	COG1752	Esterase of the alpha-beta hydrolase superfamily
NDK23_RS01310	COG1396	sequence-specific DNA binding
NDK23_RS01310	COG3800	Transcriptional regulator
NDK23_RS01320	COG1960	acyl-CoA dehydrogenase activity
NDK23_RS01325	COG1024	Enoyl-CoA hydratase
NDK23_RS01330	COG1024	Enoyl-CoA hydratase
NDK23_RS01340	COG1764	response to oxidative stress
NDK23_RS01365	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NDK23_RS01395	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NDK23_RS01395	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NDK23_RS01400	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NDK23_RS01425	COG3657	addiction module killer protein
NDK23_RS01465	COG3237	CsbD-like
NDK23_RS01475	COG0180	Tryptophanyl-tRNA synthetase
NDK23_RS01500	COG0477	Major facilitator Superfamily
NDK23_RS01505	COG0697	spore germination
NDK23_RS01515	COG4206	TonB-dependent receptor
NDK23_RS01520	COG1136	(ABC) transporter
NDK23_RS01520	COG0577	efflux transmembrane transporter activity
NDK23_RS01530	COG1136	(ABC) transporter
NDK23_RS01550	COG4585	Histidine kinase
NDK23_RS01555	COG2197	response regulator
NDK23_RS01570	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NDK23_RS01580	COG0628	permease
NDK23_RS01600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NDK23_RS01615	COG5507	3-demethylubiquinone-9 3-methyltransferase
NDK23_RS01630	COG2197	response regulator
NDK23_RS01645	COG2814	Major facilitator Superfamily
NDK23_RS01650	COG0583	DNA-binding transcription factor activity
NDK23_RS01655	COG4807	Protein conserved in bacteria
NDK23_RS01665	COG4221	oxidoreductase activity
NDK23_RS01675	COG0018	arginyl-trna synthetase
NDK23_RS01680	COG2003	Belongs to the UPF0758 family
NDK23_RS01685	COG2197	response regulator
NDK23_RS01690	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NDK23_RS01710	COG2205	protein histidine kinase activity
NDK23_RS01720	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
NDK23_RS01725	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
NDK23_RS01740	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NDK23_RS01745	COG0708	Exodeoxyribonuclease III
NDK23_RS01750	COG2223	nitrite transmembrane transporter activity
NDK23_RS01765	COG0739	heme binding
NDK23_RS01770	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NDK23_RS01830	COG2234	aminopeptidase activity
NDK23_RS01840	COG4942	peptidase
NDK23_RS01845	COG0793	Belongs to the peptidase S41A family
NDK23_RS01880	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NDK23_RS01925	COG0109	protoheme IX farnesyltransferase activity
NDK23_RS01945	COG0358	DNA primase activity
NDK23_RS01950	COG1295	ribonuclease BN
NDK23_RS01965	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NDK23_RS01975	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NDK23_RS01980	COG0668	transmembrane transport
NDK23_RS01995	COG2133	pyrroloquinoline quinone binding
NDK23_RS02000	COG4682	membrane
NDK23_RS02010	COG0531	amino acid
NDK23_RS02020	COG1737	Transcriptional regulator
NDK23_RS02025	COG4948	Mandelate Racemase Muconate Lactonizing
NDK23_RS02075	COG5383	Protein conserved in bacteria
NDK23_RS02085	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
NDK23_RS02090	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
NDK23_RS02120	COG0778	Nitroreductase
NDK23_RS02125	COG2353	YceI-like domain
NDK23_RS02140	COG2375	cellular response to nickel ion
NDK23_RS02225	COG2267	carboxylic ester hydrolase activity
NDK23_RS02285	COG2801	Transposase and inactivated derivatives
NDK23_RS02285	COG3415	Transposase
NDK23_RS02300	COG0488	(ABC) transporter
NDK23_RS02305	COG0583	DNA-binding transcription factor activity
NDK23_RS02315	COG2814	Major facilitator Superfamily
NDK23_RS02320	COG4943	cyclic-guanylate-specific phosphodiesterase activity
NDK23_RS02325	COG1113	amino acid transport
NDK23_RS02330	COG0741	lytic transglycosylase activity
NDK23_RS02355	COG2764	glyoxalase bleomycin resistance protein dioxygenase
NDK23_RS02365	COG5507	3-demethylubiquinone-9 3-methyltransferase
NDK23_RS02370	COG4941	Belongs to the sigma-70 factor family
NDK23_RS02400	COG3275	phosphorelay sensor kinase activity
NDK23_RS02405	COG3279	Response regulator of the LytR AlgR family
NDK23_RS02425	COG1309	transcriptional regulator
NDK23_RS02440	COG3590	peptidase
NDK23_RS02445	COG5001	Diguanylate cyclase
NDK23_RS02450	COG0583	DNA-binding transcription factor activity
NDK23_RS02460	COG3384	dioxygenase
NDK23_RS02465	COG0025	NhaP-type Na H and K H
NDK23_RS02490	COG1360	Flagellar Motor Protein
NDK23_RS02520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NDK23_RS02535	COG5002	protein histidine kinase activity
NDK23_RS02550	COG2813	Specifically methylates the guanine in position
NDK23_RS02555	COG1187	pseudouridine synthase activity
NDK23_RS02560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NDK23_RS02570	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NDK23_RS02575	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NDK23_RS02590	COG0583	DNA-binding transcription factor activity
NDK23_RS02595	COG2226	methyltransferase
NDK23_RS02620	COG1956	GAF domain-containing protein
NDK23_RS02625	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NDK23_RS02630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NDK23_RS02635	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NDK23_RS02640	COG0785	Cytochrome C biogenesis protein
NDK23_RS02640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NDK23_RS02645	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NDK23_RS02650	COG0745	RESPONSE REGULATOR receiver
NDK23_RS02655	COG2205	protein histidine kinase activity
NDK23_RS02660	COG2205	protein histidine kinase activity
NDK23_RS02665	COG0745	RESPONSE REGULATOR receiver
NDK23_RS02670	COG0367	asparagine synthase
NDK23_RS02680	COG0720	synthase
NDK23_RS02695	COG0513	Belongs to the DEAD box helicase family
NDK23_RS02705	COG0625	glutathione transferase activity
NDK23_RS02745	COG0626	cystathionine gamma-synthase activity
NDK23_RS02770	COG1215	transferase activity, transferring glycosyl groups
NDK23_RS02785	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NDK23_RS02810	COG0300	oxidoreductase activity
NDK23_RS02815	COG0277	FAD linked oxidase domain protein
NDK23_RS02820	COG0546	phosphoglycolate phosphatase activity
NDK23_RS02820	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NDK23_RS02860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NDK23_RS02865	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NDK23_RS02875	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NDK23_RS02900	COG1127	ABC transporter
NDK23_RS02905	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NDK23_RS02920	COG0442	prolyl-tRNA aminoacylation
NDK23_RS02930	COG1183	phosphatidylcholine synthase activity
NDK23_RS02940	COG0456	acetyltransferase
NDK23_RS02950	COG0525	valine-tRNA ligase activity
NDK23_RS02960	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NDK23_RS02970	COG0795	lipopolysaccharide-transporting ATPase activity
NDK23_RS02980	COG4974	Belongs to the 'phage' integrase family
NDK23_RS02985	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NDK23_RS02995	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NDK23_RS02995	COG0047	phosphoribosylformylglycinamidine synthase activity
NDK23_RS03000	COG5295	Hep Hag repeat protein
NDK23_RS03005	COG1404	Belongs to the peptidase S8 family
NDK23_RS03010	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NDK23_RS03015	COG1459	type II secretion system
NDK23_RS03020	COG2165	general secretion pathway protein
NDK23_RS03025	COG4970	Tfp pilus assembly protein FimT
NDK23_RS03030	COG2165	general secretion pathway protein
NDK23_RS03035	COG4795	General secretion pathway protein
NDK23_RS03040	COG3156	type II secretion system protein K
NDK23_RS03045	COG3166	PFAM Fimbrial assembly family protein
NDK23_RS03060	COG1450	Type ii and iii secretion system protein
NDK23_RS03070	COG0463	Glycosyl transferase, family 2
NDK23_RS03075	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NDK23_RS03085	COG3539	Fimbrial protein
NDK23_RS03105	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NDK23_RS03115	COG1215	transferase activity, transferring glycosyl groups
NDK23_RS03130	COG2252	PERMEase
NDK23_RS03135	COG0488	(ABC) transporter
NDK23_RS03145	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NDK23_RS03165	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NDK23_RS03170	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NDK23_RS03170	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NDK23_RS03205	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NDK23_RS03210	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NDK23_RS03220	COG3121	Chaperone
NDK23_RS03235	COG3188	usher protein
NDK23_RS03245	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NDK23_RS03245	COG2755	lipolytic protein G-D-S-L family
NDK23_RS03250	COG0277	FAD linked oxidase domain protein
NDK23_RS03255	COG1988	membrane-bound metal-dependent
NDK23_RS03290	COG2001	Belongs to the MraZ family
NDK23_RS03295	COG0275	rRNA processing
NDK23_RS03300	COG3116	cell division
NDK23_RS03310	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NDK23_RS03315	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NDK23_RS03335	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NDK23_RS03340	COG1181	Belongs to the D-alanine--D-alanine ligase family
NDK23_RS03345	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NDK23_RS03355	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NDK23_RS03360	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
NDK23_RS03370	COG0739	heme binding
NDK23_RS03375	COG0653	protein targeting
NDK23_RS03380	COG0494	nUDIX hydrolase
NDK23_RS03390	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NDK23_RS03400	COG3275	phosphorelay sensor kinase activity
NDK23_RS03405	COG3279	Response regulator of the LytR AlgR family
NDK23_RS03425	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NDK23_RS03430	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NDK23_RS03440	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NDK23_RS03445	COG1607	acyl-coa hydrolase
NDK23_RS03450	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NDK23_RS03480	COG4106	trans-aconitate 2-methyltransferase activity
NDK23_RS03485	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NDK23_RS03505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NDK23_RS03510	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NDK23_RS03515	COG0667	Aldo Keto reductase
NDK23_RS03525	COG4771	TonB-dependent receptor
NDK23_RS03540	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
NDK23_RS03545	COG4181	ATPase activity
NDK23_RS03560	COG0642	Histidine kinase
NDK23_RS03570	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NDK23_RS03575	COG0861	Integral membrane protein TerC family
NDK23_RS03580	COG2814	Major facilitator Superfamily
NDK23_RS03585	COG1704	LemA family
NDK23_RS03600	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NDK23_RS03605	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NDK23_RS03615	COG3738	Protein conserved in bacteria
NDK23_RS03620	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NDK23_RS03625	COG2967	ApaG domain
NDK23_RS03630	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NDK23_RS03635	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NDK23_RS03640	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NDK23_RS03645	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
NDK23_RS03655	COG2096	Adenosyltransferase
NDK23_RS03665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NDK23_RS03670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NDK23_RS03675	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NDK23_RS03680	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
NDK23_RS03705	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NDK23_RS03715	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NDK23_RS03725	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NDK23_RS03730	COG0583	DNA-binding transcription factor activity
NDK23_RS03735	COG3634	alkyl hydroperoxide reductase activity
NDK23_RS03775	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NDK23_RS03775	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NDK23_RS03790	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
NDK23_RS03815	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
NDK23_RS03830	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NDK23_RS03835	COG1404	Belongs to the peptidase S8 family
NDK23_RS03855	COG1295	ribonuclease BN
NDK23_RS03860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NDK23_RS03875	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NDK23_RS03880	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NDK23_RS03895	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NDK23_RS03905	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NDK23_RS03910	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NDK23_RS03915	COG0193	aminoacyl-tRNA hydrolase activity
NDK23_RS03920	COG0012	GTP binding
NDK23_RS03925	COG4206	TonB-dependent receptor
NDK23_RS03930	COG4242	Belongs to the peptidase S51 family
NDK23_RS03955	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NDK23_RS03970	COG0250	Participates in transcription elongation, termination and antitermination
NDK23_RS03975	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NDK23_RS03980	COG0081	regulation of translation
NDK23_RS03985	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NDK23_RS03990	COG0222	ribosome binding
NDK23_RS03995	COG0085	RNA polymerase activity
NDK23_RS04000	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NDK23_RS04005	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NDK23_RS04010	COG0049	tRNA binding
NDK23_RS04015	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NDK23_RS04020	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NDK23_RS04025	COG0051	transcription antitermination factor activity, RNA binding
NDK23_RS04030	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NDK23_RS04035	COG0088	Forms part of the polypeptide exit tunnel
NDK23_RS04040	COG0089	rRNA binding
NDK23_RS04045	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NDK23_RS04050	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NDK23_RS04055	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NDK23_RS04060	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NDK23_RS04065	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NDK23_RS04070	COG0255	Belongs to the universal ribosomal protein uL29 family
NDK23_RS04075	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NDK23_RS04080	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NDK23_RS04085	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NDK23_RS04090	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NDK23_RS04095	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NDK23_RS04100	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NDK23_RS04105	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NDK23_RS04110	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NDK23_RS04115	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NDK23_RS04120	COG1841	ribosomal large subunit assembly
NDK23_RS04125	COG0200	Binds to the 23S rRNA
NDK23_RS04130	COG0201	protein transport
NDK23_RS04135	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NDK23_RS04140	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NDK23_RS04145	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NDK23_RS04150	COG0202	RNA polymerase activity
NDK23_RS04155	COG0203	ribosomal protein L17
NDK23_RS04170	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
NDK23_RS04180	COG0154	amidase activity
NDK23_RS04195	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NDK23_RS04200	COG0039	L-malate dehydrogenase activity
NDK23_RS04205	COG0564	pseudouridine synthase activity
NDK23_RS04215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NDK23_RS04230	COG0625	glutathione transferase activity
NDK23_RS04240	COG1902	pentaerythritol trinitrate reductase activity
NDK23_RS04240	COG0446	pyridine nucleotide-disulphide oxidoreductase
NDK23_RS04245	COG2364	Membrane
NDK23_RS04250	COG0604	alcohol dehydrogenase
NDK23_RS04265	COG1187	pseudouridine synthase activity
NDK23_RS04285	COG1063	alcohol dehydrogenase
NDK23_RS04295	COG0406	alpha-ribazole phosphatase activity
NDK23_RS04300	COG0285	dihydrofolate synthase activity
NDK23_RS04320	COG2833	Protein of unknown function (DUF455)
NDK23_RS04330	COG3291	Pkd domain containing protein
NDK23_RS04335	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NDK23_RS04345	COG0438	transferase activity, transferring glycosyl groups
NDK23_RS04360	COG0248	Ppx GppA phosphatase
NDK23_RS04365	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NDK23_RS04380	COG4783	chaperone-mediated protein folding
NDK23_RS04395	COG0473	3-isopropylmalate dehydrogenase activity
NDK23_RS04455	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
NDK23_RS04495	COG0592	DNA-directed DNA polymerase activity
NDK23_RS04520	COG2204	response regulator
NDK23_RS04680	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NDK23_RS04680	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NDK23_RS04745	COG0544	peptidyl-prolyl cis-trans isomerase activity
NDK23_RS04750	COG0740	serine-type endopeptidase activity
NDK23_RS04755	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NDK23_RS04795	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NDK23_RS04800	COG3942	CHAP domain
NDK23_RS04800	COG1388	LysM domain
NDK23_RS04805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NDK23_RS04815	COG0328	RNA-DNA hybrid ribonuclease activity
NDK23_RS04820	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NDK23_RS04825	COG0631	protein serine/threonine phosphatase activity
NDK23_RS04845	COG0859	PFAM glycosyl transferase family 9
NDK23_RS04850	COG3642	lipopolysaccharide core region biosynthetic process
NDK23_RS04855	COG1234	tRNA 3'-trailer cleavage
NDK23_RS04870	COG2076	Multidrug Resistance protein
NDK23_RS04895	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NDK23_RS04990	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NDK23_RS05000	COG0537	adenosine 5'-monophosphoramidase activity
NDK23_RS05020	COG0714	Associated with various cellular activities
NDK23_RS05030	COG3415	Transposase
NDK23_RS05030	COG2801	Transposase and inactivated derivatives
NDK23_RS05040	COG1399	metal-binding, possibly nucleic acid-binding protein
NDK23_RS05045	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NDK23_RS05050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NDK23_RS05060	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NDK23_RS05065	COG1028	Short-chain dehydrogenase reductase Sdr
NDK23_RS05075	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NDK23_RS05080	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NDK23_RS05085	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NDK23_RS05090	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NDK23_RS05245	COG4774	siderophore transport
NDK23_RS05255	COG2223	nitrite transmembrane transporter activity
NDK23_RS05270	COG2226	methyltransferase
NDK23_RS05280	COG0583	DNA-binding transcription factor activity
NDK23_RS05285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NDK23_RS05290	COG0697	spore germination
NDK23_RS05300	COG0477	Major facilitator Superfamily
NDK23_RS05335	COG0583	DNA-binding transcription factor activity
NDK23_RS05345	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NDK23_RS05360	COG2801	Transposase and inactivated derivatives
NDK23_RS05360	COG3415	Transposase
NDK23_RS05365	COG0667	Aldo Keto reductase
NDK23_RS05390	COG0519	Catalyzes the synthesis of GMP from XMP
NDK23_RS05395	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
NDK23_RS05400	COG1678	Uncharacterized ACR, COG1678
NDK23_RS05405	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NDK23_RS05410	COG0540	Belongs to the ATCase OTCase family
NDK23_RS05430	COG2239	Acts as a magnesium transporter
NDK23_RS05435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NDK23_RS05450	COG1660	Displays ATPase and GTPase activities
NDK23_RS05455	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
NDK23_RS05460	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NDK23_RS05465	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NDK23_RS05475	COG1137	ATPase activity
NDK23_RS05490	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
NDK23_RS05505	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NDK23_RS05525	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NDK23_RS05545	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NDK23_RS05555	COG0628	permease
NDK23_RS05565	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NDK23_RS05575	COG2261	transglycosylase associated protein
NDK23_RS05585	COG1555	photosystem II stabilization
NDK23_RS05605	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NDK23_RS05610	COG1477	protein flavinylation
NDK23_RS05630	COG4771	TonB-dependent receptor
NDK23_RS05635	COG4771	TonB-dependent receptor
NDK23_RS05645	COG3128	pkhd-type hydroxylase
NDK23_RS05655	COG4774	siderophore transport
NDK23_RS05665	COG2146	nitrite reductase [NAD(P)H] activity
NDK23_RS05680	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NDK23_RS05685	COG0719	Fe-S assembly protein
NDK23_RS05690	COG0396	ATPase activity
NDK23_RS05700	COG0719	Fe-S assembly protein
NDK23_RS05705	COG1959	2 iron, 2 sulfur cluster binding
NDK23_RS05715	COG0693	protein deglycase activity
NDK23_RS05740	COG1764	response to oxidative stress
NDK23_RS05745	COG0384	phenazine biosynthesis protein PhzF
NDK23_RS05750	COG0384	phenazine biosynthesis protein PhzF
NDK23_RS05755	COG0527	aspartate kinase activity
NDK23_RS05765	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NDK23_RS05780	COG0142	geranyltranstransferase activity
NDK23_RS05785	COG0366	Alpha amylase catalytic
NDK23_RS05795	COG1082	Xylose isomerase domain protein TIM barrel
NDK23_RS05805	COG2190	(PTS) system
NDK23_RS05805	COG2211	Major facilitator Superfamily
NDK23_RS05840	COG1131	(ABC) transporter
NDK23_RS05850	COG0629	single-stranded DNA binding
NDK23_RS05885	COG0673	inositol 2-dehydrogenase activity
NDK23_RS05890	COG2211	Major facilitator Superfamily
NDK23_RS05900	COG1609	Transcriptional regulator
NDK23_RS05940	COG0640	Transcriptional regulator
NDK23_RS05955	COG3655	Transcriptional regulator
NDK23_RS05960	COG1253	flavin adenine dinucleotide binding
NDK23_RS05965	COG1408	metallophosphoesterase
NDK23_RS05970	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
NDK23_RS05990	COG2259	Doxx family
NDK23_RS06020	COG0477	Major facilitator Superfamily
NDK23_RS06035	COG1802	Transcriptional regulator
NDK23_RS06070	COG3052	prosthetic group binding
NDK23_RS06085	COG0579	oxidoreductase
NDK23_RS06110	COG3104	oligopeptide transport
NDK23_RS06125	COG1297	OPT oligopeptide transporter protein
NDK23_RS06130	COG0823	Involved in the tonB-independent uptake of proteins
NDK23_RS06130	COG1506	peptidase
NDK23_RS06145	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
NDK23_RS06150	COG2894	cell division
NDK23_RS06165	COG4585	Histidine kinase
NDK23_RS06170	COG2197	response regulator
NDK23_RS06210	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
NDK23_RS06220	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
NDK23_RS06230	COG1595	DNA-templated transcription, initiation
NDK23_RS06240	COG1946	Acyl-CoA thioesterase
NDK23_RS06260	COG0824	Thioesterase
NDK23_RS06265	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NDK23_RS06270	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NDK23_RS06275	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NDK23_RS06280	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NDK23_RS06285	COG0268	Binds directly to 16S ribosomal RNA
NDK23_RS06290	COG0728	peptidoglycan biosynthetic process
NDK23_RS06295	COG0196	riboflavin kinase activity
NDK23_RS06300	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NDK23_RS06310	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NDK23_RS06335	COG4206	TonB-dependent receptor
NDK23_RS06355	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NDK23_RS06365	COG3209	COG3209 Rhs family protein
NDK23_RS06395	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NDK23_RS06400	COG1845	cytochrome c oxidase, subunit III
NDK23_RS06405	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NDK23_RS06420	COG0326	Molecular chaperone. Has ATPase activity
NDK23_RS06440	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NDK23_RS06455	COG0228	four-way junction DNA binding
NDK23_RS06460	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NDK23_RS06465	COG0336	Belongs to the RNA methyltransferase TrmD family
NDK23_RS06470	COG0335	large ribosomal subunit rRNA binding
NDK23_RS06490	COG0534	Mate efflux family protein
NDK23_RS06510	COG0753	catalase activity
NDK23_RS06515	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NDK23_RS06610	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NDK23_RS06660	COG0840	transmembrane signaling receptor activity
NDK23_RS06680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NDK23_RS06700	COG4771	TonB-dependent receptor
NDK23_RS06705	COG0739	heme binding
NDK23_RS06715	COG0024	Methionine aminopeptidase
NDK23_RS06740	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NDK23_RS06765	COG1647	Serine aminopeptidase, S33
NDK23_RS06790	COG2814	Major facilitator Superfamily
NDK23_RS06795	COG3706	GGDEF domain
NDK23_RS06820	COG0588	phosphoglycerate mutase activity
NDK23_RS06825	COG3590	peptidase
NDK23_RS06835	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NDK23_RS06845	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
NDK23_RS06850	COG0745	RESPONSE REGULATOR receiver
NDK23_RS06855	COG2205	protein histidine kinase activity
NDK23_RS06860	COG4452	Inner membrane protein CreD
NDK23_RS06875	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NDK23_RS06880	COG0735	belongs to the Fur family
NDK23_RS06920	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NDK23_RS06960	COG5002	protein histidine kinase activity
NDK23_RS06960	COG5001	Diguanylate cyclase
NDK23_RS06970	COG1187	pseudouridine synthase activity
NDK23_RS06980	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NDK23_RS07005	COG1132	(ABC) transporter
NDK23_RS07055	COG1695	Transcriptional regulator
NDK23_RS07075	COG1981	membrane
NDK23_RS07080	COG0825	malonyl-CoA metabolic process
NDK23_RS07105	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NDK23_RS07115	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NDK23_RS07125	COG0750	zinc metalloprotease
NDK23_RS07130	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NDK23_RS07135	COG0575	Belongs to the CDS family
NDK23_RS07140	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NDK23_RS07145	COG0233	cytoplasmic translational termination
NDK23_RS07150	COG0528	UMP kinase activity
NDK23_RS07160	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NDK23_RS07165	COG0052	Belongs to the universal ribosomal protein uS2 family
NDK23_RS07185	COG3188	usher protein
NDK23_RS07205	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
NDK23_RS07220	COG1393	Belongs to the ArsC family
NDK23_RS07225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NDK23_RS07230	COG0367	asparagine synthase
NDK23_RS07235	COG0475	glutathione-regulated potassium exporter activity
NDK23_RS07270	COG1566	PFAM secretion protein HlyD family protein
NDK23_RS07275	COG2814	Major facilitator Superfamily
NDK23_RS07290	COG0583	DNA-binding transcription factor activity
NDK23_RS07310	COG0557	exoribonuclease II activity
NDK23_RS07320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NDK23_RS07325	COG1538	Outer membrane efflux protein
NDK23_RS07330	COG0577	efflux transmembrane transporter activity
NDK23_RS07330	COG1136	(ABC) transporter
NDK23_RS07335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NDK23_RS07355	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NDK23_RS07360	COG2259	Doxx family
NDK23_RS07370	COG3220	belongs to the UPF0276 family
NDK23_RS07380	COG0704	Plays a role in the regulation of phosphate uptake
NDK23_RS07390	COG0581	inorganic phosphate transmembrane transporter activity
NDK23_RS07395	COG0573	inorganic phosphate transmembrane transporter activity
NDK23_RS07400	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NDK23_RS07405	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NDK23_RS07415	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NDK23_RS07425	COG1024	Enoyl-CoA hydratase
NDK23_RS07435	COG0494	nUDIX hydrolase
NDK23_RS07455	COG0116	Belongs to the methyltransferase superfamily
NDK23_RS07455	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NDK23_RS07475	COG2733	membrane
NDK23_RS07485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NDK23_RS07490	COG1012	belongs to the aldehyde dehydrogenase family
NDK23_RS07500	COG0477	Major facilitator Superfamily
NDK23_RS07505	COG2703	oxygen carrier activity
NDK23_RS07525	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NDK23_RS07530	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
NDK23_RS07535	COG0174	glutamine synthetase
NDK23_RS07545	COG2072	flavoprotein involved in K transport
NDK23_RS07550	COG3842	ATPase activity
NDK23_RS07555	COG1176	ABC-type spermidine putrescine transport system, permease component I
NDK23_RS07560	COG1177	transmembrane transport
NDK23_RS07565	COG1012	belongs to the aldehyde dehydrogenase family
NDK23_RS07580	COG4535	Mg2 and Co2 transporter CorC
NDK23_RS07600	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NDK23_RS07605	COG1702	phosphate starvation-inducible protein PhoH
NDK23_RS07615	COG1131	(ABC) transporter
NDK23_RS07620	COG0842	Transport permease protein
NDK23_RS07625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NDK23_RS07640	COG0741	lytic transglycosylase activity
NDK23_RS07645	COG0723	plastoquinol--plastocyanin reductase activity
NDK23_RS07650	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NDK23_RS07655	COG2857	Cytochrome c1
NDK23_RS07660	COG0625	glutathione transferase activity
NDK23_RS07665	COG2969	positive regulation of protein catabolic process
NDK23_RS07700	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NDK23_RS07710	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NDK23_RS07725	COG1611	Belongs to the LOG family
NDK23_RS07770	COG0556	nucleotide-excision repair
NDK23_RS07810	COG3713	MltA-interacting MipA family protein
NDK23_RS07830	COG0811	peptide transport
NDK23_RS07845	COG1663	tetraacyldisaccharide 4'-kinase activity
NDK23_RS07850	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
NDK23_RS07855	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NDK23_RS07865	COG0322	excinuclease ABC activity
NDK23_RS07905	COG0577	efflux transmembrane transporter activity
NDK23_RS07905	COG1136	(ABC) transporter
NDK23_RS07965	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NDK23_RS07990	COG0583	DNA-binding transcription factor activity
NDK23_RS08010	COG1917	Cupin 2, conserved barrel domain protein
NDK23_RS08010	COG4977	sequence-specific DNA binding
NDK23_RS08015	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NDK23_RS08035	COG0348	domain, Protein
NDK23_RS08050	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NDK23_RS08065	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NDK23_RS08070	COG0069	glutamate synthase activity
NDK23_RS08095	COG1054	Belongs to the UPF0176 family
NDK23_RS08100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NDK23_RS08115	COG1253	flavin adenine dinucleotide binding
NDK23_RS08125	COG0306	phosphate transporter
NDK23_RS08135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NDK23_RS08150	COG0504	CTP synthase activity
NDK23_RS08155	COG2877	3-deoxy-8-phosphooctulonate synthase activity
NDK23_RS08170	COG0148	phosphopyruvate hydratase activity
NDK23_RS08175	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NDK23_RS08180	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NDK23_RS08185	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NDK23_RS08195	COG2840	Smr protein MutS2
NDK23_RS08200	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NDK23_RS08205	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NDK23_RS08230	COG1534	Rna-binding protein
NDK23_RS08235	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
NDK23_RS08240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NDK23_RS08255	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NDK23_RS08260	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NDK23_RS08265	COG1923	regulation of RNA biosynthetic process
NDK23_RS08270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NDK23_RS08275	COG1546	Belongs to the CinA family
NDK23_RS08280	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NDK23_RS08285	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NDK23_RS08290	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NDK23_RS08295	COG2137	regulation of response to DNA damage stimulus
NDK23_RS08300	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NDK23_RS08305	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
NDK23_RS08355	COG3540	Alkaline phosphatase
NDK23_RS08370	COG3258	Cytochrome c
NDK23_RS08385	COG2223	nitrite transmembrane transporter activity
NDK23_RS08400	COG1741	Belongs to the pirin family
NDK23_RS08405	COG0583	DNA-binding transcription factor activity
NDK23_RS08430	COG0351	phosphomethylpyrimidine kinase
NDK23_RS08430	COG0352	thiamine-phosphate diphosphorylase activity
NDK23_RS08445	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NDK23_RS08450	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NDK23_RS08460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NDK23_RS08470	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
NDK23_RS08475	COG0477	Major facilitator Superfamily
NDK23_RS08485	COG0617	tRNA 3'-terminal CCA addition
NDK23_RS08490	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NDK23_RS08495	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NDK23_RS08500	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NDK23_RS08510	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NDK23_RS08515	COG0166	Belongs to the GPI family
NDK23_RS08520	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
NDK23_RS08530	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NDK23_RS08535	COG0671	phosphoesterase, PA-phosphatase related
NDK23_RS08545	COG0800	Aldolase
NDK23_RS08550	COG0129	dihydroxy-acid dehydratase activity
NDK23_RS08560	COG0837	glucose binding
NDK23_RS08585	COG2009	succinate dehydrogenase
NDK23_RS08590	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
NDK23_RS08595	COG1053	succinate dehydrogenase
NDK23_RS08615	COG4591	ABC-type transport system involved in lipoprotein release permease component
NDK23_RS08630	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
NDK23_RS08640	COG0552	protein localization to endoplasmic reticulum
NDK23_RS08655	COG0742	ribosomal rna small subunit methyltransferase
NDK23_RS08660	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NDK23_RS08670	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
NDK23_RS08675	COG0405	Gamma-glutamyltransferase
NDK23_RS08680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NDK23_RS08700	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NDK23_RS08720	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NDK23_RS08730	COG0415	Belongs to the DNA photolyase family
NDK23_RS08735	COG2885	chlorophyll binding
NDK23_RS08740	COG0583	DNA-binding transcription factor activity
NDK23_RS08835	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NDK23_RS08845	COG2914	Belongs to the UPF0125 (RnfH) family
NDK23_RS08850	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NDK23_RS08855	COG0735	belongs to the Fur family
NDK23_RS08865	COG0583	DNA-binding transcription factor activity
NDK23_RS08870	COG0497	DNA recombination
NDK23_RS08875	COG1420	regulation of RNA biosynthetic process
NDK23_RS08880	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NDK23_RS08885	COG0443	Heat shock 70 kDa protein
NDK23_RS08890	COG0484	heat shock protein binding
NDK23_RS08895	COG2207	Transcriptional regulator
NDK23_RS08900	COG2223	nitrite transmembrane transporter activity
NDK23_RS08905	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
NDK23_RS08910	COG0287	Prephenate dehydrogenase
NDK23_RS08910	COG1605	Chorismate mutase
NDK23_RS08920	COG1132	(ABC) transporter
NDK23_RS08950	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NDK23_RS08955	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NDK23_RS08960	COG0343	queuine tRNA-ribosyltransferase activity
NDK23_RS08965	COG1862	Preprotein translocase
NDK23_RS08975	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NDK23_RS08980	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NDK23_RS08990	COG2081	HI0933 family
NDK23_RS08995	COG4681	YaeQ
NDK23_RS09015	COG0625	glutathione transferase activity
NDK23_RS09020	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NDK23_RS09025	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NDK23_RS09030	COG0513	Belongs to the DEAD box helicase family
NDK23_RS09040	COG0583	DNA-binding transcription factor activity
NDK23_RS09045	COG0488	(ABC) transporter
NDK23_RS09070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NDK23_RS09085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NDK23_RS09090	COG2957	Belongs to the agmatine deiminase family
NDK23_RS09100	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NDK23_RS09105	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NDK23_RS09115	COG0776	regulation of translation
NDK23_RS09125	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
NDK23_RS09130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NDK23_RS09140	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NDK23_RS09145	COG0183	Belongs to the thiolase family
NDK23_RS09150	COG1250	3-hydroxyacyl-CoA dehydrogenase
NDK23_RS09150	COG1024	Enoyl-CoA hydratase
NDK23_RS09160	COG0105	UTP biosynthetic process
NDK23_RS09165	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NDK23_RS09170	COG0457	Tetratricopeptide repeat
NDK23_RS09170	COG0859	PFAM glycosyl transferase family 9
NDK23_RS09175	COG1426	Protein conserved in bacteria
NDK23_RS09175	COG1426	Protein conserved in bacteria
NDK23_RS09185	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NDK23_RS09190	COG1160	GTP binding
NDK23_RS09210	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NDK23_RS09215	COG0475	glutathione-regulated potassium exporter activity
NDK23_RS09215	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NDK23_RS09230	COG0519	Catalyzes the synthesis of GMP from XMP
NDK23_RS09230	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NDK23_RS09250	COG0583	DNA-binding transcription factor activity
NDK23_RS09280	COG1028	Short-chain dehydrogenase reductase Sdr
NDK23_RS09305	COG0640	Transcriptional regulator
NDK23_RS09320	COG4716	Myosin-crossreactive antigen
NDK23_RS09350	COG4206	TonB-dependent receptor
NDK23_RS09355	COG0431	NADPH-dependent FMN reductase
NDK23_RS09365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NDK23_RS09370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NDK23_RS09375	COG1473	amidohydrolase
NDK23_RS09390	COG1126	abc transporter atp-binding protein
NDK23_RS09395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NDK23_RS09425	COG4943	cyclic-guanylate-specific phosphodiesterase activity
NDK23_RS09430	COG0583	DNA-binding transcription factor activity
NDK23_RS09435	COG0477	Major facilitator Superfamily
NDK23_RS09440	COG1028	Short-chain dehydrogenase reductase Sdr
NDK23_RS09450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NDK23_RS09470	COG1309	transcriptional regulator
NDK23_RS09485	COG0697	spore germination
NDK23_RS09490	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NDK23_RS09495	COG0167	dihydroorotate dehydrogenase activity
NDK23_RS09510	COG1028	Short-chain dehydrogenase reductase Sdr
NDK23_RS09515	COG1012	belongs to the aldehyde dehydrogenase family
NDK23_RS09650	COG0784	Response regulator, receiver
NDK23_RS09650	COG4191	Histidine kinase
NDK23_RS09655	COG2205	protein histidine kinase activity
NDK23_RS09655	COG3437	response regulator, receiver
NDK23_RS09655	COG3850	Histidine kinase
NDK23_RS09655	COG4999	Histidine kinase
NDK23_RS09660	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NDK23_RS09675	COG0640	Transcriptional regulator
NDK23_RS09715	COG0527	aspartate kinase activity
NDK23_RS09715	COG0460	homoserine dehydrogenase
NDK23_RS09720	COG0083	homoserine kinase activity
NDK23_RS09725	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NDK23_RS09730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NDK23_RS09735	COG0124	histidyl-tRNA synthetase
NDK23_RS09745	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NDK23_RS09750	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NDK23_RS09755	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NDK23_RS09760	COG0131	Imidazoleglycerol-phosphate dehydratase
NDK23_RS09760	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NDK23_RS09765	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NDK23_RS09770	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NDK23_RS09775	COG0107	imidazoleglycerol-phosphate synthase activity
NDK23_RS09780	COG0140	phosphoribosyl-ATP diphosphatase activity
NDK23_RS09780	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NDK23_RS09800	COG1446	asparaginase
NDK23_RS09805	COG3142	Participates in the control of copper homeostasis
NDK23_RS09815	COG2217	Heavy metal translocating P-type atpase
NDK23_RS09820	COG0789	Transcriptional regulator
NDK23_RS09835	COG3537	Alpha-1,2-mannosidase
NDK23_RS09840	COG1609	Transcriptional regulator
NDK23_RS09850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NDK23_RS09865	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
NDK23_RS09870	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
NDK23_RS09875	COG0235	Class ii aldolase
NDK23_RS09885	COG0531	amino acid
NDK23_RS09890	COG0531	amino acid
NDK23_RS09900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NDK23_RS09905	COG0277	FAD linked oxidase domain protein
NDK23_RS09920	COG2205	protein histidine kinase activity
NDK23_RS09925	COG0745	RESPONSE REGULATOR receiver
NDK23_RS09930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NDK23_RS09935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NDK23_RS09950	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NDK23_RS09995	COG2249	NAD(P)H dehydrogenase (quinone) activity
NDK23_RS10010	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NDK23_RS10015	COG0505	Belongs to the CarA family
NDK23_RS10020	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NDK23_RS10025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NDK23_RS10040	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NDK23_RS10045	COG4676	Protein conserved in bacteria
NDK23_RS10060	COG3279	Response regulator of the LytR AlgR family
NDK23_RS10075	COG1012	belongs to the aldehyde dehydrogenase family
NDK23_RS10095	COG0784	Response regulator, receiver
NDK23_RS10095	COG2198	Histidine kinase
NDK23_RS10095	COG2205	protein histidine kinase activity
NDK23_RS10100	COG1024	Enoyl-CoA hydratase
NDK23_RS10105	COG0318	PFAM AMP-dependent synthetase and ligase
NDK23_RS10110	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
NDK23_RS10115	COG1012	belongs to the aldehyde dehydrogenase family
NDK23_RS10120	COG1309	transcriptional regulator
NDK23_RS10125	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NDK23_RS10170	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
NDK23_RS10180	COG0840	transmembrane signaling receptor activity
NDK23_RS10185	COG0840	transmembrane signaling receptor activity
NDK23_RS10195	COG0835	chemotaxis
NDK23_RS10200	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
NDK23_RS10205	COG0840	transmembrane signaling receptor activity
NDK23_RS10215	COG0745	RESPONSE REGULATOR receiver
NDK23_RS10225	COG0835	chemotaxis
NDK23_RS10235	COG1360	Flagellar Motor Protein
NDK23_RS10240	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NDK23_RS10245	COG0784	Response regulator, receiver
NDK23_RS10245	COG2198	Histidine kinase
NDK23_RS10245	COG0643	Histidine kinase
NDK23_RS10250	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
NDK23_RS10275	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NDK23_RS10280	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NDK23_RS10300	COG1987	bacterial-type flagellum assembly
NDK23_RS10310	COG3190	flagellar
NDK23_RS10360	COG1677	Flagellar hook-basal body complex protein FliE
NDK23_RS10390	COG2197	response regulator
NDK23_RS10410	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
NDK23_RS10450	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
NDK23_RS10460	COG4787	bacterial-type flagellum-dependent cell motility
NDK23_RS10475	COG1558	bacterial-type flagellum-dependent cell motility
NDK23_RS10480	COG1815	bacterial-type flagellum-dependent cell motility
NDK23_RS10485	COG0835	chemotaxis
NDK23_RS10485	COG0784	Response regulator, receiver
NDK23_RS10505	COG5002	protein histidine kinase activity
NDK23_RS10540	COG2915	High frequency lysogenization protein hflD homolog
NDK23_RS10545	COG0482	sulfurtransferase activity
NDK23_RS10560	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NDK23_RS10570	COG0542	response to heat
NDK23_RS10600	COG0492	ferredoxin-NADP+ reductase activity
NDK23_RS10605	COG1674	ftsk spoiiie
NDK23_RS10620	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NDK23_RS10635	COG2819	hydrolase of the alpha beta superfamily
NDK23_RS10645	COG4558	Periplasmic binding protein
NDK23_RS10650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NDK23_RS10655	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
NDK23_RS10665	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NDK23_RS10715	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NDK23_RS10725	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
NDK23_RS10740	COG1595	DNA-templated transcription, initiation
NDK23_RS10760	COG0784	Response regulator, receiver
NDK23_RS10765	COG4251	negative regulation of phosphorylation
NDK23_RS10775	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
NDK23_RS10785	COG0454	-acetyltransferase
NDK23_RS10785	COG0456	acetyltransferase
NDK23_RS10925	COG0084	hydrolase, TatD family'
NDK23_RS10930	COG2801	Transposase and inactivated derivatives
NDK23_RS10990	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NDK23_RS11000	COG0542	response to heat
NDK23_RS11005	COG0071	Belongs to the small heat shock protein (HSP20) family
NDK23_RS11035	COG0789	Transcriptional regulator
NDK23_RS11040	COG2608	mercury ion transmembrane transporter activity
NDK23_RS11045	COG2608	mercury ion transmembrane transporter activity
NDK23_RS11055	COG0789	Transcriptional regulator
NDK23_RS11075	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NDK23_RS11080	COG4644	lycopene metabolic process
NDK23_RS11115	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
NDK23_RS11150	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NDK23_RS11165	COG0010	Belongs to the arginase family
NDK23_RS11220	COG2132	Multicopper oxidase
NDK23_RS11245	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NDK23_RS11300	COG4644	lycopene metabolic process
NDK23_RS11340	COG1902	pentaerythritol trinitrate reductase activity
NDK23_RS11355	COG1309	transcriptional regulator
NDK23_RS11455	COG3422	double-strand break repair
NDK23_RS11510	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NDK23_RS11515	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NDK23_RS11520	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NDK23_RS11525	COG2080	2 iron, 2 sulfur cluster binding
NDK23_RS11535	COG1764	response to oxidative stress
NDK23_RS11545	COG0583	DNA-binding transcription factor activity
NDK23_RS11565	COG1595	DNA-templated transcription, initiation
NDK23_RS11570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NDK23_RS11655	COG3685	Protein conserved in bacteria
NDK23_RS11680	COG3546	catalase activity
NDK23_RS11685	COG3685	Protein conserved in bacteria
NDK23_RS11710	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NDK23_RS11730	COG1063	alcohol dehydrogenase
NDK23_RS11760	COG1609	Transcriptional regulator
NDK23_RS11765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NDK23_RS11765	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NDK23_RS11770	COG1105	Belongs to the carbohydrate kinase PfkB family
NDK23_RS11775	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NDK23_RS11775	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NDK23_RS11790	COG1733	regulation of RNA biosynthetic process
NDK23_RS11795	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
NDK23_RS11810	COG4771	TonB-dependent receptor
NDK23_RS11815	COG0738	Major facilitator superfamily
NDK23_RS11820	COG1609	Transcriptional regulator
NDK23_RS11840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NDK23_RS11855	COG2828	Protein conserved in bacteria
NDK23_RS11860	COG0583	DNA-binding transcription factor activity
NDK23_RS11885	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NDK23_RS11890	COG0583	DNA-binding transcription factor activity
NDK23_RS11920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NDK23_RS11945	COG2205	protein histidine kinase activity
NDK23_RS11955	COG0318	PFAM AMP-dependent synthetase and ligase
NDK23_RS11970	COG2186	Transcriptional regulator
NDK23_RS11990	COG2271	Major facilitator Superfamily
NDK23_RS11995	COG1028	Short-chain dehydrogenase reductase Sdr
NDK23_RS12005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NDK23_RS12030	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NDK23_RS12050	COG0583	DNA-binding transcription factor activity
NDK23_RS12075	COG2204	response regulator
NDK23_RS12150	COG0708	Exodeoxyribonuclease III
NDK23_RS12155	COG0366	Alpha amylase catalytic
NDK23_RS12160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NDK23_RS12170	COG1028	Short-chain dehydrogenase reductase Sdr
NDK23_RS12180	COG0577	efflux transmembrane transporter activity
NDK23_RS12180	COG1136	(ABC) transporter
NDK23_RS12185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NDK23_RS12195	COG0745	RESPONSE REGULATOR receiver
NDK23_RS12200	COG2205	protein histidine kinase activity
NDK23_RS12210	COG3214	Protein conserved in bacteria
NDK23_RS12220	COG4774	siderophore transport
NDK23_RS12240	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NDK23_RS12245	COG1285	pathogenesis
NDK23_RS12250	COG4191	Histidine kinase
NDK23_RS12255	COG4566	intracellular signal transduction
NDK23_RS12315	COG0243	molybdopterin cofactor binding
NDK23_RS12340	COG0477	Major facilitator Superfamily
NDK23_RS12365	COG1136	(ABC) transporter
NDK23_RS12380	COG0583	DNA-binding transcription factor activity
NDK23_RS12385	COG0656	L-ascorbic acid biosynthetic process
NDK23_RS12405	COG0583	DNA-binding transcription factor activity
NDK23_RS12410	COG1028	Short-chain dehydrogenase reductase Sdr
NDK23_RS12435	COG0642	Histidine kinase
NDK23_RS12440	COG3537	Alpha-1,2-mannosidase
NDK23_RS12455	COG0477	Major facilitator Superfamily
NDK23_RS12475	COG2202	Pas domain
NDK23_RS12475	COG3920	Histidine kinase
NDK23_RS12520	COG1335	isochorismatase
NDK23_RS12525	COG1335	isochorismatase
NDK23_RS12555	COG0811	peptide transport
NDK23_RS12650	COG1595	DNA-templated transcription, initiation
NDK23_RS12695	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NDK23_RS12700	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NDK23_RS12710	COG0840	transmembrane signaling receptor activity
NDK23_RS12715	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NDK23_RS12720	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NDK23_RS12725	COG4149	molybdate abc transporter
NDK23_RS12730	COG0725	ABC transporter, periplasmic molybdate-binding protein
NDK23_RS12735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NDK23_RS12750	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NDK23_RS12755	COG2181	nitrate reductase activity
NDK23_RS12760	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
NDK23_RS12765	COG1140	nitrate reductase beta subunit
NDK23_RS12770	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
NDK23_RS12775	COG2223	nitrite transmembrane transporter activity
NDK23_RS12785	COG0746	molybdenum cofactor guanylyltransferase activity
NDK23_RS12790	COG0314	molybdopterin synthase activity
NDK23_RS12800	COG0303	'Molybdopterin
NDK23_RS12805	COG0315	cyclic pyranopterin monophosphate synthase activity
NDK23_RS12805	COG0521	Mo-molybdopterin cofactor biosynthetic process
NDK23_RS12810	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NDK23_RS12875	COG2207	Transcriptional regulator
NDK23_RS12915	COG2205	protein histidine kinase activity
NDK23_RS12925	COG2194	sulfuric ester hydrolase activity
NDK23_RS12945	COG2885	chlorophyll binding
NDK23_RS12960	COG1028	Short-chain dehydrogenase reductase Sdr
NDK23_RS12965	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
NDK23_RS12965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NDK23_RS12970	COG3433	isochorismatase activity
NDK23_RS12970	COG1535	isochorismatase
NDK23_RS12975	COG3433	isochorismatase activity
NDK23_RS12975	COG1535	isochorismatase
NDK23_RS12980	COG1021	2,3-dihydroxybenzoate-AMP ligase
NDK23_RS12985	COG1169	isochorismate synthase
NDK23_RS12995	COG2409	Drug exporters of the RND superfamily
NDK23_RS13000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NDK23_RS13070	COG1914	H( )-stimulated, divalent metal cation uptake system
NDK23_RS13085	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NDK23_RS13090	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NDK23_RS13095	COG0604	alcohol dehydrogenase
NDK23_RS13095	COG1028	Short-chain dehydrogenase reductase Sdr
NDK23_RS13095	COG3321	synthase
NDK23_RS13100	COG4206	TonB-dependent receptor
NDK23_RS13105	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NDK23_RS13140	COG0583	DNA-binding transcription factor activity
NDK23_RS13150	COG4772	TonB-dependent receptor
NDK23_RS13170	COG2226	methyltransferase
NDK23_RS13215	COG4964	Belongs to the GSP D family
NDK23_RS13270	COG2814	Major facilitator Superfamily
NDK23_RS13280	COG1228	amidohydrolase
NDK23_RS13290	COG1335	isochorismatase
NDK23_RS13305	COG3850	Histidine kinase
NDK23_RS13310	COG2197	response regulator
NDK23_RS13315	COG2814	Major facilitator Superfamily
NDK23_RS13325	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NDK23_RS13335	COG0583	DNA-binding transcription factor activity
NDK23_RS13350	COG3161	chorismate lyase activity
NDK23_RS13390	COG0277	FAD linked oxidase domain protein
NDK23_RS13395	COG1304	FMN binding
NDK23_RS13400	COG2186	Transcriptional regulator
NDK23_RS13410	COG1285	pathogenesis
NDK23_RS13435	COG2814	Major facilitator Superfamily
NDK23_RS13490	COG0587	DNA-directed DNA polymerase activity
NDK23_RS13505	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NDK23_RS13510	COG0519	Catalyzes the synthesis of GMP from XMP
NDK23_RS13510	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NDK23_RS13525	COG1595	DNA-templated transcription, initiation
NDK23_RS13535	COG1629	transport
NDK23_RS13535	COG4206	TonB-dependent receptor
NDK23_RS13565	COG0531	amino acid
NDK23_RS13580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NDK23_RS13590	COG0789	Transcriptional regulator
NDK23_RS13670	COG5002	protein histidine kinase activity
NDK23_RS13670	COG3447	MASE1 domain protein
NDK23_RS13670	COG5001	Diguanylate cyclase
NDK23_RS13675	COG2183	response to ionizing radiation
NDK23_RS13690	COG1983	PspC domain protein
NDK23_RS13700	COG3243	poly(R)-hydroxyalkanoic acid synthase
NDK23_RS13715	COG0534	Mate efflux family protein
NDK23_RS13735	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
NDK23_RS13745	COG0668	transmembrane transport
NDK23_RS13750	COG1902	pentaerythritol trinitrate reductase activity
NDK23_RS13760	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
NDK23_RS13770	COG1733	regulation of RNA biosynthetic process
NDK23_RS13775	COG2249	NAD(P)H dehydrogenase (quinone) activity
NDK23_RS13780	COG0456	acetyltransferase
NDK23_RS13850	COG3702	type iv secretory pathway
NDK23_RS13870	COG2948	multi-organism process
NDK23_RS13880	COG3736	Type IV secretory pathway, component VirB8
NDK23_RS13890	COG3505	Type IV secretory pathway VirD4
NDK23_RS13905	COG2814	Major facilitator Superfamily
NDK23_RS13910	COG0789	Transcriptional regulator
NDK23_RS13945	COG0784	Response regulator, receiver
NDK23_RS13945	COG4191	Histidine kinase
NDK23_RS13960	COG4774	siderophore transport
NDK23_RS13980	COG1733	regulation of RNA biosynthetic process
NDK23_RS13985	COG0604	alcohol dehydrogenase
NDK23_RS13995	COG0210	DNA helicase
NDK23_RS14005	COG3209	COG3209 Rhs family protein
NDK23_RS14040	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NDK23_RS14050	COG0666	response to abiotic stimulus
NDK23_RS14120	COG1192	Involved in chromosome partitioning
NDK23_RS14285	COG3300	MHYT domain
NDK23_RS14285	COG5001	Diguanylate cyclase
NDK23_RS14490	COG0583	DNA-binding transcription factor activity
NDK23_RS14495	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NDK23_RS14505	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NDK23_RS14520	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NDK23_RS14525	COG1605	Chorismate mutase
NDK23_RS14525	COG0077	Prephenate dehydratase
NDK23_RS14530	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NDK23_RS14575	COG1228	amidohydrolase
NDK23_RS14590	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NDK23_RS14640	COG2957	Belongs to the agmatine deiminase family
NDK23_RS14645	COG0583	DNA-binding transcription factor activity
NDK23_RS14710	COG4993	Dehydrogenase
NDK23_RS14720	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
NDK23_RS14730	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
NDK23_RS14740	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NDK23_RS14745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NDK23_RS14760	COG0359	binds to the 23S rRNA
NDK23_RS14765	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NDK23_RS14770	COG0360	Binds together with S18 to 16S ribosomal RNA
NDK23_RS14780	COG0316	Belongs to the HesB IscA family
NDK23_RS14785	COG0017	Asparaginyl-tRNA synthetase
NDK23_RS14805	COG0288	reversible hydration of carbon dioxide
NDK23_RS14815	COG3844	kynureninase activity
NDK23_RS14820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NDK23_RS14825	COG2925	Exonuclease
NDK23_RS14850	COG2902	Dehydrogenase
NDK23_RS14860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NDK23_RS14865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NDK23_RS14880	COG1960	acyl-CoA dehydrogenase activity
NDK23_RS14885	COG2226	methyltransferase
NDK23_RS14895	COG0646	methionine synthase
NDK23_RS14895	COG1410	methionine synthase
NDK23_RS14910	COG2900	Belongs to the SlyX family
NDK23_RS14925	COG0386	Belongs to the glutathione peroxidase family
NDK23_RS14935	COG1725	Transcriptional regulator
NDK23_RS14940	COG1131	(ABC) transporter
NDK23_RS14965	COG0114	fumarate hydratase activity
NDK23_RS14975	COG2850	peptidyl-arginine hydroxylation
NDK23_RS14985	COG0567	Dehydrogenase, E1 component
NDK23_RS15010	COG3540	Alkaline phosphatase
NDK23_RS15020	COG0305	Participates in initiation and elongation during chromosome replication
NDK23_RS15040	COG0625	glutathione transferase activity
NDK23_RS15060	COG0084	hydrolase, TatD family'
NDK23_RS15065	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NDK23_RS15100	COG0625	glutathione transferase activity
NDK23_RS15115	COG1595	DNA-templated transcription, initiation
NDK23_RS15120	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NDK23_RS15135	COG0386	Belongs to the glutathione peroxidase family
NDK23_RS15140	COG0339	signal peptide processing
NDK23_RS15150	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NDK23_RS15170	COG0705	Rhomboid family
NDK23_RS15175	COG3104	oligopeptide transport
NDK23_RS15185	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NDK23_RS15190	COG4290	ribonuclease
NDK23_RS15205	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
NDK23_RS15205	COG0316	Belongs to the HesB IscA family
NDK23_RS15210	COG2154	pterin-4-alpha-carbinolamine dehydratase
NDK23_RS15220	COG0428	transporter
NDK23_RS15230	COG1530	ribonuclease E activity
NDK23_RS15245	COG0395	ABC-type sugar transport system, permease component
NDK23_RS15275	COG0271	Belongs to the BolA IbaG family
NDK23_RS15280	COG2350	Protein conserved in bacteria
NDK23_RS15285	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NDK23_RS15290	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NDK23_RS15295	COG1187	pseudouridine synthase activity
NDK23_RS15305	COG2814	Major facilitator Superfamily
NDK23_RS15325	COG0436	Aminotransferase
NDK23_RS15330	COG4133	protoheme IX ABC transporter activity
NDK23_RS15350	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
NDK23_RS15365	COG3088	subunit of a heme lyase
NDK23_RS15365	COG4235	cytochrome complex assembly
NDK23_RS15375	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NDK23_RS15385	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NDK23_RS15390	COG4988	ABC transporter
NDK23_RS15400	COG1294	oxidase, subunit
NDK23_RS15430	COG0726	polysaccharide deacetylase
NDK23_RS15430	COG1649	PFAM Uncharacterised BCR, COG1649
NDK23_RS15435	COG1215	transferase activity, transferring glycosyl groups
NDK23_RS15445	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NDK23_RS15460	COG0165	Argininosuccinate lyase
NDK23_RS15465	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NDK23_RS15475	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NDK23_RS15480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NDK23_RS15485	COG0137	argininosuccinate synthase activity
NDK23_RS15490	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NDK23_RS15505	COG2166	iron-sulfur cluster assembly
NDK23_RS15525	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NDK23_RS15545	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NDK23_RS15550	COG0402	S-adenosylhomocysteine deaminase activity
NDK23_RS15555	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NDK23_RS15560	COG1509	lysine 2,3-aminomutase activity
NDK23_RS15565	COG5001	Diguanylate cyclase
NDK23_RS15565	COG3300	MHYT domain
NDK23_RS15585	COG0501	Belongs to the peptidase M48B family
NDK23_RS15595	COG1028	Short-chain dehydrogenase reductase Sdr
NDK23_RS15615	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NDK23_RS15620	COG0860	N-Acetylmuramoyl-L-alanine amidase
NDK23_RS15625	COG0802	atpase or kinase
NDK23_RS15630	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NDK23_RS15630	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NDK23_RS15635	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NDK23_RS15640	COG1570	exodeoxyribonuclease VII activity
NDK23_RS15650	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NDK23_RS15670	COG4771	TonB-dependent receptor
NDK23_RS15675	COG1309	transcriptional regulator
NDK23_RS15710	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NDK23_RS15710	COG2169	Transcriptional regulator
NDK23_RS15715	COG2130	NADP-dependent
NDK23_RS15745	COG1960	acyl-CoA dehydrogenase activity
NDK23_RS15755	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NDK23_RS15790	COG2076	Multidrug Resistance protein
NDK23_RS15795	COG5487	UPF0391 membrane protein
NDK23_RS15800	COG1280	lysine exporter protein (LysE YggA)
NDK23_RS15840	COG0776	regulation of translation
NDK23_RS15845	COG0072	phenylalanine-tRNA ligase activity
NDK23_RS15845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NDK23_RS15850	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NDK23_RS15855	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NDK23_RS15860	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NDK23_RS15865	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NDK23_RS15870	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NDK23_RS15910	COG1185	polyribonucleotide nucleotidyltransferase activity
NDK23_RS15915	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NDK23_RS15925	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NDK23_RS15930	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NDK23_RS15935	COG0195	Participates in both transcription termination and antitermination
NDK23_RS15940	COG0779	Required for maturation of 30S ribosomal subunits
NDK23_RS15955	COG1007	ATP synthesis coupled electron transport
NDK23_RS15970	COG0713	ATP synthesis coupled electron transport
NDK23_RS15980	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NDK23_RS15985	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NDK23_RS16000	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
NDK23_RS16005	COG0649	NAD binding
NDK23_RS16010	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NDK23_RS16015	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NDK23_RS16020	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NDK23_RS16035	COG0149	triose-phosphate isomerase activity
NDK23_RS16045	COG3083	sulfuric ester hydrolase activity
NDK23_RS16050	COG0438	transferase activity, transferring glycosyl groups
NDK23_RS16055	COG0726	polysaccharide deacetylase
NDK23_RS16060	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NDK23_RS16065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NDK23_RS16070	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NDK23_RS16075	COG0159	tryptophan synthase activity
NDK23_RS16085	COG0133	tryptophan synthase activity
NDK23_RS16105	COG0135	phosphoribosylanthranilate isomerase activity
NDK23_RS16110	COG0101	tRNA pseudouridine synthase activity
NDK23_RS16125	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NDK23_RS16135	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NDK23_RS16140	COG2890	protein-(glutamine-N5) methyltransferase activity
NDK23_RS16145	COG1999	signal sequence binding
NDK23_RS16150	COG0688	phosphatidylethanolamine metabolic process
NDK23_RS16165	COG0433	COG0433 Predicted ATPase
NDK23_RS16170	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NDK23_RS16180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NDK23_RS16185	COG0412	Dienelactone hydrolase
NDK23_RS16200	COG0717	Belongs to the dCTP deaminase family
NDK23_RS16205	COG0489	protein tyrosine kinase activity
NDK23_RS16210	COG4771	TonB-dependent receptor
NDK23_RS16215	COG4771	TonB-dependent receptor
NDK23_RS16225	COG3590	peptidase
NDK23_RS16260	COG0697	spore germination
NDK23_RS16270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NDK23_RS16275	COG2311	Membrane
NDK23_RS16280	COG1047	Peptidyl-prolyl cis-trans
NDK23_RS16285	COG0791	NLP P60 protein
NDK23_RS16290	COG0791	NLP P60 protein
NDK23_RS16295	COG1301	dicarboxylic acid transport
NDK23_RS16315	COG1722	exodeoxyribonuclease VII activity
NDK23_RS16320	COG0142	geranyltranstransferase activity
NDK23_RS16330	COG0312	modulator of DNA gyrase
NDK23_RS16335	COG3028	Belongs to the UPF0307 family
NDK23_RS16340	COG0312	modulator of DNA gyrase
NDK23_RS16360	COG2968	Membrane
NDK23_RS16370	COG4771	TonB-dependent receptor
NDK23_RS16385	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NDK23_RS16395	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NDK23_RS16410	COG0495	leucyl-tRNA aminoacylation
NDK23_RS16420	COG3118	belongs to the thioredoxin family
NDK23_RS16430	COG2203	Gaf domain
NDK23_RS16430	COG3706	GGDEF domain
NDK23_RS16430	COG4251	negative regulation of phosphorylation
NDK23_RS16430	COG5001	Diguanylate cyclase
NDK23_RS16460	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NDK23_RS16465	COG0346	lactoylglutathione lyase activity
NDK23_RS16475	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NDK23_RS16475	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NDK23_RS16485	COG2878	Part of a membrane complex involved in electron transport
NDK23_RS16490	COG0251	oxidation-reduction process
NDK23_RS16495	COG0392	lysyltransferase activity
NDK23_RS16495	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NDK23_RS16525	COG2824	Alkylphosphonate utilization operon protein PhnA
NDK23_RS16530	COG0443	Heat shock 70 kDa protein
NDK23_RS16570	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NDK23_RS16575	COG3122	Protein conserved in bacteria
NDK23_RS16580	COG1451	nucleotide metabolic process
NDK23_RS16590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NDK23_RS16610	COG0183	Belongs to the thiolase family
NDK23_RS16625	COG1960	acyl-CoA dehydrogenase activity
NDK23_RS16635	COG1793	dna ligase
NDK23_RS16640	COG1201	RNA secondary structure unwinding
NDK23_RS16655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NDK23_RS16660	COG1278	Cold shock
NDK23_RS16665	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NDK23_RS16670	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
NDK23_RS16675	COG1472	Belongs to the glycosyl hydrolase 3 family
NDK23_RS16680	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NDK23_RS16685	COG2954	triphosphatase activity
NDK23_RS16690	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NDK23_RS16695	COG0745	RESPONSE REGULATOR receiver
NDK23_RS16700	COG1381	Involved in DNA repair and RecF pathway recombination
NDK23_RS16705	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NDK23_RS16720	COG0681	Belongs to the peptidase S26 family
NDK23_RS16725	COG0481	GTPase activity
NDK23_RS16730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NDK23_RS16750	COG1741	Belongs to the pirin family
NDK23_RS16755	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NDK23_RS16765	COG1741	Belongs to the pirin family
NDK23_RS16770	COG1966	Carbon starvation protein
NDK23_RS16775	COG2879	small protein
NDK23_RS16790	COG2205	protein histidine kinase activity
NDK23_RS16830	COG2814	Major facilitator Superfamily
NDK23_RS16835	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NDK23_RS16835	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NDK23_RS16845	COG1113	amino acid transport
NDK23_RS16850	COG1917	Cupin 2, conserved barrel domain protein
NDK23_RS16850	COG2207	Transcriptional regulator
NDK23_RS16855	COG0753	catalase activity
NDK23_RS16885	COG1376	ErfK ybiS ycfS ynhG family protein
NDK23_RS16890	COG0739	heme binding
NDK23_RS16900	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NDK23_RS16910	COG0330	HflC and HflK could
NDK23_RS16915	COG0330	HflC and HflK could
NDK23_RS16920	COG0604	alcohol dehydrogenase
NDK23_RS16935	COG0678	peroxiredoxin activity
NDK23_RS16945	COG4953	penicillin-binding protein 1C
NDK23_RS16950	COG2373	Large extracellular alpha-helical protein
NDK23_RS16955	COG2079	MmgE PrpD family protein
NDK23_RS16960	COG2828	Protein conserved in bacteria
NDK23_RS16970	COG3609	addiction module antidote protein, CC2985 family
NDK23_RS16990	COG3829	transcription factor binding
NDK23_RS16995	COG2259	Doxx family
NDK23_RS17005	COG0259	pyridoxamine-phosphate oxidase activity
NDK23_RS17020	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NDK23_RS17040	COG0477	Major facilitator Superfamily
NDK23_RS17060	COG3038	cytochrome b561
NDK23_RS17075	COG1760	l-serine dehydratase
NDK23_RS17080	COG2267	carboxylic ester hydrolase activity
NDK23_RS17085	COG0460	homoserine dehydrogenase
NDK23_RS17085	COG0527	aspartate kinase activity
NDK23_RS17090	COG0626	cystathionine gamma-synthase activity
NDK23_RS17095	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NDK23_RS17100	COG0739	heme binding
NDK23_RS17105	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NDK23_RS17110	COG1272	protein, Hemolysin III
NDK23_RS17125	COG0463	Glycosyl transferase, family 2
NDK23_RS17130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NDK23_RS17135	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NDK23_RS17150	COG1309	transcriptional regulator
NDK23_RS17160	COG1960	acyl-CoA dehydrogenase activity
NDK23_RS17200	COG0583	DNA-binding transcription factor activity
NDK23_RS17210	COG0509	glycine decarboxylation via glycine cleavage system
NDK23_RS17215	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NDK23_RS17220	COG2801	Transposase and inactivated derivatives
NDK23_RS17220	COG3415	Transposase
NDK23_RS17230	COG0330	HflC and HflK could
NDK23_RS17240	COG1742	UPF0060 membrane protein
NDK23_RS17245	COG3956	TIGRFAM MazG family protein
NDK23_RS17255	COG0494	nUDIX hydrolase
NDK23_RS17265	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NDK23_RS17285	COG0840	transmembrane signaling receptor activity
NDK23_RS17290	COG0835	chemotaxis
NDK23_RS17305	COG0189	ligase activity
NDK23_RS17315	COG1214	PFAM Peptidase M22, glycoprotease
NDK23_RS17320	COG1199	ATP-dependent helicase activity
NDK23_RS17330	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NDK23_RS17335	COG1215	transferase activity, transferring glycosyl groups
NDK23_RS17350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NDK23_RS17360	COG1643	Atp-dependent helicase
NDK23_RS17365	COG0783	Belongs to the Dps family
NDK23_RS17375	COG0514	ATP-dependent DNA helicase (RecQ)
NDK23_RS17440	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NDK23_RS17445	COG0602	queuosine metabolic process
NDK23_RS17455	COG2885	chlorophyll binding
NDK23_RS17460	COG0823	Involved in the tonB-independent uptake of proteins
NDK23_RS17475	COG0811	peptide transport
NDK23_RS17480	COG0824	Thioesterase
NDK23_RS17485	COG2255	four-way junction helicase activity
NDK23_RS17495	COG0632	four-way junction helicase activity
NDK23_RS17500	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NDK23_RS17505	COG0217	transcriptional regulatory protein
NDK23_RS17525	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NDK23_RS17555	COG0488	(ABC) transporter
NDK23_RS17580	COG4651	solute:proton antiporter activity
NDK23_RS17580	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NDK23_RS17590	COG0745	RESPONSE REGULATOR receiver
NDK23_RS17595	COG2205	protein histidine kinase activity
NDK23_RS17605	COG0542	response to heat
NDK23_RS17625	COG0028	Belongs to the TPP enzyme family
NDK23_RS17650	COG3387	PFAM Glycoside hydrolase 15-related
NDK23_RS17655	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
NDK23_RS17660	COG3011	Protein conserved in bacteria
NDK23_RS17675	COG0564	pseudouridine synthase activity
NDK23_RS17680	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NDK23_RS17690	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NDK23_RS17690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NDK23_RS17700	COG0045	succinate-CoA ligase (ADP-forming) activity
NDK23_RS17735	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NDK23_RS17755	COG0745	RESPONSE REGULATOR receiver
NDK23_RS17770	COG0189	ligase activity
NDK23_RS17795	COG3240	lipase activity
NDK23_RS17795	COG4625	pathogenesis
NDK23_RS17805	COG2022	thiamine diphosphate biosynthetic process
NDK23_RS17810	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NDK23_RS17815	COG0471	metal ion transport
NDK23_RS17815	COG3273	potassium ion transport
NDK23_RS17835	COG1970	mechanosensitive ion channel activity
NDK23_RS17845	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NDK23_RS17850	COG1115	amino acid carrier protein
NDK23_RS17860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NDK23_RS17865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NDK23_RS17890	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
NDK23_RS17900	COG3588	fructose-bisphosphate aldolase
NDK23_RS17905	COG0469	pyruvate kinase activity
NDK23_RS17915	COG0126	phosphoglycerate kinase activity
NDK23_RS17935	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NDK23_RS17980	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NDK23_RS17985	COG1301	dicarboxylic acid transport
NDK23_RS18015	COG0714	Associated with various cellular activities
NDK23_RS18045	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
NDK23_RS18095	COG0254	rRNA binding
NDK23_RS18105	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NDK23_RS18115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NDK23_RS18120	COG1758	RNA polymerase activity
NDK23_RS18135	COG0437	4 iron, 4 sulfur cluster binding
NDK23_RS18140	COG2864	formate dehydrogenase
NDK23_RS18150	COG1921	L-seryl-tRNASec selenium transferase activity
NDK23_RS18155	COG3276	selenocysteine insertion sequence binding
NDK23_RS18165	COG0709	Synthesizes selenophosphate from selenide and ATP
NDK23_RS18180	COG1561	YicC-like family, N-terminal region
NDK23_RS18185	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NDK23_RS18190	COG0346	lactoylglutathione lyase activity
NDK23_RS18200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NDK23_RS18215	COG0006	proline dipeptidase activity
NDK23_RS18220	COG0006	proline dipeptidase activity
NDK23_RS18225	COG3079	Belongs to the UPF0149 family
NDK23_RS18245	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NDK23_RS18255	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
NDK23_RS18265	COG2912	Transglutaminase-like superfamily
NDK23_RS18270	COG1773	rubredoxin
NDK23_RS18280	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NDK23_RS18295	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NDK23_RS18300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NDK23_RS18310	COG1028	Short-chain dehydrogenase reductase Sdr
NDK23_RS18330	COG0671	phosphoesterase, PA-phosphatase related
NDK23_RS18340	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NDK23_RS18345	COG0563	adenylate kinase activity
NDK23_RS18365	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
NDK23_RS18375	COG0848	biopolymer transport protein
NDK23_RS18385	COG2832	Protein of unknown function (DUF454)
NDK23_RS18420	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NDK23_RS18445	COG0745	RESPONSE REGULATOR receiver
NDK23_RS18455	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NDK23_RS18460	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NDK23_RS18465	COG0405	Gamma-glutamyltransferase
NDK23_RS18470	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NDK23_RS18490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NDK23_RS18495	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NDK23_RS18510	COG0473	3-isopropylmalate dehydrogenase activity
NDK23_RS18525	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NDK23_RS18530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NDK23_RS18540	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
NDK23_RS18545	COG1538	Outer membrane efflux protein
NDK23_RS18550	COG0531	amino acid
NDK23_RS18555	COG1519	Transferase
NDK23_RS18560	COG1560	Kdo2-lipid A biosynthetic process
NDK23_RS18600	COG1301	dicarboxylic acid transport
NDK23_RS18610	COG4191	Histidine kinase
NDK23_RS18625	COG0642	Histidine kinase
NDK23_RS18640	COG2851	Citrate transporter
NDK23_RS18645	COG1028	Short-chain dehydrogenase reductase Sdr
NDK23_RS18665	COG1162	GTPase activity
NDK23_RS18670	COG0436	Aminotransferase
NDK23_RS18690	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NDK23_RS18710	COG1228	amidohydrolase
NDK23_RS18715	COG0804	urea catabolic process
NDK23_RS18725	COG1307	EDD domain protein, DegV family
NDK23_RS18765	COG5001	Diguanylate cyclase
NDK23_RS18765	COG4251	negative regulation of phosphorylation
NDK23_RS18765	COG3706	GGDEF domain
NDK23_RS18765	COG2203	Gaf domain
NDK23_RS18770	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
NDK23_RS18780	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
NDK23_RS18795	COG1902	pentaerythritol trinitrate reductase activity
NDK23_RS18820	COG0583	DNA-binding transcription factor activity
NDK23_RS18825	COG1064	alcohol dehydrogenase
NDK23_RS18845	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NDK23_RS18850	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NDK23_RS18860	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NDK23_RS18865	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NDK23_RS18880	COG1522	sequence-specific DNA binding
NDK23_RS18890	COG4773	Receptor
NDK23_RS18920	COG0617	tRNA 3'-terminal CCA addition
NDK23_RS18965	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NDK23_RS18970	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NDK23_RS18975	COG1609	Transcriptional regulator
NDK23_RS18985	COG0837	glucose binding
NDK23_RS18995	COG3525	Glycosyl hydrolase, family 20, catalytic domain
NDK23_RS19015	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NDK23_RS19040	COG4191	Histidine kinase
NDK23_RS19045	COG0784	Response regulator, receiver
NDK23_RS19050	COG4251	negative regulation of phosphorylation
NDK23_RS19055	COG2823	Periplasmic or secreted lipoprotein
NDK23_RS19060	COG0673	inositol 2-dehydrogenase activity
NDK23_RS19065	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NDK23_RS19085	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NDK23_RS19095	COG2921	Belongs to the UPF0250 family
NDK23_RS19105	COG1686	Belongs to the peptidase S11 family
NDK23_RS19110	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NDK23_RS19115	COG2951	lytic endotransglycosylase activity
NDK23_RS19120	COG0772	Belongs to the SEDS family
NDK23_RS19125	COG0772	Belongs to the SEDS family
NDK23_RS19140	COG1792	Involved in formation and maintenance of cell shape
NDK23_RS19145	COG1077	Cell shape determining protein MreB Mrl
NDK23_RS19150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NDK23_RS19165	COG0308	aminopeptidase N
NDK23_RS19170	COG2226	methyltransferase
NDK23_RS19200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NDK23_RS19215	COG0673	inositol 2-dehydrogenase activity
NDK23_RS19225	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
NDK23_RS19240	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NDK23_RS19250	COG2832	Protein of unknown function (DUF454)
NDK23_RS19260	COG0436	Aminotransferase
NDK23_RS19265	COG1505	serine-type exopeptidase activity
NDK23_RS19290	COG0697	spore germination
NDK23_RS19295	COG1666	GTP binding
NDK23_RS19310	COG0339	signal peptide processing
NDK23_RS19320	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NDK23_RS19340	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NDK23_RS19350	COG1136	(ABC) transporter
NDK23_RS19355	COG1136	(ABC) transporter
NDK23_RS19355	COG0577	efflux transmembrane transporter activity
NDK23_RS19360	COG0577	efflux transmembrane transporter activity
NDK23_RS19370	COG2204	response regulator
NDK23_RS19375	COG4191	Histidine kinase
NDK23_RS19385	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NDK23_RS19395	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NDK23_RS19400	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NDK23_RS19405	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NDK23_RS19410	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NDK23_RS19415	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NDK23_RS19420	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NDK23_RS19430	COG0356	it plays a direct role in the translocation of protons across the membrane
NDK23_RS19445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NDK23_RS19450	COG0508	dehydrogenase complex catalyzes the overall conversion of
NDK23_RS19470	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NDK23_RS19495	COG0181	hydroxymethylbilane synthase activity
NDK23_RS19505	COG0745	RESPONSE REGULATOR receiver
NDK23_RS19505	COG2972	Histidine kinase
NDK23_RS19520	COG4771	TonB-dependent receptor
NDK23_RS19555	COG0477	Major facilitator Superfamily
NDK23_RS19600	COG4206	TonB-dependent receptor
NDK23_RS19620	COG0625	glutathione transferase activity
NDK23_RS19635	COG2259	Doxx family
NDK23_RS19660	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NDK23_RS19720	COG0210	DNA helicase
NDK23_RS19760	COG2003	Belongs to the UPF0758 family
NDK23_RS19820	COG0582	viral genome integration into host DNA
NDK23_RS19830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NDK23_RS19835	COG1490	D-aminoacyl-tRNA deacylase activity
NDK23_RS19845	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NDK23_RS19880	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NDK23_RS19880	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NDK23_RS19885	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NDK23_RS19890	COG0242	peptide deformylase activity
NDK23_RS19900	COG0758	DNA mediated transformation
NDK23_RS19905	COG2922	Belongs to the Smg family
NDK23_RS19915	COG1714	RDD family
NDK23_RS19920	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NDK23_RS19920	COG1754	DNA topoisomerase type I activity
NDK23_RS19925	COG0009	L-threonylcarbamoyladenylate synthase
NDK23_RS19940	COG1028	Short-chain dehydrogenase reductase Sdr
NDK23_RS19950	COG0616	signal peptide processing
NDK23_RS19955	COG0534	Mate efflux family protein
NDK23_RS19970	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NDK23_RS19975	COG0625	glutathione transferase activity
NDK23_RS19985	COG1252	NADH dehydrogenase
NDK23_RS20005	COG2860	membrane
NDK23_RS20010	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NDK23_RS20030	COG1846	Transcriptional regulator
NDK23_RS20060	COG0459	protein refolding
NDK23_RS20065	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NDK23_RS20070	COG2356	endonuclease I
NDK23_RS20075	COG1324	tolerance protein
NDK23_RS20085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NDK23_RS20115	COG4585	Histidine kinase
NDK23_RS20135	COG0583	DNA-binding transcription factor activity
NDK23_RS20150	COG1785	Belongs to the alkaline phosphatase family
NDK23_RS20155	COG1686	Belongs to the peptidase S11 family
NDK23_RS20165	COG2249	NAD(P)H dehydrogenase (quinone) activity
NDK23_RS20175	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NDK23_RS20185	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NDK23_RS20190	COG0511	ligase activity, forming carbon-carbon bonds
NDK23_RS20195	COG0439	Biotin carboxylase
NDK23_RS20210	COG2264	protein methyltransferase activity
NDK23_RS20220	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
NDK23_RS20225	COG4589	Belongs to the CDS family
NDK23_RS20230	COG0204	Acyl-transferase
NDK23_RS20240	COG0671	phosphoesterase, PA-phosphatase related
NDK23_RS20240	COG2453	phosphatase
NDK23_RS20245	COG2267	carboxylic ester hydrolase activity
NDK23_RS20250	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NDK23_RS20255	COG0138	bifunctional purine biosynthesis protein purh
NDK23_RS20260	COG0151	Belongs to the GarS family
NDK23_RS20275	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NDK23_RS20280	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NDK23_RS20285	COG2201	protein-glutamate methylesterase activity
NDK23_RS20290	COG2177	Part of the ABC transporter FtsEX involved in
NDK23_RS20295	COG2884	Cell division ATP-binding protein ftsE
NDK23_RS20305	COG3118	belongs to the thioredoxin family
NDK23_RS20310	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NDK23_RS20315	COG3706	GGDEF domain
NDK23_RS20325	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
NDK23_RS20360	COG1652	LysM domain
NDK23_RS20365	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NDK23_RS20365	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NDK23_RS20370	COG1473	amidohydrolase
NDK23_RS20375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NDK23_RS20380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NDK23_RS20385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NDK23_RS20390	COG1289	transmembrane transporter activity
NDK23_RS20395	COG1028	Short-chain dehydrogenase reductase Sdr
NDK23_RS20400	COG2814	Major facilitator Superfamily
NDK23_RS20430	COG0316	Belongs to the HesB IscA family
NDK23_RS20455	COG5002	protein histidine kinase activity
NDK23_RS20455	COG0784	Response regulator, receiver
NDK23_RS20455	COG2205	protein histidine kinase activity
NDK23_RS20470	COG1051	belongs to the nudix hydrolase family
NDK23_RS20485	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NDK23_RS20490	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NDK23_RS20495	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
NDK23_RS20505	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
NDK23_RS20510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NDK23_RS20515	COG0730	response to heat
NDK23_RS20525	COG0134	indole-3-glycerol-phosphate synthase activity
NDK23_RS20530	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NDK23_RS20550	COG1597	lipid kinase activity
NDK23_RS20565	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
NDK23_RS20570	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NDK23_RS20580	COG2111	Na H antiporter
NDK23_RS20580	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NDK23_RS20585	COG1006	Multisubunit Na H antiporter MnhC subunit
NDK23_RS20590	COG0651	ATP synthesis coupled electron transport
NDK23_RS20595	COG1863	multisubunit Na H antiporter MnhE subunit
NDK23_RS20600	COG2212	antiporter activity
NDK23_RS20605	COG1320	monovalent cation:proton antiporter activity
NDK23_RS20610	COG0530	calcium, potassium:sodium antiporter activity
NDK23_RS20625	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
NDK23_RS20640	COG4804	nuclease activity
NDK23_RS20655	COG3104	oligopeptide transport
NDK23_RS20660	COG3483	tryptophan 2,3-dioxygenase activity
NDK23_RS20690	COG2378	regulation of single-species biofilm formation
NDK23_RS20705	COG2354	Protein conserved in bacteria
NDK23_RS20710	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NDK23_RS20715	COG1368	sulfuric ester hydrolase activity
NDK23_RS20720	COG3264	Mechanosensitive ion channel
NDK23_RS20720	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
NDK23_RS20725	COG2801	Transposase and inactivated derivatives
NDK23_RS20725	COG3415	Transposase
NDK23_RS20740	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NDK23_RS20775	COG1166	arginine decarboxylase activity
NDK23_RS20780	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NDK23_RS20795	COG2801	Transposase and inactivated derivatives
NDK23_RS20795	COG3415	Transposase
NDK23_RS20805	COG2960	long-chain fatty acid transporting porin activity
NDK23_RS20865	COG0606	chelatase, subunit chli
NDK23_RS20880	COG0561	phosphatase activity
NDK23_RS20885	COG3932	Exopolysaccharide synthesis, ExoD
NDK23_RS20915	COG1999	signal sequence binding
NDK23_RS20920	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NDK23_RS20925	COG1845	cytochrome c oxidase, subunit III
NDK23_RS20935	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NDK23_RS20940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NDK23_RS20955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NDK23_RS20960	COG1104	cysteine desulfurase activity
NDK23_RS21015	COG2031	fatty acid transporter
NDK23_RS21060	COG0673	inositol 2-dehydrogenase activity
NDK23_RS21070	COG1501	Belongs to the glycosyl hydrolase 31 family
NDK23_RS21075	COG2222	sugar isomerase
NDK23_RS21080	COG1940	carbohydrate kinase activity
NDK23_RS21090	COG1349	DNA-binding transcription factor activity
NDK23_RS21095	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NDK23_RS21100	COG2814	Major facilitator Superfamily
NDK23_RS21140	COG3210	domain, Protein
NDK23_RS21160	COG1040	competence protein
NDK23_RS21180	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NDK23_RS21185	COG0156	8-amino-7-oxononanoate synthase activity
NDK23_RS21190	COG2267	carboxylic ester hydrolase activity
NDK23_RS21210	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NDK23_RS21230	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NDK23_RS21235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NDK23_RS21240	COG2205	protein histidine kinase activity
NDK23_RS21245	COG0745	RESPONSE REGULATOR receiver
NDK23_RS21250	COG3541	Predicted nucleotidyltransferase
NDK23_RS21255	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NDK23_RS21280	COG0714	Associated with various cellular activities
NDK23_RS21295	COG0754	glutathionylspermidine amidase activity
NDK23_RS21305	COG0129	dihydroxy-acid dehydratase activity
NDK23_RS21310	COG1199	ATP-dependent helicase activity
NDK23_RS21320	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NDK23_RS21340	COG3781	membrane
NDK23_RS21370	COG0625	glutathione transferase activity
NDK23_RS21390	COG2207	Transcriptional regulator
NDK23_RS21405	COG4555	ABC transporter
NDK23_RS21435	COG0543	2 iron, 2 sulfur cluster binding
NDK23_RS21435	COG0633	Ferredoxin
NDK23_RS21440	COG1131	(ABC) transporter
NDK23_RS21445	COG0842	Transport permease protein
NDK23_RS21455	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NDK23_RS21465	COG0084	hydrolase, TatD family'
NDK23_RS21470	COG1643	Atp-dependent helicase
NDK23_RS21480	COG1187	pseudouridine synthase activity
NDK23_RS21495	COG0667	Aldo Keto reductase
NDK23_RS21510	COG1690	Belongs to the RtcB family
NDK23_RS21525	COG0840	transmembrane signaling receptor activity
NDK23_RS21530	COG0583	DNA-binding transcription factor activity
NDK23_RS21535	COG2814	Major facilitator Superfamily
NDK23_RS21540	COG0656	L-ascorbic acid biosynthetic process
NDK23_RS21565	COG2267	carboxylic ester hydrolase activity
NDK23_RS21595	COG0045	succinate-CoA ligase (ADP-forming) activity
NDK23_RS21595	COG1042	CoA-binding domain protein
NDK23_RS21595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NDK23_RS21600	COG2239	Acts as a magnesium transporter
NDK23_RS21610	COG0666	response to abiotic stimulus
NDK23_RS21610	COG3177	Filamentation induced by cAMP protein fic
NDK23_RS21615	COG3100	YcgL domain-containing protein
NDK23_RS21625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NDK23_RS21630	COG1028	Short-chain dehydrogenase reductase Sdr
NDK23_RS21650	COG0644	oxidoreductase
NDK23_RS21670	COG2986	histidine ammonia-lyase
NDK23_RS21680	COG0463	Glycosyl transferase, family 2
NDK23_RS21695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NDK23_RS21700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NDK23_RS21715	COG1294	oxidase, subunit
NDK23_RS21720	COG1271	oxidase subunit
NDK23_RS21775	COG0408	coproporphyrinogen oxidase activity
NDK23_RS21785	COG2323	membrane
NDK23_RS21800	COG0589	response to stress
NDK23_RS21825	COG0210	DNA helicase
NDK23_RS21835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NDK23_RS21840	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NDK23_RS21845	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NDK23_RS21850	COG1819	glycosyl
NDK23_RS21865	COG0251	oxidation-reduction process
NDK23_RS21900	COG0463	Glycosyl transferase, family 2
NDK23_RS21915	COG1475	DNA binding
NDK23_RS21920	COG1192	Involved in chromosome partitioning
NDK23_RS21925	COG0357	Ribosomal RNA small subunit methyltransferase G
NDK23_RS21930	COG2091	lysine biosynthetic process via aminoadipic acid
NDK23_RS21970	COG1971	Probably functions as a manganese efflux pump
NDK23_RS21975	COG0784	Response regulator, receiver
NDK23_RS21975	COG2205	protein histidine kinase activity
NDK23_RS21985	COG0443	Heat shock 70 kDa protein
NDK23_RS21995	COG2911	Protein conserved in bacteria
NDK23_RS22000	COG0729	surface antigen
NDK23_RS22010	COG0752	glycyl-tRNA synthetase alpha subunit
NDK23_RS22015	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NDK23_RS22020	COG0519	Catalyzes the synthesis of GMP from XMP
NDK23_RS22020	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NDK23_RS22030	COG0805	protein transport
NDK23_RS22040	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NDK23_RS22050	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NDK23_RS22055	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NDK23_RS22055	COG0596	Alpha beta hydrolase
NDK23_RS22060	COG0840	transmembrane signaling receptor activity
NDK23_RS22090	COG3135	benzoate transporter
NDK23_RS22105	COG2951	lytic endotransglycosylase activity
NDK23_RS22110	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
NDK23_RS22115	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NDK23_RS22120	COG3706	GGDEF domain
NDK23_RS22150	COG0302	gtp cyclohydrolase
NDK23_RS22165	COG1566	PFAM secretion protein HlyD family protein
NDK23_RS22175	COG1289	transmembrane transporter activity
NDK23_RS22190	COG1074	ATP-dependent DNA helicase activity
NDK23_RS22195	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
NDK23_RS22200	COG1127	ABC transporter
NDK23_RS22205	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NDK23_RS22210	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
NDK23_RS22225	COG2853	Lipoprotein
NDK23_RS22230	COG0386	Belongs to the glutathione peroxidase family
NDK23_RS22240	COG1322	Protein conserved in bacteria
NDK23_RS22250	COG0604	alcohol dehydrogenase
NDK23_RS22255	COG0583	DNA-binding transcription factor activity
NDK23_RS22275	COG0531	amino acid
NDK23_RS22285	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NDK23_RS22290	COG0861	Integral membrane protein TerC family
NDK23_RS22300	COG0584	glycerophosphoryl diester phosphodiesterase
NDK23_RS22315	COG0706	membrane insertase activity
NDK23_RS22320	COG0594	ribonuclease P activity
NDK23_RS22325	COG0230	Belongs to the bacterial ribosomal protein bL34 family